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1. Smart heightened-containment biological laboratory: technologies, modules, and aims

Author:
Jiaming Li; Zhongyi Wang; Gang Tao; Yingying Fu; Yifei Jin; Hongliang Cheng; Jingjing Li; Xinrong Shu; Jianjian Yang; Jiuxiang Yang; Bing Lu
Source:
Journal of biosafety and biosecurity 2022 pp. -
ISSN:
2588-9338
Subject:
biosafety,   etc   ; automation; biosecurity;     Show all 3 Subjects
Abstract:
... With the rapid development of intelligent technology, the smart heightened-containment biological laboratory (sHCBL) has moved from concept to reality. Experimental activities and laboratory construction, operation, and management will undoubtedly lead to disruptive changes. Conventional laboratories are increasingly being replaced by smart laboratories; however, the key technologies involved in t ...
DOI:
10.1016/j.jobb.2022.06.003

2. High-containment facilities and the role they play in global health security

Author:
Han Xia; Zhiming Yuan
Source:
Journal of biosafety and biosecurity 2022 v.4 no.1 pp. 1-4
ISSN:
2588-9338
Subject:
biosafety,   etc   ; biosecurity; health services; product development;     Show all 4 Subjects
Abstract:
... Biological threats, whether naturally occurring or accidentally or deliberately released, have the potential to endanger lives and disrupt economies worldwide. Thus, high-containment protective measures should be implemented when handling bio-agents that can cause serious, highly contagious diseases, otherwise devastating pandemics can occur. In the fields of scientific investigation, healthcare, ...
DOI:
10.1016/j.jobb.2021.11.005

3. Facile synthesis of superparamagnetic nickel-doped iron oxide nanoparticles as high-performance T₁ contrast agents for magnetic resonance imaging

Author:
Chichong Lu; Xue Xu; Tingting Zhang; Zhijie Wang; Yuyun Chai
Source:
Journal of materials chemistry B 2022 v.10 no.10 pp. 1623-1633
ISSN:
2050-7518
Subject:
biosafety,   etc   ; chemistry; face; iron oxides; magnetism; nickel;     Show all 6 Subjects
Abstract:
... Small-sized iron oxide nanoparticles (IONPs) are an excellent alternative to clinical gadolinium-based contrast agents (GBCAs) in T₁-weighted magnetic resonance imaging (MRI) due to their biosafety. However, their relaxation efficiency and contrast enhancement are not significant compared with those of GBCAs, and the nanomaterials face stability problems in vivo and difficulties in large-scale syn ...
DOI:
10.1039/d1tb02572d

4. LIFE‐Seq: a universal Large Integrated DNA Fragment Enrichment Sequencing strategy for deciphering the transgene integration of genetically modified organisms

Author:
Hanwen Zhang; Rong Li; Yongkun Guo; Yuchen Zhang; Dabing Zhang; Litao Yang
Source:
Plant biotechnology journal 2022 v.20 no.5 pp. 964-976
ISSN:
1467-7644
Subject:
biosafety,   etc   ; DNA; DNA fragmentation; biotechnology; crops; transgenes;     Show all 6 Subjects
Abstract:
... Molecular characterization of genetically modified organisms (GMOs) yields basic information on exogenous DNA integration, including integration sites, entire inserted sequences and structures, flanking sequences and copy number, providing key data for biosafety assessment. However, there are few effective methods for deciphering transgene integration, especially for large DNA fragment integration ...
DOI:
10.1111/pbi.13776

5. Tier-based approach to establish a culture of biosafety at a medical microbiology research laboratory in Egypt

Author:
Mona El-Shokry; Nesma Hamdi; Shimaa Abdel Salam; Nagwa M. Abo El Magd
Source:
Journal of biosafety and biosecurity 2022 v.4 no.1 pp. 17-22
ISSN:
2588-9338
Subject:
biosafety,   etc   ; biosecurity; certification; medicine; microbiology; public health; Egypt;     Show all 7 Subjects
Abstract:
... Microbiology Research Laboratory (MRL) is a biosafety level-2 (BSL-2) research laboratory located at the main campus of Faculty of Medicine, Ain Shams University (ASU) in Cairo. With the objective of strengthening the departmental capacities of biosafety, a series of activities were carried out between October 2019, and January 2020 to raise awareness, along with instilling standard biosafety prac ...
DOI:
10.1016/j.jobb.2021.09.004

