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1. Synthesis and application of PEGylated tracer particles for measuring protein solution viscosities using Dynamic Light Scattering-based microrheology

Author:
Garting, Tommy; Stradner, Anna
Source:
Colloids and surfaces 2019 v.181 pp. 516-523
ISSN:
0927-7765
Subject:
drug formulations,   etc   ; light scattering; rheology; viscosity;     Show all 4 Subjects
Abstract:
... The measurement of flow properties, such as the zero shear viscosity, of protein solutions is of paramount importance for many applications such as pharmaceutical formulations, where the syringeability of physiologically effective doses is a key property. However, the determination of these properties with classical rheological methods is often challenging due to e.g. detrimental surface effects o ...
DOI:
10.1016/j.colsurfb.2019.05.059

2. Modified-release topical hydrogels: a ten-year review

Author:
Croisfelt, Fernanda Machado; Tundisi, Louise Lacalendola; Ataide, Janaína Artem; Silveira, Edgar; Tambourgi, Elias Basile; Jozala, Angela Faustino; Souto, Eliana Maria Barbosa; Mazzola, Priscila Gava
Source:
Journal of materials science 2019 v.54 no.16 pp. 10963-10983
ISSN:
0022-2461
Subject:
drug formulations,   etc   ; hydrogels; ingredients; polymers; raw materials;     Show all 5 Subjects
Abstract:
... Hydrogels are polymeric networks with tridimensional structure, which are able to load water and other substances. Such property makes hydrogels suitable for innumerous applications in biomedical field. Hydrogels are being used as raw materials in pharmaceutical formulations for more than 60 years, while significant progress is very well documented in topical use. Natural and synthetic polymers ha ...
DOI:
10.1007/s10853-019-03557-x

3. An LDI-MSI approach for targeted and untargeted differentiation and assessment of pharmaceutical formulations

Author:
Falco, Luís Fernando Godoy; Melo, Carlos Fernando Odir Rodrigues; de Oliveira, Diogo Noin; Guerreiro, Tatiane Melina; Catharino, Rodrigo Ramos
Source:
Talanta 2019 v.197 pp. 92-97
ISSN:
0039-9140
Subject:
drug formulations,   etc   ; byproducts; desorption; drugs; ionization; screening;     Show all 6 Subjects
Abstract:
... Falsified, counterfeit and adulterated medicines are an endemic problem worldwide that results in both monetary and health-related losses. Developing fast and reliable methods that are able to present a timely result based on the drug's spectral profile is an effort that is sure to benefit those involved in the whole distribution chain. We propose herein a Laser Desorption/Ionization imaging-based ...
DOI:
10.1016/j.talanta.2018.12.044

4. Human chorionic gonadotrophin pharmaceutical formulations of urinary origin display high levels of contaminant proteins–A label‐free quantitation proteomics study

Author:
Panić‐Janković, Tanja; Mitulović, Goran
Source:
Electrophoresis 2019 v.40 no.11 pp. 1622-1629
ISSN:
0173-0835
Subject:
drug formulations,   etc   ; active ingredients; electrophoresis; human chorionic gonadotropin; proteins; proteomics;     Show all 6 Subjects
Abstract:
... To determine whether there is a measurable protein background in different formulations of urinary and recombinant human chorionic gonadotropin (hCG). Primary outcome measures: identification of contaminant proteins in urinary‐derived formulations of hCG; secondary outcome measures: quantitative values of contaminant proteins in different batches of urinary –derived hCG formulations. It was found ...
DOI:
10.1002/elps.201900087

5. Chemical and pharmacological comparison of modern and traditional dosage forms of Joshanda

Author:
Parveen, Sajida; Irfan Bukhari, Nadeem; Shehzadi, Naureen; Qamar, Shaista; Ali, Ejaz; Naheed, Surriya; Latif, Abida; Yuchi, Alamgeer; Hussain, Khalid
Source:
Natural product research 2019 v.33 no.6 pp. 858-861
ISSN:
1478-6427
Subject:
drug formulations,   etc   ; antibacterial properties; chromatography; medicinal properties; metabolome; spectroscopy;     Show all 6 Subjects
Abstract:
... Recently, a traditional remedy (Joshanda) has been replaced largely by modern ready-to-use dosage forms, which have not been compared to the original remedy. Therefore, the present study aimed to compare a number of modern dosage forms with traditional remedy. Seven brands, 3 batches each, were compared with a Lab-made formulation with reference to analytical (proximate analyses, spectroscopic and ...
DOI:
10.1080/14786419.2017.1408103

6. Correction to: Determination of Menbutone in Bovine Milk and Meat Using Micellar Liquid Chromatography: Application to Injectable Dosage Forms

