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1. Occurrence of symmetrical diacylguanidines triophamine and limaciamine in three polyceridae species from Canary Islands: are they chemical markers of these nudibranchs?

Author:
Carbone, Marianna; Herrero-Barrencua, Aketza; Ciavatta, M. Letizia; Castro, J. Juan; Cervera, J. Lucas; Gavagnin, Margherita
Source:
Biochemical systematics and ecology 2019 v.83 pp. 62-65
ISSN:
0305-1978
Subject:
biomarkers,   etc   ; Nudibranchia; taxonomy; Canary Islands;     Show all 4 Subjects
Abstract:
... Two symmetrical diacylguanidines, triophamine (1) and limaciamine (2), have been found to occur in three Polyceridae nudibranchs from Canary Islands. These compounds were previously reported from taxonomically related species collected from distinct geographical areas. Due to the peculiar occurrence of 1 and 2 in Polyceridae nudibranchs and, in particular, exclusively in members of Polycerinae and ...
DOI:
10.1016/j.bse.2019.01.005

2. Electrochemical analysis of 8-hydroxy-2′-deoxyguanosine with enhanced sensitivity based on exonuclease-mediated functional nucleic acid

Author:
Zheng, Ji; Gao, Tao; Shi, Hai; Huang, Yue; Xiang, Yang; Li, Genxi
Source:
Talanta 2019 v.199 pp. 324-328
ISSN:
0039-9140
Subject:
biomarkers,   etc   ; electrochemistry; enzymes; nucleic acids; urine;     Show all 5 Subjects
Abstract:
... In this work, an electrochemical method for sensitive analysis of 8-hydroxy-2′-deoxyguanosine, a key biomarker that is widely used to study oxidative injury-related diseases, is proposed based on exonuclease-mediated functional nucleic acid. In the design, exonuclease can not only distinguish the existence of target, but also suppress the background noise, thus the sensitivity can be enhanced. Mor ...
DOI:
10.1016/j.talanta.2019.02.080

3. MiRNA as biomarker for uveitis - A systematic review of the literature

Author:
Pockar, Sasa; Globocnik Petrovic, Mojca; Peterlin, Borut; Vidovic Valentincic, Natasa
Source:
Gene 2019 v.696 pp. 162-175
ISSN:
0378-1119
Subject:
biomarkers,   etc   ; databases; humans; inflammation; microRNA; systematic review;     Show all 6 Subjects
Abstract:
... A systematic review of miRNA profiling studies in uveitis.Literature search strategy - Pubmed central central database, using miRNA/microRNA and intraocular inflammation/uveitis as keywords.We found twenty publications regarding the experimental and clinical use of miRNA in uveitis, published between 2011 and 2018.The publications regarding the role of miRNA in uveitis are very scarce, but provide ...
DOI:
10.1016/j.gene.2019.02.004

4. Amplified visual detection of microRNA-378 through a T4 DNA ligase-mediated circular template specific to target and target-triggering rolling circle amplification

Author:
Liu, Zhanmin; Wang, Yanming; Li, Liping; Li, Junhai; Yuan, Yuanyuan
Source:
Analytical methods 2019 v.11 no.15 pp. 2082-2088
ISSN:
1759-9679
Subject:
biomarkers,   etc   ; DNA; blood serum; colorimetry; stomach neoplasms;     Show all 5 Subjects
Abstract:
... MicroRNA-378 (miRNA-378) is widely regarded as a novel noninvasive serum biomarker for early detection of gastric cancer. In the current study, a T4 DNA ligase-mediated circular template specific to target and a target-triggering rolling circle amplification (RCA) strategy was proposed for gastric cancer biomarker miRNA-378 visual detection. After multiple signal amplification through RCA and DNAz ...
DOI:
10.1039/c8ay02798f

5. Multiplexing techniques for measurement of the immunomodulatory effects of particulate materials: Precautions when testing micro- and nano-particles

Author:
Elsabahy, Mahmoud; Wooley, Karen L.; Hendricksen, Amy; Oh, Kenneth
Source:
Methods 2019 v.158 pp. 81-85
ISSN:
1046-2023
Subject:
biomarkers,   etc   ; adsorption; biocompatible materials; immunomodulators; microparticles; nanoparticles;     Show all 6 Subjects
Abstract:
... Particulate materials at nano- and micro-scales have widespread pharmaceutical and medical applications. Understanding the interactions of these materials with biological systems is crucial for the design of clinically-viable biomaterials of high safety profiles. Immunomodulatory effects of particulate materials can be studied via multiplexing techniques that are capable of measuring up to 500 bio ...
DOI:
10.1016/j.ymeth.2019.01.006

