U.S. flag

An official website of the United States government

PubAg

Main content area

You searched for: Subject "cell growth" Remove constraint Subject: "cell growth"
Start Over

Search

13,563  Search Results

« Previous | 1 - 20 of 13,563 |
Number of results to display per page

Search Results

1. More writing: mTORC1 promotes m6A mRNA methylation

Author:
Shetty, Sunil; Hall, Michael N.
Source:
Molecular cell 2021 v.81 no.10 pp. 2057-2058
ISSN:
1097-2765
Subject:
cell growth,   etc   ; cells; methylation;     Show all 3 Subjects
Abstract:
... Cho et al. (2021) and Villa et al. (2021) demonstrate that mTORC1 stimulates m⁶A mRNA methylation via WTAP expression and SAM synthesis. Increased mRNA methylation in turn promotes cell growth by enhancing mRNA degradation or translation. ...
DOI:
10.1016/j.molcel.2021.04.020

2. Retraction: Aclarubicin regulates glioma cell growth and DNA damage through the SIRT1/PI3K/AKT signaling pathway

Author:
Fisher, Laura
Source:
RSC advances 2021 v.11 no.9 pp. 5022
ISSN:
2046-2069
Subject:
cell growth,   etc   ; DNA damage; glioma;     Show all 3 Subjects
Abstract:
... Retraction of ‘Aclarubicin regulates glioma cell growth and DNA damage through the SIRT1/PI3K/AKT signaling pathway’ by Jun-Feng Huo et al., RSC Adv., 2019, 9, 28775–28782, DOI: 10.1039/C9RA05572J. ...
DOI:
10.1039/d1ra90038b

3. G-patch domain-containing protein 4 localizes to both the nucleoli and Cajal bodies and regulates cell growth and nucleolar structure

Author:
Hirawake-Mogi, Hiroko; Thanh Nhan, Nguyen Thi; Okuwaki, Mitsuru
Source:
Biochemical and biophysical research communications 2021 v.559 pp. 99-105
ISSN:
0006-291X
Subject:
cell growth,   etc   ; RNA; cell nucleolus; research; ribosomes;     Show all 5 Subjects
Abstract:
... Ribosome formation occurs in the nucleolus through interaction with various trans-acting factors. Therefore, hundreds of nucleolar proteins have a function in ribosome formation, although the precise function of each nucleolar protein in ribosome formation is largely unclear. We have previously identified an uncharacterized protein, G-patch domain-containing protein 4 (GPATCH4 or G4), as a compone ...
DOI:
10.1016/j.bbrc.2021.04.026

4. Retraction: Long non-coding RNA PCAT1 facilitates cell growth in multiple myeloma through an MTDH-mediated AKT/β-catenin signaling pathway by sponging miR-363-3p

Author:
Fisher, Laura
Source:
RSC advances 2021 v.11 no.11 pp. 6246
ISSN:
2046-2069
Subject:
cell growth,   etc   ; myeloma; non-coding RNA;     Show all 3 Subjects
Abstract:
... Retraction of ‘Long non-coding RNA PCAT1 facilitates cell growth in multiple myeloma through an MTDH-mediated AKT/β-catenin signaling pathway by sponging miR-363-3p’ by Ying Chen et al., RSC Adv., 2019, 9, 33834–33842, DOI: 10.1039/C9RA06188F. ...
DOI:
10.1039/d1ra90071d

5. Polymer fraction including exosomes derived from Chinese hamster ovary cells promoted their growth during serum-free repeated batch culture

Author:
Takagi, Mutsumi; Jimbo, Shoichi; Oda, Tsuyoshi; Goto, Yuta; Fujiwara, Masashi
Source:
Journal of bioscience and bioengineering 2021 v.131 no.2 pp. 183-189
ISSN:
1389-1723
Subject:
cell growth,   etc   ; Cricetulus griseus; adhesion; exosomes; polymers;     Show all 5 Subjects
Abstract:
... While continuous (perfusion) culture of mammalian cells might reduce the reactor size owing to the high cell density, there is the problem of higher medium cost; however, this problem is expected to be solved by the reuse of growth-promoting components in the culture supernatant. The polymer fraction (PF, 10 kDa–220 nm) collected from the supernatant of serum-free repeated-batch culture of Chinese ...
DOI:
10.1016/j.jbiosc.2020.09.011

