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You searched for: Subject "chemosensitization" Remove constraint Subject: "chemosensitization"
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1. Nanoprodrug ratiometrically integrating autophagy inhibitor and genotoxic agent for treatment of triple-negative breast cancer

Author:
Huifang Wang; Haoyu Bai; Jiafeng Wang; Xuefei Zhou; Hongda Chen; Liying Wang; Huiming Ren; Zimo Liu; Wei Zhuo; Zhuxian Zhou; Jianbin Tang; Zhijie Li; Jigang Wang; Youqing Shen; Tianhua Zhou; Xiangrui Liu
Source:
Biomaterials 2022 v.283 pp. 121458
ISSN:
0142-9612
Subject:
chemosensitization,   etc   ; DNA damage; apoptosis; autophagy; biocompatible materials; blood circulation; breast neoplasms; cytotoxicity; drugs; metastasis; mice; mutagens; pharmacokinetics; polymers;     Show all 14 Subjects
Abstract:
... Effective combination therapies are urgently needed to treat triple-negative breast cancer (TNBC), which is insensitive to the existing treatment regimens. However, the synergistic potency of traditional small-molecule combinations is limited in TNBC mainly due to mismatched molar ratios, inconsistent pharmacokinetics, and intratumoral accumulation of individual drugs. Here, we find that the autop ...
DOI:
10.1016/j.biomaterials.2022.121458

2. Promising anticancer activities and mechanisms of action of active compounds from the medicinal herb Centipeda minima (L.) A. Braun & Asch

Author:
Yong-Qiang Liu; Guang-Biao Zhou
Source:
Phytomedicine 2022 v.106 pp. 154397
ISSN:
0944-7113
Subject:
chemosensitization,   etc   ; Oriental traditional medicine; alopecia; chlorogenic acid; glioma; headache; hypersensitivity; medicinal plants; phytochemicals; rhinitis; sesquiterpenoid lactones; sinusitis; ubiquitin-protein ligase; China;     Show all 14 Subjects
Abstract:
... Centipeda minima (L.) A. Braun & Asch (C. minima) has been used as a traditional Chinese herbal medicine to treat multiple diseases, including sinusitis, rhinitis, headache, and allergy. To date, the anticancer properties of C. minima have drawn considerable attention owing to the anticancer potential of C. minima extracts, the identification of active components, and the elucidation of underlying ...
DOI:
10.1016/j.phymed.2022.154397

3. Sesamol Augments Paclitaxel-Induced Apoptosis in Human Cervical Cancer Cell Lines

Author:
Jiayi Xiong; Juanjuan Sheng; Yan Wei; Zhimin Sun; Xia Xiao; Lanmei Zhang
Source:
Nutrition and cancer 2022 v.74 no.10 pp. 3692-3700
ISSN:
1532-7914
Subject:
chemosensitization,   etc   ; DNA damage; apoptosis; drug therapy; human cell lines; humans; membrane potential; mitochondrial membrane; neoplasm cells; nutrition; paclitaxel; uterine cervical neoplasms;     Show all 12 Subjects
Abstract:
... Natural medicinal compounds have gained increasing attention as adjuvants during cancer chemotherapy. The present study demonstrated the chemosensitizing effect of sesamol, a natural phenolic compound, in HeLa cell lines In Vitro. Sesamol-pretreated (10 μM) HeLa cells were exposed to 7.5 nM paclitaxel. The chemosensitization was estimated by MTT-based metabolic assay. Further, oxidative DNA damage ...
DOI:
10.1080/01635581.2022.2079684

4. Triterpenes from Pholiota populnea as Cytotoxic Agents and Chemosensitizers to Overcome Multidrug Resistance of Cancer Cells

