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1. Protein measurements in venous plasma, earlobe capillary plasma and in plasma stored on filter paper

Author:
Siart, Benjamin; de Oliveira, Felipe Marques Souza; Shen, Qiujin; Björkesten, Johan; Pekar, Thomas; Steinborn, Ralf; Nimmerichter, Alfred; Kamali-Moghaddam, Masood; Wallner, Bernard
Source:
Analytical biochemistry 2019 v.566 pp. 146-150
ISSN:
0003-2697
Subject:
biomarkers,   etc   ; blood; chemical species; males; proteins;     Show all 5 Subjects
Abstract:
... In this study, levels of inflammatory protein biomarkers in venous plasma, plasma derived from capillary blood from the earlobe, and capillary plasma stored as dried plasma spots (DPS) were compared. Samples from 12 male individuals were assessed with a panel of 92 inflammation-related proteins using multiplex proximity extension assay. Correlations between sample types varied greatly between anal ...
DOI:
10.1016/j.ab.2018.11.016

2. Correction to: The P/N (Positive-to-Negative Links) Ratio in Complex Networks—A Promising In Silico Biomarker for Detecting Changes Occurring in the Human Microbiome

Author:
Ma, Zhanshan(Sam)
Source:
Microbial ecology 2018 v.75 no.4 pp. 1074
ISSN:
0095-3628
Subject:
biomarkers,   etc   ; humans; microbiome;     Show all 3 Subjects
Abstract:
... The original version of this article unfortunately contained a missing image. The flowchart was not captured in PDF version. The original article was corrected. ...
DOI:
10.1007/s00248-017-1107-7

3. Health, pre-disease and critical transition to disease in the psycho-immune-neuroendocrine network: Are there distinct states in the progression from health to major depressive disorder?

Author:
Stapelberg, N.J.C.; Neumann, D.L.; Shum, D.; Headrick, J.P.
Source:
Physiology & behavior 2019 v.198 pp. 108-119
ISSN:
0031-9384
Subject:
biomarkers,   etc   ; chronic diseases; disease susceptibility; mental depression; models; risk;     Show all 6 Subjects
Abstract:
... The psycho-immune-neuroendocrine (PINE) network is a regulatory network of interrelated physiological pathways that have been implicated in major depressive disorder (MDD). A model of disease progression for MDD is presented where the stable, healthy state of the PINE network (PINE physiome) undergoes progressive pathophysiological changes to an unstable but reversible pre-disease state (PINE pre- ...
DOI:
10.1016/j.physbeh.2018.10.014

4. What are the current analytical approaches for sediment analysis related to the study of diagenesis? Highlights from 2010 to 2018

Author:
Kuznetsova, O.V.; Sevastyanov, V.S.; Timerbaev, A.R.
Source:
Talanta 2019 v.191 pp. 435-442
ISSN:
0039-9140
Subject:
biomarkers,   etc   ; chemical species; diagenesis; mass spectrometry; organic matter; sediments;     Show all 6 Subjects
Abstract:
... This review is aimed at critical analysis of current and emerging capabilities of analytical methods as employed for sediment analysis. An emphasis is given to the most reliable experimental strategies used to acquiring analytical information that is relevant to study the diagenetic processes affecting the composition of sediments. Advanced analytical methodology in use basically rely on the appli ...
DOI:
10.1016/j.talanta.2018.08.080

5. Lacustrine brGDGT response to microcosm and mesocosm incubations

Author:
Martínez-Sosa, Pablo; Tierney, Jessica E.
Source:
Organic geochemistry 2019 v.127 pp. 12-22
ISSN:
0146-6380
Subject:
biomarkers,   etc   ; carbon; glycerol; heterotrophs; isomerization; methylation; nutrients; oxygen; temperature;     Show all 9 Subjects
Abstract:
... Branched dialkyl glycerol tetraethers (brGDGTs) are increasingly used as a paleotemperature proxy, yet the microbial producers of these compounds and the way they respond to environmental perturbations remain poorly understood. In this work, we used mesocosms to track the evolution of brGDGTs over several months, as well as an array of microcosms to study microbial brGDGT response to oxygen availa ...
DOI:
10.1016/j.orggeochem.2018.10.011

6. Correction to: Characterization of biomarkers in stroke based on ego-networks and pathways

Author:
Li, Haixia; Guo, Qian
Source:
Biotechnology letters 2018 v.40 no.9-10 pp. 1437
ISSN:
0141-5492
Subject:
biomarkers,   etc   ; biotechnology; human diseases; stroke;     Show all 4 Subjects
Abstract:
... In the original publication of the article, the second author name was published incorrectly. The corrected author name is given in this correction. ...
DOI:
10.1007/s10529-018-2590-8

