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1. Thiophanate-methyl induces severe hepatotoxicity in zebrafish

Author:
Jia, Kun; Cheng, Bo; Huang, Lirong; Xiao, Juhua; Bai, Zhonghui; Liao, Xinjun; Cao, Zigang; Shen, Tianzhu; Zhang, Chunping; Hu, Chengyu; Lu, Huiqiang
Source:
Chemosphere 2020 v.248 pp. 125941
ISSN:
0045-6535
Subject:
caspase-3,   etc   ; Danio rerio; adults; apoptosis; fish larvae; hepatotoxicity; liver; oxidative stress; pesticide residues; thiophanate-methyl;     Show all 10 Subjects
Abstract:
... Thiophanate-methyl (TM) is widely used all over the world and is a typical example of pesticide residues, which can be detected in the soil, and even in vegetables and fruits. However, the molecular mechanisms underlying the hepatotoxicity of TM are not well understood. In this study, we utilized zebrafish to comprehensively evaluate the hepatotoxicity of TM and explore how the molecular mechanism ...
DOI:
10.1016/j.chemosphere.2020.125941

2. Multigenerational effects of cadmium on the lifespan and fertility of Drosophila melanogaster

Author:
Yang, Xingran; Han, Yan; Mu, Yun; Yang, Pingping; Gu, Wei; Zhang, Min
Source:
Chemosphere 2020 v.245 pp. 125533
ISSN:
0045-6535
Subject:
caspase-3,   etc   ; Drosophila melanogaster; apoptosis; cadmium; chronic toxicity; epigenetics; genes; genetic engineering; longevity; progeny;     Show all 10 Subjects
Abstract:
... Although the damage and tolerance mechanisms of Cd stress are known, the data on genetic risk are limited. The aim of this study was to assess the chronic toxicity of Cd, genetic responses, and multigenerational effects in five generations of Drosophila melanogaster. For each generation, lifespan and fertility were statistically analysed and the expression of apoptosis- (p53 and caspase-3) and epi ...
DOI:
10.1016/j.chemosphere.2019.125533

3. Manganese modifies Neurotrophin-3 (NT3) and its tropomyosin receptor kinase C (TrkC) in the cortex: Implications for manganese-induced neurotoxicity

Author:
Yang, Yiping; Wei, Fu; Wang, Jian; Chen, Rui; Zhang, Jie; Li, Danni; Gan, Dong; Yang, Xiaobo; Zou, Yunfeng
Source:
Food and chemical toxicology 2020 v.135 pp. 110925
ISSN:
0278-6915
Subject:
caspase-3,   etc   ; apoptosis; cortex; ligands; manganese; mitogen-activated protein kinase; neurons; neurotoxicity; signal transduction; tropomyosins;     Show all 10 Subjects
Abstract:
... Manganese (Mn), an essential micronutrient, has the potential to induce apoptosis. The NT3/TrkC ligand/receptor pair known as part of the classic neurotrophic theory plays a critical role in neuronal survival. However, whether the NT3/TrkC-mediated signaling pathways are involved in Mn-induced apoptosis of cortical neurons remains unknown. The present study was designed to investigate the interact ...
DOI:
10.1016/j.fct.2019.110925

4. Effects of multi-walled carbon nanotubes on the enantioselective toxicity of the chiral insecticide indoxacarb toward zebrafish (Danio rerio)

Author:
Wang, Ju; Jia, Bo; Li, Yanhong; Ren, Bo; Liang, Hanlin; Yan, Dongyan; Xie, Haiyan; Zhang, Xiaodong; Liang, Hongwu
Source:
Journal of hazardous materials 2020 v.397 pp. 122724
ISSN:
0304-3894
Subject:
caspase-3,   etc   ; Danio rerio; apoptosis; brain; carbon nanotubes; enantioselectivity; females; fish; gene expression; genes; indoxacarb; liver; males; models; pollutants; toxicity;     Show all 16 Subjects
Abstract:
... The mass production and usage of carbon nanotubes (CNTs) have led to the inevitable release into the environment, and the effects of CNTs on the toxicity of co-existing pollutants have been well documented. However, knowledge of the effects of CNTs on the enantioselective toxicity of chiral compounds is limited. Using zebrafish as an experimental model, the enantioselective expression of the apopt ...
DOI:
10.1016/j.jhazmat.2020.122724

