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1. Cytoskeleton Architecture Regulates Glycolysis Coupling Cellular Metabolism to Mechanical Cues

Author:
Fernie, Alisdair R.; Zhang, Youjun; Sampathkumar, Arun
Source:
Trends in biochemical sciences 2020 v.45 no.8 pp. 637-638
ISSN:
0968-0004
Subject:
cell growth,   etc   ; actin; cytoskeleton; extracellular matrix; glycolysis;     Show all 5 Subjects
Abstract:
... Energy-demanding processes, such as cell growth, migration, and differentiation, are tension modulated, begging the question whether metabolism and mechanical tension are tightly linked. A recent report by Park et al. shows that stiffness in the extracellular matrix (ECM) promotes reorganization of actin, resulting in enhanced glycolysis. ...
DOI:
10.1016/j.tibs.2020.04.003

2. Materials and technical innovations in 3D printing in biomedical applications

Author:
Tetsuka, Hiroyuki; Shin, Su Ryon
Source:
Journal of materials chemistry B 2020 v.8 no.15 pp. 2930-2950
ISSN:
2050-7518
Subject:
cell growth,   etc   ; comparative study; geometry; medicine; three-dimensional printing;     Show all 5 Subjects
Abstract:
... 3D printing is a rapidly growing research area, which significantly contributes to major innovations in various fields of engineering, science, and medicine. Although the scientific advancement of 3D printing technologies has enabled the development of complex geometries, there is still an increasing demand for innovative 3D printing techniques and materials to address the challenges in building s ...
DOI:
10.1039/d0tb00034e

3. Re-engineering Artificial Neoplastic Milieus: Taking Lessons from Mechano- and Topobiology

Author:
Leal-Egaña, Aldo; Balland, Martial; Boccaccini, Aldo R.
Source:
Trends in biotechnology 2020 v.38 no.2 pp. 142-153
ISSN:
0167-7799
Subject:
cell growth,   etc   ; biophysics; niches; tissue engineering; tissue repair; tissues;     Show all 6 Subjects
Abstract:
... Traditionally, cancer-like scaffolds have been developed with tissue regeneration in mind and therefore designed to mimic the regenerative environment of otherwise healthy tissues. However, the tumoral niche exhibits specific biophysical cues far from being ‘cell friendly’, suggesting that a different approach should be taken to design these artificial neoplastic niches. From bare 2D surfaces to 3 ...
DOI:
10.1016/j.tibtech.2019.08.003

4. The shortcomings of accurate rate estimations in cultivation processes and a solution for precise and robust process modeling

Author:
Bayer, B.; Sissolak, B.; Duerkop, M.; von Stosch, M.; Striedner, G.
Source:
Bioprocess and biosystems engineering 2020 v.43 no.2 pp. 169-178
ISSN:
1615-7591
Subject:
cell growth,   etc   ; Escherichia coli; batch fermentation; bioprocessing; models;     Show all 5 Subjects
Abstract:
... The accurate estimation of cell growth or the substrate consumption rate is crucial for the understanding of the current state of a bioprocess. Rates unveil the actual cell status, making them valuable for quality-by-design concepts. However, in bioprocesses, the real rates are commonly not accessible due to analytical errors. We simulated Escherichia coli fed-batch fermentations, sampled at four ...
DOI:
10.1007/s00449-019-02214-6
PubMed:
31541314
PubMed Central:
PMC6960212

5. Growth and the cell cycle in green algae dividing by multiple fission

Author:
Ivanov, Ivan Nedyalkov; Vítová, Milada; Bišová, Kateřina
Source:
Folia microbiologica 2019 v.64 no.5 pp. 663-672
ISSN:
0015-5632
Subject:
cell growth,   etc   ; Chlorophyta; cell division;     Show all 3 Subjects
Abstract:
... Most cells divide into two daughter cells; however, some green algae can have different division patterns in which a single mother cell can sometimes give rise to up to thousands of daughter cells. Although such cell cycle patterns can be very complex, they are governed by the same general concepts as the most common binary fission. Moreover, cell cycle progression appears to be connected with siz ...
DOI:
10.1007/s12223-019-00741-z

6. A differential evolution approach to estimate parameters in a temperature-dependent kinetic model for second generation ethanol production under high cell density with Spathaspora passalidarum

Author:
Biazi, L.E.; Martínez-Jimenez, F.D.; Bonan, C.I.D.G.; Soares, L.B.; Morais, E.R.; Ienczak, J.L.; Costa, A.C.
Source:
Biochemical engineering journal 2020 v.161 pp. 107586
ISSN:
1369-703X
Subject:
cell growth,   etc   ; algorithms; equations; ethanol fermentation; ethanol production; glucose; kinetics; simulation models; temperature; xylose; yeasts;     Show all 11 Subjects
Abstract:
... An unstructured–unsegregated temperature-dependent kinetic model was developed and validated to describe ethanol fermentation in a mixture of xylose and glucose for the nonconventional yeast Spathaspora passalidarum NRRL Y-27907 under high cell density in the temperature range of 26–32 °C. The kinetic model consisted of 13 equations and 16 kinetic parameters, describing cell growth, individual xyl ...
DOI:
10.1016/j.bej.2020.107586