7. GFP fluorescence: A few lesser-known nuggets that make it work

Author:
Sarkar, Parijat; Chattopadhyay, Amitabha
Source:
Journal of biosciences 2018 v.43 no.3 pp. 421-430
ISSN:
0250-5991
Subject:
biomarkers,   etc   ; fluorescence; green fluorescent protein;     Show all 3 Subjects
Abstract:
... Use of Green Fluorescent Protein (GFP) as a marker has revolutionized biological research in the last few decades. In this brief commentary, we reflect upon the success story of GFP and highlight a few lesser-known facets about GFP that add up to its usefulness. ...
DOI:
10.1007/s12038-018-9779-9

8. Covariate‐adjusted Spearman's rank correlation with probability‐scale residuals

Author:
Liu, Qi; Li, Chun; Wanga, Valentine; Shepherd, Bryan E.
Source:
Biometrics 2018 v.74 no.2 pp. 595-605
ISSN:
0006-341X
Subject:
biomarkers,   etc   ; biometry; models; probability; surveys;     Show all 5 Subjects
Abstract:
... It is desirable to adjust Spearman's rank correlation for covariates, yet existing approaches have limitations. For example, the traditionally defined partial Spearman's correlation does not have a sensible population parameter, and the conditional Spearman's correlation defined with copulas cannot be easily generalized to discrete variables. We define population parameters for both partial and co ...
DOI:
10.1111/biom.12812

9. A series of BODIPY-based probes for the detection of cysteine and homocysteine in living cells

Author:
Wang, Nannan; Chen, Miao; Gao, Jinhua; Ji, Xin; He, Jinling; Zhang, Jian; Zhao, Weili
Source:
Talanta 2019 v.195 pp. 281-289
ISSN:
0039-9140
Subject:
biomarkers,   etc   ; cysteine; disease course; early diagnosis; fluorescent dyes; glutathione; homocysteine; image analysis;     Show all 8 Subjects
Abstract:
... Biothiols, such as glutathione (GSH), homocysteine (Hcy) and cysteine (Cys), are important biomarkers and play crucial roles in many physiological processes. Thus, the detection of biothiols is highly important for early diagnosis of diseases and evaluation of disease progression. Herein, new types of BODIPY-based fluorescent probes (probe 1, probe 2 and probe 3) capable of cysteine (Cys)/homocyst ...
DOI:
10.1016/j.talanta.2018.11.066

10. Blood lead, bone lead and child attention-deficit-hyperactivity-disorder-like behavior

Author:
Lin, Yanfen; Huang, Lihua; Xu, Jian; Specht, Aaron J.; Yan, Chonghuai; Geng, Hongquan; Shen, Xiaoming; Nie, Linda H.; Hu, Howard
Source:
The Science of the total environment 2019 v.659 pp. 161-167
ISSN:
0048-9697
Subject:
biomarkers,   etc   ; blood; bones; children; comorbidity; cumulative exposure; epidemiological studies; lead; regression analysis; risk factors;     Show all 10 Subjects
Abstract:
... Mounting evidence showed that lead exposure increased the risk of child attention-deficit-hyperactivity disorder (ADHD). Epidemiologic studies have typically used the blood-lead as a biomarker of lead exposure; blood-lead levels mostly reflect recent lead exposure. However, few studies have examined the relationship between bone-lead, a biomarker of cumulative exposure, and ADHD. Therefore, we aim ...
DOI:
10.1016/j.scitotenv.2018.12.219

11. Nanoscale fluorescent metal–organic framework composites as a logic platform for potential diagnosis of asthma

Author:
Zhang, Xin; Fang, Liquan; Jiang, Ke; He, Huajun; Yang, Yu; Cui, Yuanjing; Li, Bin; Qian, Guodong
Source:
Biosensors & bioelectronics 2019 v.130 pp. 65-72
ISSN:
0956-5663
Subject:
biomarkers,   etc   ; asthma; biocompatibility; blood serum; coordination polymers; cytotoxicity; detection limit; fluorescence; hydrogen sulfide; lungs; monitoring; silver;     Show all 12 Subjects
Abstract:
... Asthma is a common chronic disorder, and the decreased hydrogen sulfide (H2S) production in the lung has been considered as an early detection biomarker for asthma. However, the detection of H2S in biological systems remains a challenge; because it requires the designed sensors to have the following features: nanoscale size, good biocompatibility, real-time detection, high selectivity/sensitivity, ...
DOI:
10.1016/j.bios.2019.01.011

