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1. Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes

Author:
Xiao, Peng; Yan, Wei; Gou, Lu; Zhong, Ya-Ni; Kong, Liangliang; Wu, Chao; Wen, Xin; Yuan, Yuan; Cao, Sheng; Qu, Changxiu; Yang, Xin; Yang, Chuan-Cheng; Xia, Anjie; Hu, Zhenquan; Zhang, Qianqian; He, Yong-Hao; Zhang, Dao-Lai; Zhang, Chao; Hou, Gui-Hua; Liu, Huanxiang; Zhu, Lizhe; Fu, Ping; Yang, Shengyong; Rosenbaum, Daniel M.; Sun, Jin-Peng; Du, Yang; Zhang, Lei; Yu, Xiao; Shao, Zhenhua
Source:
Cell 2021 v.184 no.4 pp. 943-956.e18
ISSN:
0092-8674
Subject:
dopamine; dopamine receptors,   etc   ; agonists; cryo-electron microscopy; kidneys; ligands; therapeutics;     Show all 7 Subjects
Abstract:
... Dopamine receptors, including D1- and D2-like receptors, are important therapeutic targets in a variety of neurological syndromes, as well as cardiovascular and kidney diseases. Here, we present five cryoelectron microscopy (cryo-EM) structures of the dopamine D1 receptor (DRD1) coupled to Gs heterotrimer in complex with three catechol-based agonists, a non-catechol agonist, and a positive alloste ...
DOI:
10.1016/j.cell.2021.01.028

2. Fluid intake, what's dopamine got to do with it?

Author:
Mietlicki-Baase, Elizabeth G.; Santollo, Jessica; Daniels, Derek
Source:
Physiology & behavior 2021 v.236 pp. 113418
ISSN:
0031-9384
Subject:
dopamine,   etc   ; behavior; brain; sodium; thirst;     Show all 5 Subjects
Abstract:
... Maintaining fluid balance is critical for life. The central components that control fluid intake are only partly understood. This contribution to the collection of papers highlighting work by members of the Society for the Study of Ingestive Behavior focuses on the role that dopamine has on fluid intake and describes the roles that various bioregulators can have on thirst and sodium appetite by in ...
DOI:
10.1016/j.physbeh.2021.113418

3. Wave-like dopamine dynamics as a mechanism for spatiotemporal credit assignment

Author:
Hamid, Arif A.; Frank, Michael J.; Moore, Christopher I.
Source:
Cell 2021 v.184 no.10 pp. 2733-2749.e16
ISSN:
0092-8674
Subject:
dopamine,   etc   ; animal behavior; credit; prediction;     Show all 4 Subjects
Abstract:
... Significant evidence supports the view that dopamine shapes learning by encoding reward prediction errors. However, it is unknown whether striatal targets receive tailored dopamine dynamics based on regional functional specialization. Here, we report wave-like spatiotemporal activity patterns in dopamine axons and release across the dorsal striatum. These waves switch between activational motifs a ...
DOI:
10.1016/j.cell.2021.03.046

4. Enhanced microwave absorption performance of light weight N-doped carbon nanoparticles

Author:
Chen, Jianxin; Miao, Peng; Lin, E. Emily; Bai, Ting; Smoukov, Stoyan K.; Kong, Jie
Source:
RSC advances 2021 v.11 no.14 pp. 7954-7960
ISSN:
2046-2069
Subject:
dopamine,   etc   ; absorption; carbon nanoparticles; polymerization;     Show all 4 Subjects
Abstract:
... Microwave absorbents with specific morphology and structure have fundamental significance for tuning microwave absorption (MA). Herein, N-doped carbon sphere nanoparticles and hollow capsules were successfully fabricated via oxidative polymerization of dopamine in different mixed solutions, without any template preparation or etching process. Compared to solid particles, the microwave absorbents c ...
DOI:
10.1039/d0ra08455g

5. In situ formation of ultrathin polyampholyte layer on porous polyketone membrane via a one-step dopamine co-deposition strategy for oil/water separation with ultralow fouling

