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1. Murmur intensity in adult dogs with pulmonic and subaortic stenosis reflects disease severity

Author:
Caivano, D.; Dickson, D.; Martin, M.; Rishniw, M.
Source:
Thejournal of small animal practice 2018 v.59 no.3 pp. 161-166
ISSN:
0022-4510
Subject:
disease severity,   etc   ; adults; dogs; echocardiography;     Show all 4 Subjects
Abstract:
... OBJECTIVES: The aims of this study were to determine whether murmur intensity in adult dogs with pulmonic stenosis or subaortic stenosis reflects echocardiographic disease severity and to determine whether a six‐level murmur grading scheme provides clinical advantages over a four‐level scheme. MATERIALS AND METHODS: In this retrospective multi‐investigator study on adult dogs with pulmonic stenosi ...
DOI:
10.1111/jsap.12760

2. CD200 in asthma

Author:
Lauzon-Joset, Jean-François; Marsolais, David; Tardif-Pellerin, Éliane; Patoine, Dany; Bissonnette, Elyse Y.
Source:
The international journal of biochemistry & cell biology 2019 v.112 pp. 141-144
ISSN:
1357-2725
Subject:
disease severity,   etc   ; asthma; epithelial cells; gas exchange; hypersensitivity; immunomodulation; leukocytes; lungs; models; receptors;     Show all 10 Subjects
Abstract:
... Constant exposure to foreign particles in the airways requires tight immune regulation in order to maintain sufficient anti-microbial defences, while preventing immunopathological responses that could impair gas exchange. Dysregulation of immunoregulatory pathways has been associated with asthma and allergy. This review will focus on the CD200 regulatory pathway and its role in the asthmatic casca ...
DOI:
10.1016/j.biocel.2019.05.003

3. Ceftaroline fosamil therapy in patients with acute bacterial skin and skin-structure infections with systemic inflammatory signs: A retrospective dose comparison across three pivotal trials

Author:
Corey, G. Ralph; Wilcox, Mark H.; Gonzalez, Jesus; Jandourek, Alena; Wilson, David J.; Friedland, H. David; Das, Shampa; Iaconis, Joseph; Dryden, Matthew
Source:
International journal of antimicrobial agents 2019 v.53 no.6 pp. 830-837
ISSN:
0924-8579
Subject:
disease severity,   etc   ; anti-infective agents; inflammation; minimum inhibitory concentration; pathogens; patients; pharmacokinetics; sepsis (infection); therapeutics;     Show all 9 Subjects
Abstract:
... This post-hoc analysis compared the pharmacokinetics and clinical outcomes of ceftaroline fosamil 600 mg every 12 (q12h) versus every 8 hours (q8h) in patients with acute bacterial skin and skin-structure infection (ABSSSI) and signs of sepsis. Clinical outcomes at test-of-cure in patients with ABSSSI and systemic inflammatory signs/systemic inflammatory response syndrome (SIRS) as well as ceftaro ...
DOI:
10.1016/j.ijantimicag.2019.01.016

4. Importance of the 3′-Terminal Nucleotide of the Forward Primer for Nucleoprotein Gene Detection of Viral Hemorrhagic Septicemia Virus by Conventional Reverse-Transcription PCR

Author:
Kim, Hyoung Jun
Source:
Indian journal of microbiology 2019 v.59 no.2 pp. 234-236
ISSN:
0046-8991
Subject:
disease severity,   etc   ; Viral hemorrhagic septicemia virus; farmed fish; genes; genotyping; nucleoproteins; reverse transcriptase polymerase chain reaction;     Show all 7 Subjects
Abstract:
... Viral hemorrhagic septicemia virus (VHSV), causing severe diseases in farmed fish, is detected and genotyped using conventional reverse-transcription PCR (cRT-PCR) targeting the nucleoprotein gene with corresponding VN F (forward) and VN R (reverse) primers. However, these primers have low sensitivity to VHSV subtype IVa; I investigated the cause for the poor cRT-PCR performance using various prim ...
DOI:
10.1007/s12088-019-00791-4