Author:
Morteza Yazdani; Zoltán Béni; Miklós Dékány; Nikoletta Szemerédi; Gabriella Spengler; Judit Hohmann; Attila Ványolós
Source:
Journal of natural products 2022 v.85 no.4 pp. 910-916
ISSN:
1520-6025
Subject:
chemosensitization,   etc   ; P-glycoproteins; Pholiota; adenocarcinoma; chromatography; colon; cytotoxicity; doxorubicin; ergosterol; esters; growth retardation; hexane; metabolites; multiple drug resistance; neoplasm cells; polyols; triterpenoids;     Show all 17 Subjects
Abstract:
... The detailed mycochemical analysis of the n-hexane extract of Pholiota populnea led to the isolation of four new lanostane diesters, named pholiols A–D (1–4), together with an acyclic triterpene, (3S,6E,10E,14E,18E,22S)-2,3,22,23-tetrahydroxy-2,6,10,15,19,23-hexamethyl-6,10,14,18-tetracosatetraene (5), ergosterol (6), and 3β-hydroxyergosta-7,22-diene (7). The isolation was carried out by multistep ...
DOI:
10.1021/acs.jnatprod.1c01024

5. Lovastatin enhances chemosensitivity of paclitaxel-resistant prostate cancer cells through inhibition of CYP2C8

Author:
Ying Li; Sisi Chen; Jianyu Zhu; Chanjuan Zheng; Muyao Wu; Lian Xue; Guangchun He; Shujun Fu; Xiyun Deng
Source:
Biochemical and biophysical research communications 2022 v.589 pp. 85-91
ISSN:
0006-291X
Subject:
chemosensitization,   etc   ; apoptosis; bioinformatics; cell lines; cell viability; databases; drug resistance; drug therapy; hyperlipidemia; lovastatin; models; neoplasm cells; paclitaxel; prostatic neoplasms; research; viability assays;     Show all 16 Subjects
Abstract:
... Chemotherapy is the mainstay of treatment for prostate cancer, with paclitaxel being commonly used for hormone-resistant prostate cancer. However, drug resistance often develops and leads to treatment failure in a variety of prostate cancer patients. Therefore, it is necessary to enhance the sensitivity of prostate cancer to chemotherapy. Lovastatin (LV) is a natural compound extracted from Monasc ...
DOI:
10.1016/j.bbrc.2021.12.007

6. Manuka honey in combination with 5-Fluorouracil decreases physical parameters of colonspheres enriched with cancer stem-like cells and reduces their resistance to apoptosis

Author:
Danila Cianciosi; Tamara Y. Forbes-Hernández; Lucia Regolo; José M. Alvarez-Suarez; Denise Quinzi; Azzurra Sargenti; Weibin Bai; Lingmin Tian; Francesca Giampieri; Maurizio Battino
Source:
Food chemistry 2022 v.374 pp. 131753
ISSN:
0308-8146
Subject:
chemosensitization,   etc   ; apoptosis; cell lines; colon; colorectal neoplasms; fluorouracil; food chemistry; insulin-like growth factor I receptor; manuka honey; mass density; neoplasm cells; pro-apoptotic proteins;     Show all 12 Subjects
Abstract:
... The aim of the present work was to evaluate the in vitro effect of Manuka honey and its combination with 5-Fu, the most common drug used in the treatment of colon cancer, on the morphological and physical parameters of colonspheres enriched with cancer stem-like cells deriving from HCT-116 colon adenocarcinoma cell line and on the apoptosis rate. Manuka honey, alone and more in combination with 5- ...
DOI:
10.1016/j.foodchem.2021.131753

7. Modulation of diverse oncogenic signaling pathways by oroxylin A: An important strategy for both cancer prevention and treatment