Author:
Zhang, Lei; Takagi, Ryosuke; Wang, Shengyao; Lin, Yuqing; Guan, Kecheng; Cheng, Liang; Matsuyama, Hideto
Source:
Journal of membrane science 2021 v.619 pp. 118789
ISSN:
0376-7388
Subject:
dopamine,   etc   ; adhesion; crosslinking; emulsions; hydrophilicity; oils; soybeans;     Show all 7 Subjects
Abstract:
... Fouling caused by oils or other pollutants is one of the most important obstacles for membrane application in oil/water separation. To improve the anti-oil-fouling property, a new polyampholyte layer of poly (2-methacryloyloxyethyl phosphorylcholine-co-2-aminoethyl methacrylate hydrochloride) (MPC-co-AEMA) was in situ formed on the porous polyketone membrane via an extremely simple one-step dopami ...
DOI:
10.1016/j.memsci.2020.118789

6. Modeling the activity of the dopamine signaling pathway by combination of analog electrical circuit and mathematical approaches

Author:
Shumilov, A.V.; Gotovtsev, P.M.
Source:
Heliyon 2021 v.7 no.1 pp. e05879
ISSN:
2405-8440
Subject:
dopamine,   etc   ; calcium; electronic circuits; mathematical models; phosphorylation;     Show all 5 Subjects
Abstract:
... This paper demonstrates the application of the system biology principles on the example of the dopamine signaling pathway in neurons. Presented model is based on two approaches – cytomorphic electronic circuits and mathematical modeling. Transcription and phosphorylation of DARPP-32 was modeled by analog circuit, based on well-known approaches presented in [1]. It was shown that application of cir ...
DOI:
10.1016/j.heliyon.2020.e05879

7. Role of D1- and D2-like dopamine receptors within the dentate gyrus in antinociception induced by chemical stimulation of the lateral hypothalamus in an animal model of acute pain

Author:
Khaleghzadeh-Ahangar, Hossein; Rashvand, Mina; Haghparast, Abbas
Source:
Physiology & behavior 2021 v.229 pp. 113214
ISSN:
0031-9384
Subject:
dopamine; dopamine receptors,   etc   ; adults; animal models; antagonists; behavior; cannulas; carbachol; hippocampus; hypothalamus; males; pain; pain tests;     Show all 13 Subjects
Abstract:
... The dentate gyrus (DG) as the main gateway of the hippocampal formation (HF) plays a crucial role in pain modulation. For this purpose, the HF receives dopaminergic inputs originated from the substantia nigra and the ventral tegmental area. It has previously been shown that the lateral hypothalamus (LH) stimulation produces antinociception via orexinergic projections of the LH to the DG region. So ...
DOI:
10.1016/j.physbeh.2020.113214

8. Effects of caffeine on mating behavior and sperm precedence in Tribolium castaneum

Author:
Yuhao, Ji; Ryuji, Yuki; Matsumura, Kentarou; Miyatake, Takahisa
Source:
Ethology 2021 v.127 no.1 pp. 45-49
ISSN:
0179-1613
Subject:
dopamine; dopamine receptors,   etc   ; Tribolium castaneum; aedeagus; animal behavior; caffeine; insects; males; spermatozoa;     Show all 9 Subjects
Abstract:
... Biogenic amines such as dopamine are physiologically neuroactive substances that affect behavioral and physiological traits in invertebrates, and it has long been known that these substances affect mating behavior in insects. Caffeine is a dopamine activator and thus enhances dopamine receptor activity. However, the effects of caffeine intake on insect mating behavior have been largely unexplored. ...
DOI:
10.1111/eth.13094