12. A flyover style microfluidic chip for highly purified magnetic cell separation

Author:
Lin, Shujing; Zhi, Xiao; Chen, Di; Xia, Fangfang; Shen, Yihuan; Niu, Jiaqi; Huang, Shiyi; Song, Jie; Miao, Jianmin; Cui, Daxiang; Ding, Xianting
Source:
Biosensors & bioelectronics 2019 v.129 pp. 175-181
ISSN:
0956-5663
Subject:
biomarkers,   etc   ; biosensors; leukocytes; magnetic separation; magnetism; microfluidic technology; neoplasms; organ-on-a-chip; prognosis; viability;     Show all 10 Subjects
Abstract:
... White blood cells (WBCs) isolated from peripheral blood have been verified as important biomarkers for the diagnosis, treatment and prognosis of cancer. However, it’s still under challenge to acquire high-purity WBCs, even by taking advantage of current microfluidic technology. Considering the universality of clinical magnetic activated cell sorting (MACS) method, new developments on microfluidic ...
DOI:
10.1016/j.bios.2018.12.058

13. Systematic evaluation of biomarker stability in pilot scale sewer pipes

Author:
Gao, Jianfa; Li, Jiaying; Jiang, Guangming; Shypanski, Adam H.; Nieradzik, Ludwika M.; Yuan, Zhiguo; Mueller, Jochen F.; Ort, Christoph; Thai, Phong K.
Source:
Water research 2019 v.151 pp. 447-455
ISSN:
0043-1354
Subject:
biomarkers,   etc   ; acetaminophen; buprenorphine; caffeine; epidemiology; gravity; methadone; models; pipes; salicylic acid; sewer systems; wastewater;     Show all 12 Subjects
Abstract:
... Transformation of biomarkers (or their stability) during sewer transport is an important issue for wastewater-based epidemiology (WBE). Most studies so far have been conducted in the laboratory, which usually employed unrealistic conditions. In the present study, we utilized a pilot sewer system including a gravity pipe and a rising main pipe to investigate the fate of 24 pharmaceutical biomarkers ...
DOI:
10.1016/j.watres.2018.12.032

14. Bioassay of saliva proteins: The best alternative for conventional methods in non-invasive diagnosis of cancer

Author:
Eftekhari, Aziz; Hasanzadeh, Mohammad; Sharifi, Simin; Dizaj, Solmaz Maleki; Khalilov, Rovshan; Ahmadian, Elham
Source:
International journal of biological macromolecules 2019 v.124 pp. 1246-1255
ISSN:
0141-8130
Subject:
biomarkers,   etc   ; Internet; aptasensors; bioassays; cost effectiveness; databases; diagnostic techniques; electrochemistry; neoplasms; patients; proteins; saliva;     Show all 12 Subjects
Abstract:
... Non-invasive diagnosis of cancer is often the key to effective treatment and patient survival. Saliva as a multi-constituent oral fluid comprises various disease signaling biomarkers, holds great potential for early-stage cancer diagnostics with cost-effective and easy collection, storage, transport and processing. Therefore, detection of biomarkers and proteins in the saliva samples is highly dem ...
DOI:
10.1016/j.ijbiomac.2018.11.277

15. New myeloperoxidase detection system based on enzyme-catalysed oxidative synthesis of a dye for paper-based diagnostic devices

Author:
Bassegoda, Arnau; Ferreres, Guillem; Pérez-Rafael, Sílvia; Hinojosa-Caballero, Dolores; Torrent-Burgués, Juan; Tzanov, Tzanko
Source:
Talanta 2019 v.194 pp. 469-474
ISSN:
0039-9140
Subject:
biomarkers,   etc   ; color; diagnostic techniques; dyes; myeloperoxidase; oxidation; paper; point-of-care testing; polyethyleneimine;     Show all 9 Subjects
Abstract:
... The severity and cost of wound infections strongly demands for simple and fast methods for wound infection determination. Point-of-care testing devices play a crucial role in order to achieve a fast diagnosis and early treatment. Myeloperoxidase (MPO) enzyme, detected in fluids of infected wounds has been postulated as a suitable biomarker for wound diagnostics. Here we present a new system for MP ...
DOI:
10.1016/j.talanta.2018.10.065

16. Rolling circle extension-actuated loop-mediated isothermal amplification (RCA-LAMP) for ultrasensitive detection of microRNAs

Author:
Tian, Weimin; Li, Pengjie; He, Wenli; Liu, Chenghui; Li, Zhengping
Source:
Biosensors & bioelectronics 2019 v.128 pp. 17-22
ISSN:
0956-5663
Subject:
biomarkers,   etc   ; DNA; biosensors; detection limit; gene amplification; loop-mediated isothermal amplification; microRNA;     Show all 7 Subjects
Abstract:
... Rolling circle amplification (RCA) is an elegant and well-recognized isothermal nucleic acid amplification mechanism that has been widely used for the detection of various kinds of genetic biomarkers. However, traditional RCA is a linear signal amplifying mechanism so that the amplification efficiency is generally not satisfactory. Herein, we rationally combine RCA with efficient loop-mediated iso ...
DOI:
10.1016/j.bios.2018.12.041

