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You searched for: Subject "biomarkers" Remove constraint Subject: "biomarkers"
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1. Adverse effects of triclosan on kidney in mice: Implication of lipid metabolism disorders

Author:
Wei Huang; Guodong Cao; Chengliang Deng; Yanyan Chen; Tao Wang; Da Chen; Zongwei Cai
Source:
Journal of environmental sciences (China) 2023 v.124 pp. 481-490
ISSN:
1001-0742
Subject:
biomarkers,   etc   ; beta oxidation; blood serum; corn oil; creatinine; cytokines; dimethyl sulfoxide; dose response; energy; fatty acid metabolism; fibrosis; hepatotoxicity; immune response; inflammation; kidneys; lipids; lipotoxicity; males; mass spectrometry; metabolites; mice; oxidative stress; renal function; thyroid function; triclosan; urea nitrogen; uric acid; China;     Show all 28 Subjects
Abstract:
... Triclosan (TCS) is a ubiquitous antimicrobial used in daily consumer products. Previous reports have shown that TCS could induce hepatotoxicity, endocrine disruption, disturbance on immune function and impaired thyroid function. Kidney is critical in the elimination of toxins, while the effects of TCS on kidney have not yet been well-characterized. The aim of the present study was to investigate t ...
DOI:
10.1016/j.jes.2021.11.032

2. Obtaining optimal cutoff values for tree classifiers using multiple biomarkers

Author:
Yuxin Zhu; Mei‐Cheng Wang
Source:
Biometrics 2022 v.78 no.1 pp. 128-140
ISSN:
0006-341X
Subject:
biomarkers,   etc   ; prediction; trees;     Show all 3 Subjects
Abstract:
... In biomedical practices, multiple biomarkers are often combined using a prespecified classification rule with tree structure for diagnostic decisions. The classification structure and cutoff point at each node of a tree are usually chosen on an ad hoc basis, depending on decision makers' experience. There is a lack of analytical approaches that lead to optimal prediction performance, and that guid ...
DOI:
10.1111/biom.13409

3. Circulating miRNA as potential biomarkers for diabetes mellitus type 2: should we focus on searching for sex differences?

Author:
Weronika Kraczkowska; Lucyna Stachowiak; Andrzej Pławski; Paweł Piotr Jagodziński
Source:
Journal of applied genetics 2022 v.63 no.2 pp. 293-303
ISSN:
1234-1983
Subject:
biomarkers,   etc   ; microRNA; nucleotides; pathogenesis;     Show all 4 Subjects
Abstract:
... microRNAs are non-coding molecules, approximately 22 nucleotides in length, that regulate various cellular processes. A growing body of evidence has suggested that their dysregulated expression is involved in the pathogenesis of diverse diseases, including diabetes mellitus type 2 (DM2). Early onset of this chronic and complex metabolic disorder is frequently undiagnosed, leading to the developmen ...
DOI:
10.1007/s13353-021-00678-5

4. Silicone Wristbands as Personal Passive Sampling Devices: Current Knowledge, Recommendations for Use, and Future Directions

Author:
Samantha M. Samon; Stephanie C. Hammel; Heather M. Stapleton; Kim A. Anderson
Source:
Environment international 2022 pp. 107339
ISSN:
0160-4120
Subject:
biomarkers,   etc   ; environment; exposome; silicone;     Show all 4 Subjects
Abstract:
... Personal chemical exposure assessment is necessary to determine the frequency and magnitude of individual chemical exposures, especially since chemicals present in everyday environments may lead to adverse health outcomes. In the last decade, silicone wristbands have emerged as a new chemical exposure assessment tool and have since been utilized for assessing personal exposure to a wide range of c ...
DOI:
10.1016/j.envint.2022.107339

5. Target identification and occupancy measurement of necrosis avid agent rhein using bioorthogonal chemistry-enabling probes

Author:
Cuihua Jiang; Jian Zhang; Shihe Hu; Meng Gao; Dongjian Zhang; Nan Yao; Qiaomei Jin
Source:
RSC advances 2022 v.12 no.26 pp. 16491-16495
ISSN:
2046-2069
Subject:
biomarkers,   etc   ; DNA; chemistry; necrosis;     Show all 4 Subjects
Abstract:
... Necrosis is an important biomarker, which only occurs in pathological situations. Tracking of necrosis avid agents is of crucial importance toward understanding their mechanisms. Herein, we developed a modular probe strategy based on bioorthogonal copper-free click chemistry. Structural modification of rhein with transcyclooctene (TCO) led to the identification of rhein-TCO2 as the most active pro ...
DOI:
10.1039/d2ra02844a