9. Controlling receptor function from the extracellular vestibule of G-protein coupled receptors

Author:
Egyed, Attila; Domány-Kovács, Katalin; Koványi, Bence; Horti, Ferenc; Kurkó, Dalma; Kiss, Dóra Judit; Pándy-Szekeres, Gáspár; Greiner, István; Keserű, György M.
Source:
Chemical communications 2020 v.56 no.91 pp. 14167-14170
ISSN:
1364-548X
Subject:
dopamine,   etc   ; humans; ligands;     Show all 3 Subjects
Abstract:
... Receptor function is traditionally controlled from the orthosteric binding site of G-protein coupled receptors. Here, we show that the functional activity and signalling of human dopamine D2 and D3 receptor ligands can be fine-tuned from the extracellular secondary binding pocket (SBP) located far from the signalling interface suggesting optimization of the SBP binding part of bitopic ligands migh ...
DOI:
10.1039/d0cc05532h

10. Nanocage-confined electrochemiluminescence for the detection of dopamine released from living cells

Author:
Ding, Hao; Guo, Weiliang; Zhou, Ping; Su, Bin
Source:
Chemical communications 2020 v.56 no.59 pp. 8249-8252
ISSN:
1364-548X
Subject:
dopamine,   etc   ; chemical reactions; electrochemiluminescence;     Show all 3 Subjects
Abstract:
... Herein we report an electrochemiluminescent nanocage array (ENA) in which luminophores are physically confined. The ENA can function as a solid sensor for the detection of dopamine released from living cells on the basis of its quenching effect on the ECL signal. ...
DOI:
10.1039/d0cc03370g

11. An integrated wearable strain, temperature and humidity sensor for multifunctional monitoring

Author:
Bi, Siyi; Hou, Lei; Lu, Yinxiang
Source:
Composites 2021 v.149 pp. 106504
ISSN:
1359-835X
Subject:
dopamine,   etc   ; cost effectiveness; electronics; fabrics; flax; nickel; relative humidity; temperature;     Show all 8 Subjects
Abstract:
... Explosive growth in demand for wearable devices has promoted the development of smart materials with multifunctional performances. Flexible flax fabric (FF) coated with CNT and nickel serving as multifunctional sensor are prepared through a cost-effective dip-coating and electroless deposition technology. Biocompatible dopamine film self-polymerized on CNT surface effectively enhances the interfac ...
DOI:
10.1016/j.compositesa.2021.106504

12. Convincing Catalytic Performance of Oxo-Tethered Ruthenium Complexes for Asymmetric Transfer Hydrogenation of Cyclic α-Halogenated Ketones through Dynamic Kinetic Resolution

Author:
Touge, Taichiro; Nara, Hideki; Kida, Michio; Matsumura, Kazuhiko; Kayaki, Yoshihito
Source:
Organic letters 2021 v.23 no.8 pp. 3070-3075
ISSN:
1523-7052
Subject:
dopamine receptors,   etc   ; carboxamides; catalysts; catalytic activity; halogens; hydrogenation; ligands; ruthenium;     Show all 8 Subjects
Abstract:
... A highly efficient dynamic kinetic resolution of cyclic halohydrins was achieved by the asymmetric transfer hydrogenation of racemic α-haloketones. Bifunctional oxo-tethered Ru(II) catalysts could promote the reduction without deterioration of halogens. By structural tuning of the catalyst, chiral alcohols having halogen, ester, carboxamide, and sulfone functions were obtained variably with excell ...
DOI:
10.1021/acs.orglett.1c00739

13. Structures of the human dopamine D3 receptor-Gi complexes

Author:
Xu, Peiyu; Huang, Sijie; Mao, Chunyou; Krumm, Brian E.; Zhou, X. Edward; Tan, Yangxia; Huang, Xi-Ping; Liu, Yongfeng; Shen, Dan-Dan; Jiang, Yi; Yu, Xuekui; Jiang, Hualiang; Melcher, Karsten; Roth, Bryan L.; Cheng, Xi; Zhang, Yan; Xu, H. Eric
Source:
Molecular cell 2021 v.81 no.6 pp. 1147-1159.e4
ISSN:
1097-2765
Subject:
dopamine,   etc   ; agonists; central nervous system; humans; ligands; mutagenesis;     Show all 6 Subjects
Abstract:
... The dopamine system, including five dopamine receptors (D1R–D5R), plays essential roles in the central nervous system (CNS), and ligands that activate dopamine receptors have been used to treat many neuropsychiatric disorders. Here, we report two cryo-EM structures of human D3R in complex with an inhibitory G protein and bound to the D3R-selective agonists PD128907 and pramipexole, the latter of w ...
DOI:
10.1016/j.molcel.2021.01.003

