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1. Effects of obesity on cholesterol metabolism and its implications for healthy ageing

Author:
Mc Auley, Mark Tomás
Source:
Nutrition research reviews 2020 v.33 no.1 pp. 121-133
ISSN:
1475-2700
Subject:
cholesterol metabolism,   etc   ; elderly; morbidity; obesity; pandemic;     Show all 5 Subjects
Abstract:
... The last few decades have witnessed a global rise in the number of older individuals. Despite this demographic shift, morbidity within this population group is high. Many factors influence healthspan; however, an obesity pandemic is emerging as a significant determinant of older people’s health. It is well established that obesity adversely affects several metabolic systems. However, due to its cl ...
DOI:
10.1017/S0954422419000258

2. Osmotic-Tension-Induced Membrane Lateral Organization

Author:
Wongsirojkul, Nichaporn; Shimokawa, Naofumi; Opaprakasit, Pakorn; Takagi, Masahiro; Hamada, Tsutomu
Source:
Langmuir 2020 v.36 no.11 pp. 2937-2945
ISSN:
1520-5827
Subject:
cholesterol,   etc   ; fluorescence microscopy; physical phases; separation; temperature;     Show all 5 Subjects
Abstract:
... Alteration of lipid raft organization manifesting as phase separation is important for cellular processes, such as signaling and trafficking. Such behaviors and dynamics of lipid membranes can be affected by external stimuli including both physical and chemical stimuli. In this study, we focused on osmotic-tension-induced phase separation. The effects of osmotic tension on the phase behaviors of v ...
DOI:
10.1021/acs.langmuir.9b03893

3. Two-Dimensional Immiscible Domain of Cholesterol in the Lipid Bilayer Membrane Promotes Early Stage Calcification by Inducing Oriented Nucleation of Hydroxyapatite

Author:
Jing, Jie; Chen, Xuanyu; Meng, Zhiping; Su, Wenqiang; Liu, Yonghai; Zhang, Yue; Zhu, Huaxu; Yao, Weiwei; Fu, Tingming
Source:
Langmuir 2020 v.36 no.8 pp. 2136-2142
ISSN:
1520-5827
Subject:
cholesterol,   etc   ; biomineralization; calcification; crystallization; hydroxyapatite; lipid bilayers;     Show all 6 Subjects
Abstract:
... Biomineralization is characterized by the fact that the crystallization of inorganic minerals is guided by an in vivo biological interface. However, the interfaces that direct calcification are widely debated up to date. In this paper, it was found that the two-dimensional (2D) immiscible domain of cholesterol in the lipid bilayer can induce the deposition of calcium phosphate by rapidly promoting ...
DOI:
10.1021/acs.langmuir.9b03489

4. Contributions des bactéries commensales et de l’hôte à la cholestérolémie

Author:
Lesnik, Philippe
Source:
Cahiers de nutrition et de diététique 2020 v.55 no.1 pp. 39-46
ISSN:
0007-9960
Subject:
cholesterol; cholesterol homeostasis,   etc   ; diet; environmental factors; epidemiological studies; genetic factors; humans; intestinal microorganisms; metabolic diseases; variance;     Show all 10 Subjects
Abstract:
... Large interindividual variations in plasma cholesterol are traditionally related to genetic factors and the residual portion of their variance is attributed to environmental factors, including diet. Preclinical studies have suggested that the microbiota plays a key role in inflammatory and metabolic disorders. Alterations in gut microbiota composition in humans have also been linked to a variety o ...
DOI:
10.1016/j.cnd.2019.10.002