5. Rab18: new insights into the function of an essential protein

Author:
Dejgaard, Selma Yilmaz; Presley, John F.
Source:
Cellular and molecular life sciences 2019 v.76 no.10 pp. 1935-1945
ISSN:
1420-682X
Subject:
disease severity,   etc   ; ancestry; autophagy; droplets; endoplasmic reticulum; humans; lipids; mechanism of action; proteins;     Show all 9 Subjects
Abstract:
... Rab18 is one of the small number of conserved Rab proteins which have been traced to the last eukaryotic common ancestor. It is found in organisms ranging from humans to trypanosomes, and localizes to multiple organelles, including most notably endoplasmic reticulum and lipid droplets. In humans, absence of Rab18 leads to a severe illness known as Warburg-Micro syndrome. Despite this evidence that ...
DOI:
10.1007/s00018-019-03050-3

6. Assessment of the interaction between the spatial organization of citrus trees populations in cocoa agroforests and Phytophthora foot rot disease of citrus severity

Author:
Akoutou Mvondo, Etienne; Ndo, Eunice Golda Danièle; Ngo Bieng, Marie-Ange; Ambang, Zachée; Bella Manga,; Cilas, Christian; Tsouga Manga, Milie Lionnelle; Bidzanga Nomo, Lucien
Source:
Agroforestry systems 2019 v.93 no.2 pp. 493-502
ISSN:
0167-4366
Subject:
disease severity,   etc   ; Citrus; Phytophthora; agroforestry; biodiversity; forests; humid zones; leaves; pest control; trees; wet season; Cameroon;     Show all 12 Subjects
Abstract:
... Complex agroforestry systems are known to be less conducive to the dispersion of plant pathogenic germs. These systems, which combine many species components provide a means of improving environmental and regulatory mechanisms of disease. The spatial structure, which is a basic characteristic of these systems, has often been indicated as one of the ecological pest control tool. This study was cond ...
DOI:
10.1007/s10457-017-0140-3

7. The RNase PARN Controls the Levels of Specific miRNAs that Contribute to p53 Regulation

Author:
Shukla, Siddharth; Bjerke, Glen A.; Muhlrad, Denise; Yi, Rui; Parker, Roy
Source:
Molecular cell 2019 v.73 no.6 pp. 1204-1216.e4
ISSN:
1097-2765
Subject:
disease severity,   etc   ; genetic disorders; humans; microRNA; non-coding RNA; patients; ribonucleases; telomerase;     Show all 8 Subjects
Abstract:
... PARN loss-of-function mutations cause a severe form of the hereditary disease dyskeratosis congenita (DC). PARN deficiency affects the stability of non-coding RNAs such as human telomerase RNA (hTR), but these effects do not explain the severe disease in patients. We demonstrate that PARN deficiency affects the levels of numerous miRNAs in human cells. PARN regulates miRNA levels by stabilizing ei ...
DOI:
10.1016/j.molcel.2019.01.010

8. Modulation of nuclear receptor function: Targeting the protein-DNA interface

Author:
Veras Ribeiro Filho, Helder; Tambones, Izabella Luisa; Mariano Gonçalves Dias, Marieli; Bernardi Videira, Natalia; Bruder, Marjorie; Amorim Amato, Angélica; Migliorini Figueira, Ana Carolina
Source:
Molecular and cellular endocrinology 2019 v.484 pp. 1-14
ISSN:
0303-7207
Subject:
disease severity,   etc   ; DNA; DNA-binding domains; breast neoplasms; ligands; prostatic neoplasms; receptors; transcription factors;     Show all 8 Subjects
Abstract:
... Nuclear receptors (NRs) are a superfamily of ligand-dependent transcription factors that modulate several biological processes. Traditionally, modulation of NRs has been focused on the development of ligands that recognize and bind to the ligand binding domain (LBD), resulting in activation or repression of transcription through the recruitment of coregulators. However, for more severe diseases, s ...
DOI:
10.1016/j.mce.2019.01.023

9. Comparison of closed root planing with versus without concurrent doxycycline hyclate or clindamycin hydrochloride gel application for the treatment of periodontal disease in dogs