6. Event-specific PCR methods to quantify the genetically modified DBN9936 maize

Author:
Jun Li; Hongfei Gao; Yunjing Li; Fang Xiao; Shanshan Zhai; Gang Wu; Yuhua Wu
Source:
Journal of food composition and analysis 2022 v.105 pp. 104236
ISSN:
0889-1575
Subject:
biosafety,   etc   ; corn; food composition; quantitative polymerase chain reaction; standard deviation; China;     Show all 6 Subjects
Abstract:
... The genetically modified (GM) maize DBN9936 that has been granted a biosafety certificate needs to be regulated in China. An event-specific PCR assay targeting the junction region between the left border of its T-DNA and the flanking genomic DNA (gDNA) was established to be able to specifically identify the DBN9936 event from other GM maize and non-GM maize. Both qPCR and duplex ddPCR achieved acc ...
DOI:
10.1016/j.jfca.2021.104236

7. A high-dosage microneedle for programmable lidocaine delivery and enhanced local long-lasting analgesia

Author:
Ze Qiang Zhao; Bao Li Zhang; Hua Qing Chu; Ling Liang; Bo Zhi Chen; Hui Zheng; Xin Dong Guo
Source:
Biomaterials advances 2022 v.133 pp. 112620
ISSN:
2772-9508
Subject:
biosafety,   etc   ; analgesia; analgesics; anesthetics; biocompatible materials; hydrogels; lidocaine; models; pain; transdermal application;     Show all 10 Subjects
Abstract:
... Considering the staggering global prevalence of local pain affecting hundreds of million individuals, it is of great significance to develop advanced dosage forms or delivery systems for analgesic therapy to fulfill clinical applicability. In this study, a hydrogel microneedles (MNs) system made out of gelatin-methacryloyl (GelMA) was designed to deliver lidocaine hydrochloride (LiH) in a sustaine ...
DOI:
10.1016/j.msec.2021.112620

8. Superoxide Radical-Mediated Self-Synthesized Au/MoO₃–ₓ Hybrids with Enhanced Peroxidase-like Activity and Photothermal Effect for Anti-MRSA Therapy

Author:
Mengyu Cao; Zhishang Chang; Jinshan Tan; Xiaoning Wang; Pengfei Zhang; Sen Lin; Jingquan Liu; Aihua Li
Source:
ACS applied materials & interfaces 2022 v.14 no.11 pp. 13025-13037
ISSN:
1944-8252
Subject:
biosafety,   etc   ; biofilm; methicillin-resistant Staphylococcus aureus; mortality; peroxidase; superoxide anion; therapeutics; toxicity;     Show all 8 Subjects
Abstract:
... A rapid increase in methicillin-resistant Staphylococcus aureus (MRSA) induced infection has been noticed in recent years and the biofilm formed by MRSA further delays wound healing, causing a high mortality rate. Hence, a safe and effective superoxide radical (O₂•–) mediated self-synthesis strategy is developed to prepare Au-doped MoO₃–ₓ (Au/MoO₃–ₓ) plasmonic-semiconductor hybrid for the eliminat ...
DOI:
10.1021/acsami.1c23676

