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1. PARP inhibition suppresses topoisomerase 1 poisoning induced Caspase-3 dependent cell death in zebrafish embryos

Author:
Tsikarishvili, Sophiko; Karapetian, Margarita; Kulikova, Nina; Zaalishvili, Giorgi
Source:
Biochemical and biophysical research communications 2021 v.550 pp. 166-170
ISSN:
0006-291X
Subject:
caspase-3,   etc   ; ; Danio rerio; apoptosis; biomedical research; models;     Show all 6 Subjects
Abstract:
... In the present study the role of poly(ADP)ribosylation on rubitecan induced caspase dependent cell death was evaluated. We show that Top1 poisoning by rubitecan induces caspase mediated apoptosis which was reduced by PARP inhibitor olaparib in zebrafish embryo. Collectively our data introduces zebrafish as a valuable model for PARP related biomedical research. ...
DOI:
10.1016/j.bbrc.2021.03.005

2. A novel proteolytic cleavage of ROCK 1 in cell death: Not only by caspases 3 and 7 but also by caspase 2

Author:
Özdemir, Aysun; İbişoğlu, Burçin; Şimay Demir, Yaprak Dilber; Benhür, Elifnur; Valipour, Farzaneh; Ark, Mustafa
Source:
Biochemical and biophysical research communications 2021 v.547 pp. 118-124
ISSN:
0006-291X
Subject:
caspase-3,   etc   ; apoptosis; myosin light chains; phosphorylation; proteolysis; research;     Show all 6 Subjects
Abstract:
... During apoptosis, myosin light chain phosphorylation induced by ROCK 1, activated by caspase 3-mediated cleavage, results in the formation of membrane blebs. Additionally, actin-myosin-based contraction induced by the activation of ROCK is involved in the apoptotic nuclear disintegration. In previous studies, it was reported that ROCK 1 was only cleaved by caspase 3 in cell death and caspase 7 was ...
DOI:
10.1016/j.bbrc.2021.02.024

3. Freezing-then-aging treatment improved the protein digestibility of beef in an in vitro infant digestion model

Author:
Lee, Seonmin; Jo, Kyung; Jeong, Hyun Gyung; Yong, Hae In; Choi, Yun-Sang; Kim, Dongjun; Jung, Samooel
Source:
Food chemistry 2021 v.350 pp. 129224
ISSN:
0308-8146
Subject:
caspase-3,   etc   ; actin; beef; cathepsin B; digesta; digestible protein; digestion; food chemistry; models; protein tertiary structure;     Show all 10 Subjects
Abstract:
... In vitro protein digestibility of freezing-then-aged beef was investigated in an infant digestion model. The treatments were divided into freezing-then-aging (FA) and aging-only (AO) groups. Carbonyl and total free sulfhydryl contents were the same between both groups for 14-day aging. Freezing had no effect on beef myofibrillar protein tertiary structure. Although caspase-3 activity did not diffe ...
DOI:
10.1016/j.foodchem.2021.129224

4. Cellular FADD-like IL-1β-converting enzyme-inhibitory protein attenuates myocardial ischemia/reperfusion injury via suppressing apoptosis and autophagy simultaneously

Author:
Liu, Di; Wu, Hui; Li, Yun Zhao; Yang, Jun; Yang, Jian; Ding, Jia Wang; Zhou, Gang; Zhang, Jing; Wang, Xin’an; Fan, Zhi Xing
Source:
Nutrition, metabolism, and cardiovascular diseases 2021 v.31 no.6 pp. 1916-1928
ISSN:
0939-4753
Subject:
caspase-3,   etc   ; animal models; apoptosis; autophagy; cardiomyocytes; hypoxia; metabolism; myocardial infarction; nutrition; reperfusion injury; viability; volume;     Show all 12 Subjects
Abstract:
... Myocardial ischemia/reperfusion injury (MI/RI) is a result of coronary revascularization, and often increases cell apoptosis and autophagy. Downregulated cellular FADD-like-IL-1β-converting enzyme-inhibitory protein (cFLIP) was associated with development of several myocardial diseases, whether overexpression of cFLIP can attenuate MI/RI remains unclear. This study aimed to determine the effects o ...
DOI:
10.1016/j.numecd.2021.02.026