6. Construction and bioapplications of aptamer-based dual recognition strategy

Author:
Ya Wang; Xinlian Liu; Longjie Wu; Lihua Ding; Clement Yaw Effah; Yongjun Wu; Yamin Xiong; Leiliang He
Source:
Biosensors & bioelectronics 2022 v.195 pp. 113661
ISSN:
0956-5663
Subject:
biomarkers,   etc   ; biosensors; oligonucleotides; precision medicine;     Show all 4 Subjects
Abstract:
... Aptamer-based dual recognition strategy, using dual aptamers or the cooperation of aptamers with other recognition elements, can better utilize the advantages of each recognition molecule and increase the design flexibility to effectively overcome the limitations of a single molecule recognition strategy, thereby improving the sensitivity and selectivity and facilitating the regulation of biologic ...
DOI:
10.1016/j.bios.2021.113661

7. Peptide probes for proteases – innovations and applications for monitoring proteolytic activity

Author:
Maria Rodriguez-Rios; Alicia Megia-Fernandez; Daniel J. Norman; Mark Bradley
Source:
Chemical Society reviews 2022 v.51 no.6 pp. 2081-2120
ISSN:
1460-4744
Subject:
biomarkers,   etc   ; peptides; proteinases; proteolysis; therapeutics;     Show all 5 Subjects
Abstract:
... Proteases are excellent biomarkers for a variety of diseases, offer multiple opportunities for diagnostic applications and are valuable targets for therapy. From a chemistry-based perspective this review discusses and critiques the most recent advances in the field of substrate-based probes for the detection and analysis of proteolytic activity both in vitro and in vivo. ...
DOI:
10.1039/d1cs00798j

8. Biomarkers reveal Eocene marine incursions into the Qaidam Basin, north Tibetan Plateau

Author:
Jian Ma; Chaodong Wu; Benjamin T. Uveges; Weiming Ding; Roger E. Summons; Xingqian Cui
Source:
Organic geochemistry 2022 v.166 pp. 104380
ISSN:
0146-6380
Subject:
biomarkers,   etc   ; Eocene epoch; basins; geochemistry; China;     Show all 5 Subjects
Abstract:
... The easternmost extent of the large epicontinental Proto-Paratethys Sea is recorded in Eocene sediments of the Tarim Basin in western China. However, sporadic reports of marine-derived coccoliths in its eastern neighbor Qaidam Basin, which is conventionally considered to be an isolated lacustrine basin, cast doubt on this assumption. Here we present biomarker data on a core drilled in westernmost ...
DOI:
10.1016/j.orggeochem.2022.104380

9. Fluorescent probe strategy for live cell distinction

Author:
Xiao Liu; Young-Tae Chang
Source:
Chemical Society reviews 2022 v.51 no.5 pp. 1573-1591
ISSN:
1460-4744
Subject:
biomarkers,   etc   ; cold; fluorescence; fluorescent dyes; metabolism;     Show all 5 Subjects
Abstract:
... Live cell discrimination is the first and essential step to understand complex biosystems. Conventional cell discrimination involving various antibodies relies on selective surface biomarkers. Compared to antibodies, the fluorescent probe strategy allows the utilisation of intracellular biomarkers, providing broader options with unique chemical principles to achieve the live cell distinction. In g ...
DOI:
10.1039/d1cs00388g

10. Solid-State Nanochannel-Based Sensing Systems: Development, Challenges, and Opportunities

Author:
Yu Huang; Weiqi Zhang; Fan Xia; Lei Jiang
Source:
Langmuir 2022 v.38 no.8 pp. 2415-2422
ISSN:
1520-5827
Subject:
biomarkers,   etc   ; desalination; energy conversion; nanopores; seawater;     Show all 5 Subjects
Abstract:
... Solid-state nanochannel-based sensing systems with various structures and morphologies have realized precise measurements for various key biomarkers due to their tunable physical structures and morphologies, controllable chemical properties, and a nanoconfined space-induced target enriching effect. In the past several decades, series of solid-state nanochannel-based sensing systems mainly focused ...
DOI:
10.1021/acs.langmuir.1c03159

11. Stanniocalcin2 inhibits the epithelial-mesenchymal transition and invasion of trophoblasts via activation of autophagy under high-glucose conditions