Author:
Belal, F.; Abd El-Razeq, SawsanA.; Fouad, ManalM.; Zayed, S.; Fouad, FatmaA.
Source:
Food analytical methods 2018 v.11 no.5 pp. 1541
ISSN:
1936-9751
Subject:
drug formulations,   etc   ; liquid chromatography; meat; milk;     Show all 4 Subjects
Abstract:
... The original version of this article unfortunately contained a mistake. Affiliation 4 should be included for Manal M. Fouad. ...
DOI:
10.1007/s12161-017-1120-y

7. Flow-Injection Spectrophotometric Determination of Methimazole in Pharmaceuticals Using a Charge Transfer Complex Cu(I)‒Neocuproine

Author:
da Silva, JeannCarlos; Suarez, WillianToito; de Oliveira Krambeck Franco, Mathews
Source:
Journal of analytical chemistry 2018 v.73 no.3 pp. 243-248
ISSN:
1061-9348
Subject:
drug formulations,   etc   ; copper; drugs; solvents; statistical analysis;     Show all 5 Subjects
Abstract:
... In this work an accurate, fast and high throughput flow procedure was developed in order to determine methimazole in pharmaceutical formulations. The method is based on reduction of Cu(II) to Cu(I) by methimazole in the presence of 2,9-dimethyl-1,10-phenanthroline (neocuproine), followed by the generating a yellow charge-transfer complex that was spectrophotometrically monitored at 455 nm. The met ...
DOI:
10.1134/S1061934818030061

8. Understanding lipopolysaccharide aggregation and its influence on activation of Factor C

Author:
Wang, Chenxuan; Nelson, Travis; Chen, Dayue; Ellis, Joseph Christopher; Abbott, Nicholas L.
Source:
Journal of colloid and interface science 2019 v.552 pp. 540-553
ISSN:
0021-9797
Subject:
drug formulations,   etc   ; Limulus; aqueous solutions; bacteria; blood; light scattering; lipopolysaccharides; nonionic surfactants; salts;     Show all 9 Subjects
Abstract:
... The quantification of lipopolysaccharide (LPS) shed by bacteria within aqueous samples is typically performed by binding LPS to a protein called Factor C within a lysate prepared from the blood of horseshoe crabs (Limulus amebocyte lysate (LAL)). How the state of aggregation of LPS impacts Factor C activation, however, is not understood, particularly in the presence of select salts and non-ionic s ...
DOI:
10.1016/j.jcis.2019.05.013

9. Which is the best food emerging solvent: IL, DES or NADES?

Author:
Benvenutti, Laís; Zielinski, Acácio Antonio Ferreira; Ferreira, Sandra Regina Salvador
Source:
Trends in food science & technology 2019 v.90 pp. 133-146
ISSN:
0924-2244
Subject:
drug formulations,   etc   ; bioactive compounds; energy use and consumption; ionic liquids; polymers; raw materials; solvation; toxicity;     Show all 8 Subjects
Abstract:
... Bioactive compounds have been intensely studied because of their biological properties that provide health benefits. However, for chemical or biological applications, these compounds are obtained mostly by using organic solvents. Emergent technologies consider the combination of methods and process optimization to improve the utilization of raw material, decreasing process costs, time and energy c ...
DOI:
10.1016/j.tifs.2019.06.003

10. Membranes for dehydration of alcohols via pervaporation

Author:
Jyothi, M.S.; Reddy, Kakarla Raghava; Soontarapa, K.; Naveen, S.; Raghu, Anjanapura V.; Kulkarni, Raghavendra V.; Suhas, D.P.; Shetti, Nagaraj P.; Nadagouda, Mallikarjuna N.; Aminabhavi, Tejraj M.
Source:
Journal of environmental management 2019 v.242 pp. 415-429
ISSN:
0301-4797
Subject:
drug formulations,   etc   ; artificial membranes; carcinogenicity; chemical industry; distillation; energy; industrial applications; pervaporation;     Show all 8 Subjects
Abstract:
... Alcohols are the essential chemicals used in a variety of pharmaceutical and chemical industries. The extreme purity of alcohols in many of such industrial applications is essential. Though distillation is one of the methods used conventionally to purify alcohols, the method consumes more energy and requires carcinogenic entertainers, making the process environmentally toxic. Alternatively, effort ...
DOI:
10.1016/j.jenvman.2019.04.043

11. Pre-blocked molecular shuttle as an in-situ real-time theranostics

Author:
Sun, Tao; Zhang, Guangping; Wang, Qingbing; Guo, Zhongyuan; Chen, Qinjun; Chen, Xinli; Lu, Yifei; Zhang, Yu; Zhang, Yujie; Guo, Qin; Gao, Xiang; Cheng, Yongzhong; Jiang, Chen
Source:
Biomaterials 2019 v.204 pp. 46-58
ISSN:
0142-9612
Subject:
drug formulations,   etc   ; adverse effects; breast neoplasms; drugs; dyes; image analysis; near-infrared spectroscopy; peptides; precision medicine;     Show all 9 Subjects
Abstract:
... Real-time monitor of drug-release from drug formulations in a noninvasive way can provide spatio-temporal information for drug activation and guide further clinical rational administration. In this work, a molecular shuttle, as a typical nanosized artificial molecular machine, was managed to act as a conceptually-new nanotheranostics for oxaliplatin. A post-recognition strategy was utilized, where ...
DOI:
10.1016/j.biomaterials.2019.02.019

