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1. To the edge of cell death and back

Author:
Gong, Yi‐Nan; Crawford, Jeremy Chase; Heckmann, Bradlee L.; Green, Douglas R.
Source:
TheFEBS journal 2019 v.286 no.3 pp. 430-440
ISSN:
1742-464X
Subject:
death; programmed cell death,   etc   ; homeostasis; therapeutics;     Show all 4 Subjects
Abstract:
... Programmed cell death plays a central role in maintaining homeostasis. Various studies have demonstrated that programmed cell death is not a one‐way street; cells can survive even when the core cell death processes are underway. Cell death initiation, prevention, and recovery function in a coordinated fashion to establish and maintain a homeostatic environment. In this review, we discuss how dying ...
DOI:
10.1111/febs.14714

2. Suicide identification during on-site inspection. Proposal and application of an interpretative method for death scene investigation

Author:
Visentin, Sindi; Massaro, Luca; Viel, Guido; Cecchetto, Giovanni; Montisci, Massimo
Source:
Forensic science international 2019 v.297 pp. 148-155
ISSN:
0379-0738
Subject:
death,   etc   ; behavior disorders; risk; suicide;     Show all 4 Subjects
Abstract:
... Death scene investigation (DSI) is critically important for the identification of the manner of death. The present study aims to present a scoring system for the correct framing of a case as a suicide starting from the DSI and its preliminary application. The method is based on five items: (1) statistical frequency of the method adopted; (2) victim’s history of mental illness; (3) circumstantial d ...
DOI:
10.1016/j.forsciint.2019.01.029

3. Don’t Name Them, Don’t Show Them, But Report Everything Else: A Pragmatic Proposal for Denying Mass Killers the Attention They Seek and Deterring Future Offenders

Author:
Lankford, Adam; Madfis, Eric
ISSN:
1552-3381
Subject:
death,   etc   ; crime;     Show all 2 Subject
Abstract:
... Prior research has shown that many mass shooters have explicitly admitted they want fame and have directly reached out to media organizations to get it. These fame-seeking offenders are particularly dangerous because they kill and wound significantly more victims than other active shooters, they often compete for attention by attempting to maximize victim fatalities, and they can inspire contagion ...
DOI:
10.1177/0002764217730854

4. Relieving the “Sudden Death” of Li–O₂ Batteries by Grafting an Antifouling Film on Cathode Surfaces

Author:
Guo, Limin; Wang, Jiawei; Gu, Feng; Ma, Lipo; Zhao, Zhiwei; Liu, Jianjun; Peng, Zhangquan
Source:
ACS applied materials & interfaces 2019 v.11 no.16 pp. 14753-14758
ISSN:
1944-8252
Subject:
death,   etc   ; adsorption; batteries; cathodes; electrolytes; solvents; spectroscopy;     Show all 7 Subjects
Abstract:
... The “sudden-death” phenomenon has been frequently encountered during discharging of Li–O₂ batteries and has been ascribed to the growth of a blocking film of Li₂O₂ on the cathode surface. Recent fundamental study revealed that this dilemma could be addressed by discharging Li₂O₂ in the electrolyte solution rather than on the cathode surface. However, even for Li–O₂ batteries operated under the con ...
DOI:
10.1021/acsami.8b22643

5. Life and the five biological laws. Lessons for global change models and sustainability

Author:
Penuelas, Josep; Baldocchi, Dennis
Source:
Ecological complexity 2019 v.38 pp. 11-14
ISSN:
1476-945X
Subject:
death,   etc   ; energy; global change; learning; models;     Show all 5 Subjects
Abstract:
... Life on Earth is the result of a continuous accumulation of information by combination and innovation using endo- (inside the organism) and exosomatic (outside the organism) energy. Sustenance occurs through cycles of life and death. We here define five life laws for these vital processes. These processes cannot exceed natural limits of size and rates because they are constrained by space, matter ...
DOI:
10.1016/j.ecocom.2019.02.001