Author:
Anjana Sajeev; Mangala Hegde; Uzini Devi Daimary; Aviral Kumar; Sosmitha Girisa; Gautam Sethi; Ajaikumar B. Kunnumakkara
Source:
Phytomedicine 2022 v.105 pp. 154369
ISSN:
0944-7113
Subject:
chemosensitization,   etc   ; Oroxylum indicum; Scutellaria baicalensis; antineoplastic agents; brain; breasts; cancer recurrence; colon; flavonoids; gall bladder; liver; lungs; mechanism of action; meta-analysis; pharmacodynamics; pharmacokinetics; radiation resistance; systematic review; toxicity;     Show all 19 Subjects
Abstract:
... Regardless of major advances in diagnosis, prevention and treatment strategies, cancer is still a foreboding cause due to factors like chemoresistance, radioresistance, adverse side effects and cancer recurrence. Therefore, continuous development of unconventional approaches is a prerequisite to overcome foregoing glitches. Natural products have found their way into treatment of serious health con ...
DOI:
10.1016/j.phymed.2022.154369

8. Berberine—A potent chemosensitizer and chemoprotector to conventional cancer therapies

Author:
Nalini Devarajan; Selvaraj Jayaraman; Jaideep Mahendra; Purushothaman Venkatratnam; Ponnulakshmi Rajagopal; Hema Palaniappan; Senthil Kumar Ganesan
Source:
Phytotherapy research 2021 v.35 no.6 pp. 3059-3077
ISSN:
0951-418X
Subject:
chemosensitization,   etc   ; berberine; cancer therapy; cytotoxicity; drug therapy; drugs; heart; liver; phytotherapy; radiation resistance; radiotherapy; research;     Show all 12 Subjects
Abstract:
... Chemotherapy and radiotherapy are mainstay treatments for cancer patients. However, their clinical outcomes are highly limited by the resistance of malignant tumors to these therapies and the incurrence of serious damages in vital organs. This in turn necessitates the development of adjunct drugs that overcomes chemo/radioresistance in refractory cancers and protects vital organs from the cytotoxi ...
DOI:
10.1002/ptr.7032

9. Bioactivity inspired C19-diterpenoid alkaloids for overcoming multidrug-resistant cancer

Author:
Koji Wada; Masuo Goto; Emika Ohkoshi; Kuo-Hsiung Lee; Hiroshi Yamashita
Source:
Natural medicines 2022 v.76 no.4 pp. 796-802
ISSN:
1340-3443
Subject:
chemosensitization,   etc   ; P-glycoproteins; cell lines; cytotoxicity; doxorubicin; multiple drug resistance; neoplasm cells; paclitaxel; verapamil; vincristine;     Show all 10 Subjects
Abstract:
... The pharmacological activities of C₁₉-diterpenoid alkaloids are related to their basic skeletons (e.g., aconitine-type or lycoctonine-type). Also, few studies have been reported on the chemosensitizing effects of diterpenoid alkaloids. Consequently, this study was aimed at determining the chemosensitizing effects of synthetic derivatives of lycoctonine-type C₁₉-diterpenoid alkaloids on a P-glycopr ...
DOI:
10.1007/s11418-022-01629-y

10. Chemosensitizing effect of neferine on cisplatin-resistant colorectal cancer: Identification of potential candidate genes and pathways through whole transcriptome profiling

Author:
Bharath Somasundram; Prasath Manogaran; Madavan Vasudevan; Vijaya Padma Viswanadha
Source:
Phytomedicine plus 2022 v.2 no.3 pp. 100299
ISSN:
2667-0313
Subject:
chemosensitization,   etc   ; DNA damage; DNA repair; DNA replication; Nelumbo nucifera; Western blotting; alkaloids; bioinformatics; cell cycle; cell lines; cisplatin; colorectal neoplasms; data quality; drug resistance; drug therapy; gene expression regulation; genes; propidium; proteasome endopeptidase complex; quality control; quantitative polymerase chain reaction; toxicity testing; transcriptome; transcriptomics;     Show all 24 Subjects
Abstract:
... Cisplatin drug resistance is a serious impediment for the therapeutic success against platinum-based chemotherapy in several cancers. Neferine, a bisbenzylisoquinoline alkaloid from Nelumbo nucifera is an effective anticancer agent which has shown potential to reverse the chemo-resistance in cisplatin-resistant colorectal cancer (CRC) cells. The purpose of the study to explore the mechanism of che ...
DOI:
10.1016/j.phyplu.2022.100299

