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1. Dampening antiviral immunity can protect the host

Author:
Camilla Panetti; Kung‐Chi Kao; Nicole Joller
Source:
FEBS journal 2022 v.289 no.3 pp. 634-646
ISSN:
1742-464X
Subject:
disease severity,   etc   ; immune response; pathogens; viruses;     Show all 4 Subjects
Abstract:
... Viral infections are very common, and in most cases, the virus is well controlled and eliminated by the immune system. Nevertheless, in some cases, damage of the host tissue inflicted by the virus itself or by the elicited immune response may result in severe disease courses. Thus, regulatory mechanisms are necessary to control virus‐induced and immune pathology. This ensures immune responses are ...
DOI:
10.1111/febs.15756

2. Management of Septoria Tritici Blotch Using Cultivar Mixtures

Author:
Rose Kristoffersen; Lars Bonde Eriksen; Ghita Cordsen Nielsen; Johannes Ravn Jørgensen; Lise Nistrup Jørgensen
Source:
Plant disease 2022 v.106 no.5 pp. 1341-1349
ISSN:
0191-2917
Subject:
disease severity,   etc   ; Mycosphaerella graminicola; cultivars; fungicides; wheat; yields; Denmark;     Show all 7 Subjects
Abstract:
... Septoria tritici blotch (STB) is among the most devastating diseases in European wheat production. In recent years, there has been increased interest in using cultivar mixtures as part of an integrated control strategy against diseases. This study investigated different cultivar mixtures for their ability to control STB across three years and at seven trial sites in Denmark with a range of fungici ...
DOI:
10.1094/PDIS-01-21-0069-RE

3. Plant disease severity estimated visually: a century of research, best practices, and opportunities for improving methods and practices to maximize accuracy

Author:
Clive H. Bock; Kuo-Szu Chiang; Emerson M. Del Ponte
Source:
Tropical plant pathology 2022 v.47 no.1 pp. 25-42
ISSN:
1983-2052
Subject:
disease severity,   etc   ; phenotype; plant pathology; psychophysics; tropical plants; wheat;     Show all 6 Subjects
Abstract:
... Plant disease quantification, mainly the intensity of disease symptoms on individual units (severity), is the basis for a plethora of research and applied purposes in plant pathology and related disciplines. These include evaluating treatment effect, monitoring epidemics, understanding yield loss, and phenotyping for host resistance. Although sensor technology has been available to measure disease ...
DOI:
10.1007/s40858-021-00439-z

4. BMI Metrics Are Poor Predictors of Pediatric Nonalcoholic Fatty Liver Disease Severity

Author:
Corie M. Klepper; Tarush Khurana; Qin Sun; Lin Fei; Nancy A. Crimmins; Robert Siegel; Marialena Mouzaki
Source:
Childhood obesity 2022 pp. -
ISSN:
2153-2176
Subject:
disease severity,   etc   ; childhood obesity; fatty liver; histology; regression analysis; retrospective studies;     Show all 6 Subjects
Abstract:
... Background: Alternative BMI metrics are superior to BMI z score (BMIz) in tracking obesity but have not been evaluated in patients with nonalcoholic fatty liver disease (NAFLD). Our objective was to evaluate whether BMI-adjusted z score (BMIaz) or BMI expressed as a percentage of the 95th percentile (%BMIp95) are better predictors of degree of alanine aminotransferase (ALT) elevation, a surrogate ...
DOI:
10.1089/chi.2021.0316

5. Correlations between Electro-Diagnostic Findings, the Severity of Initial Infection, and the Rehabilitation Outcomes among COVID-19 Patients

