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1. Focus on Nutritional Aspects of Sarcopenia in Diabetes: Current Evidence and Remarks for Future Research

Author:
Christian Göbl; Andrea Tura
Source:
Nutrients 2022 v.14 no.2 pp. -
ISSN:
2072-6643
Subject:
diabetes,   etc   ; muscle tissues; sarcopenia;     Show all 3 Subjects
Abstract:
... Sarcopenia has been defined as a progressive and generalized loss of muscle mass that can be observed after the age of 40 years, with a rate of deterioration of about 8% every ten years up to 70 years, and 15–25% thereafter [...] ...
DOI:
10.3390/nu14020312

2. Multistage Photoactivatable Zinc-Responsive Nanodevices for Monitoring and Regulating Dysfunctional Islet β-Cells

Author:
Shan Huang; Yuexin Song; Huiqin Yao; Qianhao Min; Jian-Rong Zhang; Jun-Jie Zhu
Source:
Analytical chemistry 2022 v.94 no.17 pp. 6607-6614
ISSN:
1520-6882
Subject:
diabetes,   etc   ; analytical chemistry; satellites;     Show all 3 Subjects
Abstract:
... The dysfunctional islet β-cell triggered by excessive deposition of Zn²⁺ constituted a striking indicator of the occurrence of diabetic disease. However, it remained a formidable challenge to reflect the real-time function of β-cell by monitoring the Zn²⁺ content. Herein, multistage photoactivatable Zn²⁺-responsive nanodevice (denoted as AD2@USD1) was presented for sensing, regulating, and evaluat ...
DOI:
10.1021/acs.analchem.2c00892

3. Do oscillations in pancreatic islets require pacemaker cells?

Author:
Bradford E Peercy; Arthur S Sherman
Source:
Journal of biosciences 2022 v.47 no.1 pp. 14
ISSN:
0250-5991
Subject:
diabetes,   etc   ; calcium; case studies; insulin;     Show all 4 Subjects
Abstract:
... The pancreatic islets of Langerhans are biomedically important because they are home to the beta cells that secrete insulin and are hence important for understanding diabetes. They are also an important case study for the mechanisms of bursting oscillations and how these oscillations emerge from the electrical coupling of highly heterogeneous cells. Early work has pointed to a voting/democratic pa ...
DOI:
10.1007/s12038-021-00251-6

4. Metabolites of Gut Microbiota and Possible Implication in Development of Diabetes Mellitus

Author:
Zinan Guo; Jingjin Pan; Hanyue Zhu; Zhen-Yu Chen
Source:
Journal of agricultural and food chemistry 2022 v.70 no.20 pp. 5945-5960
ISSN:
1520-5118
Subject:
gestational diabetes; insulin-dependent diabetes mellitus; noninsulin-dependent diabetes mellitus,   etc   ; diet; digestive system; endotoxins; food chemistry; genetics; glucose; hyperglycemia; inflammation; insulin resistance; intestinal microorganisms; lipopolysaccharides; metabolism; metabolites; obesity; people;     Show all 18 Subjects
Abstract:
... Diabetes mellitus is characterized by having a disorder of glucose metabolism. The types of diabetes mellitus include type 1 diabetes mellitus, type 2 diabetes mellitus, gestational diabetes mellitus, and other specific types of diabetes mellitus. Many risk factors contribute to diabetes mellitus mainly including genetics, environment, obesity, and diet. In the recent years, gut microbiota has bee ...
DOI:
10.1021/acs.jafc.1c07851

5. 2022 National Standards for Diabetes Self-Management Education and Support

Author:
Jody Davis; Amy Hess Fischl; Joni Beck; Lillian Browning; Amy Carter; Jo Ellen Condon; Michelle Dennison; Terri Francis; Peter J. Hughes; Stephen Jaime; Ka Hei Karen Lau; Teresa McArthur; Karen McAvoy; Michelle Magee; Olivia Newby; Stephen W. Ponder; Uzma Quraishi; Kelly Rawlings; Julia Socke; Michelle Stancil; Sacha Uelmen; Suzanne Villalobos
Source:
The science of diabetes self-management and care 2022 v.48 no.1 pp. 44-59
ISSN:
2635-0114
Subject:
diabetes,   etc   ; education; health services; stakeholders; therapeutics;     Show all 5 Subjects
Abstract:
... The National Standards for Diabetes Self-Management Education and Support (DSMES) provide guidance and evidence-based, quality practice for all DSMES services. Due to the dynamic nature of health care and diabetes research, the National Standards are reviewed and revised approximately every 5 years by key stakeholders and experts within the diabetes care and education community. For each revision, ...
DOI:
10.1177/26350106211072203

