PubAg

Main content area

You searched for: Subject "cell growth" Remove constraint Subject: "cell growth"
Start Over

Search

10,640  Search Results

« Previous | 1 - 20 of 10,640 |
Number of results to display per page

Search Results

1. Wiring cell growth to product formation

Author:
Buerger, Josi; Gronenberg, Luisa S.; Genee, Hans Jasper; Sommer, Morten O.A.
Source:
Current opinion in biotechnology 2019 v.59 pp. 85-92
ISSN:
0958-1669
Subject:
cell growth,   etc   ; clones; metabolism; metabolites; synthetic biology; toxicity;     Show all 6 Subjects
Abstract:
... Microbial cell factories offer new and sustainable production routes for high-value chemicals. However, identification of high producers within a library of clones remains a challenge. When product formation is coupled to growth, millions of metabolic variants can be effectively interrogated by growth selection, dramatically increasing the throughput of strain evaluation. While growth-coupled sele ...
DOI:
10.1016/j.copbio.2019.02.014

2. Beyond the vicious cycle: The role of innate osteoimmunity, automimicry and tumor-inherent changes in dictating bone metastasis

Author:
Owen, Katie L.; Parker, Belinda S.
Source:
Molecular immunology 2019 v.110 pp. 57-68
ISSN:
0161-5890
Subject:
cell growth,   etc   ; cell viability; metastasis; mortality; neoplasm cells; patients; therapeutics;     Show all 7 Subjects
Abstract:
... Bone metastasis is a fatal consequence of a subset of solid malignancies that fail to respond to conventional therapies. While a myriad of factors contribute to osteotropism and disseminated cell survival and outgrowth in bone, efforts to inhibit tumor cell growth in the bone-metastatic niche have largely relied on measures that disrupt the bi-directional interactions between bone resident and tum ...
DOI:
10.1016/j.molimm.2017.11.023

3. OptCouple: Joint simulation of gene knockouts, insertions and medium modifications for prediction of growth-coupled strain designs

Author:
Jensen, Kristian; Broeken, Valentijn; Hansen, Anne Sofie Lærke; Sonnenschein, Nikolaus; Herrgård, Markus J.
Source:
Metabolic Engineering Communications 2019 v.8 pp. e00087
ISSN:
2214-0301
Subject:
cell growth,   etc   ; algorithms; biological production; computer software; environmental impact; prediction;     Show all 6 Subjects
Abstract:
... Biological production of chemicals is an attractive alternative to petrochemical-based production, due to advantages in environmental impact and the spectrum of feasible targets. However, engineering microbial strains to overproduce a compound of interest can be a long, costly and painstaking process. If production can be coupled to cell growth it is possible to use adaptive laboratory evolution t ...
DOI:
10.1016/j.mec.2019.e00087

4. One is Nothing without the Other: Theoretical and Empirical Analysis of Cell Growth and Cell Cycle Progression

Author:
Levin, Petra Anne; Taheri-Araghi, Sattar
Source:
Journal of molecular biology 2019 v.431 no.11 pp. 2061-2067
ISSN:
0022-2836
Subject:
cell growth,   etc   ; bacteria; cell cycle; empirical research; quantitative analysis;     Show all 5 Subjects
Abstract:
... Small, fast-growing bacteria make ideal subjects for genetic and quantitative analysis alike. Long the darling of theoreticians, efforts to understand the relationship between cell growth and cell cycle progression in bacterial systems have been propelled by modelers and empiricist in equal measure. Taking a historical approach, here we break down early work in this area, the impact it had on how ...
DOI:
10.1016/j.jmb.2019.04.004

5. Integrated strategy of temperature shift and mannitol feeding for enhanced production of echinocandin B by Aspergillus nidulans CCTCC M2012300

