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genotype-phenotype correlation, etc ; metabolites; metabolomics; phenotype; Show all 4 Subjects
Abstract:
... High-throughput (HTP) plant phenotyping approaches are developing rapidly and are already helping to bridge the genotype–phenotype gap. However, technologies should be developed beyond current physico-spectral evaluations to extend our analytical capacities to the subcellular level. Metabolites define and determine many key physiological and agronomic features in plants and an ability to integrate ...
genotype-phenotype correlation, etc ; computer software; data collection; genes; Show all 4 Subjects
Abstract:
... Multiplex assays of variant effect (MAVEs) are a family of methods that includes deep mutational scanning experiments on proteins and massively parallel reporter assays on gene regulatory sequences. Despite their increasing popularity, a general strategy for inferring quantitative models of genotype-phenotype maps from MAVE data is lacking. Here we introduce MAVE-NN, a neural-network-based Python ...
M. Fernanda Dreccer; Bethany Macdonald; Claire A. Farnsworth; M. Valeria Paccapelo; Mary Anne Awasi; Anthony G. Condon; Kerrie Forrest; Ian Lee Long; C. Lynne McIntyre
genetic correlation, etc ; cultivars; genotyping; germplasm; heritability; phenotype; wheat; Show all 7 Subjects
Abstract:
... KEY MESSAGE: Low-lodging high-yielding wheat germplasm and SNP-tagged novel alleles for lodging were identified in a process that involved selecting donors through functional phenotyping for underlying traits with a designed phenotypic screen, and a crossing strategy involving multiple-donor × elite populations. Lodging is a barrier to achieving high yield in wheat. As part of a study investigatin ...
genetic correlation, etc ; anthropology; data collection; humans; pleiotropy; statistical analysis; teeth; variance; Arizona; Show all 9 Subjects
Abstract:
... This study aims to expand our understanding of the genetic architecture of crown morphology in the human diphyodont dentition. Here, we present bivariate genetic correlation estimates for deciduous and permanent molar traits and evaluate the patterns of pleiotropy within (e.g., m1–m2) and between (e.g., m2–M1) dentitions. Morphology was observed and scored from dental models representing participa ...
Eva Clemente; Marta Martinez-Moro; Duong N Trinh; Mahmoud G. Soliman; Daniel I R Spencer; Richard A Gardner; Maximilianos Kotsias; Ana Sánchez Iglesias; Sergio Moya; Marco P Monopoli
fluorescence correlation spectroscopy, etc ; blood plasma; citrates; lectins; macrophages; nanogold; polysaccharides; protein corona; proteomics; Show all 9 Subjects
Abstract:
... Following blood administration, the pristine surface of nanoparticles (NPs) associates with biomolecules from the surrounding environment forming the so-called “biomolecular corona”. It is well accepted that the biomolecular corona dramatically affects the NP fate in the biological medium while the pristine surface is no longer available for binding. Recent studies have shown that the glycans asso ...
genetic correlation, etc ; Larimichthys polyactis; aquaculture; body length; body weight; genetic improvement; genetic variation; heritability; phenotype; Show all 9 Subjects
Abstract:
... Growth is an economically important trait in aquaculture. For the genetic improvement of growth traits in Larimichthys polyactis, a relatively new aquaculture species with great potential in large-scale farming, a genetic evaluation of these traits is necessary. In the present study, 34 families of L. polyactis were used to estimate genetic parameters for body weight, total length, and body length ...
... Using a variety of genetic resources, the aim of this study is to see how genetic background affects egg traits in chickens. Three different chicken genotypes (a commercial Brown layer, BOR; 2 Japanese indigenous breeds, NGY and YKD) were investigated effects on genotype in 10 external and internal egg quality traits along with 20 yolk and albumen free amino acid traits. Significant effects on gen ...
genotype-phenotype correlation, etc ; females; genes; genotyping; heterozygosity; homozygosity; meta-analysis; pregnancy; protocols; risk; systematic review; Show all 11 Subjects
Abstract:
... Recurrent pregnancy loss (RPL) is defined as the loss of two or more pregnancies, affecting approximately 1 to 3% of women worldwide. Scientific data highlight a possible correlation between thrombophilic genetic variants and RPL. H1299R variant in the factor V gene would lead to an increased thrombotic risk associated with frequent miscarriages. However, the data are often conflicting, making thi ...
genetic correlation; phenotypic correlation, etc ; Rhode Island Red; genetic relationships; genetic selection; heritability; models; temperament; Show all 8 Subjects
Abstract:
... BACKGROUND: As cage-free production systems become increasingly popular, behavioral traits such as nesting behavior and temperament have become more important. The objective of this study was to estimate heritabilities for frequency of perching and proportion of floor eggs and their genetic correlation in two Rhode Island Red lines. RESULTS: The percent of hens observed perching tended to increase ...
