An official website of the United States government
Here’s how you know
Official websites use .gov
A .gov website belongs to an official government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.
... Sarcopenia has been defined as a progressive and generalized loss of muscle mass that can be observed after the age of 40 years, with a rate of deterioration of about 8% every ten years up to 70 years, and 15–25% thereafter [...] ...
... The dysfunctional islet β-cell triggered by excessive deposition of Zn²⁺ constituted a striking indicator of the occurrence of diabetic disease. However, it remained a formidable challenge to reflect the real-time function of β-cell by monitoring the Zn²⁺ content. Herein, multistage photoactivatable Zn²⁺-responsive nanodevice (denoted as AD2@USD1) was presented for sensing, regulating, and evaluat ...
... The pancreatic islets of Langerhans are biomedically important because they are home to the beta cells that secrete insulin and are hence important for understanding diabetes. They are also an important case study for the mechanisms of bursting oscillations and how these oscillations emerge from the electrical coupling of highly heterogeneous cells. Early work has pointed to a voting/democratic pa ...
... Diabetes mellitus is characterized by having a disorder of glucose metabolism. The types of diabetes mellitus include type 1 diabetes mellitus, type 2 diabetes mellitus, gestational diabetes mellitus, and other specific types of diabetes mellitus. Many risk factors contribute to diabetes mellitus mainly including genetics, environment, obesity, and diet. In the recent years, gut microbiota has bee ...
Jody Davis; Amy Hess Fischl; Joni Beck; Lillian Browning; Amy Carter; Jo Ellen Condon; Michelle Dennison; Terri Francis; Peter J. Hughes; Stephen Jaime; Ka Hei Karen Lau; Teresa McArthur; Karen McAvoy; Michelle Magee; Olivia Newby; Stephen W. Ponder; Uzma Quraishi; Kelly Rawlings; Julia Socke; Michelle Stancil; Sacha Uelmen; Suzanne Villalobos
diabetes, etc ; education; health services; stakeholders; therapeutics; Show all 5 Subjects
Abstract:
... The National Standards for Diabetes Self-Management Education and Support (DSMES) provide guidance and evidence-based, quality practice for all DSMES services. Due to the dynamic nature of health care and diabetes research, the National Standards are reviewed and revised approximately every 5 years by key stakeholders and experts within the diabetes care and education community. For each revision, ...
diabetes, etc ; biocompatible materials; hydrogels; insulin; therapeutics; Show all 5 Subjects
Abstract:
... Islet transplantation is a promising regenerative therapy that would reduce the dependence of type 1 diabetic patients on insulin injections. However, islet transplantation is not yet widely available, in part because there is no ideal transplant site. The subcutaneous space has been highlighted as a promising transplant site, but it does not have the vasculature required to support an islet graft ...
diabetes mellitus, etc ; botany; glycemic effect; inflammation; Show all 4 Subjects
Abstract:
... Of all medicinal plants used to treat ailments, the genus Aloe represents one of the commonest. They manage various pathological conditions, including inflammation, infection, cancer and diabetes mellitus. There are specific reports on the hypoglycemic and antidiabetic potential of different species of Aloe. Still, there is a shortage of comprehensive reports which present all Aloe species with an ...
diabetes, etc ; cardiomyopathy; cardioprotective effect; glucose; mitochondria; research; Show all 6 Subjects
Abstract:
... Liver-X-receptor (LXR) has previously been shown to exert a cardioprotective effect against the development of diabetic cardiomyopathy (DCM) associated with a reduction in mitochondrial dysfunction. However, the underlying mechanism by which LXR activation attenuates the structural and functional mitochondrial impairments caused by high glucose (HG) stress remains unclear. We demonstrate here that ...
diabetes, etc ; enzyme kinetics; fluorescence; glycation; hydrogen; hydrophobicity; Show all 6 Subjects
Abstract:
... In this study, the inhibitory effect and mechanism of omeprazole on α-glucosidase and nonenzymatic glycation were investigated in vitro by using multi-spectroscopic methods and molecular docking. Enzyme kinetic results showed that omeprazole inhibited α-glucosidase in a reversible and noncompetitive manner (IC₅₀= 0.595 ± 0.003 mM). The results from fluorescence quenching and thermomechanical analy ...
diabetes, etc ; c-peptide; glucose; humans; peptides; therapeutics; Show all 6 Subjects
Abstract:
... Connecting peptide, or C-peptide, is a part of the insulin prohormone and is essential for the proper folding and processing of the mature insulin peptide. C-peptide is released from the same beta cell secretory granules as insulin in equimolar amounts. However, due to their relative stabilities in plasma, the two peptides are detected in the circulation at ratios of approximately 4:1 to 6:1 (C-pe ...
