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1. Rare bioparticle detection via deep metric learning

Author:
Luo, Shaobo; Shi, Yuzhi; Chin, Lip Ket; Zhang, Yi; Wen, Bihan; Sun, Ying; Nguyen, Binh T. T.; Chierchia, Giovanni; Talbot, Hugues; Bourouina, Tarik; Jiang, Xudong; Liu, Ai-Qun
Source:
RSC advances 2021 v.11 no.29 pp. 17603-17610
ISSN:
2046-2069
Subject:
disease diagnosis,   etc   ; Cryptosporidium; Giardia; bioimaging; flow cytometry;     Show all 5 Subjects
Abstract:
... Recent deep neural networks have shown superb performance in analyzing bioimages for disease diagnosis and bioparticle classification. Conventional deep neural networks use simple classifiers such as SoftMax to obtain highly accurate results. However, they have limitations in many practical applications that require both low false alarm rate and high recovery rate, e.g., rare bioparticle detection ...
DOI:
10.1039/d1ra02869c

2. A DNA small molecular probe with increasing K⁺ concentration promoted selectivity

Author:
Gong, Ya-Ping; Yang, Jian; Fang, Ji-Wang; Li, Qian; Yu, Zhi-Yong; Guan, Aijiao; Gong, Han-Yuan
Source:
RSC advances 2021 v.11 no.25 pp. 15030-15035
ISSN:
2046-2069
Subject:
disease diagnosis,   etc   ; DNA probes; fluorescence; salinity;     Show all 4 Subjects
Abstract:
... DNA small molecular probe study was considered as a promising approach to achieve DNA related disease diagnosis. Most related reports were performed under specific salinity. Herein, 4-imino-3-(pyridin-2-yl)-4H-quinolizine-1-carbonitrile (IPQC) was generated via a facile procedure with high yield (85%). It is found that IPQC could act as a universal probe for most tested ssDNA, dsDNA and G4 DNA in ...
DOI:
10.1039/d0ra06274j

3. Methodology for developing and evaluating diagnostic tools in Ayurveda – A review

Author:
Edavalath, Mukesh; Bharathan, Benil P.
Source:
Journal of Ayurveda and integrative medicine 2021 v.12 no.2 pp. 389-397
ISSN:
0975-9476
Subject:
disease diagnosis,   etc   ; Ayurvedic medicine; diagnostic techniques; patients;     Show all 4 Subjects
Abstract:
... Ayurveda has a holistic and person-centric approach towards health and disease, which in turn necessitates consideration of several factors in the process of a diagnostic workup. This concept of personalised diagnosis brings about a high level of variability among the clinicians with respect to their assessment methods and disease diagnosis. Developing and validating diagnostic tools for diseases ...
DOI:
10.1016/j.jaim.2021.01.009

4. Two radiographic methods for assessing left atrial enlargement and cardiac remodeling in dogs with myxomatous mitral valve disease

Author:
Vezzosi, T.; Puccinelli, C.; Citi, S.; Tognetti, R.
Source:
Journal of veterinary cardiology 2021 v.34 pp. 55-63
ISSN:
1760-2734
Subject:
disease diagnosis,   etc   ; dogs; echocardiography; heart; prediction; radiography;     Show all 6 Subjects
Abstract:
... Two radiographic measures of the left atrial (LA) size, the vertebral left atrial size (VLAS) and the radiographic left atrial dimension (RLAD), have been described in dogs. The aim of this study was to determine their feasibility and diagnostic value in the prediction of LA enlargement and clinical stage in dogs with myxomatous mitral valve disease (MMVD).111 client-owned dogs affected by MMVD.Re ...
DOI:
10.1016/j.jvc.2021.01.002

5. Fluid–Structure Interaction Analyses of Biological Systems Using Smoothed-Particle Hydrodynamics

Author:
Toma, Milan; Chan-Akeley, Rosalyn; Arias, Jonathan; Kurgansky, Gregory D.; Mao, Wenbin
Source:
Biology 2021 v.10 no.3
ISSN:
2079-7737
Subject:
disease diagnosis,   etc   ; humans; hydrodynamics; risk assessment; therapeutics;     Show all 5 Subjects
Abstract:
... Due to the inherent complexity of biological applications that more often than not include fluids and structures interacting together, the development of computational fluid–structure interaction models is necessary to achieve a quantitative understanding of their structure and function in both health and disease. The functions of biological structures usually include their interactions with the s ...
DOI:
10.3390/biology10030185

6. New methods of posturographic data analysis may improve the diagnostic value of static posturography in multiple sclerosis

