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1. Identification of biomarkers associated with diagnosis and prognosis of colorectal cancer patients based on integrated bioinformatics analysis

Author:
Chen, Linbo; Lu, Dewen; Sun, Keke; Xu, Yuemei; Hu, Pingping; Li, Xianpeng; Xu, Feng
Source:
Gene 2019 v.692 pp. 119-125
ISSN:
0378-1119
Subject:
chemokine CCL19; chemokine CCL28; chemokine CXCL1,   etc   ; bioinformatics; biomarkers; chemokine CXCL11; chemokine CXCL12; chemokine CXCL5; colorectal neoplasms; computer software; data collection; databases; gene expression; genes; patients; prediction; prognosis; protein-protein interactions; screening; sequence analysis;     Show all 20 Subjects
Abstract:
... The current study aimed to identify potential diagnostic and prognostic gene biomarkers for colorectal cancer (CRC) based on the Gene Expression Omnibus (GEO) datasets and The Cancer Genome Atlas (TCGA) dataset.Microarray data of gene expression profiles of CRC from GEO and RNA-sequencing dataset of CRC from TCGA were downloaded. After screening overlapping differentially expressed genes (DEGs) by ...
DOI:
10.1016/j.gene.2019.01.001

2. High CXCL10/IP-10 levels are a hallmark in the clinical evolution of the HIV infection

Author:
Valverde-Villegas, Jacqueline María; de Medeiros, Rúbia Marília; Ellwanger, Joel Henrique; Santos, Breno Riegel; Melo, Marineide Gonçalves de; Almeida, Sabrina Esteves de Matos; Chies, José Artur Bogo
Source:
Infection, genetics, and evolution 2018 v.57 pp. 51-58
ISSN:
1567-1348
Subject:
chemokine CCL17; chemokine CCL2; chemokine CCL20,   etc   ; HIV infections; HIV long-term survivors; Human immunodeficiency virus; chemokine CCL22; chemokine CCL24; chemokine CXCL10; disease course; phenotype;     Show all 11 Subjects
Abstract:
... The aim of this study was to investigate the modulation of plasma CXCL10, CCL20, CCL22, CCL2, CCL17 and CCL24 levels in HIV-positive patients grouped according to extreme phenotypes of progression to AIDS, and at different stages of HIV infection. HIV-positive individuals with extreme phenotypes of AIDS progression (n=58) at different clinical stages (chronic individuals, both pre-HAART and under- ...
DOI:
10.1016/j.meegid.2017.11.002

3. An inter-switch between hydrophobic and charged amino acids generated druggable small molecule binding pocket in chemokine paralog CXCL3

Author:
Gulati, Khushboo; Gangele, Krishnakant; Kumar, Dinesh; Poluri, Krishna Mohan
Source:
Archives of biochemistry and biophysics 2019 v.662 pp. 121-128
ISSN:
0003-9861
Subject:
chemokine CXCL1; chemokine CXCL2; chemokine CXCL3,   etc   ; amino acids; fluorescence; gene duplication; hydrophobicity; multigene family; mutation; naphthalene; neoplasms; nuclear magnetic resonance spectroscopy; proteins; stoichiometry;     Show all 14 Subjects
Abstract:
... Multigene families such as chemokines arose as a result of gene duplication events, followed by mutations and selection. GRO chemokines are three duplicated CXCL genes, comprising of CXCL1, CXCL2 and CXCL3 proteins. Comparative structural analysis of the two closely related paralog chemokines CXCL2 and CXCL3 in the current study indicated a variable electrostatic surface between them, and a specif ...
DOI:
10.1016/j.abb.2018.12.007

4. Microfluidic assembly of hydrogel-based immunogenic tumor spheroids for evaluation of anticancer therapies and biomarker release

Author:
Sabhachandani, Pooja; Sarkar, Saheli; Mckenney, Seamus; Ravi, Dashnamoorthy; Evens, Andrew M.; Konry, Tania
Source:
Journal of controlled release 2019 v.295 pp. 21-30
ISSN:
0168-3659
Subject:
chemokine CCL2; chemokine CCL3; chemokine CCL4,   etc   ; B-cell lymphoma; B-lymphocytes; alginates; antineoplastic agents; biomarkers; cell adhesion; droplets; fibroblasts; hydrogels; models; monitoring; screening; therapeutics;     Show all 16 Subjects
Abstract:
... Diffuse large B cell lymphoma (DLBCL), the most common subtype of Non-Hodgkin lymphoma, exhibits pathologic heterogeneity and a dynamic immunogenic tumor microenvironment (TME). However, the lack of preclinical in vitro models of DLBCL TME hinders optimal therapeutic screening. This study describes the development of an integrated droplet microfluidics-based platform for high-throughput generation ...
DOI:
10.1016/j.jconrel.2018.12.010

