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1. Relying on repeated biospecimens to reduce the effects of classical-type exposure measurement error in studies linking the exposome to health

Author:
Agier, Lydiane; Slama, Rémy; Basagaña, Xavier
Source:
Environmental research 2020 v.186 pp. 109492
ISSN:
0013-9351
Subject:
biomarkers,   etc   ; calibration; temporal variation;     Show all 3 Subjects
Abstract:
... The exposome calls for assessing numerous exposures, typically using biomarkers with varying amounts of measurement error, which can be assumed to be of classical type. We evaluated the impact of classical-type measurement error on the performance of exposome-health studies, and the efficiency of two measurement error correction methods relying on the collection of repeated biospecimens: within-su ...
DOI:
10.1016/j.envres.2020.109492

2. Saliva sampling: Methods and devices. An overview

Author:
Bellagambi, Francesca G.; Lomonaco, Tommaso; Salvo, Pietro; Vivaldi, Federico; Hangouët, Marie; Ghimenti, Silvia; Biagini, Denise; Di Francesco, Fabio; Fuoco, Roger; Errachid, Abdelhamid
Source:
Trends in analytical chemistry 2020 v.124 pp. 115781
ISSN:
0165-9936
Subject:
biomarkers,   etc   ; blood; medicine; saliva;     Show all 4 Subjects
Abstract:
... The continuous exchange of chemicals with blood and the non-invasive collection make saliva an interesting specimen for clinical applications, from the detection of biomarkers to the new –omic sciences in medicine. However, saliva sampling is challenging because the suitability of the collection method for the analyte of interest is either poorly investigated or, more often, not mentioned at all i ...
DOI:
10.1016/j.trac.2019.115781

3. Benefits of microsampling and microextraction for metabolomics studies

Author:
Hemmati, Maryam; Nix, Cindy; Crommen, Jacques; Servais, Anne-Catherine; Fillet, Marianne
Source:
Trends in analytical chemistry 2020 v.127 pp. 115899
ISSN:
0165-9936
Subject:
biomarkers,   etc   ; detection limit; hydrophilicity; metabolites; metabolomics; microextraction;     Show all 6 Subjects
Abstract:
... The present review deals with the recent developments in metabolome analysis to improve the diagnosis of diseases and the identification of biomarkers. A particular focus has been put on the application of the non-invasive and up-to-date microsampling and microextraction procedures for the targeted/untargeted metabolome analysis from low volume of samples. These approaches aim to enhance sensitivi ...
DOI:
10.1016/j.trac.2020.115899

4. Biomarkers of health and welfare: A One Health perspective from the laboratory side

Author:
Franco-Martínez, Lorena; Martínez-Subiela, Silvia; Cerón, José Joaquín; Tecles, Fernando; Eckersall, Peter David; Oravcova, Katarina; Tvarijonaviciute, Asta
Source:
Research in veterinary science 2020 v.128 pp. 299-307
ISSN:
0034-5288
Subject:
biomarkers,   etc   ; One Health initiative; environmental health; humans;     Show all 4 Subjects
Abstract:
... A biomarker is any measurement reflecting an interaction between a biological system and a potential hazard, which may be chemical, physical, or biological. The One World, One Health concept established that human and animal health and the environmental state are highly interconnected, sharing common aspects that can be applied globally in these three components.In this paper, we review how the co ...
DOI:
10.1016/j.rvsc.2019.12.012

5. Glycosaminoglycans in biological samples – Towards identification of novel biomarkers

Author:
Zhang, Tianji; Zhang, Rui; Lv, Yongqin; Wang, Meng; Li, Hongmei; Tan, Tianwei; Li, Jin-Ping
Source:
Trends in analytical chemistry 2020 v.122 pp. 115732
ISSN:
0165-9936
Subject:
biomarkers,   etc   ; bioactive properties; drugs; glycosaminoglycans; monitoring; pharmacokinetics;     Show all 6 Subjects
Abstract:
... Glycosaminoglycans (GAGs) are unbranched polyanionic polysaccharides involved in a wide spectrum of biological activities. Accumulation and/or structural alteration of GAGs in biological samples have been found correlated with diseases, making these molecules potential biomarkers for the diagnosis of these diseases and monitoring treatment effects. Detection and structural characterization of GAGs ...
DOI:
10.1016/j.trac.2019.115732