7. Coupling of Ribosome Synthesis and Translational Capacity with Cell Growth

Author:
Dai, Xiongfeng; Zhu, Manlu
Source:
Trends in biochemical sciences 2020 v.45 no.8 pp. 681-692
ISSN:
0968-0004
Subject:
cell growth,   etc   ; bacteria; eukaryotic cells; neoplasm cells; neoplasms; protein synthesis; ribosomes; yeasts;     Show all 8 Subjects
Abstract:
... Ribosome and protein synthesis lie at the core of cell growth and are major consumers of the cellular budget. Here we review recent progress in the coupling of ribosome synthesis and translational capacity with cell growth in bacteria. We elaborate on the different strategies of bacteria to modulate the protein synthesis rate at fast and slow growth rates. In particular, bacterial cells maintain t ...
DOI:
10.1016/j.tibs.2020.04.010

8. Regulation of trehalose, a typical stress protectant, on central metabolisms, cell growth and division of Saccharomyces cerevisiae CEN.PK113-7D

Author:
Zhang, Xiaoru; Zhang, Yaxian; Li, Hao
Source:
Food microbiology 2020 v.89 pp. 103459
ISSN:
0740-0020
Subject:
cell growth,   etc   ; Saccharomyces cerevisiae; adenosine triphosphate; cell cycle; energy; ethanol; fermentation; glucose; glycolysis; trehalose; yeasts;     Show all 11 Subjects
Abstract:
... Trehalose could protect the typical food microorganism Saccharomyces cerevisiae cell against environmental stresses; however, the other regulation effects of trehalose on yeast cells during the fermentation are still poorly understood. In this manuscript, different concentrations (i.e., 0, 2 and 5% g/v) of trehalose were respectively added into the medium to evaluate the effect of trehalose on gro ...
DOI:
10.1016/j.fm.2020.103459

9. CircCBFB-mediated miR-28-5p facilitates abdominal aortic aneurysm via LYPD3 and GRIA4

Author:
Yue, Jianing; Zhu, Ting; Yang, Jue; Si, Yi; Xu, Xin; Fang, Yuan; Fu, Weiguo
Source:
Life sciences 2020 v.253 pp. 117533
ISSN:
0024-3205
Subject:
cell growth,   etc   ; aneurysm; apoptosis; bioinformatics; circular RNA; glutamic acid; messenger RNA; microRNA; myocytes; smooth muscle;     Show all 10 Subjects
Abstract:
... Abdominal aortic aneurysm (AAA) is featured by the growth impediment and apoptosis surge of VSMCs (vascular smooth muscle cells). MicroRNAs (miRNAs) are suggested to affect cellular behaviors including cell growth and apoptosis. This study concentrated on unraveling the emerging role of miR-28-5p in abdominal aortic aneurysm.Previously, miR-28-5p was reported to be highly expressed in AAA. Functio ...
DOI:
10.1016/j.lfs.2020.117533

10. Therapeutic applications of AS1411 aptamer, an update review

Author:
Yazdian-Robati, Rezvan; Bayat, Payam; Oroojalian, Fatemeh; Zargari, Mehryar; Ramezani, Mohammad; Taghdisi, Seyed Mohammad; Abnous, Khalil
Source:
International journal of biological macromolecules 2020 v.155 pp. 1420-1431
ISSN:
0141-8130
Subject:
cell growth,   etc   ; cancer therapy; cell nucleolus; neoplasm cells; neoplasms; oligonucleotides; phosphoproteins;     Show all 7 Subjects
Abstract:
... Nucleolin or C23, is one of the most abundant non-ribosomal phosphoproteins of nucleolus. However, in several cancers, nucleolin is highly expressed both intracellularly and on the cell surface. So, it is considered as a potential target for the diagnosis and cancer therapy.Targeting nucleolin by compounds such as AS1411 aptamer can reduce tumor cell growth. In this regard, interest has increased ...
DOI:
10.1016/j.ijbiomac.2019.11.118

11. Dynamic monitoring and quantitative characterization of intracellular H2O2 content by using SERS based boric acid nanoprobe

