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1. Chemokines and their receptors promoting the recruitment of myeloid-derived suppressor cells into the tumor

Author:
Li, Bao-Hua; Garstka, Malgorzata A.; Li, Zong-Fang
Source:
Molecular immunology 2020 v.117 pp. 201-215
ISSN:
0161-5890
Subject:
chemokine CCL2; chemokine CCL3; chemokine CX3CL1,   etc   ; bone marrow; chemokine CXCL5; cyclin-dependent kinase; drug therapy; immune response; immunotherapy; metastasis; neoplasms; prognosis; receptors; signal transduction; suppressor cells;     Show all 15 Subjects
Abstract:
... Myeloid-derived suppressor cells (MDSCs) expand in tumor-bearing host. They suppress anti-tumor immune response and promote tumor growth. Chemokines play a vital role in recruiting MDSCs into tumor tissue. They can also induce the generation of MDSCs in the bone marrow, maintain their suppressive activity, and promote their proliferation and differentiation. Here, we review CCL2/CCL12-CCR2, CCL3/4 ...
DOI:
10.1016/j.molimm.2019.11.014

2. A comparative study on the mechanisms of innate immune responses in mice induced by Alum and Actinidia eriantha polysaccharide

Author:
Du, Jing; Chen, Xiangfeng; Ye, Yiping; Sun, Hongxiang
Source:
International journal of biological macromolecules 2020 v.156 pp. 1202-1216
ISSN:
0141-8130
Subject:
chemokine CCL2; chemokine CCL3; chemokine CCL4,   etc   ; Actinidia eriantha; adjuvants; alum; chemokine CCL7; chemokine CXCL10; chemokine CXCL2; chemokine CXCL3; chemokine CXCL5; comparative study; dendritic cells; eosinophils; gene expression; gene expression regulation; genes; immune response; innate immunity; interleukin-17; messenger RNA; mice; microarray technology; monocytes; neutrophils; non-coding RNA; polysaccharides; vaccines;     Show all 28 Subjects
Abstract:
... The innate immune mechanisms by which adjuvants enhance the potency and protection of vaccine remain at cellular level, but the molecular mechanisms, especially in vivo, are ill-identified. Actinidia eriantha polysaccharide (AEPS) is a potent adjuvant with dual Th1 and Th2 potentiating activity, while Alum elicits a strict Th2 response. The current experiments were designed to compare the innate i ...
DOI:
10.1016/j.ijbiomac.2019.11.158

3. Standardized protocols for differentiation of THP-1 cells to macrophages with distinct M(IFNγ+LPS), M(IL-4) and M(IL-10) phenotypes

Author:
Baxter, E.W.; Graham, A.E.; Re, N.A.; Carr, I.M.; Robinson, J.I.; Mackie, S.L.; Morgan, A.W.
Source:
Journal of immunological methods 2020 v.478 pp. 112721
ISSN:
0022-1759
Subject:
chemokine CCL17; chemokine CCL26,   etc   ; humans; interleukin-10; interleukin-4; macrophages; models; phenotype;     Show all 8 Subjects
Abstract:
... In vitro models of differing macrophage functions are useful since human monocyte–derived macrophages are short–lived, finite and vary from donor to donor. Published protocols using the promonocytic cell line THP-1 have tended to result in cells that closely resemble classically-activated macrophages, differentiated in IFNγ and LPS. However, no protocol, to date, has fully recapitulated polarizati ...
DOI:
10.1016/j.jim.2019.112721

4. Differential regulatory effects of chemotherapeutic protocol on CCL3_CCL4_CCL5/CCR5 axes in acute myeloid leukemia patients with monocytic lineage

