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1. Emerging Insights into the Structure and Function of Complement C5a Receptors

Author:
Pandey, Shubhi; Maharana, Jagannath; Li, Xaria X.; Woodruff, Trent M.; Shukla, Arun K.
Source:
Trends in biochemical sciences 2020 v.45 no.8 pp. 693-705
ISSN:
0968-0004
Subject:
complement,   etc   ; G-proteins; agonists; arrestins; chemokine receptors; innate immunity;     Show all 6 Subjects
Abstract:
... Complement factor C5a is an integral constituent of the complement cascade critically involved in the innate immune response, and it exerts its functions via two distinct receptors, C5aR1 and C5aR2. While C5aR1 is a prototypical G-protein-coupled receptor (GPCR), C5aR2 lacks functional coupling to heterotrimeric G proteins, although both receptors efficiently recruit β arrestins (βarrs). Here, we ...
DOI:
10.1016/j.tibs.2020.04.004

2. Chemotherapy Induces Cancer-Fighting B Cells

Author:
Liu, Zhida; Fu, Yang-Xin
Source:
Cell 2020 v.180 no.6 pp. 1037-1039
ISSN:
0092-8674
Subject:
complement,   etc   ; B-lymphocytes; T-lymphocytes; drug therapy; immunity; neoplasms;     Show all 6 Subjects
Abstract:
... Tumor-infiltrating B cells are heterogeneous, and their roles in tumor immunity are controversial. In this issue of Cell, Lu and colleagues demonstrate that chemotherapy-induced complement signals promote the generation of ICOSL⁺B cells, which enhance tumor-specific T cell responses. ...
DOI:
10.1016/j.cell.2020.02.046

3. Anti-complementary activity of a degraded sulfated heterogalactan from red alga Pyropia haitanensis

Author:
Zhang, Zhongshan; Wang, Xiaomei; Lv, Fang; Xie, Xiaochao; Zhang, Shaoyong; Cai, Chuner; Jia, Rui; Pan, Yongliang; Liu, Feng
Source:
International journal of biological macromolecules 2020 v.147 pp. 527-533
ISSN:
0141-8130
Subject:
complement,   etc   ; Pyropia; molecular weight; nuclear magnetic resonance spectroscopy; polysaccharides; sulfates;     Show all 6 Subjects
Abstract:
... A sulfated galactan LP-G2 was isolated and purified from red alga, Pyropia haitanensis. It was a branched polysaccharide with average molecular weight about 8381 Da, composed of Gal, Glc, GalA and Ara. The structure of LP-G2 was determined using IR and NMR spectroscopy. It was composed of →4)-β-d-galactose→4)-α-l-galactose-6- sulfate segments, with β-d-Glc and α-d-galactose unit substituted at the ...
DOI:
10.1016/j.ijbiomac.2020.01.045

4. Malaria in Pregnancy and Adverse Birth Outcomes: New Mechanisms and Therapeutic Opportunities

Author:
Ngai, Michelle; Weckman, Andrea M.; Erice, Clara; McDonald, Chloe R.; Cahill, Lindsay S.; Sled, John G.; Kain, Kevin C.
Source:
Trends in parasitology 2020 v.36 no.2 pp. 127-137
ISSN:
1471-4922
Subject:
complement,   etc   ; biogenesis; heme; malaria; pregnancy complications; pregnancy outcome; therapeutics;     Show all 7 Subjects
Abstract:
... Malaria infection during pregnancy is associated with adverse birth outcomes but underlying mechanisms are poorly understood. Here, we discuss the impact of malaria in pregnancy on three pathways that are important regulators of healthy pregnancy outcomes: L-arginine-nitric oxide biogenesis, complement activation, and the heme axis. These pathways are not mutually exclusive, and they collectively ...
DOI:
10.1016/j.pt.2019.12.005

