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1. Correction to: Re-evaluation of biosafety questions on genetically modified biocontrol bacteria

Author:
Glandorf, Debora C. M.
Source:
European journal of plant pathology 2019 v.154 no.1 pp. 53
ISSN:
0929-1873
Subject:
biosafety,   etc   ; bacteria; biological control;     Show all 3 Subjects
Abstract:
... The original article has been corrected, as author wanted to cancel Open Access ...
DOI:
10.1007/s10658-018-01619-5

2. Biosafety and biosecurity in Synthetic Biology: A review

Author:
Gómez-Tatay, Lucía; Hernández-Andreu, José M.
Source:
Critical reviews in environmental science and technology 2019 v.49 no.17 pp. 1587-1621
ISSN:
1547-6537
Subject:
biosafety,   etc   ; biosecurity; bioterrorism; genetic engineering; human health; risk; synthetic biology;     Show all 7 Subjects
Abstract:
... Synthetic Biology is a growing field which holds great promise in several areas of application. However, it also poses serious risks for human health and the environment that must be anticipated in order to develop effective prevention and management measures. Here, the current situation on biosafety and biosecurity in this scientific field is reviewed. Biosafety concerns mainly relate to the dama ...
DOI:
10.1080/10643389.2019.1579628

3. Role of protein corona in the biological effect of nanomaterials: Investigating methods

Author:
Zeng, Li; Gao, Jiejun; Liu, Yanna; Gao, Jie; Yao, Linlin; Yang, Xiaoxi; Liu, Xiaolei; He, Bin; Hu, Ligang; Shi, Jianbo; Song, Maoyong; Qu, Guangbo; Jiang, Guibin
Source:
Trends in analytical chemistry 2019 v.118 pp. 303-314
ISSN:
0165-9936
Subject:
biosafety,   etc   ; bioactive properties; human health; nanoparticles; particulates; protein corona;     Show all 6 Subjects
Abstract:
... Growing developments in engineered nanomaterials (NMs) and their wide applications inevitably raise environmental and human health concerns. Upon contact with biological fluids, NMs can attract proteins onto their surfaces to form dynamic layers called protein corona. Such new biological identities are what the bio-systems “see” and react with. Formation of protein corona around NMs determines the ...
DOI:
10.1016/j.trac.2019.05.039

4. A 3D-printed portable device for field deployment of living biosensors

Author:
Movizzo, Paul G.; Ruder, Warren C.; Long, Zhicheng
Source:
MethodsX 2019 v.6 pp. 1331-1335
ISSN:
2215-0161
Subject:
biosafety,   etc   ; biomarkers; biosensors; genetically modified organisms; portable equipment; risk;     Show all 6 Subjects
Abstract:
... Living biosensors typically use genetically modified organisms (GMOs) to detect infectious biomarkers in clinical samples. GMOs are prohibited to be released into the environment by many laws, which limits the application of living biosensors outside laboratory settings. Here, we reported a robust 3D-printed device that eliminates the risk of exposure of GMOs to potential users and the environment ...
DOI:
10.1016/j.mex.2019.05.018

5. Synthetic symbiosis combining plasmid displacement enables rapid construction of phenotype-stable strains

Author:
Zhang, Ruihua; Yang, Yaping; Wang, Jian; Lin, Yuheng; Yan, Yajun
Source:
Metabolic engineering 2019 v.55 pp. 85-91
ISSN:
1096-7176
Subject:
biosafety,   etc   ; Escherichia coli; antibiotics; engineering; genes; inheritance (genetics); phenotype; plasmids; salicylic acid; symbiosis;     Show all 10 Subjects
Abstract:
... Plasmid-based microbial systems have been a major workhorse for chemical and pharmaceutical production. The biosafety issues and elevated industrial cost of antibiotic usage have led to the development of alternative strategies for plasmid selection and maintenance. Such strategies, including auxotrophy complementation, post-segregational killing, operator-repressor and RNA-based interactions ofte ...
DOI:
10.1016/j.ymben.2019.06.011

