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1. Microfluidic deformability cytometry: A review

Author:
Yao Chen; Kefan Guo; Lin Jiang; Shu Zhu; Zhonghua Ni; Nan Xiang
Source:
Talanta 2023 v.251 pp. 123815
ISSN:
0039-9140
Subject:
cell cycle,   etc   ; acoustics; cell growth; disease diagnosis; drugs; extrusion; hydrodynamics; medicine; microfluidic technology;     Show all 9 Subjects
Abstract:
... Cell deformability plays an important role in cellular processes and functions, including cell growth and differentiation, as well as cell transfer and cell cycle. Measuring deformability at the single-cell level has attracted great interest in biomedicine owing to its importance in various applications, such as cell separation, disease diagnosis, and drug screening. Therefore, an accurate, robust ...
DOI:
10.1016/j.talanta.2022.123815

2. Traditional Chinese Medicine has great potential as candidate drugs for lung cancer: A review

Author:
Zhicheng Wei; Jing Chen; Fang Zuo; Julie Guo; Xiaodong Sun; Deming Liu; Conghai Liu
Source:
Journal of ethnopharmacology 2023 v.300 pp. 115748
ISSN:
0378-8741
Subject:
cell cycle,   etc   ; Oriental traditional medicine; apoptosis; autophagy; chemical structure; cytotoxicity; drug resistance; drug therapy; flavonoids; human health; lung neoplasms; metastasis; morbidity; mortality; neoplasm cells; polyphenols; terpenoids; Europe;     Show all 18 Subjects
Abstract:
... With high mortality and morbidity rates, lung cancer (LC) has become one of the major threats to human health. The treatment strategies for LC currently face issues, such as drug resistance and body tolerance. Traditional Chinese medicine (TCM) is characterized by novel pharmacological mechanisms, low toxicity, and limited side effects. TCM includes a substantial number of biologically active ingr ...
DOI:
10.1016/j.jep.2022.115748

3. Systematic mapping of nuclear domain-associated transcripts reveals speckles and lamina as hubs of functionally distinct retained introns

Author:
A. Rasim Barutcu; Mingkun Wu; Ulrich Braunschweig; Boris J.A. Dyakov; Zheng Luo; Kyle M. Turner; Tanja Durbic; Zhen-Yuan Lin; Robert J. Weatheritt; Philipp G. Maass; Anne-Claude Gingras; Benjamin J. Blencowe
Source:
Molecular cell 2022 v.82 no.5 pp. 1035-1052.e9
ISSN:
1097-2765
Subject:
cell cycle,   etc   ; humans; introns;     Show all 3 Subjects
Abstract:
... The nucleus is highly compartmentalized through the formation of distinct classes of membraneless domains. However, the composition and function of many of these structures are not well understood. Using APEX2-mediated proximity labeling and RNA sequencing, we surveyed human transcripts associated with nuclear speckles, several additional domains, and the lamina. Remarkably, speckles and lamina ar ...
DOI:
10.1016/j.molcel.2021.12.010

4. Chromatin-bound RB targets promoters, enhancers, and CTCF-bound loci and is redistributed by cell-cycle progression

Author:
Ioannis Sanidas; Hanjun Lee; Purva H. Rumde; Gaylor Boulay; Robert Morris; Gabriel Golczer; Marcelo Stanzione; Soroush Hajizadeh; Jun Zhong; Meagan B. Ryan; Ryan B. Corcoran; Benjamin J. Drapkin; Miguel N. Rivera; Nicholas J. Dyson; Michael S. Lawrence
Source:
Molecular cell 2022 v.82 no.18 pp. 3333-3349.e9
ISSN:
1097-2765
Subject:
cell cycle,   etc   ; chromatin; phosphorylation;     Show all 3 Subjects
Abstract:
... The interaction of RB with chromatin is key to understanding its molecular functions. Here, for first time, we identify the full spectrum of chromatin-bound RB. Rather than exclusively binding promoters, as is often described, RB targets three fundamentally different types of loci (promoters, enhancers, and insulators), which are largely distinguishable by the mutually exclusive presence of E2F1, ...
DOI:
10.1016/j.molcel.2022.07.014

5. Proliferation maintains the undifferentiated status of stem cells: The role of the planarian cell cycle regulator Cdh1

Author:
Yuki Sato; Yoshihiko Umesono; Yoshihito Kuroki; Kiyokazu Agata; Chikara Hashimoto
Source:
Developmental biology 2022 v.482 pp. 55-66
ISSN:
0012-1606
Subject:
cell cycle,   etc   ; Dugesia; homeostasis;     Show all 3 Subjects
Abstract:
... The coincidence of cell cycle exit and differentiation has been described in a wide variety of stem cells and organisms for decades, but the causal relationship is still unclear due to the complicated regulation of the cell cycle. Here, we used the planarian Dugesia japonica since they may possess a simple cell cycle regulation in which Cdh1 is one of the factors responsible for exiting the cell c ...
DOI:
10.1016/j.ydbio.2021.12.006