11. Chemosensitization of Temozolomide-Resistant Pediatric Diffuse Midline Glioma Using Potent Nanoencapsulated Forms of a N(3)-Propargyl Analogue

Author:
Vahid Heravi Shargh; Jeni Luckett; Kaouthar Bouzinab; Stephen Paisey; Lyudmila Turyanska; William G. B. Singleton; Stephen Lowis; Pavel Gershkovich; Tracey D. Bradshaw; Malcolm F. G. Stevens; Alison Bienemann; Beth Coyle
Source:
ACS applied materials & interfaces 2021 v.13 no.30 pp. 35266-35280
ISSN:
1944-8252
Subject:
chemosensitization,   etc   ; alkylation agents; blood-brain barrier; convection; drugs; ferritin; glioma; hydrodynamics; nanocapsules; parenchyma (animal tissue); pharmacokinetics; solubility; toxicity;     Show all 13 Subjects
Abstract:
... The lack of clinical response to the alkylating agent temozolomide (TMZ) in pediatric diffuse midline/intrinsic pontine glioma (DIPG) has been associated with O⁶-methylguanine-DNA-methyltransferase (MGMT) expression and mismatch repair deficiency. Hence, a potent N(3)-propargyl analogue (N3P) was derived, which not only evades MGMT but also remains effective in mismatch repair deficient cells. Due ...
DOI:
10.1021/acsami.1c04164

12. Incorporation of natural assumption to deal with cancer

Author:
Chenmala Karthika; Raman Sureshkumar
Source:
Environmental science and pollution research 2021 v.28 no.5 pp. 4902-4917
ISSN:
0944-1344
Subject:
chemosensitization,   etc   ; antioxidants; cancer therapy; drug therapy; fearfulness; flavonoids; food additives; health services; humans; medicine; metabolites; pain; patients; pollution; research;     Show all 15 Subjects
Abstract:
... The current state of the art for the use of natural ingredients for cancer therapy is by reviewing the publications and findings associated with cancer research with the employment of flavonoids. Cancer is the most furious disease making fear in the eyes of mankind. Though various treatment methods are prevalent, the patient’s choices are shifting from synthetic treatment strategy to the natural o ...
DOI:
10.1007/s11356-020-11479-4

13. Pilose antler polypeptides promote chemosensitization and T-cell infiltration of triple-negative breast cancer

Author:
Mohan Li; Kexin Zheng; Shiliang Ma; Pengpeng Hu; Bo Yuan; Xiqing Yue; Qilong Li
Source:
Journal of functional foods 2021 v.85 pp. 104664
ISSN:
1756-4646
Subject:
chemosensitization,   etc   ; actin; adjuvants; breast neoplasms; drug therapy; flow cytometry; functional foods; immunohistochemistry; immunosuppression; mice; neoplasm progression; polypeptides; vimentin; water solubility; weight loss;     Show all 15 Subjects
Abstract:
... In this study, we aimed to determine the effects of combined neoadjuvant chemotherapy (NAC) and water-soluble polypeptides from pilose antler (PAWP) administration on mouse TNBC 4T1 tumors using multiplex immunohistochemistry and flow cytometry to enhance chemosensitization and alleviate immunosuppression. Our findings reveal that PAWPs significantly reduce tumor growth and decrease weight loss in ...
DOI:
10.1016/j.jff.2021.104664

14. Salidroside Promotes Sensitization to Doxorubicin in Human Cancer Cells by Affecting the PI3K/Akt/HIF Signal Pathway and Inhibiting the Expression of Tumor-Resistance-Related Proteins

