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dopamine, etc ; borax; catechol; nanosilver; polymerization; Show all 5 Subjects
Abstract:
... Polydopamine (PDA) nanoparticles and PDA-coated surfaces have wide applications due to PDA’s unique reactivity and efficient coating ability on nearly any surface. However, challenges in manipulating and controlling dopamine polymerization and thus the PDA nanoparticle formations and surface coatings still exist. Here, dopamine with a tetraborate (borax)-protected catechol group was utilized to tu ...
dopamine, etc ; calcium carbonate; citrates; crystallization; nanocarriers; Show all 5 Subjects
Abstract:
... Exquisite design of calcium carbonate (CaCO₃) is essential to meet the demands on the properties of functional materials for various applications, where additives play a crucial role in controlling over size, orientation, polymorph, and hierarchical structure. However, we are far from achieving the elaborate control over their structures and morphologies by use of the individual additive. Herein, ...
dopamine, etc ; adhesion; air; composite polymers; mussels; Show all 5 Subjects
Abstract:
... Despite the fact that synthetic adhesives have achieved great progress, achieving robust dry/wet adhesion under harsh operating environments is still challenging. Herein, inspired from the extraordinary adhesion mechanism of nature mussel protein adhesive, the balanced design concept of co-adhesion and interfacial adhesion is proposed to prepare one kind of novel copolymer adhesive of [poly(dopami ...
dopamine, etc ; ambient temperature; durability; electrical resistance; Show all 4 Subjects
Abstract:
... The lab-synthesized ceria (CeO₂) nanoparticles were surface-modified to provide proton conductivity. The dopamine sulfonated ceria (CeO₂-DS) nanoparticles were embedded into the thin surface layers of Nafion 212 membranes, resulting in the sandwiched structure. The structure, morphology and properties of the synthesized nanoparticles and membranes were analyzed using a variety of methods including ...
... Oxidative stress and neuroinflammation are common bases for disease onset and progression in many neurodegenerative diseases. In Parkinson disease, which is characterized by the degeneration of dopaminergic neurons resulting in dopamine depletion, the pathogenesis differs between hereditary and solitary disease forms and is often unclear. In addition to the pathogenicity of alpha-synuclein as a pa ...
Nicholas J. Fiore; Yosif M. Ganat; Kapil Devkota; Rebecca Batorsky; Ming Lei; Kyongbum Lee; Lenore J. Cowen; Gist Croft; Scott A. Noggle; Thomas J. F. Nieland; David L. Kaplan
dopamine, etc ; gene expression; humans; metabolites; neurons; silk; transcriptomics; Show all 7 Subjects
Abstract:
... Three-dimensional (3D) in vitro culture systems using human induced pluripotent stem cells (hiPSCs) are useful tools to model neurodegenerative disease biology in physiologically relevant microenvironments. Though many successful biomaterials-based 3D model systems have been established for other neurogenerative diseases, such as Alzheimer’s disease, relatively few exist for Parkinson’s disease (P ...
dopamine, etc ; DNA; DNA methylation; mice; neurons; prefrontal cortex; Show all 6 Subjects
Abstract:
... DNA methylation plays essential roles in various cellular processes. Next-generation sequencing has enabled us to study the functional implication of DNA methylation across the whole genome. However, this approach usually requires a substantial amount of genomic DNA, which limits its application to defined cell types within a discrete brain region. Here, we applied two separate protocols, Accel-NG ...
dopamine, etc ; Lewis bases; alkylation; amides; catechol; nitrogen; oxidation; quinones; Show all 8 Subjects
Abstract:
... Dopamine (DA) surface chemistry has received significant attention because of its applicability in a wide range of research fields and the ability to graft functional molecules onto numerous solid surfaces. Various DA derivatives have been newly synthesized to identify key factors affecting the coating efficiency and to advance the coating system development. The oxidation of catechol into quinone ...
dopamine, etc ; blood serum; detection limit; fluorescence; gold; nanoflowers; synergism; Show all 7 Subjects
Abstract:
... We developed a trace level detection method for dopamine (DA) based on the metal-enhanced fluorescence (MEF) effect of gold nanoflowers (AuNFs). AuNFs prepared were excellent enhancement fluorescence substrates due to their unique morphology with rich edges and sharp quoins. DA was the target analyte and also as a bridge reagent that could regulate the distance between AuNFs and Tb³⁺. The characte ...
dopamine, etc ; adhesion; catechol; cohesion; electronics; evaporation; hydrogen; ionic liquids; polymers; Show all 9 Subjects
Abstract:
... Liquid-free ionic conductors (LFICs) have promising applications in flexible electronics because most ionic conductors currently suffer from ionic liquid leakage or water evaporation issues. However, it has been a formidable challenge for LFICs to achieve long-term repeated self-adhesion on different substrates, especially on soft biological tissues. Based on the double-network design concept, we ...
dopamine, etc ; anodes; carbon nanotubes; electrochemistry; energy; hot water treatment; lithium; Show all 7 Subjects
Abstract:
... It is necessary to design an anode material for lithium-ion batteries (LIBs) with good lithium storage capacity. In the present work, the CNTs@PDA/CoMoS₄ composite materials were prepared through self-polymerization of dopamine (PDA) and coating on carbon nanotubes and then deposition of CoMoS₄ by a hydrothermal method. Benefited from the formation of the coordination bond between the hydroxyl gro ...
