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1. Acid-facilitated G-quadruplex/hemin DNAzymes: accompanied by the assembly of quadruplex supramolecules

Author:
Cao, Yanwei; Li, Wenjing; Ding, Pi; Pei, Renjun
Source:
Chemical communications 2020 v.56 no.61 pp. 8667-8670
ISSN:
1364-548X
Subject:
chemical compounds,   etc   ; chemical reactions;     Show all 2 Subject
Abstract:
... Four types of quadruplex supramolecules containing G-quadruplex (G4)–I-motif interfaces were assembled under slightly acidic conditions, which can interact with hemin to form I-motif-linked G4/hemin DNAzymes. Our data demonstrated that some I-motif-linked DNAzymes are highly acid-dependent due to the stabilization of hemiprotonated cytosine–cytosine (C˙CH⁺) pairs for the G4 units. ...
DOI:
10.1039/d0cc03082a

2. A bicyclic unit reversal to stabilize the 12/14-helix in mixed homochiral oligoureas

Author:
Milbeo, Pierre; Simon, Matthieu; Didierjean, Claude; Wenger, Emmanuel; Aubert, Emmanuel; Martinez, Jean; Amblard, Muriel; Calmès, Monique; Legrand, Baptiste
Source:
Chemical communications 2020 v.56 no.57 pp. 7921-7924
ISSN:
1364-548X
Subject:
chemical compounds,   etc   ; chemical reactions;     Show all 2 Subject
Abstract:
... The insertion of cyclic building blocks in oligoureas to stabilize or modulate the properties of the 12/14-helix was often fruitless. We herein propose a fully compatible highly constrained building block that could be incorporated into oligoureas to develop highly stable and functional oligoureas helices. ...
DOI:
10.1039/d0cc02902e

3. Direct synthesis of 2-substituted benzonitriles via alkylcyanation of arynes with N,N-disubstituted aminomalononitriles

Author:
Bao, Wen; Gao, Zhu-Peng; Jin, Da-Ping; Xue, Cao-Gen; Liang, Huan; Lei, Ling-Sheng; Xu, Xue-Tao; Zhang, Kun; Wang, Shao-Hua
Source:
Chemical communications 2020 v.56 no.55 pp. 7641-7644
ISSN:
1364-548X
Subject:
chemical compounds,   etc   ; chemical reactions;     Show all 2 Subject
Abstract:
... An efficient alkylcyanation of in situ generated arynes by N,N-disubstituted aminomalononitriles is described, enabling the direct synthesis of 2-substituted benzonitriles. ...
DOI:
10.1039/d0cc01591a

4. Scaffold hopping enables direct access to more potent PROTACs with in vivo activity

Author:
Burslem, George M.; Bondeson, Daniel P.; Crews, Craig M.
Source:
Chemical communications 2020 v.56 no.50 pp. 6890-6892
ISSN:
1364-548X
Subject:
chemical compounds,   etc   ; chemical reactions;     Show all 2 Subject
Abstract:
... Herein we employ a scaffold hopping approach to enhance the activity of a previously reported BCR-Abl PROTAC. This represents a significant advance in the PROTAC field since it can abrogate the need to optimize the linker to access a more potent degrader. The new PROTAC demonstrates a >10 fold increase in ability to induce degradation and demonstrates in vivo activity. ...
DOI:
10.1039/d0cc02201b

5. Photo-regulated supramolecular star with a pillar[6]arene-coated metal–organic polyhedron (MOP) core

Author:
Hao, Xiang; Leng, Zejian; Sun, Dan; Peng, Feng; Yasin, Akram
Source:
Chemical communications 2020 v.56 no.49 pp. 6676-6679
ISSN:
1364-548X
Subject:
chemical compounds,   etc   ; chemical reactions;     Show all 2 Subject
Abstract:
... We herein report a 12-armed photo-responsive supramolecular star centered by a pillar[6]arene-coated M₆L₁₂ metal–organic polyhedron (MOP) via a core-first approach. ...
DOI:
10.1039/d0cc00536c

6. 3D deterministic lateral displacement (3D-DLD) cartridge system for high throughput particle sorting

