PubAg

Main content area

You searched for: Subject "carcinogens" Remove constraint Subject: "carcinogens"
Start Over

Search

2,153  Search Results

« Previous | 1 - 20 of 2,153 |
Number of results to display per page

Search Results

1. 1,4-Dioxane in drinking water: emerging for 40 years and still unregulated

Author:
McElroy, Amie C.; Hyman, Michael R.; Knappe, Detlef R.U.
Source:
Current opinion in environmental science & health 2019 v.7 pp. 117-125
ISSN:
2468-5844
Subject:
carcinogens,   etc   ; analytical methods; dioxane; drinking water; water pollution; United States;     Show all 6 Subjects
Abstract:
... The likely human carcinogen 1,4-dioxane was first detected in drinking water more than 40 years ago, and a recent analysis suggests that almost 30 million people in the United States receive drinking water with 1,4-dioxane levels above the health-based reference concentration of 0.35 μg/L. The widespread occurrence of 1,4-dioxane has exposed the need for developing and implementing management and ...
DOI:
10.1016/j.coesh.2019.01.003

2. Human papillomavirus type 16 E6 and E7 gene variations associated with cervical cancer in a Han Chinese population

Author:
Zhou, Ziyun; Yang, Hongying; Yang, Lijuan; Yao, Yueting; Dai, Shuying; Shi, Li; Li, Chuanyin; Yang, Longyu; Yan, Zhiling; Yao, Yufeng
Source:
Infection, genetics, and evolution 2019 v.73 pp. 13-20
ISSN:
1567-1348
Subject:
carcinogens,   etc   ; Chinese people; Human papillomavirus 16; carcinogenesis; oncogenes; patients; uterine cervical neoplasms;     Show all 7 Subjects
Abstract:
... Human papillomavirus type 16 (HPV16) is a high-risk HPV subtype and a potent carcinogen. The HPV16 E6 and E7 genes are considered oncogenes that play a core role in the development of cervical cancer.In the current study, we enrolled 97 HPV16-positive cervical cancer patients (case group) and 136 HPV16-positive asymptomatic individuals (control group) in a study to analyse the association between ...
DOI:
10.1016/j.meegid.2019.04.008

3. Short-term and long-term exposure to hexavalent chromium alters 53BP1 via H3K18ac and H3K27ac

Author:
Ren, Xiaohu; Xia, Bo; Chen, Zhihong; Chen, Xiao; Wu, Desheng; Lu, Weixue; Luo, Nuanyuan; Zhou, Li; Liu, Wei; Yang, Xifei; Liu, Jianjun
Source:
Chemosphere 2019 v.229 pp. 284-294
ISSN:
0045-6535
Subject:
carcinogens,   etc   ; DNA damage; DNA repair; carcinogenesis; chromium; chronic exposure; epigenetics; epithelium; humans; oxidants; toxicity;     Show all 11 Subjects
Abstract:
... Hexavalent chromium (Cr(VI)) is a well-known human carcinogen and a strong oxidizer that causes severe DNA damage. However, the associations between epigenetic dysregulation and DNA damage have not been well-characterized. In this study, we evaluated the effects of short-term and long-term exposure to Cr(VI) in human bronchial epithelial (16HBE) cells. Then, we explored the role of epigenetic modi ...
DOI:
10.1016/j.chemosphere.2019.04.113

4. Enhancement of liquid chromatography-ion trap mass spectrometry analysis of 4(5)-methylimidazole in biscuits through derivatization with dansyl chloride

Author:
Wu, Chunjian; Wang, Li; Li, He; Yu, Shujuan
Source:
Journal of chromatography 2019 v.1596 pp. 1-7
ISSN:
0021-9673
Subject:
carcinogens,   etc   ; biscuits; derivatization; liquid chromatography; mass spectrometry; microextraction; solid phase extraction;     Show all 7 Subjects
Abstract:
... The presence of potential carcinogen 4(5)-Methylimidazole (4-MeI) in foods causes much concern, stressing the need of a sensitive determination means. Here, we proposed a high-sensitivity method to determine 4-MeI in biscuits using dansyl chloride derivatization and disperse liquid-liquid micro-extraction (DLLME) followed by a liquid chromatography-ion trap mass spectrometry (LC-IT-MS) analysis. T ...
DOI:
10.1016/j.chroma.2019.02.061