Author:
Qi Zeng; Xu Nie; Li Li; Hui-Fang Liu; Yang-Yao Peng; Wang-Ting Zhou; Xiao-Jia Hu; Xin-Yi Xu; Xue-Li Chen
Source:
Journal of natural products 2022 v.85 no.1 pp. 196-204
ISSN:
1520-6025
Subject:
chemosensitization,   etc   ; Rhodiola rosea; bioluminescence; cell proliferation; doxorubicin; drug therapy; humans; models; multiple drug resistance; neoplasm cells; neoplasm progression; neoplasms; phosphatidylinositol 3-kinase; salidroside; signal transduction; xenotransplantation;     Show all 16 Subjects
Abstract:
... Salidroside (Sal), the major active constituent of Rhodiola rosea L., is considered as a potential pro-drug with various activities; however, its role in tumor therapy is not clear. Here, we demonstrated in vitro and in vivo that Sal enhanced the inhibitory activity of doxorubicin (DOX) in drug-resistant cancer cell lines. Our results showed that combination drug treatment (Sal and DOX) significan ...
DOI:
10.1021/acs.jnatprod.1c00950

15. Synthesis of new piperazinyl-pyrrolo[1,2-a]quinoxaline derivatives as inhibitors of Candida albicans multidrug transporters by a Buchwald–Hartwig cross-coupling reaction

Author:
Jean Guillon; Shweta Nim; Stéphane Moreau; Luisa Ronga; Solène Savrimoutou; Elisabeth Thivet; Mathieu Marchivie; Attilio Di Pietro; Rajendra Prasad; Marc Le Borgne
Source:
RSC advances 2020 v.10 no.5 pp. 2915-2931
ISSN:
2046-2069
Subject:
chemosensitization,   etc   ; Candida albicans; Saccharomyces cerevisiae; antifungal properties; cross-coupling reactions; fluconazole; synergism; yeasts;     Show all 8 Subjects
Abstract:
... Two series of piperazinyl-pyrrolo[1,2-a]quinoxaline derivatives were prepared via a Buchwald–Hartwig cross-coupling reaction and then evaluated for their ability to inhibit the drug efflux activity of CaCdr1p and CaMdr1p transporters of Candida albicans overexpressed in a Saccharomyces cerevisiae strain. In the initial screening of twenty-nine piperazinyl-pyrrolo[1,2-a]quinoxaline derivatives, twe ...
DOI:
10.1039/c9ra09348f

16. APE1 and SSRP1 is overexpressed in muscle invasive bladder cancer and associated with poor survival

Author:
Heyu Song; Jiping Zeng; Subodh Lele; Chad A. LaGrange; Kishor K. Bhakat
Source:
Heliyon 2021 v.7 no.4 pp. e06756
ISSN:
2405-8440
Subject:
chemosensitization,   etc   ; DNA repair; carcinoma; chromatin; drug resistance; histones; humans; immunohistochemistry; muscles; nucleobases; urinary bladder neoplasms;     Show all 11 Subjects
Abstract:
... Human apurinic/apyrimidinic (AP) endonuclease 1 (APE1) plays a critical role in DNA base excision repair (BER) pathway and has been reported to be overexpressed in multiple cancers. Previously, we have shown that histone chaperone FACT complex (Facilitates Chromatin Transcription, a heterodimer of SSRP1 and SPT16 proteins) facilitates the chromatin access and DNA repair function of APE1, and their ...
DOI:
10.1016/j.heliyon.2021.e06756

17. The role of curcumin/curcuminoids during gastric cancer chemotherapy: A systematic review of non-clinical study

Author:
Masoud Najafi; Keywan Mortezaee; Mahban Rahimifard; Bagher Farhood; Hamed Haghi-Aminjan
Source:
Life sciences 2020 v.257 pp. 118051
ISSN:
0024-3205
Subject:
chemosensitization,   etc   ; apoptosis; cell viability; curcumin; cytotoxicity; drug therapy; metastasis; oxidative stress; stomach neoplasms; systematic review;     Show all 10 Subjects
Abstract:
... Chemotherapy is an effective therapeutic modality which is commonly used for battling various cancers. However, several side effects induced by chemotherapeutic drugs would limit their clinical use. The present systematic review aims to evaluate the role of curcumin/curcuminoids co-administration during gastric cancer chemotherapy. This systematic review was done according to PRISMA guidelines and ...
DOI:
10.1016/j.lfs.2020.118051

