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1. Ultrasmall enzyme/light-powered nanomotor facilitates cholesterol detection

Author:
Yang Hu; Zixuan Li; Yan Sun
Source:
Journal of colloid and interface science 2022 v.621 pp. 341-351
ISSN:
0021-9797
Subject:
cholesterol; cholesterol oxidase,   etc   ; biocatalysis; energy; forces; irradiation; oxidation;     Show all 7 Subjects
Abstract:
... Enzymes that can convert chemical energy into mechanical force through biocatalysis have been used as engines for artificial micro/nanomotors. However, most nanomotors are powered by only one engine and have a microscale size range, which greatly limits their application scenarios. Herein, an ultrasmall enzyme/light-powered nanomotor (71.1 ± 8.2 nm) is prepared by directly coupling ultrasmall hist ...
DOI:
10.1016/j.jcis.2022.04.086

2. Pseudorabies Virus Inhibits Expression of Liver X Receptors to Assist Viral Infection

Author:
Yi Wang; Guo-Li Li; Yan-Li Qi; Li-Yun Li; Lu-Fang Wang; Cong-Rong Wang; Xin-Rui Niu; Tao-Xue Liu; Jiang Wang; Guo-Yu Yang; Lei Zeng; Bei-Bei Chu
Source:
Viruses 2022 v.14 no.3 pp. -
ISSN:
1999-4915
Subject:
cholesterol; cholesterol metabolism,   etc   ; Suid alphaherpesvirus 1; agonists; homeostasis; liver; models;     Show all 7 Subjects
Abstract:
... Pseudorabies virus (PRV) is a contagious herpesvirus that causes Aujeszky’s disease and economic losses worldwide. Liver X receptors (LXRs) belong to the nuclear receptor superfamily and are critical for the control of lipid homeostasis. However, the role of LXR in PRV infection has not been fully established. In this study, we found that PRV infection downregulated the mRNA and protein levels of ...
DOI:
10.3390/v14030514

3. Emerging role of HDL in brain cholesterol metabolism and neurodegenerative disorders

Author:
Marta Turri; Cinzia Marchi; Maria Pia Adorni; Laura Calabresi; Francesca Zimetti
Source:
Biochimica et biophysica acta 2022 v.1867 no.5 pp. 159123
ISSN:
1388-1981
Subject:
cholesterol; cholesterol homeostasis,   etc   ; Alzheimer disease; Parkinson disease; astrocytes; brain; lipoproteins; therapeutics;     Show all 8 Subjects
Abstract:
... High-density lipoproteins (HDL) play a key role in cholesterol homeostasis maintenance in the central nervous system (CNS), by carrying newly synthesized cholesterol from astrocytes to neurons, to support their lipid-related physiological functions. As occurs for plasma HDL, brain lipoproteins are assembled through the activity of membrane cholesterol transporters, undergo remodeling mediated by s ...
DOI:
10.1016/j.bbalip.2022.159123

4. Control of Cholesterol Metabolism Using a Systems Approach

Author:
Dorota Formanowicz; Marcin Radom; Agnieszka Rybarczyk; Krzysztof Tanaś; Piotr Formanowicz
Source:
Biology 2022 v.11 no.3 pp. -
ISSN:
2079-7737
Subject:
cholesterol; cholesterol homeostasis,   etc   ; atherosclerosis; death; homeostasis; humans; inflammation; models; oxidative stress; therapeutics;     Show all 10 Subjects
Abstract:
... Cholesterol is an essential component of mammalian cells and is involved in many fundamental physiological processes; hence, its homeostasis in the body is tightly controlled, and any disturbance has serious consequences. Disruption of the cellular metabolism of cholesterol, accompanied by inflammation and oxidative stress, promotes the formation of atherosclerotic plaques and, consequently, is on ...
DOI:
10.3390/biology11030430

5. Inulin activates FXR-FGF15 signaling and further increases bile acids excretion in non-alcoholic fatty liver disease mice