5. An ultrasensitive fluorescent probe for hydrazine detection and its application in water samples and living cells

Author:
Guo, Shao-Hua; Guo, Zhi-Qian; Wang, Cheng-Yun; Shen, Yongjia; Zhu, Wei-Hong
Source:
Tetrahedron 2019 v.75 no.18 pp. 2642-2646
ISSN:
0040-4020
Subject:
carcinogens,   etc   ; chemical reactions; colorimetry; coumarin; fluorescence; fluorescent dyes; humans; hydrazine; manufacturing; moieties; reducing agents; toxicity;     Show all 12 Subjects
Abstract:
... Hydrazine, as a strong reducing agent, has been extensively used in many industrial manufactures. However, it is a potential human carcinogen and an environmental contaminant due to its high toxicity. Therefore, developing an ultrasensitive method for determining hydrazine in real water and biosystems is of great significance. Herein, based on coumarin dye, a turn-on fluorescent probe Cou-1-N2H4, ...
DOI:
10.1016/j.tet.2019.03.022

6. A Compendium of Mutational Signatures of Environmental Agents

Author:
Kucab, Jill E.; Zou, Xueqing; Morganella, Sandro; Joel, Madeleine; Nanda, A. Scott; Nagy, Eszter; Gomez, Celine; Degasperi, Andrea; Harris, Rebecca; Jackson, Stephen P.; Arlt, Volker M.; Phillips, David H.; Nik-Zainal, Serena
Source:
Cell 2019 v.177 no.4 pp. 821-836.e16
ISSN:
0092-8674
Subject:
carcinogens,   etc   ; DNA; DNA damage; etiology; genome; humans; mutagens; mutation; neoplasms; stem cells; topography;     Show all 11 Subjects
Abstract:
... Whole-genome-sequencing (WGS) of human tumors has revealed distinct mutation patterns that hint at the causative origins of cancer. We examined mutational signatures in 324 WGS human-induced pluripotent stem cells exposed to 79 known or suspected environmental carcinogens. Forty-one yielded characteristic substitution mutational signatures. Some were similar to signatures found in human tumors. Ad ...
DOI:
10.1016/j.cell.2019.03.001

7. Gestational exposure to acrylamide inhibits mouse placental development in vivo

Author:
Yu, Dainan; Xie, Xingxing; Qiao, Bo; Ge, Wenjing; Gong, Lixin; Luo, Dan; Zhang, Dalei; Li, Yuezhen; Yang, Bei; Kuang, Haibin
Source:
Journal of hazardous materials 2019 v.367 pp. 160-170
ISSN:
0304-3894
Subject:
carcinogens,   etc   ; acrylamides; apoptosis; atrophy; foods; gene expression; genes; heat treatment; messenger RNA; mice; neurotoxicity; placenta; proteins;     Show all 13 Subjects
Abstract:
... Acrylamide, a carcinogen and neurotoxic substance, recently has been discovered in various heat-treated carbohydrate-rich foods. The aim of this study was to investigate the effects of acrylamide exposure on placental development. Pregnant mice received acrylamide by gavage at dosages of 0, 10, and 50 mg/kg/day from gestational days (GD) 3 until GD 8 or GD 13. The results showed that acrylamide fe ...
DOI:
10.1016/j.jhazmat.2018.12.061

8. Analysis of 4(5)-methylimidazole in soy sauce by a quick, easy, cheap, effective, rugged, and safe approach and liquid chromatography-mass spectrometry

