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1. The leucine‐rich repeat signaling scaffolds Shoc2 and Erbin: cellular mechanism and role in disease

Author:
Jang, HyeIn; Stevens, Payton; Gao, Tianyan; Galperin, Emilia
Source:
TheFEBS journal 2021 v.288 no.3 pp. 721-739
ISSN:
1742-464X
Subject:
biomarkers,   etc   ; humans; therapeutics;     Show all 3 Subjects
Abstract:
... Leucine‐rich repeat‐containing proteins (LRR proteins) are involved in supporting a large number of cellular functions. In this review, we summarize recent advancements in understanding functions of the LRR proteins as signaling scaffolds. In particular, we explore what we have learned about the mechanisms of action of the LRR scaffolds Shoc2 and Erbin and their roles in normal development and dis ...
DOI:
10.1111/febs.15450

2. Ultra-sensitive reusable SERS sensor for multiple hazardous materials detection on single platform

Author:
Naqvi, Tania K.; Bajpai, Abhilash; Bharati, Moram Sree Satya; Kulkarni, Manish M.; Siddiqui, Azher M.; Soma, Venugopal Rao; Dwivedi, Prabhat K.
Source:
Journal of hazardous materials 2021 v.407 pp. 124353
ISSN:
0304-3894
Subject:
biomarkers,   etc   ; Bacillus anthracis; chemical species;     Show all 3 Subjects
Abstract:
... We demonstrate the detection of dipicolinic acid, (DPA), a biomarker of bacterial spores for Bacillus anthracis, 2,4-Dinitrotoluene (DNT) and picric acid (PA) nitroaromatic hazardous chemicals on ultra-sensitive, reusable femtosecond laser textured Au nanostructures decorated with hierarchical AuNPs as a SERS substrate. The AuNPs were achieved by ablating an Au sheet using two different laser scan ...
DOI:
10.1016/j.jhazmat.2020.124353

3. Advances in multiplexed techniques for the detection and quantification of microRNAs

Author:
Jet, Thomas; Gines, Guillaume; Rondelez, Yannick; Taly, Valérie
Source:
Chemical Society reviews 2021 v.50 no.6 pp. 4141-4161
ISSN:
1460-4744
Subject:
biomarkers,   etc   ; analytical chemistry; liquids; microRNA;     Show all 4 Subjects
Abstract:
... MicroRNA detection is currently a crucial analytical chemistry challenge: almost 2000 papers were referenced in PubMed in 2018 and 2019 for the keywords “miRNA detection method”. MicroRNAs are potential biomarkers for multiple diseases including cancers, neurodegenerative and cardiovascular diseases. Since miRNAs are stably released in bodily fluids, they are of prime interest for the development ...
DOI:
10.1039/d0cs00609b

4. 1,2-DCA Natural Attenuation Evaluation in Groundwater: Insight by Dual Isotope 13C/37Cl and Molecular Analysis Approach

Author:
Carpani, Giovanna; Marchesi, Massimo; Pietrini, Ilaria; Alberti, Luca; Zaninetta, Luciano Massimo; Shouakar-Stash, Orfan; de Ferra, Francesca
Source:
Water 2021 v.13 no.5
ISSN:
2073-4441
Subject:
biomarkers,   etc   ; ; Geobacter; biodegradation; groundwater; remediation;     Show all 6 Subjects
Abstract:
... Natural attenuation (NA) processes represent a valuable option in groundwater remediation. At a heavily 1,2-dichloroethane (1,2-DCA) contaminated site, Compound-Specific Isotope Analysis (CSIA) in combination with Biological Molecular Tools (BMTs) were implemented as a rigorous characterization approach to evaluate the occurrence of Natural Attenuation in the proximity of the source area. By the u ...
DOI:
10.3390/w13050728

5. Ultrasensitive electrochemical assay for microRNA-21 based on CRISPR/Cas13a-assisted catalytic hairpin assembly

Author:
Cui, Ying; Fan, Shanji; Yuan, Ze; Song, Minghui; Hu, Jiawen; Qian, Dong; Zhen, Deshuai; Li, Junhua; Zhu, Baode
Source:
Talanta 2021 v.224 pp. 121878
ISSN:
0039-9140
Subject:
biomarkers,   etc   ; assays; electrochemistry; microRNA; therapeutics;     Show all 5 Subjects
Abstract:
... MicroRNAs (miRNAs) are related to many biological processes and regarded as biomarkers of disease. Rapid, sensitive, and specific methods for miRNA assay are very important for early disease diagnostic and therapy. In the present work, an ultrasensitive electrochemical biosensing platform has been developed for miRNA-21 assay by combining CRISPR-Cas13a system and catalytic hairpin assembly (CHA). ...
DOI:
10.1016/j.talanta.2020.121878