6. Assays for alkaline phosphatase activity: Progress and prospects

Author:
Tang, Zhenwei; Chen, Haotian; He, Hailun; Ma, Changbei
Source:
Trends in analytical chemistry 2019 v.113 pp. 32-43
ISSN:
0165-9936
Subject:
biomarkers,   etc   ; alkaline phosphatase; enzyme activity; immunity; industry;     Show all 5 Subjects
Abstract:
... Alkaline phosphatase (ALP) has become a representative enzyme of modern life industries. As a critical biomarker of numerous diseases and a major tool enzyme of experiments, classic methods for ALP assays fail to meet the emerging demand of sensitivity, precision, interference immunity and wide targeted types of sample. Therefore, numerous studies have been made to develop ALP detection strategies ...
DOI:
10.1016/j.trac.2019.01.019

7. Protein measurements in venous plasma, earlobe capillary plasma and in plasma stored on filter paper

Author:
Siart, Benjamin; de Oliveira, Felipe Marques Souza; Shen, Qiujin; Björkesten, Johan; Pekar, Thomas; Steinborn, Ralf; Nimmerichter, Alfred; Kamali-Moghaddam, Masood; Wallner, Bernard
Source:
Analytical biochemistry 2019 v.566 pp. 146-150
ISSN:
0003-2697
Subject:
biomarkers,   etc   ; blood; chemical species; males; proteins;     Show all 5 Subjects
Abstract:
... In this study, levels of inflammatory protein biomarkers in venous plasma, plasma derived from capillary blood from the earlobe, and capillary plasma stored as dried plasma spots (DPS) were compared. Samples from 12 male individuals were assessed with a panel of 92 inflammation-related proteins using multiplex proximity extension assay. Correlations between sample types varied greatly between anal ...
DOI:
10.1016/j.ab.2018.11.016

8. Correction to: The P/N (Positive-to-Negative Links) Ratio in Complex Networks—A Promising In Silico Biomarker for Detecting Changes Occurring in the Human Microbiome

Author:
Ma, Zhanshan(Sam)
Source:
Microbial ecology 2018 v.75 no.4 pp. 1074
ISSN:
0095-3628
Subject:
biomarkers,   etc   ; humans; microbiome;     Show all 3 Subjects
Abstract:
... The original version of this article unfortunately contained a missing image. The flowchart was not captured in PDF version. The original article was corrected. ...
DOI:
10.1007/s00248-017-1107-7

9. Simple and rapid extracellular vesicles quantification via membrane biotinylation strategy coupled with fluorescent nanospheres-based lateral flow assay

Author:
Dong, Di; Zhu, Lian; Hu, Jiao; Pang, Dai-Wen; Zhang, Zhi-Ling
Source:
Talanta 2019 v.200 pp. 408-414
ISSN:
0039-9140
Subject:
biomarkers,   etc   ; biotin; biotinylation; fluorescence; hydrophobic bonding; nanospheres; phosphatidylethanolamines; streptavidin;     Show all 8 Subjects
Abstract:
... Extracellular vesicles (EVs) are cell-excreted membrane particles existing in a variety of biological fluids. As potential noninvasive biomarkers, EVs have received wide attention in recent years. However, usual EVs assays are complex, time-consuming and costly, thus limiting their clinical utility. Simple and rapid EVs quantification within biological fluids remains challenging. Here, we develope ...
DOI:
10.1016/j.talanta.2019.03.069

10. Dynamical systems approaches to personalized medicine

Author:
Davis, Jacob D; Kumbale, Carla M; Zhang, Qiang; Voit, Eberhard O
Source:
Current opinion in biotechnology 2019 v.58 pp. 168-174
ISSN:
0958-1669
Subject:
biomarkers,   etc   ; computational methodology; humans; precision medicine; risk factors;     Show all 5 Subjects
Abstract:
... The complexity of the human body is a major roadblock to diagnosis and treatment of disease. Individuals may be diagnosed with the same disease but exhibit different biomarker profiles or physiological changes and, importantly, they may respond differently to the same risk factors and the same treatment. There is no doubt that computational methods of data analysis and interpretation must be devel ...
DOI:
10.1016/j.copbio.2019.03.005

