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1. Dental invasive procedures in von Willebrand disease outpatients treated with high purity FVIII/VWF complex concentrate (Fanhdi®): experience of a single center

Author:
De Padua, Valeria; Romeo, Umberto; Santoro, Cristina; Bosco, Riccardo; Baldacci, Erminia; Ferretti, Antonietta; Malaspina, Francesco; Mazzucconi, Maria Gabriella; Gaglioti, Domenico
Source:
Heliyon 2020 v.6 no.2 pp. e03426
ISSN:
2405-8440
Subject:
disease severity,   etc   ; blood; patients;     Show all 3 Subjects
Abstract:
... To retrospectively assess the effectiveness and safety of customized hemostatic protocols using a plasma-derived, von Willebrand Factor (VWF)-containing Factor VIII concentrate (pdVWF/FVIII) in von Willebrand disease (VWD) patients undergoing dental invasive procedures.Protocol for each patient was drawn up by the Blood Unit based on the VWD type, disease severity, and type of treatment. pdFVIII/V ...
DOI:
10.1016/j.heliyon.2020.e03426

2. Molecular and metabolomic interventions for identifying potential bioactive molecules to mitigate diseases and their impacts on crop plants

Author:
Choudhary, Pooja; Aggarwal, Pooja Rani; Rana, Sumi; Nagarathnam, Radhakrishnan; Muthamilarasan, Mehanathan
Source:
Physiological and molecular plant pathology 2021 v.114 pp. 101624
ISSN:
0885-5765
Subject:
disease severity,   etc   ; disease progression; immunity; metabolomics; plant pathology; secondary metabolites;     Show all 6 Subjects
Abstract:
... The multifaceted defense response of plants involves bioactive natural compounds that recognize, intervene, and neutralize the incoming pathogens. Plant secondary metabolites play roles at different stages of infection and disease progression. Studies have shown the synthesis of specific metabolites to confer resistance or tolerance depending on disease severity and other related factors. However, ...
DOI:
10.1016/j.pmpp.2021.101624

3. Treatment complexity and caregiver burden are linked in owners of dogs with allergic/atopic dermatitis

Author:
Spitznagel, Mary Beth; Hillier, Andrew; Gober, Margaret; Carlson, Mark D.
Source:
Veterinary dermatology 2021 v.32 no.2 pp. 192
ISSN:
0959-4493
Subject:
disease severity,   etc   ; atopic dermatitis; caregivers; dogs; veterinary medicine;     Show all 5 Subjects
Abstract:
... BACKGROUND: Skin disease severity and treatment plan complexity are both related to owner experience of caregiver burden; however, to date they have not been examined simultaneously in owners of dogs with atopic or other chronic allergic dermatitis. HYPOTHESES/OBJECTIVES: We expected to replicate and extend previous work by showing that caregiver burden is linked to treatment complexity and diseas ...
DOI:
10.1111/vde.12938

4. Screening of Metrosideros polymorpha (‘ōhi‘a) varieties for resistance to Ceratocystis lukuohia

Author:
Luiz, Blaine; Stacy, Elizabeth A.; Keith, Lisa M.
Source:
Forest pathology 2021 v.51 no.1 pp. e12656
ISSN:
1437-4781
Subject:
disease severity,   etc   ; Ceratocystis; Metrosideros polymorpha; death; forests; mortality; trees;     Show all 7 Subjects
Abstract:
... Stands of the landscape‐dominant tree, Metrosideros polymorpha (‘ōhi‘a) on the Island of Hawai‘i, HI., USA, are dying from a phenomenon known as rapid ‘ōhi‘a death (ROD). Approximately 180,000 acres of forest have already been impacted by the disease, the majority of which is attributed to C. lukuohia, the more aggressive of the two Ceratocystis species responsible for ROD. Three isolates of C. lu ...
DOI:
10.1111/efp.12656