6. Analytical techniques for the detection of glycated haemoglobin underlining the sensors

Author:
Sharma, Pradakshina; Panchal, Anupriya; Yadav, Neelam; Narang, Jagriti
Source:
International journal of biological macromolecules 2020 v.155 pp. 685-696
ISSN:
0141-8130
Subject:
biomarkers,   etc   ; analytical methods; blood; blood glucose; diabetes; glucose; hemoglobin;     Show all 7 Subjects
Abstract:
... The increase in concentrations of blood glucose results arise in the proportion of glycated haemoglobin. Therefore, the percentage of glycated haemoglobin in the blood could function as a biomarker for the average glucose level over the past three months and can be used to detect diabetes. The study of glycated haemoglobin tends to be complex as there are about three hundred distinct assay techniq ...
DOI:
10.1016/j.ijbiomac.2020.03.205

7. Changes in cardiac biomarkers in goats naturally affected by pregnancy toxemia

Author:
Souza, L.M.; Mendonça, C.L.; Assis, R.N.; Oliveira Filho, E.F.; Soares, G.S.L.; Souto, R.J.C.; Soares, P.C.; Afonso, J.A.B.
Source:
Research in veterinary science 2020 v.130 pp. 73-78
ISSN:
0034-5288
Subject:
biomarkers,   etc   ; blood serum; cortisol; goats; insulin; metabolic diseases; pregnancy toxemia;     Show all 7 Subjects
Abstract:
... Pregnancy toxemia (PT) is considered one of the most common metabolic diseases with high impact on the production of small ruminants. The objective of this study was investigate possible myocardial damage in goats affected with PT by the determination of serum myocardial biomarkers CK-MB and cTnI. A total of 44 goats affected with PT, and 10 apparently healthy goats (control group or CG) were used ...
DOI:
10.1016/j.rvsc.2020.02.016

8. The role of sampling in wearable sweat sensors

Author:
Liu, Conghui; Xu, Tailin; Wang, Dongdong; Zhang, Xueji
Source:
Talanta 2020 v.212 pp. 120801
ISSN:
0039-9140
Subject:
biomarkers,   etc   ; absorbents; hydrophilicity; hydrophobicity; monitoring; physiology; sampling; sweat;     Show all 8 Subjects
Abstract:
... Wearable sweat sensors demonstrate outstanding performance in non-invasive, real-time monitoring of vital biomarkers in sweat, which offer an opportunity for individuals to achieve dynamic monitoring their own physiology in molecular-level. As a key step in sweat analysis that impact the accuracy of results, frequently-used sweat sampling methods are introduced in this review, and the emphasis is ...
DOI:
10.1016/j.talanta.2020.120801

9. From laboratory to clinic: Translation of extracellular vesicle based cancer biomarkers

Author:
Yekula, Anudeep; Muralidharan, Koushik; Kang, Keiko M.; Wang, Lan; Balaj, Leonora; Carter, Bob S.
Source:
Methods 2020 v.177 pp. 58-66
ISSN:
1046-2023
Subject:
biomarkers,   etc   ; biomedical research; monitoring; nanoparticles; neoplasms; patient care;     Show all 6 Subjects
Abstract:
... The past decade has witnessed a rapid growth in the field of extracellular vesicle (EV) based biomarkers for the diagnosis and monitoring of cancer. Several studies have reported novel EV based biomarkers, but the technical and clinical validation phase has been hampered by general challenges common to biomedical research field as well as specific challenges inherent to the nanoparticle field. Thi ...
DOI:
10.1016/j.ymeth.2020.02.003
PubMed:
32061674
PubMed Central:
PMC7198349

10. Multiple analyte profiling (MAP) index as a powerful diagnostic and therapeutic monitoring tool

Author:
Elsabahy, Mahmoud; Wooley, Karen L.; Hendricksen, Amy; Oh, Kenneth
Source:
Methods 2020
ISSN:
1046-2023
Subject:
biomarkers,   etc   ; algorithms; breast neoplasms; disease models; monitoring; therapeutics;     Show all 6 Subjects
Abstract:
... A robust data mining algorithm is presented as a critical solution to the challenge of managing intensive data generated from the recently developed multiplexing techniques, which allow simultaneous detection of up to 500 biomarkers in a few microliters of a single sample. Furthermore, detailed methodology is provided for exploiting the new algorithm along with examples for description of the firs ...
DOI:
10.1016/j.ymeth.2020.03.006

