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... With the rapid development of intelligent technology, the smart heightened-containment biological laboratory (sHCBL) has moved from concept to reality. Experimental activities and laboratory construction, operation, and management will undoubtedly lead to disruptive changes. Conventional laboratories are increasingly being replaced by smart laboratories; however, the key technologies involved in t ...
biosafety, etc ; biosecurity; health services; product development; Show all 4 Subjects
Abstract:
... Biological threats, whether naturally occurring or accidentally or deliberately released, have the potential to endanger lives and disrupt economies worldwide. Thus, high-containment protective measures should be implemented when handling bio-agents that can cause serious, highly contagious diseases, otherwise devastating pandemics can occur. In the fields of scientific investigation, healthcare, ...
biosafety, etc ; chemistry; face; iron oxides; magnetism; nickel; Show all 6 Subjects
Abstract:
... Small-sized iron oxide nanoparticles (IONPs) are an excellent alternative to clinical gadolinium-based contrast agents (GBCAs) in T₁-weighted magnetic resonance imaging (MRI) due to their biosafety. However, their relaxation efficiency and contrast enhancement are not significant compared with those of GBCAs, and the nanomaterials face stability problems in vivo and difficulties in large-scale syn ...
biosafety, etc ; DNA; DNA fragmentation; biotechnology; crops; transgenes; Show all 6 Subjects
Abstract:
... Molecular characterization of genetically modified organisms (GMOs) yields basic information on exogenous DNA integration, including integration sites, entire inserted sequences and structures, flanking sequences and copy number, providing key data for biosafety assessment. However, there are few effective methods for deciphering transgene integration, especially for large DNA fragment integration ...
biosafety, etc ; biosecurity; certification; medicine; microbiology; public health; Egypt; Show all 7 Subjects
Abstract:
... Microbiology Research Laboratory (MRL) is a biosafety level-2 (BSL-2) research laboratory located at the main campus of Faculty of Medicine, Ain Shams University (ASU) in Cairo. With the objective of strengthening the departmental capacities of biosafety, a series of activities were carried out between October 2019, and January 2020 to raise awareness, along with instilling standard biosafety prac ...
biosafety, etc ; corn; food composition; quantitative polymerase chain reaction; standard deviation; China; Show all 6 Subjects
Abstract:
... The genetically modified (GM) maize DBN9936 that has been granted a biosafety certificate needs to be regulated in China. An event-specific PCR assay targeting the junction region between the left border of its T-DNA and the flanking genomic DNA (gDNA) was established to be able to specifically identify the DBN9936 event from other GM maize and non-GM maize. Both qPCR and duplex ddPCR achieved acc ...
biosafety, etc ; analgesia; analgesics; anesthetics; biocompatible materials; hydrogels; lidocaine; models; pain; transdermal application; Show all 10 Subjects
Abstract:
... Considering the staggering global prevalence of local pain affecting hundreds of million individuals, it is of great significance to develop advanced dosage forms or delivery systems for analgesic therapy to fulfill clinical applicability. In this study, a hydrogel microneedles (MNs) system made out of gelatin-methacryloyl (GelMA) was designed to deliver lidocaine hydrochloride (LiH) in a sustaine ...
biosafety, etc ; biofilm; methicillin-resistant Staphylococcus aureus; mortality; peroxidase; superoxide anion; therapeutics; toxicity; Show all 8 Subjects
Abstract:
... A rapid increase in methicillin-resistant Staphylococcus aureus (MRSA) induced infection has been noticed in recent years and the biofilm formed by MRSA further delays wound healing, causing a high mortality rate. Hence, a safe and effective superoxide radical (O₂•–) mediated self-synthesis strategy is developed to prepare Au-doped MoO₃–ₓ (Au/MoO₃–ₓ) plasmonic-semiconductor hybrid for the eliminat ...
biosafety, etc ; cold storage; genetic improvement; lipid peroxidation; liquids; metabolism; rams; semen; sperm quality; Show all 9 Subjects
Abstract:
... Semen preservation is an essential component of reproductive technologies, as it promotes genetic gain and long-distance semen transport and multiplies the number of ewes able to be inseminated per single ejaculate. However, the reduced temperature during cold storage at 5 or 15 °C inflicts sub-lethal damage to spermatozoa, compromising sperm quality and the success of artificial breeding. New and ...
biosafety, etc ; Influenza A virus; RNA; aerosols; avian influenza; guanidines; methanol; mortality; risk; viruses; Show all 10 Subjects
Abstract:
... The objective of this study was to determine the inactivation efficiency of common sample preparation reagents against highly pathogenic avian influenza A (HPAI) H5N1 virus. HPAI H5N1 virus has caused infections in humans with a mortality rate of over 50%. Due to the high mortality and the risk of aerosol transmission of that virus to humans and birds, infectious HPAI H5N1 viruses are contained in ...
biosafety, etc ; biomimetics; blood; blood circulation; chemical bonding; dialysis; drugs; hepatoma; ligands; macrophages; nanocarriers; Show all 11 Subjects
Abstract:
... Successful hepatocellular carcinoma (HCC) therapy in vivo remains a significant challenge due to the down-regulated expression of the receptors on the surface of tumor cells for compromised active targeting efficiency and cellular uptake of nanoparticles (NPs)-based drug delivery systems (DDSs) and “accelerated blood clearance” and premature unpackaging of NPs in vivo induced by the poly(ethylene ...