Author:
Jusková, Petra; Matthys, Lionel; Viovy, Jean-Louis; Malaquin, Laurent
Source:
Chemical communications 2020 v.56 no.38 pp. 5190-5193
ISSN:
1364-548X
Subject:
chemical compounds,   etc   ; chemical reactions;     Show all 2 Subject
Abstract:
... A new 3D architecture for the deterministic lateral displacement (DLD) microfluidic devices based on ultra-high aspect ratio arch shaped pillars is presented. The proposed system addresses the major flow rate and shear rate limitations of standard planar devices. ...
DOI:
10.1039/c9cc05858c

7. A molten-salt protected pyrolysis approach for fabricating a ternary nickel–cobalt–iron oxide nanomesh catalyst with promoted oxygen-evolving performance

Author:
Xie, Junfeng; Guo, Yanqing; Lou, Shanshan; Wei, Zimeng; Hao, Pin; Lei, Fengcai; Tang, Bo
Source:
Chemical communications 2020 v.56 no.33 pp. 4579-4582
ISSN:
1364-548X
Subject:
chemical compounds,   etc   ; catalysts; pyrolysis;     Show all 3 Subjects
Abstract:
... In this work, a highly porous ternary NiCoFe oxide nanomesh with two-dimensional morphology and quasi-single-crystalline (QSC) feature was synthesized via a convenient molten-salt protected pyrolysis approach, which achieves remarkable OER performance with a low overpotential, high current density, improved intrinsic activity and superior operational stability. ...
DOI:
10.1039/d0cc01613f

8. A highly substituted pyrazinophane generated from a quinoidal system via a cascade reaction

Author:
Anderson, Christopher L.; Liang, Jiatao; Teat, Simon J.; Garzón-Ruiz, Andrés; Nenon, David P.; Navarro, Amparo; Liu, Yi
Source:
Chemical communications 2020 v.56 no.32 pp. 4472-4475
ISSN:
1364-548X
Subject:
chemical compounds,   etc   ; dimerization;     Show all 2 Subject
Abstract:
... The generation of a highly-substituted [2.2](2,5)pyrazinophane via a cascade reaction is presented. The pyrazinophane product is formed via the dimerization of a member of the para-azaquinodimethane (p-AQM) family of conjugated quinoidal compounds—reactivity that sheds light on the nature of stability in p-AQMs. Additionally, the electronic and structural nature of this highly-strained ring system ...
DOI:
10.1039/d0cc00916d

9. Diphenyl-1-pyrenylphosphine: photo-triggered AIE/ACQ transition with remarkable third-order nonlinear optical signal change

Author:
Xing, Chang; Liu, Jianxun; Chen, Fang; Li, Yuanyuan; Lv, Changjian; Peng, Qiuchen; Hou, Hongwei; Li, Kai
Source:
Chemical communications 2020 v.56 no.30 pp. 4220-4223
ISSN:
1364-548X
Subject:
chemical compounds,   etc   ; oxidation; phosphorus;     Show all 3 Subjects
Abstract:
... A propeller-like pyrene derivative of diphenyl-1-pyrenylphosphine (DPPP) is designed and synthesized. DPPP exhibits a unique photo-triggered AIE/ACQ transition with a remarkable third-order nonlinear optical signal change, which is proved to originate from the photo-induced oxidation of a phosphorus atom. ...
DOI:
10.1039/d0cc01031f

10. Multicolour fluorescent “sulfide–sulfone” diarylethenes with high photo-fatigue resistance

Author:
Uno, Kakishi; Bossi, Mariano L.; Belov, Vladimir N.; Irie, Masahiro; Hell, Stefan W.
Source:
Chemical communications 2020 v.56 no.14 pp. 2198-2201
ISSN:
1364-548X
Subject:
chemical compounds,   etc   ; fluorescence; oxidation;     Show all 3 Subjects
Abstract:
... Compact “push–pull” photochromic diaryethenes (DAEs) with unsymmetric oxidation pattern of the benzothiophene core display multicolour fluorescence switching, as a result of dual emission from both “open” and “closed” forms. These DAEs also present an unprecedented photo-fatigue resistance. ...
DOI:
10.1039/c9cc09390g

11. An unprecedented planar π-conjugated [B₂P₅]⁵⁻ group with ultra-large birefringence and nonlinearity: an ab initio study