Author:
Rujie Lai; Lulu Ji; Xiaoli Zhang; Yating Xu; Yu Zhong; Liying Chen; Hanyang Hu; Lin Wang
Source:
Molecular and cellular endocrinology 2022 v.547 pp. 111598
ISSN:
0303-7207
Subject:
biomarkers,   etc   ; autophagy; endocrinology; hyperglycemia; pregnancy; trophoblast;     Show all 6 Subjects
Abstract:
... Maternal pregnancy hyperglycemia is often accompanied by placental dysfunction. During placental development, epithelial-mesenchymal transition (EMT) contributes to the transformation of relatively noninvasive trophoblasts into highly invasive extravillous trophoblasts (EVTs). However, the specific role of EMT in placentas under hyperglycemia environments remains relatively unexplored. Stanniocalc ...
DOI:
10.1016/j.mce.2022.111598

12. Visualization of the Effect of Assay Size on the Error Profile of Tumor Mutational Burden Measurement

Author:
Nathanael G. Bailey
Source:
Genes 2022 v.13 no.3 pp. -
ISSN:
2073-4425
Subject:
biomarkers,   etc   ; Internet; genomics; neoplasms; therapeutics; uncertainty;     Show all 6 Subjects
Abstract:
... Tumor mutational burden (TMB) refers to the number of somatic mutations in a tumor per megabase and is a biomarker for response to immune checkpoint inhibitor therapy. Immune checkpoint inhibitors are currently approved for tumors with TMB greater than or equal to 10 mutations/megabase. Many laboratories are currently reporting TMB values based upon targeted resequencing panels with limited genomi ...
DOI:
10.3390/genes13030432

13. lncRNA-miRNA-mRNA Network in Primary Open Angle Glaucoma (POAG): In-Silico Trial

Author:
Amirhosein Maali; Seyed Ahmad Rasoulinejad
Source:
Russian journal of genetics 2022 v.58 no.6 pp. 730-735
ISSN:
1022-7954
Subject:
biomarkers,   etc   ; computer simulation; etiology; glaucoma; microRNA;     Show all 5 Subjects
Abstract:
... Primary open-angle glaucoma (POAG) is a type of glaucoma with a normal appearance of anterior chamber angle. The molecular etiology of POAG is unknown. This study aimed to investigate the possible role of non-coding RNAs in POAG. The down-regulation patterns were observed for 2495 probs, and 5548 probs were up-regulated. These 8043 up/down-regulated probs bind to 4984 different genes. In POAG pati ...
DOI:
10.1134/S1022795422060047

14. A Nutrition and Inflammation-Related Nomogram to Predict Overall Survival in Surgically Resected Esophageal Squamous Cell Carcinoma (ESCC) Patients

Author:
Juan Li; Xinyu Mei; Di Sun; Mingfa Guo; Mingran Xie; Xia Chen
Source:
Nutrition and cancer 2022 v.74 no.5 pp. 1625-1635
ISSN:
1532-7914
Subject:
biomarkers,   etc   ; models; nomogram; prognosis; squamous cell carcinoma;     Show all 5 Subjects
Abstract:
... Pretreatment inflammation-based biomarkers and the prognostic nutrition index (PNI) have been used to evaluate prognosis in cancer patients. However, few studies have focused on the prognostic value of post-treatment inflammation-based biomarkers and PNI in ESCC patients. We aimed to investigate the values of pre/post-treatment inflammatory parameters and PNI for establishing a nomogram to predict ...
DOI:
10.1080/01635581.2021.1957131

15. Analysis of single extracellular vesicles for biomedical applications with especial emphasis on cancer investigations

Author:
Ting Wang; Yanlong Xing; Ziyi Cheng; Fabiao Yu
Source:
Trends in analytical chemistry 2022 v.152 pp. 116604
ISSN:
0165-9936
Subject:
biomarkers,   etc   ; analytical chemistry; cell communication; lipids; prognosis;     Show all 5 Subjects
Abstract:
... Extracellular vesicles (EVs) are lipid membrane enclosed nano-sized vesicles that are secreted by all known organisms. These vesicles are increasingly recognized as important circulating biomarkers for the diagnosis and prognosis of different diseases including various types of cancer, owing to their essential role in intercellular communication. EVs preserve heterogeneity in both physical propert ...
DOI:
10.1016/j.trac.2022.116604

16. Disruption by stealth - Interference of endocrine disrupting chemicals on hormonal crosstalk with thyroid axis function in humans and other animals