6. Degradable methacrylic acid-based synthetic hydrogel for subcutaneous islet transplantation

Author:
Sean M. Kinney; Krystal Ortaleza; Alexander E. Vlahos; Michael V. Sefton
Source:
Biomaterials 2022 v.281 pp. 121342
ISSN:
0142-9612
Subject:
diabetes,   etc   ; biocompatible materials; hydrogels; insulin; therapeutics;     Show all 5 Subjects
Abstract:
... Islet transplantation is a promising regenerative therapy that would reduce the dependence of type 1 diabetic patients on insulin injections. However, islet transplantation is not yet widely available, in part because there is no ideal transplant site. The subcutaneous space has been highlighted as a promising transplant site, but it does not have the vasculature required to support an islet graft ...
DOI:
10.1016/j.biomaterials.2021.121342

7. Genus Aloe as sources of antidiabetic, antihyperglycemic and hypoglycemic agents: A review

Author:
Mutiu Idowu Kazeem; Habeeb Adebodun Bankole; Azeez Ayomide Fatai; Gbemisola Morounke Saibu; Adedoja Dorcas Wusu
Source:
South African journal of botany 2022 pp. -
ISSN:
0254-6299
Subject:
diabetes mellitus,   etc   ; botany; glycemic effect; inflammation;     Show all 4 Subjects
Abstract:
... Of all medicinal plants used to treat ailments, the genus Aloe represents one of the commonest. They manage various pathological conditions, including inflammation, infection, cancer and diabetes mellitus. There are specific reports on the hypoglycemic and antidiabetic potential of different species of Aloe. Still, there is a shortage of comprehensive reports which present all Aloe species with an ...
DOI:
10.1016/j.sajb.2022.05.041

8. LXR activation ameliorates high glucose stress-induced aberrant mitochondrial dynamics via downregulation of Calpain1 expression in H9c2 cardiomyoblasts

Author:
Jiejin Lin; Fengdan Wang; Ge Jiang; Tiantian Zhang; Junfeng Zhang; Qing He; Yuqi Fan
Source:
Biochemical and biophysical research communications 2022 v.614 pp. 145-152
ISSN:
0006-291X
Subject:
diabetes,   etc   ; cardiomyopathy; cardioprotective effect; glucose; mitochondria; research;     Show all 6 Subjects
Abstract:
... Liver-X-receptor (LXR) has previously been shown to exert a cardioprotective effect against the development of diabetic cardiomyopathy (DCM) associated with a reduction in mitochondrial dysfunction. However, the underlying mechanism by which LXR activation attenuates the structural and functional mitochondrial impairments caused by high glucose (HG) stress remains unclear. We demonstrate here that ...
DOI:
10.1016/j.bbrc.2022.05.025

9. Omeprazole inhibits α-glucosidase activity and the formation of nonenzymatic glycation products: Activity and mechanism

Author:
Chen Yu; Zi-Yi Yu; Yi-Ting Wen; Wei-Ming Chai; Lin-Jun Wang; Mei-Zhen Lin
Source:
Journal of bioscience and bioengineering 2022 v.133 no.2 pp. 110-118
ISSN:
1389-1723
Subject:
diabetes,   etc   ; enzyme kinetics; fluorescence; glycation; hydrogen; hydrophobicity;     Show all 6 Subjects
Abstract:
... In this study, the inhibitory effect and mechanism of omeprazole on α-glucosidase and nonenzymatic glycation were investigated in vitro by using multi-spectroscopic methods and molecular docking. Enzyme kinetic results showed that omeprazole inhibited α-glucosidase in a reversible and noncompetitive manner (IC₅₀= 0.595 ± 0.003 mM). The results from fluorescence quenching and thermomechanical analy ...
DOI:
10.1016/j.jbiosc.2021.10.007

10. The actions of C-peptide in HEK293 cells are dependent upon insulin and extracellular glucose concentrations

Author:
Jacqueline L. Rossiter; Lauren J. Redlinger; Grant R. Kolar; Willis K. Samson; Gina L.C. Yosten
Source:
Peptides 2022 v.150 pp. 170718
ISSN:
0196-9781
Subject:
diabetes,   etc   ; c-peptide; glucose; humans; peptides; therapeutics;     Show all 6 Subjects
Abstract:
... Connecting peptide, or C-peptide, is a part of the insulin prohormone and is essential for the proper folding and processing of the mature insulin peptide. C-peptide is released from the same beta cell secretory granules as insulin in equimolar amounts. However, due to their relative stabilities in plasma, the two peptides are detected in the circulation at ratios of approximately 4:1 to 6:1 (C-pe ...
DOI:
10.1016/j.peptides.2021.170718

11. Evaluation of a Type 2 diabetes risk reduction online program for women with recent gestational diabetes: a randomised trial