6. YAP and TAZ Are Not Identical Twins

Author:
Reggiani, Francesca; Gobbi, Giulia; Ciarrocchi, Alessia; Sancisi, Valentina
Source:
Trends in biochemical sciences 2021 v.46 no.2 pp. 154-168
ISSN:
0968-0004
Subject:
cell growth,   etc   ; transcription (genetics); transcription factors;     Show all 3 Subjects
Abstract:
... Yes-associated protein (YAP) and TAZ (WW domain containing transcription regulator 1, or WWTR1) are paralog transcriptional regulators, able to integrate mechanical, metabolic, and signaling inputs to regulate cell growth and differentiation during development and neoplastic progression. YAP and TAZ hold common and distinctive structural features, reflecting only partially overlapping regulatory m ...
DOI:
10.1016/j.tibs.2020.08.012

7. Compacting a synthetic yeast chromosome arm

Author:
Luo, Zhouqing; Yu, Kang; Xie, Shangqian; Monti, Marco; Schindler, Daniel; Fang, Yuan; Zhao, Shijun; Liang, Zhenzhen; Jiang, Shuangying; Luan, Meiwei; Xiao, Chuanle; Cai, Yizhi; Dai, Junbiao
Source:
Genome biology 2021 v.22 no.1 pp. 5
ISSN:
1474-760X
Subject:
cell growth,   etc   ; cell viability; chromosome aberrations; evolution; genes; yeasts;     Show all 6 Subjects
Abstract:
... BACKGROUND: Redundancy is a common feature of genomes, presumably to ensure robust growth under different and changing conditions. Genome compaction, removing sequences nonessential for given conditions, provides a novel way to understand the core principles of life. The synthetic chromosome rearrangement and modification by loxP-mediated evolution (SCRaMbLE) system is a unique feature implanted i ...
DOI:
10.1186/s13059-020-02232-8

8. Cell Wall and Hormone Interplay Controls Growth Asymmetry

Author:
Jewaria, Pawan Kumar; Yu, Meng; Li, Xiaojuan
Source:
Trends in plant science 2021 v.26 no.7 pp. 665-667
ISSN:
1360-1385
Subject:
cell growth,   etc   ; asymmetry; auxins; biosynthesis; cell wall components; cell walls;     Show all 6 Subjects
Abstract:
... Plant cell elongation and expansion require the biosynthesis and remodeling of cell wall composition. Recently, Aryal et al. reported how feedback between the cell wall and the auxin response controls differential growth in apical hook development. ...
DOI:
10.1016/j.tplants.2021.04.003

9. Self-assembly of trifunctional tripeptides to form neural scaffolds

Author:
Kulkarni, Ketav; Kelderman, Jenisi; Coleman, Harold; Aguilar, Marie-Isabel; Parkington, Helena; Del Borgo, Mark
Source:
Journal of materials chemistry B 2021 v.9 no.22 pp. 4475-4479
ISSN:
2050-7518
Subject:
cell growth,   etc   ; biocompatibility; biocompatible materials; growth and development; neurons; tripeptides;     Show all 6 Subjects
Abstract:
... Peptide self-assembly has been exploited to generate a multitude of biomaterials that exhibit biocompatibility due to their similarity to naturally occurring proteins. Previously, we have shown that β-tripeptides self-assemble despite containing sterically bulky, functional sidechains. Herein, we describe the synthesis of a novel β-amino acid to allow for the synthesis of a trifunctional β-tripept ...
DOI:
10.1039/d0tb02959a

10. Insights into the cyanosphere: capturing the respective metabolisms of cyanobacteria and chemotrophic bacteria in natural conditions?

Author:
Pascault, Noémie; Rué, Olivier; Loux, Valentin; Pédron, Jacques; Martin, Véronique; Tambosco, Jennifer; Bernard, Cécile; Humbert, Jean‐François; Leloup, Julie
Source:
Environmental microbiology reports 2021 v.13 no.3 pp. 364-374
ISSN:
1758-2229
Subject:
cell growth,   etc   ; Dolichospermum; Microcystis; lakes; metabolism; microbiome; phosphates; transcriptomics;     Show all 8 Subjects
Abstract:
... Specific interactions have been highlighted between cyanobacteria and chemotrophic bacteria within the cyanosphere, suggesting that nutrients recycling could be optimized by cyanobacteria/bacteria exchanges. In order to determine the respective metabolic roles of the cyanobacterial and bacterial consortia (microbiome), a day–night metatranscriptomic analysis was performed on Dolichospermum sp. (N₂ ...
DOI:
10.1111/1758-2229.12944