5. The Past and Future of Experimental Speciation

Author:
White, Nathan J.; Snook, Rhonda R.; Eyres, Isobel
Source:
Trends in ecology & evolution 2020 v.35 no.1 pp. 10-21
ISSN:
0169-5347
Subject:
complement,   etc   ; evolution; gene flow; reproductive isolation; theoretical models;     Show all 5 Subjects
Abstract:
... Speciation is the result of evolutionary processes that generate barriers to gene flow between populations, facilitating reproductive isolation. Speciation is typically studied via theoretical models and snapshot tests in natural populations. Experimental speciation enables real-time direct tests of speciation theory and has been long touted as a critical complement to other approaches. We argue t ...
DOI:
10.1016/j.tree.2019.08.009

6. Urease immobilized GO core@shell heparin-mimicking polymer beads with safe and effective urea removal for blood purification

Author:
Zhang, Jue; Shi, Zhenqiang; He, Chao; Song, Xin; Yang, Ye; Sun, Shudong; Zhao, Weifeng; Zhao, Changsheng
Source:
International journal of biological macromolecules 2020 v.156 pp. 1503-1511
ISSN:
0141-8130
Subject:
complement,   etc   ; adsorbents; adsorption; biocompatibility; blood; graphene oxide; hemolysis; polymers; toxins; urea; urease;     Show all 11 Subjects
Abstract:
... Adsorbents are usually used to remove uremic toxins for blood purification. However, the removal of urea is still an intractable problem, since no effective material has been found for urea removal by physical adsorption. Here, urease immobilized graphene oxide core@shell heparin-mimicking polymer (U-GO-HMP) beads were designed, which exhibited good urea removal ability with a removal amount of ab ...
DOI:
10.1016/j.ijbiomac.2019.11.197

7. Structural characterization and anticomplement activity of an acidic polysaccharide from Hedyotis diffusa

Author:
Huo, Jiangyan; Lu, Yan; Jiao, Yukun; Chen, Daofeng
Source:
International journal of biological macromolecules 2020 v.155 pp. 1553-1560
ISSN:
0141-8130
Subject:
complement,   etc   ; 2,2-diphenyl-1-picrylhydrazyl; Oldenlandia diffusa; antioxidant activity; free radicals; polysaccharides; uronic acids;     Show all 7 Subjects
Abstract:
... An acidic homogeneous polysaccharide (HD-PS-1) was purified from Hedyotis diffusa (Willd.) Roxb. HD-PS-1 possessed a backbone chain of →[4)-β-Glcp-3-OAc-(1]₆→[6)-β-Manp-(1]₂→6)-α-Galp-(1→[4)-α-Galp-(1]₂→, with three branches of β-Manp-(1→3)-β-GlcpA, α-Rhap-(1→3)-α-Rhap and α-Galp attached to the backbone chain at O-4 position of 1,4,6-linked β-Manp, O-3 position of 1,3,6-linked α-Galp and O-3 posi ...
DOI:
10.1016/j.ijbiomac.2019.11.132

8. Development of a microsphere‐based immunoassay for the serological detection of glanders in equids

Author:
Laroucau, K.; Saqib, M.; Martin, B.; Deshayes, T.; Bertin, C.; Wernery, U.; Joseph, S.; Singha, H.; Tripathi, B.N.; Beck, C.
Source:
Acta tropica 2020 v.207 pp. 105463
ISSN:
0001-706X
Subject:
complement fixation tests,   etc   ; Burkholderia mallei; Equidae; antigens; etiological agents; glanders; horses; recombinant proteins; serodiagnosis; India; Pakistan;     Show all 11 Subjects
Abstract:
... Burkholderia mallei is the etiologic agent of glanders, an infectious disease of solipeds, with renewed scientific interest due to its increasing incidence in different parts of the world. More rapid, sensitive and specific assays are required by laboratories for confirmatory testing of this disease. A microsphere‐based immunoassay consisting of beads coated with B. mallei recombinant proteins (Bi ...
DOI:
10.1016/j.actatropica.2020.105463

9. Immunogenicity and safety of a quadrivalent meningococcal tetanus toxoid-conjugate vaccine (MenACYW-TT) in ≥56-year-olds: A Phase III randomized study