Author:
Wu, Chunjian; Wang, Li; Li, He; Yu, Shujuan
Source:
Journal of chromatography 2019 v.1588 pp. 25-32
ISSN:
0021-9673
Subject:
carcinogens,   etc   ; acetonitrile; liquid chromatography; liquid-liquid extraction; markets; mass spectrometry; pH; solid phase extraction; soy sauce;     Show all 9 Subjects
Abstract:
... 4(5)-Methylimidazole (4(5)-MI) is a potential carcinogen with low molecule weight, highly polarity, and weak basicity. The traditional way to extract and clean-up 4(5)-MI in soy sauce using solid phase extraction is tedious and time consuming. Here we proposed a method for the determination of 4(5)-MI in soy sauce by combining a modified quick, easy, cheap, effective, rugged, and safe (QuEChERS) e ...
DOI:
10.1016/j.chroma.2018.12.036

9. Cooking with elaborate recipes can reduce the formation of mutagenic heterocyclic amines and promote co-mutagenic amines

Author:
Khan, Mohammad Rizwan; Busquets, Rosa; Naushad, Mu; Puignou, Lluís
Source:
Food additives & contaminants 2019 v.36 no.3 pp. 385-395
ISSN:
1944-0057
Subject:
carcinogens,   etc   ; amines; beef; cooking; fried meat; heterocyclic amines; ingredients; mutagens; oils; recipes;     Show all 10 Subjects
Abstract:
... Heterocyclic amines (HCAs) are foodborne carcinogens for which their formation is highly dependent on cooking conditions. HCAs have been commonly quantified in food items prepared with simple procedures. This approach is suitable for elucidating HCAs’ formation, but it only partially reflects the contamination in consumed food. In the current investigation, the generation of HCAs has been investig ...
DOI:
10.1080/19440049.2019.1571286

10. Estimation of radon release rate for an underground uranium mine ventilation shaft in China and radon distribution characteristics

Author:
Zhou, Qingzhi; Liu, Senlin; Xu, Lechang; Zhang, Hui; Xiao, Detao; Deng, Jun; Pan, Ziqiang
Source:
Journal of environmental radioactivity 2019 v.198 pp. 18-26
ISSN:
0265-931X
Subject:
carcinogens,   etc   ; air flow; case studies; humans; mining; monitoring; radioactivity; radionuclides; radon; uranium; China;     Show all 11 Subjects
Abstract:
... Radon, known to be a human carcinogen, is one of the most concerned radionuclides in uranium mining which need to be monitored and controlled. A large amount of radon is discharged to the atmosphere mainly through underground ventilation shafts for underground uranium mining. There are many studies on radon release of uranium mine, but the differences of the measured radon results are very big. In ...
DOI:
10.1016/j.jenvrad.2018.12.010

11. An electrochemical biosensor based on hemoglobin-oligonucleotides-modified electrode for detection of acrylamide in potato fries

Author:
Asnaashari, Maryam; Kenari, Reza Esmaeilzadeh; Farahmandfar, Reza; Abnous, Khalil; Taghdisi, Seyed Mohammad
Source:
Food chemistry 2019 v.271 pp. 54-61
ISSN:
0308-8146
Subject:
carcinogens,   etc   ; DNA; acrylamides; agarose; biosensors; electrodes; gels; gold; neurotoxins; oxidation; pH; potatoes; processed foods;     Show all 13 Subjects
Abstract:
... Acrylamide a neurotoxin and strong carcinogen, is found in various thermally processed foods. In this study, an electrochemical sensor for detection of acrylamide using double stranded DNA (dsDNA)/Hemoglobin (Hb)-modified screen printed gold electrode (SPGE) was designed. The immobilization of ssDNA1-SH on the surface of SPGE was confirmed by cyclic voltammetry, and the interaction between ssDNA2- ...
DOI:
10.1016/j.foodchem.2018.07.150

12. Detection of Hexavalent Chromium by Copper Sulfide Nanocomposites

Author:
Zhan, Meihong; Yu, Hongmei; Li, Lihua; Nguyen, David T.; Chen, Wei
Source:
Analytical chemistry 2019 v.91 no.3 pp. 2058-2065
ISSN:
1520-6882
Subject:
carcinogens,   etc   ; adsorbents; atomic absorption spectrometry; chromium; detection limit; food safety; humans; nanocomposites; silica;     Show all 9 Subjects
Abstract:
... Chromium (Cr) is a vital environmental contaminant. In environmental matrixes, Cr presents dominantly in hexavalent chromium [Cr(VI)] and trivalent chromium [Cr(III)], which are two different inorganic states. Cr(VI) is a well-known human carcinogen, while Cr(III) is a naturally occurring micronutrient for the human body. Hence, speciation of Cr is crucial for ensuring environmental water and food ...
DOI:
10.1021/acs.analchem.8b04501