5. Identification of potential embryokines in the bovine reproductive tract

Author:
Tríbulo, P.; Siqueira, L.G.B.; Oliveira, L.J.; Scheffler, T.; Hansen, P.J.
Source:
Journal of dairy science 2018 v.101 no.1 pp. 690-704
ISSN:
0022-0302
Subject:
chemokine CCL14; chemokine CCL21; chemokine CCL26,   etc   ; cattle; chemokine CX3CL1; chemokine CXCL10; chemokine CXCL12; chemokine CXCL16; chemokine CXCL3; embryogenesis; endometrium; estradiol; estrus; gene expression; genes; growth factors; interleukin-15; interleukin-18; interleukin-6; interleukin-8; oviducts; progesterone;     Show all 22 Subjects
Abstract:
... Knowledge of the molecules used by the maternal reproductive tract to regulate development of the preimplantation embryo is largely incomplete. The goal of the present experiment was to identify candidates for this function. The approach was to assess expression patterns in the endometrium and oviduct of 93 genes encoding for hormones, growth factors, chemokines, cytokines, and WNT-related molecul ...
DOI:
10.3168/jds.2017-13221

6. Method to quantify cytokines and chemokines in mouse brain tissue using Bio-Plex multiplex immunoassays

Author:
Manglani, Monica; Rua, Rejane; Hendricksen, Amy; Braunschweig, Daniel; Gao, Qian; Tan, Woei; Houser, Brett; McGavern, Dorian B.; Oh, Kenneth
Source:
Methods 2019 v.158 pp. 22-26
ISSN:
1046-2023
Subject:
chemokines,   etc   ; blood serum; brain; chemical species; immunoassays; mice;     Show all 6 Subjects
Abstract:
... This protocol describes how to prepare mouse brain tissue for quantification of multiple inflammatory mediators using a multiplex bead-based immunoassay. It is important to have methods that allow quantification of multiple analytes from small amounts of tissue. Bio-Plex is a Luminex xMAP-based multiplex bead-based immunoassay technology that permits simultaneous analysis of up to 100 analytes fro ...
DOI:
10.1016/j.ymeth.2019.02.007

7. CXCL17 promotes cell metastasis and inhibits autophagy via the LKB1-AMPK pathway in hepatocellular carcinoma

Author:
Wang, Linpei; Li, Haitao; Zhen, Zuojun; Ma, Xiaoqiu; Yu, Waishi; Zeng, Huahuo; Li, Li
Source:
Gene 2019 v.690 pp. 129-136
ISSN:
0378-1119
Subject:
chemokines,   etc   ; autophagy; biosynthesis; enzymes; hepatoma; histology; liver; metastasis; phenotype;     Show all 9 Subjects
Abstract:
... As an innovative CXC chemokine, CXCL17 has a mysterious clinical significance and modulating influence on hepatocellular carcinoma (HCC). Our study examined the activity and mechanisms of CXCL17 on growth, autophagy, and metastasis of HCC. Upregulation of CXCL17 expression was observed in HCC, which is correlated with poorer histological stages and outcomes. Elevation of CXCL17 expression promoted ...
DOI:
10.1016/j.gene.2018.12.043

8. Central neuroimmune activity and depressive-like behavior in response to repeated maternal separation and injection of LPS

Author:
Hennessy, Michael B.; Deak, Terrence; Sensenbaugh, Joshua D.; Gallimore, Darci M.; Garybush, Alexis M.; Mondello, Jamie E.; Schiml, Patricia A.
Source:
Physiology & behavior 2019 v.199 pp. 366-374
ISSN:
0031-9384
Subject:
chemokines,   etc   ; animal models; cortisol; enzymes; guinea pigs; inflammation; lipopolysaccharides; prostaglandins;     Show all 8 Subjects
Abstract:
... Disruption of attachment relations in early life is linked to greater vulnerability to depressive illness at later ages. Evidence suggests this process involves stress-induced activation of central inflammatory factors, though the specific mediators and processes involved are not known. We used a guinea pig model in which effects of maternal separation appear more clearly due to absence of the att ...
DOI:
10.1016/j.physbeh.2018.11.040

