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1. Methylcellulose – a versatile printing material that enables biofabrication of tissue equivalents with high shape fidelity

Author:
Ahlfeld, T.; Guduric, V.; Duin, S.; Akkineni, A. R.; Schütz, K.; Kilian, D.; Emmermacher, J.; Cubo-Mateo, N.; Dani, S.; Witzleben, M. v.; Spangenberg, J.; Abdelgaber, R.; Richter, R. F.; Lode, A.; Gelinsky, M.
Source:
Biomaterials science 2020 v.8 no.8 pp. 2102-2110
ISSN:
2047-4849
Subject:
cell viability,   etc   ; biocompatible materials; biofabrication; bioprinting; methylcellulose; tissue engineering;     Show all 6 Subjects
Abstract:
... With the aid of biofabrication, cells can be spatially arranged in three dimensions, which offers the opportunity to guide tissue maturation in a better way compared to traditional tissue engineering approaches. A prominent technique allowing biofabrication of tissue equivalents is extrusion-based 3D (bio)printing, also called 3D (bio)plotting or robocasting, which comprises cells embedded in the ...
DOI:
10.1039/d0bm00027b

2. Contemporary Tools for Regulating Gene Expression in Bacteria

Author:
Kent, Ross; Dixon, Neil
Source:
Trends in biotechnology 2020 v.38 no.3 pp. 316-333
ISSN:
0167-7799
Subject:
cell viability,   etc   ; bacteria; gene expression; genes; molecular biology;     Show all 5 Subjects
Abstract:
... Insights from novel mechanistic paradigms in gene expression control have led to the development of new gene expression systems for bioproduction, control, and sensing applications. Coupled with a greater understanding of synthetic burden and modern creative biodesign approaches, contemporary bacterial gene expression tools and systems are emerging that permit fine-tuning of expression, enabling g ...
DOI:
10.1016/j.tibtech.2019.09.007

3. Bio-orthogonal click reaction-enabled highly specific in situ cellularization of tissue engineering scaffolds

Author:
Mao, Duo; Zhang, Chuangnian; Kenry,; Liu, Jing; Wang, Xiaoxiao; Li, Binhan; Yan, Hongyu; Hu, Fang; Kong, Deling; Wang, Zhihong; Liu, Bin
Source:
Biomaterials 2020 v.230 pp. 119615
ISSN:
0142-9612
Subject:
cell viability,   etc   ; macrophages; medicine; polymers; survival rate; tissue engineering; tissues;     Show all 7 Subjects
Abstract:
... Tissue engineering generally utilizes natural or synthetic scaffolds to repair or replace damaged tissues. However, due to the lack of guidance of biological signals, most of the implanted scaffolds have always suffered from poor in vivo cellularization. Herein, we demonstrate a bio-orthogonal reaction-based strategy to realize in situ specific and fast cellularization of tissue engineering scaffo ...
DOI:
10.1016/j.biomaterials.2019.119615

4. Tetramethylpyrazine reverses high-glucose induced hypoxic effects by negatively regulating HIF-1α induced BNIP3 expression to ameliorate H9c2 cardiomyoblast apoptosis

Author:
Liu, Shih-Ping; Shibu, Marthandam Asokan; Tsai, Fuu-Jen; Hsu, Yuan-Man; Tsai, Chang-Hai; Chung, Jing-Gung; Yang, Jai-Sing; Tang, Chih-Hsin; Wang, Shulin; Li, Qiaowen; Huang, Chih-Yang
Source:
Nutrition & metabolism 2020 v.17 no.1 pp. 12
ISSN:
1743-7075
Subject:
cell viability,   etc   ; apoptosis; cytotoxicity; glucose; hypoxia; hypoxia-inducible factor 1; patients; protein synthesis; pyrazines;     Show all 9 Subjects
Abstract:
... BACKGROUND: Diabetic patients are highly vulnerable to hypoxic injury, which is associated with hypoxia induced BNIP3 expression that subsequently activate apoptosis. Our previous research show that Tetramethylpyrazine (TMP), a food flavoring agent, represses the hypoxia induced BNIP3 expression attenuate myocardial apoptosis. In this study, we evaluate the effect of TMP to provide protection agai ...
DOI:
10.1186/s12986-020-0432-x
PubMed:
32021640
PubMed Central:
PMC6995207

