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1. Comparative Analysis of Embryonic Inversion in Algae of the Genus Volvox (Volvocales, Chlorophyta)

Author:
Desnitskiy, A.G.
Source:
Russian journal of developmental biology 2018 v.49 no.3 pp. 129-133
ISSN:
1062-3604
Subject:
cytoplasm,   etc   ; Volvox; algae; flagellum; gastrulation;     Show all 5 Subjects
Abstract:
... Recent literary data on inversion (turning inside out) in the embryos of flagellated algae of the genus Volvox are critically analyzed. In this process, active changes in the shape of embryonic cells and the displacement of intercellular cytoplasmic bridges play an important role. After inversion, the flagella appear on the outer side of the young colony and provide its motility. Within the genus ...
DOI:
10.1134/S1062360418030025

2. Inflammasomes and Leishmania: in good times or bad, in sickness or in health

Author:
Zamboni, Dario S; Sacks, David L
Source:
Current opinion in microbiology 2019 v.52 pp. 70-76
ISSN:
1369-5274
Subject:
cytoplasm,   etc   ; Leishmania; inflammasomes; leishmaniasis; macrophages; parasites; pathogens; tissues;     Show all 8 Subjects
Abstract:
... The inflammasomes are multi-molecular platforms that are activated in host cell cytoplasm when the innate immune cells are infected with pathogens or exposed to damage signals. Many independent groups reported that Leishmania infection trigger activation of the NLRP3 inflammasome in macrophages for restriction of intracellular parasite replication. Accordingly, Leishmania can dampen NLRP3 activati ...
DOI:
10.1016/j.mib.2019.05.005

3. Combined apoptotic effects of peptide and miRNA in a peptide/miRNA nanocomplex

Author:
Kim, Hyungjin; Kitamatsu, Mizuki; Ohtsuki, Takashi
Source:
Journal of bioscience and bioengineering 2019 v.128 no.1 pp. 110-116
ISSN:
1389-1723
Subject:
cytoplasm,   etc   ; apoptosis; bioactive properties; microRNA; photoirradiation; small interfering RNA;     Show all 6 Subjects
Abstract:
... The present study investigated combined biological effects of peptide and miRNA in a peptide/miRNA nanocomplex. We utilized TatBim peptide as a cell-penetrating peptide-based RNA carrier with apoptotic activity. miRNA with apoptotic activity (miR-34a) was used for complex formation to investigate the additional effects of the combination with TatBim peptide. TatBim peptide and the miRNA formed nan ...
DOI:
10.1016/j.jbiosc.2019.01.003

4. Nuclear Pore Membrane Proteins Self-Assemble into Nanopores

Author:
Panatala, Radhakrishnan; Barbato, Suncica; Kozai, Toshiya; Luo, Jinghui; Kapinos, Larisa E.; Lim, Roderick Y. H.
Source:
Biochemistry 2019 v.58 no.6 pp. 484-488
ISSN:
1520-4995
Subject:
cytoplasm,   etc   ; lipid bilayers; membrane proteins; nanopores; nuclear pore;     Show all 5 Subjects
Abstract:
... Large multiprotein nanopores remain difficult to reconstitute in vitro, such as, for instance, the nuclear pore complex (NPC) that regulates macromolecular transport between the nucleus and cytoplasm in cells. Here, we report that two NPC pore membrane proteins self-assemble into ∼20 nm diameter nanopores following in vitro reconstitution into lipid bilayers. Pore formation follows from the assemb ...
DOI:
10.1021/acs.biochem.8b01179

5. Functional Actin Networks under Construction: The Cooperative Action of Actin Nucleation and Elongation Factors

Author:
Siton-Mendelson, Orit; Bernheim-Groswasser, Anne
Source:
Trends in biochemical sciences 2017 v.42 no.6 pp. 414-430
ISSN:
0968-0004
Subject:
cytoplasm,   etc   ; actin; models; polymerization;     Show all 4 Subjects
Abstract:
... Cells require actin nucleation factors to catalyze the formation of actin networks and elongation factors to control the rate and extent of actin polymerization. Earlier models suggested that the different factors assemble actin networks independently. However, recent evidence indicates that the assembly of most cellular networks involves multiple nucleation and elongation factors that work in con ...
DOI:
10.1016/j.tibs.2017.03.002