Author:
Esteves-Jaramillo, Alejandra; Koehler, Timothy; Jeanfreau, Robert; Neveu, David; Jordanov, Emilia; Singh Dhingra, Mandeep
Source:
Vaccine 2020 v.38 no.28 pp. 4405-4411
ISSN:
0264-410X
Subject:
complement,   etc   ; antibodies; blood serum; humans; immunogenicity; mortality; polysaccharides; rabbits; serotypes; tetanus; vaccines; Puerto Rico; United States;     Show all 13 Subjects
Abstract:
... Invasive meningococcal disease has a high mortality rate in individuals aged ≥56 years, but no vaccine is currently licensed in the USA for this age group. This study assessed the safety and immunogenicity of an investigational quadrivalent meningococcal tetanus toxoid conjugate vaccine (MenACYW-TT) compared with a meningococcal quadrivalent polysaccharide vaccine (MPSV4) in this age group.This wa ...
DOI:
10.1016/j.vaccine.2020.04.067

10. Dysregulation of complement system during pregnancy in patients with preeclampsia: A prospective study

Author:
He, Ying-dong; Xu, Bing-ning; Wang, Meng-lu; Wang, Ya-qin; Yu, Feng; Chen, Qian; Zhao, Ming-hui
Source:
Molecular immunology 2020 v.122 pp. 69-79
ISSN:
0161-5890
Subject:
complement,   etc   ; blood sampling; pathogenesis; patients; pre-eclampsia; pregnancy; prospective studies; women;     Show all 8 Subjects
Abstract:
... Recent studies have shown that aberrant activation of the complement system plays an important role in the pathogenesis of preeclampsia. There is evidence to suggest that aberrant activation of the complement system may already be present during the first trimester. Here, we performed a prospective study in which peripheral blood samples were collected from 500 women during pregnancy. Twenty-one p ...
DOI:
10.1016/j.molimm.2020.03.021

11. Long-term antibody persistence after a booster dose of quadrivalent meningococcal ACWY-tetanus toxoid conjugate vaccine in healthy 5-year-old children

Author:
Vesikari, Timo; Forsten, Aino; Laudat, France; Li, Ping; Van Der Wielen, Marie; Hezareh, Marjan; Perez, John L.; Webber, Chris
Source:
Vaccine 2020 v.38 no.22 pp. 3902-3908
ISSN:
0264-410X
Subject:
complement,   etc   ; Corynebacterium diphtheriae; antibodies; blood serum; children; humans; rabbits; serotypes; tetanus; vaccination; vaccines;     Show all 11 Subjects
Abstract:
... To provide continuing protection, available meningococcal vaccines must provide long-term persistence of circulating functional antibodies against prevalent serogroups causing invasive meningococcal disease (IMD). This study assessed antibody persistence and safety of the quadrivalent meningococcal vaccine conjugated to tetanus toxoid (MenACWY-TT) and the meningococcal serogroup C vaccine conjugat ...
DOI:
10.1016/j.vaccine.2020.02.030

12. Characterization and expression analysis of the C8α and C9 terminal complement components from pufferfish (Takifugu rubripes)

Author:
Hua, Xin-tong; Fan, Kunpeng; Zhang, Zhiqiang; Li, Xiaohao; Xia, Yuqing; Liu, Peng-fei; Liu, Ying
Source:
Developmental and comparative immunology 2020 v.106 pp. 103634
ISSN:
0145-305X
Subject:
complement,   etc   ; Takifugu rubripes; complementary DNA; eggs; gene expression; genes; innate immunity; lipopolysaccharides; liver; nucleotide sequences; tissues;     Show all 11 Subjects
Abstract:
... C8α and C9 mediate the membrane attack complex formation and bacterial lysis and are important components in the complement system. The cDNA sequences of the C8α and C9 genes were cloned from Takifugu rubripes. The full-length cDNA of Tr-C8α was 1893 bp and included a 5′-UTR of 69 bp and 3′-UTR of 83 bp. The full-length cDNA of Tr-C9 was 2083 bp and included a 5′-UTR of 72 bp and 3′-UTR of 250 bp. ...
DOI:
10.1016/j.dci.2020.103634