6. ADAR1: A New Target for Immuno-oncology Therapy

Author:
Bhate, Amruta; Sun, Tao; Li, Jin Billy
Source:
Molecular cell 2019 v.73 no.5 pp. 866-868
ISSN:
1097-2765
Subject:
cell death,   etc   ; RNA editing; immunotherapy; neoplasm cells;     Show all 4 Subjects
Abstract:
... Three recent studies by Ishizuka et al. (2019), Liu et al. (2019), and Gannon et al. (2018) show that deleting RNA editing enzyme ADAR1 could induce higher cell lethality and render tumor cells more vulnerable to immunotherapy, pinpointing ADAR1 as a new immuno-oncology target. ...
DOI:
10.1016/j.molcel.2019.02.021

7. Dissecting plant hormone signaling with synthetic molecules: perspective from the chemists

Author:
Hagihara, Shinya; Yamada, Ryotaro; Itami, Kenichiro; Torii, Keiko U
Source:
Current opinion in plant biology 2019 v.47 pp. 32-37
ISSN:
1369-5266
Subject:
death,   etc   ; abscisic acid; auxins; chemistry; chemists; strigolactones;     Show all 6 Subjects
Abstract:
... Synthetic molecules can be powerful tools to overcome the limitations of the biological approaches. Especially redundancy, lethality, and intractability of the target genes, which often hamper the progress of plant science, could be bypassed by elaborately designed small molecules. In this review, we discuss how synthetic chemistry can contribute to increasing our understanding of plant hormone si ...
DOI:
10.1016/j.pbi.2018.09.002

8. Efficacy of three-dimensional cinematic rendering computed tomography images in visualizing features related to age estimation in pelvic bones

Author:
Pattamapaspong, Nuttaya; Kanthawang, Thanat; Singsuwan, Phruksachat; Sansiri, Witsuta; Prasitwattanaseree, Sukon; Mahakkanukrauh, Pasuk
Source:
Forensic science international 2019 v.294 pp. 48-56
ISSN:
0379-0738
Subject:
death,   etc   ; computed tomography; forensic sciences; ilium;     Show all 4 Subjects
Abstract:
... Morphological changes on the surface of the pelvic bone can be used to estimate the age at death of a person. These features can be visualized using three dimensional computed tomography (3D CT) images. A newly introduced 3D CT technique, cinematic volume rendering, improves visualization of the surface of bones by integrating the effect of light on the images. The aim of this study is to evaluate ...
DOI:
10.1016/j.forsciint.2018.10.003

9. Development of an inexpensive rollover energy dissipation device to improve safety provided by ROPS

Author:
Latorre-Biel, Juan-Ignacio; Ballesteros, Tomás; Arana, Ignacio; Alfaro, José R.
Source:
Biosystems engineering 2019
ISSN:
1537-5110
Subject:
death,   etc   ; accidents; deformation; energy; models; tractors;     Show all 6 Subjects
Abstract:
... Tractor overturn is the most common cause fatal accidents in agriculture. Installing rollover protective structures (ROPS), in combination with the use of a safety seat belt, is the best way to avoid fatalities. A ROPS must be able to absorb the rollover energy without collapsing or suffering such a deformation that infringes the safety zone, where the tractor operator must remain. Therefore, any ...
DOI:
10.1016/j.biosystemseng.2019.02.004

10. Dynamics of Inter-Molecular Interactions Between Single Aβ42 Oligomeric and Aggregate Species by High-Speed Atomic Force Microscopy

Author:
Feng, Lei; Watanabe, Hiroki; Molino, Paul; Wallace, Gordon G.; Phung, Son L.; Uchihashi, Takayuki; Higgins, Michael J.
Source:
Journal of molecular biology 2019
ISSN:
0022-2836
Subject:
cell death; death,   etc   ; Alzheimer disease; amyloid; atomic force microscopy; energy; etiology; liquids; neurons; oligomerization; peptides; toxicity;     Show all 12 Subjects
Abstract:
... Within the amyloid hypothesis in Alzheimer's disease, current focus has shifted to earlier stages of amyloid beta (Aβ) peptide assembly, involving soluble oligomers and smaller aggregates, which are more toxic to cells compared to their morphological distinct fibril forms. Critical to the Aβ field is unlocking the molecular-level kinetic pathways of oligomerization, leading to the culprit subset o ...
DOI:
10.1016/j.jmb.2019.04.044