17. Associations between inhaled doses of PM2.5-bound polycyclic aromatic hydrocarbons and fractional exhaled nitric oxide

Author:
Li, Tian; Wang, Yao; Hou, Jian; Zheng, Dan; Wang, Guiyang; Hu, Chen; Xu, Tian; Cheng, Juan; Yin, Wenjun; Mao, Xiang; Wang, Lin; He, Zhenyu; Yuan, Jing
Source:
Chemosphere 2019 v.218 pp. 992-1001
ISSN:
0045-6535
Subject:
biomarkers,   etc   ; acute exposure; air; breathing; nitric oxide; particulates; polycyclic aromatic hydrocarbons; regression analysis; students; China;     Show all 10 Subjects
Abstract:
... Exposure to fine particulate matter (PM2.5) is linked to various respiratory outcomes. However, the associations of concentrations of PM2.5-bound polycyclic aromatic hydrocarbons (PM2.5-bound PAHs) with airway inflammatory indices remains unclear. To assess effects of short-term exposure to PM2.5-bound PAHs on fractional exhaled nitric oxide (FeNO), we conducted a pilot study with repeated measure ...
DOI:
10.1016/j.chemosphere.2018.11.196

18. Manganese levels in newborns’ hair by maternal sociodemographic, dietary and environmental factors

Author:
Irizar, A.; Gil, F.; Lertxundi, A.; Martín-Domingo, M.C.; Urbieta, N.; Molinuevo, A.; Ibarluzea, J.; Basterrechea, M.; Aurrekoetxea, J.J.; Jiménez-Zabala, A.; Santa-Marina, L.
Source:
Environmental research 2019 v.170 pp. 92-100
ISSN:
0013-9351
Subject:
biomarkers,   etc   ; air pollution; children; environmental factors; manganese; maternal exposure; neonates; particulates; pasta; pregnancy; pregnant women; questionnaires;     Show all 12 Subjects
Abstract:
... Exposure to manganese (Mn) has been associated with neurodevelopmental problems in children. Mn exposure begins in utero, and maternal sociodemographic, dietary and environmental factors may affect Mn levels in newborns’ hair. This study aimed to characterize in utero Mn exposure using Mn levels in newborns’ hair as a biomarker of prenatal exposure, and to analyze its relationship with sociodemogr ...
DOI:
10.1016/j.envres.2018.11.038

19. Field effect in molecule-gated switches and the role of target-to-receptor size ratio in biosensor sensitivity

Author:
Garrote, Beatriz L.; Fernandes, Flavio C.B.; Cilli, Eduardo M.; Bueno, Paulo R.
Source:
Biosensors & bioelectronics 2019 v.127 pp. 215-220
ISSN:
0956-5663
Subject:
biomarkers,   etc   ; Parkinson disease; biosensors; dengue; electrochemistry; heart; inflammation; moieties; neoplasms; risk assessment; screening; transistors;     Show all 12 Subjects
Abstract:
... We demonstrated here that molecular redox films are electrochemical capacitive devices possessing specific field effect in which molecular moieties within films act as sensitive gates. We confirm that the field effect present in these redox switches is suitable in detecting, in a label-free manner (without needs of redox probe in the biological samples), biomarkers of essential importance for deng ...
DOI:
10.1016/j.bios.2018.12.018

20. An electric potential modulated cascade of catalyzed hairpin assembly and rolling chain amplification for microRNA detection

Author:
Wang, Shuang; Lu, Shasha; Zhao, Jiahui; Ye, Jing; Huang, Jianshe; Yang, Xiurong
Source:
Biosensors & bioelectronics 2019 v.126 pp. 565-571
ISSN:
0956-5663
Subject:
biomarkers,   etc   ; biosensors; catalytic activity; detection limit; diagnostic techniques; electric potential; electrodes; genes; microRNA; transcription (genetics);     Show all 10 Subjects
Abstract:
... MicroRNAs serve as a new type of biomarker for multifarious diseases due to its critical roles in post transcriptional gene regulation. Herein, we firstly integrate the catalyzed hairpin assembly (CHA) and rolling circle amplification (RCA) into an electrochemical biosensor for sensitive and specific detection of miR-21. Meanwhile, an electric potential was employed to modulate the efficiency of C ...
DOI:
10.1016/j.bios.2018.09.088