13. Effects of explosive puffing process on the reduction of ochratoxin A in rice and oats

Author:
Lee, Hyun Jung; Kim, Singeun; Suh, Hyung Joo; Ryu, Dojin
Source:
Food control 2019 v.95 pp. 334-338
ISSN:
0956-7135
Subject:
carcinogens,   etc   ; bulk density; food processing; nephrotoxicity; oats; ochratoxin A; puffing; rice; snack foods; snacks; water content;     Show all 11 Subjects
Abstract:
... Ochratoxin A (OTA) represents one of the most widespread mycotoxins in agricultural commodities in the world and is considered as a possible human carcinogen with its potent nephrotoxicity. Since OTA is stable under most food processing conditions, it has been detected in a variety of cereal grains and their processed products. We investigated the effect of explosive puffing process on the reducti ...
DOI:
10.1016/j.foodcont.2018.08.004

14. Suggestion for a subdivision of processed meat products on the Danish market based on their content of carcinogenic compounds

Author:
Mejborn, Heddie; Hansen, Max; Biltoft-Jensen, Anja; Christensen, Tue; Ygil, Karin Hess; Olesen, Pelle Thonning
Source:
Meat science 2019 v.147 pp. 91-99
ISSN:
0309-1740
Subject:
carcinogens,   etc   ; carcinogenicity; ingredients; markets; meat consumption; neoplasms; processed meat; risk; salt content;     Show all 9 Subjects
Abstract:
... Carcinogenic effects in humans are ascribed to processed meat by organisations such as International Agency for Research on Cancer, World Cancer Research Fund and American Institute for Cancer Research. However, the term ‘processed meat’ covers a heterogenic group of products whose content of potential hazards differ considerably. To improve estimates of associations between processed meat intake ...
DOI:
10.1016/j.meatsci.2018.08.025

15. How did the US EPA and IARC reach diametrically opposed conclusions on the genotoxicity of glyphosate-based herbicides?

Author:
Benbrook, Charles M.
Source:
Environmental sciences Europe 2019 v.31 no.1 pp. 2
ISSN:
2190-4707
Subject:
carcinogens,   etc   ; DNA damage; United States Environmental Protection Agency; genotoxicity; glyphosate; human population; humans; metabolites; mutagens; oxidative stress; risk; sex hormones;     Show all 12 Subjects
Abstract:
... BACKGROUND: The US EPA considers glyphosate as “not likely to be carcinogenic to humans.” The International Agency for Research on Cancer (IARC) has classified glyphosate as “probably carcinogenic to humans (Group 2A).” EPA asserts that there is no convincing evidence that “glyphosate induces mutations in vivo via the oral route.” IARC concludes there is “strong evidence” that exposure to glyphosa ...
DOI:
10.1186/s12302-018-0184-7

16. Kinetic models of migration of melamine and formaldehyde from melamine kitchenware with data of liquid chromatography

Author:
Arce, M.M.; Sanllorente, S.; Ortiz, M.C.
Source:
Journal of chromatography 2019 v.1599 pp. 115-124
ISSN:
0021-9673
Subject:
carcinogens,   etc   ; acetic acid; aqueous solutions; formaldehyde; glass; guidelines; high performance liquid chromatography; kinetics; laws and regulations; manufacturing; melamine; resins; spectroscopy;     Show all 13 Subjects
Abstract:
... European legislation has established a specific migration limit (SML) of 15 mg kg−1 for formaldehyde and 2.5 mg kg−1 for melamine. Formaldehyde resins are used in the manufacture of melamine kitchenware. Formaldehyde is listed in group 1 of the IARC list of carcinogenic compounds. To determine the quantity of formaldehyde and melamine as potential migrants from different types of melamine kitchenw ...
DOI:
10.1016/j.chroma.2019.04.006