6. Epigenetic Control of Autophagy: Nuclear Events Gain More Attention

Author:
Baek, Sung Hee; Kim, Keun Il
Source:
Molecular cell 2017 v.65 no.5 pp. 781-785
ISSN:
1097-2765
Subject:
cytoplasm,   etc   ; autophagy; epigenetics;     Show all 3 Subjects
Abstract:
... Autophagy is an evolutionarily conserved catabolic process. Although the components of autophagy in cytoplasm have been well-studied, the molecular basis for the epigenetic regulation of autophagy is poorly understood. It is becoming more important to propose a “whole-cell view” of autophagy embracing both cytoplasmic and nuclear events. Thus, it is great timing to summarize current status and dis ...
DOI:
10.1016/j.molcel.2016.12.027

7. Transcriptional effects of actin-binding compounds: the cytoplasm sets the tone

Author:
Gegenfurtner, Florian A.; Zisis, Themistoklis; Al Danaf, Nader; Schrimpf, Waldemar; Kliesmete, Zane; Ziegenhain, Christoph; Enard, Wolfgang; Kazmaier, Uli; Lamb, Don C.; Vollmar, Angelika M.; Zahler, Stefan
Source:
Cellular and molecular life sciences 2018 v.75 no.24 pp. 4539-4555
ISSN:
1420-682X
Subject:
cytoplasm,   etc   ; actin; gene expression; polymerization; transcription (genetics);     Show all 5 Subjects
Abstract:
... Actin has emerged as a versatile regulator of gene transcription. Cytoplasmatic actin regulates mechanosensitive-signaling pathways such as MRTF–SRF and Hippo-YAP/TAZ. In the nucleus, both polymerized and monomeric actin directly interfere with transcription-associated molecular machineries. Natural actin-binding compounds are frequently used tools to study actin-related processes in cell biology. ...
DOI:
10.1007/s00018-018-2919-4

8. Programmed Secretion Arrest and Receptor-Triggered Toxin Export during Antibacterial Contact-Dependent Growth Inhibition

Author:
Ruhe, Zachary C.; Subramanian, Poorna; Song, Kiho; Nguyen, Josephine Y.; Stevens, Taylor A.; Low, David A.; Jensen, Grant J.; Hayes, Christopher S.
Source:
Cell 2018 v.175 no.4 pp. 921-933.e14
ISSN:
0092-8674
Subject:
cytoplasm,   etc   ; bacteria; growth retardation; secretion; toxins;     Show all 5 Subjects
Abstract:
... Contact-dependent growth inhibition (CDI) entails receptor-mediated delivery of CdiA-derived toxins into Gram-negative target bacteria. Using electron cryotomography, we show that each CdiA effector protein forms a filament extending ∼33 nm from the cell surface. Remarkably, the extracellular filament represents only the N-terminal half of the effector. A programmed secretion arrest sequesters the ...
DOI:
10.1016/j.cell.2018.10.033

9. Cultivation Conditions Can Cause a Shift from Mutualistic to Parasitic Behavior in the Symbiosis Between Paramecium and Its Bacterial Symbiont Caedibacter taeniospiralis

Author:
Schu, Maria Giovanna; Schrallhammer, Martina
Source:
Current microbiology 2018 v.75 no.8 pp. 1099-1102
ISSN:
0343-8651
Subject:
cytoplasm,   etc   ; Paramecium tetraurelia; bacteria; mutualism; parasites; symbionts;     Show all 6 Subjects
Abstract:
... Caedibacter taeniospiralis is an obligate bacterial symbiont living in the cytoplasm of the ciliate Paramecium tetraurelia. Different studies analyzing the effect of this symbiont on its host’s growth and maximal cell density arrive at contradicting conclusions, labeling it as either a parasite or a mutualist. We address the question whether extrinsic factors such as medium and food organism are r ...
DOI:
10.1007/s00284-018-1493-1