Author:
Rachael Taylor; Megan E. Rollo; Jennifer N. Baldwin; Melinda Hutchesson; Elroy J. Aguiar; Katie Wynne; Ashley Young; Robin Callister; Clare E. Collins
Source:
international journal of behavioral nutrition and physical activity 2022 v.19 no.1 pp. 35
ISSN:
1479-5868
Subject:
gestational diabetes; noninsulin-dependent diabetes mellitus,   etc   ; Internet; food quality; obesity; physical activity; quality of life; risk reduction; self-efficacy; surveys; New Zealand;     Show all 11 Subjects
Abstract:
... BACKGROUND: To evaluate the preliminary efficacy, feasibility and acceptability of the 3-month Body Balance Beyond (BBB) online program among Australian women with overweight/obesity and recent gestational diabetes mellitus. METHODS: Women were randomised into either: 1) High Personalisation (HP) (access to ‘BBB’ website, video coaching sessions, text message support); 2) Medium Personalisation (M ...
DOI:
10.1186/s12966-022-01275-3

12. A touch-actuated glucose sensor fully integrated with microneedle array and reverse iontophoresis for diabetes monitoring

Author:
Yanxiang Cheng; Xia Gong; Jian Yang; Guizhou Zheng; Ying Zheng; Yanjun Li; Yunsheng Xu; Gang Nie; Xi Xie; Meiwan Chen; Changqing Yi; Lelun Jiang
Source:
Biosensors & bioelectronics 2022 v.203 pp. 114026
ISSN:
0956-5663
Subject:
diabetes,   etc   ; biomarkers; biosensors; blood; electrochemistry; glucose; mobile telephones;     Show all 7 Subjects
Abstract:
... The development of non-invasive biosensor for monitoring glucose in interstitial fluid (ISF) is still challenging, because ISF extraction through classical reverse iontophoresis (RI) is limited by low extraction flux and consistency. Here, we developed a touch-actuated biosensor for monitoring glucose in ISF. The biosensor is composed of three main components: 1) the solid microneedle array (MA) f ...
DOI:
10.1016/j.bios.2022.114026

13. An on-line detection system for screening small molecule inhibitors of α-Amylase and α-Glucosidase in Prunus mume

Author:
Xiaoke Nan; Weijuan Jia; Yuankuan Zhang; Hong Wang; Zongtao Lin; Shizhong Chen
Source:
Journal of chromatography 2022 v.1663 pp. 462754
ISSN:
0021-9673
Subject:
diabetes,   etc   ; Prunus mume; alpha-amylase; chromatography; fluorescence; prototypes;     Show all 6 Subjects
Abstract:
... High-throughput screening of inhibitors from natural products is an efficient approach to target key enzymes in diabetes progression. In this study, an on-line detection system was established for the first time to rapidly screen inhibitors of α-amylase and α-glucosidase from Prunus mume. Among 28 identified compounds, 26 and 21 compounds showed strong inhibitory effect against α-amylase and α-glu ...
DOI:
10.1016/j.chroma.2021.462754

14. STING activation promotes inflammatory response and delays skin wound healing in diabetic mice

Author:
Zhang Feng; Chengyu Zang; Linfeng Zhang; Siyuan Yin; Qianqian Zhuang; Xiaojie Wang
Source:
Biochemical and biophysical research communications 2022 v.611 pp. 126-131
ISSN:
0006-291X
Subject:
diabetes,   etc   ; autophagy; inflammation; interferons; keratinocytes; mice; rapamycin; research;     Show all 8 Subjects
Abstract:
... Sustained inflammatory responses delay wound repair in diabetic skin. The stimulator of interferon genes (STING) plays a vital role in the innate immune responses. However, its function in diabetic skin wound repair, and the underlying mechanism remains unclear. Here, we reported that STING activation is a pathogenic marker that correlates with delayed wound repair in diabetic skin. Firstly, we fo ...
DOI:
10.1016/j.bbrc.2022.04.085

15. Saurauia vulcani (Korth.) as herbal medicine potential from North Sumatera, Indonesia: A literature review

Author:
Muhammad Fauzan Lubis; Poppy Anjelisa Zaitun Hasibuan; Hafid Syahputra; Chemayanti Surbakti; Ririn Astyka
Source:
Heliyon 2022 v.8 no.4 pp. e09249
ISSN:
2405-8440
Subject:
diabetes,   etc   ; herbal medicines; immunostimulants; secondary metabolites; therapeutics; Indonesia;     Show all 6 Subjects
Abstract:
... According to some studies, two-thirds of the world's plant species have therapeutic worth. Saurauia vulcani (Korth.) is one of them. This is something that can be found in Indonesia. Traditionally, this herb was known as pirdot and was used to cure diabetes. This article examines the scientific activities of pirdot leaves as well as their safety for usage. This study used a literature review artic ...
DOI:
10.1016/j.heliyon.2022.e09249

