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1. Towards Engineering Broad-Spectrum Disease-Resistant Crops

Author:
Tian, Jingjing; Xu, Guoyong; Yuan, Meng
Source:
Trends in plant science 2020 v.25 no.5 pp. 424-427
ISSN:
1360-1385
Subject:
disease resistance,   etc   ; blight; crops; cultivars; engineering; genes; host-pathogen relationships; regulatory sequences; rice;     Show all 9 Subjects
Abstract:
... Crop pathologists and breeders are pursuing not only mechanistic understanding of plant–pathogen interactions but also engineering durable and broad-spectrum disease-resistant cultivars. Both goals are achieved in three recent studies by stacking editing of regulatory elements within promoters of susceptibility genes for blight disease in rice. ...
DOI:
10.1016/j.tplants.2020.02.012

2. A cocktail of polyclonal affinity enriched antibodies against melanoma mutations increases binding and inhibits tumor growth

Author:
Shukla, Girja S.; Sun, Yu-Jing; Pero, Stephanie C.; Krag, David N.
Source:
Journal of immunological methods 2020 v.478 pp. 112720
ISSN:
0022-1759
Subject:
disease resistance,   etc   ; amino acids; antigens; cytotoxicity; melanoma; mutation; neoplasm cells; patients; peptides; polyclonal antibodies; rabbits;     Show all 11 Subjects
Abstract:
... Antibodies that target a single tumor antigen fail to cure stage IV cancer patients due to tumor heterogeneity and variable expression of antigen. Tumor cells with insufficient binding of antibody will not undergo antibody induced cytotoxicity. We describe targeting multiple tumor-specific antigens that resulted in homogeneous dense binding to mouse melanoma cells and significant tumor growth inhi ...
DOI:
10.1016/j.jim.2019.112720

3. Genetic modification to improve disease resistance in crops

Author:
van Esse, H. Peter; Reuber, T. Lynne; van der Does, Dieuwertje
Source:
Thenew phytologist 2020 v.225 no.1 pp. 70-86
ISSN:
0028-646X
Subject:
disease resistance,   etc   ; agronomy; allergens; crops; ethics; food production; gene editing; genetically modified plants; plant pathogens;     Show all 9 Subjects
Abstract:
... Plant pathogens are a significant challenge in agriculture despite our best efforts to combat them. One of the most effective and sustainable ways to manage plant pathogens is to use genetic modification (GM) and genome editing, expanding the breeder's toolkit. For use in the field, these solutions must be efficacious, with no negative effect on plant agronomy, and deployed thoughtfully. They must ...
DOI:
10.1111/nph.15967
PubMed:
31135961
PubMed Central:
PMC6916320

4. Bacterial Effectors Induce Oligomerization of Immune Receptor ZAR1 In Vivo

Author:
Hu, Meijuan; Qi, Jinfeng; Bi, Guozhi; Zhou, Jian-Min
Source:
Molecular plant 2020 v.13 no.5 pp. 793-801
ISSN:
1674-2052
Subject:
disease resistance,   etc   ; Arabidopsis; Pseudomonas; Xanthomonas campestris pv. campestris; cell death; enzymes; immunity; immunologic receptors; oligomerization; pathogens; protoplasts;     Show all 11 Subjects
Abstract:
... Plants utilize nucleotide-binding, leucine-rich repeat receptors (NLRs) to detect pathogen effectors, leading to effector-triggered immunity. The NLR ZAR1 indirectly recognizes the Xanthomonas campestris pv. campestris effector AvrAC and Pseudomonas syringae effector HopZ1a by associating with closely related receptor-like cytoplasmic kinase subfamily XII-2 (RLCK XII-2) members RKS1 and ZED1, resp ...
DOI:
10.1016/j.molp.2020.03.004

5. Water environments: metal-tolerant and antibiotic-resistant bacteria

Author:
Squadrone, Stefania
Source:
Environmental monitoring and assessment 2020 v.192 no.4 pp. 238
ISSN:
0167-6369
Subject:
disease resistance,   etc   ; animal pathogens; antibiotic resistance; antibiotic resistance genes; antibiotics; bacteria; environmental health; freshwater; human health; metal tolerance; metals; risk;     Show all 12 Subjects
Abstract:
... The potential threat of both metals and antibiotics to the environment and human health has raised significant concerns in the last decade. Metal-resistant and antibiotic-resistant bacteria are found in most environments, including water, and the risk posed to humans and animals due to the spread of antibiotic-resistant bacteria and antibiotic-resistant genes in the environment is increasing. Bact ...
DOI:
10.1007/s10661-020-8191-8