5. Involvement of protein S-nitrosylation in regulating beef apoptosis during postmortem aging

Author:
Hou, Qin; Liu, Rui; Tian, Xiaona; Zhang, Wangang
Source:
Food chemistry 2020 v.326 pp. 126975
ISSN:
0308-8146
Subject:
caspase-3,   etc   ; S-nitrosylation; apoptosis; beef; chromatin; enzyme inhibitors; meat aging; muscles; nitric oxide; nitric oxide synthase;     Show all 10 Subjects
Abstract:
... This study was the first attempt to explore the effect of protein S-nitrosylation on the progress of apoptosis in postmortem beef semimembranosus muscle (SM). Five beef SM were incubated with S-nitrosoglutathione (GSNO, nitric oxide donor), control, or Nω-nitro-l-arginine methyl ester hydrochloride (l-NAME, nitric oxide synthase inhibitor). Results suggest that compared to the control, more chroma ...
DOI:
10.1016/j.foodchem.2020.126975

6. Regulation of taurine in OTA-induced apoptosis and autophagy

Author:
Liu, Kai; Mao, Xinru; Li, Hu; Liu, Dandan; Le, Guannan; Gan, Fang; Pan, Cuiling; Huang, Kehe; Chen, Xingxiang
Source:
Toxicon 2020 v.181 pp. 82-90
ISSN:
0041-0101
Subject:
caspase-3,   etc   ; apoptosis; autophagy; cytotoxicity; fluorescence; homeostasis; humans; nephrotoxicity; ochratoxin A; protein synthesis; proteins; staining; taurine; toxicology;     Show all 14 Subjects
Abstract:
... Ochratoxin A (OTA), one of the most deleterious mycotoxins, could cause a variety of toxicological effects especially nephrotoxicity in animals and humans. Taurine, a wide-distributed cytoprotective amino acid, plays an important role as a basic factor for maintaining cellular integrity homeostasis. However, the potential effect of taurine in OTA-induced nephrotoxicity remains unknown. In the pres ...
DOI:
10.1016/j.toxicon.2020.04.097

7. Calreticulin regulated intrinsic apoptosis through mitochondria-dependent and independent pathways mediated by ER stress in arsenite exposed HT-22 cells

Author:
Wang, Xiaotong; Liu, Xudan; Chen, Yao; Wang, Huanhuan; Zhang, Ruo; Zhang, Qianhui; Wei, Yuting; Shi, Sainan; Li, Xin
Source:
Chemosphere 2020 v.251 pp. 126466
ISSN:
0045-6535
Subject:
caspase-3,   etc   ; apoptosis; arsenic; arsenites; calreticulin; cell lines; chronic exposure; dose response; endoplasmic reticulum; mice; neurotoxicity; quality control; signal transduction;     Show all 13 Subjects
Abstract:
... Arsenic is a naturally occurring environmental toxicant. Chronic exposure to arsenic is linked with neurological damage. Although the mechanisms remain to be elucidated, it is currently believed that neural cell apoptosis is one of the underlying mechanisms of arsenic-induced neurotoxicity. Calreticulin (CRT) is a quality control chaperone located in the lumen of the endoplasmic reticulum (ER), wh ...
DOI:
10.1016/j.chemosphere.2020.126466

8. Encapsulation of phycocyanin by prebiotics and polysaccharides-based electrospun fibers and improved colon cancer prevention effects