11. Considerations for assessing stability of wastewater-based epidemiology biomarkers using biofilm-free and sewer reactor tests

Author:
Choi, Phil Min; Li, Jiaying; Gao, Jianfa; O'Brien, Jake William; Thomas, Kevin Victor; Thai, Phong Khanh; Jiang, Guangming; Mueller, Jochen Friedrich
Source:
The Science of the total environment 2020 v.709 pp. 136228
ISSN:
0048-9697
Subject:
biomarkers,   etc   ; biofilm; drugs; epidemiology; metabolites; sewer systems; wastewater;     Show all 7 Subjects
Abstract:
... Wastewater-based epidemiology is an increasingly popular method for analysing drugs or metabolites excreted by populations. The in-sewer transformation of biomarkers is important but often receives little consideration in published studies. Many studies publish stability under biofilm-free conditions only, which do not represent actual sewer conditions. This study aims to fill a gap in the field b ...
DOI:
10.1016/j.scitotenv.2019.136228

12. Recent advances in high-sensitivity detection methods for paper-based lateral-flow assay

Author:
Nguyen, Van-Thuan; Song, Seungri; Park, Seungkyung; Joo, Chulmin
Source:
Biosensors & bioelectronics 2020 v.152 pp. 112015
ISSN:
0956-5663
Subject:
biomarkers,   etc   ; biosensors; color; commercialization; detection limit; diagnostic techniques; environmental monitoring;     Show all 7 Subjects
Abstract:
... Paper-based lateral-flow assays (LFAs) have achieved considerable commercial success and continue to have a significant impact on medical diagnostics and environmental monitoring. Conventional LFAs are typically performed by examining the color changes in the test bands by naked eye. However, for critical biochemical markers that are present in extremely small amounts in the clinical specimens, th ...
DOI:
10.1016/j.bios.2020.112015

13. Improved Method for n-Alkanes and n-Methyl-Ketones Determination in Litters and Soils

Author:
Zavgorodnyaya, Yu. A.; Anokhina, N. A.; Bogatyrev, L. G.; Demin, V. V.
Source:
Eurasian soil science 2020 v.53 no.3 pp. 310-316
ISSN:
1064-2293
Subject:
biomarkers,   etc   ; alkanes; chloroform; forest litter; lipids; methanol; solvents; temperature;     Show all 8 Subjects
Abstract:
... A new technique to extract lipid biomarkers (n-alkanes and n-methyl-ketones) from forest litters and soils using the accelerated solvent extraction (ASE) method was developed. The maximum output of n-alkanes and n-methyl-ketones was obtained by sequential extraction using the chloroform : methanol mixture [3 : 1 (vol)] in the first two extraction cycles and chloroform in the subsequent two cycles. ...
DOI:
10.1134/S1064229320030114

14. Mini-pillar microarray for individually electrochemical sensing in microdroplets

Author:
Song, Yongchao; Xu, Tailin; Xiu, Jidong; Zhang, Xueji
Source:
Biosensors & bioelectronics 2020 v.149 pp. 111845
ISSN:
0956-5663
Subject:
biomarkers,   etc   ; adhesion; biosensors; deformation; drugs; electrochemistry; electrodes; glucose; microarray technology;     Show all 9 Subjects
Abstract:
... High throughput and high sensitivity are two important aspects in multiple biomarker recognition, drug discovery and relevant biochemical sensing. Here, we integrate mini-pillar microarray with the circuit components toward high-throughput individual electrochemical sensing in microdroplets. On such droplet-microarray-based electrochemical platform, the high adhesion of the mini-pillar can hold a ...
DOI:
10.1016/j.bios.2019.111845

15. Advances in biosensing technologies for analysis of cancer-derived exosomes

Author:
Xu, Huiying; Ye, Bang-Ce
Source:
Trends in analytical chemistry 2020 v.123 pp. 115773
ISSN:
0165-9936
Subject:
biomarkers,   etc   ; biosensors; exosomes; monitoring; neoplasm cells; neoplasms; signal transduction; therapeutics;     Show all 8 Subjects
Abstract:
... Exosomes play an important role in intercellular communication that contribute to the interaction of cancer cells with the tumor microenvironment. The original features endow tumor-derived exosomes with distinctive opportunities to serve as sensitive biomarkers for identifying early-stage tumors and monitoring of therapeutic response non-invasively. Conventional detection techniques face a number ...
DOI:
10.1016/j.trac.2019.115773

