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1. An investigation into applicability of different compression behaviour assessment approaches for multiparticulate units characterization

Author:
Vasiljević, Ivana; Turković, Erna; Piller, Michael; Zimmer, Andreas; Parojčić, Jelena
Source:
Powder technology 2021 v.379 pp. 526-536
ISSN:
0032-5910
Subject:
drug formulations,   etc   ; behavior; classification; compressibility; drugs; extrusion; kneading; manufacturing; mixtures; research; spheronization;     Show all 11 Subjects
Abstract:
... Increasing expectations to understand material properties and process parameters impact on drug product performance resulted in increased efforts towards evaluation of drug/excipients mixtures, particularly during compression. Several research groups introduced material classification methodologies based on compression behaviour. In the present work, the applicability of different compression beha ...
DOI:
10.1016/j.powtec.2020.10.085

2. Graphite-polystyrene composite with enhanced electrochemical and electroanalytical performance

Author:
Surkov, Andrei M.; Queiroz, Rodrigo G.; Rinco, Rafael S.; Rios, Alejandro G.; Gutz, Ivano G.R.; Baccaro, Alexandre L.B.; Angnes, Lúcio
Source:
Talanta 2021 v.223 pp. 121780
ISSN:
0039-9140
Subject:
drug formulations,   etc   ; acetaminophen; acetone; chloroform; detection; electrochemistry; flow injection analysis; foams; glassy carbon electrode; graphene; mixing; particles; polystyrenes; shape; solvents;     Show all 15 Subjects
Abstract:
... A new composite electrode (G-PSE) was developed from graphite powder and expanded polystyrene (EPS, Styrofoam) by simply dissolving the foam in chloroform, incorporating the graphite particles under mixing and volatilizing the solvent at 80 °C. The resulting rigid black composite can be softened with acetone and so it can easily be molded to any shape, e.g., into a PTFE tube with an electric conta ...
DOI:
10.1016/j.talanta.2020.121780

3. Frequency analysis of stress relaxation patterns reveals the effect of formulation and process history on tablet disintegration

Author:
Tomas, Jan; Dvořák, Jakub; Dammer, Ondřej; Štěpánek, František
Source:
Powder technology 2021 v.379 pp. 438-446
ISSN:
0032-5910
Subject:
drug formulations,   etc   ; biopharmaceuticals; frequency; gastrointestinal system; granules; history; information; materials; measurement; monitoring; particle size; particles; stress relaxation; technology; texture;     Show all 15 Subjects
Abstract:
... Tablets are the most common pharmaceutical dosage form. Being compressed from smaller particles or granules, the disintegration rate of tablets in the gastro-intestinal tract is a key property that strongly influences the rate of drug release. While established methods for in vitro tablet disintegration measurement provide information about the final disintegration time, a more detailed analysis o ...
DOI:
10.1016/j.powtec.2020.10.081

4. Albumin-binding prodrugs via reversible iminoboronate forming nanoparticles for cancer drug delivery

Author:
Hao, Lingqiao; Zhou, Quan; Piao, Ying; Zhou, Zhuxian; Tang, Jianbin; Shen, Youqing
Source:
Journal of controlled release 2021 v.330 pp. 362-371
ISSN:
0168-3659
Subject:
drug formulations,   etc   ; antineoplastic agents; bovine serum albumin; chemical bonding; curcumin; cytosol; encapsulation; environment; glutathione; hydrophobicity; models; nanomedicine; nanoparticles; neoplasms; pharmacokinetics; protein binding;     Show all 16 Subjects
Abstract:
... Albumin-based nanomedicines are important nanoplatforms for cancer drug delivery. The drugs are either physically encapsulated or covalently conjugated to albumin or albumin-based nanosystems. Physical encapsulation is advantageous due to requiring no chemical modification of drug molecules, but many drugs, for instance, camptothecin (CPT) and curcumin (CCM), though very hydrophobic, can't be load ...
DOI:
10.1016/j.jconrel.2020.12.035

5. Bioactive potential of yak's milk and its products; pathophysiological and molecular role as an immune booster in antibiotic resistance

