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1. Assemblies of bi-functional peptides on pyrolytic graphite for cell adhesion

Author:
Tatematsu, Soichiro; Ohnishi, Tomoko; Saito, Shogo; Tanaka, Masayoshi; Hayamizu, Yuhei; Okochi, Mina
Source:
Biochemical engineering journal 2021 v.170 pp. 107988
ISSN:
1369-703X
Subject:
cell adhesion,   etc   ; adhesion; electrochemistry; ferricyanides; graphene; peptides;     Show all 6 Subjects
Abstract:
... Designing cell-electrode biointerfaces is important for electrochemical monitoring of cell functions and activities in their microenvironments. Herein, peptide monolayer was constructed on the pyrolytic graphite surface by self-assembling of tritryptophane, and the bi-functionalized peptide conjugating cell adhesion peptide, GRGDS (Gly-Arg-Gly-Asp-Ser) induced adhesion of anchorage-dependent cells ...
DOI:
10.1016/j.bej.2021.107988

2. Soluble DC-SIGN isoforms: Ligands with unknown functions - A mini-review

Author:
Sales Pereira, Lailah Horácio; Alves, Amanda do Carmo; Siqueira Ferreira, Jaqueline Maria; dos Santos, Luciana Lara
Source:
Microbial pathogenesis 2021 v.150 pp. 104731
ISSN:
0882-4010
Subject:
cell adhesion,   etc   ; bacterial infections; ligands; pathogenesis;     Show all 4 Subjects
Abstract:
... The present study aimed to perform a mini-review of the complete soluble isoforms of Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin (sDC-SIGN), their functions, and their correlation with diseases. The present review reveals the lack of studies regarding these soluble isoforms and poor understanding of the importance of the topic, considering the concordant finding ...
DOI:
10.1016/j.micpath.2021.104731

3. CADM1 promotes malignant features of small-cell lung cancer by recruiting 4.1R to the plasma membrane

Author:
Funaki, Toko; Ito, Takeshi; Tanei, Zen-ichi; Goto, Akiteru; Niki, Toshiro; Matsubara, Daisuke; Murakami, Yoshinori
Source:
Biochemical and biophysical research communications 2021 v.534 pp. 172-178
ISSN:
0006-291X
Subject:
cell adhesion; cell adhesion molecules,   etc   ; agar; cell lines; epithelium; lung neoplasms; plasma membrane; protein binding; research;     Show all 9 Subjects
Abstract:
... Cell adhesion molecule 1 (CADM1), which mediates intercellular adhesion between epithelial cells, is shown to be highly expressed in small-cell lung cancer (SCLC) and to enhance tumorigenicity of SCLC cells in nude mice. Here, we investigated the molecular mechanism underlying the oncogenic role of CADM1 in SCLC. CADM1 promoted colony formation of SCLC cells in soft agar. Analysis of deletion and ...
DOI:
10.1016/j.bbrc.2020.11.121

4. A versatile click chemistry-based approach for functionalizing biomaterials of diverse nature with bioactive peptides

Author:
Martin-Gómez, Helena; Oliver-Cervelló, Lluís; Sánchez-Campillo, Iván; Marchán, Vicente; Ginebra, Maria-Pau; Mas-Moruno, Carlos
Source:
Chemical communications 2021 v.57 no.8 pp. 982-985
ISSN:
1364-548X
Subject:
cell adhesion,   etc   ; biocompatible materials; gold; peptides; polylactic acid; titanium;     Show all 6 Subjects
Abstract:
... A novel and versatile toolkit approach for the functionalization of biomaterials of different nature is described. This methodology is based on the solid-phase conjugation of specific anchoring units onto a resin-bound azido-functionalized peptide by using click chemistry. A synergistic multifunctional peptidic scaffold with cell adhesive properties was used as a model compound to showcase the ver ...
DOI:
10.1039/d0cc07463b