5. SREBP2‐STARD4 is involved in synthesis of cholesteryl ester stimulated by mono‐butyl phthalate in MLTC‐1 cells

Author:
Chen, Shanshan; Wang, Yidi; Zhang, Lulu; Hu, Yanhui; Gu, Chenxi; Wen, Yun; Gu, Aihua; Zhang, Jingshu; Wang, Yubang
Source:
Environmental toxicology 2020 v.35 no.3 pp. 377-384
ISSN:
1520-4081
Subject:
cholesterol; cholesterol homeostasis,   etc   ; cholesteryl esters; dibutyl phthalate; hydrolysis; males; mice; neoplasm cells; signal transduction; steroidogenesis;     Show all 10 Subjects
Abstract:
... Sterol is synthesized from cholesterol which is from the hydrolysis of stored cholesteryl esters. The process of maintaining cholesterol homeostasis is regulated by SREBP2‐STARD4. Lots of researches demonstrated that male steroidogenesis could be interfered by di‐n‐butyl phthalate (DBP) or monobutyl phthalate (MBP). However, mechanisms of MBP exposure in this process have not been uncovered clearl ...
DOI:
10.1002/tox.22874

6. High-resolution label-free studies of molecular distribution and orientation in ultrathin, multicomponent model membranes with infrared nano-spectroscopy AFM-IR

Author:
Lipiec, Ewelina; Wnętrzak, Anita; Chachaj-Brekiesz, Anna; Kwiatek, Wojciech; Dynarowicz-Latka, Patrycja
Source:
Journal of colloid and interface science 2019 v.542 pp. 347-354
ISSN:
0021-9797
Subject:
cholesterol,   etc   ; cyclosporine; models; sphingomyelins;     Show all 4 Subjects
Abstract:
... Biological membranes are undoubtedly very interesting systems. Unfortunately, their analysis is very complicated and therefore simplified artificial models, like Langmuir monolayers, are frequently applied. In this work a novel method of label-free monomolecular films analysis based on infrared nano-spectroscopy (AFM-IR) is presented. In order to verify applicability of this approach well-defined ...
DOI:
10.1016/j.jcis.2019.02.016

7. Nutrition, lipidic parameters, and cancer risk and progress

Author:
Boretti, Albert
Source:
Nutrition 2020 v.69 pp. 110538
ISSN:
0899-9007
Subject:
cholesterol,   etc   ; clinical nutrition; neoplasms; nutrition risk assessment; therapeutics;     Show all 5 Subjects
Abstract:
... The aim of this literature review is to analyze the association between lipidic parameters and cancer risk and progression, as there is no clear evidence that the risk or advancement of cancer increases with cholesterol levels. Some works suggest a positive, others a negative, and still others a neutral correlation between cancer advancement or risk and cholesterol-related parameters. This lack of ...
DOI:
10.1016/j.nut.2019.06.019

8. Supplementation of fermented coffee-peel flour to increase high-density lipoprotein (HDL) cholesterol, docosahexaenoic acids (DHA) and eicosapentaenoic acids (EPA) deposition in tilapia fillet

Author:
Fitria, Pingky D.; Amin, Muhamad; Lokapirnasari, Widya P.; Lamid, Mirni
Source:
Biocatalysis and agricultural biotechnology 2020 v.24 pp. 101502
ISSN:
1878-8181
Subject:
high density lipoprotein cholesterol; low density lipoprotein cholesterol,   etc   ; Coffea; Oreochromis niloticus; docosahexaenoic acid; eicosapentaenoic acid; fish fillets; flour; triacylglycerols;     Show all 9 Subjects
Abstract:
... This study aimed at investigating the effect of fermented coffee-peel (Coffea sp.) flour supplementation on the total cholesterol, low-density lipoprotein cholesterol (LDL-c), triglycerides, high-density lipoprotein cholesterol (HDL-c), docosahexaenoic acids (DHA), and eicosapentaenoic acids (EPA) contents in tilapia (Oreochromis niloticus) fillet. Five treatments with four replicates of each were ...
DOI:
10.1016/j.bcab.2020.101502

9. The effect of consumption of pork enriched by organic selenium on selenium status and lipid profile in blood serum of consumers