6. A photo-activated aptamer–drug conjugate for targeted drug delivery

Author:
Jing Liu; Xiangjun Liu; Mengwen Yi; Yue Sun; Tao Bing; Nan Zhang; Dihua Shangguan
Source:
Chemical communications 2022 v.58 no.77 pp. 10797-10800
ISSN:
1364-548X
Subject:
cell cycle,   etc   ; cytotoxicity; drugs; oligonucleotides;     Show all 4 Subjects
Abstract:
... A photo-activated aptamer–drug conjugate, HG1-9–DNP, was developed based on an aptamer HG1-9 and a photolabile naphthalimide derivative DNP. HG1-9–DNP could be internalized into cells mediated by TfR, then photocleaved, and released a promising cytotoxic agent, DNNH, which arrested the cell cycle at the G2/M phase, resulting in high photo-induced cytotoxicity. ...
DOI:
10.1039/d2cc04045j

7. scDART-seq reveals distinct m6A signatures and mRNA methylation heterogeneity in single cells

Author:
Matthew Tegowski; Mathieu N. Flamand; Kate D. Meyer
Source:
Molecular cell 2022 v.82 no.4 pp. 868-878.e10
ISSN:
1097-2765
Subject:
cell cycle,   etc   ; gene expression; methylation;     Show all 3 Subjects
Abstract:
... N⁶-methyladenosine (m⁶A) is an abundant RNA modification that plays critical roles in RNA regulation and cellular function. Global m⁶A profiling has revealed important aspects of m⁶A distribution and function, but to date such studies have been restricted to large populations of cells. Here, we develop a method to identify m⁶A sites transcriptome-wide in single cells. We uncover surprising heterog ...
DOI:
10.1016/j.molcel.2021.12.038

8. Proteolytic control in ciliogenesis: Temporal restriction or early initiation?

Author:
Gregor Habeck; Jörg Schweiggert
Source:
BioEssays 2022 v.44 no.9 pp. e2200087
ISSN:
0265-9247
Subject:
cell cycle,   etc   ; biogenesis; centrosomes; proteolysis; proteome;     Show all 5 Subjects
Abstract:
... Cellular processes are highly dependent on a dynamic proteome that undergoes structural and functional rearrangements to allow swift conversion between different cellular states. By inducing proteasomal degradation of inhibitory or stimulating factors, ubiquitylation is particularly well suited to trigger such transitions. One prominent example is the remodelling of the centrosome upon cell cycle ...
DOI:
10.1002/bies.202200087

9. Cell cycle-dependent endocytosis of DNA-wrapped single-walled carbon nanotubes by neural progenitor cells

Author:
Swetha Chandrasekar; Sophia Kuipa; Ana I. Vargas; Tetyana Ignatova; Slava V. Rotkin; Sabrina S. Jedlicka
Source:
Biophysical reports 2022 v.2 no.3 pp. 100061
ISSN:
2667-0747
Subject:
cell cycle checkpoints,   etc   ; DNA; carbon nanotubes; endocytosis;     Show all 4 Subjects
Abstract:
... While exposure of C17.2 neural progenitor cells (NPCs) to nanomolar concentrations of carbon nanotubes (NTs) yields evidence of cellular substructure reorganization and alteration of cell division and differentiation, the mechanisms of NT entry are not understood. This study examines the entry modes of (GT)₂₀ DNA-wrapped single-walled carbon nanotubes (SWCNTs) into NPCs. Several endocytic mechanis ...
DOI:
10.1016/j.bpr.2022.100061

10. Pan-cancer analysis of biological events on cell cycle instability in gastrointestinal cancers with integrative scoring method

Author:
Sayyed Sajjad Moravveji; Samane Khoshbakht; Majid Mokhtari; Mahdieh Salimi; Ali Masoudi-Nejad
Source:
Genomics 2022 v.114 no.1 pp. 253-265
ISSN:
0888-7543
Subject:
cell cycle,   etc   ; epigenetics; gastrointestinal system; genomics; transcriptomics;     Show all 5 Subjects
Abstract:
... Omics data integration plays an essential role in manifesting hidden cancer insights. To detect the main combinatorial/parallel impact of cancer events, integrative approaches in pan-cancer studies must be used. Here, we assessed gastrointestinal (GI) cancers from several perspectives of genomics, transcriptomics, epigenomics, and also combinatorial impacts using a novel integrative approach to sc ...
DOI:
10.1016/j.ygeno.2021.12.005

