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You searched for: Subject "chemokines" Remove constraint Subject: "chemokines"
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1. A novel strategy to investigate the factors regulating the Treg to Tfr transition during acute viral infection

Author:
Huayu Lin; Haoqiang Wang; Qiao Liu; Zhiming Wang; Shuqiong Wen; Lisha Wang; Junyi Guo; Ling Ran; Zhengliang Yue; Qing Wu; Jianfang Tang; Zhirong Li; Li Hu; Lifan Xu; Qizhao Huang; Lilin Ye
Source:
Journal of immunological methods 2022 v.505 pp. 113266
ISSN:
0022-1759
Subject:
chemokines,   etc   ; B-lymphocytes; homeostasis; lymph nodes;     Show all 4 Subjects
Abstract:
... Follicular regulatory T cells (Tfrs), a specialized subset of regulatory T cells (Tregs), have a particular role in the control of follicular helper T cell-driven germinal center (GC) responses. Following differentiation signals similar to those received by follicular helper T cells (Tfhs), Tfrs gain expression of characteristic chemokine receptors and transcription factors, such as CXCR5 and Bcl- ...
DOI:
10.1016/j.jim.2022.113266

2. Evolution of CCR5 and CCR2 Genes in Bats Showed Multiple Independent Gene Conversion Events

Author:
Alexandre P. Fernandes; Ana Águeda-Pinto; Ana Pinheiro; Hugo Rebelo; Pedro J. Esteves
Source:
Viruses 2022 v.14 no.2 pp. -
ISSN:
1999-4915
Subject:
chemokines,   etc   ; Miniopterus; Pteropodidae; evolution; gene conversion; genes; humans;     Show all 7 Subjects
Abstract:
... Chemokine receptors are an important determinant for the infectiousness of different pathogens, which are able to target the host cells by binding to the extracellular domains of these proteins. This is the mechanism of infection of HIV-1, among other concerning human diseases. Over the past years, it has been shown that two chemokine receptors, CCR2 and CCR5, have been shaped by events of gene co ...
DOI:
10.3390/v14020169

3. Neuron‐glia crosstalk in neuronal remodeling and degeneration: Neuronal signals inducing glial cell phagocytic transformation in Drosophila

Author:
Ana Boulanger; Jean‐Maurice Dura
Source:
BioEssays 2022 v.44 no.5 pp. e2100254
ISSN:
0265-9247
Subject:
chemokines,   etc   ; Drosophila; astrocytes; mushroom bodies; neurites; protein secretion;     Show all 6 Subjects
Abstract:
... Neuronal remodeling is a conserved mechanism that eliminates unwanted neurites and can include the loss of cell bodies. In these processes, a key role for glial cells in events from synaptic pruning to neuron elimination has been clearly identified in the last decades. Signals sent from dying neurons or neurites to be removed are received by appropriate glial cells. After receiving these signals, ...
DOI:
10.1002/bies.202100254

4. Nonrespiratory sites of influenza‐associated disease: mechanisms and experimental systems for continued study

Author:
Heather M. Froggatt; Nicholas S. Heaton
Source:
FEBS journal 2022 v.289 no.14 pp. 4038-4060
ISSN:
1742-464X
Subject:
chemokines,   etc   ; gastrointestinal system; human influenza; pathogenesis; respiratory system;     Show all 5 Subjects
Abstract:
... The productive replication of human influenza viruses is almost exclusively restricted to cells in the respiratory tract. However, a key aspect of the host response to viral infection is the production of inflammatory cytokines and chemokines that are not similarly tissue restricted. As such, circulating inflammatory mediators, as well as the resulting activated immune cells, can induce damage thr ...
DOI:
10.1111/febs.16363

