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1. Correction to: Melanin biosynthesis in bacteria, regulation and production perspectives

Author:
Pavan, María Elisa; López, Nancy I.; Pettinari, M. Julia
Source:
Applied microbiology and biotechnology 2020 v.104 no.4 pp. 1821-1822
ISSN:
0175-7598
Subject:
biosynthesis,   etc   ; bacteria; melanin;     Show all 3 Subjects
Abstract:
... The original version of this article contains error for some of the authors corrections were not included during correction stage especially for Table 1. ...
DOI:
10.1007/s00253-019-10331-1

2. The Pathway Less Traveled: Engineering Biosynthesis of Nonstandard Functional Groups

Author:
Sulzbach, Morgan; Kunjapur, Aditya M.
Source:
Trends in biotechnology 2020 v.38 no.5 pp. 532-545
ISSN:
0167-7799
Subject:
biosynthesis,   etc   ; aldehydes; alkynes; hydrazine; metabolic engineering; moieties;     Show all 6 Subjects
Abstract:
... The field of metabolic engineering has achieved biochemical routes for conversion of renewable inputs to structurally diverse chemicals, but these products contain a limited number of chemical functional groups. In this review, we provide an overview of the progression of uncommon or ‘nonstandard’ functional groups from the elucidation of their biosynthetic machinery to the pathway optimization fr ...
DOI:
10.1016/j.tibtech.2019.12.014

3. Journey in the Polyphenol Research World with Ragai Ibrahim

Author:
Barron, Denis; Laflamme, Pierre; De Luca, Vincenzo
Source:
Journal of agricultural and food chemistry 2020 v.68 no.10 pp. 2849-2860
ISSN:
1520-5118
Subject:
biosynthesis,   etc   ; enzymology; genetics; polyphenols; students; Canada;     Show all 6 Subjects
Abstract:
... Dr. Ragai K. Ibrahim, Professor Emeritus at Concordia University, Montréal, Canada, passed away on the November 19, 2017 at the age of 88 years. Dr. Ibrahim dedicated his entire professional life to polyphenols and spent most of his academic career (1967–1997) at the Department of Biology of Concordia University in Montréal. He has been an active member of the Groupe Polyphénols since the begin ...
DOI:
10.1021/acs.jafc.9b06633

4. Dynamic NMR and Computational Studies Inform the Conformational Description of Dendrillane Terpenes from the Nudibranch Goniobranchus coi

Author:
Forster, Louise C.; Pierens, Gregory K.; Clegg, Jack K.; Garson, Mary J.
Source:
Journal of natural products 2020 v.83 no.3 pp. 714-719
ISSN:
1520-6025
Subject:
biosynthesis,   etc   ; Nudibranchia; molecular conformation; slugs; terpenoids;     Show all 5 Subjects
Abstract:
... Two new oxygenated terpenes (1 and 2) have been characterized from the Australian nudibranch Goniobranchus coi. Broadened ¹H NMR signals, together with the absence of individual carbon NMR signals, complicated analysis of 5,9-epoxydendrillolide A (1); increasing the temperature to 323 K revealed the missing NMR signals. Low-temperature ¹H NMR experiments provided an activation barrier of ∼15 kcal ...
DOI:
10.1021/acs.jnatprod.9b01051

5. Lipid synthesis and transport are coupled to regulate membrane lipid dynamics in the endoplasmic reticulum

Author:
Balla, Tamas; Sengupta, Nivedita; Kim, Yeun Ju
Source:
Biochimica et biophysica acta 2020 v.1865 no.1 pp. 158461
ISSN:
1388-1981
Subject:
biosynthesis,   etc   ; endoplasmic reticulum; lipids; physiological transport;     Show all 4 Subjects
Abstract:
... Structural lipids are mostly synthesized in the endoplasmic reticulum (ER), from which they are actively transported to the membranes of other organelles. Lipids can leave the ER through vesicular trafficking or non-vesicular lipid transfer and, curiously, both processes can be regulated either by the transported lipid cargos themselves or by different secondary lipid species. For most structural ...
DOI:
10.1016/j.bbalip.2019.05.005
PubMed:
31108203
PubMed Central:
PMC6858525