Author:
Kulyar, Muhammad Fakhar-e-Alam; Yao, Wangyuan; Ding, Yenmi; Li, Kun; Zhang, Lihong; Li, Aoyun; Waqas, Muhammad; Huachun, Pan; Quan, Mo; Zeng, Zhibo; Mehmood, Khalid; Sizhu, Suolang; Li, Jiakui
Source:
Food bioscience 2021 v.39 pp. 100838
ISSN:
2212-4292
Subject:
drug formulations,   etc   ; antibiotic resistance; bacteria; bioactive compounds; butyrophilin; cell adhesion molecules; gene expression regulation; genomics; human health; immune system; industrialization; information; milk; nutrition; pharmaceutical industry; scientists; strains; yaks;     Show all 18 Subjects
Abstract:
... Antibiotic resistance is one of the most serious health threats in the world. The emergence of resistant bacteria has seriously limited our ability to treat bacterial illness. So, the world is moving toward other ways of treatment. Scientists emphasis on nutrition to maintain human health to overcome such problems. Yak's milk is rich in bioactive constituents with an antagonistic activity that tri ...
DOI:
10.1016/j.fbio.2020.100838

6. Pulmonary surfactant and drug delivery: Vehiculization, release and targeting of surfactant/tacrolimus formulations

Author:
Hidalgo, Alberto; Garcia-Mouton, Cristina; Autilio, Chiara; Carravilla, Pablo; Orellana, Guillermo; Islam, Mohammad N.; Bhattacharya, Jahar; Bhattacharya, Sunita; Cruz, Antonio; Pérez-Gil, Jesús
Source:
Journal of controlled release 2021 v.329 pp. 205-222
ISSN:
0168-3659
Subject:
drug formulations,   etc   ; animal models; anti-inflammatory activity; anti-inflammatory agents; hydrophobicity; in vitro studies; lipopolysaccharides; liquid-air interface; lungs; mice; proteins; surfactants; swine; tacrolimus;     Show all 14 Subjects
Abstract:
... This work explores the potential for strategizing pulmonary surfactant (PS) for drug delivery over the respiratory air-liquid interface: the interfacial delivery. The efficacy of PS- and interface-assisted drug vehiculization was determined both in vitro and in vivo using a native purified porcine PS combined with the hydrophobic anti-inflammatory drug Tacrolimus (TAC), a calcineurin inhibitor. In ...
DOI:
10.1016/j.jconrel.2020.11.042

7. Sample Enrichment of Canagliflozin Prior to Its Spectrophotometric Determination in Presence of Metformin: Application to Recently Approved Binary Dosage Form

Author:
Wafaa A. Zaghary,; Mowaka, Shereen; Hendy, Moataz S.
Source:
Journal of analytical chemistry 2020 v.75 no.6 pp. 742-753
ISSN:
1061-9348
Subject:
drug formulations,   etc   ; analytical chemistry; metformin;     Show all 3 Subjects
Abstract:
... This work illustrates four different spectrophotometric methods for metformin (MET) and canagliflozin (CANA) quantification in their recently approved pharmaceutical with trade name Invokamet®. The proposed methods are simple, definitive and accurate. Certain ensuing steps implementing zero spectra and/or ratio and/or derivative spectra were applied. Via implementing spectrum subtraction method ac ...
DOI:
10.1134/S1061934820060180

8. Glargine insulin loaded lipid nanoparticles: Oral delivery of liquid and solid oral dosage forms

Author:
Muntoni, Elisabetta; Anfossi, Laura; Milla, Paola; Marini, Elisabetta; Ferraris, Chiara; Capucchio, Maria T.; Colombino, Elena; Segale, Lorena; Porta, Massimo; Battaglia, Luigi
Source:
Nutrition, metabolism, and cardiovascular diseases 2021 v.31 no.2 pp. 691-698
ISSN:
0939-4753
Subject:
drug formulations,   etc   ; animal models; cardiovascular diseases; degradation; digestive system; enzymes; freeze drying; glucose; glycemic effect; humans; hyperinsulinemia; insulin; intestinal absorption; lipids; liquids; metabolism; nanoparticles; nutrition; oral administration; peptides; rats; research; shelf life; spray drying; suspensions;     Show all 25 Subjects
Abstract:
... The oral administration of insulin has so far been precluded by gastro-intestinal enzyme degradation and poor intestinal absorption. Preliminary evidence for peptide uptake by the gut has recently been obtained, by our research group, following the administration of nanostructured lipid-carrier suspensions loaded with glargine insulin in healthy animal models.In this experimental study, glargine i ...
DOI:
10.1016/j.numecd.2020.09.020