Author:
Zou, Shu-Ping; Xiong, Yan; Niu, Kun; Hu, Zhong-Ce; Zheng, Yu-Guo
Source:
3 Biotech 2019 v.9 no.4 pp. 140
ISSN:
2190-572X
Subject:
cell growth,   etc   ; Aspergillus nidulans; batch fermentation; echinocandins; mannitol; temperature;     Show all 6 Subjects
Abstract:
... The production of echinocandin B (ECB) by Aspergillus nidulans CCTCC M2012300 was improved by integrating the temperature-shift and fed-batch control strategies. The kinetic characteristics of batch cultures were analyzed at different culture temperatures, and then a two-stage temperature control strategy was established. In the first 6 days, the temperature was maintained at 30 °C to obtain the m ...
DOI:
10.1007/s13205-019-1668-x

6. NF45 promotes esophageal squamous carcinoma cell invasion by increasing Rac1 activity through 14-3-3ε protein

Author:
Wen-Jian, Yao; song, Tong; Jun, Tan; Kai-Ying, Xu; Jian-Jun, Wang; Si-Hua, Wang
Source:
Archives of biochemistry and biophysics 2019 v.663 pp. 101-108
ISSN:
0003-9861
Subject:
cell growth,   etc   ; animal tissues; cell lines; squamous cell carcinoma; therapeutics;     Show all 5 Subjects
Abstract:
... Nuclear factor 45 (NF-45) has been found to be markedly upregulated in several cancers, including esophageal squamous cell carcinoma (ESCC). However, the molecular mechanisms underlying its functions remain unclear. In this study, we confirm that overexpression of NF45 was frequently detected in ESCC tissues and was associated with poor outcome. Overexpression studies revealed that NF-45 promoted ...
DOI:
10.1016/j.abb.2018.12.012

7. Crystal structures of arginine sensor CASTOR1 in arginine-bound and ligand free states

Author:
Zhou, Yanxia; Wang, Chen; Xiao, Qingjie; Guo, Li
Source:
Biochemical and biophysical research communications 2019 v.508 no.2 pp. 387-391
ISSN:
0006-291X
Subject:
cell growth,   etc   ; arginine; crystal structure; ligands; metabolism; rapamycin;     Show all 6 Subjects
Abstract:
... The mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) is a master regulator of metabolism and cell growth. Among the numerous extracellular and intracellular signals, certain amino acids activate mTORC1 in a Rag-dependent manner. Arginine can stimulate mTORC1 activity by releasing the inhibitor CASTOR1 (Cellular Arginine Sensor of mTORC1) from GATOR2, a positive regulator of mTORC1 which i ...
DOI:
10.1016/j.bbrc.2018.11.147

8. Fates of CD8+ T cells in Tumor Microenvironment

Author:
Maimela, Nomathamsanqa Resegofetse; Liu, Shasha; Zhang, Yi
Source:
Computational and Structural Biotechnology Journal 2019 v.17 pp. 1-13
ISSN:
2001-0370
Subject:
cell growth,   etc   ; CD8-positive T-lymphocytes; biotechnology; immunosuppression; neoplasms; prognosis;     Show all 6 Subjects
Abstract:
... Studies have reported a positive correlation between elevated CD8+ T cells in the tumor microenvironment (TME) and good prognosis in cancer. However, the mechanisms linking T cell tumor-infiltration and tumor rejection are yet to be fully understood. The cells and factors of the TME facilitate tumor development in various ways. CD8+ T cell function is influenced by a number of factors, including C ...
DOI:
10.1016/j.csbj.2018.11.004

9. Engineering Biology by Controlling Tissue Folding

Author:
Hookway, Tracy A.
Source:
Trends in biotechnology 2018 v.36 no.4 pp. 341-343
ISSN:
0167-7799
Subject:
cell growth,   etc   ; biotechnology; tissue engineering;     Show all 3 Subjects
Abstract:
... Achieving complex self-organization in vitro has remained a fundamental challenge in tissue engineering. A recent study in Developmental Cell by Hughes and colleagues uses computational and experimental approaches to understand and control the morphogenic process of tissue folding. These approaches provide an engineering framework to reproducibly control tissue shape. ...
DOI:
10.1016/j.tibtech.2018.02.003