5. An evolutionarily conserved charged residue dictates the specificity of heterophilic interactions among nectins

Author:
Duraivelan, Kheerthana; Dash, Sagarika; Samanta, Dibyendu
Source:
Biochemical and biophysical research communications 2021 v.534 pp. 504-510
ISSN:
0006-291X
Subject:
cell adhesion,   etc   ; computer simulation; glycoproteins; immunoglobulins; morphogenesis; research;     Show all 6 Subjects
Abstract:
... Nectins are a family of four cell surface glycoproteins belonging to the immunoglobulin superfamily that mediate cell-cell adhesion and associated signalling pathways, thereby regulating several physiological processes including morphogenesis, growth and development of multicellular organisms. Nectins interact among themselves through their extracellular domains from the adjacent cells in both hom ...
DOI:
10.1016/j.bbrc.2020.11.052

6. Calibration for Computer Experiments With Binary Responses and Application to Cell Adhesion Study

Author:
Sung, Chih-Li; Hung, Ying; Rittase, William; Zhu, Cheng; Wu, C. F. J.
Source:
Journal of the American Statistical Association 2020 v.115 no.532 pp. 1664-1674
ISSN:
1537-274X
Subject:
cell adhesion,   etc   ; T-lymphocytes; computers;     Show all 3 Subjects
Abstract:
... Calibration refers to the estimation of unknown parameters which are present in computer experiments but not available in physical experiments. An accurate estimation of these parameters is important because it provides a scientific understanding of the underlying system which is not available in physical experiments. Most of the work in the literature is limited to the analysis of continuous resp ...
DOI:
10.1080/01621459.2019.1699419

7. Variations in N-linked glycosylation of glycosylation-dependent cell adhesion molecule 1 (GlyCAM-1) whey protein: Intercow differences and dietary effects

Author:
Valk-Weeber, Rivca L.; Nichols, Kelly; Dijkhuizen, Lubbert; Bijl, Etske; van Leeuwen, Sander S.
Source:
Journal of dairy science 2021 v.104 no.4 pp. 5056-5068
ISSN:
0022-0302
Subject:
cell adhesion; cell adhesion molecules,   etc   ; Holstein; cows; dietary supplements; early lactation; glucose; glycoproteins; glycosylation; immune system; lactoferrin; milk; palm oils; polysaccharides; whey; whey protein;     Show all 16 Subjects
Abstract:
... In bovine milk serum, the whey proteins with the highest N-glycan contribution are lactoferrin, IgG, and glycosylation-dependent cellular adhesion molecule 1 (GlyCAM-1); GlyCAM-1 is the dominant N-linked glycoprotein in bovine whey protein products. Whey proteins are base ingredients in a range of food products, including infant formulas. Glycan monosaccharide composition and variation thereof may ...
DOI:
10.3168/jds.2020-19297

8. Tea Catechin Inhibits Biofilm Formation of Methicillin-Resistant S. aureus

Author:
Zhao, Yanying; Qu, Yun; Tang, Junni; Chen, Juan; Liu, Ji
Source:
Journal of food quality 2021 v.2021
ISSN:
1745-4557
Subject:
cell adhesion; cell adhesion molecules,   etc   ; adhesins; antibiotic resistance; biofilm; catechin; colorimetry; dose response; fibronectins; food quality; methicillin-resistant Staphylococcus aureus; minimum inhibitory concentration; pathogens; public health; tea;     Show all 15 Subjects
Abstract:
... Staphylococcus aureus (S. aureus) is the most common pathogen causing infections from skin to systemic infections. The success of S. aureus infections can partially be attributed to its antibiotic resistance and to its ability to form biofilm. An increasing prevalence of methicillin-resistant S. aureus (MRSA) becomes a global public health problem in recent decades. Here, the effects of tea catech ...
DOI:
10.1155/2021/8873091

9. Silk fibroin H-fibroin/poly(ε-caprolactone) core-shell nanofibers with enhanced mechanical property and long-term drug release

