U.S. flag

An official website of the United States government

PubAg

Main content area

You searched for: Subject "cholesterol" Remove constraint Subject: "cholesterol"
Start Over

Search

22,144  Search Results

« Previous | 1 - 20 of 22,144 |
Number of results to display per page

Search Results

1. Palladium-Catalyzed Three-Component Silylalkoxylation of 1,3-Diene with Alcohol and Disilane via Oxidative Coupling

Author:
Torii, Kazuyuki; Tabaru, Kazuki; Obora, Yasushi
Source:
Organic letters 2021 v.23 no.12 pp. 4898-4902
ISSN:
1523-7052
Subject:
cholesterol,   etc   ; benzyl alcohol; regioselectivity; silanes;     Show all 4 Subjects
Abstract:
... A regioselective and Z-selective three-component silylalkoxylation of 1,3-diene using various alcohols, disilane, and a catalytic Pd/Cu/1,4-benzoquinone/O₂ system is established in this Letter. The reaction generates tetra-substituted allyl silanes containing allyl ether moieties in up to 80% isolated yield and on a 1–10 mmol scale via oxidative coupling. A wide variety of substrates, including be ...
DOI:
10.1021/acs.orglett.1c01648

2. Illuminating endosomal escape of polymorphic lipid nanoparticles that boost mRNA delivery

Author:
Herrera, Marco; Kim, Jeonghwan; Eygeris, Yulia; Jozic, Antony; Sahay, Gaurav
Source:
Biomaterials science 2021 v.9 no.12 pp. 4289-4300
ISSN:
2047-4849
Subject:
cholesterol,   etc   ; biocompatible materials; endosomes; galectins; gene transfer;     Show all 5 Subjects
Abstract:
... Lipid-based nanoparticles (LNPs) for the delivery of mRNA have jumped to the forefront of non-viral gene delivery. Despite this exciting development, poor endosomal escape after LNP cell entry remains an unsolved, rate-limiting bottleneck. Here we report the use of a galectin 8-GFP (Gal8-GFP) cell reporter system to visualize the endosomal escape capabilities of LNP-encapsulated mRNA. LNPs substit ...
DOI:
10.1039/d0bm01947j

3. Pore-Spanning Plasma Membranes Derived from Giant Plasma Membrane Vesicles

Author:
Teiwes, Nikolas K.; Mey, Ingo; Baumann, Phila C.; Strieker, Lena; Unkelbach, Ulla; Steinem, Claudia
Source:
ACS applied materials & interfaces 2021 v.13 no.22 pp. 25805-25812
ISSN:
1944-8252
Subject:
cholesterol,   etc   ; fluorescence; plasma membrane; separation; silicon;     Show all 5 Subjects
Abstract:
... Giant plasma membrane vesicles (GPMVs) are a highly promising model system for the eukaryotic plasma membrane. The unresolved challenge, however, is a path to surface-based structures that allows accessibility to both sides of the plasma membrane through high-resolution techniques. Such an approach would pave the way to advanced chip-based technologies for the analysis of complex cell surfaces to ...
DOI:
10.1021/acsami.1c06404

4. A pilot study on the effects of transcutaneous and transmucosal laser irradiation on blood pressure, glucose and cholesterol in women

Author:
Lizarelli, Rosane de Fátima Zanirato; Grecco, Clovis; Regalo, Simone Cecilio Hallak; Esteban Florez, Fernando Luis; Bagnato, Vanderlei Salvador
Source:
Heliyon 2021 v.7 no.5 pp. e07110
ISSN:
2405-8440
Subject:
cholesterol,   etc   ; blood; blood pressure; glucose; irradiation;     Show all 5 Subjects
Abstract:
... The present pilot study had the objective to determine the effects of transcutaneous and transmucosal laser irradiation on arterial blood pressure (ABP), glucose (Glu) triglycerides (Tg), total cholesterol (Ch), high-density level cholesterol (HDL) and low-density cholesterol (LDL) immediately after treatment (T0) and after 30 (T30) and 60 (T60) days. Patients (n = 36) were selected and randomly d ...
DOI:
10.1016/j.heliyon.2021.e07110