9. Gold nanoparticles capped with polysaccharides extracted from pineapple gum: Evaluation of their hemocompatibility and electrochemical sensing properties

Author:
Lopes, Luma Clarindo; Lima, Dhésmon; Mendes Hacke, Ana Carolina; Schveigert, Bianca Siqueira; Calaça, Giselle Nathaly; Simas, Fernanda Fogagnoli; Pereira, Romaiana Picada; Iacomini, Marcello; Viana, Adriano Gonçalves; Pessôa, Christiana Andrade
Source:
Talanta 2021 v.223 pp. 121634
ISSN:
0039-9140
Subject:
drug formulations,   etc   ; accuracy; antihistamines; assays; behavior; biocompatibility; carbon; design; detection; diameter; dielectric spectroscopy; electrical conductivity; electrochemistry; erythrocytes; experimental design; glassy carbon electrode; leukocytes; nanogold; nanoparticles; pH; pineapples; polysaccharides; precision; sensors (equipment); surface area; toxicity; voltammetry; zeta potential;     Show all 28 Subjects
Abstract:
... In the present work, gold nanoparticles were synthesized through a green route by using, for the first time, polysaccharides extracted from pineapple gum (PG) as the reducing and capping agent. The obtained nanoparticles (AuNPs-PG) were characterized by UV-VIS, FTIR, TEM, FESEM, EDX, XRD, and zeta potential measurements, which confirmed that PG was effective to produce AuNPs with an average diamet ...
DOI:
10.1016/j.talanta.2020.121634

10. Withania somnifera (L.) Dunal - Modern perspectives of an ancient Rasayana from Ayurveda

Author:
Mukherjee, Pulok K.; Banerjee, Subhadip; Biswas, Sayan; Das, Bhaskar; Kar, Amit; Katiyar, C.K.
Source:
Journal of ethnopharmacology 2021 v.264 pp. 113157
ISSN:
0378-8741
Subject:
drug formulations,   etc   ; Ayurvedic medicine; Withania somnifera; alkaloids; anxiety; bioactive compounds; chemical constituents of plants; clinical trials; databases; drugs; flavonoids; information sources; mechanism of action; medicinal plants; medicinal properties; plant extracts; saponins; tannins; taxon descriptions;     Show all 19 Subjects
Abstract:
... Withania somnifera (L.) Dunal, commonly known as Ashwagandha, is an important medicinal plant that has been used in Ayurvedic and indigenous medicine for more than 3000 years. According to Charaka Samhita, Susruta Samhita and other ancient texts, Ashwagandha is known as Balya (increases strength), Brusya (sexual performance enhancer), vajikari (spermatogenic), Kamarupini (libido-enhancing), Pustid ...
DOI:
10.1016/j.jep.2020.113157

11. A first principle model for simulating the ribbon solid fraction during pharmaceutical roller compaction process

Author:
Amini, Hossein; Akseli, Ilgaz
Source:
Powder technology 2020 v.368 pp. 32-44
ISSN:
0032-5910
Subject:
drug formulations,   etc   ; equations; intermediate product; model validation; prediction;     Show all 5 Subjects
Abstract:
... Solid fraction is a key intermediate product attribute which significantly affects the granule characteristics prepared in a roller compaction (RC) process. Implementing the quality by design (QbD) in pharmaceutical manufacturing requires quantitative insight into the impacts of process parameters and material properties on product attributes. Despite the efforts made towards modeling of RC proces ...
DOI:
10.1016/j.powtec.2020.04.022