5. A 33-color panel of phenotypic analysis of murine organ specific immune cells

Author:
Si-Yu Yang; Meng-Xing Huang; Yan-Xia Sun; Liang Li; Zhen-Hua Bian; Jie Long; Zhi-Bin Zhao
Source:
Journal of immunological methods 2022 v.507 pp. 113294
ISSN:
0022-1759
Subject:
chemokines,   etc   ; flow cytometry; immunophenotyping; liver; mice; permeability; phenotype; spleen;     Show all 8 Subjects
Abstract:
... This 33-color panel delineates immune phenotypes of the major lymphocyte subsets in murine tissues. The panel identifies surface markers for cell activation, differentiation, and exhaustion, and chemokine receptors, in CD4 T cells, CD8 T cells, γδ T cells, NK cells, NKT cells and B cells in spleen and liver. This panel was designed to include only surface markers to avoid the need for fixation and ...
DOI:
10.1016/j.jim.2022.113294

6. Targeting chemokine receptors from the inside-out: discovery and development of small-molecule intracellular antagonists

Author:
Margaux Billen; Dominique Schols; Peter Verwilst
Source:
Chemical communications 2022 v.58 no.26 pp. 4132-4148
ISSN:
1364-548X
Subject:
chemokines,   etc   ; X-radiation; antagonism; chemokine receptors; drugs; pharmaceutical industry;     Show all 6 Subjects
Abstract:
... Ever since the first biologically active chemokines were discovered in the late 1980s, these messenger proteins and their receptors have been the target for a plethora of drug discovery efforts in the pharmaceutical industry, as well as in academia. Owing to the publication of several chemokine receptor X-ray crystal structures, a highly druggable, intracellular, allosteric binding site which part ...
DOI:
10.1039/d1cc07080k

7. CXCL14-like chemokine in αMSH-producing cells and ACTH-producing cells in the pituitary of the Japanese eel

Author:
Hirohumi Suzuki; Kohta Takaoka; Toshiharu Yamamoto
Source:
Ichthyological research 2022 v.69 no.1 pp. 189-193
ISSN:
1341-8998
Subject:
chemokines,   etc   ; Anguilla japonica; corticotropin; energy metabolism; immunohistochemistry; insulin secretion; research;     Show all 7 Subjects
Abstract:
... This study provided the first analysis of the distribution of a CXCL14-like chemokine in the Japanese eel (Anguilla japonica) pituitary using immunohistochemical techniques. CXCL14-immnoreactive cells were observed in the rostral part of the pars distalis (RPD) and the pars intermedia (PI). The CXCL14-immunoreactive cells were found to correspond to adrenocorticotropic hormone (ACTH)-producing cel ...
DOI:
10.1007/s10228-021-00825-2

8. Modularisation of published and novel models toward a complex KIR2DL4 pathway in pbNK cell

Author:
Nurul Izza Ismail; Ana Masara Ahmad Mokhtar
Source:
MethodsX 2022 v.9 pp. 101760
ISSN:
2215-0161
Subject:
chemokines,   etc   ; amino acids; calcium; cytotoxins; data collection; databases; ligands; mathematical models; secretion;     Show all 9 Subjects
Abstract:
... KIR2DL4 is an interesting receptor expressed on the peripheral blood natural killer (pbNK) cell as it can be either activating or inhibitory depending on the amino acid residues in the domain. This model uses mathematical modelling to investigate the downstream effects of natural killer cells’ activation (KIR2DL4) receptor after stimulation by key ligand (HLA-G) on pbNK cells. Development of this ...
DOI:
10.1016/j.mex.2022.101760

9. Transcriptomic profiling revealed the role of apigenin-4′-O-α-L-rhamnoside in inhibiting the activation of rheumatoid arthritis fibroblast-like synoviocytes via MAPK signaling pathway

Author:
Dan Cao; Qiqi Fan; Zhiqi Li; Meilin Chen; Yangyu Jiang; Ruichao Lin; Jian Li; Chongjun Zhao
Source:
Phytomedicine 2022 v.102 pp. 154201
ISSN:
0944-7113
Subject:
chemokines,   etc   ; Western blotting; cell viability; pathogenesis; pharmacology; rats; rheumatoid arthritis; therapeutics; transcriptomics;     Show all 9 Subjects
Abstract:
... Activated fibroblast-like synoviocyte (FLS) played a significant role in the pathogenesis and progression of rheumatoid arthritis (RA). Apigenin-4′-O-α-L-rhamnoside showed remarkable effects against RA, however, no relevant studies on pharmacology of apigenin-4′-O-α-L-rhamnoside yet, the effects and underlying molecular mechanism of apigenin-4′-O-α-L-rhamnoside on RA are still unclear. This study ...
DOI:
10.1016/j.phymed.2022.154201