Author:
Wen, Yan; Wen, Peng; Hu, Teng-Gen; Linhardt, Robert J.; Zong, Min-Hua; Wu, Hong; Chen, Zhi-Yi
Source:
International journal of biological macromolecules 2020 v.149 pp. 672-681
ISSN:
0141-8130
Subject:
caspase-3,   etc   ; apoptosis; bioactive properties; colon; colorectal neoplasms; cyclins; cytochrome c; encapsulation; inhibitory concentration 50; interphase; mitochondria; models; phycocyanin; prebiotics;     Show all 14 Subjects
Abstract:
... To preserve bioactivity and achieve colon targeted release of phycocyanin (PC), the polysaccharides-based electrospun fiber mat (EFM) containing PC and prebiotics was prepared and characterized. In vitro release tests confirmed the colon targeting behavior of PC, in particular, faster release of PC was achieved due to the addition of prebiotics. Ritger–Peppas model confirmed that the release of PC ...
DOI:
10.1016/j.ijbiomac.2020.01.189

9. Bnip3 mediates doxorubicin-induced cardiomyocyte pyroptosis via caspase-3/GSDME

Author:
Zheng, Xinbin; Zhong, Ting; Ma, Yeshuo; Wan, Xiaoya; Qin, Anna; Yao, Bifeng; Zou, Huajiao; Song, Yan; Yin, Deling
Source:
Life sciences 2020 v.242 pp. 117186
ISSN:
0024-3205
Subject:
caspase-3,   etc   ; Adenoviridae; Western blotting; cardiac output; cardiomyocytes; cardiotoxicity; doxorubicin; echocardiography; flow cytometry; models; protein content; pyroptosis; staining; therapeutics; transfection;     Show all 15 Subjects
Abstract:
... This study was aimed to investigate the role of GSDME-mediated pyroptosis in cardiac injury induced by Doxorubicin (DOX), and to evaluate the role of BH3-only protein Bcl-2/adenovirus E1B 19-kDa-interacting protein 3 (Bnip3) in regulation of DOX-induced pyroptosis.HL-1 cardiomyocytes and C57BL/6J mice were treated by DOX to establish DOX-induced cardiotoxicity in vitro and in vivo models, respecti ...
DOI:
10.1016/j.lfs.2019.117186

10. Enhancement of autophagy flux by isopsoralen ameliorates interleukin-1β-stimulated apoptosis in rat chondrocytes

Author:
Chen, Zhi; Li, Chen; Qian, Yi-Hong; Fu, Yang; Feng, Zi-Ming
Source:
Journal of Asian natural products research 2020 v.22 no.2 pp. 179-192
ISSN:
1477-2213
Subject:
caspase-3,   etc   ; DNA fragmentation; apoptosis; autophagy; cartilage; chondrocytes; enzyme activity; interleukin-1beta; osteoarthritis; pathogenesis; protective effect; proteins; rats;     Show all 13 Subjects
Abstract:
... Chondrocyte apoptosis contributes to the pathogenesis of cartilage degeneration in osteoarthritis (OA). We found that isopsoralen pretreatment significantly reversed the increase in DNA fragmentation and apoptosis rate, and significantly decreased the caspase-3 activity and PARP cleavage in IL-1β-treated chondrocytes. Isopsoralen pretreatment markedly inhibited disruption of matrix proteins. Moreo ...
DOI:
10.1080/10286020.2018.1537265

11. MiR-499 inhibited hypoxia/reoxygenation induced cardiomyocytes injury by targeting SOX6

Author:
Shi, Yujie; Han, Yunfeng; Niu, Lili; Li, Junxia; Chen, Yundai
Source:
Biotechnology letters 2019 v.41 no.6-7 pp. 837-847
ISSN:
0141-5492
Subject:
caspase-3,   etc   ; apoptosis; cardiomyocytes; genes; hypoxia; myocardial infarction; therapeutics;     Show all 7 Subjects
Abstract:
... OBJECTIVE: MiR-499 has been reported to be expressed only in cardiomyocytes, and its expression would increase after acute myocardial infarction (AMI). miR-499 plays a role in the process of cardiomyocytes injury induced by hypoxia/reoxygenation (H/R), however, it still remains unclear. RESULTS: Hypoxia inhibited miR-499-5p expression and H/R induced apoptosis. SOX6 was a target gene of miR-499-5p ...
DOI:
10.1007/s10529-019-02685-3
PubMed:
31076992
PubMed Central:
PMC6551346