Author:
Sheer Shabat; Zeev Meiner; Jeanna Tsenter; Isabella Schwartz; Sigal Portnoy
Source:
Biology 2022 v.11 no.2 pp. -
ISSN:
2079-7737
Subject:
disease severity,   etc   ; COVID-19 infection; electromyography; nerve tissue; prognosis; tibia; variance;     Show all 7 Subjects
Abstract:
... Patients with Coronavirus-2019 (COVID-19) manifest many neuromuscular complications. We evaluated the correlations between electromyography and nerve conduction measurements among COVID-19 patients and the severity of the initial infection, as well as the rehabilitation outcomes, and searched for the factors which best predict the rehabilitation outcomes. A total of 19 COVID-19 patients (16 men; m ...
DOI:
10.3390/biology11020277

6. Incidence, Disease Severity, and Follow-Up of Influenza A/A, A/B, and B/B Virus Dual Infections in Children: A Hospital-Based Digital Surveillance Program

Author:
Patrick E. Obermeier; Lea D. Seeber; Maren Alchikh; Brunhilde Schweiger; Barbara A. Rath
Source:
Viruses 2022 v.14 no.3 pp. -
ISSN:
1999-4915
Subject:
disease severity,   etc   ; Orthomyxoviridae; influenza; influenza vaccination; mixed infection; monitoring; viruses; Germany;     Show all 8 Subjects
Abstract:
... Influenza virus (IV) coinfection, i.e., simultaneous infection with IV and other viruses, is a common occurrence in humans. However, little is known about the incidence and clinical impact of coinfection with two different IV subtypes or lineages (“dual infections”). We report the incidence, standardized disease severity, and follow-up of IV dual infections from a hospital-based digital surveillan ...
DOI:
10.3390/v14030603

7. Neutrophil to lymphocyte ratio as a prognostic biomarker in puppies with acute diarrhea

Author:
Ceren Dinler Ay
Source:
Journal of veterinary emergency and critical care 2022 v.32 no.1 pp. 83-89
ISSN:
1479-3261
Subject:
disease severity,   etc   ; biomarkers; clinical examination; diarrhea; hospitals; inflammation; neutrophils; retrospective studies;     Show all 8 Subjects
Abstract:
... OBJECTIVES: To document the neutrophil to lymphocyte ratio (NLR) values in systemic inflammatory response syndrome positive (SIRS+) and negative (SIRS–) puppies presenting with acute diarrhea (AD). To determine whether the calculated canine acute diarrhea severity index (CADSI) score was associated with NLR. Also, to investigate the prognostic value of NLR in puppies with acute diarrhea. DESIGN: R ...
DOI:
10.1111/vec.13159

8. Directly interface microreaction tube and test strip for the detection of Salmonella in food with combined isothermal amplification and lateral flow assay

Author:
Yi Zhang; Aysha Farwin; Jackie Y. Ying
Source:
Food microbiology 2022 v.107 pp. 104062
ISSN:
0740-0020
Subject:
disease severity,   etc   ; DNA; Salmonella; death; detection limit; foodborne bacterial pathogens; genes; liquids;     Show all 8 Subjects
Abstract:
... Salmonella is a common foodborne bacterial pathogen that leads to severe illness or even death. The recommended method for Salmonella detection relies on the culture and has a long turnaround time of up to ∼1 week. In this study, we have developed a molecular assay that detects Salmonella in food by targeting the invA gene using loop-mediated isothermal amplification (LAMP) and lateral flow assay ...
DOI:
10.1016/j.fm.2022.104062

9. Development and validation of a diagrammatic scale for white mold incidence in tobacco leaf discs

Author:
Fernanda Souza Lopes; Edson Ampélio Pozza; Antonio Carlos Mota Porto; Caroline Marcela da Silva; Luciana Aparecida Miguel; Welison Andrade Pereira
Source:
Australasian plant pathology 2022 v.51 no.1 pp. 31-38
ISSN:
0815-3191
Subject:
disease severity,   etc   ; Brassicaceae; Sclerotinia sclerotiorum; leaves; lettuce; pathogens; plant pathology; potatoes; tobacco; tomatoes;     Show all 10 Subjects
Abstract:
... Sclerotinia sclerotiorum is a geographically cosmopolitan species with a wide ecological distribution, although it is most common in temperate regions. More than 400 plant species are susceptible to this pathogen, including most vegetables (e.g., potato, tomato, lettuce, and crucifers), tobacco, and major crops. This study aimed to develop and validate a diagrammatic scale to aid in the visual ass ...
DOI:
10.1007/s13313-021-00828-7

