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1. Adapting to Rising Sea Levels: How Short-Term Responses Complement Long-Term Investment

Author:
Guthrie, G.
Source:
Environmental and resource economics 2021 v.78 no.4 pp. 635-668
ISSN:
0924-6460
Subject:
complement,   etc   ; infrastructure; models; sea level;     Show all 4 Subjects
Abstract:
... This paper presents a parsimonious model of a coastal locality’s adaptation to rising sea levels and uses the model to examine cost-minimizing policies involving two complementary approaches. One involves irreversible investment in sea walls and similar infrastructure. The other involves activities, such as beach scraping, that only provide temporary protection. Costs are minimized by delaying inv ...
DOI:
10.1007/s10640-021-00547-z

2. Can online discussions facilitate deep learning for students in General Education?

Author:
Aderibigbe, Semiyu Adejare
Source:
Heliyon 2021 v.7 no.3 pp. e06414
ISSN:
2405-8440
Subject:
complement,   etc   ; data collection; education; uncertainty;     Show all 4 Subjects
Abstract:
... Studies suggest that online discussions complement teaching and students' learning. However, research also indicates that some tutors and students are uncertain about the value and quality of the learning process in online discussions. The debate and uncertainty necessitate more studies on students' learning quality and depth in online discussions. Therefore, this study aimed to explore how the qu ...
DOI:
10.1016/j.heliyon.2021.e06414

3. How do rural extension agents learn? Argentine practitioners’ sources of learning and knowledge

Author:
Landini, Fernando
Source:
Thejournal of agricultural education and extension 2021 v.27 no.1 pp. 35-54
ISSN:
1750-8622
Subject:
complement,   etc   ; agricultural education; computer software;     Show all 3 Subjects
Abstract:
... Purpose: Extension workers’ knowledge and competencies are fundamental to a successful practice. Most academic literature focuses on how to train extension workers, but neglects how complex their learning processes are. This article contributes to the topic by describing and analyzing extension workers’ sources of knowledge and learning. Design/Methodology/approach: Twenty-four interviews and six ...
DOI:
10.1080/1389224X.2020.1780140

4. Complement component factor B has thrombin-like activity

Author:
Takahashi, Kazue; Banda, Nirmal K.; Holers, V. Michael; Van Cott, Elizabeth M.
Source:
Biochemical and biophysical research communications 2021 v.552 pp. 17-22
ISSN:
0006-291X
Subject:
complement,   etc   ; Limulus; coagulation; innate immunity; research; thrombin;     Show all 6 Subjects
Abstract:
... Serine proteases are fundamental components of biology, including innate immunity, which is systematically orchestrated in an orderly, balanced fashion in the healthy host. Such serine proteases are found in two well-recognized pathways of an innate immune network, coagulation and complement. Both pathways, if uncontrolled due to a variety of causes, are pathogenic in numerous diseases, including ...
DOI:
10.1016/j.bbrc.2021.02.134

5. Complement Proteins as Soluble Pattern Recognition Receptors for Pathogenic Viruses

Author:
Murugaiah, Valarmathy; Varghese, Praveen M.; Beirag, Nazar; De Cordova, Syreeta; Sim, Robert B.; Kishore, Uday
Source:
Viruses 2021 v.13 no.5
ISSN:
1999-4915
Subject:
complement,   etc   ; chemotaxis; lectins; pathogenesis; phagocytosis; virion;     Show all 6 Subjects
Abstract:
... The complement system represents a crucial part of innate immunity. It contains a diverse range of soluble activators, membrane-bound receptors, and regulators. Its principal function is to eliminate pathogens via activation of three distinct pathways: classical, alternative, and lectin. In the case of viruses, the complement activation results in effector functions such as virion opsonisation by ...
DOI:
10.3390/v13050824