Author:
Mrázová, Jana; Gažarová, Martina; Kopčeková, Jana; Kolesárová, Anna; Bučko, Ondřej; Bobček, Branislav
Source:
Journal of environmental science and health 2020 v.55 no.1 pp. 69-74
ISSN:
1532-4109
Subject:
high density lipoprotein cholesterol; low density lipoprotein cholesterol,   etc   ; blood serum; feed intake; lipid composition; men; pork; selenium; triacylglycerols; women;     Show all 10 Subjects
Abstract:
... The aim of the research was to evaluate the effect of consumption of selenium-enriched pork on selected health indicators of probands. The intake of feed mixture with increased organic selenium at the dose of 0.3 mg.kg⁻¹ probably increases selenium concentration in MSM (musculus semimembranosus). In the pork enriched with organic selenium, the concentration was higher by 1.045 ± 0.10 mg.kg⁻¹ compa ...
DOI:
10.1080/03601234.2019.1653734

10. New Insights into Cholesterol Functions: A Friend or an Enemy?

Author:
Zampelas, Antonis; Magriplis, Emmanuella
Source:
Nutrients 2019 v.11 no.7
ISSN:
2072-6643
Subject:
cholesterol,   etc   ; animal-based foods; diet;     Show all 3 Subjects
Abstract:
... Cholesterol is a sterol synthesized by animal cells and is also a component of the diet, being present in food of animal origin [...] ...
DOI:
10.3390/nu11071645

11. Generation of new hepatocyte-like in vitro models better resembling human lipid metabolism

Author:
Pramfalk, Camilla; Jakobsson, Tomas; Verzijl, Cristy R.C.; Minniti, Mirko E.; Obensa, Clara; Ripamonti, Federico; Olin, Maria; Pedrelli, Matteo; Eriksson, Mats; Parini, Paolo
Source:
Biochimica et biophysica acta 2020 v.1865 no.6 pp. 158659
ISSN:
1388-1981
Subject:
cholesterol; cholesterol acyltransferase,   etc   ; apolipoprotein B; blood serum; cattle; genes; hepatocytes; hepatoma; human cell lines; human diseases; humans; lipid metabolism; models; phenotype; triacylglycerols;     Show all 15 Subjects
Abstract:
... In contrast to human hepatocytes in vivo, which solely express acyl-coenzyme A:cholesterol acyltransferase (ACAT) 2, both ACAT1 and ACAT2 (encoded by SOAT1 and SOAT2) are expressed in primary human hepatocytes and in human hepatoma cell lines. Here, we aimed to create hepatocyte-like cells expressing the ACAT2, but not the ACAT1, protein to generate a model that – at least in this regard – resembl ...
DOI:
10.1016/j.bbalip.2020.158659

12. Prebiotics may alter bile salt hydrolase activity: Possible implications for cholesterol metabolism

Author:
Adebola, Oluwakemi Obasola; Corcoran, Olivia; Morgan, Winston A.
Source:
PharmaNutrition 2020 v.12 pp. 100182
ISSN:
2213-4344
Subject:
cholesterol; cholesterol metabolism,   etc   ; Lactobacillus; bile salts; blood serum; catalytic activity; cholic acid; choloylglycine hydrolase; enzyme activity; excretion; gastrointestinal system; inulin; lactulose; liver; prebiotics; probiotics;     Show all 16 Subjects
Abstract:
... Probiotics secrete bile salt hydrolase (BSH) which catalyses the deconjugation and excretion of bile salts in the GI tract altering cholesterol metabolism in the liver. Many probiotic preparations include prebiotics to promote probiotic growth but little is understood about how prebiotics affect BSH activity. In this study the ability of probiotic Lactobacilli species to deconjugate bile salts in ...
DOI:
10.1016/j.phanu.2020.100182

13. Short-term exposure to air pollution and its interaction effects with two ABO SNPs on blood lipid levels in northern China: A family-based study

Author:
Wu, Yao; Tian, Yaohua; Wang, Mengying; Wang, Xiaowen; Wu, Junhui; Wang, Zijing; Hu, Yonghua
Source:
Chemosphere 2020 v.249 pp. 126120
ISSN:
0045-6535
Subject:
high density lipoprotein cholesterol; low density lipoprotein cholesterol,   etc   ; acute exposure; aerodynamics; air pollution; alleles; at-risk population; blood lipids; genetic background; models; particulates; single nucleotide polymorphism; triacylglycerols; China;     Show all 14 Subjects
Abstract:
... We examined the main effects of ambient particulate matters, as well as whether single-nucleotide polymorphisms (SNPs), located within ABO gene would modify the relationship. Data were collected from a family-based study conducted in Northern China. A generalized additive model with a Gaussian link and with each family as a stratum was applied to estimate the percentage change in blood lipid level ...
DOI:
10.1016/j.chemosphere.2020.126120