5. Passive slow freezing is an efficacious and cost-effective alternative to controlled slow freezing for ovarian tissue cryopreservation

Author:
Lierman, S.; Bus, A.; Andries, S.; Trias, E.; Bols, P.E.J.; Tilleman, K.
Source:
Cryobiology 2021 v.100 pp. 164-172
ISSN:
0011-2240
Subject:
caspase-3,   etc   ; apoptosis; cell proliferation; cost effectiveness; cryobiology; cryopreservation; fibrosis; follicular development; humans; immunohistochemistry; risk; xenotransplantation;     Show all 12 Subjects
Abstract:
... We aimed to assess the feasibility of passive slow freezing (PSF using Mr. Frosty container, Nalgene) as an alternative to controlled slow rate freezing (CSF using (Freezal™, Air liquide)) for human ovarian tissue (OT) cryopreservation. Validation studies needed were determined after assessing the risk associated (EuroGTP-II ART tool) and were conducted in 66 OT samples from 10 transgender men age ...
DOI:
10.1016/j.cryobiol.2021.01.013

6. Lysosomal Fe2+contributes to myofibrillar protein degradation through mitochondrial-dysfunction-induced apoptosis

Author:
Chen, Cheng; Guo, Zhaobin; Ma, Guoyuan; Ma, Jibing; Zhang, Zhen; Yu, Qunli; Han, Ling
Source:
Lebensmittel-Wissenschaft + [i.e. und] Technologie 2021 v.143 pp. 111197
ISSN:
0023-6438
Subject:
caspase-3,   etc   ; ; apoptosis; calcium; cattle; chelating agents; deferoxamine; desmin; lipid peroxidation; mitochondria; muscles; protein degradation; tenderizing;     Show all 13 Subjects
Abstract:
... To verify the role of lysosomal Fe²⁺ in mitochondrial-dysfunction-mediated apoptosis and postmortem tenderization of bovine muscles, mitochondrial apoptotic factors, myofibrillar protein degradation, and μ-calpain activity were evaluated in the control group and the iron chelator desferrioxamine (DFO) group. The control group showed 1) increased mitochondrial swelling and lipid peroxidation by 47% ...
DOI:
10.1016/j.lwt.2021.111197

7. Regulation of docosahexaenoic acid-induced apoptosis of confluent endothelial cells: Contributions of MAPKs and caspases

Author:
Du, Youjia; Taylor, Carla G.; Aukema, Harold M.; Zahradka, Peter
Source:
Biochimica et biophysica acta 2021 v.1866 no.5 pp. 158902
ISSN:
1388-1981
Subject:
caspase-3,   etc   ; apoptosis; caspase-8; caspase-9; docosahexaenoic acid; homeostasis; humans; mitogen-activated protein kinase; viability;     Show all 9 Subjects
Abstract:
... Endothelial cells, which help to maintain vascular homeostasis, can be functionally modulated by polyunsaturated fatty acids. Previously, we reported that docosahexaenoic acid (DHA) reduced the viability of confluent EA.hy926 endothelial cells with caspase-3 activation. This study therefore examined the molecular mechanism by which DHA affects the viability of confluent cells, with a focus on the ...
DOI:
10.1016/j.bbalip.2021.158902

8. MiRNA‐429 alleviates ketamine‐induced neurotoxicity through targeting BAG5

Author:
Fan, Xiaodi; Bian, Wenchao; Liu, Meichen; Li, Jinjie; Wang, Yunyun
Source:
Environmental toxicology 2021 v.36 no.4 pp. 620-627
ISSN:
1520-4081
Subject:
caspase-3,   etc   ; ; apoptosis; dose response; ecotoxicology; ketamine; luciferase; microRNA; neurotoxicity; reactive oxygen species;     Show all 10 Subjects
Abstract:
... Ketamine is a kind of anesthetic broadly applied in clinic. However, growing evidence has indicated that ketamine may induce neurotoxicity. Previous studies showed that mircoRNAs (miRNAs) participate in various aspects of biological regulations. In our work, we aimed to reveal the role of miR‐429 in ketamine‐induced neurotoxicity. The qRT‐PCR was used to measure the miR‐429 levels in ketamine‐trea ...
DOI:
10.1002/tox.23066

