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- den Dunnen, Jeroen, et al. Show all 3 Authors
- Cellular and molecular life sciences 2019 v.76 no.6 pp. 1041-1055
- Kupffer cells; antigen-antibody complex; celiac disease; cytokines; dendritic cells; humans; immunity; immunoglobulin A; inflammation; inflammatory bowel disease; monocytes; neoplasms; neutralization; pathogenesis; pathogens; receptors; rheumatoid arthritis; therapeutics
- ... The prevailing concept regarding the immunological function of immunoglobulin A (IgA) is that it binds to and neutralizes pathogens to prevent infection at mucosal sites of the body. However, recently, it has become clear that in humans IgA is also able to actively contribute to the initiation of inflammation, both at mucosal and non-mucosal sites. This additional function of IgA is initiated by t ...