14. Effects of soy isoflavones on serum lipids and lipoprotein (a) in peritoneal dialysis patients

Author:
Yari, Zahra; Tabibi, Hadi; Najafi, Iraj; Hedayati, Mehdi; Movahedian, Mina
Source:
Nutrition, metabolism, and cardiovascular diseases 2020
ISSN:
0939-4753
Subject:
high density lipoprotein cholesterol; low density lipoprotein cholesterol,   etc   ; blood lipids; blood serum; cardiovascular diseases; dialysis; isoflavones; metabolism; patients; placebos; randomized clinical trials; triacylglycerols;     Show all 12 Subjects
Abstract:
... Lipid abnormalities are common in peritoneal dialysis (PD) patients and no effective treatment to decrease serum lipoprotein (a) [Lp(a)] in dialysis patients is known so far. Therefore, this research was designed to investigate the effects of soy isoflavone supplement on serum lipids and Lp(a) in PD patients.In this randomized, double-blind, placebo-controlled trial, 40 PD patients were randomly a ...
DOI:
10.1016/j.numecd.2020.04.023

15. Relationships of Lipids Profile with Health-Related Quality of Life in Chinese Centenarians

Author:
Wang, S.; Yang, S.; Jia, W.; Cao, W.; Han, K.; Liu, Miao; He, Y.
Source:
The journal of nutrition, health & aging 2020 v.24 no.4 pp. 404-411
ISSN:
1279-7707
Subject:
high density lipoprotein cholesterol; low density lipoprotein cholesterol,   etc   ; blood sampling; clinical examination; elderly; females; lipid composition; males; public health; quality of life; questionnaires; regression analysis; surveys; triacylglycerols; China;     Show all 15 Subjects
Abstract:
... OBJECTIVES: With the acceleration of the process of aging population, to enjoy a higher health-related quality of life (HRQoL) is the goal of the elderly population and public health. Studies on relationship between HRQoL and lipid profile through a large sample of representative elderly population are scare. OBJECTIVE: This study was conducted to firstly explore the relationships of lipid profile ...
DOI:
10.1007/s12603-020-1340-5

16. Impact of natural products on the cholesterol transporter ABCA1

Author:
Wang, Dongdong; Hiebl, Verena; Xu, Tao; Ladurner, Angela; Atanasov, Atanas G.; Heiss, Elke H.; Dirsch, Verena M.
Source:
Journal of ethnopharmacology 2020 v.249 pp. 112444
ISSN:
0378-8741
Subject:
cholesterol; cholesterol homeostasis,   etc   ; ABC transporters; Alzheimer disease; Oriental traditional medicine; active ingredients; alkaloids; amino acids; animal models; atherosclerosis; databases; homeopathic drugs; liver; pain; phenylpropanoids; polyketides; surveys; tannins; terpenoids;     Show all 19 Subjects
Abstract:
... In different countries and areas of the world, traditional medicine has been and is still used for the treatment of various disorders, including chest pain or liver complaints, of which we now know that they can be linked with altered lipid and cholesterol homeostasis. As ATP-binding cassette transporter A1 (ABCA1) plays an essential role in cholesterol metabolism, its modulation may be one of the ...
DOI:
10.1016/j.jep.2019.112444