Author:
Gong, Pifu; Zhang, Shengzi; Song, Gaomin; Liu, Xiaomeng; Lin, Zheshuai
Source:
Chemical communications 2020 v.56 no.4 pp. 643-646
ISSN:
1364-548X
Subject:
chemical compounds,   etc   ; chemical reactions;     Show all 2 Subject
Abstract:
... Searching for new nonlinear optical active (NLO-active) units would greatly promote the development of NLO materials. Herein, we theoretically investigate a newly reported [B₂P₅]⁵⁻ group which consisted of two corner-sharing [BP₃]³⁻ trigonal planar units. Attributed to the coplanar π-conjugated configuration and the unique connection mode, the [B₂P₅]⁵⁻ group can achieve both the largest birefringe ...
DOI:
10.1039/c9cc07019b

12. Competitive SPR using an intracellular anti-LMO2 antibody identifies novel LMO2-interacting compounds

Author:
Canning, Peter; Bataille, Carole; Bery, Nicolas; Milhas, Sabine; Hayes, Angela; Raynaud, Florence; Miller, Ami; Rabbitts, Terry
Source:
Journal of immunological methods 2021 v.494 pp. 113051
ISSN:
0022-1759
Subject:
chemical compounds,   etc   ; T-lymphocytes; antibodies; drugs; surface plasmon resonance;     Show all 5 Subjects
Abstract:
... The use of intracellular antibodies as templates to derive surrogate compounds is an important objective because intracellular antibodies can be employed initially for target validation in pre-clinical assays and subsequently employed in compound library screens. LMO2 is a T cell oncogenic protein activated in the majority of T cell acute leukaemias. We have used an inhibitory intracellular antibo ...
DOI:
10.1016/j.jim.2021.113051

13. Planar or tetrahedral? A ternary 17-electron CBe₅H₄⁺ cluster with planar pentacoordinate carbon

Author:
Guo, Jin-Chang; Feng, Lin-Yan; Barroso, Jorge; Merino, Gabriel; Zhai, Hua-Jin
Source:
Chemical communications 2020 v.56 no.59 pp. 8305-8308
ISSN:
1364-548X
Subject:
chemical compounds,   etc   ; carbon; chemical reactions;     Show all 3 Subjects
Abstract:
... A 17-electron CBe₅H₄⁺ cluster features planar pentacoordinate carbon, owing to the 2π/6σ double aromaticity. The neutral CBe₅H₄ cluster has a tetrahedral configuration despite its 18-electron counting. The latter species is governed by σ conjugation. ...
DOI:
10.1039/d0cc02973d

14. A facile method for generating worm-like micelles with controlled lengths and narrow polydispersity

Author:
Nahi, Ouassef; Cayre, Olivier J.; Kim, Yi-Yeoun; Smith, Andrew J.; Warren, Nicholas J.; Meldrum, Fiona C.
Source:
Chemical communications 2020 v.56 no.54 pp. 7463-7466
ISSN:
1364-548X
Subject:
chemical compounds,   etc   ; micelles; polymerization; sonication;     Show all 4 Subjects
Abstract:
... This work shows that highly uniform worm micelles formed by polymerisation induced self-assembly can be obtained via simple post-synthesis sonication. Importantly, this straightforward and versatile strategy yields exceptionally monodisperse worms with tunable aspect ratios ranging from 7.2 to 17.6 by simply changing the sonication time. ...
DOI:
10.1039/d0cc02313b

15. Homogeneous DNA-only keypad locks enable one-pot assay of multi-inputs

Author:
Wei, Bing; Sun, Xianbao; Yao, Dongbao; Li, Chengxu; Xiao, Shiyan; Guo, Yijun; Liang, Haojun
Source:
Chemical communications 2020 v.56 no.54 pp. 7427-7430
ISSN:
1364-548X
Subject:
chemical compounds,   etc   ; DNA; chemical reactions;     Show all 3 Subjects
Abstract:
... Homogeneous DNA-only keypad locks were built with multi-stranded scalable junction substrates and a series of double-stranded eliminators to differentially process correctly- and wrongly-added DNA inputs, respectively. Unlike conventional strategies that employed solid-phase platforms, one-pot assay of multiple DNA inputs was achieved, showing merits in fabricating complicated information security ...
DOI:
10.1039/d0cc02868a