Author:
Rui Wang; Yi Ren; Ting Bao; Ting Wang; Yiwei Li; Yuanyuan Liu; Xiaoxia Zhang; Shaoqi Yang; Hao Wang
Source:
Biochemical and biophysical research communications 2022 v.600 pp. 156-162
ISSN:
0006-291X
Subject:
cholesterol; cholesterol metabolism,   etc   ; alcohol drinking; bile; excretion; fatty liver; inflammation; inulin; mice; research;     Show all 10 Subjects
Abstract:
... Non-alcoholic fatty liver disease (NAFLD) is a metabolic disorder defined as the presence of intrahepatic lipid deposition and steatosis as well as chronic inflammation without excessive alcohol consumption. Our previous studies found that inulin could dramatically improve lipid metabolism disorders in NAFLD murine models. In recent years, mounting evidence has approved that there are disproportio ...
DOI:
10.1016/j.bbrc.2022.02.033

6. Nutrition-related mobile applications - should they be used for dietary prevention and treatment of cardiovascular diseases?

Author:
Aleksander Siniarski; Piotr Sobieraj; Piotr Samel-Kowalik; Beata Sińska; Magdalena Milewska; Agnieszka Bzikowska-Jura
Source:
Nutrition, metabolism, and cardiovascular diseases 2022 pp. -
ISSN:
0939-4753
Subject:
cholesterol,   etc   ; energy intake; metabolism;     Show all 3 Subjects
Abstract:
... There is no prior research on the usefulness that popular nutrition-related mobile applications would have on assessing fatty acids intake. In this study, we examine these applications through their utilization in the assessment of consumption of saturated (SFAs) and polyunsaturated (PUFAs) fatty acids against the Polish reference method (RM, Dieta 6.0). This report does also include the informati ...
DOI:
10.1016/j.numecd.2022.07.010

7. Two putative probiotic strains improve diet‐induced hypercholesterolemia through modulating intestinal cholesterol uptake and hepatic cholesterol efflux

Author:
Hongsup Yoon; Yuri Lee; Hye‐Ji Kang; Jaehyun Ju; Yosep Ji; Hyunjoon Park; Haryung Park; Heejae Lee; Wilhelm H. Holzapfel
Source:
Journal of applied microbiology 2022 v.132 no.1 pp. 562-570
ISSN:
1364-5072
Subject:
cholesterol; cholesterol metabolism,   etc   ; absorption; animal models; hypercholesterolemia; liver; low density lipoprotein; probiotics; small intestine;     Show all 9 Subjects
Abstract:
... AIMS: Two putative probiotic strains, Lacticaseibacillus (Lc.) rhamnosus BFE5264 and Lactiplantibacillus (Lp.) plantarum NR74, have been shown to suppress cholesterol uptake and promote cholesterol efflux in Caco‐2 cells. However, an in vivo beneficial effect of these strains on plasma cholesterol levels has not been verified yet; neither have the underlying mechanisms of regulating cholesterol me ...
DOI:
10.1111/jam.15181

8. Gut microbiome-mediated mechanisms for reducing cholesterol levels: Implications for ameliorating cardiovascular disease

Author:
Baolei Jia; Yuanqiang Zou; Xiao Han; Jin-Woo Bae; Che Ok Jeon
Source:
Trends in microbiology 2022 pp. -
ISSN:
0966-842X
Subject:
cholesterol; cholesterol metabolism,   etc   ; Bacteroides; Bifidobacterium; Lactobacillus; cardiovascular diseases; digestive system; intestinal microorganisms; probiotics; risk factors;     Show all 10 Subjects
Abstract:
... Cardiovascular disease (CVD) is a health problem worldwide and elevated cholesterol levels are a key risk factor for the disease. Dysbiotic gut microbiota has been shown to be associated with CVD development. However, the beneficial effects of healthy microbiota in decreasing cholesterol levels have not been summarized. Herein, we begin by discussing the potential mechanisms by which the gut micro ...
DOI:
10.1016/j.tim.2022.08.003