10. Proteomic quantification of perturbation to pharmacokinetic target proteins in liver disease

Author:
Areti-Maria Vasilogianni; Eman El-Khateeb; Zubida M. Al-Majdoub; Sarah Alrubia; Amin Rostami-Hodjegan; Jill Barber; Brahim Achour
Source:
Journal of proteomics 2022 v.263 pp. 104601
ISSN:
1874-3919
Subject:
disease severity,   etc   ; disease progression; drugs; liver; liver diseases; peptides; pharmacokinetics; protein content; proteomics;     Show all 9 Subjects
Abstract:
... Model-based assessment of drug pharmacokinetics in liver disease requires quantification of abundance and disease-related changes in hepatic enzymes and transporters. This study aimed to assess performance of three label-free methods [high N (HiN), intensity-based absolute quantification (iBAQ) and total protein approach (TPA)] against QconCAT-based targeted data in healthy and diseased (cancer an ...
DOI:
10.1016/j.jprot.2022.104601

11. Rapid and accurate detection of SARS-CoV-2 mutations using a Cas12a-based sensing platform

Author:
Changsheng He; Cailing Lin; Guosheng Mo; Binbin Xi; An′an Li; Dongchao Huang; Yanbin Wan; Feng Chen; Yufeng Liang; Qingxia Zuo; Wanqing Xu; Dongyan Feng; Guanting Zhang; Liya Han; Changwen Ke; Hongli Du; Lizhen Huang
Source:
Biosensors & bioelectronics 2022 v.198 pp. 113857
ISSN:
0956-5663
Subject:
disease severity,   etc   ; Severe acute respiratory syndrome coronavirus 2; biosensors; fluorescence; mutants; rapid methods;     Show all 6 Subjects
Abstract:
... The increasing prevalence of SARS-CoV-2 variants with spike mutations has raised concerns owing to higher transmission rates, disease severity, and escape from neutralizing antibodies. Rapid and accurate detection of SARS-CoV-2 variants provides crucial information concerning the outbreaks of SARS-CoV-2 variants and possible lines of transmission. This information is vital for infection prevention ...
DOI:
10.1016/j.bios.2021.113857

12. Identification and Fine-Mapping of a Novel QTL, qMrdd2, That Confers Resistance to Maize Rough Dwarf Disease

Author:
Zhennan Xu; Feifei Wang; Zhiqiang Zhou; Qingchang Meng; Yanping Chen; Xiaohua Han; Shuanggui Tie; Changlin Liu; Zhuanfang Hao; Mingshun Li; Degui Zhang; Jienan Han; Zhenhua Wang; Xinhai Li; Jianfeng Weng
Source:
Plant disease 2022 v.106 no.1 pp. 65-72
ISSN:
0191-2917
Subject:
disease severity,   etc   ; chromosomes; corn; disease resistance; haplotypes; phenotypic variation; prediction; progeny; substitution lines; viruses;     Show all 10 Subjects
Abstract:
... Maize rough dwarf disease (MRDD) is caused by a virus and seriously affects maize quality and yield worldwide. MRDD can be most effectively controlled with disease-resistant hybrids of corn. Here, MRDD-resistant (Qi319) and -susceptible (Ye478) parental inbred maize lines and their 314 recombinant inbred lines (RILs) that were derived from a cross between them were evaluated across three environme ...
DOI:
10.1094/PDIS-03-20-0495-RE