6. Functional recombinant human complement C1q with different affinity tags

Author:
Bally, Isabelle; Ancelet, Sarah; Reiser, Jean-Baptiste; Rossi, Véronique; Gaboriaud, Christine; Thielens, Nicole M.
Source:
Journal of immunological methods 2021 v.492 pp. 113001
ISSN:
0022-1759
Subject:
complement,   etc   ; blood serum; humans; ligands; polypeptides; proteinases;     Show all 6 Subjects
Abstract:
... Complement C1q is a multifunctional protein able to sense pathogens and immune molecules such as immunoglobulins and pentraxins, and to trigger the classical complement pathway through activation of its two associated proteases, C1r and C1s. C1q is a multimeric protein composed of three homologous yet distinct polypeptide chains A, B, and C, each composed of an N-terminal collagen-like sequence an ...
DOI:
10.1016/j.jim.2021.113001

7. Human peripheral basophils extended phenotype shows a high expression of CD244 immuno-regulatory receptor

Author:
Berger, Anne-Emmanuelle; Durrieu, Coralie; Dzviga, Charles; Perrot, Jean-Luc; Lambert, Claude
Source:
Journal of immunological methods 2021 v.492 pp. 112951
ISSN:
0022-1759
Subject:
complement,   etc   ; humans; hypersensitivity; immunomodulation; neoplasms; phenotype;     Show all 6 Subjects
Abstract:
... Basophils play a major physio-pathological role in hypersensitivity related diseases. Basophils express high affinity Immunoglobulin (Ig) E receptors (FcεRI), IgG and complement regulatory. Basophils also have immunoregulatory activity through interaction with T cells. The aim of this study was to look for the expression of markers reflecting the activation status of peripheral Basophil in healthy ...
DOI:
10.1016/j.jim.2020.112951

8. Biochemical insights into structure and function of arrestins

Author:
Aydin, Yasmin; Coin, Irene
Source:
TheFEBS journal 2021 v.288 no.8 pp. 2529-2549
ISSN:
1742-464X
Subject:
complement,   etc   ; arrestins; computer simulation; crosslinking; mutagenesis;     Show all 5 Subjects
Abstract:
... Arrestins (arr) are multifunctional cytosolic adaptors that bind to active and phosphorylated G protein‐coupled receptors (GPCRs) via a highly versatile interface. Arrestins stop G protein signaling and trigger other signaling pathways. Recently, 3D structures of arr–GPCR complexes have been solved, which provide a bulk of structural information for understanding the mechanism of arr recruitment a ...
DOI:
10.1111/febs.15811

9. A temperature binning approach for multi-sector climate impact analysis

Author:
Sarofim, Marcus C.; Martinich, Jeremy; Neumann, James E.; Willwerth, Jacqueline; Kerrich, Zoe; Kolian, Michael; Fant, Charles; Hartin, Corinne
Source:
Climatic change 2021 v.165 no.1-2 pp. 22
ISSN:
0165-0009
Subject:
complement,   etc   ; climate; climate change; labor; recreation; temperature;     Show all 6 Subjects
Abstract:
... Characterizing the future risks of climate change is a key goal of climate impacts analysis. Temperature binning provides a framework for analyzing sector-specific impacts by degree of warming as an alternative or complement to traditional scenario-based approaches in order to improve communication of results, comparability between studies, and flexibility to facilitate scenario analysis. In this ...
DOI:
10.1007/s10584-021-03048-6

10. A water-function-based framework for understanding and governing water resilience in the Anthropocene

Author:
Falkenmark, Malin; Wang-Erlandsson, Lan
Source:
One earth 2021 v.4 no.2 pp. 213-225
ISSN:
2590-3322
Subject:
complement,   etc   ; Anthropocene epoch; climate; freshwater; governance; humans;     Show all 6 Subjects
Abstract:
... The freshwater cycle over land is fundamental for sustainability and resilience, yet is extensively modified and shaped by a vast range of human interventions in the land, water, and climate systems. The consequences of human water-cycle modifications can be non-linear, delayed, and distributed across boundaries, sectors, and scale. This complexity renders freshwater challenges difficult to govern ...
DOI:
10.1016/j.oneear.2021.01.009

11. Virus-Encoded Complement Regulators: Current Status

Author:
Sinha, Anwesha; Singh, Anup Kumar; Kadni, Trupti Satish; Mullick, Jayati; Sahu, Arvind
Source:
Viruses 2021 v.13 no.2
ISSN:
1999-4915
Subject:
complement,   etc   ; genome; immune system; selection pressure;     Show all 4 Subjects
Abstract:
... Viruses require a host for replication and survival and hence are subjected to host immunological pressures. The complement system, a crucial first response of the host immune system, is effective in targeting viruses and virus-infected cells, and boosting the antiviral innate and acquired immune responses. Thus, the system imposes a strong selection pressure on viruses. Consequently, viruses have ...
DOI:
10.3390/v13020208