Author:
Martel, Django P.; Fox, Philip R.; Lamb, Kenneth E.; Carmichael, Daniel T.
Source:
Journal of the American Veterinary Medical Association 2019 v.254 no.3 pp. 373-379
ISSN:
0003-1488
Subject:
disease severity,   etc   ; clindamycin; clinical trials; dog diseases; dogs; doxycycline; gingivitis; hydrogels; teeth;     Show all 9 Subjects
Abstract:
... OBJECTIVE To compare improvements in values for periodontal disease indices in dogs following treatment with closed root planing (CRP) alone, CRP with concurrent 8.5% doxycycline hyclate gel application, and CRP with concurrent 2% clindamycin hydrochloride reverse-polymer hydrogel application. DESIGN Randomized, blinded, controlled clinical trial. ANIMALS 34 client-owned dogs with periodontal pock ...
DOI:
10.2460/javma.254.3.373

10. Accuracy and efficiency of assessments of cassava brown leaf spot aided by standard area diagram sets based on whole compound leaves or single central leaflets

Author:
Lima Filho, Francisco Alberto Sousa; Leite, Íris Carolina Henrique Lima; Capucho, Alexandre Sandri; Michereff, Sami Jorge; Freitas-Lopes, Rejane Livramento; Lopes, Ueder Pedro
Source:
European journal of plant pathology 2019 v.153 no.2 pp. 627-638
ISSN:
0929-1873
Subject:
disease severity,   etc   ; Passalora; cassava; germplasm conservation; image analysis; leaf spot; leaves; statistics;     Show all 8 Subjects
Abstract:
... This study aimed to develop, evaluate and compare standard area diagram sets (SADs) based on whole compound leaves or single central leaflets of cassava as aids to estimate the severity of brown leaf spot (BLS), caused by Passalora henningsii. The proposed SADs illustrated either compound leaves or central leaflets with eight disease severities ranging from 0.1 to 24%. The SADs were validated by e ...
DOI:
10.1007/s10658-018-1586-5

11. Heart-fatty acid binding protein in dogs with degenerative valvular disease and dilated cardiomyopathy

Author:
Lam, C.; Casamian-Sorrosal, D.; Monteith, G.; Fonfara, S.
Source:
The veterinary journal 2019 v.244 pp. 16-22
ISSN:
1090-0233
Subject:
disease severity,   etc   ; binding proteins; blood serum; brain; cardiomyopathy; dogs; natriuretic peptides; prediction; troponin I;     Show all 9 Subjects
Abstract:
... The study objective was to investigate heart-fatty acid binding protein (HFABP) concentrations in dogs with degenerative valvular disease (MVD) and dilated cardiomyopathy (DCM), and its potential as a prognostic factor. Plasma HFABP, N-terminal pro brain natriuretic peptide (NTproBNP) and serum cardiac troponin I (cTnI) levels were measured in 21 control dogs, 23 dogs with MVD and 13 dogs with DCM ...
DOI:
10.1016/j.tvjl.2018.11.017

12. PD2SE-Net: Computer-assisted plant disease diagnosis and severity estimation network

Author:
Liang, Qiaokang; Xiang, Shao; Hu, Yucheng; Coppola, Gianmarc; Zhang, Dan; Sun, Wei
Source:
Computers and electronics in agriculture 2019 v.157 pp. 518-529
ISSN:
0168-1699
Subject:
disease severity,   etc   ; disease diagnosis; leaves; neural networks; plant diseases and disorders;     Show all 5 Subjects
Abstract:
... The plant disease diagnosis and severity estimation are a very challenging research field in the agriculture sector. In this work, we present a robust image-based Plant Disease Diagnosis and Severity Estimation Network (PD2SE-Net), which contains a residual structure and shuffle units. The aim of this paper is to design a more excellent and practical diagnosis system for plant diseases. The common ...
DOI:
10.1016/j.compag.2019.01.034

13. Standard area diagrams to aid assessments of the severity of blight leaf spot symptoms on cassava leaves

Author:
Leite, Iris Carolina Henrique Lima; Filho, Francisco Alberto Sousa Lima; Freitas-Lopes, Rajane Livramento; Michereff, Sami Jorge; Capucho, Alexandre Sandri; Lopes, Ueder Pedro
Source:
Journal of plant pathology 2019 v.101 no.1 pp. 155-160
ISSN:
1125-4653
Subject:
disease severity,   etc   ; Passalora; breeding; cassava; fungicides; leaf spot; leaves; pathotypes; screening;     Show all 9 Subjects
Abstract:
... A standard area diagram (SAD) set to assess the severity of blight leaf spot (BliLS) caused by Passalora vicosae on cassava leaves was developed and validated. The proposed SAD set includes diagrams illustrating six leaves with different severities of blight leaf spot (5, 10, 20, 30, 40 and 50%). The SAD set was validated by ten raters with no previous experience in disease assessment. Lin’s conco ...