Author:
Wang, Zengkai; Song, Xiaolu; Cui, Yanhua; Cheng, Kai; Tian, Xiaohua; Dong, Mingdong; Liu, Lei
Source:
Journal of colloid and interface science 2021 v.593 pp. 142-151
ISSN:
0021-9797
Subject:
cell adhesion,   etc   ; biocompatibility; biodegradability; drugs; emulsions; ethanol; fibroins; mechanical properties; nanofibers; prophase; transmission electron microscopy;     Show all 11 Subjects
Abstract:
... The scaffold materials with good mechanical and structural properties, controlled drug release performance, biocompatibility and biodegradability are important tenet in tissue engineering. In this work, the functional core–shell nanofibers with poly(ε-caprolactone) (PCL) as shell and silk fibroin heavy chain (H-fibroin) as core were constructed by emulsion electrospinning. The transmission electro ...
DOI:
10.1016/j.jcis.2021.02.099

10. Nr4a1 promotes cell adhesion and fusion by regulating Zeb1 transcript levels in myoblasts

Author:
Liu, Yixuan; Liu, Nanqi; Yu, Yang; Wang, Difei
Source:
Biochemical and biophysical research communications 2021 v.556 pp. 127-133
ISSN:
0006-291X
Subject:
cell adhesion,   etc   ; adhesion; cadherins; integrins; muscle development; muscle tissues; muscles; myoblasts; research; zinc finger motif;     Show all 10 Subjects
Abstract:
... Nuclear receptor subfamily 4 group A member 1 (NR4A1) acts as a myogenic factor in muscle development and regeneration; however, it remains unclear how Nr4a1 regulates myoblast physiology. In this study, report a role for Nr4a1-mediated regulation of cell adhesion in myoblast and muscle tissue. Nr4a1-overexpression myoblast, Nr4a1-konckdown myoblast and mice gastrocnemius muscle following an injec ...
DOI:
10.1016/j.bbrc.2021.03.153

11. LINC00176 facilitates CD4+T cell adhesion in systemic lupus erythematosus via the WNT5a signaling pathway by regulating WIF1

Author:
Lu, Chang; Shao, Xue; Zhou, Shengzhu; Pan, Chenyu
Source:
Molecular immunology 2021 v.134 pp. 202-209
ISSN:
0161-5890
Subject:
cell adhesion,   etc   ; adhesion; genes; immunology; loss-of-function mutation; lupus erythematosus; therapeutics;     Show all 7 Subjects
Abstract:
... Accruing research shows the implications of long non-coding RNAs (lncRNAs) in the progression of various autoimmune diseases including systemic lupus erythematosus (SLE). The present study aimed to identify the expression pattern of LINC00176 in SLE and to explore its effects on CD4⁺T cell adhesion in this context. The biological functions of LINC00176, WIF1 and WNT5a on CD4⁺T cells in SLE were ev ...
DOI:
10.1016/j.molimm.2021.02.018

12. Inactivation of Lats1 and Lats2 highlights the role of hippo pathway effector YAP in larynx and vocal fold epithelium morphogenesis

Author:
Mohad, Vidisha; Lungova, Vlasta; Verheyden, Jamie; Thibeault, Susan L.
Source:
Developmental biology 2021 v.473 pp. 33-49
ISSN:
0012-1606
Subject:
cell adhesion,   etc   ; basement membrane; cartilage; embryogenesis; larynx; mice; morphogenesis; muscle development;     Show all 8 Subjects
Abstract:
... Proliferation and differentiation of vocal fold epithelial cells during embryonic development is poorly understood. We examined the role of Hippo signaling, a vital pathway known for regulating organ size, in murine laryngeal development. Conditional inactivation of the Hippo kinase genes Lats1 and Lats2, specifically in vocal fold epithelial cells, resulted in severe morphogenetic defects. Deleti ...
DOI:
10.1016/j.ydbio.2021.01.012

13. Large fuzzy biodegradable polyester microspheres with dopamine deposition enhance cell adhesion and bone regeneration in vivo