12. Chemical synthesis and characterisation of the complement C5 inhibitory peptide zilucoplan

Author:
Gorman, Declan M.; Lee, John; Payne, Colton D.; Woodruff, Trent M.; Clark, Richard J.
Source:
Amino acids 2021 v.53 no.1 pp. 143-147
ISSN:
0939-4451
Subject:
complement,   etc   ; blood; humans; myasthenia gravis; peptides; synthesis;     Show all 6 Subjects
Abstract:
... The complement component C5 inhibitory peptide zilucoplan is currently in phase III clinical trials for myasthenia gravis (MG). Despite being at an advanced stage of clinical development, there have been no published reports in the literature detailing its chemical synthesis. In this work, we describe an approach for the chemical synthesis of zilucoplan and validate that the synthesised compound b ...
DOI:
10.1007/s00726-020-02921-5

13. Shape- and Orientation-Dependent Scattering of Isolated Gold Nanostructures Using Polarized Dark-Field Microscopy

Author:
Islam, Md Monirul; Hossen, Md Mir; Koschny, Thomas; Hillier, Andrew C.
Source:
Journal of physical chemistry 2021 v.125 no.21 pp. 11478-11488
ISSN:
1932-7455
Subject:
complement,   etc   ; color; electron microscopy; gold; nanorods; physical chemistry;     Show all 6 Subjects
Abstract:
... We demonstrate a simple and robust method for measuring the shape- and orientation-dependent optical scattering of various plasmonic nanostructures adsorbed onto a solid surface using polarized dark-field microscopy. By analyzing the dark-field scattering images of gold nanostructures using grazing incidence polarized light with a bench-top microscope, we are able to correlate optical scattering f ...
DOI:
10.1021/acs.jpcc.1c03671

14. PRE‐driven protein NMR structures: an alternative approach in highly paramagnetic systems

Author:
Trindade, Inês B.; Invernici, Michele; Cantini, Francesca; Louro, Ricardo O.; Piccioli, Mario
Source:
TheFEBS journal 2021 v.288 no.9 pp. 3010-3023
ISSN:
1742-464X
Subject:
complement,   etc   ; Rhodopseudomonas palustris; ambient temperature; databases; metalloproteins; oxidation; protein structure;     Show all 7 Subjects
Abstract:
... Metalloproteins play key roles across biology, and knowledge of their structure is essential to understand their physiological role. For those metalloproteins containing paramagnetic states, the enhanced relaxation caused by the unpaired electrons often makes signal detection unfeasible near the metal center, precluding adequate structural characterization right where it is more biochemically rele ...
DOI:
10.1111/febs.15615

15. The Ocean barcode atlas: A web service to explore the biodiversity and biogeography of marine organisms

Author:
Vernette, Caroline; Henry, Nicolas; Lecubin, Julien; de Vargas, Colomban; Hingamp, Pascal; Lescot, Magali
Source:
Molecular ecology resources 2021 v.21 no.4 pp. 1347-1358
ISSN:
1755-098X
Subject:
complement,   etc   ; ; Internet; barcoding; biogeography; latitude; oxygen; plankton; species diversity; temperature;     Show all 10 Subjects
Abstract:
... The Ocean Barcode Atlas (OBA) is a user friendly web service designed for biologists who wish to explore the biodiversity and biogeography of marine organisms locked in otherwise difficult to mine planetary scale DNA metabarcode data sets. Using just a web browser, a comprehensive picture of the diversity of a taxon or a barcode sequence is visualized graphically on world maps and interactive char ...
DOI:
10.1111/1755-0998.13322