10. Increasing DNA content for cost-effective oil production in Parachlorella kessleri

Author:
You, Zaizhi; Zhang, Qi; Miao, Xiaoling
Source:
Bioresource technology 2019 v.285 pp. 121332
ISSN:
0960-8524
Subject:
cell growth,   etc   ; DNA; Parachlorella kessleri; biomass; cost effectiveness; harvesting; lipid content; lipids; microalgae; oils; salt stress;     Show all 11 Subjects
Abstract:
... The aim of this work was to study salt stress effects on DNA content and oil production processes integrating harvesting, lipid accumulation and oil extraction. Salt-induced enlargement of Parachlorella kessleri cells, with increasing content of DNA and neutral lipid were found. The 34.77% neutral lipid content and biomass concentration of 0.83 g L−1 were obtained after 7 days of salt treatment, c ...
DOI:
10.1016/j.biortech.2019.121332

11. Long non-coding RNA 520 is a negative prognostic biomarker and exhibits pro-oncogenic function in nasopharyngeal carcinoma carcinogenesis through regulation of miR-26b-3p/USP39 axis

Author:
Xie, Tao; Pi, Guoliang; Yang, Bin; Ren, Hui; Yu, Jing; Ren, Qingrong; Zhou, Xiaoyi; Hu, Desheng; Zhang, Haiyuan; Zhang, Hao; Zhang, Qu; Hu, Liu; Li, Ying; Zhou, Fuxing
Source:
Gene 2019 v.707 pp. 44-52
ISSN:
0378-1119
Subject:
cell growth,   etc   ; biomarkers; carcinogenesis; carcinoma; non-coding RNA; patients; prognosis; proteinases; signal transduction;     Show all 9 Subjects
Abstract:
... Long non-coding RNAs (lncRNAs) have been wildly verified to modulate multiple tumorigenesis, especially nasopharyngeal carcinoma (NPC). In present study, we aims to investigate the role and mechanism of LINC00520 in the NPC carcinogenesis. Results indicated that LINC00520 was significantly increasing in NPC tissues and cells in comparison to their corresponding controls. Moreover, the aberrant ove ...
DOI:
10.1016/j.gene.2019.02.093

12. Over-expression of Vitreoscilla hemoglobin (VHb) and flavohemoglobin (FHb) genes greatly enhances pullulan production

Author:
Xue, Si-Jia; Jiang, Hong; Chen, Lu; Ge, Na; Liu, Guang-Lei; Hu, Zhong; Chi, Zhen-Ming; Chi, Zhe
Source:
International journal of biological macromolecules 2019 v.132 pp. 701-709
ISSN:
0141-8130
Subject:
cell growth,   etc   ; Aureobasidium; Vitreoscilla; fermentation; gene overexpression; genes; hemoglobin; oxygen; pullulan; sucrose; transcription (genetics);     Show all 11 Subjects
Abstract:
... Overexpression of the optimized Vitreoscilla hemoglobin (VHb) gene and the native flavohemoglobin (FHb) gene in Aureobasidium melanogenum P16 rendered a V6 strain and a F44 strain to overproduce pullulan compared to that produced by their wild type strain P16. The capacity to bind CO and oxygen in the V6 strain and the F44 strain was also obviously enhanced. At the same time, the transcriptional l ...
DOI:
10.1016/j.ijbiomac.2019.04.007

13. Two-dimensional thermoresponsive sub-microporous substrate for accelerated cell tissue growth and facile detachment

Author:
Fragal, Vanessa H.; Catori, Daniele M.; Fragal, Elizângela H.; Garcia, Francielle P.; Nakamura, Celso V.; Rubira, Adley F.; Silva, Rafael
Source:
Journal of colloid and interface science 2019 v.547 pp. 78-86
ISSN:
0021-9797
Subject:
cell growth,   etc   ; cell culture; mixing; polyethylene terephthalates; polystyrenes; porosity; temperature; tissue engineering; viability;     Show all 9 Subjects
Abstract:
... Thermoresponsive sub-microporous films having a lower critical solution temperature (LCST), promptly obtained by using the breath figure method, were applied to tissue engineering. These sub-microporous films, sized 100–400 nm, were prepared by blending poly(N-isopropylacrylamide) (PNIPAAm) with polystyrene (PS), in addition to applying the dynamic breath figure (BF) method. The thermoresponsive b ...
DOI:
10.1016/j.jcis.2019.03.071