11. mTORC1 promotes cell growth via m6A-dependent mRNA degradation

Author:
Cho, Sungyun; Lee, Gina; Pickering, Brian F.; Jang, Cholsoon; Park, Jin H.; He, Long; Mathur, Lavina; Kim, Seung-Soo; Jung, Sunhee; Tang, Hong-Wen; Monette, Sebastien; Rabinowitz, Joshua D.; Perrimon, Norbert; Jaffrey, Samie R.; Blenis, John
Source:
Molecular cell 2021 v.81 no.10 pp. 2064-2075.e8
ISSN:
1097-2765
Subject:
cell growth,   etc   ; dimerization; methyltransferases; neoplasms; therapeutics; transcription (genetics);     Show all 6 Subjects
Abstract:
... Dysregulated mTORC1 signaling alters a wide range of cellular processes, contributing to metabolic disorders and cancer. Defining the molecular details of downstream effectors is thus critical for uncovering selective therapeutic targets. We report that mTORC1 and its downstream kinase S6K enhance eIF4A/4B-mediated translation of Wilms’ tumor 1-associated protein (WTAP), an adaptor for the N⁶-meth ...
DOI:
10.1016/j.molcel.2021.03.010

12. GW4064 enhances the chemosensitivity of colorectal cancer to oxaliplatin by inducing pyroptosis

Author:
Guo, Jing; Zheng, Jianbao; Mu, Mingchao; Chen, Zilu; Xu, Zhengshui; Zhao, Chenye; Yang, Kui; Qin, Xiao; Sun, Xuejun; Yu, Junhui
Source:
Biochemical and biophysical research communications 2021 v.548 pp. 60-66
ISSN:
0006-291X
Subject:
cell growth,   etc   ; colorectal neoplasms; drug resistance; drugs; pyroptosis; research;     Show all 6 Subjects
Abstract:
... Repeated and long-term oxaliplatin therapy leads to drug resistance and severe adverse events, which limit its clinical use. These difficulties highlight the importance of identifying potent and specific drug combinations to enhance the antitumor effects of oxaliplatin. The farnesoid X receptor (FXR) deficiency in colorectal cancer (CRC) suggests that restoring FXR function might be a promising st ...
DOI:
10.1016/j.bbrc.2021.02.043

13. Latrunculin B facilitates gravitropic curvature of Arabidopsis root by inhibiting cell elongation, especially the cells in the lower flanks of the transition and elongation zones

Author:
Xu, Shi; Wang, Qianqian; Liu, Yue; Liu, Zonghao; Zhao, Ruoxin; Sheng, Xianyong
Source:
Plant signaling & behavior 2021 v.16 no.4 pp. 1876348
ISSN:
1559-2324
Subject:
cell growth,   etc   ; Arabidopsis; behavior; gravitropism; growth and development; microfilaments;     Show all 6 Subjects
Abstract:
... Gravitropism plays a critical role in the growth and development of plants. Previous reports proposed that the disruption of the actin cytoskeleton resulted in enhanced gravitropism; however, the mechanism underlying these phenomena is still unclear. In the present study, real-time observation on the effect of Latrunculin B (Lat B), a depolymerizing agent of microfilament cytoskeleton, on gravitro ...
DOI:
10.1080/15592324.2021.1876348

14. Osteogenic potential of the growth factors and bioactive molecules in bone regeneration

Author:
Safari, Banafsheh; Davaran, Soodabeh; Aghanejad, Ayuob
Source:
International journal of biological macromolecules 2021 v.175 pp. 544-557
ISSN:
0141-8130
Subject:
cell growth,   etc   ; angiogenesis; bone formation; bones; cytokines; tissue repair;     Show all 6 Subjects
Abstract:
... The growing need for treatment of the impaired bone tissue has resulted in the quest for the improvement of bone tissue regeneration strategies. Bone tissue engineering is trying to create bio-inspired systems with a coordinated combination of the cells, scaffolds, and bioactive factors to repair the damaged bone tissue. The scaffold provides a supportive matrix for cell growth, migration, and dif ...
DOI:
10.1016/j.ijbiomac.2021.02.052

15. Regulation and function of class A Penicillin-binding proteins

Author:
Pazos, Manuel; Vollmer, Waldemar
Source:
Current opinion in microbiology 2021 v.60 pp. 80-87
ISSN:
1369-5274
Subject:
cell growth,   etc   ; cell division; cell membranes; peptides; peptidoglycans; turgor;     Show all 6 Subjects
Abstract:
... Most bacteria surround their cell membrane with a peptidoglycan sacculus that counteracts the turgor and maintains the shape of the cell. Class A PBPs are bi-functional glycosyltransferase-transpeptidases that polymerize glycan chains and cross-link peptides. They have a major contribution to the total peptidoglycan synthesized during cell growth and cell division. In recent years it became appare ...
DOI:
10.1016/j.mib.2021.01.008