Author:
Anita A. Thambirajah; Michael G. Wade; Jonathan Verreault; Nicolas Buisine; Verônica A. Alves; Valerie S. Langlois; Caren C. Helbing
Source:
Environmental research 2022 v.203 pp. 111906
ISSN:
0013-9351
Subject:
biomarkers,   etc   ; energy metabolism; homeostasis; pollution; reproduction; research;     Show all 6 Subjects
Abstract:
... Thyroid hormones (THs) are important regulators of growth, development, and homeostasis of all vertebrates. There are many environmental contaminants that are known to disrupt TH action, yet their mechanisms are only partially understood. While the effects of Endocrine Disrupting Chemicals (EDCs) are mostly studied as “hormone system silos”, the present critical review highlights the complexity of ...
DOI:
10.1016/j.envres.2021.111906

17. Endocytosis and intracellular RNAs imaging of nanomaterials-based fluorescence probes

Author:
Xinlian Liu; Ya Wang; Clement Yaw Effah; Longjie Wu; Fei Yu; Jinlan Wei; Guojiang Mao; Yamin Xiong; Leiliang He
Source:
Talanta 2022 v.243 pp. 123377
ISSN:
0039-9140
Subject:
biomarkers,   etc   ; RNA; deoxyribonucleases; endocytosis; fluorescence; therapeutics; transfection;     Show all 7 Subjects
Abstract:
... Recently, using nanomaterials to enhance the endocytosis capability and sensitivity of probes for RNA imaging in living cells has gotten the attention of many researchers. Nanomaterials, as a reliable alternative to transfection reagents, could prevent nucleic acid probes from being degraded by DNase, and bring them into sub-cellular locations for efficient internalization. Therefore, nanomaterial ...
DOI:
10.1016/j.talanta.2022.123377

18. MRI biomarkers for Alzheimer's disease: the impact of functional connectivity in the default mode network and structural connectivity between lobes on diagnostic accuracy

Author:
R. Mohtasib; J. Alghamdi; A. Jobeir; A. Masawi; N. Pedrosa de Barros; T. Billiet; H. Struyfs; T.V. Phan; W. Van Hecke; A. Ribbens
Source:
Heliyon 2022 v.8 no.2 pp. e08901
ISSN:
2405-8440
Subject:
biomarkers,   etc   ; Alzheimer disease; atrophy; decline; diffusivity; hippocampus;     Show all 6 Subjects
Abstract:
... At present, clinical use of MRI in Alzheimer's disease (AD) is mostly focused on the assessment of brain atrophy, namely in the hippocampal region. Despite this, multiple biomarkers reflecting structural and functional brain connectivity changes have shown promising results in the assessment of AD. To help identify the most relevant ones that may stand a chance of being used in clinical practice, ...
DOI:
10.1016/j.heliyon.2022.e08901

19. Quantum dots for electrochemical cytosensing

Author:
Rong Wu; Zhe Feng; Jingjing Zhang; Liping Jiang; Jun-Jie Zhu
Source:
Trends in analytical chemistry 2022 v.148 pp. 116531
ISSN:
0165-9936
Subject:
biomarkers,   etc   ; analytical chemistry; electrochemiluminescence; electrochemistry; metabolism; semiconductors;     Show all 6 Subjects
Abstract:
... Quantum dots (QDs), with confined size on the nanoscale (1–10 nm), are usually made of II−VI B group or III−V A group elements or their alloyed semiconductor materials. QDs are endowed with prominent electrochemical and photophysical properties, which makes QD-based assays powerful probes for electrochemical bioanalysis. Both excellent signal enhancement and functionalization have been explored an ...
DOI:
10.1016/j.trac.2022.116531

20. RNA polyadenylation patterns in the human transcriptome

Author:
Si-Mei Xu; Ashton Curry-Hyde; Vladimir Sytnyk; Michael Janitz
Source:
Gene 2022 v.816 pp. 146133
ISSN:
0378-1119
Subject:
biomarkers,   etc   ; adenine; gene expression; genes; humans; transcriptome;     Show all 6 Subjects
Abstract:
... The eukaryotic transcriptome undergoes various post-transcriptional modifications which assists gene expression. Polyadenylation is a molecular process occurring at the 3′-end of the RNA molecule which involves the poly(A) polymerase attaching adenine monophosphate molecules in a chain-like fashion to assemble a poly(A) tail. Multiple RNA isoforms are produced with differing 3′-UTR and exonic comp ...
DOI:
10.1016/j.gene.2021.146133