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bioinformatics, etc ; Biomphalaria glabrata; aquaculture; ganglia; genes; memory; nucleotide sequences; phylogeny; Show all 8 Subjects
Abstract:
... Previous studies have speculated that tidal rhythm of Onchidium reevesii was linked to its memory ability, which has not been well explained. Mapk1 and egr1 genes are closely related to memory formation in the MAPK signaling pathway that have been extensively studied in vertebrates. These two genes are involved in Long-term potentiation (LTP), which is generally regarded as one of the main molecul ...
Abdo Hassoun; Sandeep Jagtap; Guillermo Garcia-Garcia; Hana Trollman; Mirian Pateiro; José M. Lorenzo; Monica Trif; Alexandru Vasile Rusu; Rana Muhammad Aadil; Vida Šimat; Janna Cropotova; José S. Câmara
bioinformatics, etc ; artificial intelligence; automation; food analysis; food industry; food quality; Show all 6 Subjects
Abstract:
... Food quality has recently received considerable attention from governments, researchers, and consumers due to the increasing demand for healthier and more nutritious food products. Traditionally, food quality is determined using a range of destructive and time-consuming approaches with modest analytical performance, underscoring the urgent need to develop novel analytical techniques. The Fourth In ...
bioinformatics, etc ; acclimation; beta-fructofuranosidase; chromosomes; cold; cold stress; cultivars; genome; tea; water stress; Show all 10 Subjects
Abstract:
... Invertase inhibitor (InvInh) represses acid invertase (AI) activity though interacting with AI at post-translation level, which plays important roles in vegetative and reproductive processes and stress responses of plant. Our previous studies revealed that CsAI genes were involved in regulating cold response of tea plant, while the post-translation regulation mechanism of AI and the roles of InvIn ...
bioinformatics, etc ; allergenicity; electrophoresis; enzymatic hydrolysis; epitopes; experimental design; food chemistry; hydrophobicity; models; pea protein; peptides; peptidomics; subtilisin; vicilin; Show all 14 Subjects
Abstract:
... Enzymatic hydrolysis could reduce the allergenicity of pea protein. Box-Behnken model was used to extract vicilin with the lowest and highest allergenicity, and enzymatic hydrolysis, electrophoresis, spectroscopy, bioinformatics, and peptidomics of Nano-LC-MS/MS were utilized to explore the relationship between reduced allergenicity and structural changes. After enzymatic hydrolysis, the allergeni ...
bioinformatics, etc ; Chlorella; Comamonas; Pseudomonas stutzeri; acclimation; bioaugmentation; glyphosate; glyphosate resistance; microalgae; oxygen; photobioreactors; wastewater; wastewater treatment; water pollution; Europe; Show all 15 Subjects
Abstract:
... Glyphosate will be banned from Europe by the end of 2022, but its widespread use in the last decades and its persistence in the environment require the development of novel remediation processes. In this work, a bacterial consortium was designed de novo with the aim to remove glyphosate from polluted water, supported by the oxygen produced by a microalgal species. To this goal, bioinformatics tool ...
bioinformatics, etc ; brain neoplasms; data collection; databases; fibroblast growth factor receptor 3; gene expression; genes; glioblastoma; protein-protein interactions; therapeutics; Show all 10 Subjects
Abstract:
... Glioblastoma (GBM) is the most common malignant brain tumor among adults. Cancer stem cells (CSCs) are known to drive treatment resistance and recurrence. However, a few CSC markers have been identified as therapeutic targets for GBM. This study aimed to show highly coexpressed genes in GBM CSCs and TCGA GBM samples and to identify possible therapeutic targets for GBM. The gene expression profiles ...
bioinformatics, etc ; Ayurvedic medicine; Lagenaria siceraria; albino; alcohols; animals; atorvastatin; computer simulation; ferulic acid; food plants; hesperidin; high fat diet; hyperlipidemia; hypertension; insulin; lipids; mechanism of action; metabolites; obesity; p-coumaric acid; pharmacology; Show all 21 Subjects
Abstract:
... Lagenaria siceraria Stand. (Family: Cucurbitaceae), popularly known as bottle gourd, is traditionally used in Ayurvedic medicine as a food plant, especially in hypertension and obesity. Investigations were undertaken to assign novel lead combinations from this common food plant to multi-molecular modes of actions in the complex disease networks of obesity and hypertension. LC–MS/MS based metabolit ...
... Decabromodiphenyl ethane (DBDPE), a new brominated flame retardant, could negatively affect neurobehavior and pose health risks to humans. Humans are also exposed to widely used nanomaterials. This study investigated the combined toxic effects and action types of DBDPE and Zinc oxide nanoparticles (ZnO NPs) on human neuroblastoma SK-N-SH cells and the toxicity mechanisms. DBDPE inhibited the viabi ...