16. Cerebral Microangiopathy in Two Dogs with Cutaneous and Renal Glomerular Vasculopathy

Author:
Pisco, Vera; Beck, Sam; Walker, Joshua JA.; Lopes, Bruno; Ives, Edward; Holm, Laura P.; Walker, David J.
Source:
Journal of comparative pathology 2021 v.184 pp. 95-100
ISSN:
0021-9975
Subject:
complement,   etc   ; brain; electrolytes; etiology; histopathology; humans; kidneys; microangiopathy; necrosis; pathophysiology;     Show all 10 Subjects
Abstract:
... Cutaneous and renal glomerular vasculopathy (CRGV) is an emerging disease in the UK, but its aetiology remains unclear. It is considered a thrombotic microangiopathy (TMA) in which the kidney and skin are the most commonly affected organs. We now document two cases of CRGV with brain lesions, which may have accounted for neurological signs displayed by these animals. The histopathological brain le ...
DOI:
10.1016/j.jcpa.2021.03.001

17. Searching for the toxic potential of Loxosceles amazonica and Loxosceles willianilsoni spiders’ venoms

Author:
Lopes, Priscila Hess; Fukushima, Caroline Sayuri; Shoji, Rosana; Bertani, Rogério; Tambourgi, Denise V.
Source:
Toxicon 2021 v.191 pp. 1-8
ISSN:
0041-0101
Subject:
complement,   etc   ; Loxosceles; cell death; enzymes; erythrocytes; humans; keratinocytes; toxicity; venoms;     Show all 9 Subjects
Abstract:
... The Loxosceles genus belongs to the Sicariidae family and it comprises species whose venom can cause accidents with potentially fatal consequences. We have previously shown that SMase D is the enzyme responsible for the main pathological effects of Loxosceles venom. Despite the severity of accidents with Loxosceles, few species are considered to be of medical importance. Little is known about the ...
DOI:
10.1016/j.toxicon.2020.12.006

18. Structure-Based Modeling of Complement C4 Mediated Neutralization of Adenovirus

Author:
Emerson, Corey C.; Stewart, Phoebe L.
Source:
Viruses 2021 v.13 no.1
ISSN:
1999-4915
Subject:
complement,   etc   ; capsid; coagulation; immune response; molecular dynamics; neutralization; thioesters; viruses;     Show all 8 Subjects
Abstract:
... Adenovirus (AdV) infection elicits a strong immune response with the production of neutralizing antibodies and opsonization by complement and coagulation factors. One anti-hexon neutralizing antibody, called 9C12, is known to activate the complement cascade, resulting in the deposition of complement component C4b on the capsid, and the neutralization of the virus. The mechanism of AdV neutralizati ...
DOI:
10.3390/v13010111

19. CH50 as a putative biomarker of eculizumab treatment in neuromyelitis optica spectrum disorder

Author:
Namatame, Chihiro; Misu, Tatsuro; Takai, Yoshiki; Nishiyama, Shuhei; Nakashima, Ichiro; Fujihara, Kazuo; Aoki, Masashi
Source:
Heliyon 2021 v.7 no.1 pp. e05899
ISSN:
2405-8440
Subject:
complement,   etc   ; biomarkers; blood serum; detection limit; drugs; patients;     Show all 6 Subjects
Abstract:
... Here we report 3 cases of neuromyelitis optica spectrum disorder (NMOSD), who were all treated with eculizumab and could be observed with monitoring serum C3, C4 and 50% hemolytic complement (CH50) before and after the treatment. Serum C3 and C4 were not dramatically changed during the treatment, in contrast serum CH50 level of each patient had diminished and kept under the detection limit after t ...
DOI:
10.1016/j.heliyon.2021.e05899

20. Evaluation and ranking of different gridded precipitation datasets for Satluj River basin using compromise programming and f-TOPSIS

Author:
Chowdhury, Bratati; Goel, N. K.; Arora, M.
Source:
Theoretical and applied climatology 2021 v.143 no.1-2 pp. 101-114
ISSN:
0177-798X
Subject:
complement,   etc   ; basins; climatology; data collection; rain; rivers; watersheds;     Show all 7 Subjects
Abstract:
... Accuracy of datasets is the prime challenge to climate-resilient water resources planning. The present study proposes a framework that combines deterministic and fuzzy scenario-based methods of ranking datasets. The framework was applied to rank gridded precipitation datasets for the Himalayan basin of the river Satluj using observed station data as reference. The Compromise Programming and Techni ...
DOI:
10.1007/s00704-020-03405-y