12. Natural polysaccharides for controlled delivery of oral therapeutics: a recent update

Author:
Layek, Buddhadev; Mandal, Sanchita
Source:
Carbohydrate polymers 2020 v.230 pp. 115617
ISSN:
0144-8617
Subject:
drug formulations,   etc   ; biocompatibility; biodegradability; drugs; polysaccharides; renewable resources; therapeutics;     Show all 7 Subjects
Abstract:
... Oral controlled release formulations have been at the center of pharmaceutical research over several decades due to their distinct advantages compared to conventional dosage forms where the entire drug payload is released and absorbed rapidly following administration. Natural polysaccharides are extensively being studied as release modifiers in oral controlled release dosage forms because of their ...
DOI:
10.1016/j.carbpol.2019.115617

13. Pickering emulsions: Preparation processes, key parameters governing their properties and potential for pharmaceutical applications

Author:
Albert, Claire; Beladjine, Mohamed; Tsapis, Nicolas; Fattal, Elias; Agnely, Florence; Huang, Nicolas
Source:
Journal of controlled release 2019 v.309 pp. 302-332
ISSN:
0168-3659
Subject:
drug formulations,   etc   ; droplet size; emulsions;     Show all 3 Subjects
Abstract:
... An increased interest in Pickering emulsions has emerged over the last 15 years, mainly related to their very attractive properties compared to regular emulsions, namely their excellent stability and their numerous possible applications. In this review, after detailing the interest of Pickering emulsions, their main preparation processes are presented and their advantages and disadvantages discuss ...
DOI:
10.1016/j.jconrel.2019.07.003

14. The EsoCap-system – An innovative platform to drug targeting in the esophagus

Author:
Krause, Julius; Rosenbaum, Christoph; Grimm, Michael; Rump, Adrian; Keßler, Rebecca; Hosten, Norbert; Weitschies, Werner
Source:
Journal of controlled release 2020 v.327 pp. 1-7
ISSN:
0168-3659
Subject:
drug formulations,   etc   ; digestive tract mucosa; drugs; esophageal diseases; esophagus; therapeutics; volunteers;     Show all 7 Subjects
Abstract:
... For the therapy of esophageal diseases such as eosinophilic esophagitis, there are no possibilities of local targeted therapy. This publication describes a novel, innovative drug delivery concept, that enables a targeted, long-lasting administration of drug substances to the esophageal mucosa. In addition to a comprehensive in-vitro characterization of the dosage form, this work includes a proof-o ...
DOI:
10.1016/j.jconrel.2020.08.011

15. In-Hospital Production of Medicines: Preparing for Disruption

Author:
Kalkman, Shona; Arentshorst, Marlous; Hoekman, Jarno; Boon, Wouter; Uijtendaal, Esther; van Thiel, Ghislaine; Moors, Ellen
Source:
Trends in biotechnology 2020 v.38 no.10 pp. 1045-1047
ISSN:
0167-7799
Subject:
drug formulations,   etc   ; cost effectiveness; drugs; ethics; hospitals; laws and regulations; Netherlands;     Show all 7 Subjects
Abstract:
... In-hospital production of affordable medicines holds potential to address problems of drug accessibility. However, expanding the scope of magistral preparation to include high-cost drugs and complex biologicals gives rise to new challenges. We discuss ethical and regulatory complexities faced by Dutch initiatives defying the current pharmaceutical system through magistral preparation. ...
DOI:
10.1016/j.tibtech.2019.09.011

16. Production, partial purification and characterization of a proteoglycan bioemulsifier from an oleaginous yeast

Author:
Bhaumik, Moumita; Dhanarajan, Gunaseelan; Chopra, Jayita; Kumar, RaviRanjan; Hazra, Chinmay; Sen, Ramkrishna
Source:
Bioprocess and biosystems engineering 2020 v.43 no.10 pp. 1747-1759
ISSN:
1615-7591
Subject:
drug formulations,   etc   ; Meyerozyma caribbica; bioprocessing; cosmetics; emulsifiers; emulsifying; emulsions; engineering; glucose; pH; proteoglycans; salinity; temperature; yeasts;     Show all 14 Subjects
Abstract:
... In this study, Meyerozyma caribbica, an indigenously isolated oleaginous yeast, produced in media containing glucose a bioemulsifier that was partially characterized as a proteoglycan based on preliminary analysis. Optimization of carbon:nitrogen (C:N) ratio revealed 30:1 as the suitable ratio for enhanced production. Apart from higher emulsification activity (E₂₄: 70–80%), this molecule showed st ...
DOI:
10.1007/s00449-020-02361-1