6. Efficient screening of predictive biomarkers for individual treatment selection

Author:
Sugasawa, Shonosuke; Noma, Hisashi
Source:
Biometrics 2021 v.77 no.1 pp. 249-257
ISSN:
0006-341X
Subject:
biomarkers,   etc   ; breast neoplasms; precision medicine;     Show all 3 Subjects
Abstract:
... The development of molecular diagnostic tools to achieve individualized medicine requires identifying predictive biomarkers associated with subgroups of individuals who might receive beneficial or harmful effects from different available treatments. However, due to the large number of candidate biomarkers in the large‐scale genetic and molecular studies, and complex relationships among clinical ou ...
DOI:
10.1111/biom.13279

7. Biomarkers and Nutrients in Musculoskeletal Disorders

Author:
Calvo-Lobo, César; Becerro-de-Bengoa-Vallejo, Ricardo; Losa-Iglesias, Marta Elena; Rodríguez-Sanz, David; López-López, Daniel; San-Antolín, Marta
Source:
Nutrients 2021 v.13 no.2
ISSN:
2072-6643
Subject:
biomarkers,   etc   ; administrative management; musculoskeletal system;     Show all 3 Subjects
Abstract:
... Worldwide, the burden of musculoskeletal disorders is increasing with great variations between-countries, which makes it difficult for policymakers to provide resources and adequate interventions in order to provide for their appropriate management [...] ...
DOI:
10.3390/nu13020283

8. Prognostic value of immune-related cells and genes in the tumor microenvironment of ovarian cancer, especially CST4

Author:
Wang, Shuang; Wang, Caixia; Liu, Ouxuan; Hu, Yuexin; Li, Xiao; Lin, Bei
Source:
Life sciences 2021 v.277 pp. 119461
ISSN:
0024-3205
Subject:
biomarkers,   etc   ; genes; immunotherapy; mortality; ovarian neoplasms;     Show all 5 Subjects
Abstract:
... Ovarian cancer (OC) is the most common gynecological malignant tumor with the highest mortality rate. However, identification of effective immune therapeutic targets and biomarkers are beset by many challenges. CIBERSORT was used to calculate the abundance of 22 immune cell types in 379 OC samples, and indicated that three immune cell types were associated with poor prognoses. Further analysis rev ...
DOI:
10.1016/j.lfs.2021.119461

9. Development and application of novel immunoassays for eosinophil granule major basic proteins to evaluate eosinophilia and myeloproliferative disorders

Author:
Squillace, Diane L.; Checkel, James L.; Tefferi, Ayalew; Kita, Hirohito; Gleich, Gerald J.
Source:
Journal of immunological methods 2021 v.493 pp. 113015
ISSN:
0022-1759
Subject:
biomarkers,   etc   ; blood serum; eosinophilia; humans; nose; radioimmunoassays;     Show all 6 Subjects
Abstract:
... During eosinophil differentiation, the granule eosinophil major basic protein 1 (eMBP1) is synthesized as a 32-kDa precursor form, referred to as proMBP1, which is processed into the 14-kDa mature form of eMBP1. The prevalence of these two forms of MBP1 in most pathological conditions remains unknown.To develop the immunoassays that differentiate mature eMBP1 and proMBP1 and apply them to analyze ...
DOI:
10.1016/j.jim.2021.113015

10. Measurement of ITIH4 and Hp levels in bitches with pyometra using newly developed ELISA methods

Author:
Soler, Lourdes; Szczubiał, Marek; Dąbrowski, Roman; Płusa, Anna; Bochniarz, Mariola; Brodzki, Piotr; Lampreave, Fermín; Piñeiro, Matilde
Source:
Veterinary immunology and immunopathology 2021 v.235 pp. 110221
ISSN:
0165-2427
Subject:
biomarkers,   etc   ; blood serum; haptoglobins; immunopathology; medicine; pyometra;     Show all 6 Subjects
Abstract:
... Measurement of acute phase proteins (APPs) as biomarkers in canine medicine is in increasing demand. In the present study, the development and validation of two ELISA methods for the quantification of canine inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) and haptoglobin (Hp) are shown. The adequate imprecision and accuracy and wide analytical range make the developed methods appropriate to qu ...
DOI:
10.1016/j.vetimm.2021.110221