10. The danger signal interferon-induced protein 35 (IFP35) mediates acetaminophen-induced liver injury

Author:
Xiating Mao; Danning Wu; Na Xu; Jingjing Wang; Jinhua Zeng; Zhiqiang Jiang; Yingfang Liu; Huanhuan Liang
Source:
Biochemical and biophysical research communications 2022 v.621 pp. 25-31
ISSN:
0006-291X
Subject:
chemokines,   etc   ; acetaminophen; antibodies; hepatocytes; inflammation; liver; liver failure; neutrophils; overdose; research; toxicity;     Show all 11 Subjects
Abstract:
... Acute liver injury caused by overdose usage of acetaminophen (APAP) is an intractable clinical problem. Necrotic hepatocytes release large amounts of intracellular components including damage-associated molecular patterns (DAMPs) which contribute to liver failure and may serve as therapeutic targets. However, the pathogenic mechanisms of DAMPs in APAP-induced liver injury (AILI) are remain largely ...
DOI:
10.1016/j.bbrc.2022.06.086

11. Transcriptomics analysis reveals key lncRNAs and genes related to the infection of porcine lung macrophages by Glaesserella parasuis

Author:
Yuan Y. Zhou; Jing Yuan; Yong C. Jia; Ying Guo; Rong L. Yin; Zhong B. Guo; Jing Y. Wang; Chao Wang; Rong H. Yin
Source:
Microbial pathogenesis 2022 v.169 pp. 105617
ISSN:
0882-4010
Subject:
chemokines,   etc   ; adhesion; bacterial infections; inflammation; lungs; macrophages; microRNA; pathogenesis; pathogens; serotypes; swine; transcriptomics;     Show all 12 Subjects
Abstract:
... Glaesserella parasuis (G. parasuis) is the pathogen of Glässer's disease in pig herds, which can cause severe inflammatory responses. However, at present, the pathogenic mechanism of G. parasuis is not very clear. LncRNAs can regulate the expression of mRNA in a variety of ways, thereby causing host cells to produce a variety of functional changes in response to bacterial infection. Here, we detec ...
DOI:
10.1016/j.micpath.2022.105617

12. Gene expression data of inflammatory mediators in apical periodontitis in 129 (wild type) and 5-lipoxygenase knockout mice

Author:
Thaise Mayumi Taira; Vítor Luís Ribeiro; Yuri Jivago Silva Ribeiro; Raquel Assed Bezerra da Silva; Léa Assed Bezerra da Silva; Marília Pacífico Lucisano Politi; Lúcia Helena Faccioli; Francisco Wanderley Garcia Paula-Silva
Source:
Data in Brief 2022 v.40 pp. 107787
ISSN:
2352-3409
Subject:
chemokines,   etc   ; bone formation; bone resorption; enzymes; gene expression; gene targeting; inflammation; osteoclasts; periodontitis;     Show all 9 Subjects
Abstract:
... Apical periodontitis is an immune inflammatory response around periapical tissues as a result of pathogens invasion into the root canal. The host immunoinflammatory response could determine the progression of this disease, which involves the recruitment of immune cells, and the release of several cytokines in the lesion site. The 5-lipoxygenase pathway has been activated in some osteolytic disease ...
DOI:
10.1016/j.dib.2021.107787

13. Contact-dependent signaling triggers tumor-like proliferation of CCM3 knockout endothelial cells in co-culture with wild-type cells