6. Unearthing Hidden Chemical Potential from Discarded Actinobacterial Libraries

Author:
Timmermans, Marshall L.; Ross, Avena C.
Source:
Trends in biotechnology 2020 v.38 no.1 pp. 7-9
ISSN:
0167-7799
Subject:
biosynthesis,   etc   ; antibiotics; bacteria; gene editing; mutants;     Show all 5 Subjects
Abstract:
... The redundancy of natural product biosynthesis in microbes poses a practical challenge for discovering new antimicrobial compounds from bacteria. The recent application of clustered regularly interspaced short palindromic repeats (CRISPR) technology by Culp et al. to inactivate the production of abundant antibiotics generates a metabolic clean slate for the detection and/or isolation of new and le ...
DOI:
10.1016/j.tibtech.2019.11.003

7. Microalgal Torrefaction for Solid Biofuel Production

Author:
Ho, Shih-Hsin; Zhang, Congyu; Tao, Fei; Zhang, Chaofan; Chen, Wei-Hsin
Source:
Trends in biotechnology 2020
ISSN:
0167-7799
Subject:
biosynthesis,   etc   ; biofuels; feedstocks; fuel production; microalgae; torrefaction;     Show all 6 Subjects
Abstract:
... Microalgae are recognized as promising feedstocks for biofuel production and have been intensively studied. However, a systematic investigation of the relationship between cellular components and fuel properties in microalgae is currently absent. This review introduces recent advances in microalgal torrefaction and critically evaluates the properties of torrefied products from the viewpoint of mol ...
DOI:
10.1016/j.tibtech.2020.02.009

8. Evolutionary innovations in starch metabolism

Author:
Abt, Melanie R; Zeeman, Samuel C
Source:
Current opinion in plant biology 2020 v.55 pp. 109-117
ISSN:
1369-5266
Subject:
biosynthesis,   etc   ; amylopectin; amylose; enzymes; polymers; proteins; starch granules;     Show all 7 Subjects
Abstract:
... The traditional view of starch metabolism has focused on the multiplicity of enzymes and enzyme isoforms contributing to the production of the constituent polymers, amylopectin and amylose. However, knowledge of these enzymes has not provided a full insight into many aspects of starch biosynthesis. This enzyme-centered view has recently been augmented by the discovery and characterization of novel ...
DOI:
10.1016/j.pbi.2020.03.001

9. Old Town Roads: routes of auxin biosynthesis across kingdoms

Author:
Morffy, Nicholas; Strader, Lucia C
Source:
Current opinion in plant biology 2020 v.55 pp. 21-27
ISSN:
1369-5266
Subject:
biosynthesis,   etc   ; Chlorophyta; bacteria; biochemical pathways; embryophytes; indole acetic acid; roads;     Show all 7 Subjects
Abstract:
... Auxin is an important signaling molecule synthesized in organisms from multiple kingdoms of life, including land plants, green algae, and bacteria. In this review, we highlight the similarities and differences in auxin biosynthesis among these organisms. Tryptophan-dependent routes to IAA are found in land plants, green algae and bacteria. Recent sequencing efforts show that the indole-3-pyruvic a ...
DOI:
10.1016/j.pbi.2020.02.002

10. Vps39 is required for ethanolamine-stimulated elevation in mitochondrial phosphatidylethanolamine

Author:
Iadarola, Donna M.; Basu Ball, Writoban; Trivedi, Prachi P.; Fu, Guo; Nan, Beiyan; Gohil, Vishal M.
Source:
Biochimica et biophysica acta 2020 v.1865 no.6 pp. 158655
ISSN:
1388-1981
Subject:
biosynthesis,   etc   ; biogenesis; endoplasmic reticulum; mitochondria; mitochondrial membrane; phosphatidylethanolamines; proteins; vacuoles;     Show all 8 Subjects
Abstract:
... Mitochondrial membrane biogenesis requires the import of phospholipids; however, the molecular mechanisms underlying this process remain elusive. Recent work has implicated membrane contact sites between the mitochondria, endoplasmic reticulum (ER), and vacuole in phospholipid transport. Utilizing a genetic approach focused on these membrane contact site proteins, we have discovered a ‘moonlightin ...
DOI:
10.1016/j.bbalip.2020.158655
PubMed:
32058032
PubMed Central:
PMC7209980

11. Fungi contain genes associated with flavonoid biosynthesis pathway

Author:
Mohanta, Tapan Kumar
Source:
Journal of functional foods 2020 v.68 pp. 103910
ISSN:
1756-4646
Subject:
biosynthesis,   etc   ; flavonoids; fruiting bodies; functional foods; genes; genomics; mushrooms; mycelium;     Show all 8 Subjects
Abstract:
... Mushroom is a fruiting body of fungi and hence it contains all the genomic architecture of its genome. The genomic architecture of the fruiting body is not separated from its mycelia. A manuscript by Alicia Gil-Ramirez entitled “Mushroom don't contain flavonoids” published by “Journal of Functional Foods” vol. 25, August 2016, page 1–13 (https://doi.org/10.1016/j.jff.2016.05.005) has exclusively m ...
DOI:
10.1016/j.jff.2020.103910