Author:
Zhang, Deteng; Zheng, Honghao; Geng, Keyu; Shen, Jianhua; Feng, Xue; Xu, Peifang; Duan, Yiyuan; Li, Yifan; Wu, Ronghuan; Gou, Zhongru; Gao, Changyou
Source:
Biomaterials 2021 v.272 pp. 120783
ISSN:
0142-9612
Subject:
cell adhesion,   etc   ; biocompatible materials; biodegradability; dopamine; emulsions; histology; micro-computed tomography; microparticles; polyesters; surgery; tissue repair;     Show all 11 Subjects
Abstract:
... The biodegradable polymer microparticles with different surface morphology and chemical compositions may influence significantly the behaviors of cells, and thereby further the performance of tissue regeneration in vivo. In this study, multi-stage hierarchical textures of poly(D,L-lactic-co-glycolide) (PLGA)/PLGA-b-PEG (poly(ethylene glycol)) microspheres with a diameter as large as 50–100 μm are ...
DOI:
10.1016/j.biomaterials.2021.120783

14. Micropattern-controlled chirality of focal adhesions regulates the cytoskeletal arrangement and gene transfection of mesenchymal stem cells

Author:
Wang, Yongtao; Yang, Yingjun; Wang, Xinlong; Yoshitomi, Toru; Kawazoe, Naoki; Yang, Yingnan; Chen, Guoping
Source:
Biomaterials 2021 v.271 pp. 120751
ISSN:
0142-9612
Subject:
cell adhesion,   etc   ; DNA replication; adhesion; biocompatible materials; cytoskeleton; fibronectins; genes; humans; mechanics; optical isomerism; polystyrenes; transfection;     Show all 12 Subjects
Abstract:
... Cell chirality has been demonstrated to be important for controlling cell functions. However, it is not clear how the chirality of the extracellular microenvironment regulates cell adhesion and cytoskeletal structures and therefore affects gene transfection. In this study, the chirality of focal adhesions and the cytoskeleton of single human mesenchymal stem cells (hMSCs) was controlled by special ...
DOI:
10.1016/j.biomaterials.2021.120751

15. Analysis of the behavior of 2D monolayers and 3D spheroid human pancreatic beta cells derived from induced pluripotent stem cells in a microfluidic environment

Author:
Essaouiba, Amal; Jellali, Rachid; Shinohara, Marie; Scheidecker, Benedikt; Legallais, Cécile; Sakai, Yasuyuki; Leclerc, Eric
Source:
Journal of biotechnology 2021 v.330 pp. 45-56
ISSN:
0168-1656
Subject:
cell adhesion,   etc   ; biotechnology; c-peptide; diabetes; extracellular matrix; glucagon; glucose; humans; hypoglycemic agents; insulin secretion; models;     Show all 11 Subjects
Abstract:
... The limited availability of primary human β-cells/islets and their quality (due to donor diversity) restrict the development of in vitro models for diabetes research. Human induced pluripotent stem cells (hiPSCs) may be a promising cell-source for diabetes studies, anti-diabetic drug screening and personalized therapies. However, achieving levels of maturity/functionality that are comparable to th ...
DOI:
10.1016/j.jbiotec.2021.02.009

16. Dexmedetomidine inhibits cell malignancy in osteosarcoma cells via miR-520a-3p-YOD1 interactome

Author:
Yan, Rongrong; Jin, Shuangfen; Liu, Hongchao; Le, Chengjin; Gao, Jie; Cheng, Jing; Chen, Lin; Li, Na
Source:
Biochemical and biophysical research communications 2021 v.543 pp. 56-64
ISSN:
0006-291X
Subject:
cell adhesion,   etc   ; adhesion; apoptosis; cell viability; dexmedetomidine; osteosarcoma; research; surgery; survival rate;     Show all 9 Subjects
Abstract:
... Osteosarcoma is a common malignant tumor in adolescents with a low 5-year survival rate. Dexmedetomidine (DEX) has been widely used for surgery of osteosarcoma patients. MiR-520a-3p and YOD1 expression was abnormal in osteosarcoma cells. However, whether DEX affects osteosarcoma progression via miR-520a-3p-YOD1 interactome needs to be explored.We detected osteosarcoma cells biological behavior by ...
DOI:
10.1016/j.bbrc.2021.01.045

17. Influence of poly(N-isopropylacrylamide) (PIPAAm) graft density on properties of PIPAAm grafted poly(dimethylsiloxane) surfaces and their stability