9. Factors Affecting the Survival of Ram Spermatozoa during Liquid Storage and Options for Improvement

Author:
Natalie Rizkallah; Caitlin G. Chambers; Simon P. de Graaf; Jessica P. Rickard
Source:
Animals 2022 v.12 no.3 pp. -
ISSN:
2076-2615
Subject:
biosafety,   etc   ; cold storage; genetic improvement; lipid peroxidation; liquids; metabolism; rams; semen; sperm quality;     Show all 9 Subjects
Abstract:
... Semen preservation is an essential component of reproductive technologies, as it promotes genetic gain and long-distance semen transport and multiplies the number of ewes able to be inseminated per single ejaculate. However, the reduced temperature during cold storage at 5 or 15 °C inflicts sub-lethal damage to spermatozoa, compromising sperm quality and the success of artificial breeding. New and ...
DOI:
10.3390/ani12030244

10. Inactivation efficacy of H5N1 avian influenza virus by commonly used sample preparation reagents for safe laboratory practices

Author:
Veera Avelin; Susanna Sissonen; Ilkka Julkunen; Pamela Österlund
Source:
Journal of virological methods 2022 v.304 pp. 114527
ISSN:
0166-0934
Subject:
biosafety,   etc   ; Influenza A virus; RNA; aerosols; avian influenza; guanidines; methanol; mortality; risk; viruses;     Show all 10 Subjects
Abstract:
... The objective of this study was to determine the inactivation efficiency of common sample preparation reagents against highly pathogenic avian influenza A (HPAI) H5N1 virus. HPAI H5N1 virus has caused infections in humans with a mortality rate of over 50%. Due to the high mortality and the risk of aerosol transmission of that virus to humans and birds, infectious HPAI H5N1 viruses are contained in ...
DOI:
10.1016/j.jviromet.2022.114527

11. Prolonged blood circulation outperforms active targeting for nanocarriers-mediated enhanced hepatocellular carcinoma therapy in vivo

Author:
Yue-Qing Wang; Cong Huang; Peng-Ju Ye; Jin-Rong Long; Cheng-Hu Xu; Ying Liu; Xiao-Li Ling; Shao-Yang Lv; Dong-Xiu He; Hua Wei; Cui-Yun Yu
Source:
Journal of controlled release 2022 v.347 pp. 400-413
ISSN:
0168-3659
Subject:
biosafety,   etc   ; biomimetics; blood; blood circulation; chemical bonding; dialysis; drugs; hepatoma; ligands; macrophages; nanocarriers;     Show all 11 Subjects
Abstract:
... Successful hepatocellular carcinoma (HCC) therapy in vivo remains a significant challenge due to the down-regulated expression of the receptors on the surface of tumor cells for compromised active targeting efficiency and cellular uptake of nanoparticles (NPs)-based drug delivery systems (DDSs) and “accelerated blood clearance” and premature unpackaging of NPs in vivo induced by the poly(ethylene ...
DOI:
10.1016/j.jconrel.2022.05.024

12. Sodium alginate-based coating incorporated with Anemone vitifolia Buch.-Ham. extract: Application in peach preservation

Author:
Linyun Mou; Ya Lu; Yunguan Xi; Ganpeng Li; Jianlong Li
Source:
Industrial crops and products 2022 v.176 pp. 114329
ISSN:
0926-6690
Subject:
biosafety,   etc   ; butanol; liquid-liquid extraction; peaches; saprophytes; sodium; sodium alginate; sterols; triterpenoid saponins;     Show all 9 Subjects
Abstract:
... The extract from Anemone vitifolia Buch.-Ham. was used for postharvest peach preservation for the first time. Different extracts of A. vitifolia were obtained by liquid-liquid extraction based on the gradient polarity, which were analyzed and characterized through HPLC, TLC NMR data and related literatures. Seven saprophytic fungi were isolated and identified from rotting peaches, thus clarifying ...
DOI:
10.1016/j.indcrop.2021.114329