10. The nuclear pore complex: a strategic platform for regulating cell signaling

Author:
Gu, Yangnan
Source:
Thenew phytologist 2018 v.219 no.1 pp. 25-30
ISSN:
0028-646X
Subject:
cytoplasm,   etc   ; eukaryotic cells; nuclear pore; nucleocytoplasmic transport;     Show all 4 Subjects
Abstract:
... Contents Summary 25 I Introduction 25 II. Structural organization of the NPC 26 III. The role of NPCs in immune signaling 26 IV. The role of NPCs in hormone signaling 28 V. Conclusions 29 Acknowledgements 29 References 29 SUMMARY: Nuclear pore complexes (NPCs) are fundamental components of the eukaryotic cell. They perforate the nuclear envelope and serve as highly selective transport gates that e ...
DOI:
10.1111/nph.14756

11. Membrane Protein Dislocation by the Rhomboid Pseudoprotease Dfm1: No Pore Needed?

Author:
Avci, Dönem; Lemberg, Marius K.
Source:
Molecular cell 2018 v.69 pp. 161-162
ISSN:
1097-2765
Subject:
cytoplasm,   etc   ; membrane proteins; proteasome endopeptidase complex;     Show all 3 Subjects
Abstract:
... Defective ER-resident membrane proteins need to be ejected into the cytoplasm in order to be degraded by the proteasome, but the exact mechanism remains unclear. In this issue of Molecular Cell, Neal et al. (2018) reveal that the rhomboid pseudoprotease Dfm1 defines the central ERAD component for membrane protein dislocation. ...
DOI:
10.1016/j.molcel.2017.12.031

12. Endowing a triarylboron compound showing ACQ with AIE characteristics by transforming its emissive TICT state to be dark

Author:
Liu, Jun; Zhang, Chenghua; Dong, Jun; Zhu, Jiang; Shen, Chengyi; Yang, Guoqiang; Zhang, Xiaoming
Source:
RSC advances 2017 v.7 no.24 pp. 14511-14515
ISSN:
2046-2069
Subject:
cytoplasm,   etc   ; fluorescent dyes; image analysis;     Show all 3 Subjects
Abstract:
... A triarylboron-based AIE fluorophore, TAB-AIE-FL, was designed and synthesized by introducing an electron acceptor to boost charge separation, transforming its TICT state from bright emission to dark. We further introduced it into NIH/3T3 cells using nanogel as a carrier for imaging the intracellular environments of cytoplasm and nucleus. ...
DOI:
10.1039/c7ra00426e

13. Plant lamin-like proteins mediate chromatin tethering at the nuclear periphery

Author:
Hu, Bo; Wang, Nan; Bi, Xiuli; Karaaslan, Ezgi Süheyla; Weber, Anna-Lena; Zhu, Wangsheng; Berendzen, Kenneth Wayne; Liu, Chang
Source:
Genome biology 2019 v.20 no.1 pp. 87
ISSN:
1474-760X
Subject:
cytoplasm,   etc   ; Arabidopsis thaliana; DNA; DNA methylation; animals; chromosome painting; heterochromatin; mutants; nuclear membrane; plants (botany);     Show all 10 Subjects
Abstract:
... BACKGROUND: The nuclear envelope not only serves as a physical barrier separating nuclear content from the cytoplasm but also plays critical roles in modulating the three-dimensional organization of genomic DNA. For both plants and animals, the nuclear periphery is a functional compartment enriched with heterochromatin. To date, how plants manage to selectively tether chromatin at the nuclear peri ...
DOI:
10.1186/s13059-019-1694-3