12. In Situ Quantification of Polysorbate in Pharmaceutical Samples of Therapeutic Proteins by Hydrodynamic Profiling by NMR Spectroscopy

Author:
Poppe, Leszek; Knutson, Nicholas; Cao, Shawn; Wikström, Mats
Source:
Analytical chemistry 2019 v.91 no.12 pp. 7807-7811
ISSN:
1520-6882
Subject:
drug formulations,   etc   ; antibodies; biopharmaceuticals; hydrodynamics; nonionic surfactants; nuclear magnetic resonance spectroscopy; polysorbates; sucrose; therapeutics; Jordan;     Show all 10 Subjects
Abstract:
... Polysorbates are nonionic surfactants often used at variable levels in various formulations of protein therapeutics. Their quantification in pharmaceutical samples has posed an analytical challenge. Here we present an approach based on ¹H NMR spectroscopy which can accurately estimate the concentration of polysorbate 80 (PS80) in intact pharmaceutical samples of an arbitrary formulation. The metho ...
DOI:
10.1021/acs.analchem.9b01442

13. Development and Validation of Analytical Method for Simultaneous Estimation of Tazarotene and Hydroquinone in their Gel Formulation by Reversed-phase High Performance Liquid Chromatography

Author:
Yadav Rajkumar,; Divya, Yadav; Rakesh, Yadav
Source:
Journal of analytical chemistry 2019 v.74 no.5 pp. 467-471
ISSN:
1061-9348
Subject:
drug formulations,   etc   ; detection limit; gels; guidelines; hydroquinone; reversed-phase high performance liquid chromatography;     Show all 6 Subjects
Abstract:
... A simple, sensitive, rapid, precise and accurate method has been developed for simultaneous estimation of tazarotene and hydroquinone in their pharmaceutical dosage form (gel preparation). The chromatographic separation was carried out on a reversed-phase Inertsil C18 (4.6 mm I.D. × 250 mm, 5 μm) column using a mobile phase consisting of 0.02 M KH₂PO₄‒acetonitrile (80 : 20, v/v) at a flow rate of ...
DOI:
10.1134/S1061934819050095

14. Three-Dimensional NMR Spectroscopy of Fluorinated Pharmaceutical Solids under Ultrafast Magic Angle Spinning

Author:
Lu, Xingyu; Skomski, Daniel; Thompson, Karen C.; McNevin, Michael J.; Xu, Wei; Su, Yongchao
Source:
Analytical chemistry 2019 v.91 no.9 pp. 6217-6224
ISSN:
1520-6882
Subject:
drug formulations,   etc   ; active pharmaceutical ingredients; drugs; fluorine; nuclear magnetic resonance spectroscopy; spinning; stable isotopes;     Show all 7 Subjects
Abstract:
... High-resolution solid-state analysis of multicomponent molecular systems, e.g., pharmaceutical formulations, is a great challenge. Solid-state nuclear magnetic resonance (ssNMR) spectroscopy plays a critical role in the characterization of solid dosage forms due to its capabilities of chemical identification, quantification, and structural elucidation at a molecular level. However, the low NMR sen ...
DOI:
10.1021/acs.analchem.9b00884

15. Voltammetric study and electroanalytical determination of contraceptive levonorgestrel using silver solid amalgam electrode fabricated with nanoparticles

Author:
de Souza, Ana Maria Braga; Fogliato, Daniela Kárin; Petroni, Jacqueline Marques; Ferreira, Valdir Souza; Lucca, Bruno Gabriel
Source:
International journal of environmental analytical chemistry 2019 v.99 no.5 pp. 397-408
ISSN:
1029-0397
Subject:
drug formulations,   etc   ; buffers; contraceptives; electrochemistry; electrodes; electrons; nanoparticles; nanosilver; pH; protons; silver; toxicity; urine;     Show all 13 Subjects
Abstract:
... Here we describe the investigation of the electrochemical behaviour and the electroanalytical quantification of hormonal contraceptive levonorgestrel using solid amalgam electrode fabricated with silver nanoparticles. Until now, to the best of our knowledge, this is the first report of the use of solid working electrodes for levonorgestrel determination. Over this electrodic surface, the substance ...
DOI:
10.1080/03067319.2019.1597870