14. Preparation of superhydrophobic nylon-56/cotton-interwoven fabric with dopamine-assisted use of thiol–ene click chemistry

Author:
Wang, Baoliang; Gao, Chengyong; Huang, Yiting; Xu, Zhenzhen; Zhang, Yanbo; Yang, Qianxue; Xing, Tieling; Chen, Guoqiang
Source:
RSC advances 2021 v.11 no.18 pp. 10699-10709
ISSN:
2046-2069
Subject:
dopamine,   etc   ; contact angle; fabrics; hydrophobicity; nylon; sustainable technology; ultraviolet radiation;     Show all 7 Subjects
Abstract:
... With the help of dopamine, we constructed a hydroxyl-rich secondary reaction platform on a surface formed by interwoven nylon 56 and cotton fibres. Octadecyl mercaptan and vinyl trimethoxysilane (VTMS) are used for the click coupling preparation of superhydrophobic reagents, which are grafted onto polydopamine aggregates and successfully used to prepare superhydrophobic nylon 56/cotton-interwoven ...
DOI:
10.1039/d1ra00410g

15. Roles of dopamine and glutamate co‐release in the nucleus accumbens in mediating the actions of drugs of abuse

Author:
Buck, Silas A.; Torregrossa, Mary M.; Logan, Ryan W.; Freyberg, Zachary
Source:
TheFEBS journal 2021 v.288 no.5 pp. 1462-1474
ISSN:
1742-464X
Subject:
dopamine,   etc   ; alcohols; cocaine; glutamic acid; narcotics; neurons; neurotransmitters;     Show all 7 Subjects
Abstract:
... Projections of ventral tegmental area dopamine (DA) neurons to the medial shell of the nucleus accumbens have been increasingly implicated as integral to the behavioral and physiological changes involved in the development of substance use disorders (SUDs). Recently, many of these nucleus accumbens‐projecting DA neurons were found to also release the neurotransmitter glutamate. This glutamate co‐r ...
DOI:
10.1111/febs.15496

16. Substantial Depletion of Vicine, Levodopa, and Tyramine in a Fava Bean Protein-Based Nutritional Product

Author:
Johns, Paul W.; Hertzler, Steven R.
Source:
International Journal of Food Sciences 2021 v.2021
ISSN:
2314-5765
Subject:
dopamine,   etc   ; L-dopa; faba beans; glycosides; liquids; protein isolates; tyramine;     Show all 7 Subjects
Abstract:
... A commercial fava bean protein isolate and a liquid nutritional product formulated with it were tested by validated HPLC methods for the favism-associated pyrimidine glycoside vicine, the dopamine precursor levodopa, and the biogenic amine tyramine. The vicine, levodopa, and tyramine concentrations in the protein isolate—306, 13.3, and <0.5 mg/kg, respectively—when expressed on a protein basis—34, ...
DOI:
10.1155/2021/6669544

17. In situ infrared spectroscopy of dopamine oxidation/reduction reactions on a polycrystalline boron-doped diamond electrode