16. GPR75: An exciting new target in metabolic syndrome and related disorders

Author:
Babar Murtaza; Faiza Asghar; Danish Patoli
Source:
Biochimie 2022 v.195 pp. 19-26
ISSN:
0300-9084
Subject:
diabetes,   etc   ; cerebrovascular disorders; hyperlipidemia; metabolic syndrome; morbidity; mortality; obesity;     Show all 7 Subjects
Abstract:
... The metabolic syndrome is a plethora of related disorders that are frequently associated with morbidity and mortality in addition to economic burden. While various treatment options are available, the need to understand the pathology and find new targets still remains. Recent data have suggested GPR75 as one such exciting target that has shown to a highly druggable potential. In this review, we ha ...
DOI:
10.1016/j.biochi.2022.01.005

17. In vitro testing indicates an accelerated rate of digestion of starch into glucose of cooked rice with the development of low amylose rice in China

Author:
Min Huang; Liqin Hu; Jiana Chen; Fangbo Cao
Source:
Food chemistry: X 2022 v.14 pp. 100278
ISSN:
2590-1575
Subject:
diabetes,   etc   ; amylose; digestion; food chemistry; glucose; rice; risk; China;     Show all 8 Subjects
Abstract:
... The consumption of low amylose rice has substantially increased in China in recent years. This in vitro study showed that the starch digestion process was distinctly different between a group of commercial rice samples (CR, n = 34) with low amylose content (14–20%) and a group of control rice samples (CK, n = 16) with high amylose content (24–30%). In particular, the CR group had an active digesti ...
DOI:
10.1016/j.fochx.2022.100278

18. Methods: A new protocol for in vitro red blood cell glycation

Author:
Marcus V. Batista da Silva; Analía I. Alet; Horacio V. Castellini; Bibiana D. Riquelme
Source:
Comparative biochemistry and physiology 2022 v.264 pp. 111109
ISSN:
1095-6433
Subject:
diabetes,   etc   ; erythrocytes; glucose; glycation; glycohemoglobin; hyperglycemia; models; temperature; viscoelasticity;     Show all 9 Subjects
Abstract:
... During diabetes, the characteristic hyperglycemia can induce red blood cell glycation. Several researchers have proposed different protocols to perform an in vitro model to study this phenomenon. In this article, some of the most important in vitro glycation protocols available in the bibliography were compared to each other. The incubation parameters as the suspension medium, glucose concentratio ...
DOI:
10.1016/j.cbpa.2021.111109

19. Risk factors for Veteran food insecurity: findings from a National US Department of Veterans Affairs Food Insecurity Screener

Author:
Alicia J Cohen; David M Dosa; James L Rudolph; Christopher W Halladay; Michele Heisler; Kali S Thomas
Source:
Public health nutrition 2022 v.25 no.4 pp. 819-828
ISSN:
1475-2727
Subject:
diabetes,   etc   ; color; cross-sectional studies; food security; regression analysis;     Show all 5 Subjects
Abstract:
... Food insecurity is associated with numerous adverse health outcomes. The US Veterans Health Administration (VHA) began universal food insecurity screening in 2017. This study examined prevalence and correlates of food insecurity among Veterans screened. Retrospective cross-sectional study using VHA administrative data. Multivariable logistic regression models were estimated to identify sociodemogr ...
DOI:
10.1017/S1368980021004584

20. Emergence of microneedles as a potential therapeutics in diabetes mellitus

Author:
Ishrat Zahoor; Sukhbir Singh; Tapan Behl; Neelam Sharma; Tanveer Naved; Vetriselvan Subramaniyan; Shivkanya Fuloria; Neeraj Kumar Fuloria; Saurabh Bhatia; Ahmed Al-Harrasi; Lotfi Aleya; Shahid Nazir Wani; Celia Vargas-De-La-Cruz; Simona Bungau
Source:
Environmental science and pollution research 2022 v.29 no.3 pp. 3302-3322
ISSN:
0944-1344
Subject:
insulin-dependent diabetes mellitus; noninsulin-dependent diabetes mellitus,   etc   ; blood glucose; gastrointestinal system; humans; hydrogels; insulin; insulin replacement therapy; markets; metabolism; pancreas; pollution; research; risk; transdermal application;     Show all 15 Subjects
Abstract:
... Diabetes mellitus is a severe condition in which the pancreas produces inadequate insulin or the insulin generated is ineffective for utilisation by the body; as a result, insulin therapy is required for control blood sugar levels in patients having type 1 diabetes and is widely recommended in advanced type 2 diabetes patients with uncontrolled diabetes despite dual oral therapy, while subcutaneou ...
DOI:
10.1007/s11356-021-17346-0