5. Radical-mediated alkoxypolyhaloalkylation of styrenes with polyhaloalkanes and alcohols via C(sp³)–H bond cleavage

Author:
Liang, Yun-Yan; Huang, Jing; Ouyang, Xuan-Hui; Qin, Jing-Hao; Song, Ren-Jie; Li, Jin-Heng
Source:
Chemical communications 2021 v.57 no.30 pp. 3684-3687
ISSN:
1364-548X
Subject:
cholesterol,   etc   ; cleavage (chemistry); estrone; vitamin E;     Show all 4 Subjects
Abstract:
... We have developed a new radical-mediated alkoxypolyhaloalkylation of styrenes with polychloroalkanes and alcohols for the facile synthesis of complex polyhaloalkanes. 4-Methoxybenzenediazonium tetrafluoroborate is a good radical initiator for this transformation. This protocol is well applied to the late-stage functionalization of complex molecules, including vitamin E, estrone and cholesterol der ...
DOI:
10.1039/d1cc00400j

6. Mammalian ABCG-transporters, sterols and lipids: To bind perchance to transport?

Author:
Kerr, Ian D.; Hutchison, Ella; Gerard, Louise; Aleidi, Shereen M.; Gelissen, Ingrid C.
Source:
Biochimica et biophysica acta 2021 v.1866 no.3 pp. 158860
ISSN:
1388-1981
Subject:
cholesterol,   etc   ; drugs; homeostasis; mammals; microRNA; models;     Show all 6 Subjects
Abstract:
... Members of the ATP binding cassette (ABC) transporter family perform a critical function in maintaining lipid homeostasis in cells as well as the transport of drugs. In this review, we provide an update on the ABCG-transporter subfamily member proteins, which include the homodimers ABCG1, ABCG2 and ABCG4 as well as the heterodimeric complex formed between ABCG5 and ABCG8. This review focusses on p ...
DOI:
10.1016/j.bbalip.2020.158860

7. (r)HDL in theranostics: how do we apply HDL's biology for precision medicine in atherosclerosis management?

Author:
B. Uribe, Kepa; Benito-Vicente, Asier; Martin, Cesar; Blanco-Vaca, Francisco; Rotllan, Noemi
Source:
Biomaterials science 2021 v.9 no.9 pp. 3185-3208
ISSN:
2047-4849
Subject:
cholesterol; cholesterol metabolism,   etc   ; atherosclerosis; biocompatible materials; high density lipoprotein; homeostasis; liver; nanomedicine; precision medicine; risk;     Show all 10 Subjects
Abstract:
... High-density lipoproteins (HDL) are key players in cholesterol metabolism homeostasis since they are responsible for transporting excess cholesterol from peripheral tissues to the liver. Imbalance in this process, due to either excessive accumulation or impaired clearance, results in net cholesterol accumulation and increases the risk of cardiovascular disease (CVD). Therefore, significant effort ...
DOI:
10.1039/d0bm01838d

8. Food Chemistry of Selenium and Controversial Roles of Selenium in Affecting Blood Cholesterol Concentrations

Author:
Zhao, Meng; Luo, Ting; Zhao, Zixuan; Rong, Han; Zhao, Guohua; Lei, Lin
Source:
Journal of agricultural and food chemistry 2021 v.69 no.17 pp. 4935-4945
ISSN:
1520-5118
Subject:
cholesterol; cholesterol metabolism,   etc   ; bioavailability; blood; cholesteremic effect; dietary supplements; food chemistry; hypercholesterolemia; phytochemicals; public health; selenium;     Show all 11 Subjects
Abstract:
... Hypercholesterolemia, one of the major risk factors of cardiovascular diseases, is a worldwide public health problem. Nutraceuticals and phytochemicals are attracting attention as a result of their cholesterol-lowering ability and minimal side effects. Among them, selenium (Se) is on the list. The amount of Se in foods varies by region. Se-enriched fertilizers and feeds can raise the Se content in ...
DOI:
10.1021/acs.jafc.1c00784

9. Vaspin regulated cartilage cholesterol metabolism through miR155/LXRα and participated in the occurrence of osteoarthritis in rats