Author:
Cheng, Wendai; Tang, Ping; He, Xuanmeng; Xing, Xinyue; Xing, Meishuang; Lu, Liupeng; Ju, Peng; Wang, Yi; Liu, Shengde; Lu, Xiaoxu; Zhong, Liyun
Source:
Talanta 2020 v.214 pp. 120863
ISSN:
0039-9140
Subject:
cell growth,   etc   ; Raman spectroscopy; apoptosis; boric acid; gold; hydrogen peroxide; monitoring; nanogold; nanorods; thiols;     Show all 10 Subjects
Abstract:
... Quantitative characterization of intracellular H₂O₂ content, which is still difficult by the conventional biochemical methods due to the lack of real-time and non-invasive technique of single cell measurement, is a useful solution for cell state assessment. Based on the surface enhanced Raman scattering (SERS), we construct a novel boric acid (BA) nanoprobe to perform quantitative characterization ...
DOI:
10.1016/j.talanta.2020.120863

12. A dynamic cell recruitment process drives growth of the Drosophila wing by overscaling the vestigial expression pattern

Author:
Muñoz-Nava, Luis Manuel; Alvarez, Hugo Ariel; Flores-Flores, Marycruz; Chara, Osvaldo; Nahmad, Marcos
Source:
Developmental biology 2020 v.462 no.2 pp. 141-151
ISSN:
0012-1606
Subject:
cell growth,   etc   ; Drosophila; adults; apoptosis; cell proliferation; fluorescence; genes; larval development; mathematical models; wings;     Show all 10 Subjects
Abstract:
... Organs mainly attain their size by cell growth and proliferation, but sometimes also grow through recruitment of undifferentiated cells. Here we investigate the participation of cell recruitment in establishing the pattern of Vestigial (Vg), the product of the wing selector gene in Drosophila. We find that the Vg pattern overscales along the dorsal-ventral (DV) axis of the wing imaginal disc, i.e. ...
DOI:
10.1016/j.ydbio.2020.03.009

13. ShapeMetrics: A userfriendly pipeline for 3D cell segmentation and spatial tissue analysis

Author:
Takko, Heli; Pajanoja, Ceren; Kurtzeborn, Kristen; Hsin, Jenny; Kuure, Satu; Kerosuo, Laura
Source:
Developmental biology 2020 v.462 no.1 pp. 7-19
ISSN:
0012-1606
Subject:
cell growth,   etc   ; artificial intelligence; bioinformatics; biomarkers; digital images; fluorescence; surface area; tissue analysis;     Show all 8 Subjects
Abstract:
... The demand for single-cell level data is constantly increasing within life sciences. In order to meet this demand, robust cell segmentation methods that can tackle challenging in vivo tissues with complex morphology are required. However, currently available cell segmentation and volumetric analysis methods perform poorly on 3D images. Here, we generated ShapeMetrics, a MATLAB-based script that se ...
DOI:
10.1016/j.ydbio.2020.02.003

14. Enhanced rhamnolipids production in Pseudomonas aeruginosa SG by selectively blocking metabolic bypasses of glycosyl and fatty acid precursors

Author:
Lei, Liying; Zhao, Feng; Han, Siqin; Zhang, Ying
Source:
Biotechnology letters 2020 v.42 no.6 pp. 997-1002
ISSN:
0141-5492
Subject:
cell growth,   etc   ; Pseudomonas aeruginosa; biosynthesis; exopolysaccharides; fatty acids; fermentation; genes; mutants; polyhydroxyalkanoates; rhamnolipids;     Show all 10 Subjects
Abstract:
... OBJECTIVE: To enhance rhamnolipids production in Pseudomonas aeruginosa, an optimization strategy based on selectively blocking the metabolic bypass that competed precursors with rhamnolipids biosynthesis pathway, containing exopolysaccharide (Psl and Pel) and polyhydroxyalkanoates (PHA) synthesis pathways. RESULTS: Blocking the synthesis of Psl and PHA by genes knockout, both mutants P. aeruginos ...
DOI:
10.1007/s10529-020-02838-9

15. Yeast systems biology in understanding principles of physiology underlying complex human diseases

Author:
Yu, Rosemary; Nielsen, Jens
Source:
Current opinion in biotechnology 2020 v.63 pp. 63-69
ISSN:
0958-1669
Subject:
cell growth,   etc   ; experimental design; gene expression; human diseases; metabolism; models; multiomics; nutrient content; yeasts;     Show all 9 Subjects
Abstract:
... Complex human diseases commonly arise from deregulation of cell growth, metabolism, and/or gene expression. Yeast is a eukaryal model organism that is widely used to study these processes. Yeast systems biology benefits from the ability to exert fine experimental control over the cell growth rate and nutrient composition, which allows orthogonal experimental design and generation of multi-omics da ...
DOI:
10.1016/j.copbio.2019.11.021

16. Engineered transient and stable overexpression of translation factors eIF3i and eIF3c in CHOK1 and HEK293 cells gives enhanced cell growth associated with increased c-Myc expression and increased recombinant protein synthesis