Author:
Yazdani, Zinat; Mousavi, Zahra; Ghasemimehr, Narges; Kalantary Khandany, Behjat; Nikbakht, Roya; Jafari, Elham; Fatemi, Ahmad; Hassanshahi, Gholamhossein
Source:
Life sciences 2020 v.240 pp. 117071
ISSN:
0024-3205
Subject:
chemokine CCL3; chemokine CCL4; chemokine CCL5,   etc   ; CCR5 receptor; blood serum; bone marrow; drug therapy; flow cytometry; ligands; lymphocytes; myeloid leukemia; patients;     Show all 12 Subjects
Abstract:
... AML (Acute myeloid leukemia) is characterized as a heterogeneous cancer. Chemokines play fundamental roles in the onset, progression cellular, migration, survival and improvement of AML therapy outcomes. The CCR5 receptors together with their ligands have indirect effects on the progression of cancer. In the present study, we have decided to investigate the impact of chemotherapy on the expression ...
DOI:
10.1016/j.lfs.2019.117071

5. Emerging Insights into the Structure and Function of Complement C5a Receptors

Author:
Pandey, Shubhi; Maharana, Jagannath; Li, Xaria X.; Woodruff, Trent M.; Shukla, Arun K.
Source:
Trends in biochemical sciences 2020 v.45 no.8 pp. 693-705
ISSN:
0968-0004
Subject:
chemokine receptors,   etc   ; G-proteins; agonists; arrestins; complement; innate immunity;     Show all 6 Subjects
Abstract:
... Complement factor C5a is an integral constituent of the complement cascade critically involved in the innate immune response, and it exerts its functions via two distinct receptors, C5aR1 and C5aR2. While C5aR1 is a prototypical G-protein-coupled receptor (GPCR), C5aR2 lacks functional coupling to heterotrimeric G proteins, although both receptors efficiently recruit β arrestins (βarrs). Here, we ...
DOI:
10.1016/j.tibs.2020.04.004

6. CXCL12/CXCR4 axis in the microenvironment of solid tumors: A critical mediator of metastasis

Author:
Mortezaee, Keywan
Source:
Life sciences 2020 v.249 pp. 117534
ISSN:
0024-3205
Subject:
chemokine CXCL12,   etc   ; CXCR4 receptor; ligands; metastasis; neoplasm progression; neoplasms;     Show all 6 Subjects
Abstract:
... Tumors are dynamic tissue masses, so requiring continuous exposure to the host cells, nurturing them into pave a path for tumor growth and metastasis. C-X-C chemokine ligand 12 (CXCL12)/C-X-C chemokine receptor type 4 (CXCR4) is the key signaling for such aim. Gathering knowledge about the activity within this axis would deepen our insight into the utmost importance this signaling taken to attract ...
DOI:
10.1016/j.lfs.2020.117534

7. Integrative Model to Coordinate the Oligomerization and Aggregation Mechanisms of CCL5

Author:
Chen, Yi-Chen; Chen, Siou-Pei; Li, Jin-Ye; Chen, Pei-Chun; Lee, Yi-Zong; Li, Kun-Mou; Zarivach, Raz; Sun, Yuh-Ju; Sue, Shih-Che
Source:
Journal of molecular biology 2020 v.432 no.4 pp. 1143-1157
ISSN:
0022-2836
Subject:
chemokine CCL5,   etc   ; models; mutants; nuclear magnetic resonance spectroscopy; oligomerization; pathogenesis;     Show all 6 Subjects
Abstract:
... CC-type chemokine ligand 5 (CCL5) is involved in the pathogenesis of many inflammatory conditions. Under physiological conditions, CCL5 oligomerization and aggregation are considered to be responsible for its inflammatory properties. The structural basis of CCL5 oligomerization remains controversial because the current oligomer models contain no consensus interactions. In this study, NMR and bioph ...
DOI:
10.1016/j.jmb.2019.12.049