9. Validation of MEDFICTS Dietary Assessment Questionnaire in Turkish Population

Author:
Zeynep Göktaş; Derya Dikmen; Neslişah Rakıcıoğlu
Source:
Public health nutrition 2022 v.25 no.1 pp. 13-17
ISSN:
1475-2727
Subject:
National Cholesterol Education Program; cholesterol,   etc   ; adults; energy; fat intake; food records; nutrition assessment; public health; questionnaires;     Show all 9 Subjects
Abstract:
... The purpose of this study was to assess the validity of MEDFICTS (Meats, Eggs, Dairy, Fried foods, fat In baked goods, Convenience foods, fats added at the Table, Snacks) questionnaire in Turkish population. MEDFICTS questionnaire is a brief dietary assessment tool developed as part of the National Cholesterol Education Program Adult Treatment Panel guidelines, and it measures the adherence to Ste ...
DOI:
10.1017/S1368980021002299

10. Conformational Change from U- to I-Shape of Ion Transporters Facilitates K⁺ Transport across Lipid Bilayers

Author:
Mengyao Miao; Xueguang Shao; Wensheng Cai
Source:
Journal of physical chemistry 2022 v.126 no.7 pp. 1520-1528
ISSN:
1520-5207
Subject:
cholesterol,   etc   ; lipid bilayers; physical chemistry;     Show all 3 Subjects
Abstract:
... We have investigated, at the atomic level, the ion-fishing mechanism underlying the ion transport across membranes mediated by an artificial ion transporter composed of a hydroxyl-rich cholesterol group, a flexible alkyl chain, and a crown ether. Our results show that the transporter can spontaneously insert into the membrane and switch between the folded (U-shaped) and extended (I-shaped) conform ...
DOI:
10.1021/acs.jpcb.1c09423

11. Polyfunctional metabolic properties of the human strain Lactiplantibacillus plantarum Inducia (DSM 21379): Experimental and clinical approaches

Author:
Epp Songisepp; Jelena Stsepetova; Merle Rätsep; Liina Kuus; Anneli Piir; Kalle Kilk; Marika Mikelsaar
Source:
Journal of functional foods 2022 v.92 pp. 105064
ISSN:
1756-4646
Subject:
cholesterol; cholesterol metabolism,   etc   ; antioxidant activity; bile; biomarkers; blood; genes; genomics; humans; intestines; oxidative stress; polyamines; probiotics; yogurt;     Show all 14 Subjects
Abstract:
... The specific effectiveness of the Lactiplantibacillus plantarum strain Inducia of human intestinal origin was evaluated by genomic technologies, biochemical methods, and clinical biomarkers. The whole-genome sequence of L. plantarum Inducia harbored oxidative and lipid metabolism genes. The relevance of the assessed gene set to the functional properties of the strain in experimental research and t ...
DOI:
10.1016/j.jff.2022.105064

12. Amyloid beta increases ABCA1 and HMGCR protein expression, and cholesterol synthesis and accumulation in mice neurons and astrocytes

Author:
Shirin Azizidoost; Hossein Babaahmadi-Rezaei; Zahra Nazeri; Maryam Cheraghzadeh; Alireza Kheirollah
Source:
Biochimica et biophysica acta 2022 v.1867 no.1 pp. 159069
ISSN:
1388-1981
Subject:
cholesterol; cholesterol homeostasis,   etc   ; ABC transporters; Alzheimer disease; amyloid; apolipoprotein E; astrocytes; brain; cytochrome P-450; immunoblotting; protein synthesis;     Show all 11 Subjects
Abstract:
... Imbalanced cholesterol metabolism in the brain is one of the main pathophysiological mechanisms involved in Alzheimer's disease. We investigated the effect of amyloid-beta (Aβ) on the main proteins involved in regulation of cholesterol metabolism along with cholesterol content in astrocytes and neurons.Astrocytes and neurons were cultured and treated with Aβ. Apolipoprotein E (apoE) level in the c ...
DOI:
10.1016/j.bbalip.2021.159069

13. Dual targeted delivery of statins and nucleic acids by chitosan-based nanoparticles for enhanced antiatherosclerotic efficacy