6. Licorice flavonoids nanoparticles prepared by liquid antisolvent re-crystallization exhibit higher oral bioavailability and antioxidant activity in rat

Author:
Wang, Zijian; Zhao, Xiuhua; Zu, Yuangang; Wu, Weiwei; Li, Yuanyuan; Guo, Zijing; Wang, Li; Wang, Lingling
Source:
Journal of functional foods 2019 v.57 pp. 190-201
ISSN:
1756-4646
Subject:
biosafety,   etc   ; antioxidant activity; bioavailability; flavonoids; gastric juice; health services; licorice; liquids; nanoparticles; rats; solubility;     Show all 11 Subjects
Abstract:
... The aim of the experiment was to prepare licorice flavonoids nanoparticles (LFNs) by a liquid antisolvent re-crystallization (LAR) method to improve its oral bioavailability. The experimental data suggested that the saturation solubility of LFNs was 25 times of raw licorice flavonoids (LFs), and at 720 min, the dissolution rates of LFNs in artificial intestinal juice and artificial gastric juice w ...
DOI:
10.1016/j.jff.2019.04.010

7. Integrated Hydrogel Platform for Programmed Antitumor Therapy Based on Near Infrared-Triggered Hyperthermia and Vascular Disruption

Author:
Liang, Yuqing; Hao, Yijun; Wu, Yingjiao; Zhou, Zhijun; Li, Juan; Sun, Xiaoyi; Liu, You-Nian
Source:
ACS applied materials & interfaces 2019 v.11 no.24 pp. 21381-21390
ISSN:
1944-8252
Subject:
biosafety,   etc   ; cutting; energy; fever; hydrogels; irradiation; nanocomposites; nanoparticles; near-infrared spectroscopy; neoplasm cells; neoplasms; remission; therapeutics;     Show all 13 Subjects
Abstract:
... Complete tumor regression is a great challenge faced by single therapy of near-infrared (NIR)-triggered hyperthermia or vascular disrupting agents. An injectable nanocomposite (NC) hydrogel is rationally designed for combined anticancer therapy based on NIR-triggered hyperthermia and vascular disruption. The NC hydrogel, codelivered with Prussian blue (PB) nanoparticles and combretastatin A4 (CA4) ...
DOI:
10.1021/acsami.9b05536

8. pH-sensitive loaded retinal/indocyanine green micelles as an “all-in-one” theranostic agent for multi-modal imaging in vivo guided cellular senescence-photothermal synergistic therapy

Author:
ZhuThese authors contributed equally to this work., Lipeng; Li, Ping; Gao, Duyang; Liu, Jie; Liu, Yubin; Sun, Chen; Xu, Mengze; Chen, Xin; Sheng, Zonghai; Wang, Ruibing; Yuan, Zhen; Cai, Lintao; Ma, Yifan; Zhao, Qi
Source:
Chemical communications 2019 v.55 no.44 pp. 6209-6212
ISSN:
1364-548X
Subject:
biosafety,   etc   ; antineoplastic activity; chemical compounds; chemical reactions; image analysis; micelles; neoplasms; therapeutics;     Show all 8 Subjects
Abstract:
... In this study, pH-sensitive loaded retinal/indocyanine green (ICG) micelles were developed to realize novel approaches for cellular senescence-photothermal synergistic therapy to treat cancer. The micelles could enable effective multi-modal imaging in vivo guided therapy and show anticancer activity in vitro and in vivo with satisfactory biosafety. ...
DOI:
10.1039/c9cc02567g

9. Self-Strengthened Oxidation-Responsive Bioactivating Prodrug Nanosystem with Sequential and Synergistically Facilitated Drug Release for Treatment of Breast Cancer