8. Biomarkers of cell-mediated immunity to bovine tuberculosis

Author:
Palmer, Mitchell V.; Thacker, Tyler C.; Rabideau, Meaghan M.; Jones, Gareth J.; Kanipe, Carly; Vordermeier, H. Martin; Ray Waters, W.
Source:
Veterinary immunology and immunopathology 2020 v.220 pp. 109988
ISSN:
0165-2427
Subject:
chemokine CCL2; chemokine CCL3; chemokine CXCL10,   etc   ; Mycobacterium bovis; aerosols; biomarkers; blood; bovine tuberculosis; cattle; cell-mediated immunity; chemokine CXCL9; gene expression; human diseases; interferon-gamma; interleukin-13; interleukin-1alpha; interleukin-1beta; interleukin-21; protein content; tumor necrosis factor-alpha;     Show all 20 Subjects
Abstract:
... Whole blood based assays, particularly interferon gamma (IFN-γ) release assays (IGRAs), are used for the diagnosis of both bovine and human tuberculosis (TB). The aim of the current study was to evaluate a panel of cytokines and chemokines for potential use as diagnostic readouts indicative of Mycobacterium bovis (M. bovis) infection in cattle. A gene expression assay was used to determine the kin ...
DOI:
10.1016/j.vetimm.2019.109988

9. The effects of CCL3, CCL4, CCL19 and CCL21 as molecular adjuvants on the immune response to VAA DNA vaccine in flounder (Paralichthys olivaceus)

Author:
Xu, Hongsen; Xing, Jing; Tang, Xiaoqian; Sheng, Xiuzhen; Zhan, Wenbin
Source:
Developmental and comparative immunology 2020 v.103 pp. 103492
ISSN:
0145-305X
Subject:
chemokine CCL19; chemokine CCL21; chemokine CCL3,   etc   ; Paralichthys olivaceus; Vibrio anguillarum; adjuvants; antibodies; antigen-presenting cells; chemokine CCL4; flounder; gene expression; gene expression regulation; genes; immune response; injection site; kidneys; liver; lymphocytes; plasmids; recombinant vaccines; spleen;     Show all 21 Subjects
Abstract:
... The magnitude of the immune response induced by DNA vaccines depends on the amount and type of antigen-presenting cells attracted to the injection site. In our previous study, a DNA plasmid encoding the VAA gene of Vibrio anguillarum was constructed and shown to confer moderate protection against V. anguillarum challenge. To augment the protective efficacy of the VAA DNA vaccine and compare the ad ...
DOI:
10.1016/j.dci.2019.103492

10. A human embryonic stem cell-based in vitro model revealed that ultrafine carbon particles may cause skin inflammation and psoriasis

Author:
Cheng, Zhanwen; Liang, Xiaoxing; Liang, Shaojun; Yin, Nuoya; Faiola, Francesco
Source:
Journal of environmental sciences (China) 2020 v.87 pp. 194-204
ISSN:
1001-0742
Subject:
chemokine CCL20; chemokine CXCL1; chemokine CXCL2,   etc   ; air pollution; blood flow; carbon; chemokine CXCL3; children; developmental toxicity; embryonic stem cells; gene expression regulation; genes; inflammation; interleukin-1beta; interleukin-6; interleukin-8; keratinocytes; lungs; models; pollutants; psoriasis;     Show all 21 Subjects
Abstract:
... Air pollution has been linked to many health issues, including skin conditions, especially in children. Among all the atmospheric pollutants, ultrafine particles have been deemed very dangerous since they can readily penetrate the lungs and skin, and be absorbed into the bloodstream. Here, we employed a human embryonic stem cell (hESC)-based differentiation system towards keratinocytes, to test th ...
DOI:
10.1016/j.jes.2019.06.016