13. A pandemic-induced environmental dilemma of disposable masks: solutions from the perspective of the life cycle

Author:
Zigu Chen; Weican Zhang; Hang Yang; Ke Min; Jie Jiang; Dawei Lu; Xiu Huang; Guangbo Qu; Qian Liu; Guibin Jiang
Source:
Environmental science 2022 v.24 no.5 pp. 649-674
ISSN:
2050-7895
Subject:
biosafety,   etc   ; COVID-19 infection; biodegradation; disinfection; durability; filtration; industry; municipal solid waste; pollution; polypropylenes;     Show all 10 Subjects
Abstract:
... The coronavirus disease 2019 (COVID-19) has swept the world and still afflicts humans. As an effective means of protection, wearing masks has been widely adopted by the general public. The massive use of disposable masks has raised some emerging environmental and bio-safety concerns: improper handling of used masks may transfer the attached pathogens to environmental media; disposable masks mainly ...
DOI:
10.1039/d1em00509j

14. Biomimetic multifunctional nanozymes enhanced radiosensitization for breast cancer via an X-ray triggered cascade reaction

Author:
Lin Yang; Xiao Du; Yanru Qin; Xueyuan Wang; Liefeng Zhang; Zhimeng Chen; Zhongjie Wang; Xu Yang; Meng Lei; Yongqiang Zhu
Source:
Journal of materials chemistry B 2022 v.10 no.19 pp. 3667-3680
ISSN:
2050-7518
Subject:
biosafety,   etc   ; X-radiation; biomimetics; blood; breast neoplasms; cancer therapy; enzymes; hydroxyl radicals; radiotherapy; toxicity;     Show all 10 Subjects
Abstract:
... Radiotherapy has been widely applied for breast cancer treatment in the clinic, while improving the radiation sensitivity of tumors and protecting normal tissues from radiation damage has drawn considerable attention. In this study, we reported a biomimetic multifunctional nanozyme (BSA@CeO/Fe²⁺), which can be used as a radiosensitizer for breast cancer treatment. It was demonstrated that BSA@CeO/ ...
DOI:
10.1039/d2tb00184e

15. Double-Interpenetrating-Network Lignin-based Epoxy Resin Adhesives for Resistance to Extreme Environment

Author:
Weishi Wang; Yao Li; Heying Zhang; Ting Chen; Guangwei Sun; Ying Han; Jigeng Li
Source:
Biomacromolecules 2022 v.23 no.3 pp. 779-788
ISSN:
1526-4602
Subject:
biosafety,   etc   ; biomass; bisphenol A; cross-linking reagents; epoxides; fossils; lignosulfonates; raw materials; shear strength;     Show all 9 Subjects
Abstract:
... The gradually depleting fossil resources and the biosafety of bisphenol A have always restricted the green development of the traditional epoxy resin field. In this Article, biomass macromolecule lignin sulfonates are selected as the raw material instead of traditional bisphenol A to prepare lignin-based epoxy resin adhesives. Lignin sulfonates are chemically modified and combined with a cross-lin ...
DOI:
10.1021/acs.biomac.1c01204

16. Recent developments and trends of automatic nucleic acid detection systems

Author:
Xujun Yuan; Guodong Sui; Dawei Zhang; Min Chen; Wang Zhao
Source:
Journal of biosafety and biosecurity 2022 v.4 no.1 pp. 54-58
ISSN:
2588-9338
Subject:
biosafety,   etc   ; COVID-19 infection; automatic detection; biosecurity; disease diagnosis; disease prevention; equipment; nucleic acids;     Show all 8 Subjects
Abstract:
... Nucleic acid detection, widely used in clinical diagnosis, biological analysis, and environmental monitoring, is of great significance for disease diagnosis and basic research. With the outbreak of COVID-19, the demand for fast and high-throughput nucleic acid detection from large numbers of samples has increased sharply. Automated nucleic acid detection systems can meet these needs, and also play ...
DOI:
10.1016/j.jobb.2022.02.001