biosafety, etc ; butanol; liquid-liquid extraction; peaches; saprophytes; sodium; sodium alginate; sterols; triterpenoid saponins; Show all 9 Subjects
Abstract:
... The extract from Anemone vitifolia Buch.-Ham. was used for postharvest peach preservation for the first time. Different extracts of A. vitifolia were obtained by liquid-liquid extraction based on the gradient polarity, which were analyzed and characterized through HPLC, TLC NMR data and related literatures. Seven saprophytic fungi were isolated and identified from rotting peaches, thus clarifying ...
biosafety, etc ; COVID-19 infection; biodegradation; disinfection; durability; filtration; industry; municipal solid waste; pollution; polypropylenes; Show all 10 Subjects
Abstract:
... The coronavirus disease 2019 (COVID-19) has swept the world and still afflicts humans. As an effective means of protection, wearing masks has been widely adopted by the general public. The massive use of disposable masks has raised some emerging environmental and bio-safety concerns: improper handling of used masks may transfer the attached pathogens to environmental media; disposable masks mainly ...
biosafety, etc ; X-radiation; biomimetics; blood; breast neoplasms; cancer therapy; enzymes; hydroxyl radicals; radiotherapy; toxicity; Show all 10 Subjects
Abstract:
... Radiotherapy has been widely applied for breast cancer treatment in the clinic, while improving the radiation sensitivity of tumors and protecting normal tissues from radiation damage has drawn considerable attention. In this study, we reported a biomimetic multifunctional nanozyme (BSA@CeO/Fe²⁺), which can be used as a radiosensitizer for breast cancer treatment. It was demonstrated that BSA@CeO/ ...
biosafety, etc ; biomass; bisphenol A; cross-linking reagents; epoxides; fossils; lignosulfonates; raw materials; shear strength; Show all 9 Subjects
Abstract:
... The gradually depleting fossil resources and the biosafety of bisphenol A have always restricted the green development of the traditional epoxy resin field. In this Article, biomass macromolecule lignin sulfonates are selected as the raw material instead of traditional bisphenol A to prepare lignin-based epoxy resin adhesives. Lignin sulfonates are chemically modified and combined with a cross-lin ...
biosafety, etc ; COVID-19 infection; automatic detection; biosecurity; disease diagnosis; disease prevention; equipment; nucleic acids; Show all 8 Subjects
Abstract:
... Nucleic acid detection, widely used in clinical diagnosis, biological analysis, and environmental monitoring, is of great significance for disease diagnosis and basic research. With the outbreak of COVID-19, the demand for fast and high-throughput nucleic acid detection from large numbers of samples has increased sharply. Automated nucleic acid detection systems can meet these needs, and also play ...
biosafety, etc ; COVID-19 infection; air flow; bioaerosols; cross infection; pollution; probability; research; simulation models; Show all 9 Subjects
Abstract:
... The outbreak of COVID-19 has caused increasing public attention to laboratory-acquired infections (LAIs), especially for a mobile Bio-Safety Level 4 Lab (BSL-4) with high potential of exposure. In this paper, the distribution and removal mechanism of bioaerosols in the biosafety laboratory were studied. A simulation model of airflow distribution in the opening and closing state of air-tight door w ...
biosafety, etc ; antioxidants; cancer therapy; endocytosis; hyaluronic acid; hydrophobic bonding; isothiocyanates; neoplasms; oxidation; oxidative stress; permeability; Show all 11 Subjects
Abstract:
... Tumor cells with innate oxidative stress are more susceptible to exogenous ROS-mediated oxidative damage than normal cells. However, the generated ROS could be scavenged by the overexpressed GSH in cancer cells, thus causing greatly restricted efficiency of ROS-mediated antitumor therapy. Herein, using cinnamaldehyde (CA) as a ROS generator while β-phenethyl isothiocyanate (PEITC) as a GSH scaveng ...
biosafety, etc ; biocompatibility; cancer therapy; computed tomography; drugs; glucose; health services; immunotherapy; magnetism; nanocomposites; nanomedicine; photochemotherapy; radiotherapy; Show all 13 Subjects
Abstract:
... The rapid development and wide application of nanomaterial-involved theranostic agents have drawn surging attention for improving the living standard of humankind and healthcare conditions. In this review, recent developments in the design, synthesis, biocompatibility evaluation and potential nanomedicine applications of FePt-involved nano-systems are summarized, especially for cancer theranostic ...
biosafety, etc ; COVID-19 infection; biosecurity; dynamic models; immunity; issues and policy; model validation; prediction; quarantine; China; Show all 10 Subjects
Abstract:
... It’s urgently needed to assess the COVID-19 epidemic under the “dynamic zero-COVID policy” in China, which provides a scientific basis for evaluating the effectiveness of this strategy in COVID-19 control. Here, we developed a time-dependent susceptible-exposed-asymptomatic-infected-quarantined-removed (SEAIQR) model with stage-specific interventions based on recent Shanghai epidemic data, conside ...