12. A trienone analog of curcumin, 1,7-bis(3-hydroxyphenyl)-1,4,6-heptatrien-3-one, possesses ROS- and caspase-mediated apoptosis in human oral squamous cell carcinoma cells in vitro

Author:
Utaipan, Tanyarath; Boonyanuphong, Piyawan; Chuprajob, Thipphawan; Suksamrarn, Apichart; Chunglok, Warangkana
Source:
Applied biological chemistry 2020 v.63 no.1 pp. 7
ISSN:
2468-0834
Subject:
caspase-3,   etc   ; acetylcysteine; antineoplastic agents; apoptosis; caspase-9; curcumin; cytotoxicity; drug therapy; humans; metastasis; mouth neoplasms; multiple drug resistance; neoplasm cells; reactive oxygen species; squamous cell carcinoma;     Show all 15 Subjects
Abstract:
... The leading causes of oral cancer treatment failure are cancer metastasis and chemotherapeutic resistance. Thus, developing novel anticancer agents that are effective against those aggressive cancer cells would be important for complementary or alternative treatments. The objective of this study was to investigate cytotoxicity and anticancer mechanisms of a synthetic trienone analog of curcumin, 1 ...
DOI:
10.1186/s13765-020-0491-8

13. OsVPE3 Mediates GA-induced Programmed Cell Death in Rice Aleurone Layers via Interacting with Actin Microfilaments

Author:
Zhang, Heting; Xiao, Yu; Deng, Xiaojiang; Feng, Hongyu; Li, Zhe; Zhang, Lulu; Chen, Huiping
Source:
Rice 2020 v.13 no.1 pp. 22
ISSN:
1939-8425
Subject:
caspase-3,   etc   ; Oryza sativa; actin; caspase-1; depolymerization; enzyme activity; enzyme inhibitors; gene expression; gene expression regulation; gibberellins; microfilaments; polymerization; programmed cell death; rice; vacuoles;     Show all 15 Subjects
Abstract:
... BACKGROUND: Vacuolar processing enzymes (VPEs) have been identified as the enzymes that regulate vacuole-mediated programmed cell death (PCD) in plants. The mechanism that VPE regulates the PCD in rice aleurone layers remains unknown. RESULTS: The aleurone layers treated with distilled water exerted caspase-1 and VPE activity, both of which were inhibited by the caspase-1 specific inhibitor Ac-YVA ...
DOI:
10.1186/s12284-020-00376-6
PubMed:
32232682
PubMed Central:
PMC7105518

14. The activation of antioxidant and apoptosis pathways involved in damage of human proximal tubule epithelial cells by PM2.5 exposure

Author:
Huang, Xiaoliu; Shi, Xiujuan; Zhou, Ji; Li, Sen; Zhang, Lijuan; Zhao, Huijun; Kuang, Xingya; Li, Jue
Source:
Environmental sciences Europe 2020 v.32 no.1 pp. 2
ISSN:
2190-4707
Subject:
caspase-3,   etc   ; apoptosis; caspase-8; cell viability; cytotoxicity; dose response; epithelial cells; kidneys; nephrotoxicity; oxidative stress; particulates; pro-apoptotic proteins; reactive oxygen species; renal function;     Show all 14 Subjects
Abstract:
... BACKGROUND: Exposure to airborne fine particulate matter (PM₂.₅) has been reported to be harmful to the human kidney. However, whether the activation of oxidative stress and cell apoptosis plays key roles in the nephrotoxicity caused by PM₂.₅ exposure is still poorly understood. The aim of this study was to explore the mechanism of cytotoxicity after PM₂.₅ exposure in human proximal tubule epithel ...
DOI:
10.1186/s12302-019-0284-z