Author:
Matthias Rath; Konrad Schwefel; Matteo Malinverno; Dariush Skowronek; Alexandra Leopoldi; Robin A. Pilz; Doreen Biedenweg; Sander Bekeschus; Josef M. Penninger; Elisabetta Dejana; Ute Felbor
Source:
Cellular and molecular life sciences 2022 v.79 no.6 pp. 340
ISSN:
1420-682X
Subject:
chemokines,   etc   ; RNA; antineoplastic agents; coculture; drug development; endothelial cells; germ cells; humans; mutants; organoids;     Show all 10 Subjects
Abstract:
... Cerebral cavernous malformations (CCM) are low-flow vascular lesions prone to cause severe hemorrhage-associated neurological complications. Pathogenic germline variants in CCM1, CCM2, or CCM3 can be identified in nearly 100% of CCM patients with a positive family history. In line with the concept that tumor-like mechanisms are involved in CCM formation and growth, we here demonstrate an abnormall ...
DOI:
10.1007/s00018-022-04355-6

14. Differential Pathogenesis of SARS-CoV-2 Variants of Concern in Human ACE2-Expressing Mice

Author:
Janhavi Prasad Natekar; Heather Pathak; Shannon Stone; Pratima Kumari; Shaligram Sharma; Tabassum Tasnim Auroni; Komal Arora; Hussin Alwan Rothan; Mukesh Kumar
Source:
Viruses 2022 v.14 no.6 pp. -
ISSN:
1999-4915
Subject:
chemokines,   etc   ; Severe acute respiratory syndrome coronavirus 2; brain; humans; pandemic; pathogenesis; survival rate; viruses;     Show all 8 Subjects
Abstract:
... Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the current pandemic, resulting in millions of deaths worldwide. Increasingly contagious variants of concern (VoC) have fueled recurring global infection waves. A major question is the relative severity of the disease caused by previous and currently circulating variants of SARS-CoV-2. In this study, we evaluated the pathogene ...
DOI:
10.3390/v14061139

15. Dendrimer as a momentous tool in tissue engineering and regenerative medicine

Author:
Aazam Shaikh; Prashant Kesharwani; Virendra Gajbhiye
Source:
Journal of controlled release 2022 v.346 pp. 328-354
ISSN:
0168-3659
Subject:
chemokines,   etc   ; biocompatibility; bone formation; cartilage; cornea; crosslinking; dendrimers; extracellular matrix; medicine; metabolites; microRNA; transfection;     Show all 12 Subjects
Abstract:
... Dendrimers have been comprehensively used for cargo delivery, nucleic acid delivery (genes, miRNA/siRNAs), delivery of macromolecules, and other various biomedical applications. Dendrimers are highly versatile in function and can be engineered as multifunctional biomacromolecules by modifying the surface for fulfilling different applications. Dendrimers are being used for crosslinking of existing ...
DOI:
10.1016/j.jconrel.2022.04.008

16. Self-powered smart patch promotes skin nerve regeneration and sensation restoration by delivering biological-electrical signals in program

Author:
Min-hong Tan; Xue-han Xu; Tie-jun Yuan; Xu Hou; Jie Wang; Zhi-hong Jiang; Li-hua Peng
Source:
Biomaterials 2022 v.283 pp. 121413
ISSN:
0142-9612
Subject:
chemokines,   etc   ; biocompatible materials; compliance; electrodes; energy; exosomes; gels; nerve regeneration; nerve tissue; neurons; sensation; therapeutics;     Show all 12 Subjects
Abstract:
... Skin wound is always accompanied with nerve destruction. Due to the limited clinical treatment option, loss of skin sensation with unsatisfactory nerve regeneration is remained to be a challenge for wound therapy. Endogenous mesenchymal stem cells (MSCs) based in situ regeneration, of which, MSCs recruited by chemokines and directed for neuronal differentiation by biological and electrical signals ...
DOI:
10.1016/j.biomaterials.2022.121413

17. Glycosaminoglycan-Based Hydrogel Delivery System Regulates the Wound Microenvironment to Rescue Chronic Wound Healing