6. Resistance to Fusarium head blight and mycotoxin accumulation among 129 wheat cultivars from different ecological regions in China

Author:
Yan, Z.; Zhang, H.; van der Lee, T.A.J.; Waalwijk, C.; van Diepeningen, A.D.; Deng, Y.; Feng, J.; Liu, T.; Chen, W.
Source:
World mycotoxin journal 2020 v.13 no.2 pp. 189-200
ISSN:
1875-0796
Subject:
disease resistance,   etc   ; Fusarium head blight; Triticum; cultivars; ecoregions; mass spectrometry; mycotoxins; plant breeding; wheat; China; Yangtze River;     Show all 11 Subjects
Abstract:
... A total of 129 wheat cultivars collected from local breeders in four ecological regions in China was evaluated for Fusarium head blight resistance after natural infection under epidemic conditions. The disease index was scored and seven toxins concentrations were determined by UPLC-MS/MS. The disease index ranged from 6.3 to 80.9% and a strong correlation was found between the regions from which t ...
DOI:
10.3920/WMJ2019.2501

7. Marker-Assisted Introgression of Quantitative Resistance Gene pi21 Confers Broad Spectrum Resistance to Rice Blast

Author:
Angeles-Shim, Rosalyn B.; Reyes, Vincent P.; del Valle, Marilyn M.; Lapis, Ruby S.; Shim, Junghyun; Sunohara, Hidehiko; Jena, Kshirod K.; Ashikari, Motoyuki; Doi, Kazuyuki
Source:
Rice science 2020 v.27 no.2 pp. 113-123
ISSN:
1672-6308
Subject:
disease resistance,   etc   ; amylose; backcrossing; blast disease; genetic background; genotyping; greenhouses; heading; introgression; leaves; panicles; parents; resistance genes; rice; Asia;     Show all 15 Subjects
Abstract:
... The quantitative resistance gene pi21 from Sensho was introgressed to an indica breeding line IR63307-4B-13-2, a pyramiding line IRBB4/5/13/21, and a tropical japonica line Kinandang Patong by marker-assisted backcrossing. A total of 192 improved lines at the BC₄F₃ and BC₄F₄ generations were developed and confirmed to have the gene introgression via genotyping using a pi21-specific InDel marker. T ...
DOI:
10.1016/j.rsci.2020.01.002

8. The evolution of resistance and tolerance as cancer defences

Author:
Thomas, Frédéric; Giraudeau, Mathieu; Gouzerh, Flora; Boutry, Justine; Renaud, François; Pujol, Pascal; Tasiemski, Aurélie; Bernex, Florence; Maraver, Antonio; Bousquet, Emilie; Dormont, Laurent; Osterkamp, Jens; Roche, Benjamin; Hamede, Rodrigo; Ujvari, Beata
Source:
Parasitology 2020 v.147 no.3 pp. 255-262
ISSN:
1469-8161
Subject:
disease resistance,   etc   ; Animalia; cachexia; cell proliferation; death; evolution; host-parasite relationships; metastasis; neoplasm progression; neoplasms; resistance mechanisms; secondary infection;     Show all 12 Subjects
Abstract:
... Although there is a plethora of cancer associated-factors that can ultimately culminate in death (cachexia, organ impairment, metastases, opportunistic infections, etc.), the focal element of every terminal malignancy is the failure of our natural defences to control unlimited cell proliferation. The reasons why our defences apparently lack efficiency is a complex question, potentially indicating ...
DOI:
10.1017/S0031182019001501

9. Genome-Wide Identification of lncRNAs and Analysis of ceRNA Networks During Tomato Resistance to Phytophthora infestans