14. Effect of male sterile and fertile cytoplasm on nuclear DNA methylation in hybrid rice

Author:
Ali, Asif; Li, Yun; Chen, Hui; Xu, Peizhou; Zhang, Hongyu; Chen, Xiaoqiong; Yongxiang, Liao; Fu, Shaohong; Wu, Tingkai; Iqbal, Muhammad Zafar; Farooq, Muhammad Umer; Wu, Xianjun
Source:
Acta physiologiae plantarum 2019 v.41 no.6 pp. 81
ISSN:
0137-5881
Subject:
cytoplasm,   etc   ; DNA methylation; cytoplasmic male sterility; heterosis; hybrids; nuclear genome; parents; rice;     Show all 8 Subjects
Abstract:
... Nucleus-controlled fertility restoration and cytoplasmic male sterility are important mechanisms to exploit heterosis. However, the effect of DNA methylation on cytoplasmic-nuclear interaction is not well understood yet. The current study used a methylation-sensitive amplified polymorphism to characterize polymorphism in nuclear DNA methylation among cytoplasmic male sterile line (D62A), correspon ...
DOI:
10.1007/s11738-019-2874-1

15. Structural insights into amyloid structures of the C-terminal region of nucleophosmin 1 in type A mutation of acute myeloid leukemia

Author:
Di Natale, Concetta; La Manna, Sara; Malfitano, Anna Maria; Di Somma, Sarah; Florio, Daniele; Scognamiglio, Pasqualina Liana; Novellino, Ettore; Netti, Paolo Antonio; Marasco, Daniela
Source:
Biochimica et biophysica acta 2019 v.1867 no.6 pp. 637-644
ISSN:
1570-9639
Subject:
cytoplasm,   etc   ; amyloid; genes; hematopoietic stem cells; mutation; myeloid leukemia; polypeptides; therapeutics; toxicity testing;     Show all 9 Subjects
Abstract:
... Acute myeloid leukemia (AML) is a clinically and a molecularly heterogeneous disease characterized by the accumulation of undifferentiated and uncontrolled proliferation of hematopoietic progenitor cells. The sub-group named “AML with gene mutations” includes mutations in nucleophosmin (NPM1) assumed as a distinct leukemic entity. NPM1 is an abundant multifunctional protein belonging to the nucleo ...
DOI:
10.1016/j.bbapap.2019.01.010

16. Facile, rapid one-pot synthesis of multifunctional gold nanoclusters for cell imaging, hydrogen sulfide detection and pH sensing

Author:
Gao, Pengfei; Li, Min; Zhang, Yan; Dong, Chuan; Zhang, Guomei; Shi, Lihong; Li, Gao; Yuan, Mingjian; Shuang, Shaomin
Source:
Talanta 2019 v.197 pp. 1-11
ISSN:
0039-9140
Subject:
cytoplasm,   etc   ; ambient temperature; biocompatibility; fluorescence; hydrogen sulfide; image analysis; monitoring; nanogold; pH; synthesis; toxicity; water solubility;     Show all 12 Subjects
Abstract:
... In this study, we have developed a facile, rapid one-pot strategy for synthesis of orange fluorescent gold nanoclusters (MBISA–AuNCs) at room temperature by using 2-Mercapto-5-benzimidazolesulfonic acid (MBISA) as both reducing and protecting reagent. The prepared AuNCs exhibited prominent advantages including high fluorescent quantum yield, good water solubility, excellent biocompatibility and lo ...
DOI:
10.1016/j.talanta.2018.12.078

17. Pyruvate Responsiveness Based on α-Oxohydrazone Formation for Intracellular siRNA Release from Polyion Complex-Based Carriers