9. A cerium oxide@metal–organic framework nanoenzyme as a tandem catalyst for enhanced photodynamic therapy

Author:
Liu, Jintong; Ye, Lin Yao; Xiong, Wei Hong; Liu, Tianrui; Yang, Hong; Lei, Jianping
Source:
Chemical communications 2021 v.57 no.22 pp. 2820-2823
ISSN:
1364-548X
Subject:
caspase-3,   etc   ; apoptosis; catalysts; catalytic activity; ceric oxide; cerium; coordination polymers; nanohybrids; photochemotherapy; precision medicine;     Show all 10 Subjects
Abstract:
... An O₂ self-evolving core–shell theranostic nanohybrid was developed by encapsulating a nanoenzyme cerium oxide (CeOₓ) in a metal–organic framework (MOF). The hybrid reveals a 9-fold higher apoptotic percentage than bare CeOₓ in a harsh hypoxic microenvironment through tandem homogenous catalysis. Simultaneously, the oxygen-promoted therapeutic efficiency was self-monitored by the hybrid with caspa ...
DOI:
10.1039/d1cc00001b

10. Relationship between p38 signaling pathway and arsenic-induced apoptosis: a meta-analysis

Author:
Wu, Liping; Li, Xi; Wei, Shaofeng; Hu, Ting; Wu, Changyan; Jian, Wen; Luo, Peng
Source:
Environmental geochemistry and health 2021 v.43 no.3 pp. 1213-1224
ISSN:
0269-4042
Subject:
caspase-3,   etc   ; apoptosis; arsenic; exposure duration; geochemistry; meta-analysis; therapeutics; transcription factors;     Show all 8 Subjects
Abstract:
... Arsenic exposure could induce apoptosis and cause related cancer. It was reported that p38 signaling pathway played a key transcriptional regulatory factor in arsenic-induced apoptosis. However, there were certain disputable questions about this point of opinion. Therefore, the relationship between p38 signaling pathway and arsenic-induced apoptosis was systematically reviewed and analyzed by meta ...
DOI:
10.1007/s10653-020-00646-8

11. Rutin directly affects stimulatory action of FSH on the ovarian cell

Author:
Sirotkin, Alexander V.; Pelleova, Betina; Fabova, Zuzana; Makovicky, Pavol; Alwasel, Saleh; Harrath, Abdel Halim
Source:
PharmaNutrition 2021 v.15 pp. 100247
ISSN:
2213-4344
Subject:
caspase-3,   etc   ; apoptosis; bioflavonoids; cell viability; cyclins; estradiol; immunocytochemistry; isoflavones; metabolites; progesterone; rutin; steroidogenesis; swine; testosterone;     Show all 14 Subjects
Abstract:
... The influence of plant isoflavone rutin (vitamin P) on healthy ovarian cells is unknown.We evaluated the effect of FSH alone, at various dose levels (0, 10, 100, or 1000 ng/mL), and in combination with rutin (10 μg/mL) on the markers of viability (trypan blue test), proliferation (expression of proliferating cell nuclear antigen, PCNA and cyclin B1), apoptosis (expression of Bcl-2-associated X pro ...
DOI:
10.1016/j.phanu.2020.100247

12. Senescent cells in rabbit, nutria and chinchilla testes—Results from histochemical and immunohistochemical studies

Author:
Lustofin, Krzysztof; Niedbala, Piotr; Pawlicki, Piotr; Tuz, Ryszard; Płachno, Bartosz J.; Profaska-Szymik, Magdalena; Galuszka, Anna; Stolarczyk, Piotr; Gorowska-Wojtowicz, Ewelina; Kotula-Balak, Malgorzata
Source:
Animal reproduction science 2021 v.226 pp. 106701
ISSN:
0378-4320
Subject:
caspase-3,   etc   ; Myocastor coypus; animal reproduction; cell senescence; cholesterol; immunohistochemistry; meiosis; polysaccharides; rabbits; testosterone;     Show all 10 Subjects
Abstract:
... Rabbit, nutria and chinchilla testes were evaluated to compare testicular cellular senescence. There were no major species-specific differences in structure of either seminiferous tubules or interstitial tissue. There, however, were occasional abnormalities in seminiferous tubule structure with there being multinucleated and exfoliated cells present in rabbit testes. Furthermore, there were semini ...
DOI:
10.1016/j.anireprosci.2021.106701