13. Innate Immunity to Orthohantaviruses: Could Divergent Immune Interactions Explain Host-specific Disease Outcomes?

Author:
Alison M. Kell
Source:
Journal of molecular biology 2022 v.434 no.6 pp. 167230
ISSN:
0022-2836
Subject:
disease severity,   etc   ; Orthohantavirus; antagonism; fever; host specificity; humans; innate immunity; insectivores; molecular biology; rodents;     Show all 10 Subjects
Abstract:
... The genus Orthohantavirus (family Hantaviridae, order Bunyavirales) consists of numerous genetic and pathologically distinct viral species found within rodent and mammalian insectivore populations world-wide. Although reservoir hosts experience persistent asymptomatic infection, numerous rodent-borne orthohantaviruses cause severe disease when transmitted to humans, with case-fatality rates up to ...
DOI:
10.1016/j.jmb.2021.167230

14. Maladaptive innate immune training of myelopoiesis links inflammatory comorbidities

Author:
Xiaofei Li; Hui Wang; Xiang Yu; Gundappa Saha; Lydia Kalafati; Charalampos Ioannidis; Ioannis Mitroulis; Mihai G. Netea; Triantafyllos Chavakis; George Hajishengallis
Source:
Cell 2022 v.185 no.10 pp. 1709-1727.e18
ISSN:
0092-8674
Subject:
disease severity,   etc   ; arthritis; bone marrow; epigenetics; inflammation; innate immunity; interleukin-1; periodontitis; phenotype; progeny;     Show all 10 Subjects
Abstract:
... Bone marrow (BM)-mediated trained innate immunity (TII) is a state of heightened immune responsiveness of hematopoietic stem and progenitor cells (HSPC) and their myeloid progeny. We show here that maladaptive BM-mediated TII underlies inflammatory comorbidities, as exemplified by the periodontitis-arthritis axis. Experimental-periodontitis-related systemic inflammation in mice induced epigenetic ...
DOI:
10.1016/j.cell.2022.03.043

15. Association between serum 25-hydroxy vitamin D levels and severity of asthma

Author:
Samrad Mehrabi; Elham Toghraee
Source:
Clinical nutrition ESPEN 2022 pp. -
ISSN:
2405-4577
Subject:
disease severity,   etc   ; adrenal cortex hormones; asthma; blood serum; calcium; clinical nutrition; lung function; phosphorus; risk;     Show all 9 Subjects
Abstract:
... Asthma prevalence has increased significantly since the 1960s. Increased airway hyperresponsiveness, decreased pulmonary function, poor asthma management, and steroid resistance have all been linked to vitamin D insufficiency. In addition, treatment with oral corticosteroids increases the risk of vitamin D deficiency. We studied patients with asthma regarding their vitamin D status and its associa ...
DOI:
10.1016/j.clnesp.2022.04.025

16. Known Cellular and Receptor Interactions of Animal and Human Coronaviruses: A Review

Author:
Holly Everest; Phoebe Stevenson-Leggett; Dalan Bailey; Erica Bickerton; Sarah Keep
Source:
Viruses 2022 v.14 no.2 pp. -
ISSN:
1999-4915
Subject:
disease severity,   etc   ; Severe acute respiratory syndrome coronavirus 2; glycoproteins; humans; influenza; monitoring; pandemic; pathogenesis; viruses;     Show all 9 Subjects
Abstract:
... This article aims to review all currently known interactions between animal and human coronaviruses and their cellular receptors. Over the past 20 years, three novel coronaviruses have emerged that have caused severe disease in humans, including SARS-CoV-2 (severe acute respiratory syndrome virus 2); therefore, a deeper understanding of coronavirus host–cell interactions is essential. Receptor-bin ...
DOI:
10.3390/v14020351