14. Coupling feedback genetic circuits with growth phenotype for dynamic population control and intelligent bioproduction

Author:
Lv, Yongkun; Qian, Shuai; Du, Guocheng; Chen, Jian; Zhou, Jingwen; Xu, Peng
Source:
Metabolic engineering 2019 v.54 pp. 109-116
ISSN:
1096-7176
Subject:
cell growth,   etc   ; biochemical pathways; bioprocess engineering; fermentation; gene expression; metabolic engineering; phenotype; quality control; transcription factors;     Show all 9 Subjects
Abstract:
... Metabolic engineering entails target modification of cell metabolism to maximize cell's production potential. Due to the complexity of cell metabolism, feedback genetic circuits have emerged as basic tools to combat metabolic heterogeneity, enhance microbial cooperation as well as boost cell's productivity. This is generally achieved by applying social reward-punishment rules to eliminate cheaters ...
DOI:
10.1016/j.ymben.2019.03.009

15. Production and characterization of Spirulina sp. LEB 18 cultured in reused Zarrouk’s medium in a raceway-type bioreactor

Author:
Andrade, Bianca Bomfim; Cardoso, Lucas Guimarães; Assis, Denilson de Jesus; Costa, Jorge Alberto Vieira; Druzian, Janice Izabel; da Cunha Lima, Suzana Telles
Source:
Bioresource technology 2019 v.284 pp. 340-348
ISSN:
0960-8524
Subject:
cell growth,   etc   ; Spirulina; biofuels; biomass; bioreactors; carbohydrates; chemical composition; fatty acids; microalgae; phycocyanin; thermal properties;     Show all 11 Subjects
Abstract:
... The objective was to evaluate the effect of reusing Zarrouk's medium on a Spirulina sp. LEB 18 culture by determining kinetic parameters, chemical composition, biofuels, and thermal characterization. Cultivation was performed in a raceway bioreactor for 7 days, the supernatant was reused for four cycles. Culturing the microalga in the reused medium resulted in a cellular yield of 2.30 g L−1 (contr ...
DOI:
10.1016/j.biortech.2019.03.144

16. Assessment of fed-batch cultivation strategies for an inducible CHO cell line

Author:
Mellahi, Kahina; Brochu, Denis; Gilbert, Michel; Perrier, Michel; Ansorge, Sven; Durocher, Yves; Henry, Olivier
Source:
Journal of biotechnology 2019 v.298 pp. 45-56
ISSN:
0168-1656
Subject:
cell growth,   etc   ; antibodies; bioreactors; cell lines; cell viability; developmental stages; glucose; hypothermia; overfeeding; risk;     Show all 10 Subjects
Abstract:
... In order to maximize cell growth and productivity for an inducible CHO cell line expressing rituximab, various fed-batch culture strategies were investigated. In each case, the performance was evaluated for cultures induced at moderate and high cell density conditions (4 × 106 and 10 × 106 cells/mL) to assess the impact of the timing of induction. We first demonstrate the importance of starting th ...
DOI:
10.1016/j.jbiotec.2019.04.005