9. A marine-sourced fucoidan solution inhibits Toll-like-receptor-3-induced cytokine release by human bronchial epithelial cells

Author:
Dutot, M.; Grassin-Delyle, S.; Salvator, H.; Brollo, M.; Rat, P.; Fagon, R.; Naline, E.; Devillier, P.
Source:
International journal of biological macromolecules 2019 v.130 pp. 429-436
ISSN:
0141-8130
Subject:
chemokine CCL2; chemokine CCL20; chemokine CCL22,   etc   ; Phaeophyceae; Toll-like receptor 3; agonists; chemokine CCL5; chemokine CXCL1; chemokine CXCL5; enzyme-linked immunosorbent assay; epithelial cells; epithelium; fucoidan; gene expression; humans; immunomodulators; inflammation; interleukin-1alpha; interleukin-1beta; interleukin-6; interleukin-8; messenger RNA; models; prostaglandin synthase; prostaglandins; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; tumor necrosis factor-alpha;     Show all 28 Subjects
Abstract:
... Fucoidans are sulfated polysaccharides from brown algae, known to have immunomodulatory activity. Their effects on the response of airway epithelial cells to Toll-like receptor 3 (TLR3) stimulation have not been characterized. Our objective was to evaluate the effects of a marine-sourced fucoidan solution (MFS) on the TLR3-induced expression and/or production of cytokines and prostaglandin by huma ...
DOI:
10.1016/j.ijbiomac.2019.02.113

10. CXCL13 polymorphism is associated with essential hypertension in Tatars from Russia

Author:
Timasheva, Yanina R.; Nasibullin, Timur R.; Tuktarova, Ilsiyar A.; Erdman, Vera V.; Mustafina, Olga E.
Source:
Molecular biology reports 2018 v.45 no.5 pp. 1557-1564
ISSN:
0301-4851
Subject:
chemokine CCL16; chemokine CCL17; chemokine CCL23,   etc   ; alleles; chemokine CCL8; chemokine CXCL13; genetic models; genotype; genotyping; hypertension; men; nationalities and ethnic groups; patients; Russia;     Show all 14 Subjects
Abstract:
... Essential arterial hypertension is a disease with distinct yet unexplored inflammatory component. Our aim was to assess the role of chemokine genes and their interaction in its development. Genotyping of polymorphic markers in six chemokine genes (CXCL13, CCL8, CCL16, CCL17, CCL18, and CCL23) was performed in the group of 522 men of Tatar ethnic origin from the Republic of Bashkortostan, Russia (2 ...
DOI:
10.1007/s11033-018-4257-x

11. Assessment of chemokine and cytokine signatures in patients with dengue infection: A hospital-based study in Kolkata, India

Author:
Patra, Goutam; Mallik, Sudeshna; Saha, Bibhuti; Mukhopadhyay, Sumi
Source:
Acta tropica 2019 v.190 pp. 73-79
ISSN:
0001-706X
Subject:
chemokine CCL5; chemokine CXCL10; chemokine CXCL9,   etc   ; albumins; arthropods; blood; blood platelet count; dengue; fever; gastrointestinal system; hematocrit; immunomodulators; interleukin-10; interleukin-12; interleukin-6; interleukin-8; liver function; patients; transforming growth factor beta; India; South East Asia;     Show all 21 Subjects
Abstract:
... Dengue fever is an acute viral infection transmitted by arthropods but may evolve to severe clinical manifestations. Descriptions of the role of circulating immune modulators such as cytokines or chemokines in dengue immunopathogenesis have largely relied on data from South-east Asia and America, while India is poorly represented. This study characterizes dengue cases from West Bengal, eastern Ind ...
DOI:
10.1016/j.actatropica.2018.10.017

12. Air pollution and inflammation: Findings from concurrent repeated measures of systemic and reproductive tract cytokines during term pregnancy in Mexico City