5. Facile synthesis of 3D hierarchical micro-/nanostructures in capillaries for efficient capture of circulating tumor cells

Author:
Wu, Zhihua; Zhao, De; Zhang, Yanhua; Huang, Lili; Huang, Hui; Guo, Qianqian; Zhang, Wei; Hou, Chengyi; Wang, Hongzhi; Zhang, Qinghong; Duan, Yourong; Li, Yaogang
Source:
Journal of colloid and interface science 2020 v.575 pp. 108-118
ISSN:
0021-9797
Subject:
cell viability,   etc   ; binding sites; encapsulation; glass; nanowires; neoplasm cells; neoplasms; zinc; zinc oxide;     Show all 9 Subjects
Abstract:
... The efficient capture of rare circulating tumor cells (CTCs) with high viability is of great importance in cancer diagnosis. The integration of three-dimensional (3D) nanobiointerfaces with capillary flow channel platforms can efficiently improve CTC capture performance by providing abundant binding sites and increasing the likelihood of contact as samples flow through the microchannels. However, ...
DOI:
10.1016/j.jcis.2020.04.087

6. New biocompatible antibacterial wound dressing candidates; agar-locust bean gum and agar-salep films

Author:
Akkaya, Nil Erge; Ergun, Cagla; Saygun, Ayse; Yesilcubuk, Nese; Akel-Sadoglu, Nurten; Kavakli, I. Halil; Turkmen, Halit S.; Catalgil-Giz, Huceste
Source:
International journal of biological macromolecules 2020 v.155 pp. 430-438
ISSN:
0141-8130
Subject:
cell viability,   etc   ; agar; beans; biopharmaceuticals; gels; locust bean gum; permeability; phosphates; solubility; tensile strength; water vapor;     Show all 11 Subjects
Abstract:
... Agar has numerous applications in biomedical and biopharmaceutical fields in gel form. However the hard and tough nature of agar films and their vulnerability to microbial attacks prevent their usage in wound dressing applications. In this work, agar - locust bean gum (LBG) and agar - salep films were prepared for the first time to improve its physical, antimicrobial and cell viability properties. ...
DOI:
10.1016/j.ijbiomac.2020.03.214

7. PHF23 negatively regulates the autophagy of chondrocytes in osteoarthritis

Author:
Maimaitijuma, Talatibaike; Yu, Jia-Hong; Ren, Ya-Li; Yang, Xin; Liu, Heng; Meng, Zhi-Chao; Wang, Rui; Cui, Yun-Peng; Wu, Hao; Pan, Li-Ping; Jiao, Yang; Chen, Ying-Yu; Cao, Yong-Ping
Source:
Life sciences 2020 v.253 pp. 117750
ISSN:
0024-3205
Subject:
cell viability,   etc   ; Western blotting; autophagosomes; chloroquine; chondrocytes; collagen; elderly; interleukins; lysosomes; mitophagy; osteoarthritis; phosphorylation; staining; surgery;     Show all 14 Subjects
Abstract:
... Osteoarthritis (OA) is the main cause of disability and joint replacement surgery in the elderly. As a crucial cell survival mechanism, autophagy has been reported to decrease in OA. PHF23 is a new autophagy inhibitor which was first reported by us previously. This study aimed to explore the anti-autophagic mechanism of PHF23 to make it a possible therapeutic target of OA.Lentiviral vectors specif ...
DOI:
10.1016/j.lfs.2020.117750

8. Alpinetin Inhibits Oral Squamous Cell Carcinoma Proliferation via miR-211-5p Upregulation and Notch Pathway Deactivation

Author:
Guo, Yanjun; Chen, Yong; Liu, Hongli; Yan, Wei
Source:
Nutrition and cancer 2020 v.72 no.5 pp. 757-767
ISSN:
1532-7914
Subject:
cell viability,   etc   ; cyclins; gene overexpression; human cell lines; interphase; mice; models; plasmids; squamous cell carcinoma;     Show all 9 Subjects
Abstract:
... Background: The effect of alpinetin (ALP) on miR-211-5p level and function in oral squamous cell carcinoma (OSCC) remains unclear. Materials and methods: Human OSCC cell lines (CAL-27 and TCA-8113) and a mouse xenograft model with subcutaneously injected TCA-8113 cells were used. Effect of ALP treatment on cell viability, cell cycle distributions, and p-p53, p21, c-PARP, cyclin D1, NICD, HES1, and ...
DOI:
10.1080/01635581.2019.1651878