gestational diabetes; noninsulin-dependent diabetes mellitus, etc ; Internet; food quality; obesity; physical activity; quality of life; risk reduction; self-efficacy; surveys; New Zealand; Show all 11 Subjects
Abstract:
... BACKGROUND: To evaluate the preliminary efficacy, feasibility and acceptability of the 3-month Body Balance Beyond (BBB) online program among Australian women with overweight/obesity and recent gestational diabetes mellitus. METHODS: Women were randomised into either: 1) High Personalisation (HP) (access to ‘BBB’ website, video coaching sessions, text message support); 2) Medium Personalisation (M ...
diabetes, etc ; biomarkers; biosensors; blood; electrochemistry; glucose; mobile telephones; Show all 7 Subjects
Abstract:
... The development of non-invasive biosensor for monitoring glucose in interstitial fluid (ISF) is still challenging, because ISF extraction through classical reverse iontophoresis (RI) is limited by low extraction flux and consistency. Here, we developed a touch-actuated biosensor for monitoring glucose in ISF. The biosensor is composed of three main components: 1) the solid microneedle array (MA) f ...
diabetes, etc ; Prunus mume; alpha-amylase; chromatography; fluorescence; prototypes; Show all 6 Subjects
Abstract:
... High-throughput screening of inhibitors from natural products is an efficient approach to target key enzymes in diabetes progression. In this study, an on-line detection system was established for the first time to rapidly screen inhibitors of α-amylase and α-glucosidase from Prunus mume. Among 28 identified compounds, 26 and 21 compounds showed strong inhibitory effect against α-amylase and α-glu ...
diabetes, etc ; autophagy; inflammation; interferons; keratinocytes; mice; rapamycin; research; Show all 8 Subjects
Abstract:
... Sustained inflammatory responses delay wound repair in diabetic skin. The stimulator of interferon genes (STING) plays a vital role in the innate immune responses. However, its function in diabetic skin wound repair, and the underlying mechanism remains unclear. Here, we reported that STING activation is a pathogenic marker that correlates with delayed wound repair in diabetic skin. Firstly, we fo ...
diabetes, etc ; herbal medicines; immunostimulants; secondary metabolites; therapeutics; Indonesia; Show all 6 Subjects
Abstract:
... According to some studies, two-thirds of the world's plant species have therapeutic worth. Saurauia vulcani (Korth.) is one of them. This is something that can be found in Indonesia. Traditionally, this herb was known as pirdot and was used to cure diabetes. This article examines the scientific activities of pirdot leaves as well as their safety for usage. This study used a literature review artic ...
diabetes, etc ; cerebrovascular disorders; hyperlipidemia; metabolic syndrome; morbidity; mortality; obesity; Show all 7 Subjects
Abstract:
... The metabolic syndrome is a plethora of related disorders that are frequently associated with morbidity and mortality in addition to economic burden. While various treatment options are available, the need to understand the pathology and find new targets still remains. Recent data have suggested GPR75 as one such exciting target that has shown to a highly druggable potential. In this review, we ha ...
diabetes, etc ; amylose; digestion; food chemistry; glucose; rice; risk; China; Show all 8 Subjects
Abstract:
... The consumption of low amylose rice has substantially increased in China in recent years. This in vitro study showed that the starch digestion process was distinctly different between a group of commercial rice samples (CR, n = 34) with low amylose content (14–20%) and a group of control rice samples (CK, n = 16) with high amylose content (24–30%). In particular, the CR group had an active digesti ...
diabetes, etc ; erythrocytes; glucose; glycation; glycohemoglobin; hyperglycemia; models; temperature; viscoelasticity; Show all 9 Subjects
Abstract:
... During diabetes, the characteristic hyperglycemia can induce red blood cell glycation. Several researchers have proposed different protocols to perform an in vitro model to study this phenomenon. In this article, some of the most important in vitro glycation protocols available in the bibliography were compared to each other. The incubation parameters as the suspension medium, glucose concentratio ...
diabetes, etc ; color; cross-sectional studies; food security; regression analysis; Show all 5 Subjects
Abstract:
... Food insecurity is associated with numerous adverse health outcomes. The US Veterans Health Administration (VHA) began universal food insecurity screening in 2017. This study examined prevalence and correlates of food insecurity among Veterans screened. Retrospective cross-sectional study using VHA administrative data. Multivariable logistic regression models were estimated to identify sociodemogr ...
... Diabetes mellitus is a severe condition in which the pancreas produces inadequate insulin or the insulin generated is ineffective for utilisation by the body; as a result, insulin therapy is required for control blood sugar levels in patients having type 1 diabetes and is widely recommended in advanced type 2 diabetes patients with uncontrolled diabetes despite dual oral therapy, while subcutaneou ...