11. Differentiation of weathered chemically dispersed oil from weathered crude oil

Author:
Song, Xing; Lye, Leonard M.; Chen, Bing; Zhang, Baiyu
Source:
Environmental monitoring and assessment 2019 v.191 no.5 pp. 270
ISSN:
0167-6369
Subject:
biomarkers,   etc   ; dispersants; oils; petroleum; principal component analysis; weathering;     Show all 6 Subjects
Abstract:
... Oil fingerprinting is a crucial technology to trace the sources and behaviors of spilled oil. The use of dispersants enhances the stay of dispersed oil in a water column and changes the important properties of spilled oil. In case of fingerprinting of dispersed oil driven by dispersants, the fate and behaviors of biomarkers may be affected by the application of dispersants. Limited studies have in ...
DOI:
10.1007/s10661-019-7392-5

12. Molecularly imprinted polymers for capturing and sensing proteins: Current progress and future implications

Author:
Ansari, Saeedeh; Masoum, Saeed
Source:
Trends in analytical chemistry 2019 v.114 pp. 29-47
ISSN:
0165-9936
Subject:
biomarkers,   etc   ; biomimetics; molecular imprinting; nanoparticles; polymers; receptors; sorbents;     Show all 7 Subjects
Abstract:
... Molecular recognition plays an important role in the numerous living systems. Molecularly imprinted polymers (MIPs) are tailor-made recognition particles that can mimic biological receptors and capable of sensitively and selectively recognize specific target molecules. In recent years, application of nanoparticles as sorbent has gained the significant attention in bioanalysis field. Molecular impr ...
DOI:
10.1016/j.trac.2019.02.008

13. Nanoarchitecture Frameworks for Electrochemical miRNA Detection

Author:
Masud, Mostafa Kamal; Umer, Muhammad; Hossain, Md. Shahriar A.; Yamauchi, Yusuke; Nguyen, Nam-Trung; Shiddiky, Muhammad J.A.
Source:
Trends in biochemical sciences 2019 v.44 no.5 pp. 433-452
ISSN:
0968-0004
Subject:
biomarkers,   etc   ; electrochemistry; high-throughput nucleotide sequencing; humans; microRNA; nanomaterials; transcriptome;     Show all 7 Subjects
Abstract:
... With revolutionary advances in next-generation sequencing, the human transcriptome has been comprehensively interrogated. These discoveries have highlighted the emerging functional and regulatory roles of a large fraction of RNAs suggesting the potential they might hold as stable and minimally invasive disease biomarkers. Although a plethora of molecular-biology- and biosensor-based RNA-detection ...
DOI:
10.1016/j.tibs.2018.11.012

14. A three plasma microRNA signature for papillary thyroid carcinoma diagnosis in Chinese patients

Author:
Wang, Zhiyan; Lv, Jinru; Zou, Xuan; Huang, Zebo; Zhang, Huo; Liu, Qingxie; Jiang, Lin; Zhou, Xin; Zhu, Wei
Source:
Gene 2019 v.693 pp. 37-45
ISSN:
0378-1119
Subject:
biomarkers,   etc   ; carcinoma; disease diagnosis; exosomes; goiter; microRNA; patients; screening; tissues;     Show all 9 Subjects
Abstract:
... Whether plasma miRNAs could be used as novel non-invasive biomarkers in diagnosing papillary thyroid carcinoma (PTC) remains unknown. In this study, we designed a four-phase study to identify differentially expressed plasma miRNAs in Chinese PTC patients. Exiqon panel was initially utilized to conduct plasma miRNA profile (3 PTC pools VS. 1 healthy control (HC) pool; each 10 samples were pooled as ...
DOI:
10.1016/j.gene.2019.01.016

15. Alkaline phosphatase-based electrochemical sensors for health applications

Author:
Nsabimana, Anaclet; Lan, Yixiang; Du, Fangxin; Wang, Chao; Zhang, Wei; Xu, Guobao
Source:
Analytical methods 2019 v.11 no.15 pp. 1996-2006
ISSN:
1759-9679
Subject:
biomarkers,   etc   ; alkaline phosphatase; analytical methods; bioassays; biosensors; monitoring; neoplasms;     Show all 7 Subjects
Abstract:
... Alkaline phosphatase (ALP) is one of the most used enzymes for the diagnosis and monitoring of many diseases. This can be achieved by either detecting ALP as a biomarker or using ALP as the label of enzyme-linked bioassays. ALP-based electrochemical sensors have been considered as promising tools in biosensor devices for POCT systems thanks to their high sensitivity and selectivity, low cost, ease ...
DOI:
10.1039/c8ay02793e

16. Qualitative evaluation of high pH mass spectrometry-compatible reversed phase liquid chromatography for altered selectivity in separations of intact proteins