11. Significance of lncRNA abundance to function

Author:
Ioannis Grammatikakis; Ashish Lal
Source:
Mammalian genome 2022 v.33 no.2 pp. 271-280
ISSN:
0938-8990
Subject:
cell cycle,   etc   ; gene expression; genome; homeostasis; mammals;     Show all 5 Subjects
Abstract:
... Long noncoding RNAs (lncRNAs) have emerged as regulators of diverse cellular processes. Although the vast majority of lncRNAs are expressed at lower levels compared to messenger RNAs (mRNAs), many lncRNAs play a central role in the regulation of cellular homeostasis and gene expression. With the advancement of next generation sequencing technologies, recent studies illustrate the diversity of lncR ...
DOI:
10.1007/s00335-021-09901-4

12. The TRESLIN-MTBP complex couples completion of DNA replication with S/G2 transition

Author:
Gijs Zonderland; Riccardo Vanzo; Sampath Amitash; Elena Martín-Doncel; Fabian Coscia; Andreas Mund; Mads Lerdrup; Jan Benada; Dominik Boos; Luis Toledo
Source:
Molecular cell 2022 v.82 no.18 pp. 3350-3365.e7
ISSN:
1097-2765
Subject:
cell cycle,   etc   ; DNA replication; models; phosphotransferases (kinases);     Show all 4 Subjects
Abstract:
... It has been proposed that ATR kinase senses the completion of DNA replication to initiate the S/G2 transition. In contrast to this model, we show here that the TRESLIN-MTBP complex prevents a premature entry into G2 from early S-phase independently of ATR/CHK1 kinases. TRESLIN-MTBP acts transiently at pre-replication complexes (preRCs) to initiate origin firing and is released after the subsequent ...
DOI:
10.1016/j.molcel.2022.08.006

13. Dynamical modeling for non-Gaussian data with high-dimensional sparse ordinary differential equations

Author:
Muye Nanshan; Nan Zhang; Xiaolei Xun; Jiguo Cao
Source:
Computational statistics & data analysis 2022 v.173 pp. 107483
ISSN:
0167-9473
Subject:
cell cycle,   etc   ; data analysis; data collection; stock exchange; yeasts;     Show all 5 Subjects
Abstract:
... Ordinary differential equations (ODE) have been widely used for modeling dynamical complex systems. For high-dimensional ODE models where the number of differential equations is large, it remains challenging to estimate the ODE parameters and to identify the sparse structure of the ODE models. Most existing methods exploit the least-square based approach and are only applicable to Gaussian observa ...
DOI:
10.1016/j.csda.2022.107483

14. Understanding the interaction of 14‐3‐3 proteins with hDMX and hDM2: a structural and biophysical study

Author:
Sonja Srdanović; Madita Wolter; Chi H. Trinh; Christian Ottmann; Stuart L. Warriner; Andrew J. Wilson
Source:
FEBS journal 2022 v.289 no.17 pp. 5341-5358
ISSN:
1742-464X
Subject:
cell cycle checkpoints,   etc   ; DNA repair; apoptosis; peptides; phosphorylation; stabilizers;     Show all 6 Subjects
Abstract:
... p53 plays a critical role in regulating diverse biological processes: DNA repair, cell cycle arrest, apoptosis and senescence. The p53 pathway has therefore served as the focus of multiple drug‐discovery efforts. p53 is negatively regulated by hDMX and hDM2; prior studies have identified 14‐3‐3 proteins as hDMX and hDM2 client proteins. 14‐3‐3 proteins are adaptor proteins that modulate localizati ...
DOI:
10.1111/febs.16433

15. Spheroid culture models adequately imitate distinctive features of the renal cancer or melanoma microenvironment

Author:
Aleksandra Filipiak-Duliban; Klaudia Brodaczewska; Aleksandra Majewska; Claudine Kieda
Source:
In vitro cellular & developmental biology 2022 v.58 no.5 pp. 349-364
ISSN:
1071-2690
Subject:
cell cycle checkpoints,   etc   ; epithelium; hypoxia; kidney neoplasms; kidneys; melanoma; models;     Show all 7 Subjects
Abstract:
... Tumor development studies should adapt to cancer cells’ specific mechanisms in connection with their microenvironment. Standard two-dimensional cultures and gas composition are not relevant to the real cancer environment. Existing three-dimensional models are often requiring sophisticated conditions. Here, we propose and characterize, in two cancer models, melanoma (B16F10) and kidney cancer (RenC ...
DOI:
10.1007/s11626-022-00685-8