12. Recent advances in modular co-culture engineering for synthesis of natural products

Author:
Wang, Rufeng; Zhao, Shujuan; Wang, Zhengtao; Koffas, Mattheos AG
Source:
Current opinion in biotechnology 2020 v.62 pp. 65-71
ISSN:
0958-1669
Subject:
biosynthesis,   etc   ; Escherichia; biochemical pathways; coculture; energy; engineering; metabolites;     Show all 7 Subjects
Abstract:
... The microbial production of natural products has been traditionally accomplished in a single organism engineered to accommodate target biosynthetic pathways. Often times, such approaches result in large metabolic burdens as key cofactors, precursor metabolites and energy are channeled to pathways of structurally complex chemicals. Recently, modular co-culture engineering has emerged as a new appro ...
DOI:
10.1016/j.copbio.2019.09.004

13. Rheology-determined critical conditions for shear-induced crystallization of biosynthesized polyhydroxyalkanoates

Author:
Xu, Pengwu; Yang, Weijun; Niu, Deyu; Yu, Manman; Du, Mingliang; Dong, Weifu; Chen, Mingqing; Ma, Piming
Source:
International journal of biological macromolecules 2020 v.147 pp. 1301-1308
ISSN:
0141-8130
Subject:
biosynthesis,   etc   ; crystallization; manufacturing; melting; polyhydroxyalkanoates; rheological properties; rheometers; temperature;     Show all 8 Subjects
Abstract:
... Shear-induced crystallization plays a crucial role in the manufacturing process of polymers. In this work, crystallization kinetics of biosynthesized polyhydroxyalkanoates (PHA) under different shear conditions were systematically investigated by rheometers. First, rheological properties of PHA melts were performed at different temperature to obtain mastercurves via the time-temperature superposit ...
DOI:
10.1016/j.ijbiomac.2019.09.256

14. Identification and characterization of methyltransferases involved in benzylisoquinoline alkaloids biosynthesis from Stephania intermedia

Author:
Zhao, Wanli; Shen, Chen; Zhu, Jinqian; Ou, Chenhui; Liu, Manyu; Dai, Wenling; Liu, Xiufeng; Liu, Jihua
Source:
Biotechnology letters 2020 v.42 no.3 pp. 461-469
ISSN:
0141-5492
Subject:
biosynthesis,   etc   ; Escherichia coli; Stephania; alkaloids; catalytic activity; genes; methylation; methyltransferases;     Show all 8 Subjects
Abstract:
... OBJECTIVES: To characterize methyltransferases involved in the biosynthesis of benzylisoquinoline alkaloids in Stephania intermedia. RESULTS: Three N-methyltransferases, SiCNMT1, SiCNMT2, SiCNMT3, and O-methyltransferase SiSOMT were identified in Stephania intermedia. Then, four methyltransferase genes were cloned into the pGEX-6P-1 vector. The recombinant vectors were transformed into Escherichia ...
DOI:
10.1007/s10529-019-02785-0

15. Unraveling the Fungal Strategy for Tetrahydroxanthone Biosynthesis and Diversification

Author:
Wei, Xingxing; Matsuda, Yudai
Source:
Organic letters 2020 v.22 no.5 pp. 1919-1923
ISSN:
1523-7052
Subject:
biosynthesis,   etc   ; chemical reactions; fungi; isomerases; moieties; organic compounds;     Show all 6 Subjects
Abstract:
... In vivo and in vitro reconstitution of the biosynthesis of fungal tetrahydroxanthones (THXs), blennolides A and C, led to the identification and characterization of the key enzymes for THX biosynthesis and diversification. The unusual isomerase NsrQ plays a crucial role in the THX skeleton synthesis probably by catalyzing the 1,2-hydride shift and methyl group epimerization, thus allowing dearomat ...
DOI:
10.1021/acs.orglett.0c00285

16. De novo biosynthesis of indole-3-ethanol and indole-3-ethanol acetate in engineered Escherichia coli

Author:
Kong, Sijia; Zhang, Jianbi; Li, Xun; Pan, Hong; Guo, Daoyi
Source:
Biochemical engineering journal 2020 v.154 pp. 107432
ISSN:
1369-703X
Subject:
biosynthesis,   etc   ; Escherichia coli; acetates; acetyltransferases; alcohols; carbon; glucose; tryptophan;     Show all 8 Subjects
Abstract:
... Indole-3-ethanol is an important pharmaceutical intermediate that possess significant pharmaceutical properties. In this study, we established an artificial pathway in engineered Escherichia coli for microbial production of indole-3-ethanol from simple carbon sources. The overall pathway includes the upstream pathway from glucose to L-tryptophan and the downstream pathway from L-tryptophan to indo ...
DOI:
10.1016/j.bej.2019.107432

