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... Foodborne pathogens are a major cause of diarrheal disease worldwide, but also constitute a severe threat for the spread of antimicrobial-resistant bacteria from livestock via food products to humans [...] ...
... Porcine epidemic diarrhoea virus (PEDV) infects pigs of all ages causing vomiting and diarrhoea. PEDV is transmitted via the oral–faecal route, and a very low dose is enough to infect susceptible pigs, resulting in significant production losses. This short communication aims to describe the introduction of PEDV into a 10,000‐sow farrow‐to‐wean farm located in northwest Mexico. Following the onset ...
Porcine epidemic diarrhea virus; diarrhea, etc ; apoptosis; dose response; industry; interleukin-6; interleukin-8; intestines; microbiology; therapeutics; Show all 10 Subjects
Abstract:
... Porcine epidemic diarrhea virus (PEDV) is one of the main pathogens causing severe diarrhea in piglets. Infection of the host induces apoptosis, causing huge economic losses to the pig industry. At present, the preventive and therapeutic effects of commercial vaccines are not satisfactory, and it is necessary to develop new anti-PEDV drugs. In this study, we screened the PEDV-inhibiting drug Buddl ...
... Bovine viral diarrhoea virus (BVDV) is one of the most leading causes of diarrhoea in many species of animals including camelids. Special attention is being paid to studying various aspects of the BVDV infection, pathogenesis, epidemiology, diagnosis and vaccines in the bovine species. Little is still known about these aspects in camelids especially dromedaries. The development of accurate diagnos ...
Porcine epidemic diarrhea virus; diarrhea, etc ; body weight; drug therapy; intestines; mortality; pathogens; piglets; viral load; virus replication; viruses; Show all 11 Subjects
Abstract:
... Porcine epidemic diarrhea virus (PEDV) belongs to the genus Alphacoronavirus of the family Coronaviridae that causes severe diarrhea and high mortality in neonatal suckling piglets. Currently, there is no effective medication against this pathogen. Cepharanthine (CEP), tetrandrine (TET), and fangchinoline (FAN) are natural bis-benzylisoquinoline alkaloids with anti-inflammatory, antitumor, and ant ...
Porcine epidemic diarrhea virus; diarrhea, etc ; acetyltransferases; financial economics; metabolism; mortality; ornithine decarboxylase; oxidoreductases; protein content; research; spermine; viruses; Show all 12 Subjects
Abstract:
... Porcine epidemic diarrhea virus (PEDV) is an alpha-coronavirus that causes epidemic diarrhea in swines. The mortality of PEDV infection in one-week-old piglets is extremely high, which causes a huge significant economic loss to the global pig husbandry and blocks its healthy development. There was a lack of adequate studies to elucidate pathogenic mechanism associated with PEDV infection. In the p ...
diarrhea, etc ; economic valuation; surveys; water; Zambia; Show all 5 Subjects
Abstract:
... Access to safe water sources remains scarce in sub-Saharan African countries. We estimate the economic value of safe water from newly constructed boreholes in rural Zambia. Our quasi-experimental setting allows us to estimate the revealed preference measure of new safe water sources in a causal way, empowered by precise information on water collection and distance to new facilities. We show that t ...
... Porcine Epidemic Diarrhea (PED) is a highly contagious intestinal disease which mostly caused by Porcine Epidemic Diarrhea Virus (PEDV). The PED has caused huge economic losses to the pig industry all over the world and a valid PEDV vaccine is needed to prevent the infection. In this study, we constructed expression plasmid based on the spike (S) gene of the epidemic PEDV strain. The recombinant e ...
diarrhea, etc ; digital libraries; metagenomics; monitoring; systematic review; Show all 5 Subjects
Abstract:
... To analyze the application of the metagenomics method in the identification of viral infectious agents that lead to diarrhea outbreaks. This study is a systematic review, which looked for publications on the following platforms: PubMed, Scientific Electronic Library Online (SciELO), LILACS and CAPES periodicals, conducted according to the PRISMA methodology, investigating in the literary compositi ...
... BACKGROUND: From the 1078 diarrhea stools tested in our survey from 2017 to 2020 in local area of China, PEDV was the key pathogen that was closely related to the death of piglets with diarrhea. In addition, coinfection of PEDV-positive samples with BVDV reached 17.24%. Although BVDV infection in swine is typically subclinical, the effect of PEDV and BVDV coinfection on disease severity and the po ...
Porcine epidemic diarrhea virus; diarrhea, etc ; enteropathogens; gene expression; gene expression regulation; genes; green fluorescent protein; microbiology; mortality; reverse genetics; transcription (genetics); Show all 11 Subjects
Abstract:
... Porcine epidemic diarrhea virus (PEDV) is a highly contagious enteropathogenic coronavirus causing severe watery diarrhea and high mortality in piglets. In order to investigate the role of the transcription regulatory sequences (TRSs) in regulation of gene expression and replication of PEDV, the enhanced green fluorescent protein (EGFP) gene, under control of different TRSs of PEDV, were inserted ...