Author:
Wang, Kaiyuan; Yang, Bin; Ye, Hao; Zhang, Xuanbo; Song, Hang; Wang, Xia; Li, Na; Wei, Lin; Wang, Yu; Zhang, Haotian; Kan, Qiming; He, Zhonggui; Wang, Dun; Sun, Jin
Source:
ACS applied materials & interfaces 2019 v.11 no.21 pp. 18914-18922
ISSN:
1944-8252
Subject:
biosafety,   etc   ; breast neoplasms; catalytic activity; cytotoxicity; drug therapy; drugs; micelles; nanoparticles; neoplasm cells; polymers;     Show all 10 Subjects
Abstract:
... Although environment-sensitive prodrug-based nanoparticles (NPs) have developed rapidly, lots of prodrug NPs still show poor selectivity and efficiency of parent drug bioactivation because of tumor heterogeneity. Herein, self-strengthened bioactivating prodrug-based NPs are fabricated via co-encapsulation of oxidation-responsive thioether-linked linoleic acid-paclitaxel conjugates (PTX-S-LA) and β ...
DOI:
10.1021/acsami.9b03056

10. One-pot bottom-up fabrication of biocompatible PEGylated WS2 nanoparticles for CT-guided photothermal therapy of tumors in vivo

Author:
Wang, Jiang-Tao; Zhang, Wei; Wang, Wan-Bi; Wu, Yong-Juan; Zhou, Ling; Cao, Feng
Source:
Biochemical and biophysical research communications 2019 v.511 no.3 pp. 587-591
ISSN:
0006-291X
Subject:
biosafety,   etc   ; X-radiation; cytotoxicity; histology; image analysis; mice; nanoparticles; neoplasm cells; neoplasms; photothermotherapy; solubility; toxicity testing;     Show all 12 Subjects
Abstract:
... Tungsten disulfide (WS2), which enjoyed a good potential to be a promising clinical theranostic agent for cancer treatment, is still subject to the tedious synthesis procedure.Here, we reported a one-pot ‘bottom-up’ hydrothermal strategy for the fabrication of PEGylated WS2 nanoparticles (NPs). The WS2-PEG nanoparticles were characterized systematically. The CT imaging and photothermal therapy aga ...
DOI:
10.1016/j.bbrc.2019.01.009

11. Inverse Molecular Sentinel-Integrated Fiberoptic Sensor for Direct and in Situ Detection of miRNA Targets

Author:
Strobbia, Pietro; Ran, Yang; Crawford, Bridget M.; Cupil-Garcia, Vanessa; Zentella, Rodolfo; Wang, Hsin-Neng; Sun, Tai-Ping; Vo-Dinh, Tuan
Source:
Analytical chemistry 2019 v.91 no.9 pp. 6345-6352
ISSN:
1520-6882
Subject:
biosafety,   etc   ; Raman spectroscopy; bioengineering; biofuels; gold; leaf extracts; microRNA; monitoring; nanogold; optical fibers; sensors (equipment); washing;     Show all 12 Subjects
Abstract:
... Molecular advances have been made in analysis systems for a wide variety of applications ranging from biodiagnostics, biosafety, bioengineering, and biofuel research applications. There are, however, limited practical tools necessary for in situ and accurate detection of nucleic acid targets during field work. New technology is needed to translate these molecular advances from laboratory settings ...
DOI:
10.1021/acs.analchem.9b01350

12. Ebola Virus Aptamers: From Highly Efficient Selection to Application on Magnetism-Controlled Chips

Author:
Hong, Shao-Li; Xiang, Meng-Qi; Tang, Man; Pang, Dai-Wen; Zhang, Zhi-Ling
Source:
Analytical chemistry 2019 v.91 no.5 pp. 3367-3373
ISSN:
1520-6882
Subject:
biosafety,   etc   ; Ebolavirus; diagnostic techniques; dissociation; magnetism; mixing; oligonucleotides; point-of-care systems; proteins; washing;     Show all 10 Subjects
Abstract:
... Aptamers for Ebola virus (EBOV) offer a powerful means for prevention and diagnostics. Unfortunately, few aptamers for EBOV have been discovered yet. Herein, assisted by magnetism-controlled selection chips to strictly manipulate selection conditions, a highly efficient aptamer selection platform for EBOV is proposed. With highly stringent selection conditions of rigorous washing, manipulation of ...
DOI:
10.1021/acs.analchem.8b04623