Author:
Xiang Zhang; Jin Feng; Weina Feng; Buxuan Xu; Kai Zhang; Guiping Ma; Yang Li; Maowei Yang; Fu-Jian Xu
Source:
ACS applied materials & interfaces 2022 v.14 no.28 pp. 31737-31750
ISSN:
1944-8252
Subject:
chemokines,   etc   ; anti-inflammatory activity; antioxidants; crosslinking; curcumin; drugs; heparin; hyaluronic acid; hydrogels; hydrophobicity; inflammation; therapeutics;     Show all 12 Subjects
Abstract:
... Chronic wounds cannot proceed through the normal, orderly, and timely sequence of repair. The adverse cycle between excess reactive oxide species (ROS) and a persistent inflammatory response is an important mechanism of impaired wound healing. Herein, by combining the intrinsic bioactivities of natural polysaccharides and natural drugs, a glycosaminoglycan-based hydrogel delivery system is propose ...
DOI:
10.1021/acsami.2c08593

18. HIV-1 Accessory Proteins Impart a Modest Interferon Response and Upregulate Cell Cycle-Related Genes in Macrophages

Author:
Laura J. Martins; Matthew A. Szaniawski; Elizabeth S. C. P. Williams; Mayte Coiras; Timothy M. Hanley; Vicente Planelles
Source:
Pathogens 2022 v.11 no.2 pp. -
ISSN:
2076-0817
Subject:
chemokines,   etc   ; HIV infections; RNA; immune response; interferons; macrophages; mitosis; people; therapeutics; transcription (genetics); transcriptome; transcriptomics;     Show all 12 Subjects
Abstract:
... HIV-1 infection of myeloid cells is associated with the induction of an IFN response. How HIV-1 manipulates and subverts the IFN response is of key interest for the design of therapeutics to improve immune function and mitigate immune dysregulation in people living with HIV. HIV-1 accessory genes function to improve viral fitness by altering host pathways in ways that enable transmission to occur ...
DOI:
10.3390/pathogens11020163

19. Deciphering the role of damage-associated molecular patterns and inflammatory responses in acute lung injury

Author:
Po-Chun Hsieh; Yao-Kuang Wu; Mei-Chen Yang; Wen-Lin Su; Chan-Yen Kuo; Chou-Chin Lan
Source:
Life sciences 2022 v.305 pp. 120782
ISSN:
0024-3205
Subject:
chemokines,   etc   ; adaptive immunity; adhesion; cell death; endothelium; inflammasomes; lungs; macrophages; mitochondria; mortality; neutrophils; pathogenesis; proteinases;     Show all 13 Subjects
Abstract:
... Acute lung injury (ALI) is characterized by diffuse pulmonary infiltrates and causes great mortality. ALI presents with overproduction of proinflammatory cytokines, cell death, destruction of alveoli-endothelial barriers, and neutrophil infiltration in lung tissues. Damage-associated molecular patterns (DAMPs) are molecules released from damaged cells due to infection, trauma, etc. DAMPs activate ...
DOI:
10.1016/j.lfs.2022.120782

20. Renal tubular PAR2 promotes interstitial fibrosis by increasing inflammatory responses and EMT process

Author:
Sugyeong Ha; Ki Wung Chung; Jaewon Lee; Hae Young Chung; Hyung Ryong Moon
Source:
Archives of pharmacal research 2022 v.45 no.3 pp. 159-173
ISSN:
0253-6269
Subject:
chemokines,   etc   ; adenine; agonists; epithelium; extracellular matrix; fibrosis; inflammation; macrophages; mice; renal function; renal tubules; research;     Show all 12 Subjects
Abstract:
... Renal fibrosis is defined by excessive extracellular matrix (ECM) accumulation and is associated with a decreased kidney function. Increased inflammation and infiltration of inflammatory cells are the key features of renal fibrosis development; however, the mechanism of how inflammation starts is still un-known. Here, we show that the activation of epithelial Protease-activating receptor 2 (PAR2) ...
DOI:
10.1007/s12272-022-01375-5