17. Study on contaminant distribution in a mobile BSL-4 laboratory based on multi-region directional airflow

Author:
Yan Wang; Jian-Tao Miao; Jian-Bo Chen; Hua-Yi Chai; Chun-Yu Zhu; Hong-An Tang; Yi Gan
Source:
Environmental science and pollution research 2022 v.29 no.8 pp. 12100-12114
ISSN:
0944-1344
Subject:
biosafety,   etc   ; COVID-19 infection; air flow; bioaerosols; cross infection; pollution; probability; research; simulation models;     Show all 9 Subjects
Abstract:
... The outbreak of COVID-19 has caused increasing public attention to laboratory-acquired infections (LAIs), especially for a mobile Bio-Safety Level 4 Lab (BSL-4) with high potential of exposure. In this paper, the distribution and removal mechanism of bioaerosols in the biosafety laboratory were studied. A simulation model of airflow distribution in the opening and closing state of air-tight door w ...
DOI:
10.1007/s11356-021-16394-w

18. Tumor-targeted hyaluronic acid-based oxidative stress nanoamplifier with ROS generation and GSH depletion for antitumor therapy

Author:
Qiuxing Liu; Xin Ding; Xiaoyu Xu; Hualu Lai; Zishan Zeng; Ting Shan; Tao Zhang; Meixu Chen; Yanjuan Huang; Zeqian Huang; Xiuling Dai; Meng Xia; Shengmiao Cui
Source:
International journal of biological macromolecules 2022 v.207 pp. 771-783
ISSN:
0141-8130
Subject:
biosafety,   etc   ; antioxidants; cancer therapy; endocytosis; hyaluronic acid; hydrophobic bonding; isothiocyanates; neoplasms; oxidation; oxidative stress; permeability;     Show all 11 Subjects
Abstract:
... Tumor cells with innate oxidative stress are more susceptible to exogenous ROS-mediated oxidative damage than normal cells. However, the generated ROS could be scavenged by the overexpressed GSH in cancer cells, thus causing greatly restricted efficiency of ROS-mediated antitumor therapy. Herein, using cinnamaldehyde (CA) as a ROS generator while β-phenethyl isothiocyanate (PEITC) as a GSH scaveng ...
DOI:
10.1016/j.ijbiomac.2022.03.139

19. Advances in FePt-involved nano-system design and application for bioeffect and biosafety

Author:
Zunfu Hu; Qiulian Wei; Huimin Zhang; Weina Tang; Yunkai Kou; Yunqiang Sun; Zhichao Dai; Xiuwen Zheng
Source:
Journal of materials chemistry B 2022 v.10 no.3 pp. 339-357
ISSN:
2050-7518
Subject:
biosafety,   etc   ; biocompatibility; cancer therapy; computed tomography; drugs; glucose; health services; immunotherapy; magnetism; nanocomposites; nanomedicine; photochemotherapy; radiotherapy;     Show all 13 Subjects
Abstract:
... The rapid development and wide application of nanomaterial-involved theranostic agents have drawn surging attention for improving the living standard of humankind and healthcare conditions. In this review, recent developments in the design, synthesis, biocompatibility evaluation and potential nanomedicine applications of FePt-involved nano-systems are summarized, especially for cancer theranostic ...
DOI:
10.1039/d1tb02221k

20. Coronavirus disease 2019 epidemic prediction in Shanghai under the “dynamic zero-COVID policy” using time-dependent SEAIQR model

Author:
Ma Yifei; Xu Shujun; An Qi; Qin Mengxia; Li Sitian; Lu Kangkang; Li Jiantao; Lei Lijian; He Lu; Yu Hongmei; Xie Jun
Source:
Journal of biosafety and biosecurity 2022 pp. -
ISSN:
2588-9338
Subject:
biosafety,   etc   ; COVID-19 infection; biosecurity; dynamic models; immunity; issues and policy; model validation; prediction; quarantine; China;     Show all 10 Subjects
Abstract:
... It’s urgently needed to assess the COVID-19 epidemic under the “dynamic zero-COVID policy” in China, which provides a scientific basis for evaluating the effectiveness of this strategy in COVID-19 control. Here, we developed a time-dependent susceptible-exposed-asymptomatic-infected-quarantined-removed (SEAIQR) model with stage-specific interventions based on recent Shanghai epidemic data, conside ...
DOI:
10.1016/j.jobb.2022.06.002