14. Up-regulated expression of spherical body protein 2 truncated copy 11 in Babesia bovis is associated with reduced cytoadhesion to vascular endothelial cells

Author:
Gallego-Lopez, Gina M.; Lau, Audrey O.T.; O'Connor, Roberta M.; Ueti, Massaro W.; Cooke, Brian M.; Laughery, Jacob M.; Graça, Telmo; Madsen-Bouterse, Sally A.; Oldiges, Daiane P.; Allred, David R.; Suarez, Carlos E.
Source:
International journal for parasitology 2019 v.49 no.2 pp. 127-137
ISSN:
0020-7519
Subject:
disease severity,   etc   ; Babesia bovis; brain; cattle; endothelial cells; erythrocytes; gene expression regulation; parasites; virulence;     Show all 9 Subjects
Abstract:
... The factors involved in gain or loss of virulence in Babesia bovis are unknown. Spherical body protein 2 truncated copy 11 (sbp2t11) transcripts in B. bovis were recently reported to be a marker of attenuation for B. bovis strains. Increased cytoadhesion of B. bovis-infected red blood cells (iRBC) to vascular endothelial cells is associated with severe disease outcomes and an indicator of parasite ...
DOI:
10.1016/j.ijpara.2018.05.015

15. Effect of target spot on soybean yield and factors affecting this relationship

Author:
Edwards Molina, J. P.; Paul, P. A.; Amorim, L.; da Silva, L. H. C. P.; Siqueri, F. V.; Borges, E. P.; Campos, H. D.; Venancio, W. S.; Meyer, M. C.; Martins, M. C.; Balardin, R. S.; Carlin, V. J.; Grigolli, J. F. J.; Belufi, L. M. de R.; Nunes Junior, J.; Godoy, C. V.
Source:
Plant pathology 2019 v.68 no.1 pp. 107-115
ISSN:
0032-0862
Subject:
disease severity,   etc   ; crop yield; cultivars; fungicides; growing season; models; regression analysis; soybeans; Brazil;     Show all 9 Subjects
Abstract:
... The lack of robust estimates of soybean yield losses due to target spot led to this study. The objective was to determine whether soybean yield at stage R8 (W, expressed as kg ha⁻¹) was related to target spot severity at soybean stage R5–R6 (S, expressed as %) and to identify variables that could affect this relationship. Plot‐level estimates of mean disease severity and yield from 41 selected Uni ...
DOI:
10.1111/ppa.12944

16. Evaluation of resistance to cassava mosaic disease in selected African cassava cultivars using combined molecular and greenhouse grafting tools

Author:
Houngue, Jerome Anani; Zandjanakou-Tachin, Martine; Ngalle, Hermine Bille; Pita, Justin S.; Cacaï, Gilles Habib Todjro; Ngatat, Sergine E.; Bell, Joseph Martin; Ahanhanzo, Corneille
Source:
Physiological and molecular plant pathology 2019 v.105 pp. 47-53
ISSN:
0885-5765
Subject:
disease severity,   etc   ; Manihot esculenta; breeding programs; cassava; cultivars; genetic markers; greenhouses; polymerase chain reaction; Africa;     Show all 9 Subjects
Abstract:
... Cassava mosaic disease (CMD) threatens cassava (Manihot esculenta) production in Africa. A total of 24 selected cultivars were screened against CMD using combined molecular and greenhouse grafting tools. Disease severity was recorded for 10 weeks after inoculation and the molecular markers associated with CMD2 were detected by PCR. CMD severity significantly differed (P < 0.0001) among cultivars. ...
DOI:
10.1016/j.pmpp.2018.07.003