Author:
Błaszczyk, Janusz W.; Cieślińska-Świder, Joanna; Orawiec, Renata
Source:
Heliyon 2021 v.7 no.2 pp. e06190
ISSN:
2405-8440
Subject:
disease diagnosis,   etc   ; neurons; posture; sclerosis; vision;     Show all 5 Subjects
Abstract:
... Early and accurate diagnosis of multiple sclerosis (MS) is crucial for its effective treatment. In MS diagnostic, neuronal networks that control posture and movement are of particular importance, which performance can be assessed using static posturography. Unfortunately, most of the commercially available posturographic platforms are not equipped with the appropriate procedures.To solve this prob ...
DOI:
10.1016/j.heliyon.2021.e06190

7. Peptide-based supramolecular hydrogels for bioimaging applications

Author:
Liu, Xiaoyang; Sun, Xianbao; Liang, Gaolin
Source:
Biomaterials science 2021 v.9 no.2 pp. 315-327
ISSN:
2047-4849
Subject:
disease diagnosis,   etc   ; biocompatibility; biocompatible materials; bioimaging; hydrogels;     Show all 5 Subjects
Abstract:
... Owing to their superior loading capacity and biocompatibility, imaging agent-conjugated (or encapsulated) peptide-based supramolecular hydrogels are capable of imaging in vivo biological events with enhanced signals. Notably, by rational design of the hydrogelators, the hydrogelation process can “smartly” occur on the pathological site (or region of interest), rendering precise and sensitive bioim ...
DOI:
10.1039/d0bm01020k

8. Integration of multi-objective PSO based feature selection and node centrality for medical datasets

Author:
Rostami, Mehrdad; Forouzandeh, Saman; Berahmand, Kamal; Soltani, Mina
Source:
Genomics 2020 v.112 no.6 pp. 4370-4384
ISSN:
0888-7543
Subject:
disease diagnosis,   etc   ; databases; models;     Show all 3 Subjects
Abstract:
... In the past decades, the rapid growth of computer and database technologies has led to the rapid growth of large-scale medical datasets. On the other, medical applications with high dimensional datasets that require high speed and accuracy are rapidly increasing. One of the dimensionality reduction approaches is feature selection that can increase the accuracy of the disease diagnosis and reduce i ...
DOI:
10.1016/j.ygeno.2020.07.027

9. Naked-eye detection of site-specific ssRNA and ssDNA using PAMmer-assisted CRISPR/Cas9 coupling with exponential amplification reaction

Author:
Wang, Xianfeng; Chen, Xiaolong; Chu, Chengxiang; Deng, Yuanyi; Yang, Mei; Huo, Danqun; Xu, Faliang; Hou, Changjun; Lv, Jiayi
Source:
Talanta 2021 v.233 pp. 122554
ISSN:
0039-9140
Subject:
disease diagnosis,   etc   ; CRISPR-Cas systems; blood serum; color; humans; mutation;     Show all 6 Subjects
Abstract:
... Accurate and effective detection of single-stranded nucleic acids is vital in both disease diagnosis and pathological studies. Hence, we develop a PAMmer-assisted CRISPR/Cas9 system mediated G4-EXPAR (Cas-G4EX) strategy for site-specific detection of ssRNA and ssDNA. PAMmer-assisted CRISPR/Cas9 executes the site-specific cleavage of target ssRNA or ssDNA and released product fragment with the desi ...
DOI:
10.1016/j.talanta.2021.122554

10. Lower critical concentration temperature as thermodynamic origin of syneresis: Case of kappa-carrageenan solution

Author:
Elmarhoum, Said; Ako, Komla
Source:
Carbohydrate polymers 2021 v.267 pp. 118191
ISSN:
0144-8617
Subject:
disease diagnosis,   etc   ; cell culture; gelatinization temperature; gels; kappa carrageenan; thermodynamics;     Show all 6 Subjects
Abstract:
... Polysaccharide ubiquity is trimmed for applications of low syneresis impact. This syneresis may be crucial for specific applications that are very sensitive to gel dimension stability, namely, 3D scaffolds for cell culture for disease diagnosis and tissue engineering. We hypothesized that the syneresis origin results from the kappa-carrageenan (kC) polysaccharide thermodynamic instability, and we ...
DOI:
10.1016/j.carbpol.2021.118191