11. Evasins: Tick Salivary Proteins that Inhibit Mammalian Chemokines

Author:
Bhusal, Ram Prasad; Eaton, James R.O.; Chowdhury, Sayeeda T.; Power, Christine A.; Proudfoot, Amanda E.I.; Stone, Martin J.; Bhattacharya, Shoumo
Source:
Trends in biochemical sciences 2020 v.45 no.2 pp. 108-122
ISSN:
0968-0004
Subject:
chemokine receptors; chemokines,   etc   ; Arachnida; animal models; anti-inflammatory agents; blood flow; engineering; glycoproteins; hosts; inflammation; leukocytes; mammals; parasitism; therapeutics; ticks;     Show all 15 Subjects
Abstract:
... Ticks are hematophagous arachnids that parasitize mammals and other hosts, feeding on their blood. Ticks secrete numerous salivary factors that enhance host blood flow or suppress the host inflammatory response. The recruitment of leukocytes, a hallmark of inflammation, is regulated by chemokines, which activate chemokine receptors on the leukocytes. Ticks target this process by secreting glycopro ...
DOI:
10.1016/j.tibs.2019.10.003

12. Transcriptome sequencing analysis of porcine MDM response to FSL-1 stimulation

Author:
Zhou, Lisheng; Wang, Li; Zhao, Weimin; Ren, Shouwen; Tu, Feng; Fu, Yanfeng; Li, Bixia; Wang, Xuemin; Fang, Xiaomin
Source:
Microbial pathogenesis 2020 v.138 pp. 103830
ISSN:
0882-4010
Subject:
chemokine CCL2; chemokine CCL4; chemokine CCL5,   etc   ; Mycoplasma; Toll-like receptor 2; chemokine CXCL10; chemokine CXCL2; financial economics; gene expression; gene expression regulation; genes; host-pathogen relationships; immune response; inflammation; innate immunity; interleukin-6; interleukin-8; lipopeptides; macrophages; metabolism; models; mycoplasmosis; pathogenesis; pork; sequence analysis; signal transduction; swine; transcription (genetics); transcriptomics; tumor necrosis factors;     Show all 30 Subjects
Abstract:
... Mycoplasma infection can cause many diseases in pigs, resulting in great economic losses in pork production. Innate immune responses are thought to play critical roles in the pathogenesis of mycoplasma disease. However, the molecular events involved in immune responses remain to be determined. Hence, the object of this study was to use RNA-Seq to investigate the gene expression profiles of the inn ...
DOI:
10.1016/j.micpath.2019.103830

13. Receptor and signaling pathway involved in bovine lymphocyte activation by Atractylodis macrocephalae polysaccharides

Author:
Xu, Wei; Fang, Sijia; Wang, Yong; Chi, Xiaoqing; Ma, Xiaodan; Zhang, Tao; Hu, Songhua
Source:
Carbohydrate polymers 2020 v.234 pp. 115906
ISSN:
0144-8617
Subject:
chemokine CCL4; chemokine CXCL10; chemokine CXCL9,   etc   ; B-lymphocytes; Western blotting; calcium signaling; cattle; gene expression regulation; genes; interferon-alpha; interferon-gamma; interleukin-1alpha; interleukin-21; lymphocyte proliferation; microRNA; mitogen-activated protein kinase; polysaccharides; secretion; sequence analysis;     Show all 19 Subjects
Abstract:
... The present study was to investigate the molecular mechanism underlying lymphocyte activation by total polysaccharides from Atractylodis macrocephalae (RAMPtp). The results showed that RAMPtp significantly promoted the secretions of cytokines (IFN-γ, IL-1α, IL-21, IFN-α, CCL4, CXCL9 and CXCL10), increased the proportions of CD4⁺ and CD8⁺ subpopulations, and enhanced the expressions of c-JUN, NFAT4 ...
DOI:
10.1016/j.carbpol.2020.115906

14. West Nile Virus spread and differential chemokine response in the central nervous system of mice: Role in pathogenic mechanisms of encephalitis

