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1. Correction: Complement activation by gold nanoparticles passivated with polyelectrolyte ligands

Author:
Quach, Quang Huy; Kah, James Chen Yong
Source:
RSC advances 2018 v.8 no.15 pp. 8247
ISSN:
2046-2069
Subject:
complement,   etc   ; electrolytes; ligands; nanogold;     Show all 4 Subjects
Abstract:
... Correction for ‘Complement activation by gold nanoparticles passivated with polyelectrolyte ligands’ by Quang Huy Quach et al., RSC Adv., 2018, 8, 6616–6619. ...
DOI:
10.1039/c8ra90017e

2. A novel and sensitive functional assay for complement Factor I based on the third proteolytic clip of C3b

Author:
Lachmann, Peter J.; Lay, Elizabeth; Seilly, David J.
Source:
Journal of immunological methods 2018
ISSN:
0022-1759
Subject:
complement,   etc   ; ionic strength; proteolysis;     Show all 3 Subjects
Abstract:
... A sensitive assay for the functional activity of complement Factor I is described. This is based on its third proteolytic clip whereby Factor I cleaves cell-bound iC3b to cell-bound C3dg and soluble C3c, thereby abolishing conglutination of the cells. Factor H is required as a co-factor for Factor I activity. Because of the low affinity of iC3b for Factor H, the assay needs to be performed at low ...
DOI:
10.1016/j.jim.2018.03.013

3. Complement analysis in the era of targeted therapeutics

Author:
Prohászka, Zoltán; Kirschfink, Michael; Frazer-Abel, Ashley
Source:
Molecular immunology 2018
ISSN:
0161-5890
Subject:
complement,   etc   ; diagnostic techniques; fruits; therapeutics;     Show all 4 Subjects
Abstract:
... Complement immunobiology, and with it complement analysis, has undergone a renaissance in the past decade. Classically, complement analysis was limited number of testing C3, C4 in a routine laboratory with the possible addition of CH50 with all other analysis being performed at only few highly esoteric laboratories. This diagnostics expanding beyond specialized laboratories is the result of the gr ...
DOI:
10.1016/j.molimm.2018.06.001

4. The role of complement in antibody mediated transplant rejection

Author:
Thurman, Joshua M.; Panzer, Sarah E.; Le Quintrec, Moglie
Source:
Molecular immunology 2019 v.112 pp. 240-246
ISSN:
0161-5890
Subject:
complement,   etc   ; allografting; antibodies; antigens; drugs; graft rejection; pathogenesis; patients; risk;     Show all 9 Subjects
Abstract:
... Antibody mediated transplant rejection (AMR) is a major cause of long-term allograft failure, and currently available treatments are of limited efficacy for treating the disease. AMR is caused by donor specific antibodies (DSA) that bind to antigens within the transplanted organ. DSA usually activate the classical pathway of complement within the allograft, and complement activation is believed to ...
DOI:
10.1016/j.molimm.2019.06.002

5. Bispecific applications of non-immunoglobulin scaffold binders

Author:
Hober, Sophia; Lindbo, Sarah; Nilvebrant, Johan
Source:
Methods 2019 v.154 pp. 143-152
ISSN:
1046-2023
Subject:
complement,   etc   ; binding proteins; engineering; monoclonal antibodies; scaffolding proteins;     Show all 5 Subjects
Abstract:
... Non-immunoglobulin scaffolds represent a proven group of small affinity proteins that can be engineered in vitro to similar affinity and potency as monoclonal antibodies. Several novel candidate biotherapeutics that exploit the potential advantages scaffold proteins hold over larger and more complex antibodies have been developed over the past decade. The ease of using small and robust binding pro ...
DOI:
10.1016/j.ymeth.2018.09.010

6. Phagocytosis of live and dead Escherichia coli and Staphylococcus aureus in human whole blood is markedly reduced by combined inhibition of C5aR1 and CD14

Author:
Skjeflo, E.W.; Christiansen, D.; Landsem, A.; Stenvik, J.; Woodruff, T.M.; Espevik, T.; Nielsen, E.W.; Mollnes, T.E.
Source:
Molecular immunology 2019 v.112 pp. 131-139
ISSN:
0161-5890
Subject:
complement,   etc   ; Escherichia coli; Gram-positive bacteria; Staphylococcus aureus; antagonists; cytokines; flow cytometry; humans; inflammation; monocytes; phagocytosis;     Show all 11 Subjects
Abstract:
... Sepsis is a dysregulated host response to infection. The aim of this study was to investigate the effects of complement- and CD14 inhibition on phagocytosis of live and dead Gram-negative and Gram-positive bacteria in human whole blood.Lepirudin-anticoagulated blood was incubated with live or dead E. coli or S. aureus at 37 °C for 120 min with or without the C5aR1 antagonist PMX53 and/or anti-CD14 ...
DOI:
10.1016/j.molimm.2019.03.014