5. T-cell dysregulation in COVID-19

Author:
Kalfaoglu, Bahire; Almeida-Santos, José; Tye, Chanidapa Adele; Satou, Yorifumi; Ono, Masahiro
Source:
Biochemical and biophysical research communications 2021 v.538 pp. 204-210
ISSN:
0006-291X
Subject:
disease severity,   etc   ; COVID-19 infection; cytotoxicity; immunity; immunopathology; research;     Show all 6 Subjects
Abstract:
... T-cells play key roles in immunity to COVID-19 as well as the development of severe disease. T-cell immunity to COVID-19 is mediated through differentiated CD4⁺ T-cells and cytotoxic CD8⁺ T-cells, although their differentiation is often atypical and ambiguous in COVID-19 and single cell dynamics of key genes need to be characterized. Notably, T-cells are dysregulated in severe COVID-19 patients, a ...
DOI:
10.1016/j.bbrc.2020.10.079

6. Long‐term recurrent, yet nonprogressive, pedal viral papillomas in a dog

Author:
Munday, John S.; Piripi, Susan A.; Julian, Alan; Martin, Scott J.
Source:
Veterinary dermatology 2020 v.31 no.6 pp. 489
ISSN:
0959-4493
Subject:
disease severity,   etc   ; dogs; veterinary medicine;     Show all 3 Subjects
Abstract:
... Viral papillomas that developed on the toe of a dog, were removed and recurred four times in two years. Despite the papillomas being ‘persistent’, they remained small and confined to the toe, and did not spread or progress to severe disease. Not all persistent papillomas will progress, even when these are treated using more conservative therapies. ...
DOI:
10.1111/vde.12888

7. Edema in critically ill patients leads to overestimation of skeletal muscle mass measurements using computed tomography scans

Author:
Baggerman, Michelle R.; van Dijk, David P.J.; Winkens, Bjorn; Schnabel, Ronny M.; van Gassel, Rob J.J.; Bol, Martine E.; Bakers, Frans C.; Olde Damink, Steven W.M.; van de Poll, Marcel C.G.
Source:
Nutrition 2021 v.89 pp. 111238
ISSN:
0899-9007
Subject:
disease severity,   etc   ; computed tomography; edema; lipids; muscles; nutrition; nutritional intervention; skeletal muscle; vertebrae;     Show all 9 Subjects
Abstract:
... Changes in muscle mass and quality are important targets for nutritional intervention in critical illness. Effects of such interventions may be assessed using sequential computed tomography (CT) scans. However, fluid and lipid infiltration potentially affects muscle area measurements. The aim of this study was to evaluate changes in muscle mass and quality in critical illness with special emphasis ...
DOI:
10.1016/j.nut.2021.111238

8. Inhibition of regulator of G protein signaling 10, aggravates rheumatoid arthritis progression by promoting NF-κB signaling pathway

Author:
Ren, Jie; Wei, Wei; Tan, Liangyu; Yang, Qin; Lu, Qiuyu; Ding, Handong; Yue, Yuan; Tian, Ye; Hao, Liang; Wang, Min; Li, Jinle
Source:
Molecular immunology 2021 v.134 pp. 236-246
ISSN:
0161-5890
Subject:
disease severity,   etc   ; Dependoparvovirus; etiology; immune response; inflammation; mice; rheumatoid arthritis; therapeutics;     Show all 8 Subjects
Abstract:
... Rheumatoid arthritis (RA) is the most common inflammatory arthropathy, with evidence pointing to an immune-mediated etiology that propagates chronic inflammation. Although targeted immune therapeutics and aggressive treatment strategies have substantially improved, a complete understanding of the associated pathological mechanisms of the disease remains elusive. This study aimed at investigating w ...
DOI:
10.1016/j.molimm.2021.03.024

9. Study of the relationship between untypable and typable isolates of Streptococcus suis recovered from clinically ill and healthy nursery pigs