9. Advancements in understanding the role of lysophospholipids and their receptors in lung disorders including bronchopulmonary dysplasia

Author:
Sudhadevi, Tara; Ha, Alison W.; Ebenezer, David L.; Fu, Panfeng; Putherickal, Vijay; Natarajan, Viswanathan; Harijith, Anantha
Source:
Biochimica et biophysica acta 2020 v.1865 no.7 pp. 158685
ISSN:
1388-1981
Subject:
cell viability,   etc   ; bronchopulmonary dysplasia; cell death; etiology; immune response; infants; lipids; lungs; morbidity; receptors;     Show all 10 Subjects
Abstract:
... Bronchopulmonary dysplasia (BPD) is a devastating chronic neonatal lung disease leading to serious adverse consequences. Nearly 15 million babies are born preterm accounting for >1 in 10 births globally. The aetiology of BPD is multifactorial and the survivors suffer lifelong respiratory morbidity. Lysophospholipids (LPL), which include sphingosine-1-phosphate (S1P), and lysophosphatidic acid (LPA ...
DOI:
10.1016/j.bbalip.2020.158685
PubMed:
32169655
PubMed Central:
PMC7206974

10. Evaluation of bioaerosols by flow cytometry and removal performance in a biofilter treating toluene/ethyl acetate vapors

Author:
Flores-Barbosa, Ana Betsabé; Aizpuru, Aitor; Quijano, Guillermo; Arriaga, Sonia
Source:
Chemosphere 2020 v.251 pp. 126404
ISSN:
0045-6535
Subject:
cell viability,   etc   ; bioaerosols; biofilters; ethyl acetate; flow cytometry; perlite; starvation; toluene; vapors;     Show all 9 Subjects
Abstract:
... The removal efficiency (RE) and bioaerosol emission of a perlite biofilter treating vapors of toluene (T) and/or ethyl acetate (EA) were assessed, under different operating conditions, during 171 days. Under the first stages of operation, a mixture of EA and T was treated, with equivalent inlet loads (ILs) of each compound (ranging from 26 to 84 g m⁻³ h⁻¹), achieving a 100% RE of EA, and a maximum ...
DOI:
10.1016/j.chemosphere.2020.126404

11. Poly(lactic acid)/gelatin foams by non-solvent induced phase separation for biomedical applications

Author:
Rarima, R.; Unnikrishnan, G.
Source:
Polymer degradation and stability 2020 v.177 pp. 109187
ISSN:
0141-3910
Subject:
cell viability,   etc   ; biodegradability; crystal structure; foams; gelatin; hydrophilicity; metformin; polylactic acid; porosity; separation;     Show all 10 Subjects
Abstract:
... Poly (lactic acid)/gelatin foams with porous structures have been prepared by thermally impacted non-solvent induced phase separation. Gelatin, being hydrophilic and biocompatible but non-foamable independently, has been employed as an additive to generate porous patterning in a mechanically stable poly (lactic acid) matrix. The amount of gelatin has been found to influence the crystallinity, whic ...
DOI:
10.1016/j.polymdegradstab.2020.109187

12. A PI4KIIIα protein complex is required for cell viability during Drosophila wing development

Author:
Basu, Urbashi; Balakrishnan, Sruthi S.; Janardan, Vishnu; Raghu, Padinjat
Source:
Developmental biology 2020 v.462 no.2 pp. 208-222
ISSN:
0012-1606
Subject:
cell viability,   etc   ; 1-phosphatidylinositol 4-kinase; Drosophila; apoptosis; caspases; metabolites; phosphates; plasma membrane;     Show all 8 Subjects
Abstract:
... Phosphatidylinositol 4 phosphate (PI4P) and phosphatidylinositol 4,5 bisphosphate [PI(4,5)P₂] are enriched on the inner leaflet of the plasma membrane and proposed to be key determinants of its function. PI4P is also the biochemical precursor for the synthesis of PI(4,5)P₂ but can itself also bind to and regulate protein function. However, the independent function of PI4P at the plasma membrane in ...
DOI:
10.1016/j.ydbio.2020.03.008