Author:
Ting Jiang; Lu Xu; Mengxin Zhao; Fei Kong; Xinrong Lu; Cui Tang; Chunhua Yin
Source:
Biomaterials 2022 v.280 pp. 121324
ISSN:
0142-9612
Subject:
cholesterol metabolism; high density lipoprotein cholesterol,   etc   ; atherosclerosis; biocompatible materials; chitosan; cytokines; hepatocytes; inflammation; intravenous injection; macrophages; morbidity; mortality;     Show all 12 Subjects
Abstract:
... Cardiovascular disease caused by atherosclerosis is a leading cause of morbidity and mortality worldwide. Owing to the synergistic regulation of cholesterol metabolism and lesion inflammation, the simultaneous administration of statins and nucleic acids is expected to alleviate atherosclerosis. In this work, we prepared atorvastatin- and galactose-modified trimethyl chitosan nanoparticles (GTANPs) ...
DOI:
10.1016/j.biomaterials.2021.121324

14. An explanation for the decreased severity of liver malfunction in Niemann-Pick C1 disease with age

Author:
Robert P. Erickson; Lawrence I. Grossman; Siddhesh Aras
Source:
Journal of applied genetics 2022 v.63 no.3 pp. 469-474
ISSN:
1234-1983
Subject:
cholesterol,   etc   ; liver; liver diseases; mice; mitochondria;     Show all 5 Subjects
Abstract:
... Niemann-Pick C disease frequently presents as severe cholestatic disease in infants. However, it progressively becomes less of a problem as children age. We have found that, in an appropriate mouse model, liver cholesterol levels, which are initially very high, decrease while mitochondrial function, initially quite compromised, increases with age. The key mitochondrial regulator, MNRR1, increases ...
DOI:
10.1007/s13353-022-00695-y

15. A novel sterol-binding protein reveals heterogeneous cholesterol distribution in neurite outgrowth and in late endosomes/lysosomes

Author:
Akiko Yamaji-Hasegawa; Motohide Murate; Takehiko Inaba; Naoshi Dohmae; Masayuki Sato; Fumihiro Fujimori; Yasushi Sako; Peter Greimel; Toshihide Kobayashi
Source:
Cellular and molecular life sciences 2022 v.79 no.6 pp. 324
ISSN:
1420-682X
Subject:
cholesterol,   etc   ; endosomes; lipid composition; lysosomes; neurites;     Show all 5 Subjects
Abstract:
... We identified a mushroom-derived protein, maistero-2 that specifically binds 3-hydroxy sterol including cholesterol (Chol). Maistero-2 bound lipid mixture in Chol-dependent manner with a binding threshold of around 30%. Changing lipid composition did not significantly affect the threshold concentration. EGFP-maistero-2 labeled cell surface and intracellular organelle Chol with higher sensitivity t ...
DOI:
10.1007/s00018-022-04339-6

16. Crocetin exerts hypocholesterolemic effect by inducing LDLR and inhibiting PCSK9 and Sortilin in HepG2 cells

Author:
Aisha Siddiq A; Asha Martin
Source:
Nutrition research 2022 v.98 pp. 41-49
ISSN:
0271-5317
Subject:
cholesterol metabolism; low density lipoprotein cholesterol,   etc   ; carotenoids; cholesteremic effect; dose response; hepatoma; humans; hypercholesterolemia; nutrition research; protein synthesis; subtilisin;     Show all 11 Subjects
Abstract:
... Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an important post-transcriptional regulator of plasma levels of low-density lipoprotein cholesterol (LDL-C). Inhibition of PCSK9 has emerged as an attractive strategy in recent years to combat hypercholesterolemia stimulating the search for PCSK9 inhibitors. The carotenoid crocetin exhibits hypocholesterolemic effect. However, it is unknown ...
DOI:
10.1016/j.nutres.2021.08.005

17. HepG2 liver cells treated with fumonisin B₁ in galactose supplemented media have altered expression of genes and proteins known to regulate cholesterol flux