Author:
Denich, Leann; Farzan, Abdolvahab; Friendship, Robert; Arndt, Emily; Ricker, Nicole; Gottschalk, Marcelo; Poljak, Zvonimir
Source:
Veterinary microbiology 2021 v.257 pp. 109064
ISSN:
0378-1135
Subject:
disease severity,   etc   ; Streptococcus suis; farms; microbiology; phylogeny; polysaccharides; respiratory system; serotypes; Ontario;     Show all 9 Subjects
Abstract:
... Streptococcus suis naturally colonizes the upper respiratory tract of pigs and can lead to severe disease conditions. Although there are several serotypes associated with disease, untypable isolates have also been observed. The objective of this study was to investigate the relatedness of untypable S. suis isolates detected in clinical cases and healthy pigs in Ontario, Canada, and their relation ...
DOI:
10.1016/j.vetmic.2021.109064

10. Comprehensive metabolic amino acid flux analysis in critically ill patients

Author:
Deutz, Nicolaas E.P.; Singer, Pierre; Wierzchowska-McNew, Raven A.; Viana, Marina V.; Ben-David, Itai A.; Pantet, Olivier; Thaden, John J.; Ten Have, Gabriella A.M.; Engelen, Mariëlle P.K.J.; Berger, Mette M.
Source:
Clinical nutrition 2021 v.40 no.5 pp. 2876-2897
ISSN:
0261-5614
Subject:
disease severity,   etc   ; blood; clinical nutrition; glutamic acid; glutamine; hydroxyproline; information; isotopes; metabolism; phenotype; phenylalanine; t-test;     Show all 12 Subjects
Abstract:
... Amino acid (AA) metabolism is severely disturbed in critically ill ICU patients. To be able to make a more scientifically based decision on the type of protein or AA nutrition to deliver in ICU patients, comprehensive AA phenotyping with measurements of plasma concentrations and whole body production (WBP) is needed. Therefore, we studied ICU patients and matched control subjects using a novel pul ...
DOI:
10.1016/j.clnu.2021.03.015

11. Clinical repercussions in pertussis infants post-Tdpa vaccination of pregnant woman: An immunization success?

Author:
de Miranda Lopes, Katiuscia Araujo; Baptista, Paulo Neves; de Medeiros Nascimento, Renata; Pimentel, Analíria; de Alencar Ximenes, Ricardo Arraes
Source:
Vaccine 2021 v.39 no.18 pp. 2555-2560
ISSN:
0264-410X
Subject:
disease severity,   etc   ; apnea; cough; death; gender; information systems; morbidity; mortality; pregnant women; vaccination; vaccines; Brazil;     Show all 12 Subjects
Abstract:
... In 2014, there was an epidemic of pertussis in Brazil that caused the death of 129 infants. To control the disease amongst infants under 6 months of age, and especially those under 2 months, the Brazilian Ministry of Health introduced Tdap immunization for all pregnant women.This study aimed to describe the morbidity and mortality variables of pertussis cases in 969 infants aged under 6 months, co ...
DOI:
10.1016/j.vaccine.2021.03.069

12. Probiotics and Covid-19

Author:
Bottari, Benedetta; Castellone, Vincenzo; Neviani, Erasmo
Source:
International journal of food sciences and nutrition 2021 v.72 no.3 pp. 293-299
ISSN:
1465-3478
Subject:
disease severity,   etc   ; COVID-19 infection; dysbiosis; intestinal microorganisms; nutrition; pandemic; probiotics; respiratory system; therapeutics;     Show all 9 Subjects
Abstract:
... Coronavirus disease 2019 (COVID-19) has become pandemic very rapidly at the beginning of 2020. In the rush to possible therapeutic options, probiotics administration has been proposed mainly based on indirect observation. Some evidence of COVID-19 effects on intestinal microbiota dysbiosis has been shown and probiotics have been considered for their efficacy in the management of respiratory tract ...
DOI:
10.1080/09637486.2020.1807475

13. Detection and identification of Kinetoplastids of zoonotic interest by HRM-qPCR analysis in Canis lupus familiaris from Argentinean Mesopotamia