16. Correction to: Urinary metabolites of polycyclic aromatic hydrocarbons in pregnant women and their association with a biomarker of oxidative stress

Author:
Lou, Xiang-Ying; Wu, Peng-Ran; Guo, Ying
Source:
Environmental science and pollution research international 2020 v.27 no.4 pp. 4551
ISSN:
0944-1344
Subject:
biomarkers,   etc   ; metabolites; oxidative stress; polycyclic aromatic hydrocarbons; pregnant women;     Show all 5 Subjects
Abstract:
... The correct name of the 1ˢᵗ Author is shown in this paper. ...
DOI:
10.1007/s11356-019-06977-z

17. Recent advances in electrochemiluminescence-based simultaneous detection of multiple targets

Author:
Lv, Wanxue; Ye, Haochen; Yuan, Zhiqin; Liu, Xuejiao; Chen, Xu; Yang, Wensheng
Source:
Trends in analytical chemistry 2020 v.123 pp. 115767
ISSN:
0165-9936
Subject:
biomarkers,   etc   ; electrochemiluminescence; microRNA; neoplasm cells; neoplasms; prediction; proteins;     Show all 7 Subjects
Abstract:
... The electrochemiluminescence (ECL)-based simultaneous detection of multiple biomarkers in one sample has received considerable attention in the past decade due to the increasing need for accurate cancer diagnosis and prediction. However, there has not been a comprehensive summary of ECL-based simultaneous detection of multiple biomarkers. In this review, we focus on recent advances in multiplex EC ...
DOI:
10.1016/j.trac.2019.115767

18. Paper-based lateral flow strip assay for the detection of foodborne pathogens: principles, applications, technological challenges and opportunities

Author:
Luo, Ke; Kim, Hae-Yeong; Oh, Mi-Hwa; Kim, Young-Rok
Source:
Critical reviews in food science and nutrition 2020 v.60 no.1 pp. 157-170
ISSN:
1549-7852
Subject:
biomarkers,   etc   ; food pathogens; polymerase chain reaction; virulent strains;     Show all 4 Subjects
Abstract:
... As a representative colorimetic biosnesor, paper-based LFSA have emerged as a promising and robust tool that can easily and instansly detect the presence of target biological components in food sample. Recently, LFSAs have gained a considerable attention as an alternative method for rapid diagnosis of foodborne pathogens to the conventional culture-based assays such as plate counting and PCR. One ...
DOI:
10.1080/10408398.2018.1516623

19. Current Trends in the Analysis of Post-translational Modifications

Author:
Virág, Dávid; Dalmadi-Kiss, Borbála; Vékey, Károly; Drahos, László; Klebovich, Imre; Antal, István; Ludányi, Krisztina
Source:
Chromatographia 2020 v.83 no.1 pp. 1-10
ISSN:
0009-5893
Subject:
biomarkers,   etc   ; biopharmaceuticals; chromatography; mass spectrometry; post-translational modification; quantitative analysis;     Show all 6 Subjects
Abstract:
... Post-translational modifications controlling a large number of biological functions are key aspects of protein diversity. They have an important role controlling cellular processes and may be advantageously utilized. Qualitative and quantitative analyses of post-translational modifications are useful for biomarker research and an integral part of the characterization of protein biopharmaceuticals. ...
DOI:
10.1007/s10337-019-03796-9

20. Grade-specific diagnostic and prognostic biomarkers in breast cancer

Author:
Jayanthi, V.S.P.K. Sankara Aditya; Das, Asim Bikas; Saxena, Urmila
Source:
Genomics 2020 v.112 no.1 pp. 388-396
ISSN:
0888-7543
Subject:
biomarkers,   etc   ; breast neoplasms; genes; metastasis; patients; phenotype; prognosis;     Show all 7 Subjects
Abstract:
... An integrative approach is presented to identify grade-specific biomarkers for breast cancer. Grade-specific molecular interaction networks were constructed with differentially expressed genes (DEGs) of cancer grade 1, 2, and 3. We observed that the molecular network of grade3 is predominantly associated with cancer-specific processes. Among the top ten connected DEGs in the grade3, the increase i ...
DOI:
10.1016/j.ygeno.2019.03.001