11. Functionalized nanoprobes for in situ detection of telomerase

Author:
Yu, Zhengze; Jiang, Fan; Hu, Chenchen; Tang, Bo
Source:
Chemical communications 2021 v.57 no.31 pp. 3736-3748
ISSN:
1364-548X
Subject:
biomarkers,   etc   ; cell proliferation; prognosis; ribonucleoproteins; telomerase; telomeres;     Show all 6 Subjects
Abstract:
... Telomerase, a special ribonucleoprotein reverse transcriptase, can maintain the length and stability of telomeres and plays an important role in cell proliferation and differentiation. Due to the distinguishable expression level in normal cells and cancer cells, telomerase has become an important biomarker for cancer diagnosis and prognosis evaluation. Despite major breakthroughs in the field of t ...
DOI:
10.1039/d0cc08412c

12. R-catcher, a potent molecular tool to unveil the arginylome

Author:
Seo, Taewook; Kim, Jihyo; Shin, Ho-Chul; Kim, Jung Gi; Ju, Shinyeong; Nawale, Laxman; Han, Goeun; Lee, Hye Seon; Bang, Geul; Kim, Jin Young; Bang, Jeong Kyu; Lee, Kyung Ho; Soung, Nak-Kyun; Hwang, Joonsung; Lee, Cheolju; Kim, Seung Jun; Kim, Bo Yeon; Cha-Molstad, Hyunjoo
Source:
Cellular and molecular life sciences 2021 v.78 no.7 pp. 3725-3741
ISSN:
1420-682X
Subject:
biomarkers,   etc   ; amyotrophic lateral sclerosis; cell senescence;     Show all 3 Subjects
Abstract:
... Protein arginylation is a critical regulator of a variety of biological processes. The ability to uncover the global arginylation pattern and its associated signaling pathways would enable us to identify novel disease targets. Here, we report the development of a tool able to capture the N-terminal arginylome. This tool, termed R-catcher, is based on the ZZ domain of p62, which was previously show ...
DOI:
10.1007/s00018-021-03805-x

13. Ultrasensitive detection of programmed death-ligand 1 (PD-L1) in whole blood using dispersible electrodes

Author:
Moazzam, Parisa; Myekhlai, Munkhshur; Alinezhad, Ali; Alshawawreh, Fida’a A.; Bakthavathsalam, Padmavathy; Gonçales, Vinicius R; Tilley, Richard D.; Gooding, J. Justin
Source:
Chemical communications 2021 v.57 no.20 pp. 2559-2562
ISSN:
1364-548X
Subject:
biomarkers,   etc   ; blood; detection limit; electrochemistry; magnetism; prognosis;     Show all 6 Subjects
Abstract:
... The direct quantification of programmed death-ligand 1 (PD-L1) as a biomarker for cancer diagnosis, prognosis and treatment efficacy is an unmet clinical need. Herein, we demonstrate the first report of rapid, ultrasensitive and selective electrochemical detection of PD-L1 directly in undiluted whole blood using modified gold-coated magnetic nanoparticles as “dispersible electrodes” with an ultral ...
DOI:
10.1039/d0cc08068c

14. Development, validation and utilisation of dish-based dietary assessment tools: a scoping review

Author:
Shinozaki, Nana; Yuan, Xiaoyi; Murakami, Kentaro; Sasaki, Satoshi
Source:
Public health nutrition 2021 v.24 no.2 pp. 223-242
ISSN:
1475-2727
Subject:
biomarkers,   etc   ; energy; nutrition assessment; public health;     Show all 4 Subjects
Abstract:
... To summarise the existing evidence of development, validation and current status of utilisation of dish-based dietary assessment tools. Scoping review. Systematic search using PubMed and Web of Science. We identified twelve tools from seventy-four eligible publications. They were developed for Koreans (n 4), Bangladeshis (n 2), Iranians (n 1), Indians/Malays/Chinese (n 1), Japanese (n 3) and Chine ...
DOI:
10.1017/S136898002000172X

15. Upconversion Luminescence-Controlled DNA Computation for Spatiotemporally Resolved, Multiplexed Molecular Imaging

Author:
Mi, Yongsheng; Zhao, Jian; Chu, Hongqian; Li, Zhixiang; Yu, Mingming; Li, Lele
Source:
Analytical chemistry 2021 v.93 no.4 pp. 2500-2509
ISSN:
1520-6882
Subject:
biomarkers,   etc   ; DNA; analytical chemistry; oligonucleotides; photons;     Show all 5 Subjects
Abstract:
... DNA-based molecular circuits able to perform complex information processing in biological systems are highly desirable. However, conventional DNA circuits are constitutively always in an ON state and immediately operate when they meet the biomolecular inputs, precluding precise molecular computation at a desired time and in a desired site. In this work, we report a conceptual methodology for the c ...
DOI:
10.1021/acs.analchem.0c04531