Author:
Takemoto, Hiroyasu; Wang, Chih-Ling; Nomoto, Takahiro; Matsui, Makoto; Tomoda, Keishiro; Nishiyama, Nobuhiro
Source:
Biomacromolecules 2019 v.20 no.6 pp. 2305-2314
ISSN:
1526-4602
Subject:
cytoplasm,   etc   ; electrostatic interactions; gene silencing; hydrazides; moieties; polymers; pyruvic acid; small interfering RNA;     Show all 8 Subjects
Abstract:
... Selective release of small interfering RNA (siRNA) payloads in response to intracellular substances is a prerequisite for the smart design of siRNA carriers. In this context, we developed a molecular program that allows reactivity with pyruvate for siRNA release in the cell on the basis of polyionic-complex- (PIC-) based siRNA carriers. Hydrazide can react with the α-keto acid structure of anionic ...
DOI:
10.1021/acs.biomac.9b00261

18. PBS3 Protects EDS1 from Proteasome-Mediated Degradation in Plant Immunity

Author:
Chang, Ming; Zhao, Jinping; Chen, Huan; Li, Guangyong; Chen, Jian; Li, Min; Palmer, Ian A.; Song, Junqi; Alfano, James R.; Liu, Fengquan; Fu, Zheng Qing
Source:
Molecular plant 2019 v.12 no.5 pp. 678-688
ISSN:
1674-2052
Subject:
cytoplasm,   etc   ; immunity; proteasome endopeptidase complex; receptors; salicylic acid; ubiquitin-protein ligase; ubiquitination;     Show all 7 Subjects
Abstract:
... Plant immunity is controlled by both positive regulators such as PBS3 and EDS1 and negative regulators such as NPR3 and NPR4. However, the relationships among these important immune regulators remain elusive. In this study, we found that PBS3 interacts with EDS1 in both the cytoplasm and the nucleus, and is required for EDS1 protein accumulation. NPR3 and NPR4, which function as salicylic acid rec ...
DOI:
10.1016/j.molp.2019.01.023

19. Role for tyrosine phosphorylation of SUV39H1 histone methyltransferase in enhanced trimethylation of histone H3K9 via neuregulin-1/ErbB4 nuclear signaling

Author:
Nakajo, Haruna; Ishibashi, Kenichi; Aoyama, Kazumasa; Kubota, Sho; Hasegawa, Hitomi; Yamaguchi, Noritaka; Yamaguchi, Naoto
Source:
Biochemical and biophysical research communications 2019 v.511 no.4 pp. 765-771
ISSN:
0006-291X
Subject:
cytoplasm,   etc   ; Diptera; chromatin; epidermal growth factor receptors; histones; humans; ligands; lysine; methyltransferases; mice; mutants; phosphorylation; tyrosine;     Show all 13 Subjects
Abstract:
... Protein-tyrosine kinases transmit signals by phosphorylating their substrates in diverse cellular events. The receptor-type tyrosine kinase ErbB4, a member of the epidermal growth factor receptor subfamily, is activated and proteolytically cleaved upon ligand stimulation, and the cleaved ErbB4 intracellular domain (4ICD) is released into the cytoplasm and the nucleus. We previously showed that gen ...
DOI:
10.1016/j.bbrc.2019.02.130

20. Exportin-1 is required for the maintenance of the planarian epidermal lineage

Author:
Tian, Qingnan; Zhao, Guixia; Sun, Yujia; Yuan, Dandan; Guo, Qi; Zhang, Yizhe; Liu, Jiaqian; Zhang, Shoutao
Source:
International journal of biological macromolecules 2019 v.126 pp. 1050-1055
ISSN:
0141-8130
Subject:
cytoplasm,   etc   ; Platyhelminthes; RNA interference; adult stem cells; cell division; nucleocytoplasmic transport; phenotype; vimentin;     Show all 8 Subjects
Abstract:
... Nucleocytoplasmic transport is essential for normal cellular function that mediates cargo transport from the cytoplasm to the nucleus. However, the mechanisms of nucleocytoplasmic transport that integrate stem cell development remain largely unknown. Since it has a large population of stem cells, the planarian flatworm is an ideal system for the study of adult stem cell lineage development in vivo ...
DOI:
10.1016/j.ijbiomac.2019.01.014