Author:
Akiyama, Yoshikatsu
Source:
Heliyon 2021 v.7 no.3 pp. e06520
ISSN:
2405-8440
Subject:
cell adhesion,   etc   ; cell culture; contact angle; crosslinking; denaturation; fibronectins; gels; hydrophobicity; irradiation; temperature;     Show all 10 Subjects
Abstract:
... A previous report shows that poly(N-isopropylacrylamide) (PIPAAm) gel grafted onto poly(dimethylsiloxane) (PDMS) (PI-PDMS) surfaces with large PIPAAm graft density (Lar-PI-PDMS), is prepared by using electron beam irradiation, demonstrating that applied mechanical stretching affects properties of the Lar-PI-PDMS surface. However, the influence of PIPAAm graft density on the properties of PI-PDMS s ...
DOI:
10.1016/j.heliyon.2021.e06520

18. Integrin α11β1 is a receptor for collagen XIII

Author:
Koivunen, Jarkko; Tu, Hongmin; Kemppainen, Antti; Anbazhagan, Padmanabhan; Finnilä, Mikko A.; Saarakkala, Simo; Käpylä, Jarmo; Lu, Ning; Heikkinen, Anne; Juffer, André H.; Heino, Jyrki; Gullberg, Donald; Pihlajaniemi, Taina
Source:
Cell and tissue research 2021 v.383 no.3 pp. 1135-1153
ISSN:
0302-766X
Subject:
cell adhesion,   etc   ; collagen; homeostasis; integrins; mice; micro-computed tomography; mutants; osteoporosis; phenotype; research; surface plasmon resonance;     Show all 11 Subjects
Abstract:
... Collagen XIII is a conserved transmembrane collagen mainly expressed in mesenchymal tissues. Previously, we have shown that collagen XIII modulates tissue development and homeostasis. Integrins are a family of receptors that mediate signals from the environment into the cells and vice versa. Integrin α11β1 is a collagen receptor known to recognize the GFOGER (O=hydroxyproline) sequence in collagen ...
DOI:
10.1007/s00441-020-03300-y

19. L- theanine suppresses the metastasis of prostate cancer by downregulating MMP9 and Snail

Author:
Fan, Xirui; Zhou, Jinyi; Bi, Xiaowen; Liang, Juanjuan; Lu, Shuai; Yan, Xintong; Luo, Lan; Yin, Zhimin
Source:
The Journal of nutritional biochemistry 2021 v.89 pp. 108556
ISSN:
0955-2863
Subject:
cell adhesion,   etc   ; ; anticarcinogenic agents; apoptosis; cadherins; green tea; metastasis; nonprotein amino acids; prostatic neoplasms; therapeutics; vimentin;     Show all 11 Subjects
Abstract:
... Prostate cancer (PCa) is a very prevalent male-specific malignancy; most PCa patients eventually die as a result of metastasis. L-theanine (C7H14N2O3), a nonprotein amino acid derivative from green tea leaves, has been demonstrated to act as an anticarcinogen through proapoptotic and antiproliferative effects. However, the antimetastatic effect of L-theanine in tumor cells and its underlying mecha ...
DOI:
10.1016/j.jnutbio.2020.108556

20. Oral bacteria and leaky endothelial junctions in remote extraoral sites

Author:
Hajishengallis, George
Source:
TheFEBS journal 2021 v.288 no.5 pp. 1475-1478
ISSN:
1742-464X
Subject:
cell adhesion,   etc   ; ; Danio rerio; Porphyromonas gingivalis; cadherins; cardiovascular diseases; endothelial cells; gingipain; models; pathogens; periodontitis; permeability;     Show all 12 Subjects
Abstract:
... Periodontitis and periodontal pathogens have been associated with systemic complications that influence comorbid conditions, such as cardiovascular disease. Using a zebrafish larvae infection model, Farrugia et al. show that Porphyromonas gingivalis causes vascular damage and increased endothelial permeability by degrading, via its gingipain proteases, platelet endothelial cell adhesion molecule‐1 ...
DOI:
10.1111/febs.15510