Author:
Muñoz-Calderón, Arturo; Lucero, Raul Horacio; Brusés, Bettina L.; Formichelli, Laura; Koscinczuk, Patricia; Pedelhez, Mariana; Schijman, Alejandro G.
Source:
Veterinary Parasitology: Regional Studies and Reports 2021 v.24 pp. 100557
ISSN:
2405-9390
Subject:
disease severity,   etc   ; Canis lupus; Trypanosoma cruzi; Trypanosoma evansi; algorithms; genes; parasitemia; ribosomal DNA; veterinary parasitology; zoonoses;     Show all 10 Subjects
Abstract:
... This work aimed to conduct a first PCR-based approach for differential diagnosis of kinetoplastidean infections in dogs. Diagnosis of Kinetoplastid infections in domestic animals is difficult, since parasitemia is intermittent and signs are nonspecific; it is mainly based on parasitological smears or concentration techniques, which lack sensitivity and depend on operator` expertise. Dogs are relev ...
DOI:
10.1016/j.vprsr.2021.100557

14. Effect of oral vancomycin dose on outcomes in patients with Clostridioides difficile infection

Author:
O'Donnell, J. Nicholas; Novak, Gregory M.; Bratek, Benjamin R.; Singh, Gurkirat; Duru, Odirichukwu O.; Mitchell, Colby L.; Roddy, Kristina M.; Bidell, Monique R.
Source:
International journal of antimicrobial agents 2021 v.57 no.4 pp. 106311
ISSN:
0924-8579
Subject:
disease severity,   etc   ; Clostridium difficile; adults; demographic statistics; guidelines; hospitals; morbidity; mortality; probability; toxins; vancomycin;     Show all 11 Subjects
Abstract:
... Clostridioides difficile infection (CDI) is a significant cause of morbidity and mortality. Oral vancomycin is a cornerstone of CDI treatment, but dosing strategies in clinical practice may differ from guideline recommendations. This study aimed to determine differences in outcomes between patients treated with standard (125 mg QID) and high-dose (≥250 mg QID) oral vancomycin. This dual-centre stu ...
DOI:
10.1016/j.ijantimicag.2021.106311

15. Obesity, COVID-19 and innate immunometabolism

Author:
Gleeson, Laura E.; Roche, Helen M.; Sheedy, Frederick J.
Source:
The British journal of nutrition 2021 v.125 no.6 pp. 628-632
ISSN:
1475-2662
Subject:
disease severity,   etc   ; COVID-19 infection; energy metabolism; fat intake; innate immunity; mortality; obesity; pathogens;     Show all 8 Subjects
Abstract:
... As COVID-19 continues to spread worldwide, severe disease and mortality have been observed in obese patients. We discuss how obesity and obesity-associated factors such as ‘meta-flammation’, dietary fat intake and paradoxical suppression of the innate immune response within the pulmonary compartment may be crucial determinants in the host response to a novel viral pathogen. Modulation of immune ce ...
DOI:
10.1017/S0007114520003529

16. Influenza vaccination in immunocompromised populations: Strategies to improve immunogenicity

Author:
Caldera, Freddy; Mercer, Monica; Samson, Sandrine I.; Pitt, Jonathan M.; Hayney, Mary S.
Source:
Vaccine 2021 v.39 pp. A15
ISSN:
0264-410X
Subject:
disease severity,   etc   ; immunogenicity; immunosuppression; immunosuppressive agents; influenza; influenza vaccination; influenza vaccines; risk;     Show all 8 Subjects
Abstract:
... Immunocompromised individuals are at high risk of severe illness and complications from influenza infection. For this reason, immunization using inactivated influenza vaccines is recommended for transplant patients, individuals receiving immunosuppressant treatments, and other persons with immunodeficiency. However, these immunocompromised populations are more likely to have lower and non-protecti ...
DOI:
10.1016/j.vaccine.2020.11.037