17. Stereoselective synthesis of MaR2n-3 DPA

Author:
Sønderskov, Jeanne; Tungen, Jørn E.; Palmas, Francesco; Dalli, Jesmond; Serhan, Charles N.; Stenstrøm, Yngve; Vidar Hansen, Trond
Source:
Tetrahedron letters 2020 v.61 no.7 pp. 151510
ISSN:
0040-4039
Subject:
biosynthesis,   etc   ; chemical reactions; geometry; moieties; organic compounds; stereoselective synthesis;     Show all 6 Subjects
Abstract:
... The first total synthesis of the n-3 docosapentaenoic derived oxygenated product MaR2ₙ₋₃ DPA has been achieved. The 13R and 14S stereogenic centers were introduced using 2-deoxy-d-ribose in a chiral pool strategy. The geometry of the Z,E,E-triene moiety was prepared using highly E-selective Wittig- and Takai-olefination reactions as well as the Z-stereoselective Lindlar reduction. LC/MS-MS data of ...
DOI:
10.1016/j.tetlet.2019.151510

18. Synthesis and structural revision of an indanone isolated from Triphyophyllum peltatum

Author:
Ishii, Yunosuke; Ota, Motohiro; Kamo, Shogo; Tomoshige, Shusuke; Tsubaki, Kazunori; Kuramochi, Kouji
Source:
Tetrahedron letters 2020 v.61 no.7 pp. 151494
ISSN:
0040-4039
Subject:
biosynthesis,   etc   ; Triphyophyllum peltatum; chemical reactions; chemical structure; indans; spectral analysis;     Show all 6 Subjects
Abstract:
... In this paper, skeletal rearrangements of 2-hydroxy-3-methyl-1,4-naphthoquinones to indanones are reported. The application of this reaction to the synthesis of an indanone isolated from root cultures of the West African liana Triphyophyllum peltatum is described. The spectroscopic data of this synthetic indanone are different from those reported for the natural product, indicating that the report ...
DOI:
10.1016/j.tetlet.2019.151494

19. Activation of paulomycin production by exogenous γ-butyrolactone signaling molecules in Streptomyces albidoflavus J1074

Author:
Zhang, Yuwei; Wang, Min; Tian, Jun; Liu, Jia; Guo, Zhengyan; Tang, Wei; Chen, Yihua
Source:
Applied microbiology and biotechnology 2020 v.104 no.4 pp. 1695-1705
ISSN:
0175-7598
Subject:
biosynthesis,   etc   ; Streptomyces albidoflavus; Streptomyces coelicolor; lactones; multigene family;     Show all 5 Subjects
Abstract:
... The interspecies communication roles of γ-butyrolactones (GBLs) have been described for a long time but are still poorly understood. Herein, we analyzed more than 1000 Streptomyces strains and noticed a big quantitative gap between the strains with GBL biosynthetic genes and the strains with GBL receptor genes, which implies the wide-spread of GBLs as interspecies signals in Streptomyces and their ...
DOI:
10.1007/s00253-019-10329-9

20. Induced cultivation pattern enhanced the phycoerythrin production in red alga Porphyridium purpureum [Erratum: Feb. 2020, v.43(2), p.357]

Author:
Xu, Yuanchao; Jiao, Kailin; Zhong, Huichang; Wu, Shengshan; Ho, Shih-Hsin; Zeng, Xianhai; Li, Jinglong; Tang, Xing; Sun, Yong; Lin, Lu
Source:
Bioprocess and biosystems engineering 2020 v.43 no.2 pp. 347-355
ISSN:
1615-7591
Subject:
biosynthesis,   etc   ; Porphyridium; biomass; light intensity; nitrates; phycoerythrin; temperature;     Show all 7 Subjects
Abstract:
... Porphyridium purpureum is a rich source for producing phycoerythrin (PE); however, the PE content is greatly affected by culture conditions. Researchers have aimed to optimize the cultivation of P. purpureum for accumulation of PE. When traditional optimized culture conditions were used to cultivate P. purpureum, high PE contents were not usually achieved. In this study, an induced cultivation pat ...
DOI:
10.1007/s00449-019-02230-6