17. MiR-145 mediates cell morphology-regulated mesenchymal stem cell differentiation to smooth muscle cells

Author:
Yeh, Yi-Ting; Wei, Josh; Thorossian, Satenick; Nguyen, Katherine; Hoffman, Clarissa; del Álamo, Juan C.; Serrano, Ricardo; Li, Yi-Shuan Julie; Wang, Kuei-Chun; Chien, Shu
Source:
Biomaterials 2019 v.204 pp. 59-69
ISSN:
0142-9612
Subject:
cell growth,   etc   ; cell differentiation; cytoskeleton; geometry; mesenchymal stromal cells; microRNA; myocytes; phenotype; smooth muscle;     Show all 9 Subjects
Abstract:
... The use of biochemical signaling to derive smooth muscle cells (SMCs) from mesenchymal stem cells (MSCs) has been explored, but the induction of a fully functional SMC phenotype remains to be a major challenge. Cell morphology has been shown to regulate MSC differentiation into various lineages, including SMCs. We engineered substrates with microgrooves to induce cell elongation to study the mecha ...
DOI:
10.1016/j.biomaterials.2019.03.003

18. Multifaceted role of keratins in epithelial cell differentiation and transformation

Author:
Dmello, Crismita; Srivastava, Saumya S; Tiwari, Richa; Chaudhari, Pratik R; Sawant, Sharada; Vaidya, Milind M
Source:
Journal of biosciences 2019 v.44 no.2 pp. 33
ISSN:
0250-5991
Subject:
cell growth,   etc   ; apoptosis; cell differentiation; cell proliferation; epithelial cells; epithelium; glycosylation; keratin; neoplasms; phosphorylation; signal transduction;     Show all 11 Subjects
Abstract:
... Keratins, the epithelial-predominant members of the intermediate filament superfamily, are expressed in a pairwise, tissue-specific and differentiation-dependent manner. There are 28 type I and 26 type II keratins, which share a common structure comprising a central coiled coil α-helical rod domain flanked by two nonhelical head and tail domains. These domains harbor sites for major posttranslatio ...
DOI:
10.1007/s12038-019-9864-8

19. NaCl enhances Escherichia coli growth and isoprenol production in the presence of imidazolium-based ionic liquids

Author:
Wang, Shizeng; Cheng, Gang; Dong, Jie; Tian, Tian; Lee, Taek Soon; Mukhopadhyay, Aindrila; Simmons, Blake A.; Yuan, Qipeng; Singer, Steven W.
Source:
Bioresource technology reports 2019 v.6 pp. 1-5
ISSN:
2589-014X
Subject:
cell growth,   etc   ; Escherichia coli; acetates; biomass; enzymatic hydrolysis; fuel production; ionic liquids; polysaccharides; sodium chloride;     Show all 9 Subjects
Abstract:
... Certain ionic liquids (ILs) can be used to pretreat biomass to improve enzymatic hydrolysis of polysaccharides; however, residual ILs may inhibit biofuel production. In this study, the impact of NaCl on cell growth and isoprenol production of E. coli in the presence of ILs was studied. The final biomass of E. coli MG1655 and DH1 were in the presence of 50 mM 1-butyl-3-methylimidazolium chloride ([ ...
DOI:
10.1016/j.biteb.2019.01.021

20. R-phycoerythrin, R-phycocyanin and ABE production from Gelidium amansii by Clostridium acetobutylicum

Author:
Sukwong, Pailin; Sunwoo, In Yung; Nguyen, Trung Hau; Jeong, Gwi-Taek; Kim, Sung-Koo
Source:
Process biochemistry 2019 v.81 pp. 139-147
ISSN:
1359-5113
Subject:
cell growth,   etc   ; Clostridium acetobutylicum; Gelidium; acid hydrolysis; fermentation; galactose; glucose; macroalgae; pH; polysaccharides; proteins; saccharification; solvents;     Show all 13 Subjects
Abstract:
... The red seaweed, Gelidium amansii, contains proteins such as R-phycoerythrin and R-phycocyanin, as well as polysaccharides. Initial protein extraction from G. amansii yielded 53 μg/g R-phycoerythrin and 56 μg/g R-phycocyanin. After protein extraction, monosaccharides were produced using hyper thermal acid hydrolysis and enzymatic saccharification. Acetone–butanol–ethanol (ABE) was produced by Clos ...
DOI:
10.1016/j.procbio.2019.03.023