Author:
Buxton, Miatta A.; Meraz-Cruz, Noemi; Sanchez, Brisa N.; Gronlund, Carina J.; Foxman, Betsy; Vadillo-Ortega, Felipe; O'Neill, Marie S.
Source:
The Science of the total environment 2019 v.681 pp. 235-241
ISSN:
0048-9697
Subject:
chemokine CCL3; chemokine CCL4,   etc   ; air pollution; blood serum; carbon monoxide; environmental exposure; inflammation; interleukin-6; models; particulates; pregnancy outcome; tumor necrosis factor-alpha; women; Mexico;     Show all 14 Subjects
Abstract:
... Environmental exposures are associated with a number of outcomes including adverse pregnancy outcomes. Although inflammation is hypothesized to play a role, the mechanistic pathways between environmental exposures and adverse health outcomes, including associations between exposures and longitudinal measures of systemic and reproductive tract inflammation, need elucidation.This study was conducted ...
DOI:
10.1016/j.scitotenv.2019.05.041

13. Comparison in transcriptome and cytokine profiles of mesenchymal stem cells from human umbilical cord and cord blood

Author:
Meng, Xianhui; Sun, Bo; Xiao, Zhongdang
Source:
Gene 2019 v.696 pp. 10-20
ISSN:
0378-1119
Subject:
chemokine CCL2; chemokine CXCL1,   etc   ; antibodies; blood; cell adhesion; growth factors; humans; insulin secretion; interleukin-6; interleukin-8; mesenchymal stromal cells; signal transduction; therapeutics; transcriptome; transcriptomics; umbilical cord;     Show all 16 Subjects
Abstract:
... Human umbilical cord (UC) and cord blood (CB) provide attractive sources of mesenchymal stem cells (MSCs) for cell therapy. Both UCMSCs and CBMSCs have been demonstrated to play prominent roles in clinical therapy. However, little is known about their functional differences in clinical application. Our transcriptome analysis uncovered high activity of insulin secretion related signaling pathways f ...
DOI:
10.1016/j.gene.2019.02.017

14. Genes and transcription factors related to the adverse effects of maternal type I diabetes mellitus on fetal development

Author:
Han, Shuyi; Yang, Huili; Han, Yunhui; Zhang, Hongzhi
Source:
Molecular and cellular probes 2019 v.43 pp. 64-71
ISSN:
0890-8508
Subject:
chemokine CCL5; chemokine CXCL12,   etc   ; data collection; fetal development; gene expression; genes; microarray technology; mothers; neonates; pregnancy outcome; protein-protein interactions; risk; signal transduction; transcription factors; umbilical cord;     Show all 15 Subjects
Abstract:
... Maternal type I diabetes mellitus (T1DM) increases the risk of adverse pregnancy outcomes, but the corresponding mechanism is unclear. This study aims to investigate the mechanism underlying the adverse pregnancy outcomes of maternal T1DM.Gene expression microarray (GSE51546) was down-loaded from the Gene Expression Omnibus. This dataset included 12 umbilical cord samples from the newborns of T1DM ...
DOI:
10.1016/j.mcp.2018.11.003

15. Identification of bovine tuberculosis biomarkers to detect tuberculin skin test and IFNγ release assay false negative cattle

Author:
Klepp, L.I.; Eirin, M.E.; Garbaccio, S.; Soria, M.; Bigi, F.; Blanco, F.C.
Source:
Research in veterinary science 2019 v.122 pp. 7-14
ISSN:
0034-5288
Subject:
chemokine CXCL10; chemokine CXCL9,   etc   ; biomarkers; bovine tuberculosis; cattle; financial economics; interleukin-17; mononuclear leukocytes; necropsy; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; tuberculin; zoonoses;     Show all 13 Subjects
Abstract:
... Bovine tuberculosis (bTB) is an important animal and zoonotic disease, which causes severe economic losses. The main focus of this study was to assess the predictive power of previously identified biomarkers of bTB in infected animals that were negative to the tuberculin skin test (TST). We studied 16 animals with bTB, in which the disease was confirmed by necropsy, and 16 healthy animals. The lev ...
DOI:
10.1016/j.rvsc.2018.10.016

16. Hippo kinase NDR2 inhibits IL-17 signaling by promoting Smurf1-mediated MEKK2 ubiquitination and degradation

Author:
Ma, Xianwei; Wang, Dan; Li, Na; Gao, Peng; Zhang, Mei; Zhang, Yan
Source:
Molecular immunology 2019 v.105 pp. 131-136
ISSN:
0161-5890
Subject:
chemokine CCL20; chemokine CXCL2,   etc   ; inflammation; interleukin-17; interleukin-6; mitogen-activated protein kinase; transcription factor NF-kappa B; ubiquitin-protein ligase; ubiquitination; yeasts;     Show all 10 Subjects
Abstract:
... NDR/LATS kinase family are conserved from yeast to man and their roles in inflammation remains largely unknown. In the present study, we show that knockdown of NDR2 significantly increases IL-17-induced IL-6, CXCL2 and CCL20 expression in Hela and HT-29 cells. Knockdown of NDR2 enhances IL-17-induced MAPK and NF-κB activation. NDR2 interacts with E3 ubiquitin protein ligase Smurf1, promotes Smurf1 ...
DOI:
10.1016/j.molimm.2018.10.005