15. Agrimonia pilosa polysaccharide and its sulfate derives facilitate cell proliferation and osteogenic differentiation of MC3T3-E1 cells by targeting miR-107

Author:
Huang, Wei; Jin, Shengyang; Yang, Wenbo; Tian, Shuo; Meng, Chunqing; Deng, Huan; Wang, Chong; Wang, Hong
Source:
International journal of biological macromolecules 2020 v.157 pp. 616-625
ISSN:
0141-8130
Subject:
caspase-3,   etc   ; Agrimonia pilosa; apoptosis; beta catenin; bone formation; cell proliferation; collagen; cytochrome c; cytotoxicity; dexamethasone; femur; in vitro studies; osteonecrosis; polysaccharides; protein synthesis; rats; sulfates; transfection;     Show all 18 Subjects
Abstract:
... The present study showed that low level of miR-107 in femoral head tissues from rats suffering steroid-induced osteonecrosis of the femoral head (SANFH) was associated with high degree of osteonecrosis and apoptosis. In vitro assay, pretreatment with an Agrimonia pilos polysaccharide (APP-AW) and its sulphated derivatives (S2) at 50 μg/ml for 48 h or overexpressing miR-107 were able to prevent cyt ...
DOI:
10.1016/j.ijbiomac.2019.11.213

16. Structural characterization and neuroprotective effect of a polysaccharide from Corydalis yanhusuo

Author:
He, Yufeng; Xu, Wenzhong; Qin, Yimin
Source:
International journal of biological macromolecules 2020 v.157 pp. 759-768
ISSN:
0141-8130
Subject:
caspase-3,   etc   ; Corydalis yanhusuo; DNA fragmentation; apoptosis; caspase-8; caspase-9; cytochrome c; death domain receptors; lactate dehydrogenase; mitochondria; neuroprotective effect; neurotoxicity; polysaccharides; protein synthesis;     Show all 14 Subjects
Abstract:
... In the present study, we investigated the neuroprotective effects of a purified Corydalis yanhusuo polysaccharide (CYP) on Aβ ₍₂₅–₃₅₎-induced neurotoxicity and explored its underlying molecular mechanisms in PC12 cells. The results showed pretreatment with CYP (25, 50, and 100 μg/ml) prior to Aβ ₍₂₅–₃₅₎ exposure significantly protected PC12 cells from Aβ ₍₂₅–₃₅₎-induced cell death, lactate dehydro ...
DOI:
10.1016/j.ijbiomac.2020.01.180

17. Fat-1 expression enhance hippocampal memory in scopolamine-induced amnesia

Author:
Hwang, Tae Woong; Kim, Eun-Ji; Kim, DaBi; Jeong, Jin Young; Kim, Gun-Hwa; Lim, Kyu; Moon, Minho; Yoon, Kyung Ah; Choi, Dae Eun; Kim, Jwa-Jin
Source:
The Journal of nutritional biochemistry 2020 v.82 pp. 108394
ISSN:
0955-2863
Subject:
caspase-3,   etc   ; Western blotting; amnesia; apoptosis; cell viability; cyclic AMP; gene expression; genes; hippocampus; memory; mice; neurogenesis; omega-3 fatty acids; polyunsaturated fatty acids; protein content; scopolamine; therapeutics;     Show all 17 Subjects
Abstract:
... Omega-3 polyunsaturated fatty acids (PUFA) are critical for optimal brain health and are involved in psychiatric and neurological ailments. Here, we report the effects of higher endogenous omega-3 PUFA on memory impairment in the hippocampus by studying mice with transgenic expression of the fat-1 gene that converts omega-6 to omega-3 PUFA. We performed Y-maze and passive avoidance tests to evalua ...
DOI:
10.1016/j.jnutbio.2020.108394