18. Hesperidin and its aglycone hesperetin in breast cancer therapy: A review of recent developments and future prospects

Author:
Kah Min Yap; Mahendran Sekar; Yuan Seng Wu; Siew Hua Gan; Nur Najihah Izzati Mat Rani; Lay Jing Seow; Vetriselvan Subramaniyan; Neeraj Kumar Fuloria; Shivkanya Fuloria; Pei Teng Lum
Source:
Saudi journal of biological sciences 2021 v.28 no.12 pp. 6730-6747
ISSN:
1319-562X
Subject:
chemosensitization,   etc   ; Citrus; DNA repair; apoptosis; bioavailability; breast neoplasms; cancer therapy; cell cycle checkpoints; cell proliferation; doxorubicin; drug resistance; drug therapy; glucose; hesperetin; hesperidin; lipids; liver; metabolism; metastasis; microRNA; mortality; tamoxifen; water solubility;     Show all 23 Subjects
Abstract:
... Breast cancer (BC) has high incidence and mortality rates, making it a major global health issue. BC treatment has been challenging due to the presence of drug resistance and the limited availability of therapeutic options for triple-negative and metastatic BC, thereby urging the exploration of more effective anti-cancer agents. Hesperidin and its aglycone hesperetin, two flavonoids from citrus sp ...
DOI:
10.1016/j.sjbs.2021.07.046

19. Essential Oils, Pituranthos chloranthus and Teucrium ramosissimum, Chemosensitize Resistant Human Uterine Sarcoma MES-SA/Dx5 Cells to Doxorubicin by Inducing Apoptosis and Targeting P-Glycoprotein

Author:
Aida Lahmar; Aline Mathey; Virginie Aires; Dorra Elgueder; Anne Vejux; Rihab Khlifi; Fairouz Sioud; Leila Chekir-Ghedira; Dominique Delmas
Source:
Nutrients 2021 v.13 no.5 pp. -
ISSN:
2072-6643
Subject:
chemosensitization,   etc   ; Chloranthus; Deverra; P-glycoproteins; Teucrium; adenosinetriphosphatase; apoptosis; caspases; cell cycle; cell viability; chemoprevention; doxorubicin; drug therapy; humans; mitochondrial membrane; mortality; multiple drug resistance; neoplasm cells; phenotype; reactive oxygen species; sarcoma; synergism;     Show all 22 Subjects
Abstract:
... The multidrug resistance phenotype is a global phenomenon and causes chemotherapy failure in various cancers, such as in uterine sarcomas that have a high mortality rate. To overcome this phenotype, there is growing research interest in developing new treatment strategies. In this study, we highlight the potential of two essential oils from the Apiaceae family, Pituranthos chloranthus (PC) and Teu ...
DOI:
10.3390/nu13051719

20. Effect of plant-based compounds on the antifungal and antiaflatoxigenic efficiency of strobilurins against Aspergillus flavus

Author:
Fei Tian; Sang Yoo Lee; So Young Woo; Hwa Young Choi; Su Been Park; Hyang Sook Chun
Source:
Journal of hazardous materials 2021 v.415 pp. 125663
ISSN:
0304-3894
Subject:
chemosensitization,   etc   ; Aspergillus flavus; aflatoxins; azoxystrobin; carcinogenicity; food security; fungi; human health; mutagens; pyraclostrobin; secondary metabolites;     Show all 11 Subjects
Abstract:
... Aflatoxins are a group of carcinogenic and mutagenic fungal secondary metabolites that have threatened human health and global food security. Aflatoxin contamination can be controlled by applying fungicides, such as strobilurins. Although these compounds have been effective, they may be risky to the environment due to their wide usage. In this study, plant-based compounds were tested to promote th ...
DOI:
10.1016/j.jhazmat.2021.125663