Author:
Baghdady, Yehia Z.; Schug, Kevin A.
Source:
Journal of chromatography 2019
ISSN:
0021-9673
Subject:
biomarkers,   etc   ; bicarbonates; chromatography; mass spectrometry; neoplasms; pH; proteins; separation; silica;     Show all 9 Subjects
Abstract:
... Intact proteins are increasingly being recognized as potential biomarkers and biotherapeutic agents for cancer and other serious diseases. Low pH reversed phase plays an important role in both single and multidimensional protein separations for resolving complex protein samples prior to mass spectrometric detection. In this work, we evaluated the use of high pH reversed phase liquid chromatography ...
DOI:
10.1016/j.chroma.2019.04.004

17. Structural Factors Enabling Successful GFP-Like Proteins with Alanine as the Third Chromophore-Forming Residue

Author:
Muslinkina, Liya; Roldán-Salgado, Abigail; Gaytán, Paul; Juárez-González, Víctor R.; Rudiño, Enrique; Pletneva, Nadya; Pletnev, Vladimir; Dauter, Zbigniew; Pletnev, Sergei
Source:
Journal of molecular biology 2019 v.431 no.7 pp. 1397-1408
ISSN:
0022-2836
Subject:
biomarkers,   etc   ; alanine; fluorescent proteins; hydrolysis; protein structure; tripeptides;     Show all 6 Subjects
Abstract:
... GFP-like proteins from lancelets (lanFPs) is a new and least studied group that already generated several outstanding biomarkers (mNeonGreen is the brightest FP to date) and has some unique features. Here, we report the study of four homologous lanFPs with GYG and GYA chromophores. Until recently, it was accepted that the third chromophore-forming residue in GFP-like proteins should be glycine, an ...
DOI:
10.1016/j.jmb.2019.02.013

18. The Genetics of Aging: A Vertebrate Perspective

Author:
Singh, Param Priya; Demmitt, Brittany A.; Nath, Ravi D.; Brunet, Anne
Source:
Cell 2019 v.177 no.1 pp. 200-220
ISSN:
0092-8674
Subject:
biomarkers,   etc   ; age; genes; genetics; humans; invertebrates; longevity; mice; models;     Show all 9 Subjects
Abstract:
... Aging negatively impacts vitality and health. Many genetic pathways that regulate aging were discovered in invertebrates. However, the genetics of aging is more complex in vertebrates because of their specialized systems. This Review discusses advances in the genetic regulation of aging in vertebrates from work in mice, humans, and organisms with exceptional lifespans. We highlight challenges for ...
DOI:
10.1016/j.cell.2019.02.038

19. A comparative global proteomic analysis of the hematopoietic lineages in the crustacean Pacifastacus leniusculus

Author:
Söderhäll, Irene; Junkunlo, Kingkamon
Source:
Developmental and comparative immunology 2019 v.92 pp. 170-178
ISSN:
0145-305X
Subject:
biomarkers,   etc   ; Pacifastacus leniusculus; crayfish; hemocytes; microorganisms; proteins; proteomics;     Show all 7 Subjects
Abstract:
... In crustaceans as in other arthropods, the circulating hemocytes are vital for protecting the animal against attacking microorganisms. As many hemocytes are destroyed early during an infection, new hemocytes must fast get in place to prevent disperse of a pathogenic microbe, In order to understand the hematopoietic process in more detail we here report a complete proteomic analysis from purified c ...
DOI:
10.1016/j.dci.2018.11.016

20. Association of macrophage and lymphocyte infiltration with outcome in canine osteosarcoma

Author:
Withers, Sita S.; Skorupski, Katherine A.; York, Daniel; Choi, Jin W.; Woolard, Kevin D.; Laufer‐Amorim, Renee; Sparger, Ellen E.; Rodriguez, Carlos O.; McSorley, Stephen J.; Monjazeb, Arta M.; Murphy, William J.; Canter, Robert J.; Rebhun, Robert B.
Source:
Veterinary and comparative oncology 2019 v.17 no.1 pp. 49-60
ISSN:
1476-5810
Subject:
biomarkers,   etc   ; adjuvants; amputation; dogs; humans; humerus; immunohistochemistry; immunotherapy; macrophages; osteosarcoma;     Show all 10 Subjects
Abstract:
... Immunotherapeutic strategies have shown promise for the treatment of canine osteosarcoma (cOSA). Very little is known about the immune microenvironment within cOSA, however, limiting our ability to identify potential immune targets and biomarkers of therapeutic response. We therefore prospectively assessed the disease‐free interval (DFI) and overall survival time (ST) of 30 dogs with cOSA treated ...
DOI:
10.1111/vco.12444