11. Carbon-based nanomaterials for the detection of volatile organic compounds: A review

Author:
Yin, Feifei; Yue, Wenjing; Li, Yang; Gao, Song; Zhang, Chunwei; Kan, Hao; Niu, Hongsen; Wang, Wenxiao; Guo, Yunjian
Source:
Carbon 2021 v.180 pp. 274-297
ISSN:
0008-6223
Subject:
disease diagnosis,   etc   ; carbon nanotubes; graphene; volatile organic compounds;     Show all 4 Subjects
Abstract:
... Developing efficient sensing materials with superior sensing capabilities of sensitive, fast, selective detection of volatile organic compounds (VOCs) is necessary for fields like environmental gas monitoring and non-invasive disease diagnosis. Recently, carbon nanotubes, graphene, MXene, and other carbon-based nanomaterials have been paid much attention for possible use as high-performance VOCs s ...
DOI:
10.1016/j.carbon.2021.04.080

12. Ex-situ XPS analysis of yolk-shell Sb2O3/WO3 for ultra-fast acetone resistive sensor

Author:
Wang, Qiao; Wu, Hongchang; Wang, Yanrong; Li, Jianpeng; Yang, Yifan; Cheng, Xu; Luo, Yibing; An, Beixi; Pan, Xiaojun; Xie, Erqing
Source:
Journal of hazardous materials 2021 v.412 pp. 125175
ISSN:
0304-3894
Subject:
disease diagnosis,   etc   ; acetone; adsorption; desorption; detection limit; oxygen;     Show all 6 Subjects
Abstract:
... The preparation of fast, highly responsive and reliable gas sensing devices for the detection of acetone gas is considered to be a key challenge for the development of accurate disease diagnosis systems through exhaled respiratory gases. In the paper, yolk shell Sb₂O₃/WO₃ is synthesized and its gas sensing performance was studied by static test system. Special, the maximum response value of 1:1 Sb ...
DOI:
10.1016/j.jhazmat.2021.125175

13. Enzymatic dephosphorylation-triggered self-assembly of DNA amphiphiles

Author:
Zou, Jianmei; Gao, Qian; Nie, Jinfang; Zhang, Yun; Jin, Cheng
Source:
RSC advances 2021 v.11 no.30 pp. 18322-18325
ISSN:
2046-2069
Subject:
disease diagnosis,   etc   ; DNA; cancer therapy; hydrophobicity; oligonucleotides; surfactants;     Show all 6 Subjects
Abstract:
... In this work, phosphorylated lipid-conjugated oligonucleotide (DNA-lipid-P) has been synthesized to develop an enzyme-responsive self-assembly of DNA amphiphiles based on dephosphorylation-induced increase of hydrophobicity. Since elevated ALP level is a critical index in some diseases, ALP-triggered self-assembly of DNA amphiphiles shows promise in disease diagnosis and cancer treatment. ...
DOI:
10.1039/d1ra01668g

14. Intraepithelial Lymphocyte Cytometric Pattern Is a Useful Diagnostic Tool for Coeliac Disease Diagnosis Irrespective of Degree of Mucosal Damage and Age—A Validation Cohort

Author:
Ruiz-Ramírez, Pablo; Carreras, Gerard; Fajardo, Ingrid; Tristán, Eva; Carrasco, Anna; Salvador, Isabel; Zabana, Yamile; Andújar, Xavier; Ferrer, Carme; Horta, Diana; Loras, Carme; García-Puig, Roger; Fernández-Bañares, Fernando; Esteve, Maria
Source:
Nutrients 2021 v.13 no.5
ISSN:
2072-6643
Subject:
disease diagnosis,   etc   ; celiac disease; diagnostic techniques; flow cytometry; histology; serology;     Show all 6 Subjects
Abstract:
... Introduction: The study of intraepithelial lymphocytes (IEL) by flow cytometry is a useful tool in the diagnosis of coeliac disease (CD). Previous data showed that an increase in %TCRγδ⁺ and decrease of %CD3⁻ IEL constitute a typical CD cytometric pattern with a specificity of 100%. However, there are no data regarding whether there are differences in the %TCRγδ⁺ related to sex, age, titers of ser ...
DOI:
10.3390/nu13051684

15. Why is a picture ‘worth a thousand words’? Pictures as information in perceived helpfulness of online reviews

Author:
Wu, Ruijuan; Wu, Heng‐Hui; Wang, Cheng Lu
Source:
International journal of consumer studies 2021 v.45 no.3 pp. 364-378
ISSN:
1470-6423
Subject:
disease diagnosis,   etc   ; hybrids; information processing; journals; mathematical theory;     Show all 5 Subjects
Abstract:
... The hybrid review format (verbal reviews accompanied by pictures) is increasingly prevalent in online consumer reviews. However, the mechanism behind the superiority effect of hybrid reviews is still unclear. Unlike previous studies based on information processing theory that emphasize the imagery‐provoking ability of the verbal information, we contend that imagery in hybrid reviews is the informa ...
DOI:
10.1111/ijcs.12627