7. Soluble defense collagens: Sweeping up immune threats

Author:
Casals, Cristina; García-Fojeda, Belén; Minutti, Carlos M.
Source:
Molecular immunology 2019 v.112 pp. 291-304
ISSN:
0161-5890
Subject:
complement,   etc   ; adiponectin; blood serum; collagen; inflammation; macrophages; pathogens; phagocytosis; protein secretion; surfactant proteins; tissue repair;     Show all 11 Subjects
Abstract:
... Soluble defense collagens form a group of secreted proteins that are primarily involved in host defense. All defense collagens contain a globular recognition domain contiguous to a collagen-like triple helical domain. They are oligomeric proteins, assembled in multiples of three subunits due to their collagen domains. Members of this group include collectins such as surfactant protein A and D (SP- ...
DOI:
10.1016/j.molimm.2019.06.007

8. Structural characterization and anticomplement activity of an acidic polysaccharide containing 3-O-methyl galactose from Juniperus tibetica

Author:
Xia, Long; Li, Beibei; Lu, Yan; Chen, Daofeng
Source:
International journal of biological macromolecules 2019 v.132 pp. 1244-1251
ISSN:
0141-8130
Subject:
complement,   etc   ; Juniperus; branches; galactose; leaves; methylation; nuclear magnetic resonance spectroscopy; oligosaccharides; polysaccharides; water solubility;     Show all 10 Subjects
Abstract:
... A water-soluble acidic polysaccharide containing 3-O-methyl galactose, named YB-PS4, was isolated from the twigs and leaves of Juniperus tibetica Kom. Its structure was characterized by monosaccharide composition analysis, methylation, and NMR spectroscopy. It was concluded that YB-PS4 had a backbone composed of→2,4)-α-Rhap-(1→, →3,5)-α-Araf-(1→, →2,4)-α-Galp-(1 → and →4)-α-GalpA-(1→, with branche ...
DOI:
10.1016/j.ijbiomac.2019.04.029

9. Anti-inflammatory activity of intravenous immunoglobulin through scavenging of heme

Author:
Wiatr, Marie; Merle, Nicolas S.; Boudhabhay, Idris; Poillerat, Victoria; Rossini, Sofia; Lecerf, Maxime; Kaveri, Srini V.; Lacroix-Desmazes, Sébastian; Roumenina, Lubka T.; Dimitrov, Jordan D.
Source:
Molecular immunology 2019 v.111 pp. 205-208
ISSN:
0161-5890
Subject:
complement,   etc   ; anti-inflammatory activity; endothelial cells; heme; humans; immunoglobulins; immunomodulators; intravenous injection; therapeutics;     Show all 9 Subjects
Abstract:
... Therapeutic intravenous immunoglobulin preparations (IVIg) are used for treatment of wide range of autoimmune and inflammatory diseases. Versatile mechanisms have been reported to contribute to the immunomodulatory effects of IVIg. Here we demonstrate that IVIg has a strong potential to inhibit pro-inflammatory effect of extracellular heme. Indeed, the presence of immunoglobulins reduced the poten ...
DOI:
10.1016/j.molimm.2019.04.020

10. Endovascular trophoblast expresses CD59 to evade complement-dependent cytotoxicity

Author:
Ueda, Masashi; Sato, Yukiyasu; Horie, Akihito; Tani, Hirohiko; Miyazaki, Yumiko; Okunomiya, Asuka; Matsumoto, Hisanori; Hamanishi, Junzo; Kondoh, Eiji; Mandai, Masaki
Source:
Molecular and cellular endocrinology 2019 v.490 pp. 57-67
ISSN:
0303-7207
Subject:
complement,   etc   ; apoptosis; arteries; blood; cytotoxicity; embryo implantation; human cell lines; humans; tissues; trophoblast;     Show all 10 Subjects
Abstract:
... In the human placenta, extravillous trophoblasts (EVTs) invade maternal decidual tissues (interstitial trophoblasts) and maternal spiral arteries (endovascular trophoblasts). Although endovascular trophoblasts are directly exposed to maternal blood containing complement components, they are not eliminated by complement-dependent cytotoxicity (CDC). In this study, we investigated the expression and ...
DOI:
10.1016/j.mce.2019.04.006

11. Funding Global Environmental Public Goods Through Multilateral Financial Mechanisms

Author:
Chan, Nathan W.
Source:
Environmental and resource economics 2019 v.73 no.2 pp. 515-531
ISSN:
0924-6460
Subject:
complement,   etc   ; climate change; environmental quality; grants; models; public services and goods;     Show all 6 Subjects
Abstract:
... Multilateral financial mechanisms (MFMs) are becoming increasingly prevalent as a means for addressing global public good problems. MFMs raise funds from member countries through “burden sharing” arrangements, and these funds are disbursed as grants to finance environmental projects around the world. These projects are impure public goods, as they help achieve global (public) objectives like clima ...
DOI:
10.1007/s10640-018-0272-6