Author:
He, Hangyuan; Lu, Mengting; Shi, Huasong; Yue, Guoping; Luo, Hanwen
Source:
Life sciences 2021 v.269 pp. 119096
ISSN:
0024-3205
Subject:
cholesterol; cholesterol metabolism,   etc   ; cartilage; chondrocytes; collagen; liver; matrix metalloproteinase 13; osteoarthritis; papain; rats;     Show all 10 Subjects
Abstract:
... This study intends to explore the role of Vaspin and cholesterol metabolism in the process of osteoarthritis (OA) and its mechanism in vitro and in vivo.In vitro, chondrocytes were treated with interleukin-1β (IL-1β, 20 ng/mL) in combination with Vaspin at different concentrations for 48 h. The expressions of Aggrecan (ACAN), Collagen 2a1 (Col2a1), A Disintegrin And Metalloproteinase with Thrombo ...
DOI:
10.1016/j.lfs.2021.119096

10. Common Genetic Variations Involved in the Inter-Individual Variability of Circulating Cholesterol Concentrations in Response to Diets: A Narrative Review of Recent Evidence

Author:
Abdullah, Mohammad M. H.; Vazquez-Vidal, Itzel; Baer, David J.; House, James D.; Jones, Peter J. H.; Desmarchelier, Charles
Source:
Nutrients 2021 v.13 no.2
ISSN:
2072-6643
Subject:
cholesterol; cholesterol metabolism,   etc   ; area; biomarkers; blood lipids; cardiovascular diseases; risk; variability;     Show all 8 Subjects
Abstract:
... The number of nutrigenetic studies dedicated to the identification of single nucleotide polymorphisms (SNPs) modulating blood lipid profiles in response to dietary interventions has increased considerably over the last decade. However, the robustness of the evidence-based science supporting the area remains to be evaluated. The objective of this review was to present recent findings concerning the ...
DOI:
10.3390/nu13020695

11. Effects of different delivering matrices of β-glucan on lipids in mildly hypercholesterolaemic individuals: a meta-analysis of randomised controlled trials

Author:
Xu, Dengfeng; Liu, Hechun; Yang, Chao; Xia, Hui; Pan, Da; Yang, Xian; Yang, Ligang; Wang, Shaokang; Sun, Guiju
Source:
The British journal of nutrition 2021 v.125 no.3 pp. 294-307
ISSN:
1475-2662
Subject:
high density lipoprotein cholesterol; low density lipoprotein cholesterol,   etc   ; blood; hypercholesterolemia; meta-analysis; nutrition; people; risk reduction;     Show all 8 Subjects
Abstract:
... β-Glucan has been reported for its health benefits on blood lipids in hypercholesterolaemic individuals for years. However, people have paid little attention to the effects of β-glucan in populations with mild hypercholesterolaemia as well as the various delivering matrices. Our objective was to perform a meta-analysis to analyse the effects of β-glucan with different delivering matrices in mildly ...
DOI:
10.1017/S0007114520001610

12. Structural Basis of Low-pH-Dependent Lysosomal Cholesterol Egress by NPC1 and NPC2

Author:
Qian, Hongwu; Wu, Xuelan; Du, Ximing; Yao, Xia; Zhao, Xin; Lee, Joyce; Yang, Hongyuan; Yan, Nieng
Source:
Cell 2020 v.182 no.1 pp. 98-111.e18
ISSN:
0092-8674
Subject:
cholesterol,   etc   ; detergents; pH; proteins;     Show all 4 Subjects
Abstract:
... Lysosomal cholesterol egress requires two proteins, NPC1 and NPC2, whose defects are responsible for Niemann-Pick disease type C (NPC). Here, we present systematic structural characterizations that reveal the molecular basis for low-pH-dependent cholesterol delivery from NPC2 to the transmembrane (TM) domain of NPC1. At pH 8.0, similar structures of NPC1 were obtained in nanodiscs and in detergent ...
DOI:
10.1016/j.cell.2020.05.020

13. Effects of the number of days and the filling sequence of animal skin-bags used for the traditional production of Algerian Bouhezza raw goat cheese on physicochemical composition, α-tocopherol, cholesterol content and stability