13. Astragalus polysaccharide exerts anti-Parkinson via activating the PI3K/AKT/mTOR pathway to increase cellular autophagy level in vitro

Author:
Tan, Yinyin; Yin, Ling; Sun, Zhanfang; Shao, Shanshan; Chen, Wenbin; Man, Xiao; Du, Yifeng; Chen, Yan
Source:
International journal of biological macromolecules 2020 v.153 pp. 349-356
ISSN:
0141-8130
Subject:
cell viability,   etc   ; Astragalus; autophagy; enzyme inhibition; models; phosphatidylinositol 3-kinase; polysaccharides; proteins;     Show all 8 Subjects
Abstract:
... Astragalus polysaccharide (APS) is a bioactive macromolecule, which has been used to alleviate the development of Parkinson's disease (PD), while its mechanism is still unresolved. As is generally accepted that autophagy has an important link with PD, thus it is reasonable to hypothesize that APS was involved in autophagy pathway for the presence of anti-PD. To verify this hypothesis, PD model was ...
DOI:
10.1016/j.ijbiomac.2020.02.282

14. High ErbB3 activating activity in human blood is not due to circulating neuregulin-1 beta

Author:
Boateng, Emmanuel; deKay, Joanne T.; Peterson, Sarah M.; Boles, Jacob; Pinnette, Nathan; Sorcher, Mary W.; Robich, Michael P.; Sawyer, Douglas B.; Ryzhov, Sergey
Source:
Life sciences 2020 v.251 pp. 117634
ISSN:
0024-3205
Subject:
cell viability,   etc   ; blood plasma; enzyme-linked immunosorbent assay; humans; inflammation; neutralizing antibodies; phosphorylation; receptors;     Show all 8 Subjects
Abstract:
... Neuregulin-1β (NRG-1) is a membrane-bound or secreted growth and differentiation factor that mediates its action by binding to ErbB receptors. Circulating levels of NRG-1 are characterized by large inter-individual variability with the range of absolute values covering two orders of magnitude, from hundreds to tens of thousands of picograms per milliliter of blood. NRG-1 signaling via ErbB recepto ...
DOI:
10.1016/j.lfs.2020.117634
PubMed:
32251632
PubMed Central:
PMC7233313

15. Effects of DCOIT (4,5-dichloro-2-octyl-4-isothiazolin-3-one) to the haemocytes of mussels Perna perna

Author:
Fonseca, Viviane Barneche; Guerreiro, Amanda da Silveira; Vargas, Marcelo Alves; Sandrini, Juliana Zomer
Source:
Comparative biochemistry and physiology 2020 v.232 pp. 108737
ISSN:
1532-0456
Subject:
cell viability,   etc   ; DNA damage; Perna perna; biocides; hemocytes; immune system; mussels; phagocytosis; pollutants; reactive oxygen species;     Show all 10 Subjects
Abstract:
... Bivalve molluscs rely only on an innate immune system to execute cellular and humoral processes. Haemocytes, the haemolymph circulating cells, play a major role in this type of immunity, principally regarding cellular defences. Considering that environmental pollutants can affect the immune system of invertebrates, this work evaluated the effects of the antifouling biocide 4,5-dicloro-2-n-octil-4- ...
DOI:
10.1016/j.cbpc.2020.108737

16. Interfacing human induced pluripotent stem cell-derived neurons with designed nanowire arrays as a future platform for medical applications

Author:
Harberts, Jann; Haferkamp, Undine; Haugg, Stefanie; Fendler, Cornelius; Lam, Dennis; Zierold, Robert; Pless, Ole; Blick, Robert H.
Source:
Biomaterials science 2020 v.8 no.9 pp. 2434-2446
ISSN:
2047-4849
Subject:
cell viability,   etc   ; action potentials; humans; medical equipment; models; nanowires; neurons; quality control; stem cells;     Show all 9 Subjects
Abstract:
... Nanostructured substrates such as nanowire arrays form a powerful tool for building next-generation medical devices. So far, human pluripotent stem cell-derived neurons—a revolutionary tool for studying physiological function and modeling neurodegenerative diseases—have not been applied to such innovative substrates, due to the highly demanding nature of stem cell quality control and directed diff ...
DOI:
10.1039/d0bm00182a