17. Phosphonate applied as a pre-plant dip controls Ceratocystis paradoxa base rot of pineapple planting material

Author:
J. M. Anderson; J. R. Dean; K. G. Pegg
Source:
Australasian plant pathology 2022 v.51 no.2 pp. 245-249
ISSN:
0815-3191
Subject:
disease severity,   etc   ; Ceratocystis paradoxa; Phytophthora cinnamomi; Talaromyces funiculosus; heart rot; phosphonates; pineapples; plant pathology; potassium;     Show all 9 Subjects
Abstract:
... Base rot, caused by Ceratocystis paradoxa, can be a severe disease of pineapple planting material and can result in poor establishment of plants. Pre-plant dipping of pineapple crowns in potassium phosphonate is used to control Phytophthora cinnamomi root and heart rot and was tested for efficacy against base rot in this study. Dipping crowns in 0.5% potassium phosphonate for 2 min significantly r ...
DOI:
10.1007/s13313-022-00852-1

18. Increased Heparanase Levels in Urine during Acute Puumala Orthohantavirus Infection Are Associated with Disease Severity

Author:
Luz E. Cabrera; Constanze Schmotz; Moin A. Saleem; Sanna Lehtonen; Olli Vapalahti; Antti Vaheri; Satu Mäkelä; Jukka Mustonen; Tomas Strandin
Source:
Viruses 2022 v.14 no.3 pp. -
ISSN:
1999-4915
Subject:
disease severity,   etc   ; Hantaviridae infections; Puumala orthohantavirus; acute kidney injury; fever; glomerular filtration rate; permeability; proteinuria; urine;     Show all 9 Subjects
Abstract:
... Old–world orthohantaviruses cause hemorrhagic fever with renal syndrome (HFRS), characterized by acute kidney injury (AKI) with transient proteinuria. It seems plausible that proteinuria during acute HFRS is mediated by the disruption of the glomerular filtration barrier (GFB) due to vascular leakage, a hallmark of orthohantavirus–caused diseases. However, direct infection of endothelial cells by ...
DOI:
10.3390/v14030450

19. Intra-Specific Diversity of Leishmania major Isolates: A Key Determinant of Tunisian Zoonotic Cutaneous Leishmaniasis Clinical Polymorphism

Author:
Hanene Attia; Manel Rabia Sghaier; Aymen Bali; Fatma Zahra Guerfali; Sadok Chlif; Chiraz Atri; Nabil Belhaj-Hamida; Amor Zaatour; Adel Gharbi; Afif Ben-Salah; Koussay Dellagi; Dhafer Laouini
Source:
Microorganisms 2022 v.10 no.3 pp. -
ISSN:
2076-2607
Subject:
disease severity,   etc   ; Leishmania major; cutaneous leishmaniasis; genetic variation; growth models; intraspecific variation; lectins; parasites; promastigotes; virulence;     Show all 10 Subjects
Abstract:
... The clinical expression of zoonotic cutaneous leishmaniasis (ZCL) caused by Leishmania (L.) major parasites has a broad spectrum ranging from asymptomatic infection to self-limited cutaneous sores or severe disease. In concert with the host immune responses, the vector variability and the number of bites, genetic variation between L. major isolates might impact on the clinical output of the diseas ...
DOI:
10.3390/microorganisms10030505

20. The impact of lifetime coffee and tea loads on Multiple Sclerosis severity

Author:
Andrei Ivashynka; Maurizio A. Leone; Nadia Barizzone; Aliona Cucovici; Roberto Cantello; Domizia Vecchio; Miriam Zuccalà; Alessandro Pizzino; Massimiliano Copetti; Sandra D'Alfonso; Andrea Fontana
Source:
Clinical nutrition ESPEN 2022 v.47 pp. 199-205
ISSN:
2405-4577
Subject:
disease severity,   etc   ; alleles; clinical nutrition; confidence interval; cross-sectional studies; genotyping; lifestyle; risk; sclerosis; tea; Italy;     Show all 11 Subjects
Abstract:
... The association between lifestyle factors and Multiple Sclerosis (MS) disease severity and progression has been investigated to a lesser extent compared with susceptibility to the disease. We aimed to assess the impact of lifetime coffee and tea consumption on MS severity. Design: cross-sectional study. Two hundred and eight patients (139 females and 69 males) consecutively recruited at the Depart ...
DOI:
10.1016/j.clnesp.2021.12.014