16. SUMOylation modulates the stability and function of PI3K-p110β

Author:
El Motiam, Ahmed; de la Cruz-Herrera, Carlos F.; Vidal, Santiago; Seoane, Rocío; Baz-Martínez, Maite; Bouzaher, Yanis H.; Lecona, Emilio; Esteban, Mariano; Rodríguez, Manuel S.; Vidal, Anxo; Collado, Manuel; Rivas, Carmen
Source:
Cellular and molecular life sciences 2021 v.78 no.8 pp. 4053-4065
ISSN:
1420-682X
Subject:
cell growth,   etc   ; carcinogenesis; lysine; phosphatidylinositol 3-kinase; protein subunits; sumoylation;     Show all 6 Subjects
Abstract:
... Class I PI3K are heterodimers composed of a p85 regulatory subunit and a p110 catalytic subunit involved in multiple cellular functions. Recently, the catalytic subunit p110β has emerged as a class I PI3K isoform playing a major role in tumorigenesis. Understanding its regulation is crucial for the control of the PI3K pathway in p110β-driven cancers. Here we sought to evaluate the putative regulat ...
DOI:
10.1007/s00018-021-03826-6

17. Genome Size Covaries More Positively with Propagule Size than Adult Size: New Insights into an Old Problem

Author:
Glazier, Douglas S.
Source:
Biology 2021 v.10 no.4
ISSN:
2079-7737
Subject:
cell growth,   etc   ; DNA; adults; body size; eggs; genome; metabolism;     Show all 7 Subjects
Abstract:
... The body size and (or) complexity of organisms is not uniformly related to the amount of genetic material (DNA) contained in each of their cell nuclei (‘genome size’). This surprising mismatch between the physical structure of organisms and their underlying genetic information appears to relate to variable accumulation of repetitive DNA sequences, but why this variation has evolved is little under ...
DOI:
10.3390/biology10040270

18. Molecular interactions and their predictive roles in cell pole determination in bacteria

Author:
Chaudhary, Reema; Mishra, Shruti; Kota, Swathi; Misra, Hari
Source:
Critical reviews in microbiology 2021 v.47 no.2 pp. 141-161
ISSN:
1549-7828
Subject:
cell growth,   etc   ; bacteria; cell walls; chromosome duplication; cytokinesis; models; separation;     Show all 7 Subjects
Abstract:
... Bacterial cell cycle is divided into well-coordinated phases; chromosome duplication and segregation, cell elongation, septum formation, and cytokinesis. The temporal separation of these phases depends upon the growth rates and doubling time in different bacteria. The entire process of cell division starts with the assembly of divisome complex at mid-cell position followed by constriction of the c ...
DOI:
10.1080/1040841X.2020.1857686

19. Implications of ionizing radiation on pollen performance in comparison with diverse models of polar cell growth

Author:
Stephan, Octavian O. H.
Source:
Plant, cell and environment 2021 v.44 no.3 pp. 665-691
ISSN:
0140-7791
Subject:
cell growth,   etc   ; gametophytes; germination; humans; males; phylogeny; pollen; sporophytes; surveys;     Show all 9 Subjects
Abstract:
... Research concerning the effects of ionizing radiation (IR) on plant systems is essential for numerous aspects of human society, as for instance, in terms of agriculture and plant breeding, but additionally for elucidating consequences of radioactive contamination of the ecosphere. This comprehensive survey analyses effects of x‐ and γ‐irradiation on male gametophytes comprising primarily in vitro ...
DOI:
10.1111/pce.13929

20. LHPP suppresses tumorigenesis of intrahepatic cholangiocarcinoma by inhibiting the TGFβ/smad signaling pathway

Author:
Wang, Dan; Ning, Zhouyu; Zhu, Zhenfeng; Zhang, Chenyue; Wang, Peng; Meng, Zhiqiang
Source:
The international journal of biochemistry & cell biology 2021 v.132 pp. 105845
ISSN:
1357-2725
Subject:
cell growth,   etc   ; carcinogenesis; histidine; metastasis; neoplasm progression; neoplasms; phosphorylation; therapeutics;     Show all 8 Subjects
Abstract:
... Phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP), a histidine phosphatase, plays an important role in tumor progression and metastasis as a tumor suppressor. Here, we investigate the effect of LHPP in intrahepatic cholangiocarcinoma (ICC). We discovered that LHPP was downregulated in tumor tissues and low levels of LHPP predicted poor survival. LHPP inhibited ICC cell grow ...
DOI:
10.1016/j.biocel.2020.105845