18. Immune and physiological responses of mud crab (Scylla paramamosain) under air exposure

Author:
Cheng, Chang-Hong; Ma, Hong-Ling; Deng, Yi-Qin; Feng, Juan; Jie, Yu-Kun; Guo, Zhi-Xun
Source:
Comparative biochemistry and physiology 2020 v.233 pp. 108767
ISSN:
1532-0456
Subject:
caspase-3,   etc   ; Scylla paramamosain; alanine transaminase; aspartate transaminase; catalase; crabs; enzyme activity; glucose; hypoxia-inducible factor 1; malondialdehyde; oxidative stress; physiological response; signal transduction; superoxide dismutase;     Show all 14 Subjects
Abstract:
... The immune and physiological responses of mud crab (Scylla paramamosain) under air exposure were studied. The results showed that air exposure increased plasma activities of AST, ALT, ALP. There was a significant increase in glucose (GLU) and malondialdehyde (MDA) levels after air exposure. The transcript levels of SOD, CAT, HSP90, HSP70, p53, and hypoxia-inducible factor-1 (HIF-1) were induced by ...
DOI:
10.1016/j.cbpc.2020.108767

19. rLj-RGD4, the shortened peptide of rLj-RGD3 from Lampetra japonica, protects against cerebral ischemia/reperfusion injury via the PI3K/Akt pathway

Author:
Jia, Qilan; Zhang, Xin; Zhang, Ailin; Wu, Rui; Liu, Zhien; Chen, Yiheng; Wang, Jihong; Lv, Li
Source:
Peptides 2020 v.129 pp. 170310
ISSN:
0196-9781
Subject:
caspase-3,   etc   ; Lethenteron camtschaticum; apoptosis; brain; infarction; ischemia; mutants; peptides; phosphatidylinositol 3-kinase; protective effect; rats; reperfusion injury; salivary glands; stroke; survival rate; toxicity;     Show all 16 Subjects
Abstract:
... The toxic RGD peptide, rLj-RGD4, characterized by 4 (Arg-Gly-Asp) (RGD) motifs, is a novel mutant of rLj-RGD3 from the salivary gland of Lampetra japonica. Our previous study showd that rLj-RGD3 exerts a protective effect against cerebral ischemia injury in rats. Through the induction of middle cerebral artery occlusion/reperfusion (MCAO) injuries in rats, the present study investigated the effect ...
DOI:
10.1016/j.peptides.2020.170310

20. 1,25-Dihydroxyvitamin D attenuates diabetic cardiac autophagy and damage by vitamin D receptor-mediated suppression of FoxO1 translocation

Author:
Guo, Xiaoping; Lin, Hongkun; Liu, Jingjing; Wang, Dongxia; Li, Dan; Jiang, Chunjie; Tang, Yuhan; Wang, Jun; Zhang, Tingrui; Li, Yanyan; Yao, Ping
Source:
The Journal of nutritional biochemistry 2020 v.80 pp. 108380
ISSN:
0955-2863
Subject:
caspase-3,   etc   ; agonists; antagonists; autophagy; blood glucose; calcitriol receptors; cardiomyocytes; chloroquine; diabetes; fasting; glucose; glucose tolerance tests; hydroxycholecalciferols; rapamycin; rats; small interfering RNA; transcription (genetics); transcription factors;     Show all 18 Subjects
Abstract:
... Cardiovascular abnormalities are one of the most important complications associated with diabetes. However, the effect of 1, 25-dihydroxyvitamin D (1,25D) on the diabetic heart and the associated regulatory mechanisms are not well appreciated. Here, we report that activation of the vitamin D receptor (VDR) by 1,25D depresses autophagic activity by inhibiting nuclear FoxO1 translocation to attenuat ...
DOI:
10.1016/j.jnutbio.2020.108380