Author:
Cui, Jun; Jiang, Ning; Hou, Xinxin; Wu, Sihan; Zhang, Qiang; Meng, Jun; Luan, Yushi
Source:
Phytopathology 2020 v.110 no.2 pp. 456-464
ISSN:
0031-949X
Subject:
disease resistance,   etc   ; Phytophthora infestans; Solanum lycopersicum; gene expression regulation; genes; microRNA; non-coding RNA; tomatoes; transcription factors;     Show all 9 Subjects
Abstract:
... Our previous studies have revealed the function of long noncoding RNAs (lncRNAs) and microRNAs (miRNAs) in tomato in response to Phytophthora infestans infection. However, the interaction relationships between lncRNAs and miRNAs during tomato resistance to P. infestans infection are unknown. In this study, 9,011 lncRNAs were identified from tomato plants, including 115 upregulated and 81 downregul ...
DOI:
10.1094/PHYTO-04-19-0137-R

10. Microbial Control of Intestinal Homeostasis via Enteroendocrine Cell Innate Immune Signaling

Author:
Watnick, Paula I.; Jugder, Bat-Erdene
Source:
Trends in microbiology 2020 v.28 no.2 pp. 141-149
ISSN:
0966-842X
Subject:
disease resistance,   etc   ; Drosophila melanogaster; G-protein coupled receptors; homeostasis; innate immunity; intestinal microorganisms; intestinal mucosa; metabolism; pathogens; signal transduction;     Show all 10 Subjects
Abstract:
... A community of commensal microbes, known as the intestinal microbiota, resides within the gastrointestinal tract of animals and plays a role in maintenance of host metabolic homeostasis and resistance to pathogen invasion. Enteroendocrine cells, which are relatively rare in the intestinal epithelium, have evolved to sense and respond to these commensal microbes. Specifically, they express G-protei ...
DOI:
10.1016/j.tim.2019.09.005
PubMed:
31699645
PubMed Central:
PMC6980660

11. Nanovehicles for Plant Modifications towards Pest- and Disease-Resistance Traits

Author:
Kumar, Sandeep; Nehra, Monika; Dilbaghi, Neeraj; Marrazza, Giovanna; Tuteja, Satish K.; Kim, Ki-Hyun
Source:
Trends in plant science 2020 v.25 no.2 pp. 198-212
ISSN:
1360-1385
Subject:
disease resistance,   etc   ; cell walls; gene transfer; genetic traits; nanoparticles; nutrient content; organelles; pathogens; pest resistance; pests; toxicity;     Show all 11 Subjects
Abstract:
... In agriculture, plant transformation is a versatile platform for crop improvement with the aim of increased pest resistance and an improved nutrient profile. Nanotechnology can overcome several challenges that face conventional methods of gene delivery. Specifically, nanomaterials offer an optimal platform for biomolecule delivery with unique physiochemical properties as well as the ability to tra ...
DOI:
10.1016/j.tplants.2019.10.007

12. Natural Host-Induced Gene Silencing Offers New Opportunities to Engineer Disease Resistance

Author:
Hou, Yingnan; Ma, Wenbo
Source:
Trends in microbiology 2020 v.28 no.2 pp. 109-117
ISSN:
0966-842X
Subject:
disease resistance,   etc   ; Phytophthora; RNA; RNA interference; anti-infective agents; engineering; fungi; gene expression; genes; host plants; pathogens;     Show all 11 Subjects
Abstract:
... RNA silencing is an essential gene-regulation mechanism in eukaryotic organisms. Guided by small RNAs (sRNAs) of 20–25 nt in length, RNA silencing broadly governs a wide range of biological processes. In addition to regulating endogenous gene expression and inhibiting viral infection, accumulating evidence suggests that sRNAs can also function as antimicrobial agents against nonviral pathogens and ...
DOI:
10.1016/j.tim.2019.08.009

13. Translational Regulation of Metabolic Dynamics during Effector-Triggered Immunity

Author:
Yoo, Heejin; Greene, George H.; Yuan, Meng; Xu, Guoyong; Burton, Derek; Liu, Lijing; Marqués, Jorge; Dong, Xinnian
Source:
Molecular plant 2020 v.13 no.1 pp. 88-98
ISSN:
1674-2052
Subject:
disease resistance,   etc   ; Arabidopsis; amino acids; enzymes; gene expression; genes; immune response; lipid metabolism; phenylpropanoids; ribosomes; sphingolipids; transcription (genetics); translation (genetics);     Show all 13 Subjects
Abstract:
... Recent studies have shown that global translational reprogramming is an early activation event in pattern-triggered immunity, when plants recognize microbe-associated molecular patterns. However, it is not fully known whether translational regulation also occurs in subsequent immune responses, such as effector-triggered immunity (ETI). In this study, we performed genome-wide ribosome profiling in ...
DOI:
10.1016/j.molp.2019.09.009
PubMed:
31568832
PubMed Central:
PMC6946852