... Background: Poirier–Bienvenu Neurodevelopmental Syndrome (POBINDS) is a rare disease linked to mutations of the CSNK2B gene, which encodes for a subunit of caseinkinase CK2 involved in neuronal growth and synaptic transmission. Its main features include early-onset epilepsy and intellectual disability. Despite the lack of cases described, it appears that POBINDS could manifest with a wide range of ...
... Muscle fibre characteristics (MFCs) are related to lean meat production and meat quality. We newly estimated the heritability and genetic correlation of MFCs and meat quality in biopsied and post-mortem meat samples of 595 Jeju black pigs (JBPs). The cross-sectional area (CSA) (Type I: 0.76 and Type IIA: 0.89), % MF area (MFA) (Type I: 0.82), and % MF number (MFN) between the biopsied and post-mor ...
genetic correlation; phenotypic correlation, etc ; Holstein; cows; data collection; genomics; genotype; lactation; models; pedigree; phenotype; sires; temperament; Show all 13 Subjects
Abstract:
... Heritabilities of workability (WT) traits—milking speed (MS) and temperament (MT)—as well as genetic and phenotypic correlations between these traits in the population of Polish Holstein-Friesian (PHF) cows were estimated. The estimation of genetic parameters was performed twice: first with the use of pedigree data; and second with the use of pedigree and genomic data. Phenotypic data from routine ...
correlation, etc ; economics; logit analysis; researchers; Show all 4 Subjects
Abstract:
... In their discussion of stochastic complementarity, Manzini et al. (2018) show that the intuitively appealing correlation criterion does not—in general—satisfy the axiom of monotonicity: products classified as complements can turn into substitutes following an increase in their joint purchases. In this note, we show that, however, by restricting attention to mixed logit models along the lines of Ge ...
genetic correlation, etc ; casein; evolution; genomics; meta-analysis; milk; nitrogen; prediction; quantitative traits; urea nitrogen; Australia; New Zealand; Show all 12 Subjects
Abstract:
... BACKGROUND: Urinary nitrogen leakage is an environmental concern in dairy cattle. Selection for reduced urinary nitrogen leakage may be done using indicator traits such as milk urea nitrogen (MUN). The result of a previous study indicated that the genetic correlation between MUN in Australia (AUS) and MUN in New Zealand (NZL) was only low to moderate (between 0.14 and 0.58). In this context, an al ...
genetic correlation, etc ; Oreochromis niloticus; feed conversion; feed intake; fish; fish consumption; heritability; juveniles; video recording; weight gain; Show all 10 Subjects
Abstract:
... Feed conversion ratio (FCR) is an important trait to target in breeding programs in order to improve fish farming sustainability and increase environmental efficiency. Due to the complexity of accurately measuring the individual feed consumption of fish, developing a selective breeding programme to improve FCR is a challenge. Using video-recordings of several consecutive meals in tilapia groups, w ...
... Familial Mediterranean Fever (FMF, OMIM ID: 249100) is the most common autoinflammatory, autosomal recessive disease caused by mutations in the MEFV gene. It is widespread in the Mediterranean, primarily among Turkish, Armenian, Arab and Jewish. This study aims to examine genotype distributions of common MEFV variants in the Turkish population using targeted NGS and to evaluate all rare mutations. ...
... The BG line was originated from the cross between 2 Chinese indigenous breeds, Dongxiang blue eggshell, and Jiangshan black-bone, and has been bred to combine dark heavy black-bone body and high production of blue-shell eggs, into single dual-purpose line. Full-pedigree hens from 2 generations, G4 (n = 441) and G5 (n = 464), were reared in the same single-cage laying facility in 2019–2020 and 2020 ...
genotype-phenotype correlation, etc ; genome; surveys; uncertainty; Show all 4 Subjects
Abstract:
... The reconstruction and analysis of genome-scale metabolic models constitutes a powerful systems biology approach, with applications ranging from basic understanding of genotype-phenotype mapping to solving biomedical and environmental problems. However, the biological insight obtained from these models is limited by multiple heterogeneous sources of uncertainty, which are often difficult to quanti ...
genetic correlation, etc ; animal models; average daily gain; body weight; climate change; farms; feed intake; heat stress; heritability; phenotype; piglets; Show all 11 Subjects
Abstract:
... Due to the diversification of farming systems and climate change, farm animals are exposed to environmental disturbances to which they respond differently depending on their robustness. Disturbances such as heat stress or sanitary challenges (not always recorded, especially when they are of short duration and low intensity) have a transitory impact on animals, resulting in changes in phenotypes of ...
phenotypic correlation, etc ; Populus trichocarpa; biocompatible materials; biofuels; forests; genotype-environment interaction; phenology; phenotypic plasticity; research; woody biomass; Latvia; Sweden; Show all 12 Subjects
Abstract:
... Transition towards a bio-based society requires large amounts of woody biomass to be converted into biofuels and biomaterials. Populus species are good candidates for growth in short rotations, but there is a lack of climate-adapted plant material suitable for growth at the high latitudes of the Nordic–Baltic region. Here we studied the growth and phenology traits in 63 Populus trichocarpa clones ...