11. Die in pieces: How Drosophila sheds light on neurite degeneration and clearance

Author:
Sapar, Maria L.; Han, Chun
Source:
Journal of genetics and genomics 2019 v.46 no.4 pp. 187-199
ISSN:
1673-8527
Subject:
cell death; death,   etc   ; Drosophila melanogaster; models; neurites; neurodegenerative diseases; neurophysiology; phagocytes;     Show all 8 Subjects
Abstract:
... Dendrites and axons are delicate neuronal membrane extensions that undergo degeneration after physical injuries. In neurodegenerative diseases, they often degenerate prior to neuronal death. Understanding the mechanisms of neurite degeneration has been an intense focus of neurobiology research in the last two decades. As a result, many discoveries have been made in the molecular pathways that lead ...
DOI:
10.1016/j.jgg.2019.03.010

12. Using mRNA to investigate the effect of low-pressure ultraviolet disinfection on the viability of E. coli

Author:
Yang, Chao; Sun, Wenjun; Ao, Xiuwei
Source:
Frontiers of environmental science & engineering 2019 v.13 no.2 pp. 26
ISSN:
2095-2201
Subject:
death; programmed cell death,   etc   ; Escherichia coli; disinfection; genes; messenger RNA; ultraviolet radiation; viability;     Show all 8 Subjects
Abstract:
... The efficacy of ultraviolet (UV) disinfection has been analyzed and validated by numerous studies using culture-based methods, yet the discovery of the viable but nonculturable state necessitates the investigation of UV disinfection based on viability parameters. Paired regulators of the SOS response system, recA-lexA, and the programmed cell death system, mazEF, in Escherichia coli were chosen as ...
DOI:
10.1007/s11783-019-1111-x

13. B23/Nucleophosmin promotes reconstitution of synaptic path in hippocampus after injury

Author:
Yun, Taegwan; Ko, Hyo Rim; Ahn, Jaeyoung; Jin, Eun-Ju; Jo, Jung Min; Kwon, Il-Sun; Cho, Sung-Woo; Chang, Yun Sil; Park, Won Soon; Ahn, Jee-Yin
Source:
Biochemical and biophysical research communications 2019 v.508 no.4 pp. 1082-1087
ISSN:
0006-291X
Subject:
cell death; death,   etc   ; axons; cell cycle; cell proliferation; cell viability; hippocampus; synapse;     Show all 8 Subjects
Abstract:
... B23, also known as nucleophosmin (NPM), is multifunctional protein directly implicated in cell proliferation, cell cycle progression, and cell survival. In the current study, in addition to confirming its anti-apoptotic function in neuronal survival, we demonstrated that the spatial-temporal expression profile of B23 during development of hippocampal neurons is high in the embryonic stage, down-re ...
DOI:
10.1016/j.bbrc.2018.12.036

14. Mechanism for Synthetic Lethality in BRCA-Deficient Cancers: No Longer Lagging Behind

Author:
van Wietmarschen, Niek; Nussenzweig, Andre
Source:
Molecular cell 2018 v.71 no.6 pp. 877-878
ISSN:
1097-2765
Subject:
death,   etc   ; genome; neoplasms;     Show all 3 Subjects
Abstract:
... Two recent studies implicate PARP as sensors of incompletely processed Okazaki fragments, changing our view about how single-strand breaks arise in unperturbed cells. Unligated Okazaki fragments may trigger homologous recombination-mediated repair and underpin genome instability in BRCA1/BRCA2-deficient cancers. ...
DOI:
10.1016/j.molcel.2018.08.045

15. Rapid cardiac compression: An effective method of avian euthanasia

Author:
Engilis, Andrew; Engilis, Irene E.; Paul-Murphy, Joanne
Source:
TheCondor 2018 v.120 no.3 pp. 617-621
ISSN:
1938-5129
Subject:
death,   etc   ; birds; euthanasia;     Show all 3 Subjects
Abstract:
... Proper methods for euthanasia are critical for research with birds. Training in these methods is generally required by institutional animal care and use committees for any research that involves handling of birds, even if the intent is for birds to be released into the wild. Rapid cardiac compression (RCC) remains a preferred method for quick euthanasia in field settings but has not been described ...
DOI:
10.1650/CONDOR-18-35.1