Author:
Roobol, Anne; Roobol, Joanne; Smith, Matthew E.; Carden, Martin J.; Hershey, John W.B.; Willis, Anne E.; Smales, C. Mark
Source:
Metabolic engineering 2020 v.59 pp. 98-105
ISSN:
1096-7176
Subject:
cell growth,   etc   ; biomass production; biopharmaceuticals; cell proliferation; engineering; human cell lines; mammals; protein synthesis; recombinant proteins;     Show all 9 Subjects
Abstract:
... There is a desire to engineer mammalian host cell lines to improve cell growth/biomass accumulation and recombinant biopharmaceutical protein production in industrially relevant cell lines such as the CHOK1 and HEK293 cell lines. The over-expression of individual subunits of the eukaryotic translation factor eIF3 in mammalian cells has previously been shown to result in oncogenic properties being ...
DOI:
10.1016/j.ymben.2020.02.001
PubMed:
32061967
PubMed Central:
PMC7118365

17. Influence of Medium Composition on the Production of Phycocyanin from Anabaena variabilis

Author:
Cottas, Arthur Godoy; Cunha, Warlley Rosa; Ribeiro, Eloízio Júlio; de Souza Ferreira, Juliana
Source:
Industrial biotechnology 2020 v.16 no.2 pp. 45-49
ISSN:
1931-8421
Subject:
cell growth,   etc   ; Anabaena variabilis; biotechnology; color; culture media; glucose; microorganisms; nitrates; phycocyanin; pigments;     Show all 10 Subjects
Abstract:
... Cyanobacteria are a group of microorganisms that have been studied for pigment production. Among these pigments, phycobiliproteins, especially the phycocyanin (PC), of blue color, are found in great quantity. To evaluate cell growth and the synthesis of PC from Anabaena variabilis, different conditions to supplement basal culture medium (BG11₀) were applied. A common composition that allowed to ob ...
DOI:
10.1089/ind.2019.29196.agc

18. Active telomerase during leaf growth and increase of age in plants from Agave tequilana var. Azul

Author:
De la Torre-Espinosa, Zamaria Yoselin; Barredo-Pool, Felipe; Castaño de la Serna, Enrique; Sánchez-Teyer, Lorenzo Felipe
Source:
Physiology and molecular biology of plants 2020 v.26 no.4 pp. 639-647
ISSN:
0971-5894
Subject:
cell growth,   etc   ; Agave tequilana; cell differentiation; enzyme activity; leaves; telomerase; telomeres; tissues; vascular bundles; vegetative growth;     Show all 10 Subjects
Abstract:
... In plants, previous studies show that telomerase activity contributes to the maintenance of telomeric length for the proper development of organs and tissues. In this work, we investigated telomerase activity in A. tequilana during several years of cultivation. We found that during growth of the leaf there are two crucial phases: (1) the onset of cell elongation in 3 years and (2) differentiation ...
DOI:
10.1007/s12298-020-00781-7
PubMed:
32255928
PubMed Central:
PMC7113356

19. Addressing the critical challenge for rhamnolipid production: Discontinued synthesis in extended stationary phase

Author:
Sodagari, Maysam; Ju, Lu-Kwang
Source:
Process biochemistry 2020 v.91 pp. 83-89
ISSN:
1359-5113
Subject:
cell growth,   etc   ; Pseudomonas aeruginosa; fermentation; metabolites; nutrients; oils; production economics; quorum sensing; rhamnolipids; sigma factors;     Show all 10 Subjects
Abstract:
... Rhamnolipids are commonly produced using N-limited Pseudomonas aeruginosa fermentations, with active production in the stationary phase. The production, however, stops after certain period. This causes lower productivity and yield because of downtime between batches and the substrate consumed for cell growth. This discontinued production is the significant problem addressed in this study. Rhamnoli ...
DOI:
10.1016/j.procbio.2019.11.036

20. Endoreplication — a means to an end in cell growth and stress response

Author:
Lang, Lucas; Schnittger, Arp
Source:
Current opinion in plant biology 2020 v.54 pp. 85-92
ISSN:
1369-5266
Subject:
cell growth,   etc   ; biotechnology; cell differentiation; endopolyploidy; endosperm; genome; genomics; mitosis; stress response;     Show all 9 Subjects
Abstract:
... Endoreplication, also called endoreduplication or endopolyploidization, is a cell cycle variant in which the genome is re-replicated in the absence of mitosis causing cellular polyploidization. Despite the common occurrence of endoreplication in plants and the tremendous extent in specific tissues and cell types such as the endosperm, the underlying molecular regulation and the physiological conse ...
DOI:
10.1016/j.pbi.2020.02.006