17. A guide to chemokines and their receptors

Author:
Hughes, Catherine E.; Nibbs, Robert J. B.
Source:
TheFEBS journal 2018 v.285 no.16 pp. 2944-2971
ISSN:
1742-464X
Subject:
chemokine receptors; chemokines,   etc   ; cell movement; chemotaxis; extracellular matrix; homeostasis; inflammation; leukocytes; post-translational modification;     Show all 9 Subjects
Abstract:
... The chemokines (or chemotactic cytokines) are a large family of small, secreted proteins that signal through cell surface G protein‐coupled heptahelical chemokine receptors. They are best known for their ability to stimulate the migration of cells, most notably white blood cells (leukocytes). Consequently, chemokines play a central role in the development and homeostasis of the immune system, and ...
DOI:
10.1111/febs.14466

18. Sevoflurane-medicated the pathway of chemokine receptors bind chemokines in patients undergoing CABG

Author:
Kong, Bing; Ma, Yu-Wu; Li, De-Xue; Liu, Xi-Jiang; Xu, Yong-Guang
Source:
Open life sciences 2017 v.12 no.1 pp. 443-451
ISSN:
2391-5412
Subject:
chemokine receptors; chemokines,   etc   ; cardioprotective effect; coronary vessels; genes; patients; surgery;     Show all 7 Subjects
Abstract:
... We aim to identify sevoflurane-induced modules and pathways in patients following coronary artery bypass graft (CABG) surgery, and to further elucidate the molecular mechanisms of the cardioprotective effects of sevoflurane. Differential co-expression network (DCN) was constructed. Candidate modules were identified via three steps: selection of seed genes, search of modules using snowball sampling ...
DOI:
10.1515/biol-2017-0052

19. Analysis of FAM19A2/TAFA-2 function

Author:
Okada, Junichi; Yamada, Eijiro; Saito, Tsugumichi; Ozawa, Atsushi; Nakajima, Yasuyo; Pessin, Jeffrey E.; Okada, Shuichi; Yamada, Masanobu
Source:
Physiology & behavior 2019 v.208 pp. 112581
ISSN:
0031-9384
Subject:
chemokine CCL3,   etc   ; biochemical pathways; body temperature; energy expenditure; mice; portion size; scotophase; sequence analysis;     Show all 8 Subjects
Abstract:
... FAM19A2/TAFA-2, a member of the chemokine CC family, shares 31% sequence identity with MIP-1α, which is known to elevate body temperature and reduce food intake. A single administration of 250 pM of FAM19A2/TAFA-2 to the third ventricle of mice just before the initiation of dark period increased food intake and meal number significantly, but reduced meal size during the dark period. The respirator ...
DOI:
10.1016/j.physbeh.2019.112581

20. Molecular dynamics based improvement of the solubilizing self-cleavable tag Zbasic-ΔI-CM application in the preparation of recombinant proteins in Escherichia coli

Author:
Luo, Han; Hu, Lifu; Ma, Buyong; Zhao, Meiqi; Luo, Manyu; Deng, Qing; Deng, Shaorong; Ye, Hao; Lin, Tong; Chen, Junsheng; Wang, Tao; Zhu, Jianwei; Lu, Huili
Source:
Biochemical and biophysical research communications 2019 v.513 no.2 pp. 412-418
ISSN:
0006-291X
Subject:
chemokine CXCL9,   etc   ; Escherichia coli; biopharmaceuticals; inclusion bodies; molecular dynamics; recombinant proteins; simulation models; solubilization;     Show all 8 Subjects
Abstract:
... Zbasic-ΔI-CM is a novel intein-based self-cleavable tag we developed to accelerate the soluble expression of recombinant proteins in Escherichia coli (E. coli). Previously we found that intein activity could be interfered by its flanking exteins, and thus reducing the production efficiency and final yield. In this work, we used CXC-chemokine 9 (CXCL9) as a model C-extein, which fusion with Zbasic- ...
DOI:
10.1016/j.bbrc.2019.03.205