17. Mechanistic understanding of underperforming enteric coated products: Opportunities to add clinical relevance to the dissolution test

Author:
Amaral Silva, Daniela; Davies, Neal M.; Doschak, Michael R.; Al-Gousous, Jozef; Bou-Chacra, Nadia; Löbenberg, Raimar
Source:
Journal of controlled release 2020 v.325 pp. 323-334
ISSN:
0168-3659
Subject:
drug formulations,   etc   ; bicarbonates; buffering capacity; buffers; drugs; intestines; markets; pH; phosphates; quality control;     Show all 10 Subjects
Abstract:
... Over the last 70 years several cases of in vivo failure of enteric coated (EC) formulations have been reported. The observed failures seem to be due to the slower than expected in vivo performance of EC products. Upon reaching the intestinal lumen, the dosage form is exposed to a bicarbonate buffered environment at much lower interfacial buffering capacity compared to those applied in compendial p ...
DOI:
10.1016/j.jconrel.2020.06.031

18. Oxidized konjac glucomannan-cassava starch and sucrose esters as novel excipients for sustained-release matrix tablets

Author:
Liu, Cancan; Li, Jianbin; Li, Kai; Xie, Caifeng; Liu, Jidong
Source:
International journal of biological macromolecules 2020 v.156 pp. 1045-1052
ISSN:
0141-8130
Subject:
drug formulations,   etc   ; Amorphophallus; adjuvants; cassava; drugs; heat; oxidation; porosity; solubility; starch; sucrose esters; swelling (materials);     Show all 12 Subjects
Abstract:
... A novel sustained-release matrix tablet was developed through wet granulation by using oxidized konjac glucomannan-cassava starch (OKGM-CS) and sucrose esters (SE) as excipients. OKGM-CS treated by dry heat exhibited low solubility and swelling power, indicating that it might be a potential adjuvant for sustained-release drug formulations. SE incorporation significantly decreased the porosity and ...
DOI:
10.1016/j.ijbiomac.2019.11.146

19. Application of star poly(ethylene glycol) derivatives in drug delivery and controlled release

Author:
Zhao, Xiaobao; Si, Jingxing; Huang, Dongsheng; Li, Ke; Xin, Ying; Sui, Meihua
Source:
Journal of controlled release 2020 v.323 pp. 565-577
ISSN:
0168-3659
Subject:
drug formulations,   etc   ; blood circulation; crosslinking; drug delivery systems; drugs; hydrogels; micelles; polyethylene glycol;     Show all 8 Subjects
Abstract:
... Multi-arm star poly(ethylene glycol) (PEG) polymers have a number of advantages over linear PEG polymers when used as carriers for drug delivery and controlled release. For instance, they have more terminals that can be modified to form multi-functional delivery systems with significantly increased drug loading. They can form micelles with higher stability and lower critical micelle concentration ...
DOI:
10.1016/j.jconrel.2020.04.039

20. Evaluation of the analytical performances of two Raman handheld spectrophotometers for pharmaceutical solid dosage form quantitation

Author:
Coic, Laureen; Sacré, Pierre-Yves; Dispas, Amandine; Dumont, Elodie; Horne, Julie; De Bleye, Charlotte; Fillet, Marianne; Hubert, Philippe; Ziemons, Eric
Source:
Talanta 2020 v.214 pp. 120888
ISSN:
0039-9140
Subject:
drug formulations,   etc   ; active pharmaceutical ingredients; case studies; models; prediction; representative sampling; spectrophotometers;     Show all 7 Subjects
Abstract:
... This paper addresses the issue of pharmaceutical solid dosage form quantitation using handheld Raman spectrophotometers. The two spectrophotometers used are designed with different technologies: one allows getting a more representative sampling with the Orbital Raster Scanning technology and the other one allows setting acquisition parameters. The goal was to evaluate which technology could provid ...
DOI:
10.1016/j.talanta.2020.120888