13. pH-Sensitive morphological transitions in polymeric tadpole assemblies for programmed tumor therapy

Author:
Song, Cunfeng; Lin, Tongtong; Zhang, Qiang; Thayumanavan, S.; Ren, Lei
Source:
Journal of controlled release 2019 v.293 pp. 1-9
ISSN:
0168-3659
Subject:
biosafety,   etc   ; animal models; crosslinking; hydrophobicity; neoplasms; pH; paclitaxel; polymers; tadpoles; therapeutics;     Show all 10 Subjects
Abstract:
... Ultrafine single-chain tadpole polymers (SCTPs), containing an intrachain crosslinked globule and a pH-sensitive linear polymer chain, have been synthesized. Self-assembly of these polymers depends on the linear block length and the pH, at which the polymer is assembled. Although the SCTPs themselves exhibit a size that is consistent with a single-chain species, the self-assembled SCTPs were found ...
DOI:
10.1016/j.jconrel.2018.10.033

14. In Vivo Photoacoustic/Single-Photon Emission Computed Tomography Imaging for Dynamic Monitoring of Aggregation-Enhanced Photothermal Nanoagents

Author:
Wang, Yangyun; Sun, Ziling; Chen, Zhizhong; Wu, Yanxian; Gu, Yuan; Lin, Subin; Wang, Yong
Source:
Analytical chemistry 2019 v.91 no.3 pp. 2128-2134
ISSN:
1520-6882
Subject:
biosafety,   etc   ; biocompatibility; fibroins; image analysis; monitoring; neoplasms; photothermotherapy; planning; radionuclides; silk; tomography;     Show all 11 Subjects
Abstract:
... Emerging nanomedical strategy is to construct a nanoagent that affords not only diagnostic and therapeutic functions but also imaging-guided treatment. It is crucial to understand the in vivo biological processes of nanoagents for improving theranostic function and biosafety. Herein, we report a multimodal photoacoustic/single-photon emission computed tomography (SPECT) imaging technique to dynami ...
DOI:
10.1021/acs.analchem.8b04585

15. A comprehensive review on histone-mediated transfection for gene therapy

Author:
Han, Haobo; Yang, Jiebing; Chen, Wenqi; Li, Qing; Yang, Yan; Li, Quanshun
Source:
Biotechnology advances 2019 v.37 no.1 pp. 132-144
ISSN:
0734-9750
Subject:
biosafety,   etc   ; DNA; binding capacity; cytoplasm; gene therapy; genes; genetic engineering; histones; peptides; polymers; transfection;     Show all 11 Subjects
Abstract:
... Histone has been considered to be an effective carrier in non-viral gene delivery due to its unique properties such as efficient DNA binding ability, direct translocation to cytoplasm and favorable nuclear localization ability. Meanwhile, the rapid development of genetic engineering techniques could facilitate the construction of multifunctional fusion proteins based on histone molecules to furthe ...
DOI:
10.1016/j.biotechadv.2018.11.009

16. Protocol measuring horizontal gene transfer from algae to non-photosynthetic organisms

Author:
Lee, James Weifu
Source:
MethodsX 2019 v.6 pp. 1564-1574
ISSN:
2215-0161
Subject:
biosafety,   etc   ; Cyanobacteria; Escherichia coli; algae; bacteria; genetic engineering; genomics; horizontal gene transfer; plasmids; transgenes;     Show all 10 Subjects
Abstract:
... Horizontal gene transfer (HGT) is a natural process for an organism to transfer genetic material to another organism that is a completely different species, for example, from a blue-green alga to a non-photosynthetic bacterium. The phenomenon of HGT is not only of an interest to the science of molecular genetics and biology, but also to the biosafety issue of genetic engineering. The novel protoco ...
DOI:
10.1016/j.mex.2019.05.022