12. Complement therapeutics meets nanomedicine: overcoming human complement activation and leukocyte uptake of nanomedicines with soluble domains of CD55

Author:
Gifford, Geoffrey; Vu, Vivian P.; Banda, Nirmal K.; Holers, V. Michael; Wang, Guankui; Groman, Ernest V.; Backos, Donald; Scheinman, Robert; Moghimi, S. Moein; Simberg, Dmitri
Source:
Journal of controlled release 2019 v.302 pp. 181-189
ISSN:
0168-3659
Subject:
complement,   etc   ; engineering; humans; inhibitory concentration 50; intravenous injection; lectins; models; monocytes; nanomedicine; nanoparticles; neutrophils; pharmacokinetics; therapeutics;     Show all 13 Subjects
Abstract:
... Complement activation plays an important role in pharmacokinetic and performance of intravenously administered nanomedicines. Significant efforts have been directed toward engineering of nanosurfaces with low complement activation, but due to promiscuity of complement factors and redundancy of pathways, it is still a major challenge. Cell membrane-anchored Decay Accelerating Factor (DAF, a.k.a. CD ...
DOI:
10.1016/j.jconrel.2019.04.009

13. Supplementation of bovine follicular fluid during in vitro maturation increases oocyte cumulus expansion, blastocyst developmental kinetics, and blastocyst cell number

Author:
Lopes, Jordana Sena; Canha-Gouveia, Analuce; París-Oller, Evelynne; Coy, Pilar
Source:
Theriogenology 2019 v.126 pp. 222-229
ISSN:
0093-691X
Subject:
complement,   etc   ; blastocyst; cattle; cortical granules; embryogenesis; follicular fluid; heat treatment; in vitro fertilization; oocytes; survival rate;     Show all 10 Subjects
Abstract:
... Bovine follicular fluid (bFF) is the natural milieu for oocyte growth and development. However, its value as supplementation to in vitro maturation medium is still questioned due to inconsistent results. In this study we hypothesized that adding 10% of follicular fluid as well as heat treating it to inhibit the complement system, would produce higher quality embryos. To do so, experiments were con ...
DOI:
10.1016/j.theriogenology.2018.12.010

14. SERPING1 exon 3 splicing variants using alternative acceptor splice sites

Author:
Grymová, Tereza; Grodecká, Lucie; Souček, Přemysl; Freiberger, Tomáš
Source:
Molecular immunology 2019 v.107 pp. 91-96
ISSN:
0161-5890
Subject:
complement,   etc   ; blood cells; edema; exons; humans; liver; mutation; nucleotides; pathogenesis; stop codon;     Show all 10 Subjects
Abstract:
... Mutations in the C1 inhibitor (C1INH) encoding gene, SERPING1, are associated with hereditary angioedema (HAE) which manifests as recurrent submucosal and subcutaneous edema episodes. The major C1INH function is the complement system inhibition, preventing its spontaneous activation. The presented study is focused on SERPING1 exon 3, an alternative and extraordinarily long exon (499 bp). Endogenou ...
DOI:
10.1016/j.molimm.2019.01.007

15. Persistence of bactericidal antibodies 4 years after a booster dose of quadrivalent meningococcal diphtheria toxoid conjugate vaccine (MenACWY-D)

Author:
Robertson, Corwin A.; Hedrick, James; Bassily, Ehab; Greenberg, David P.
Source:
Vaccine 2019 v.37 no.8 pp. 1016-1020
ISSN:
0264-410X
Subject:
complement,   etc   ; adolescents; antibodies; blood serum; humans; risk; secondary immunization; vaccination; vaccines; young adults; United States;     Show all 11 Subjects
Abstract:
... One dose of quadrivalent meningococcal conjugate vaccine (MenACWY) was first recommended for US adolescents (ages 11–12 years) in 2005 to protect against invasive meningococcal disease (IMD). In 2010, after evidence emerged about waning protection within 5 years after MenACWY vaccination, the US Advisory Committee on Immunization Practices (ACIP) recommended a MenACWY booster at age 16 years. We u ...
DOI:
10.1016/j.vaccine.2019.01.008

16. Airborne Fine Particles Induce Hematological Effects through Regulating the Crosstalk of the Kallikrein-Kinin, Complement, and Coagulation Systems