17. Feed added curcumin with increased solubility on plasma lipoprotein, meat quality, and fat content in broiler chicks

Author:
Pornanek, Pitukpol; Phoemchalard, Chirasak
Source:
Tropical animal health and production 2020 v.52 no.2 pp. 647-652
ISSN:
0049-4747
Subject:
high density lipoprotein cholesterol; low density lipoprotein cholesterol,   etc   ; breast meat; broiler chickens; chicks; curcumin; dietary supplements; females; lipid content; males; meat quality; solubility; triacylglycerols; very low density lipoprotein;     Show all 14 Subjects
Abstract:
... The objective of this research was to investigate the effect of dietary supplementation of curcumin with increased solubility (CS: 0, 0.2, 0.4, 0.6, and 0.8% of diet) and broiler sex (males and females) on plasma lipoprotein concentrations, meat quality, and chemical composition in the breast meat (BM). A total of 240 1-day-old Arbor Acres chicks were randomly divided into ten groups, six replicat ...
DOI:
10.1007/s11250-019-02052-4

18. Glutamate affects cholesterol homeostasis within the brain via the up-regulation of CYP46A1 and ApoE

Author:
Zhang, Junjie; Zhang, Furong; Wu, Juan; Li, Jie; Yang, Zheqiong; Yue, Jiang
Source:
Toxicology 2020 v.432 pp. 152381
ISSN:
0300-483X
Subject:
cholesterol; cholesterol homeostasis,   etc   ; adults; chronic exposure; genes; glutamate receptors; glutamic acid; hippocampus; luciferase; messenger RNA; neurodegenerative diseases; neurons; neurotransmitters; subcutaneous injection; weaning;     Show all 15 Subjects
Abstract:
... Chronic glutamate excitotoxicity has been thought to be involved in numerous neurodegenerative disorders. A small but significant loss of membrane cholesterol has been reported following a short stimulation of ionotropic glutamate receptors (iGluRs). We investigated the alteration of brain cholesterol following chronic glutamate treatment. The alteration of cholesterol levels was evaluated in the ...
DOI:
10.1016/j.tox.2020.152381

19. Exploring the causal pathway from omega-6 levels to coronary heart disease: A network Mendelian randomization study

Author:
Liao, Li-zhen; Li, Wei-dong; Liu, Ying; Li, Jia-ping; Zhuang, Xiao-dong; Liao, Xin-xue
Source:
Nutrition, metabolism, and cardiovascular diseases 2020 v.30 no.2 pp. 233-240
ISSN:
0939-4753
Subject:
high density lipoprotein cholesterol; low density lipoprotein cholesterol,   etc   ; confidence interval; coronary disease; genetic variation; genome-wide association study; metabolism; odds ratio; risk factors; standard deviation; triacylglycerols;     Show all 11 Subjects
Abstract:
... Evidence on the effect of omega-6 fats on coronary heart disease (CHD) risk remains inconclusive. We applied a network MR framework to determine the causal effects between omega-6 levels and CHD and the potential cholesterol metabolic risk factors (Total cholesterol, TC; Low-density lipoprotein cholesterol, LDL-C; High-density lipoprotein cholesterol, HDL-C; Triglycerides, TG) which might act as m ...
DOI:
10.1016/j.numecd.2019.09.013

20. Berberine and Dyslipidemia: Different Applications and Biopharmaceutical Formulations Without Statin-Like Molecules—A Meta-Analysis

Author:
Bertuccioli, Alexander; Moricoli, Sara; Amatori, Stefano; Rocchi, Marco Bruno Luigi; Vici, Giorgia; Sisti, Davide
Source:
Journal of medicinal food 2020 v.23 no.2 pp. 101-113
ISSN:
1557-7600
Subject:
high density lipoprotein cholesterol; low density lipoprotein cholesterol,   etc   ; berberine; bioavailability; biopharmaceuticals; clinical trials; hyperlipidemia; meta-analysis; patients; silymarin; statistical models; systematic review; triacylglycerols;     Show all 13 Subjects
Abstract:
... The aim of this study was to analyze the efficacy of berberine taken alone or in other formulations (with silymarin or other mixtures) on dyslipidemia through a systematic review of the literature and a meta-analysis. A systematic investigation was conducted on 19 studies that were selected based on inclusion and exclusion criteria. Both controlled trials (n = 12) and cross-sectional trials (n = 7 ...
DOI:
10.1089/jmf.2019.0088