17. Electrochemical study of hydrazine oxidation by leaf-shaped copper oxide loaded on highly ordered mesoporous carbon composite

Author:
Wang, Lei; Meng, Tianjiao; Jia, Huixian; Feng, Yue; Gong, Tong; Wang, Huan; Zhang, Yufan
Source:
Journal of colloid and interface science 2019 v.549 pp. 98-104
ISSN:
0021-9797
Subject:
carcinogens,   etc   ; carbon; copper; cupric oxide; detection limit; electrochemistry; environmental monitoring; environmental protection; humans; hydrazine; oxidation; porous media; sensors (equipment); toxicity;     Show all 14 Subjects
Abstract:
... Hydrazine is a possible human carcinogen because of its hyper toxicity. Therefore, the determination of hydrazine is particularly important for environmental protection and public security. Electrochemical method for the detection of hydrazine has drawn great interests because of its high sensitivity, fast response time, simple operation, and low cost. In this work, a leaf-like copper oxide (CuO) ...
DOI:
10.1016/j.jcis.2019.04.063

18. Carcinogenicity assessment: Addressing the challenges of cancer and chemicals in the environment

Author:
Madia, Federica; Worth, Andrew; Whelan, Maurice; Corvi, Raffaella
Source:
Environment international 2019 v.128 pp. 417-429
ISSN:
0160-4120
Subject:
carcinogens,   etc   ; carcinogenicity; cardiovascular diseases; environmental monitoring; health status; lifestyle; medicine; morbidity; mortality; neoplasms; public health; risk; toxicity testing;     Show all 13 Subjects
Abstract:
... Cancer is a key public health concern, being the second leading cause of worldwide morbidity and mortality after cardiovascular diseases. At the global level, cancer prevalence, incidence and mortality rates are increasing. These trends are not fully explained by a growing and ageing population: with marked regional and socioeconomic disparities, lifestyle factors, the resources dedicated to preve ...
DOI:
10.1016/j.envint.2019.04.067

19. Occupational exposure to wood dust and risk of nasopharyngeal cancer: A systematic review and meta-analysis

Author:
Beigzadeh, Zahra; Pourhassan, Bahman; kalantary, Saba; Golbabaei, Farideh
Source:
Environmental research 2019 v.171 pp. 170-176
ISSN:
0013-9351
Subject:
carcinogens,   etc   ; carcinoma; case-control studies; databases; histology; humans; meta-analysis; models; occupational exposure; risk; systematic review; wood dust;     Show all 12 Subjects
Abstract:
... Nasopharyngeal cancer (NPC) is one of the most commonly occurring cancers in some regions. While wood dust is a confirmed human carcinogen, its association with NPC remains uncertain due to inconsistent findings in the related studies. We performed the first systematic review and meta-analysis on the epidemiological evidence to examine the association between occupational exposure to wood dust and ...
DOI:
10.1016/j.envres.2018.12.022

20. Modeling groundwater nitrate exposure in private wells of North Carolina for the Agricultural Health Study

Author:
Messier, Kyle P.; Wheeler, David C.; Flory, Abigail R.; Jones, Rena R.; Patel, Deven; Nolan, Bernard T.; Ward, Mary H.
Source:
The Science of the total environment 2019 v.655 pp. 512-519
ISSN:
0048-9697
Subject:
carcinogens,   etc   ; groundwater; groundwater contamination; humans; ingestion; kriging; linear models; neural networks; nitrates; prediction; support vector machines; wells; North Carolina;     Show all 13 Subjects
Abstract:
... Unregulated private wells in the United States are susceptible to many groundwater contaminants. Ingestion of nitrate, the most common anthropogenic private well contaminant in the United States, can lead to the endogenous formation of N-nitroso-compounds, which are known human carcinogens. In this study, we expand upon previous efforts to model private well groundwater nitrate concentration in No ...
DOI:
10.1016/j.scitotenv.2018.11.022