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diseaseseverity, etc ; immune response; pathogens; viruses; Show all 4 Subjects
Abstract:
... Viral infections are very common, and in most cases, the virus is well controlled and eliminated by the immune system. Nevertheless, in some cases, damage of the host tissue inflicted by the virus itself or by the elicited immune response may result in severe disease courses. Thus, regulatory mechanisms are necessary to control virus‐induced and immune pathology. This ensures immune responses are ...
diseaseseverity, etc ; Mycosphaerella graminicola; cultivars; fungicides; wheat; yields; Denmark; Show all 7 Subjects
Abstract:
... Septoria tritici blotch (STB) is among the most devastating diseases in European wheat production. In recent years, there has been increased interest in using cultivar mixtures as part of an integrated control strategy against diseases. This study investigated different cultivar mixtures for their ability to control STB across three years and at seven trial sites in Denmark with a range of fungici ...
diseaseseverity, etc ; phenotype; plant pathology; psychophysics; tropical plants; wheat; Show all 6 Subjects
Abstract:
... Plant disease quantification, mainly the intensity of disease symptoms on individual units (severity), is the basis for a plethora of research and applied purposes in plant pathology and related disciplines. These include evaluating treatment effect, monitoring epidemics, understanding yield loss, and phenotyping for host resistance. Although sensor technology has been available to measure disease ...
diseaseseverity, etc ; childhood obesity; fatty liver; histology; regression analysis; retrospective studies; Show all 6 Subjects
Abstract:
... Background: Alternative BMI metrics are superior to BMI z score (BMIz) in tracking obesity but have not been evaluated in patients with nonalcoholic fatty liver disease (NAFLD). Our objective was to evaluate whether BMI-adjusted z score (BMIaz) or BMI expressed as a percentage of the 95th percentile (%BMIp95) are better predictors of degree of alanine aminotransferase (ALT) elevation, a surrogate ...
diseaseseverity, etc ; COVID-19 infection; electromyography; nerve tissue; prognosis; tibia; variance; Show all 7 Subjects
Abstract:
... Patients with Coronavirus-2019 (COVID-19) manifest many neuromuscular complications. We evaluated the correlations between electromyography and nerve conduction measurements among COVID-19 patients and the severity of the initial infection, as well as the rehabilitation outcomes, and searched for the factors which best predict the rehabilitation outcomes. A total of 19 COVID-19 patients (16 men; m ...
diseaseseverity, etc ; Orthomyxoviridae; influenza; influenza vaccination; mixed infection; monitoring; viruses; Germany; Show all 8 Subjects
Abstract:
... Influenza virus (IV) coinfection, i.e., simultaneous infection with IV and other viruses, is a common occurrence in humans. However, little is known about the incidence and clinical impact of coinfection with two different IV subtypes or lineages (“dual infections”). We report the incidence, standardized disease severity, and follow-up of IV dual infections from a hospital-based digital surveillan ...
diseaseseverity, etc ; biomarkers; clinical examination; diarrhea; hospitals; inflammation; neutrophils; retrospective studies; Show all 8 Subjects
Abstract:
... OBJECTIVES: To document the neutrophil to lymphocyte ratio (NLR) values in systemic inflammatory response syndrome positive (SIRS+) and negative (SIRS–) puppies presenting with acute diarrhea (AD). To determine whether the calculated canine acute diarrhea severity index (CADSI) score was associated with NLR. Also, to investigate the prognostic value of NLR in puppies with acute diarrhea. DESIGN: R ...
diseaseseverity, etc ; DNA; Salmonella; death; detection limit; foodborne bacterial pathogens; genes; liquids; Show all 8 Subjects
Abstract:
... Salmonella is a common foodborne bacterial pathogen that leads to severe illness or even death. The recommended method for Salmonella detection relies on the culture and has a long turnaround time of up to ∼1 week. In this study, we have developed a molecular assay that detects Salmonella in food by targeting the invA gene using loop-mediated isothermal amplification (LAMP) and lateral flow assay ...
diseaseseverity, etc ; Brassicaceae; Sclerotinia sclerotiorum; leaves; lettuce; pathogens; plant pathology; potatoes; tobacco; tomatoes; Show all 10 Subjects
Abstract:
... Sclerotinia sclerotiorum is a geographically cosmopolitan species with a wide ecological distribution, although it is most common in temperate regions. More than 400 plant species are susceptible to this pathogen, including most vegetables (e.g., potato, tomato, lettuce, and crucifers), tobacco, and major crops. This study aimed to develop and validate a diagrammatic scale to aid in the visual ass ...
diseaseseverity, etc ; disease progression; drugs; liver; liver diseases; peptides; pharmacokinetics; protein content; proteomics; Show all 9 Subjects
Abstract:
... Model-based assessment of drug pharmacokinetics in liver disease requires quantification of abundance and disease-related changes in hepatic enzymes and transporters. This study aimed to assess performance of three label-free methods [high N (HiN), intensity-based absolute quantification (iBAQ) and total protein approach (TPA)] against QconCAT-based targeted data in healthy and diseased (cancer an ...