14. A novel technique for retrospective genetic analysis of the response to vaccination or infection using cell-free DNA from archived sheep serum and plasma

Author:
Hanks, Eve; Todd, Helen; Palarea-Albaladejo, Javier; McNeilly, Tom N.; Britton, Collette; Ballingall, Keith T.
Source:
Veterinary research 2020 v.51 no.1 pp. 9
ISSN:
1297-9716
Subject:
disease resistance,   etc   ; DNA; Haemonchus contortus; Merino; alleles; blood serum; field experimentation; genetic analysis; genetic variation; genotype; loci; major histocompatibility complex; retrospective studies; sheep; vaccination; vaccines; Australia;     Show all 17 Subjects
Abstract:
... Genetic variation is associated with differences in disease resistance and susceptibility among individuals within a population. To date, molecular genetic analyses of host responses have relied on extraction of genomic DNA from whole blood or tissue samples. However, such samples are not routinely collected during large-scale field studies. We demonstrate that cell-free genomic DNA (cfDNA) may be ...
DOI:
10.1186/s13567-020-0737-9
PubMed:
32024546
PubMed Central:
PMC7003321

15. Changes in intestinal microbiota and disease resistance following dietary postbiotic supplementation in rainbow trout (Oncorhynchus mykiss)

Author:
Pérez-Sánchez, Tania; Mora-Sánchez, Brenda; Vargas, Augusto; Balcázar, José Luis
Source:
Microbial pathogenesis 2020 v.142 pp. 104060
ISSN:
0882-4010
Subject:
disease resistance,   etc   ; Lactococcus garvieae; Oncorhynchus mykiss; bacterial communities; community structure; dietary supplements; fish; fish diseases; foods; intestinal microorganisms; intestines; lactic acid bacteria;     Show all 12 Subjects
Abstract:
... This experimental study was aimed to investigate whether the dietary supplementation of a postbiotic obtained as a food product fermented with two lactic acid bacteria could induce changes in the intestinal microbiota and prevent the development of Lactococcus garvieae infection in rainbow trout (Oncorhynchus mykiss). After 30 days of dietary postbiotic supplementation, bacterial community composi ...
DOI:
10.1016/j.micpath.2020.104060

16. Plant surface metabolites as potent antifungal agents

Author:
Dubey, Olga; Dubey, Sylvain; Schnee, Sylvain; Glauser, Gaëtan; Nawrath, Christiane; Gindro, Katia; Farmer, Edward E.
Source:
Plant physiology and biochemistry 2020 v.150 pp. 39-48
ISSN:
0981-9428
Subject:
disease resistance,   etc   ; Arabidopsis thaliana; Botrytis cinerea; adhesion; antifungal agents; cotyledons; fungi; genes; glucosinolates; hyphae; jasmonic acid; metabolites; mutants; pathogens; permeability; polyunsaturated fatty acids; seedlings;     Show all 17 Subjects
Abstract:
... Triunsaturated fatty acids are substrates for the synthesis of the defense hormone jasmonate which plays roles in resistance to numerous fungal pathogens. However, relatively little is known about other potential roles of di-unsaturated and triunsaturated fatty acids in resistance to fungal pathogens – in particular those that can attack plants at the seedling stage. We examined the roles of polyu ...
DOI:
10.1016/j.plaphy.2020.02.026