17. Recent Progress in CRISPR/Cas9 Technology

Author:
Mei, Yue; Wang, Yan; Chen, Huiqian; Sun, Zhong Sheng; Ju, Xing-Da
Source:
Journal of genetics and genomics 2016 v.43 no.2 pp. 63-75
ISSN:
1673-8527
Subject:
biosafety,   etc   ; RNA; ethics; genome;     Show all 4 Subjects
Abstract:
... The clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 system, a simple and efficient tool for genome editing, has experienced rapid progress in its technology and applicability in the past two years. Here, we review the recent advances in CRISPR/Cas9 technology and the ways that have been adopted to expand our capacity for precise genome manipulation. First, we introduce the  ...
DOI:
10.1016/j.jgg.2016.01.001

18. The nano-bio interaction and biomedical applications of carbon nanomaterials

Author:
Cui, Xuejing; Xu, Shaoxin; Wang, Xiaoyu; Chen, Chunying
Source:
Carbon 2018 v.138 pp. 436-450
ISSN:
0008-6223
Subject:
biosafety,   etc   ; carbon nanotubes; exocytosis; fullerene; graphene; humans; thermal properties; toxicity;     Show all 8 Subjects
Abstract:
... In the past decades, nanotechnology has stimulated a huge amount of interest and is now used in numerous fields. Carbon nanomaterials, like graphene, carbon nanotubes, and fullerenes, have attracted great attention for their widespread applications in diverse fields because of their excellent mechanical, optical, and thermal properties. With substantial production and use, potential human exposure ...
DOI:
10.1016/j.carbon.2018.07.069

19. Promising bacterial genera for agricultural practices: An insight on plant growth-promoting properties and microbial safety aspects

Author:
Ferreira, Carlos M.H.; Soares, Helena M.V.M.; Soares, Eduardo V.
Source:
The Science of the total environment 2019 v.682 pp. 779-799
ISSN:
0048-9697
Subject:
biosafety,   etc   ; Azospirillum; Azotobacter; Pantoea; Pseudomonas; Rhizobium; bacteria; biological hazards; chlorosis; crop yield; fertilizers; iron; nutrient deficiencies; pathogens; pesticides; siderophores;     Show all 16 Subjects
Abstract:
... In order to address the ever-increasing problem of the world's population food needs, the optimization of farming crops yield, the combat of iron deficiency in plants (chlorosis) and the elimination/reduction of crop pathogens are of key challenges to solve. Traditional ways of solving these problems are either unpractical on a large scale (e.g. use of manure) or are not environmental friendly (e. ...
DOI:
10.1016/j.scitotenv.2019.04.225

20. Detection of inorganic ions and organic molecules with cell-free biosensing systems

Author:
Zhang, Peng; Feng, Huibao; Yang, Junzhu; Jiang, Hao; Zhou, Hongjun; Lu, Yuan
Source:
Journal of biotechnology 2019 v.300 pp. 78-86
ISSN:
0168-1656
Subject:
biosafety,   etc   ; Escherichia coli; arsenic; benzoic acid; biosensors; cell free system; cell membranes; cytotoxicity; inorganic ions; magnesium; mercury; screening; translation (genetics);     Show all 13 Subjects
Abstract:
... Efforts to use genetically modified cells to detect inorganic ions and organic molecules have been hindered by biosafety concerns, limitation of cell membrane barriers, cytotoxicity problems, and unfriendly operations. To address those challenges, cell-free biosensing systems were established to detect arsenic, mercury, acyl-homoserine lactone, and benzoic acid in this study. The cell-free system ...
DOI:
10.1016/j.jbiotec.2019.05.011