diseaseseverity, etc ; Severe acute respiratory syndrome coronavirus 2; biosensors; fluorescence; mutants; rapid methods; Show all 6 Subjects
Abstract:
... The increasing prevalence of SARS-CoV-2 variants with spike mutations has raised concerns owing to higher transmission rates, disease severity, and escape from neutralizing antibodies. Rapid and accurate detection of SARS-CoV-2 variants provides crucial information concerning the outbreaks of SARS-CoV-2 variants and possible lines of transmission. This information is vital for infection prevention ...
diseaseseverity, etc ; chromosomes; corn; disease resistance; haplotypes; phenotypic variation; prediction; progeny; substitution lines; viruses; Show all 10 Subjects
Abstract:
... Maize rough dwarf disease (MRDD) is caused by a virus and seriously affects maize quality and yield worldwide. MRDD can be most effectively controlled with disease-resistant hybrids of corn. Here, MRDD-resistant (Qi319) and -susceptible (Ye478) parental inbred maize lines and their 314 recombinant inbred lines (RILs) that were derived from a cross between them were evaluated across three environme ...
diseaseseverity, etc ; Orthohantavirus; antagonism; fever; host specificity; humans; innate immunity; insectivores; molecular biology; rodents; Show all 10 Subjects
Abstract:
... The genus Orthohantavirus (family Hantaviridae, order Bunyavirales) consists of numerous genetic and pathologically distinct viral species found within rodent and mammalian insectivore populations world-wide. Although reservoir hosts experience persistent asymptomatic infection, numerous rodent-borne orthohantaviruses cause severe disease when transmitted to humans, with case-fatality rates up to ...
diseaseseverity, etc ; arthritis; bone marrow; epigenetics; inflammation; innate immunity; interleukin-1; periodontitis; phenotype; progeny; Show all 10 Subjects
Abstract:
... Bone marrow (BM)-mediated trained innate immunity (TII) is a state of heightened immune responsiveness of hematopoietic stem and progenitor cells (HSPC) and their myeloid progeny. We show here that maladaptive BM-mediated TII underlies inflammatory comorbidities, as exemplified by the periodontitis-arthritis axis. Experimental-periodontitis-related systemic inflammation in mice induced epigenetic ...
diseaseseverity, etc ; adrenal cortex hormones; asthma; blood serum; calcium; clinical nutrition; lung function; phosphorus; risk; Show all 9 Subjects
Abstract:
... Asthma prevalence has increased significantly since the 1960s. Increased airway hyperresponsiveness, decreased pulmonary function, poor asthma management, and steroid resistance have all been linked to vitamin D insufficiency. In addition, treatment with oral corticosteroids increases the risk of vitamin D deficiency. We studied patients with asthma regarding their vitamin D status and its associa ...
diseaseseverity, etc ; Severe acute respiratory syndrome coronavirus 2; glycoproteins; humans; influenza; monitoring; pandemic; pathogenesis; viruses; Show all 9 Subjects
Abstract:
... This article aims to review all currently known interactions between animal and human coronaviruses and their cellular receptors. Over the past 20 years, three novel coronaviruses have emerged that have caused severe disease in humans, including SARS-CoV-2 (severe acute respiratory syndrome virus 2); therefore, a deeper understanding of coronavirus host–cell interactions is essential. Receptor-bin ...
diseaseseverity, etc ; Ceratocystis paradoxa; Phytophthora cinnamomi; Talaromyces funiculosus; heart rot; phosphonates; pineapples; plant pathology; potassium; Show all 9 Subjects
Abstract:
... Base rot, caused by Ceratocystis paradoxa, can be a severe disease of pineapple planting material and can result in poor establishment of plants. Pre-plant dipping of pineapple crowns in potassium phosphonate is used to control Phytophthora cinnamomi root and heart rot and was tested for efficacy against base rot in this study. Dipping crowns in 0.5% potassium phosphonate for 2 min significantly r ...
... Old–world orthohantaviruses cause hemorrhagic fever with renal syndrome (HFRS), characterized by acute kidney injury (AKI) with transient proteinuria. It seems plausible that proteinuria during acute HFRS is mediated by the disruption of the glomerular filtration barrier (GFB) due to vascular leakage, a hallmark of orthohantavirus–caused diseases. However, direct infection of endothelial cells by ...
... The clinical expression of zoonotic cutaneous leishmaniasis (ZCL) caused by Leishmania (L.) major parasites has a broad spectrum ranging from asymptomatic infection to self-limited cutaneous sores or severe disease. In concert with the host immune responses, the vector variability and the number of bites, genetic variation between L. major isolates might impact on the clinical output of the diseas ...
diseaseseverity, etc ; alleles; clinical nutrition; confidence interval; cross-sectional studies; genotyping; lifestyle; risk; sclerosis; tea; Italy; Show all 11 Subjects
Abstract:
... The association between lifestyle factors and Multiple Sclerosis (MS) disease severity and progression has been investigated to a lesser extent compared with susceptibility to the disease. We aimed to assess the impact of lifetime coffee and tea consumption on MS severity. Design: cross-sectional study. Two hundred and eight patients (139 females and 69 males) consecutively recruited at the Depart ...