Author:
T. Adimulam; N.S. Abdul; A.A. Chuturgoon
Source:
World mycotoxin journal 2022 v.15 no.3 pp. 313-324
ISSN:
1875-0796
Subject:
cholesterol; cholesterol homeostasis,   etc   ; Crabtree effect; cell viability; galactose; gene expression; lipidomics; liver; luciferase; mitochondria; mycotoxicosis; protein synthesis; sphingolipids; toxicity;     Show all 14 Subjects
Abstract:
... Fumonisin B₁ (FB₁) contributes to mycotoxicosis in animals and has been associated with the incidence of some cancers in humans. The effect of FB₁ on lipidomic profiles, sphingolipids and cholesterol levels have been demonstrated in experimental models, however, the events leading to altered cholesterol levels are unclear. This study investigates the molecular mechanisms that regulate the effect o ...
DOI:
10.3920/WMJ2021.2723

18. Association between causative mutations and response to PCSK9 inhibitor therapy in subjects with familial hypercholesterolemia: A single center real-world study

Author:
Gabriella Iannuzzo; Alessio Buonaiuto; Ilenia Calcaterra; Marco Gentile; Francesco Forte; Maria Tripaldella; Maria D. Di Taranto; Carola Giacobbe; Giuliana Fortunato; Paolo O. Rubba; Matteo N. Dario Di Minno
Source:
Nutrition, metabolism, and cardiovascular diseases 2022 v.32 no.3 pp. 684-691
ISSN:
0939-4753
Subject:
high density lipoprotein cholesterol; low density lipoprotein cholesterol,   etc   ; genes; heterozygosity; homozygosity; hypercholesterolemia; low density lipoprotein receptors; metabolism; nutrition; subtilisin; therapeutics;     Show all 11 Subjects
Abstract:
... Familial hypercholesterolemia (FH) is an autosomal dominant disease that leads to cardiovascular (CV) disease. Proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9-I) demonstrated efficacy in low-density lipoprotein cholesterol (LDL-C) reduction and in prevention of CV events. The aim of our study is to evaluate the relationship between LDL receptor (LDLR) mutations and response to PCSK ...
DOI:
10.1016/j.numecd.2021.10.025

19. Enterocyte-specific ATGL overexpression affects intestinal and systemic cholesterol homeostasis

Author:
Melanie Korbelius; Nemanja Vujić; Katharina B. Kuentzel; Sascha Obrowsky; Silvia Rainer; Guenter Haemmerle; Thomas Rülicke; Dagmar Kratky
Source:
Biochimica et biophysica acta 2022 v.1867 no.4 pp. 159121
ISSN:
1388-1981
Subject:
cholesterol; cholesterol homeostasis,   etc   ; absorption; carboxylic ester hydrolases; catabolism; dietary fat; enterocytes; enzyme activity; fatty acids; homeostasis; liver; secretion; small intestine;     Show all 13 Subjects
Abstract:
... Enterocytes of the small intestine (SI) play an important role in maintaining systemic lipid levels by regulating dietary lipid absorption and postprandial lipoprotein secretion. An excessive amount of dietary-derived triglycerides (TGs) taken up by the apical side of enterocytes or basolaterally internalized lipoprotein remnants can be transiently stored in cytosolic lipid droplets (cLDs). As mic ...
DOI:
10.1016/j.bbalip.2022.159121

20. Lipid Variability and Risk of Cardiovascular Diseases and All-Cause Mortality: A Systematic Review and Meta-Analysis of Cohort Studies

Author:
Shuting Li; Leying Hou; Siyu Zhu; Qian Yi; Wen Liu; Yang Zhao; Feitong Wu; Xue Li; An Pan; Peige Song
Source:
Nutrients 2022 v.14 no.12 pp. -
ISSN:
2072-6643
Subject:
high density lipoprotein cholesterol; low density lipoprotein cholesterol,   etc   ; drug therapy; meta-analysis; monitoring; mortality; risk assessment; standard deviation; systematic review;     Show all 9 Subjects
Abstract:
... No consensus has yet been reached on the associations of lipid variability (LV) with cardiovascular diseases (CVDs) and all-cause mortality. We aimed to quantify the associations of different types and metrics of LV with CVDs and all-cause mortality. PubMed, Medline, and Embase databases were searched for eligible cohort studies published until 14 December 2021. Lipids included total cholesterol ( ...
DOI:
10.3390/nu14122450