Author:
Vidaña, Beatriz; Johnson, Nicholas; Fooks, Anthony R.; Sánchez‐Cordón, Pedro J.; Hicks, Daniel J.; Nuñez, Alejandro
Source:
Transboundary and emerging diseases 2020 v.67 no.2 pp. 799-810
ISSN:
1865-1674
Subject:
chemokine CCL2; chemokine CCL5; chemokine CXCL10,   etc   ; West Nile virus; astrocytes; birds; brain; cortex; emerging diseases; encephalitis; endothelial cells; histology; horses; immune response; leukocytes; models; nerve tissue; neurons; pathogenesis; viral antigens; viruses; zoonoses;     Show all 22 Subjects
Abstract:
... West Nile virus (WNV) is a zoonotic mosquito‐borne flavivirus able to cause severe neurological disease in humans, horses and various avian species. The more severe pathological changes of neurotropic WNV infection are caused by virus neuroinvasion and/or the immunological response in the central nervous system (CNS). The extent in which inflammatory cell trafficking orchestrated by chemokines is ...
DOI:
10.1111/tbed.13401

15. A high-throughput chemotaxis detection method for CCR4+ T cell migration inhibition using image cytometry

Author:
Magnotti, Elizabeth L.; Chan, Leo Li-Ying; Zhu, Quan; Marasco, Wayne A.
Source:
Journal of immunological methods 2020 v.479 pp. 112747
ISSN:
0022-1759
Subject:
chemokine CCL17; chemokine CCL22,   etc   ; T-lymphocytes; antibodies; cell movement; chemotaxis; dose response; flow cytometry; high-throughput screening methods; immunity; immunotherapy; ligands; neoplasms; screening;     Show all 14 Subjects
Abstract:
... Chemotaxis is an important aspect of immune cell behavior within the tumor microenvironment (TME). One prominent example of chemotaxis within the TME is the migration of regulatory T cells (Tregs) in response to the chemokine ligands CCL17 and CCL22. Tregs within the TME cause the suppression of anti-tumor immunity and inhibition of the effect of immunotherapeutic treatments. Therefore, the abilit ...
DOI:
10.1016/j.jim.2020.112747

16. Effect of the Antimicrobial Peptide LL-37 on Gene Expression of Chemokines and 29 Toll-like Receptor-Associated Proteins in Human Gingival Fibroblasts Under Stimulation with Porphyromonas gingivalis Lipopolysaccharide

Author:
Inomata, Megumi; Horie, Toshi; Into, Takeshi
Source:
Probiotics and antimicrobial proteins 2020 v.12 no.1 pp. 64-72
ISSN:
1867-1306
Subject:
chemokine CCL2; chemokine CXCL10,   etc   ; Porphyromonas gingivalis; Toll-like receptor 4; antagonists; antimicrobial peptides; cytotoxicity; fibroblasts; gene expression; gene expression regulation; genes; humans; interleukin-8; ligands; lipopolysaccharides; neutralization;     Show all 16 Subjects
Abstract:
... The antimicrobial peptide LL-37 neutralizes the biological activity of lipopolysaccharide (LPS), while it upregulates the expression of several immune-related genes. We investigated the effect of LL-37 on gene regulation of human gingival fibroblasts (HGFs), stimulated with or without Porphyromonas gingivalis-derived LPS, a ligand for Toll-like receptor (TLR). LL-37 was non-toxic to HGFs up to a c ...
DOI:
10.1007/s12602-019-09600-2

17. Targeting of HA to chemokine receptors induces strong and cross-reactive T cell responses after DNA vaccination in pigs

Author:
Grodeland, Gunnveig; Fossum, Even; Bogen, Bjarne
Source:
Vaccine 2020 v.38 no.6 pp. 1280-1285
ISSN:
0264-410X
Subject:
chemokine receptors; chemokines,   etc   ; DNA; Orthomyxoviridae; T-lymphocytes; antibodies; antigen-presenting cells; hemagglutinins; human population; immunoglobulin G; influenza; influenza vaccination; pandemic; pork industry; recombinant vaccines; risk; swine;     Show all 17 Subjects
Abstract:
... Efficient influenza vaccination of pigs can reduce disease burdens for the swine industry, but also represents an important measure for reducing the risk from novel viral reassortments that pose pandemic threats to the human population. Here, we have vaccinated pigs with a DNA vaccine encoding influenza virus hemagglutinin (HA) linked to the chemokine MIP1α that bind chemokine receptors 1, 3, and ...
DOI:
10.1016/j.vaccine.2019.11.084