17. CRISPR/Cas9 to generate plant immunity against pathogen

Author:
Zaynab, Madiha; Sharif, Yasir; Fatima, Mahpara; Afzal, Muhammad Zohaib; Aslam, Mehtab Muhammad; Raza, Muhammad Fahad; Anwar, Muhammad; Raza, Muhammad Ammar; Sajjad, Nelam; Yang, Xuewei; Li, Shuangfei
Source:
Microbial pathogenesis 2020 v.141 pp. 103996
ISSN:
0882-4010
Subject:
disease resistance,   etc   ; CRISPR-Cas systems; DNA; RNA; bacteria; crops; engineering; fungi; gene editing; host-pathogen relationships; immunity; insects; nucleases; pathogens; transcription (genetics); viruses; zinc finger motif;     Show all 17 Subjects
Abstract:
... Different types of molecular approaches have been used for improving resistance against pathogens to secure food. Efficient and advanced genome editing tool as paralleled to earlier techniques like Zinc Finger Nuclease (ZFN), transcription activator-like effector nucleases (TALENs), and Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR). The approach of CRISPR/Cas9 has updated our ...
DOI:
10.1016/j.micpath.2020.103996

18. HOS15 and HDA9 negatively regulate immunity through histone deacetylation of intracellular immune receptor NLR genes in Arabidopsis

Author:
Yang, Leiyun; Chen, Xiangsong; Wang, Zhixue; Sun, Qi; Hong, Anna; Zhang, Aiqin; Zhong, Xuehua; Hua, Jian
Source:
Thenew phytologist 2020 v.226 no.2 pp. 507-522
ISSN:
0028-646X
Subject:
disease resistance,   etc   ; Arabidopsis thaliana; acetylation; epigenetics; gene expression; genes; histone deacetylase; histones; immune response; immunologic receptors; leucine; loci; loss-of-function mutation; pathogens;     Show all 14 Subjects
Abstract:
... Plant immune responses need to be tightly controlled for growth–defense balance. The mechanism underlying this tight control is not fully understood. Here we identify epigenetic regulation of nucleotide‐binding leucine rich repeat or Nod‐Like Receptor (NLR) genes as an important mechanism for immune responses. Through a sensitized genetic screen and molecular studies, we identified and characteriz ...
DOI:
10.1111/nph.16380
PubMed:
31854111
PubMed Central:
PMC7080574

19. ScPNP-A, a plant natriuretic peptide from Stellera chamaejasme, confers multiple stress tolerances in Arabidopsis

Author:
Liu, Xin; Guan, Huirui; Wang, Tianshu; Meng, Dian; Yang, Youfeng; Dai, Jiakun; Fan, Na; Guo, Bin; Fu, Yanping; He, Wei; Wei, Yahui
Source:
Plant physiology and biochemistry 2020 v.149 pp. 132-143
ISSN:
0981-9428
Subject:
disease resistance,   etc   ; Arabidopsis thaliana; Stellera chamaejasme; abscisic acid; biosynthesis; biotic stress; cold stress; cold tolerance; drought; gene overexpression; genes; natriuretic peptides; pathogens; plant response; signal transduction; stomata;     Show all 16 Subjects
Abstract:
... As a class of peptide hormone, plant natriuretic peptides (PNPs) play an important role in maintaining water and salt balance in plants, as well as in the physiological processes of biotic stress and pathogen resistance. However, in plants, except for some PNPs, such as the Arabidopsis thaliana PNP-A (AtPNP-A), of which the function has not yet been thoroughly revealed, few PNPs in other plants ha ...
DOI:
10.1016/j.plaphy.2020.02.005

20. Analysis of leaf microbiome composition of near‐isogenic maize lines differing in broad‐spectrum disease resistance

Author:
Wagner, Maggie R.; Busby, Posy E.; Balint‐Kurti, Peter
Source:
Thenew phytologist 2020 v.225 no.5 pp. 2152-2165
ISSN:
0028-646X
Subject:
disease resistance,   etc   ; Zea mays; alleles; community structure; corn; fungi; genotype; inbred lines; introgression; leaves; microbiome; pathogens; pleiotropy; quantitative trait loci; symbionts;     Show all 15 Subjects
Abstract:
... Plant genotype strongly affects disease resistance, and also influences the composition of the leaf microbiome. However, these processes have not been studied and linked in the microevolutionary context of breeding for improved disease resistance. We hypothesised that broad‐spectrum disease resistance alleles also affect colonisation by nonpathogenic symbionts. Quantitative trait loci (QTL) confer ...
DOI:
10.1111/nph.16284