Author:
Senoussi, Asma; Schadt, Iris; Saoudi, Zineddine; Zitoun Hamama, Ouarda Aissaoui; Zidoune, Mohammed Nasereddine; Carpino, Stefania; Marino, Vita Maria
Source:
International dairy journal 2021 v.119 pp. 105067
ISSN:
0958-6946
Subject:
cholesterol,   etc   ; alpha-tocopherol; animals; fermentation; goat cheese; oxidation; pH;     Show all 7 Subjects
Abstract:
... Traditional Algerian Bouhezza cheese is produced inside animal skin-bags with a fermented, buttermilk-like product, Lben. Two Bouhezza cheeses were simultaneously made in two skin-bags in each of two sequential years. Bags had a defined filling sequence (first or second) with Lben for the same batch. Samples from each bag were collected at days 7, 30 and 60 to obtain 6 samples per year and a total ...
DOI:
10.1016/j.idairyj.2021.105067

14. Distinctive functioning of STARD1 in the fetal Leydig cells compared to adult Leydig and adrenal cells. Impact of Hedgehog signaling via the primary cilium

Author:
Kothandapani, Anbarasi; Larsen, Michele Campaigne; Lee, Jinwoo; Jorgensen, Joan S.; Jefcoate, Colin R.
Source:
Molecular and cellular endocrinology 2021 v.531 pp. 111265
ISSN:
0303-7207
Subject:
cholesterol,   etc   ; Erinaceidae; adults; fish; histones; loci; microscopy; mitochondria; pregnenolone;     Show all 9 Subjects
Abstract:
... STARD1 stimulates cholesterol transfer to mitochondrial CYP11A1 for conversion to pregnenolone. A cholesterol-binding START domain is guided by an N-terminal domain in a cell selective manner. Fetal and adult Leydig cells (FLC, ALC) show distinct Stard1 regulation. sm- FISH microscopy, which resolves individual molecules of Stard1 mRNA, shows uniformly high basal expression in each FLC. In ALC, in ...
DOI:
10.1016/j.mce.2021.111265

15. Sterol Composition of the Peridinioid Dinoflagellate Zooxanthella nutricula, A Symbiont of Polycystine Radiolarians

Author:
Graeff, Jori E.; Leblond, Jeffrey D.
Source:
Protist 2021 v.172 no.3 pp. 125817
ISSN:
1434-4610
Subject:
cholesterol,   etc   ; Cnidaria; Heterocapsa; Symbiodinium; Zooxanthella; protists; symbionts; symbiosis;     Show all 8 Subjects
Abstract:
... Some dinoflagellates, such as Symbiodinium, are able to form symbiotic relationships with larger marine organisms. An important aspect of dinoflagellate symbiosis involves the exchange of lipids, namely sterols, from the symbiont to the host. Much research has explored the lipid biochemistry of the symbiotic relationship between cnidarians and Symbiodinium dinoflagellates. However, no research has ...
DOI:
10.1016/j.protis.2021.125817

16. Visualizing the osmotic water permeability of a lipid bilayer under measured bilayer tension using a moving membrane method

Author:
Yano, Keita; Iwamoto, Masayuki; Koshiji, Takaaki; Oiki, Shigetoshi
Source:
Journal of membrane science 2021 v.627 pp. 119231
ISSN:
0376-7388
Subject:
cholesterol,   etc   ; glass; gramicidin; lipid bilayers; permeability; quantitative analysis;     Show all 6 Subjects
Abstract:
... The water flux across the cell membrane is a fundamental physiological process ubiquitous to all cell types. For evaluating water permeability (Pf), volume changes of cells and vesicles have been employed to measure water flux. However, upon volume expansion, the membrane stretches, and Pf could vary with membrane tension changes. Moreover, local concentration polarization of solutes occurs at the ...
DOI:
10.1016/j.memsci.2021.119231

17. Visual Quantitative Detection of Glutathione and Cholesterol in Human Blood Based on the Thiol–Ene Click Reaction-Triggered Wettability Change of the Interface