16. Molecular Identification of Tumor-Derived Extracellular Vesicles Using Thermophoresis-Mediated DNA Computation

Author:
Li, Yike; Deng, Jinqi; Han, Ziwei; Liu, Chao; Tian, Fei; Xu, Rui; Han, Da; Zhang, Shaohua; Sun, Jiashu
Source:
Journal of the American Chemical Society 2021 v.143 no.3 pp. 1290-1295
ISSN:
1520-5126
Subject:
biomarkers,   etc   ; DNA; biopsy; breast neoplasms; phenotype;     Show all 5 Subjects
Abstract:
... Molecular profiling of tumor-derived extracellular vesicles (tEVs) holds great promise for non-invasive cancer diagnosis. However, sensitive and accurate identification of tEVs is challenged by the heterogeneity of EV phenotypes which reflect different cell origins. Here we present a DNA computation device mediated by thermophoresis for detection of tEVs. The strategy leverages the aptamer-based l ...
DOI:
10.1021/jacs.0c12016

17. TCM network pharmacology: A new trend towards combining computational, experimental and clinical approaches

Author:
WANG, Xin; WANG, Zi-Yi; ZHENG, Jia-Hui; LI, Shao
Source:
Chinese journal of natural medicines 2021 v.19 no.1 pp. 1-11
ISSN:
1875-5364
Subject:
biomarkers,   etc   ; Oriental traditional medicine; biomedical research; pharmacology;     Show all 4 Subjects
Abstract:
... Traditional Chinese medicine (TCM) is a precious treasure of the Chinese nation and has unique advantages in the prevention and treatment of diseases. The holistic view of TCM coincides with the new generation of medical research paradigm characterized by network and system. TCM gave birth to a new method featuring holistic and systematic “network target”, a core theory and method of network pharm ...
DOI:
10.1016/S1875-5364(21)60001-8

18. Influence of Subclinical Ketosis in Dairy Cows on Ingestive-Related Behaviours Registered with a Real-Time System

Author:
Antanaitis, Ramūnas; Juozaitienė, Vida; Televičius, Mindaugas; Malašauskienė, Dovilė; Urbutis, Mingaudas; Baumgartner, Walter
Source:
Animals 2020 v.10 no.12
ISSN:
2076-2615
Subject:
biomarkers,   etc   ; ketosis; risk; rumination;     Show all 4 Subjects
Abstract:
... According to the literature, rumination time can be used as biomarker in the diagnosis of subclinical ketosis (SCK). We hypothesized that SCK in cows influences ingestive-related behaviours registered with the real-time system. The aim of the current study was to determine the influence of SCK on dairy cows’ ingestive-related behaviours registered with a real-time system. Twenty Lithuanian Black a ...
DOI:
10.3390/ani10122288

19. Aberrant alternative splicing of HTR2A exon II in peripheral blood lymphocytes of drug-naïve schizophrenic patients

Author:
Grunina, Maria N.; Belinskaia, Mariia A.; Zhuravlev, Alexander S.; Nasyrova, Regina F.; Krupitsky, Evgeny M.; Taraskina, Anastasiya E.; Zabotina, Anna M.
Source:
Heliyon 2020 v.6 no.12 pp. e05809
ISSN:
2405-8440
Subject:
biomarkers,   etc   ; exons; schizophrenia; therapeutics;     Show all 4 Subjects
Abstract:
... The aim of the study was to characterize the pattern of transcript isoforms of HTR2A exon II in lymphocytes of the blood as peripheral biomarkers of schizophrenia development and the effectiveness of antipsychotic therapy. We primarily observed an increase in mRNA levels and elevation of alternative variants in a sample of drug-naïve schizophrenic patients compared to the control group. There was ...
DOI:
10.1016/j.heliyon.2020.e05809

20. Relying on repeated biospecimens to reduce the effects of classical-type exposure measurement error in studies linking the exposome to health

Author:
Agier, Lydiane; Slama, Rémy; Basagaña, Xavier
Source:
Environmental research 2020 v.186 pp. 109492
ISSN:
0013-9351
Subject:
biomarkers,   etc   ; calibration; temporal variation;     Show all 3 Subjects
Abstract:
... The exposome calls for assessing numerous exposures, typically using biomarkers with varying amounts of measurement error, which can be assumed to be of classical type. We evaluated the impact of classical-type measurement error on the performance of exposome-health studies, and the efficiency of two measurement error correction methods relying on the collection of repeated biospecimens: within-su ...
DOI:
10.1016/j.envres.2020.109492