13. Repeatable behavioural and immune defence strategies against infection are not traded off

Author:
Schreier, Katharina C.; Grindstaff, Jennifer L.
Source:
Animal behaviour 2020 v.162 pp. 11-22
ISSN:
0003-3472
Subject:
complement,   etc   ; Taeniopygia guttata; antibodies; avoidance behavior; birds; corticosterone; developmental stages; haptoglobins; immune response; lipopolysaccharides;     Show all 10 Subjects
Abstract:
... Disease exposure is a threat to all organisms, but there are a number of methods of self-defence. First, individuals can proactively prevent disease through avoidance behaviours. If they become infected, individuals can activate an immune response to control the infection. A trade-off between avoidance behaviours and immune response activation has been hypothesized to occur because of costs associ ...
DOI:
10.1016/j.anbehav.2020.01.008

14. Serum complement C1q level is associated with acute coronary syndrome

Author:
Ni, Xiao-ning; Yan, Sen-bo; Zhang, Ke; Sai, Wen-wen; Zhang, Qi-yu; Ti, Yun; Wang, Zhi-hao; Zhang, Wei; Zheng, Chun-yan; Zhong, Ming
Source:
Molecular immunology 2020 v.120 pp. 130-135
ISSN:
0161-5890
Subject:
complement,   etc   ; angiography; atherosclerosis; blood serum; drinking; immunity; myocardial infarction; patients; regression analysis; risk; turbidity;     Show all 11 Subjects
Abstract:
... The complement system plays an important role in the development of acute coronary syndrome (ACS). Complement C1q is an important initial component of the classical complement pathway and closely related to many chronic inflammatory diseases, including atherosclerosis (AS). We aimed to determine whether there was association between serum complement C1q and the severity of coronary stenosis.320 pa ...
DOI:
10.1016/j.molimm.2020.02.012

15. Natural IgM dominates in vivo performance of liposomes

Author:
Ding, Tianhao; Guan, Juan; Wang, Mengke; Long, Qianqian; Liu, Xia; Qian, Jun; Wei, Xiaoli; Lu, Weiyue; Zhan, Changyou
Source:
Journal of controlled release 2020 v.319 pp. 371-381
ISSN:
0168-3659
Subject:
complement,   etc   ; blood circulation; blood plasma; drug therapy; immunoglobulin G; immunoglobulin M; monitoring; neoplasms; patients;     Show all 9 Subjects
Abstract:
... Prevalent deposition of plasma proteins on nano-surface alters the synthetic identity of liposomes in blood circulation. The key plasma protein(s) that can dominate in vivo fate of liposomes are of central importance for preclinical design and precise medication of liposome-based therapeutics. Herein, natural IgM, but not IgG, is identified to ubiquitously absorb on liposomal surface and takes the ...
DOI:
10.1016/j.jconrel.2020.01.018

16. Evidence for regulation of the complement system during pregnancy being ancient and conserved in mammals

Author:
Hansen, Victoria L.; Miller, Robert D.
Source:
Developmental and comparative immunology 2020 v.104 pp. 103562
ISSN:
0145-305X
Subject:
complement,   etc   ; Monodelphis domestica; extraembryonic membranes; humans; immune system; ovipary; parturition; pregnancy;     Show all 8 Subjects
Abstract:
... Here we demonstrate that regulation of the Complement (C′) components of the immune system is an ancient and conserved feature of mammalian pregnancy. Transcript levels were reduced for complement components C3 and C4 throughout pregnancy in a marsupial, Monodelphis domestica. Downstream C′ component transcripts were significantly less abundant relative to non-pregnant controls at the start of pre ...
DOI:
10.1016/j.dci.2019.103562
PubMed:
31785265
PubMed Central:
PMC6937380