Author:
Hosoda, Ryo; Kamoshida, Naoki; Hoshi, Nagahiro; Einaga, Yasuaki; Nakamura, Masashi
Source:
Carbon 2021 v.171 pp. 814-818
ISSN:
0008-6223
Subject:
dopamine,   etc   ; carbon; electrodes; hydroquinone; infrared spectroscopy; oxidation; polymerization; quinones;     Show all 8 Subjects
Abstract:
... The oxidation of dopamine (DA) on a boron-doped diamond (BDD) electrode was investigated using in situ attenuated total reflection infrared spectroscopy (ATR-IR) and infrared reflection absorption spectroscopy (IRAS). Voltammogram showed multiple anodic/cathodic peaks for the oxidation/reduction of DA and its oxidized derivatives on the BDD electrode. The oxidation/reduction species on the surface ...
DOI:
10.1016/j.carbon.2020.09.069

18. The Functional Vision Protection Effect of Danshensu via Dopamine D1 Receptors: In Vivo Study

Author:
Chen, Yun-Wen; Huang, Yun-Ping; Wu, Pei-Chang; Chiang, Wei-Yu; Wang, Ping-Hsun; Chen, Bo-Yie
Source:
Nutrients 2021 v.13 no.3
ISSN:
2072-6643
Subject:
dopamine; dopamine receptors,   etc   ; ; Salvia miltiorrhiza; antagonists; antioxidants; danshensu; energy; mice; nutritive value; protective effect; retina; retinal degeneration; vision;     Show all 14 Subjects
Abstract:
... Danshensu, a traditional herb-based active component (Salvia miltiorrhiza Bunge), has garnered attention, due to its safety, nutritional value, and antioxidant effects, along with cardiovascular-protective and neuroprotective abilities; however, its effect on the retinal tissues and functional vision has not been fully studied. The objective of this study was to analyze the protective effect of da ...
DOI:
10.3390/nu13030978

19. Structural insights into the human D1 and D2 dopamine receptor signaling complexes

Author:
Zhuang, Youwen; Xu, Peiyu; Mao, Chunyou; Wang, Lei; Krumm, Brian; Zhou, X. Edward; Huang, Sijie; Liu, Heng; Cheng, Xi; Huang, Xi-Ping; Shen, Dan-Dan; Xu, Tinghai; Liu, Yong-Feng; Wang, Yue; Guo, Jia; Jiang, Yi; Jiang, Hualiang; Melcher, Karsten; Roth, Bryan L.; Zhang, Yan; Zhang, Cheng; Xu, H. Eric
Source:
Cell 2021 v.184 no.4 pp. 931-942.e18
ISSN:
0092-8674
Subject:
dopamine; dopamine receptors,   etc   ; apomorphine; bromocriptine; central nervous system; cryo-electron microscopy; drug design; humans; ligands; mutagenesis; schizophrenia; therapeutics; topology;     Show all 13 Subjects
Abstract:
... The D1- and D2-dopamine receptors (D1R and D2R), which signal through Gₛ and Gᵢ, respectively, represent the principal stimulatory and inhibitory dopamine receptors in the central nervous system. D1R and D2R also represent the main therapeutic targets for Parkinson’s disease, schizophrenia, and many other neuropsychiatric disorders, and insight into their signaling is essential for understanding b ...
DOI:
10.1016/j.cell.2021.01.027

20. Association of blood lead level with neurobehavior and neurotransmitter expressions in Indian children

Author:
L., Malavika; Mitra, Prasenjit; Goyal, Taru; Abhilasha,; Sharma, Shailja; Purohit, Purvi; Sharma, Praveen
Source:
Toxicology reports 2021 v.8 pp. 971-976
ISSN:
2214-7500
Subject:
dopamine; dopamine receptors,   etc   ; atomic absorption spectrometry; blood serum; childhood; environmental exposure; genes; lead; neurotransmitters; quantitative polymerase chain reaction; serotonin; toxicology;     Show all 12 Subjects
Abstract:
... Present study aimed to assess the alterations in neurotransmitter expression and its association with Blood Lead Level (BLL) and neurobehavioral pattern in children. 72 school going children were recruited. Blood lead levels were determined by Atomic Absorption Spectrophotometer. Neurobehavioral state was assessed by means of population specific scale i.e. CPMS (Childhood Psychopathological measur ...
DOI:
10.1016/j.toxrep.2021.05.002