16. Multi-modal control over the assembly of a molecular motor bola-amphiphile in water

Author:
Xu, Fan; Pfeifer, Lukas; Stuart, Marc C. A.; Leung, Franco King-Chi; Feringa, Ben L.
Source:
Chemical communications 2020 v.56 no.54 pp. 7451-7454
ISSN:
1364-548X
Subject:
chemical compounds,   etc   ; chemical reactions; pH;     Show all 3 Subjects
Abstract:
... We report multi-modal-control over the assembly behaviour of a first-generation molecular motor bola-amphiphile in water by light, pH and the choice of counter-ions. These findings open up opportunities for the development of materials that reconfigurate enabling complex functions in response to different stimuli. ...
DOI:
10.1039/d0cc02177f

17. Reduction of carbodiimides by a dialumane through insertion and cycloaddition

Author:
Xiao, Lin; Chen, Weixing; Shen, Lingyi; Liu, Li; Xue, Yujie; Zhao, Yanxia; Yang, Xiao-Juan
Source:
Chemical communications 2020 v.56 no.47 pp. 6352-6355
ISSN:
1364-548X
Subject:
chemical compounds,   etc   ; cycloaddition reactions; hydrogen;     Show all 3 Subjects
Abstract:
... The dialumane [L²⁻Alᴵᴵ–AlᴵᴵL²⁻] (L = [(2,6-iPr₂C₆H₃)NC(Me)]₂; 1) reacts with carbodiimides, RNCNR (R = Cy, iPr), through insertion, [2+4] cycloaddition, and a hydrogen transfer process. However, with the bulkier carbodiimides (R = dipp = 2,6-iPr₂C₆H₃, tBu), the reactions are sterically controlled and lead to the formamidinate products. ...
DOI:
10.1039/d0cc02048f

18. Correction: Synthesis of functionalized tetrahydropyrans via cascade cycloaddition involving silyloxyallyl cation intermediates

Author:
Badmus, Fatimat O.; Malone, Joshua A.; Fronczek, Frank R.; Kartika, Rendy
Source:
Chemical communications 2020 v.56 no.45 pp. 6154
ISSN:
1364-548X
Subject:
chemical compounds,   etc   ; cations; cycloaddition reactions;     Show all 3 Subjects
Abstract:
... Correction for ‘Synthesis of functionalized tetrahydropyrans via cascade cycloaddition involving silyloxyallyl cation intermediates’ by Fatimat O. Badmus et al., Chem. Commun., 2020, 56, 5034–5037, DOI: 10.1039/D0CC01796E. ...
DOI:
10.1039/d0cc90228d

19. Dipyridinoarsole: a new class of stable and modifiable heteroatom-bridged bipyridines

Author:
Fujii, Toshiki; Tanaka, Susumu; Hayashi, Shotaro; Imoto, Hiroaki; Naka, Kensuke
Source:
Chemical communications 2020 v.56 no.45 pp. 6035-6038
ISSN:
1364-548X
Subject:
chemical compounds,   etc   ; arsenic; nitrogen; oxidation;     Show all 4 Subjects
Abstract:
... Herein, we report our experimental and computational investigations on a stable and modifiable As-bridged dipyridinoheterole, dipyridinoarsole. Oxidation of the arsenic atom changes the frontier orbital energies and quaternization of nitrogen atoms produces electrochromic materials. Dipyridinoarsole is suitable for practical applications due to its superior stability compared to its phosphole anal ...
DOI:
10.1039/d0cc02389b

20. Remarkably enhanced proton conduction of {NBu₂(CH₂COOH)₂}[MnCr(ox)₃] by multiplication of carboxyl carrier in the cation

Author:
Ōkawa, Hisashi; Otsubo, Kazuya; Yoshida, Yukihiro; Kitagawa, Hiroshi
Source:
Chemical communications 2020 v.56 no.45 pp. 6138-6140
ISSN:
1364-548X
Subject:
chemical compounds,   etc   ; cations; chemical reactions;     Show all 3 Subjects
Abstract:
... The proton conduction of {NBu₂(CH₂COOH)₂}[MnCr(ox)₃] (dic-MnCr) is studied in comparison with its analogous {NBu₃(CH₂COOH)}[MnCr(ox)₃] (moc-MnCr). The proton conductivity is enhanced remarkably by the multiplication of the carboxyl carrier in the cation, from 5.2 × 10⁻⁷ S cm⁻¹ at 90% RH (25 °C) in moc-MnCr to 1.8 × 10⁻³ S cm⁻¹ at 95% RH (25 °C) in dic-MnCr. ...
DOI:
10.1039/d0cc02192j