13. The toxic influence of silver and titanium dioxide nanoparticles on cultured ovarian granulosa cells

Author:
Sirotkin, Alexander V.; Bauer, Miroslav; Kadasi, Attila; Makovicky, Pavol; Scsukova, Sona
Source:
Reproductive Biology 2021 v.21 no.1 pp. 100467
ISSN:
1642-431X
Subject:
caspase-3,   etc   ; cyclins; granulosa cells; progesterone; silver; swine; titanium dioxide; toxicity;     Show all 8 Subjects
Abstract:
... The application of metal nanoparticles in modern society is growing, but there is insufficient data concerning their influence on reproductive processes and comparison of their biological activity. The present experiments aimed to compare the effects of silver and titanium dioxide nanoparticles (AgNPs and TiO2NPs) on ovarian granulosa cell functions. AgNPs and TiO2NPs were added to culture of porc ...
DOI:
10.1016/j.repbio.2020.100467

14. ABCE1 Regulates RNase L-Induced Autophagy during Viral Infections

Author:
Ramnani, Barkha; Manivannan, Praveen; Jaggernauth, Sarah; Malathi, Krishnamurthy
Source:
Viruses 2021 v.13 no.2
ISSN:
1999-4915
Subject:
caspase-3,   etc   ; ; antiviral properties; apoptosis; autophagy; cell proliferation; double-stranded RNA; interferons; ribonucleases; virus replication;     Show all 10 Subjects
Abstract:
... Host response to a viral infection includes the production of type I interferon (IFN) and the induction of interferon-stimulated genes that have broad antiviral effects. One of the key antiviral effectors is the IFN-inducible oligoadenylate synthetase/ribonuclease L (OAS/RNase L) pathway, which is activated by double-stranded RNA to synthesize unique oligoadenylates, 2-5A, to activate RNase L. RNa ...
DOI:
10.3390/v13020315

15. Evaluating Endosomal Escape of Caspase-3-Containing Nanomaterials Using Split GFP

Author:
Anson, Francesca; Liu, Bin; Kanjilal, Pintu; Wu, Peidong; Hardy, Jeanne A.; Thayumanavan, S.
Source:
Biomacromolecules 2021 v.22 no.3 pp. 1261-1272
ISSN:
1526-4602
Subject:
caspase-3,   etc   ; endocytosis; hydrophobicity; nanocarriers; nanogels; peptides; polymers; porous media; silica;     Show all 9 Subjects
Abstract:
... The ability for biologics to access intracellular targets hinges on the translocation of active, unmodified proteins. This is often achieved using nanoscale formulations, which enter cells through endocytosis. This uptake mechanism often limits the therapeutic potential of the biologics, as the propensity of the nanocarrier to escape the endosome becomes the key determinant. To appropriately evalu ...
DOI:
10.1021/acs.biomac.0c01767

16. MicroRNA-210 Regulates Endoplasmic Reticulum Stress and Apoptosis in Porcine Embryos

Author:
Ridlo, Muhammad Rosyid; Kim, Eui Hyun; Kim, Geon A.
Source:
Animals 2021 v.11 no.1
ISSN:
2076-2615
Subject:
caspase-3,   etc   ; apoptosis; blastocyst; embryogenesis; endoplasmic reticulum; endoplasmic reticulum stress; inflammation; microRNA; swine;     Show all 9 Subjects
Abstract:
... Endoplasmic reticulum (ER) stress can be triggered during in vitro embryo production and is a major obstacle to embryo survival. MicroRNA (miR)-210 is associated with cellular adaptation to cellular stress and inflammation. An experiment was conducted to understand the effects of miR-210 on in vitro embryo development, ER stress, and apoptosis; to achieve this, miR-210 was microinjected into parth ...
DOI:
10.3390/ani11010221