Author:
Wang, Hao; Liu, Zhang; Xiao, Jing; Li, Chunxiang; Wang, Jinglun; Xiao, Xiaojuan; Huang, Haowen; Shrestha, Binita; Tang, Liang; Deng, Keqin; Zhou, Hu
Source:
Analytical chemistry 2021 v.93 no.19 pp. 7292-7299
ISSN:
1520-6882
Subject:
cholesterol,   etc   ; analytical chemistry; blood; capillarity; glass; glutathione; humans; thiols; wettability;     Show all 9 Subjects
Abstract:
... Herein, we proposed an innovative visual quantitative sensing strategy based on thiol–ene click chemistry and the capillary action principle. A triethoxyvinylsilane (VTEO)- or mercaptopropylsilatrane (MPS)-modified interface was prepared for analyte recognition. Target analyte molecules containing thiol groups or C═C double bonds are coupled to the VTEO- or MPS-modified inner surface of the glass ...
DOI:
10.1021/acs.analchem.1c00830

18. Nickel-Catalyzed Guerbet Type Reaction: C-Alkylation of Secondary Alcohols via Double (de)Hydrogenation

Author:
Babu, Reshma; Subaramanian, Murugan; Midya, Siba P.; Balaraman, Ekambaram
Source:
Organic letters 2021 v.23 no.9 pp. 3320-3325
ISSN:
1523-7052
Subject:
cholesterol,   etc   ; alkylation; catalytic activity; cross-coupling reactions; dehydrogenation; hydrogenation; nickel;     Show all 7 Subjects
Abstract:
... Acceptorless double dehydrogenative cross-coupling of secondary and primary alcohols under nickel catalysis is reported. This Guerbet type reaction provides an atom- and a step-economical method for the C-alkylation of secondary alcohols under mild, benign conditions. A broad range of substrates including aromatic, cyclic, acyclic, and aliphatic alcohols was well tolerated. Interestingly, the C-al ...
DOI:
10.1021/acs.orglett.1c00782

19. Uptake of Vitamins D2, D3, D4, D5, D6, and D7 Solubilized in Mixed Micelles by Human Intestinal Cells, Caco-2, an Enhancing Effect of Lysophosphatidylcholine on the Cellular Uptake, and Estimation of Vitamins D’ Biological Activities

Author:
Kotake-Nara, Eiichi; Komba, Shiro; Hase, Megumi
Source:
Nutrients 2021 v.13 no.4
ISSN:
2072-6643
Subject:
cholesterol,   etc   ; absorption; calcium; humans; intestines; lysophosphatidylcholine; micelles; prediction; solubilization;     Show all 9 Subjects
Abstract:
... Vitamins D have various biological activities, as well as intestinal calcium absorption. There has been recent concern about insufficient vitamin D intake. In addition to vitamins D₂ and D₃, there are lesser-known vitamins D₄–D₇. We synthesized vitamins D₅–D₇, which are not commercially available, and then evaluated and compared the mixed micelles-solubilized vitamins D uptake by Caco-2 cells. Exc ...
DOI:
10.3390/nu13041126

20. Antidepressant drugs act by directly binding to TRKB neurotrophin receptors

Author:
Casarotto, Plinio C.; Girych, Mykhailo; Fred, Senem M.; Kovaleva, Vera; Moliner, Rafael; Enkavi, Giray; Biojone, Caroline; Cannarozzo, Cecilia; Sahu, Madhusmita Pryiadrashini; Kaurinkoski, Katja; Brunello, Cecilia A.; Steinzeig, Anna; Winkel, Frederike; Patil, Sudarshan; Vestring, Stefan; Serchov, Tsvetan; Diniz, Cassiano R.A.F.; Laukkanen, Liina; Cardon, Iseline; Antila, Hanna; Rog, Tomasz; Piepponen, Timo Petteri; Bramham, Clive R.; Normann, Claus; Lauri, Sari E.; Saarma, Mart; Vattulainen, Ilpo; Castrén, Eero
Source:
Cell 2021 v.184 no.5 pp. 1299-1313.e19
ISSN:
0092-8674
Subject:
cholesterol,   etc   ; antidepressants; emotions; molecular dynamics; mutation; neuroplasticity; tyrosine;     Show all 7 Subjects
Abstract:
... It is unclear how binding of antidepressant drugs to their targets gives rise to the clinical antidepressant effect. We discovered that the transmembrane domain of tyrosine kinase receptor 2 (TRKB), the brain-derived neurotrophic factor (BDNF) receptor that promotes neuronal plasticity and antidepressant responses, has a cholesterol-sensing function that mediates synaptic effects of cholesterol. W ...
DOI:
10.1016/j.cell.2021.01.034