16. TOR signaling is the potential core of conserved regulation of trichome development in plant

Author:
Lan Yu; Haoran Wang; Hongyun Xing; Qi Ding; Xiaoyu Wang; Pengpeng Hu; Xiangnan Meng; Haiyan Fan; Yang Yu; Na Cui
Source:
Acta physiologiae plantarum 2022 v.44 no.10 pp. 95
ISSN:
0137-5881
Subject:
cell cycle,   etc   ; Arabidopsis; biotic stress; chemical defenses; morphogenesis; tomatoes; trichomes;     Show all 7 Subjects
Abstract:
... The function of trichome in plants, the first barrier against biotic stress and changing environments, is irreplaceable in physical protection and chemical defense. The regulation processing developments of trichome in plants can be divided into two categories: the single-celled trichome exampled by Arabidopsis and multicellular trichome exampled by tomato. This paper focuses on the types, morphog ...
DOI:
10.1007/s11738-022-03433-3

17. H2A.Z's ‘social’ network: functional partners of an enigmatic histone variant

Author:
Carlotta Kreienbaum; Lena W. Paasche; Sandra B. Hake
Source:
Trends in biochemical sciences 2022 pp. -
ISSN:
0968-0004
Subject:
cell cycle,   etc   ; carcinogenesis; chromatin; gene activation; gene expression; histones; vertebrates;     Show all 7 Subjects
Abstract:
... The histone variant H2A.Z has been extensively studied to understand its manifold DNA-based functions. In the past years, researchers identified its specific binding partners, the ‘H2A.Z interactome’, that convey H2A.Z-dependent chromatin changes. Here, we summarize the latest findings regarding vertebrate H2A.Z-associated factors and focus on their roles in gene activation and repression, cell cy ...
DOI:
10.1016/j.tibs.2022.04.014

18. The Dual Role of Mesenchymal Stromal Cells and Their Extracellular Vesicles in Carcinogenesis

Author:
Zarema Gilazieva; Aleksei Ponomarev; Albert Rizvanov; Valeriya Solovyeva
Source:
Biology 2022 v.11 no.6 pp. -
ISSN:
2079-7737
Subject:
cell cycle,   etc   ; angiogenesis; apoptosis; carcinogenesis; extracellular matrix; neoplasm progression; neoplasms;     Show all 7 Subjects
Abstract:
... Mesenchymal stem cells (MSCs) are a major component of the tumor microenvironment (TME) and play an important role in tumor progression. MSCs remodel the extracellular matrix, participate in the epithelial–mesenchymal transition, promote the spread of metastases, and inhibit antitumor immune responses in the TME; however, there are also data pertaining to the antitumor effects of MSCs. MSCs activa ...
DOI:
10.3390/biology11060813

19. The cyclin‐dependent kinase inhibitor p27Kip1 interacts with the aryl hydrocarbon receptor and negatively regulates its transcriptional activity

Author:
Daniel J. Elson; Bach D. Nguyen; Rhand Wood; Yi Zhang; Veronica Puig‐Sanvicens; Siva K. Kolluri
Source:
FEBS letters 2022 v.596 no.16 pp. 2056-2071
ISSN:
0014-5793
Subject:
cell cycle,   etc   ; aryl hydrocarbon receptors; cyclin-dependent kinase; transcription (genetics);     Show all 4 Subjects
Abstract:
... p27ᴷⁱᵖ¹ functions to coordinate cell cycle progression through the inhibition of cyclin‐dependent kinase (CDK) complexes. p27ᴷⁱᵖ¹ also exerts distinct activities beyond CDK‐inhibition, including functioning as a transcriptional regulator. The aryl hydrocarbon receptor (AhR) is a ligand‐activated transcription factor with diverse biological roles. The regulatory inputs that control AhR‐mediated tra ...
DOI:
10.1002/1873-3468.14434

20. Evolutionary bioenergetics of ciliates

Author:
Michael Lynch; Paul E. Schavemaker; Timothy J. Licknack; Yue Hao; Arianna Pezzano
Source:
journal of eukaryotic microbiology 2022 v.69 no.5 pp. e12934
ISSN:
1066-5234
Subject:
cell cycle,   etc   ; Ciliophora; energy metabolism; genome; microbiology; osmoregulation; phenotype; phylogeny; ribosomes;     Show all 9 Subjects
Abstract:
... Understanding why various organisms evolve alternative ways of living requires information on both the fitness advantages of phenotypic modifications and the costs of constructing and operating cellular features. Although the former has been the subject of a myriad of ecological studies, almost no attention has been given to how organisms allocate resources to alternative structures and functions. ...
DOI:
10.1111/jeu.12934