17. Identification and Functional Analysis of Apoptotic Protease Activating Factor-1 (Apaf-1) from Spodoptera litura

Author:
Ma, Haihao; Yan, Xiumei; Yan, Lin; Zhao, Jingyan; Song, Jiping; Peng, Rong; Yang, Yongbo; Peng, Jianxin; Liu, Kaiyu
Source:
Insects 2021 v.12 no.1
ISSN:
2075-4450
Subject:
caspase-3,   etc   ; Nematoda; Spodoptera litura; actinomycin D; apoptosis; calorimetry; caspase-9; fruits; mammals; titration;     Show all 10 Subjects
Abstract:
... Apoptotic protease activating factor-1 (Apaf-1) is an adaptor molecule, essential for activating initiator caspase and downstream effector caspases, which directly cause apoptosis. In fruit flies, nematodes, and mammals, Apaf-1 has been extensively studied. However, the structure and function of Apaf-1 in Lepidoptera remain unclear. This study identified a novel Apaf-1 from Spodoptera litura, name ...
DOI:
10.3390/insects12010064

18. Contribution of glutaredoxin-1 to Fas s-glutathionylation and inflammation in ethanol-induced liver injury

Author:
Sun, Xiaomin; Ye, Cuilian; Deng, Qin; Chen, Jingyu; Guo, Chunbao
Source:
Life sciences 2021 v.264 pp. 118678
ISSN:
0024-3205
Subject:
caspase-3,   etc   ; alanine transaminase; apoptosis; aspartate transaminase; cytokines; ethanol; inflammation; liver; oxidative toxicity;     Show all 9 Subjects
Abstract:
... The reversible protein S-glutathionylation (PSSG) modification of Fas augments apoptosis, which can be reversed by the cytosolic deglutathionylation enzyme glutaredoxin-1 (Grx1), but its roles in alcoholic liver injury remain unknown. Therefore, the objective of this study was to investigate the impact of genetic ablation of Grx1 on Fas S-glutathionylation (Fas-SSG) in regulating ethanol-induced i ...
DOI:
10.1016/j.lfs.2020.118678

19. Influence of high-intensity interval training and intermittent fasting on myocardium apoptosis pathway and cardiac morphology of healthy rats

Author:
Carvalho, Marianna R.; Mendonça, Maria Lua M.; Oliveira, Jéssica M.L.; Romanenghi, Rodrigo B.; Morais, Camila S.; Ota, Gabriel E.; Lima, Aline R.R.; Oliveira, Rodrigo J.; Filiú, Wander F.O.; Okoshi, Katashi; Okoshi, Marina P.; Oliveira-Junior, Silvio A.; Martinez, Paula F.
Source:
Life sciences 2021 v.264 pp. 118697
ISSN:
0024-3205
Subject:
caspase-3,   etc   ; apoptosis; cardiomyocytes; caspase-8; collagen; fasting; fibrosis; hypertrophy; pro-apoptotic proteins; rats;     Show all 10 Subjects
Abstract:
... To evaluate the influence of intermittent fasting and high-intensity interval training (HIIT) on myocardial apoptosis signaling and cardiac morphological characteristics in healthy rats.Male Wistar rats (n = 60) were divided into four groups: sedentary control (SED-C), intermittent fasting (SED-IF), high-intensity interval training (HIIT-C), and high-intensity interval training plus intermittent f ...
DOI:
10.1016/j.lfs.2020.118697

20. Optineurin modulates ER stress-induced signaling pathways and cell death

Author:
Ramachandran, Gopalakrishna; Moharir, Shivranjani C.; Raghunand, Tirumalai R.; Swarup, Ghanshyam
Source:
Biochemical and biophysical research communications 2021 v.534 pp. 297-302
ISSN:
0006-291X
Subject:
caspase-3,   etc   ; autophagy; brain; cortex; endoplasmic reticulum; fibroblasts; liver; mice; research; stress response; tunicamycin;     Show all 11 Subjects
Abstract:
... We have investigated the physiological role of the autophagy receptor Optineurin/Optn in endoplasmic reticulum (ER) stress response using cellular and animal models. In comparison to their normal counterparts, Optn-deficient mouse embryonic fibroblasts showed significantly higher cell death and caspase-3 activation upon treatment with tunicamycin and thapsigargin, inducers of ER stress. The transc ...
DOI:
10.1016/j.bbrc.2020.11.091