... Bovine viral diarrhoea virus (BVDV) infection is a worldwide distributed animal disease. BVDV is the causal agent of congenital defects, diarrhea, reproductive failure, and contaminating biological products. Virus Neutralization test (VNT) as a gold standard method is used for detection of BVDV. Although this assay is very sensitive and specific, it has disadvantages including requires to an exper ...
diarrhea, etc ; Enterocytozoon bieneusi; diagnostic techniques; microscopy; patients; Cuba; Show all 6 Subjects
Abstract:
... The aetiology of diarrhoea in a patient in Cuba with HIV was investigated. Although molecular diagnostics are still not used in many under-resourced settings, here traditional methods were supported by use of PCR. This approach enabled detection of a dual infection (Cystoisospora belli and Enterocytozoon bieneusi), the latter of which was not identified by microscopy with Didier's trichromic stain ...
diarrhea, etc ; Cryptosporidium; animal models; curcumin; drugs; parasitology; rabbits; Show all 7 Subjects
Abstract:
... Cryptosporidium is one of the leading causes of diarrheal disease in humans and animals, which can be severe and deadly in neonates and immunocompromised hosts. Studies on the biology of Cryptosporidium and drug discovery efforts have been hindered by a number of factors including the limited availability of animal models. Here, we report the establishment and characterization of an immunocompeten ...
Kristen M. Weishaar; Zachary M. Wright; Mona P. Rosenberg; Gerald S. Post; Jennifer A. McDaniel; Craig A. Clifford; Brenda S. Phillips; Philip J. Bergman; Elissa K. Randall; Anne C. Avery; Douglas H. Thamm; Abigail A. Christman Hull; Cathy M. Gust; Ann R. Donoghue
diarrhea, etc ; appetite; drug therapy; lymphoma; placebos; veterinary medicine; Show all 6 Subjects
Abstract:
... BACKGROUND: Rabacfosadine (RAB, Tanovea‐CA1) is a novel chemotherapy agent conditionally approved for the treatment of lymphoma in dogs. HYPOTHESIS/OBJECTIVES: To determine the efficacy and safety of RAB in dogs with lymphoma. ANIMALS: One hundred and fifty‐eight client‐owned dogs with naïve or relapsed multicentric lymphoma were prospectively enrolled from January to October 2019. METHODS: Dogs w ...
diarrhea, etc ; DNA; cattle; epidemiology; farms; microscopy; parasitology; Taiwan; Show all 8 Subjects
Abstract:
... Cryptosporidium spp. is a group of protozoans that cause diarrheal disease in both humans and animals. In Taiwan, very little information is available about the epidemiology of Cryptosporidium spp. in domesticated animals, especially in Eastern Taiwan where agriculture is one of the main industries. Therefore, this study aimed to investigate the occurrence of Cryptosporidium spp. in livestock in H ...
diarrhea, etc ; Norovirus; childhood; cohort studies; complications (disease); malnutrition; Show all 6 Subjects
Abstract:
... The prevalence of norovirus infections in different geographical locations and their attribution to childhood diarrhea is well established. However, there are no reports showing possible relationships of different norovirus genogroups with subsequent childhood malnutrition. In this study, we attempted to establish a potential association between asymptomatic norovirus infections with childhood gro ...
diarrhea, etc ; Clostridium difficile; disease transmission; dogs; females; genomics; Show all 6 Subjects
Abstract:
... We describe a case of interspecies transmission of toxigenic Clostridioides difficile involving a female and her dog, both with diarrhea without another diagnosis. Genomic analysis showed that isolates were grouped into MLST clade I, closely related to ribotype 020 and shared identical genotypes. ...
diarrhea, etc ; altitude; feet; geometry; hydraulic engineering; journals; prediction; Show all 7 Subjects
Abstract:
... Experiments were performed for local scour at a complex pier with two inclined, rectangular columns footed on a group of circular piles with a pile cap. The research fills a gap in existing literature, where studies for complex piers have considered a single, vertical column. The laboratory campaign involved the variation of the pile diameter and arrangement, and of the cap thickness and elevation ...
diarrhea, etc ; Cryptosporidium parvum; cryptosporidiosis; farms; immunoassays; industrialization; China; Show all 7 Subjects
Abstract:
... Cryptosporidium parvum is a major zoonotic pathogen responsible for outbreaks of severe diarrhoea in humans and calves. Almost all investigations of cryptosporidiosis outbreaks caused by C. parvum have focused on its IIa subtype family in industrialized nations. From December 2018 to April 2019, approximately 200 neonatal calves on a large cattle farm in Hebei Province, China, were diagnosed with ...