dopamine, etc ; antagonists; brain; inflammasomes; interleukin-18; males; renin-angiotensin system; Show all 7 Subjects
Abstract:
... The tissue renin–angiotensin system (RAS) has been shown to be involved in prooxidative and proinflammatory changes observed in aging and aging-related diseases such as dopaminergic degeneration in Parkinson’s disease (PD). We studied the activation of the NLRP3 inflammasome in the substantia nigra with aging and early stages of dopaminergic degeneration in PD models and, particularly, if the brai ...
dopamine, etc ; calcium channels; emotions; extinction; genes; habituation; physiology; rats; ultrasonics; Show all 9 Subjects
Abstract:
... We have previously shown that rats emit high-frequency 50 kHz ultrasonic vocalizations (USV) during sign- and goal-tracking in a common Pavlovian conditioned approach task. Such 50 kHz calls are probably related to positive affect and are associated with meso-limbic dopamine function. In humans, the CACNA1C gene, encoding for the α₁C subunit of the L-type voltage-gated calcium channel CaV1.2, is i ...
dopamine, etc ; Tityus bahiensis; hippocampus; metabolism; metabolites; neurotransmitters; scorpion venoms; toxins; Show all 8 Subjects
Abstract:
... Tb II-I isolated from Tityus bahiensis venom causes epileptic-discharges when injected into the hippocampus of rats. The involvement of neurotransmitters in this activity was investigated. Our results demonstrated that Tb II-I increases the concentrations of dopamine metabolite but does not alter other neurotransmitters. Thus, dopaminergic system seems to be partially responsible for the convulsiv ...
dopamine, etc ; biosensors; electrochemiluminescence; electrochemistry; hypoxia; microarray technology; oligonucleotides; oxidation; polymers; secretion; Show all 10 Subjects
Abstract:
... The quantitative detection of single cell secretions is always limited by their accurate collection and the heterogeneity of different cells. In this work, a confined electrochemiluminescence (ECL) imaging microarray (CEIM) chip was designed to capture single or a few cells in each cylindrical microwell for high-throughput quantitation of cell-secreted dopamine (DA). The ITO surface at the bottom ...
dopamine, etc ; G-protein coupled receptors; adenosine; biotechnology; ligands; molecular dynamics; pharmacology; Show all 7 Subjects
Abstract:
... Development of effective bivalent ligands has become the focus of intensive research toward modulation of G protein-coupled receptor (GPCR) oligomers, particularly in the field of GPCR pharmacology. Experimental studies have shown that they increased binding affinity and signaling potency compared to their monovalent counterparts, yet underlying molecular mechanism remains elusive. To address this ...
dopamine, etc ; antibodies; fever; luminescence; molecular imprinting; nanomedicine; neoplasms; photothermotherapy; sialic acid; Show all 9 Subjects
Abstract:
... Actively tumor-targeted photothermal therapy (PTT) has been regarded as an attractive strategy for tumor treatment. Unfortunately, invasive damage caused by hyperthermia, irrepressible heating transfer and self-heating from in-organism water is always a real ‘hot potato’ in existing PTT modes. Herein, molecularly imprinted upconversion nanoparticles (UCPs@MIPs) were innovatively reported as an art ...
dopamine, etc ; absorbance; composite films; hydrogen; photocatalysis; tensile strength; ultraviolet radiation; zinc; Show all 8 Subjects
Abstract:
... Zinc oxide@polydopamine (ZnO@PDA) core-shell nanoparticles (NPs) were prepared by depositing PDA on the surface of ZnO NPs via the self-polymerization of dopamine (DA) in alkaline solution. It was found that ZnO@PDA exhibits lower photocatalytic activity and higher UV absorbance than pure ZnO. Moreover, ZnO@PDA NPs could be homogenously dispersed in poly(vinyl alcohol) (PVA) matrix and form strong ...
dopamine receptors, etc ; Corydalis; antagonism; circular dichroism spectroscopy; moieties; plant biochemistry; spectral analysis; Show all 7 Subjects
Abstract:
... Eleven undescribed isoquinoline alkaloids corybungines A−K including a protoberberine-type alkaloid, an isoquinoline alkaloid with a unique 6-norprotoberberine skeleton, one 13,14-seco-protoberberine-type alkaloid, two 1a,14-seco-protoberberine-type alkaloids with a 4-(hydroxymethyl)phenoxy moiety and six aporphine alkaloids, together with seven known alkaloids, have been isolated from the whole h ...
dopamine, etc ; catalysts; electrochemistry; electrolytes; electron transfer; energy; manganese; microbial electrolysis cells; pH; Show all 9 Subjects
Abstract:
... Due to the complex of oxygen reduction reaction (ORR), designing catalysts with multicatalytic centers is considered as a promising way for boosting the ORR. Herein, a multicatalytic centers electrocatalyst Fe₃C/Mn₃O₄ encased by N-doped graphitic layers (FeMn PDA-900) is synthesized using iron manganese Prussian blue analogues and dopamine as the precursor. It exhibits a half-wave potential (E₁/₂) ...