17. Variable 3’polyadenylation of Wheat yellow mosaic virus and its novel effects on translation and replication

Author:
Geng, Guowei; Yu, Chengming; Li, Xiangdong; Yuan, Xuefeng
Source:
Virology journal 2019 v.16 no.1 pp. 23
ISSN:
1743-422X
Subject:
disease severity,   etc   ; 3' untranslated regions; 5' untranslated regions; Wheat yellow mosaic virus; genes; genomics; luciferase; translation (genetics); wheat; China;     Show all 10 Subjects
Abstract:
... BACKGROUND: Polyadenylation influences many aspects of mRNA as well as viral RNA. variable polyadenylation at the 3' end have been reported in RNA viruses. It is interesting to identify the characteristic and potential role of 3' polyadenylation of Wheat yellow mosaic virus (WYMV), which has been reported to contain two genomic RNAs with 3' poly(A) tails and caused severe disease on wheat in East ...
DOI:
10.1186/s12985-019-1130-z

18. Nanomaterial designing strategies related to cell lysosome and their biomedical applications: A review

Author:
Rathore, Bhowmira; Sunwoo, Kyoung; Jangili, Paramesh; Kim, Jiseon; Kim, Ji Hyeon; Huang, Meina; Xiong, Jia; Sharma, Amit; Yang, Zhigang; Qu, Junle; Kim, Jong Seung
Source:
Biomaterials 2019 v.211 pp. 25-47
ISSN:
0142-9612
Subject:
disease severity,   etc   ; autophagy; biomedical research; cell membranes; enzymes; eukaryotic cells; image analysis; ligands; lysosomes; mitochondria; nanomaterials; therapeutics; uptake mechanisms;     Show all 13 Subjects
Abstract:
... Lysosomes, an important organelle of eukaryotic cells, are covered with the cell membrane and contain an array of degradative enzymes. The disrupt in lysosomal functions may lead to the development of severe diseases. In nanotechnology, nanomaterials working mechanism and its biomedical output are highly dependent on the lysosomes as it plays a crucial role in intracellular transport. Several nano ...
DOI:
10.1016/j.biomaterials.2019.05.002

19. Identification of Resistant Sources Against Anthracnose Disease Caused by Colletotrichum truncatum and Colletotrichum gloeosporioides in Capsicum annuum L.

Author:
Mishra, Rukmini; Rout, Ellojita; Joshi, Raj Kumar
Source:
Proceedings of the National Academy of Sciences, India, Section B: biological sciences 2019 v.89 no.2 pp. 517-524
ISSN:
0369-8211
Subject:
disease severity,   etc   ; Capsicum annuum; Colletotrichum truncatum; Glomerella cingulata; anthracnose; breeding; breeding programs; disease resistance; fruits; genotype; pathogens; screening; India;     Show all 13 Subjects
Abstract:
... Anthracnose disease of chili (Capsicum annuum Linnaeus.) caused by Colletotrichum spp. has been a serious constraint to chili production worldwide. Two species- Colletotrichum truncatum and Colletotrichum gloeosporioides are known to cause anthracnose of chili in India of which the former is the most predominant one. Host resistance breeding is the most effective method to control anthracnose in c ...
DOI:
10.1007/s40011-018-0965-1

20. A comparative in silico linear B-cell epitope prediction and characterization for South American and African Trypanosoma vivax strains

Author:
Guedes, Rafael Lucas Muniz; Rodrigues, Carla Monadeli Filgueira; Coatnoan, Nicolas; Cosson, Alain; Cadioli, Fabiano Antonio; Garcia, Herakles Antonio; Gerber, Alexandra Lehmkuhl; Machado, Rosangela Zacarias; Minoprio, Paola Marcella Camargo; Teixeira, Marta Maria Geraldes; de Vasconcelos, Ana Tereza Ribeiro
Source:
Genomics 2019 v.111 no.3 pp. 407-417
ISSN:
0888-7543
Subject:
disease severity,   etc   ; B-lymphocytes; Trypanosoma vivax; diagnostic techniques; epitopes; genome; parasites; prediction; recombinant antigens; transcriptome; virulence; Brazil; Nigeria; Venezuela;     Show all 14 Subjects
Abstract:
... Trypanosoma vivax is a parasite widespread across Africa and South America. Immunological methods using recombinant antigens have been developed aiming at specific and sensitive detection of infections caused by T. vivax. Here, we sequenced for the first time the transcriptome of a virulent T. vivax strain (Lins), isolated from an outbreak of severe disease in South America (Brazil) and performed ...
DOI:
10.1016/j.ygeno.2018.02.017