16. The obesity supine death syndrome (OSDS)

Author:
Lemyze, M.; Guiot, A.; Mallat, J.; Thevenin, D.
Source:
Obesity reviews 2018 v.19 no.4 pp. 550-556
ISSN:
1467-7881
Subject:
death,   etc   ; obesity; pathophysiology; patients;     Show all 4 Subjects
Abstract:
... The obesity supine death syndrome refers to a catastrophic cascade of cardiorespiratory complications resulting from the supine positioning of a morbidly obese subject which can ultimately lead to death. It was first described in 1977 in two massively obese patients who were forced to lie down for medical procedures. But surprisingly, despite the current worldwide epidemic of obesity, very few cas ...
DOI:
10.1111/obr.12655

17. A fluvoxamine-related fatality: Case report with postmortem concentrations

Author:
Otter, Jenna; McIntyre, Iain M.; Morhaime, Jacquelyn; Cantrell, Lee
Source:
Forensic science international 2019 v.300 pp. e31
ISSN:
0379-0738
Subject:
death,   etc   ; blood; case studies; hypotension; liver; overdose; seizures; serotonin; toxicity;     Show all 9 Subjects
Abstract:
... Fluvoxamine is a selective serotonin reuptake inhibitor that has been considered relatively safe in overdose. At therapeutic and supratherapeutic concentrations, fluvoxamine affects cardiac conduction, prolongs QTc interval, causes hypotension, obtundation, and can increase propensity for seizures. A man in his 60s was found dead at his home with a postmortem fluvoxamine peripheral blood concentra ...
DOI:
10.1016/j.forsciint.2019.02.047

18. Ferroptosis: Yet Another Way to Die

Author:
Kazan, Kemal; Kalaipandian, Sundaravelpandian
Source:
Trends in plant science 2019 v.24 no.6 pp. 479-481
ISSN:
1360-1385
Subject:
cell death,   etc   ; cells; iron; plants (botany); reactive oxygen species;     Show all 5 Subjects
Abstract:
... Cell death is one of the most fundamental biological processes operating in multicellular organisms. Recent research highlighted here [Distéfano et al. (J. Cell Biol. 2017:216;463–476) and Dangol et al. (Plant Cell 2019:31;189–209)] revealed an iron- and ROS-dependent cell death phenomenon called ferroptosis in plants. Features distinguishing ferroptosis from other cell death events and how ferrop ...
DOI:
10.1016/j.tplants.2019.03.005

19. Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage

Author:
Uderhardt, Stefan; Martins, Andrew J.; Tsang, John S.; Lämmermann, Tim; Germain, Ronald N.
Source:
Cell 2019 v.177 no.3 pp. 541-555.e17
ISSN:
0092-8674
Subject:
cell death,   etc   ; chemoattractants; homeostasis; image analysis; macrophages; microscopy; neutrophils; tissues;     Show all 8 Subjects
Abstract:
... Neutrophils are attracted to and generate dense swarms at sites of cell damage in diverse tissues, often extending the local disruption of organ architecture produced by the initial insult. Whether the inflammatory damage resulting from such neutrophil accumulation is an inescapable consequence of parenchymal cell death has not been explored. Using a combination of dynamic intravital imaging and c ...
DOI:
10.1016/j.cell.2019.02.028

20. The relevance of pyroptosis in the pathogenesis of liver diseases

Author:
Guo, Huiting; Xie, Mingjie; Zhou, Cheng; Zheng, Min
Source:
Life sciences 2019 v.223 pp. 69-73
ISSN:
0024-3205
Subject:
programmed cell death,   etc   ; cytokines; hosts; liver diseases; pathogenesis;     Show all 5 Subjects
Abstract:
... Pyroptosis is a novel programmed cell death form which is distinct from other types of cell death. As an inherently inflammatory process, it plays a vital role in cellular lysis and release of pro-inflammatory cytokines when hosts defend against infections. Recent studies have reported that pyroptosis was involved in liver diseases and had important functions in the progress and development of liv ...
DOI:
10.1016/j.lfs.2019.02.060