18. High-fat diet triggers obesity-related early infiltration of macrophages into adipose tissue and transient reduction of blood monocyte count

Author:
Liu, Yanxia; Lu, Xinping; Li, Xialian; Du, Peijie; Qin, Guijun
Source:
Molecular immunology 2020 v.117 pp. 139-146
ISSN:
0161-5890
Subject:
chemokine CCL2; chemokine CCL7,   etc   ; adipose tissue; flow cytometry; fluorescent antibody technique; high fat diet; interleukin-1beta; lipid content; macrophages; males; monocytes; obesity; quantitative polymerase chain reaction;     Show all 13 Subjects
Abstract:
... Infiltration of adipose tissue macrophages (ATMs) is a typical feature of obesity, and circulating immune cells may indicate immune cell accumulation. However, it remains unclear whether this is true in the early stages of obesity. This study aimed to define the role of blood monocytes in obesity and the relationship between blood monocytes and ATMs in early-stage obesity. Two groups of male C57BL ...
DOI:
10.1016/j.molimm.2019.11.002

19. Quercetin alleviates rheumatoid arthritis by inhibiting neutrophil inflammatory activities

Author:
Yuan, Kai; Zhu, Qingqing; Lu, Qingyi; Jiang, Haixu; Zhu, Mengmeng; Li, Xiaohong; Huang, Guangrui; Xu, Anlong
Source:
The Journal of nutritional biochemistry 2020 v.84 pp. 108454
ISSN:
0955-2863
Subject:
chemokines,   etc   ; apoptosis; autophagy; blood plasma; cartilage; fruits; inflammation; mice; neutrophils; pathogenesis; quercetin; rheumatoid arthritis; therapeutics; vegetables;     Show all 14 Subjects
Abstract:
... Rheumatoid arthritis (RA) is a prototypical autoimmune disorder mainly characterized by joint inflammation and cartilage destruction. Neutrophils actively take part in the initiation and progression of RA. Neutrophils express inflammatory mediators, including cytokines and chemokines. Aberrant formation of neutrophil extracellular traps (NETs) has been demonstrated in the pathogenesis of RA. Thus, ...
DOI:
10.1016/j.jnutbio.2020.108454

20. Transcriptome analysis reveals molecular strategies in gills and heart of large yellow croaker (Larimichthys crocea) under hypoxia stress

Author:
Mu, Yinnan; Li, Wanru; Wei, Zuyun; He, Lianghua; Zhang, Weini; Chen, Xinhua
Source:
Fish & shellfish immunology 2020 v.104 pp. 304-313
ISSN:
1050-4648
Subject:
chemokine CCL17; chemokine CCL19; chemokine CCL25,   etc   ; CCR9 receptor; CXCR1 receptor; CXCR3 receptor; Larimichthys crocea; blood circulation; carboxylic acids; chemokine CCL3; complement; energy balance; energy conservation; fish; gas exchange; gene expression; gene expression regulation; gene ontology; genes; gills; glycolysis; heart; hypoxia; nitric oxide synthase; quantitative polymerase chain reaction; sequence analysis; tissues; transcriptomics; transporters; tricarboxylic acid cycle;     Show all 30 Subjects
Abstract:
... The gills and heart are two major targets of hypoxia in fish. However, the molecular responses in fish gills and heart to hypoxia challenge remain unclear. Here, RNA-Seq technology was used to study the gene expression profiles in gills and heart of large yellow croaker (Larimichthys crocea) at 6, 24, and 48 h after hypoxia stress. A total of 1,546 and 2,746 differentially expressed genes (DEGs) w ...
DOI:
10.1016/j.fsi.2020.06.028