17. Functional analysis of the three major PGRPLC isoforms in the midgut of the malaria mosquito Anopheles coluzzii

Author:
Rodgers, Faye H.; Cai, Julia A.; Pitaluga, Andre N.; Mengin-Lecreulx, Dominique; Gendrin, Mathilde; Christophides, George K.
Source:
Insect biochemistry and molecular biology 2020 v.118 pp. 103288
ISSN:
0965-1748
Subject:
complement,   etc   ; Anopheles gambiae; Drosophila; bacteria; bacterial infections; elicitors; immunity; insects; malaria; midgut; models; peptidoglycans; polymers; proteins;     Show all 14 Subjects
Abstract:
... Peptidoglycan recognition proteins (PGRPs) constitute the primary means of bacterial recognition in insects. Recent work in the model organism Drosophila has revealed the mechanisms by which the complement of PGRPs refine the sensitivity of different tissues to bacterial elicitors, permitting the persistence of commensal bacteria in the gut whilst maintaining vigilance against bacterial infection. ...
DOI:
10.1016/j.ibmb.2019.103288

18. Click Chemistry in Proteomic Investigations

Author:
Parker, Christopher G.; Pratt, Matthew R.
Source:
Cell 2020 v.180 no.4 pp. 605-632
ISSN:
0092-8674
Subject:
complement,   etc   ; chemical reactions; drugs; mass spectrometry; metabolites; post-translational modification; proteins; proteome; proteomics;     Show all 9 Subjects
Abstract:
... Despite advances in genetic and proteomic techniques, a complete portrait of the proteome and its complement of dynamic interactions and modifications remains a lofty, and as of yet, unrealized, objective. Specifically, traditional biological and analytical approaches have not been able to address key questions relating to the interactions of proteins with small molecules, including drugs, drug ca ...
DOI:
10.1016/j.cell.2020.01.025
PubMed:
32059777
PubMed Central:
PMC7087397

19. Complement fragments are biomarkers of antibody-mediated endothelial injury

Author:
Stites, Erik; Renner, Brandon; Laskowski, Jennifer; Le Quintrec, Moglie; You, Zhiying; Freed, Brian; Cooper, James; Jalal, Diana; Thurman, Joshua M.
Source:
Molecular immunology 2020 v.118 pp. 142-152
ISSN:
0161-5890
Subject:
complement,   etc   ; allografting; antibodies; barium; biomarkers; biopsy; blood serum; endothelial cells; humans; kidney transplant; kidneys; models; patients;     Show all 13 Subjects
Abstract:
... Antibody-mediated rejection (AbMR) adversely affects long-term graft survival in kidney transplantation. Currently, the diagnosis of AbMR requires a kidney biopsy, and detection of complement C4d deposition in the allograft is one of the diagnostic criteria. Complement activation also generates several soluble fragments which could potentially provide non-invasive biomarkers of the process. Furthe ...
DOI:
10.1016/j.molimm.2019.12.011
PubMed:
31884386
PubMed Central:
PMC7192552

20. Complement Receptor 1 (CR1/CD35)-expressing retinal pigment epithelial cells as a potential therapy for age-related macular degeneration

Author:
Simmons, Ken T.; Mazzilli, John L.; Mueller-Ortiz, Stacey L.; Domozhirov, Aleksey Y.; Garcia, Charles A.; Zsigmond, Eva M.; Wetsel, Rick A.
Source:
Molecular immunology 2020 v.118 pp. 91-98
ISSN:
0161-5890
Subject:
complement,   etc   ; antibiotics; epithelial cells; erythrocytes; flow cytometry; inflammation; macular degeneration; proteins; retina; therapeutics;     Show all 10 Subjects
Abstract:
... The purpose of this study was to identify a membrane-bound complement inhibitor that could be overexpressed on retinal pigment epithelial cells (RPE) providing a potential therapy for age-related macular degeneration (AMD). This type of therapy may allow replacement of damaged RPE with cells that are able to limit complement activation in the retina. Complement Receptor 1 (CR1) is a membrane-bound ...
DOI:
10.1016/j.molimm.2019.11.007