17. First report of Apiognomonia errabunda on Quercus ilex in Algeria

Author:
Bensaci, Oussama Ali; Beghami, Riadh; Gouaref, Kamel
Source:
Folia forestalia Polonica 2021 v.63 no.1 pp. 10-20
ISSN:
2199-5907
Subject:
disease severity,   etc   ; Apiognomonia; Quercus ilex; anthracnose; fungi; leaves; morphs; national parks; spring; Algeria;     Show all 10 Subjects
Abstract:
... Anthracnose of holm oak (Quercus ilex L.) was studied in several sites located in Belezma National Park (Eastern Algeria). Disease severity varied according to the site, but symptoms were particularly frequent on leaves supported by south-facing twigs. Leaves inserted on the distal part of twigs were more affected by anthracnose regardless of twigs’ position on trees. The fungal isolates obtained ...
DOI:
10.2478/ffp-2021-0002

18. A first for Southern Africa: description of a new Heterobothrium (Monogenea: Diclidophoridae) parasitizing the evileye pufferfish Amblyrhynchotes honckenii (Tetraodontiformes: Tetraodontidae)

Author:
Acosta, Aline Angelina; Smit, Nico J.
Source:
Parasitology research 2021 v.120 no.3 pp. 819-830
ISSN:
0932-0113
Subject:
disease severity,   etc   ; ; Japan; Monogenea; Takifugu rubripes; genes; host specificity; parasitology; phylogeny; research; South Africa;     Show all 11 Subjects
Abstract:
... The monogenean genus Heterobothrium (Monogenea: Diclidophoridae) currently consists of 12 accepted species described globally from various pufferfishes (Tetraodontidae). This includes the economically important Heterobothrium okamotoi Ogawa 1991 that causes severe disease in the cultured tiger puffer Takifugu rubripes in Japan. During parasitological surveys targeting near shore marine fishes of S ...
DOI:
10.1007/s00436-020-06960-5

19. Foreword – The importance of a healthy microbiota in the era of COVID-19 : A year after the COVID-19 pandemic

Author:
Venema, Koen
Source:
Beneficial microbes 2021 v.12 no.1 pp. 1-3
ISSN:
1876-2891
Subject:
disease severity,   etc   ; COVID-19 infection; Orthomyxoviridae; cholesterol; intestinal microorganisms; vaccines; viruses; Asia; Europe;     Show all 9 Subjects
Abstract:
... At the start of 2020 we were thrilled to have reached 10 years of Beneficial Microbes! Little did we know that soon after Europe and the rest of the world (with Asia already earlier) would be in lock-down due to COVID-19. It has been a strange year. And now, at the start of 2021, the excitement of having a vaccine is tempered by the fact that everywhere mutants of the virus pop up. Although this w ...
DOI:
10.3920/BM2021.x001

20. Compromised SARS-CoV-2-specific placental antibody transfer

Author:
Atyeo, Caroline; Pullen, Krista M.; Bordt, Evan A.; Fischinger, Stephanie; Burke, John; Michell, Ashlin; Slein, Matthew D.; Loos, Carolin; Shook, Lydia L.; Boatin, Adeline A.; Yockey, Laura J.; Pepin, David; Meinsohn, Marie-Charlotte; Nguyen, Ngoc Minh Phuong; Chauvin, Maeva; Roberts, Drucilla; Goldfarb, Ilona T.; Matute, Juan D.; James, Kaitlyn E.; Yonker, Lael M.; Bebell, Lisa M.; Kaimal, Anjali J.; Gray, Kathryn J.; Lauffenburger, Douglas; Edlow, Andrea G.; Alter, Galit
Source:
Cell 2021 v.184 no.3 pp. 628-642.e10
ISSN:
0092-8674
Subject:
disease severity,   etc   ; Severe acute respiratory syndrome coronavirus 2; antibodies; glycosylation; immunity; placenta; serology; vaccine development;     Show all 8 Subjects
Abstract:
... SARS-CoV-2 infection causes more severe disease in pregnant women compared to age-matched non-pregnant women. Whether maternal infection causes changes in the transfer of immunity to infants remains unclear. Maternal infections have previously been associated with compromised placental antibody transfer, but the mechanism underlying this compromised transfer is not established. Here, we used syste ...
DOI:
10.1016/j.cell.2020.12.027