17. Synthesis and in vitro cytotoxic evaluation of spiro-β-lactone-γ-lactam scaffolds

Author:
Fábian, Martin; Gonda, Jozef; Jacková, Dominika; Martinková, Miroslava; Pilátová, Martina Bago; Jáger, Dávid
Source:
Tetrahedron 2020 v.76 no.18 pp. 131144
ISSN:
0040-4020
Subject:
cell viability,   etc   ; chemical bonding; chemical reactions; chemical structure; cytotoxicity; diastereoselectivity; lactones; neoplasm cells; pharmacology;     Show all 9 Subjects
Abstract:
... A successful approach to the construction of spiro-β-lactone-γ-lactam synthons 5 and ent-5 as a similar structural motif present in natural products such as oxazolomycins was developed. Two chirons, the protected 3-isothiocyanato-3-C-vinyl-α-d-xylofuranose and its antipode, were employed as the starting material. In order to obtain a lactone-pyrrolidine cyclic framework, a ring-closing metathesis, ...
DOI:
10.1016/j.tet.2020.131144

18. Photodynamic inactivation of Candida albicans and Candida tropicalis with aluminum phthalocyanine chloride nanoemulsion

Author:
Rodrigues, Gabriela Braga; Brancini, Guilherme Thomaz Pereira; Pinto, Marcelo Rodrigues; Primo, Fernando Lucas; Wainwright, Mark; Tedesco, Antonio Claudio; Braga, Gilberto Úbida Leite
Source:
Fungal biology 2020 v.124 no.5 pp. 297-303
ISSN:
1878-6146
Subject:
cell viability,   etc   ; Candida albicans; Candida tropicalis; chlorides; cytoplasm; fluorescence microscopy; fungi; nanoemulsions; organometallic compounds; photosensitivity;     Show all 10 Subjects
Abstract:
... The in vitro susceptibilities of Candida albicans and Candida tropicalis to Antimicrobial Photodynamic Treatment with aluminum phthalocyanine chloride in nanoemulsion (ClAlPc/NE) were investigated. PS concentration- and fluence-dependent cell survival after APDT were compared before and after unbound extracellular PS had been washed out. The PS uptake and its subcellular localization were also det ...
DOI:
10.1016/j.funbio.2019.08.004

19. Impact of the surface functionalization on nanodiamond biocompatibility: a comprehensive view on human blood immune cells

Author:
Fusco, Laura; Avitabile, Elisabetta; Armuzza, Valentina; Orecchioni, Marco; Istif, Akcan; Bedognetti, Davide; Da Ros, Tatiana; Delogu, Lucia Gemma
Source:
Carbon 2020 v.160 pp. 390-404
ISSN:
0008-6223
Subject:
cell viability,   etc   ; biocompatibility; carbon; carboxylic acids; cytokines; gene expression; humans; immune response; models; monocytes; nanodiamonds; secretion;     Show all 12 Subjects
Abstract:
... Nanodiamonds (NDs) represent a class of carbon nanostructures widely investigated as promising biomedical nanotools. The possible immune system reactions indicate success or failure for any nanosystem bioapplication. Moreover the assessment of the role of nanomaterial functionalization on the immune system response needs to be fully elucidated. We aimed to dissect the immunologic impact of two NDs ...
DOI:
10.1016/j.carbon.2020.01.003

20. Development of injectable and durable kefiran hydro-alcoholic gels

Author:
Sabatino, Maria Antonietta; Carfì Pavia, Francesco; Rigogliuso, Salvatrice; Giacomazza, Daniela; Ghersi, Giulio; La Carrubba, Vincenzo; Dispenza, Clelia
Source:
International journal of biological macromolecules 2020 v.149 pp. 309-319
ISSN:
0141-8130
Subject:
cell viability,   etc   ; cytotoxicity; drugs; gelation; gels; kefir; models; polymers; propylene glycol; syringes; temperature; tissue repair; viscosity;     Show all 13 Subjects
Abstract:
... Injectable, in-situ forming kefiran gels have been developed for potential applications as implantable drug delivery devices or scaffolds for tissue regeneration. Concentrated solutions (4, 5 and 6%w) of kefiran, extracted from kefir grains, have been assessed in term of viscosity and injectability through G26 syringe needles, and for their ability to undergo gelation upon mixing with different al ...
DOI:
10.1016/j.ijbiomac.2020.01.244