16. Multiple adsorption properties of aptamers on metal-organic frameworks for nucleic acid assay

Author:
Xie, Xiaoyu; Ke, Ruifang; Cheng, Chen; Wang, Yi-Hui; Song, Zhen; Zhang, Chang-Dong; Wang, Huai-Song
Source:
Biosensors & bioelectronics 2021 v.176 pp. 112896
ISSN:
0956-5663
Subject:
disease diagnosis,   etc   ; adsorption; biosensors; dyes; fluorescence; nucleic acids; oligonucleotides; pH;     Show all 8 Subjects
Abstract:
... Enrichment and detection of circulating free nucleic acids in biological samples have gained great attention for disease diagnosis or prognostic evaluation. Nanoscale metal-organic frameworks (NMOFs) have been used for aptamer-based nucleic acid sensing. In this work, different NMOFs, including ZIF-8, MIL-88, MIL-100, MIL-101, as well as Eu-TDA and Tb-TDA [prepared by the coordination of 2,2′-thio ...
DOI:
10.1016/j.bios.2020.112896

17. Mobile health applications for disease screening and treatment support in low-and middle-income countries: A narrative review

Author:
Osei, Ernest; Mashamba-Thompson, Tivani P.
Source:
Heliyon 2021 v.7 no.3 pp. e06639
ISSN:
2405-8440
Subject:
disease diagnosis,   etc   ; health services; mobile telephones; stakeholders; telemedicine;     Show all 5 Subjects
Abstract:
... The advances in mobile technologies and applications are driving the transformation in health services delivery globally. Mobile phone penetration is increasing exponentially in low-and middle-income countries, hence using mobile phones for healthcare services could reach more people in resource-limited settings than the traditional forms of healthcare provision. The review presents recent literat ...
DOI:
10.1016/j.heliyon.2021.e06639

18. IHEC_RAAC: a online platform for identifying human enzyme classes via reduced amino acid cluster strategy

Author:
Wang, Hao; Xi, Qilemuge; Liang, Pengfei; Zheng, Lei; Hong, Yan; Zuo, Yongchun
Source:
Amino acids 2021 v.53 no.2 pp. 239-251
ISSN:
0939-4451
Subject:
disease diagnosis,   etc   ; amino acids; data collection; enzymes; humans;     Show all 5 Subjects
Abstract:
... Enzymes have been proven to play considerable roles in disease diagnosis and biological functions. The feature extraction that truly reflects the intrinsic properties of protein is the most critical step for the automatic identification of enzymes. Although lots of feature extraction methods have been proposed, some challenges remain. In this study, we developed a predictor called IHEC_RAAC, which ...
DOI:
10.1007/s00726-021-02941-9

19. Fuel strand-powered self-propelled electrochemical DNA machine for enzyme-free and distinctly amplified detection of nucleic acid with tunable performance

Author:
Zhao, Zhen; Chen, Zhiqiang; Liu, Dengren; Wang, Li; Liu, Shufeng
Source:
Biosensors & bioelectronics 2021 v.171 pp. 112706
ISSN:
0956-5663
Subject:
disease diagnosis,   etc   ; DNA; biosensors; detection limit; electrochemistry; electrodes; medicine;     Show all 7 Subjects
Abstract:
... In this work, a self-propelled DNA machine was proposed for enzyme-free and ultrasensitive electrochemical detection of nucleic acid, which was based on a new strategy of the fuel strand-powered target recycling and successive proximity-based inter-strand displacement for distinct signal amplification. A three-strand duplex DNA (TSD) probe was immobilized onto electrode for target DNA recognition ...
DOI:
10.1016/j.bios.2020.112706

20. iCDA-CMG: identifying circRNA-disease associations by federating multi-similarity fusion and collective matrix completion

Author:
Xiao, Qiu; Zhong, Jiancheng; Tang, Xiwei; Luo, Jiawei
Source:
Molecular genetics and genomics 2021 v.296 no.1 pp. 223-233
ISSN:
1617-4615
Subject:
disease diagnosis,   etc   ; biomarkers; carcinogenesis; chemical bonding; genomics; humans; prediction; therapeutics;     Show all 8 Subjects
Abstract:
... Circular RNAs (circRNAs) are a special class of non-coding RNAs with covalently closed-loop structures. Studies prove that circRNAs perform critical roles in various biological processes, and the aberrant expression of circRNAs is closely related to tumorigenesis. Therefore, identifying potential circRNA-disease associations is beneficial to understand the pathogenesis of complex diseases at the c ...
DOI:
10.1007/s00438-020-01741-2