... The quantification of richness within a sample—either measured as the number of observed species or approximated by estimation—is a common first step in microbiome studies and is known to be highly dependent on sequencing depth, which itself is highly variable between samples. Rarefaction curves serve as a tool to investigate this dependency and it is often argued that after rarefying data—sub-sam ...
bioinformatics, etc ; condensates; ethylene; separation; Show all 4 Subjects
Abstract:
... Recent technological advances allow us to resolve molecular processes in living cells with high spatial and temporal resolution. Based on these technological advances, membraneless intracellular condensates formed by reversible functional aggregation and phase separation have been identified as important regulatory modules in diverse biological processes. Here, we present bioinformatic and cellula ...
... Supply Networks (SN) can be seriously affected by unplanned disruptions producing important consequences on system’s functioning. These alterations may have implications over dimensions of sustainability due to the re-adaptation of the network to cope with the disruptive event. In this sense, it is relevant to understand how sustainability can be measured while considering aspects like resilience ...
bioinformatics, etc ; biomedical research; drug interactions; Show all 3 Subjects
Abstract:
... Drug-drug interactions (DDIs) aim at describing the effect relations produced by a combination of two or more drugs. It is an important semantic processing task in the field of bioinformatics such as pharmacovigilance and clinical research. Recently, graph neural networks are applied on dependency graph to promote the performance of DDI extraction with better semantic representations. However, cur ...
Silvia Zemanová; Ľuboš Korytár; Jana Tomčová; Marián Prokeš; Monika Drážovská; Łukasz Myczko; Piotr Tryjanowski; Gréta Nusová; Alicja Matysiak; Anna Ondrejková
bioinformatics, etc ; ecology; molecular biology; prediction; Show all 4 Subjects
Abstract:
... Bats have been identified as reservoirs of zoonotic and potentially zoonotic pathogens. Significant progress was made in the field of molecular biology with regard to infectious diseases, especially those that infect more than one species. Molecular methods, sequencing and bioinformatics have recently become irreplaceable tools in emerging infectious diseases research and even outbreak prediction. ...
bioinformatics, etc ; Chlamydomonas reinhardtii; aminoacylation; chloroplasts; Show all 4 Subjects
Abstract:
... The chloroplast is a promising platform for biotechnological innovation due to its compact translation machinery. Nucleotide modifications within a minimal set of tRNAs modulate codon–anticodon interactions that are crucial for translation efficiency. However, a comprehensive assessment of these modifications does not presently exist in chloroplasts. Here, we synthesize all available information c ...
bioinformatics, etc ; biodiversity; molecular biology; statistics; Show all 4 Subjects
Abstract:
... Processing and visualising trends in the binary data (presence or absence of electropherogram peaks), obtained from fragment analysis methods in molecular biology, can be a time-consuming and often cumbersome process. Scoring and analysing binary data (from methods, such as AFLPs, ISSRs and RFLPs) entail complex workflows that require a high level of computational and bioinformatic skills. The app ...
bioinformatics, etc ; drug resistance; vaccine development; Show all 3 Subjects
Abstract:
... There are multiple tools for positive selection analysis, including vaccine design and detection of variants of circulating drug-resistant pathogens in population selection. However, applying these tools to analyze a large number of protein families or as part of a comprehensive phylogenomics pipeline could be challenging. Since many standard bioinformatics tools are only available as executables, ...
... Fine-grained navigation is becoming increasingly demanded in urban areas. However, current navigation software fails to provide accurate paths on grounds without roads (GWR) like residential communities, squares, parks, etc. In this work, a method for the construction of fine-grained navigation networks for urban environments is developed. Remote sensing images are used to estimate the traversabil ...
Juan Luis Pacheco‐Garcia; Dmitry Loginov; Bruno Rizzuti; Pavla Vankova; Jose L. Neira; Daniel Kavan; Noel Mesa‐Torres; Rita Guzzi; Petr Man; Angel L. Pey
bioinformatics, etc ; humans; mutation; phosphorylation; rats; Show all 5 Subjects
Abstract:
... The phosphomimetic mutation S82D in the cancer‐associated, FAD‐dependent human NADP(H):quinone oxidoreductase 1 (hNQO1) causes a decrease in flavin‐adenine dinucleotide‐binding affinity and intracellular stability. We test in this work whether the evolutionarily recent neutral mutation R80H in the vicinity of S82 may alter the strong functional effects of S82 phosphorylation through electrostatic ...
bioinformatics, etc ; Litsea; humans; sesquiterpenoids; spectroscopy; Show all 5 Subjects
Abstract:
... Five undescribed sesquiterpenoids (1–5), and nine known sesquiterpenoids (6–14) were obtained from the fruits of Litsea lancilimba Merr. by LC-MS/MS molecular networking strategies. Litsemene A (1) possessed a unique 8-member ring through unexpected cyclization of the methyl group on C-10 of guaiane. Their structures were elucidated by spectroscopic techniques including IR, UV, NMR, HR-ESI-MS, and ...
bioinformatics, etc ; ancestry; nucleotides; phylogeny; ribosomes; Show all 5 Subjects
Abstract:
... The theory of the RNA world, especially with the catalytic capability of RNA, provides a reasonable framework explaining the evolution of molecular genetics system before the scenario of the central dogma. However, it remains a challenge to deduce the origin mechanism of rRNAs. Here we reconstructed the phylogenetic relationships of archaea and bacteria with bootstrap values of most nodes, especia ...