Author:
Jin, Xiaoting; Ma, Qianchi; Sun, Zhendong; Yang, Xuezhi; Zhou, Qunfang; Qu, Guangbo; Liu, Qian; Liao, Chunyang; Li, Zhuoyu; Jiang, Guibin
Source:
Environmental science & technology 2019 v.53 no.5 pp. 2840-2851
ISSN:
1520-5851
Subject:
complement,   etc   ; air pollution; cardiovascular diseases; coagulation; homeostasis; lipopolysaccharides; particulates; prothrombin; risk; risk assessment;     Show all 10 Subjects
Abstract:
... Particulate air pollution caused by human activities has drawn global attention due to its potential health risks. Considering the inevitable contact of inhaled airborne fine particulate matter (PM) with plasma, the hematological effects of PM are worthy of study. In this study, the potential effect of PM on hematological homeostasis through triggering the crosstalk of the kallikrein-kinin system ...
DOI:
10.1021/acs.est.8b05817

17. Genetic Meningococcal Antigen Typing System (gMATS): A genotyping tool that predicts 4CMenB strain coverage worldwide

Author:
Muzzi, Alessandro; Brozzi, Alessandro; Serino, Laura; Bodini, Margherita; Abad, Raquel; Caugant, Dominique; Comanducci, Maurizio; Lemos, Ana Paula; Gorla, Maria Cecilia; Křížová, Pavla; Mikula, Claudia; Mulhall, Robert; Nissen, Michael; Nohynek, Hanna; Simões, Maria João; Skoczyńska, Anna; Stefanelli, Paola; Taha, Muhamed-Kheir; Toropainen, Maija; Tzanakaki, Georgina; Vadivelu-Pechai, Kumaran; Watson, Philip; Vazquez, Julio A.; Rajam, Gowrisankar; Rappuoli, Rino; Borrow, Ray; Medini, Duccio
Source:
Vaccine 2019 v.37 no.7 pp. 991-1000
ISSN:
0264-410X
Subject:
complement,   etc   ; antigens; blood serum; genotype; genotyping; humans; prediction; vaccines; England; Wales;     Show all 10 Subjects
Abstract:
... The Meningococcal Antigen Typing System (MATS) was developed to identify meningococcus group B strains with a high likelihood of being covered by the 4CMenB vaccine, but is limited by the requirement for viable isolates from culture-confirmed cases. We examined if antigen genotyping could complement MATS in predicting strain coverage by the 4CMenB vaccine.From a panel of 3912 MATS-typed invasive m ...
DOI:
10.1016/j.vaccine.2018.12.061

18. Aptamers that bind to the human complement component receptor hC5aR1 interfere with hC5aR1 interaction to its hC5a ligand

Author:
Kumar, Penmetcha K. R.
Source:
Molecular biology reports 2018 v.45 no.5 pp. 851-864
ISSN:
0301-4851
Subject:
complement,   etc   ; antibodies; chemotaxis; humans; immunity; inflammation; ligands; nucleotide aptamers;     Show all 8 Subjects
Abstract:
... The complement system plays an important role in inflammation and immunity. In this system, a potent inflammatory ligand is C5a, which initiates its effects by activating its core receptor C5aR1. Thus, compounds that interfere with the C5a–C5aR1 interaction could alleviate some inflammatory conditions. Consequently, several ligands that bind to either C5a or C5aR1 have previously been isolated and ...
DOI:
10.1007/s11033-018-4231-7

19. Identification of complement inhibitory activities of two chemotherapeutic agents using a high-throughput cell imaging-based screening assay

Author:
Zhang, Lingjun; Fedorov, Yuriy; Adams, Drew; Lin, Feng
Source:
Molecular immunology 2018 v.101 pp. 86-91
ISSN:
0161-5890
Subject:
complement,   etc   ; chemical compounds; cisplatin; drug therapy; monoclonal antibodies; screening;     Show all 6 Subjects
Abstract:
... Excessive complement activation contributes significantly to the pathogeneses of various diseases. Currently, significant developmental research efforts aim to identify complement inhibitors with therapeutic uses have led to the approval of one inhibitor for clinical use. However, most existing complement inhibitors are based on monoclonal antibodies, which have many drawbacks such as high costs a ...
DOI:
10.1016/j.molimm.2018.06.009

20. Semiparametrically efficient estimation in quantile regression of secondary analysis

Author:
Liang, Liang; Ma, Yanyuan; Wei, Ying; Carroll, Raymond J.
Source:
Journal of the Royal Statistical Society 2018 v.80 no.4 pp. 625-648
ISSN:
1369-7412
Subject:
complement,   etc   ; case-control studies; equations; models; regression analysis; risk;     Show all 6 Subjects
Abstract:
... Analysing secondary outcomes is a common practice for case–control studies. Traditional secondary analysis employs either completely parametric models or conditional mean regression models to link the secondary outcome to covariates. In many situations, quantile regression models complement mean‐based analyses and provide alternative new insights on the associations of interest. For example, biome ...
DOI:
10.1111/rssb.12272