16. Simultaneous voltammetric determination of acetaminophen and isoniazid using MXene modified screen-printed electrode

Author:
Zhang, Yu; Jiang, Xiantao; Zhang, Junjie; Zhang, Han; Li, Yingchun
Source:
Biosensors & bioelectronics 2019 v.130 pp. 315-321
ISSN:
0956-5663
Subject:
drug formulations,   etc   ; acetaminophen; biosensors; electrodes; hepatotoxicity; isoniazid; liver; oxidation; sulfuric acid;     Show all 9 Subjects
Abstract:
... Determination of hepatotoxic drugs is critical for both clinical diagnosis and quantity control of their pharmaceutical formulations. In this work, a facile and sensitive sensor based on MXene modified screen-printed electrode (MXene/SPE) has been developed for detection of acetaminophen (ACOP) and isoniazid (INZ), which are two commonly used drugs but might induce liver damage in certain circumst ...
DOI:
10.1016/j.bios.2019.01.043

17. The use of microtomographic imaging in the identification of counterfeit medicines

Author:
Wilczyński, Sławomir; Koprowski, Robert; Stolecka-Warzecha, Anna; Duda, Piotr; Deda, Anna; Ivanova, Diana; Kiselova-Kaneva, Yoana; Błońska-Fajfrowska, Barbara
Source:
Talanta 2019 v.195 pp. 870-875
ISSN:
0039-9140
Subject:
drug formulations,   etc   ; World Health Organization; chemical analysis; drugs; equipment; image analysis; micro-computed tomography;     Show all 7 Subjects
Abstract:
... The practice of drug counterfeiting is an important challenge due to the extremely rapid growth rate of this disturbing trend and its immense potential harmfulness. According to WHO even 10% of counterfeit medicines can be exact copies of genuine medicines: they have exactly the same quantitative and qualitative composition in terms of both API and excipients. Thus, the identification of such drug ...
DOI:
10.1016/j.talanta.2018.12.009

18. Liquisolid systems: Understanding the impact of drug state (solution or dispersion), nonvolatile solvent and coating material on simvastatin apparent aqueous solubility and flowability

Author:
Anzilaggo, Daiane; O’Reilly Beringhs, André; Pezzini, Bianca Ramos; Sonaglio, Diva; Stulzer, Hellen Karine
Source:
Colloids and surfaces 2019 v.175 pp. 36-43
ISSN:
0927-7765
Subject:
drug formulations,   etc   ; absorption; coatings; colloids; drugs; gastrointestinal system; manufacturing; solubility; solvents;     Show all 9 Subjects
Abstract:
... The drug in a solid dosage form must undergo dissolution before it is available for absorption from the gastrointestinal tract. Liquisolid system (LS) is a technology used for increasing aqueous solubility of the drugs, which has an important role in the dissolution and absorption phenomena. However, many factors can influence the performance and success of LS. Therefore this study aimed to evalua ...
DOI:
10.1016/j.colsurfb.2018.11.044

19. Effects of crushed Schisandra Fruit on the content of lignans in Kampo decoction

Author:
Atsumi, Toshiyuki; Yokoyama, Yumi; Yokogawa, Takami; Makino, Toshiaki; Ohtsuka, Isao
Source:
Natural medicines 2019 v.73 no.2 pp. 381-387
ISSN:
1340-3443
Subject:
drug formulations,   etc   ; Schisandra chinensis; crushing; drugs; fruits; lignans; medicine; quality control; seeds; taste;     Show all 10 Subjects
Abstract:
... Arboreous fruit of Schisandra chinensis Baillon, Schisandra Fruit (SF), is a crude drug used in Japanese traditional Kampo medicine. The marker compounds of SF for quality control are lignans, such as schizandrin (Sz) and gomisin A (GmA). Kampo formulation containing SF is usually prepared as decoctions in the dosage form of whole crude drug (W), as its size is small enough to measure using a spoo ...
DOI:
10.1007/s11418-018-1271-1

20. Analyzing Drug Release Kinetics from Water-Soluble Polymers

Author:
Kelly, Sean M.; Upadhyay, Arun K.; Mitra, Akash; Narasimhan, Balaji
Source:
Industrial & engineering chemistry process design and development 2019 v.58 no.18 pp. 7428-7437
ISSN:
1520-5045
Subject:
drug formulations,   etc   ; diclofenac; diffusivity; gels; illicit drugs; mathematical models; polymers; prediction; therapeutics; water solubility;     Show all 10 Subjects
Abstract:
... The ability to develop predictive mathematical models of therapeutic release from pharmaceutical formulations has enormous potential to enhance our understanding of such systems and improve the controlled release of the payload. The current work describes the development and testing of a one-dimensional model of drug transport from amorphous, swelling/dissolving polymers. Model parameters, such as ...
DOI:
10.1021/acs.iecr.8b05800