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1. Co-occurrence of genes for antibiotic resistance and arsenic biotransformation in paddy soils

Author:
Huiling Cui; Dong Zhu; Longjun Ding; Yifei Wang; Jianqiang Su; Guilan Duan; Yongguan Zhu
Source:
Journal of environmental sciences (China) 2023 v.125 pp. 701-711
ISSN:
1001-0742
Subject:
multiple drug resistance,   etc   ; Clostridium; antibiotic resistance; biotransformation; food safety; manure amendments; manure spreading; methylation; paddies; paddy soils; pollution; quantitative polymerase chain reaction; risk; China;     Show all 14 Subjects
Abstract:
... Paddy soils are potential hotspots of combined contamination with arsenic (As) and antibiotics, which may induce co-selection of antibiotic resistance genes (ARGs) and As biotransformation genes (ABGs), resulting in dissemination of antimicrobial resistance and modification in As biogeochemical cycling. So far, little information is available for these co-selection processes and specific patterns ...
DOI:
10.1016/j.jes.2022.02.027

2. Expression of concern: Upregulation of lncRNA SUMO1P3 promotes proliferation, invasion and drug resistance in gastric cancer through interacting with the CNBP protein

Author:
Laura Fisher
Source:
RSC advances 2022 v.12 no.8 pp. 4572
ISSN:
2046-2069
Subject:
drug resistance,   etc   ; proteins; stomach neoplasms;     Show all 3 Subjects
Abstract:
... Expression of concern for ‘Upregulation of lncRNA SUMO1P3 promotes proliferation, invasion and drug resistance in gastric cancer through interacting with the CNBP protein’ by Yinmou Guo et al., RSC Adv., 2020, 10, 6006–6016, DOI: 10.1039/C9RA09497K. ...
DOI:
10.1039/d2ra90005j

3. Recurrences of multidrug‐resistant tuberculosis: Strains involved, within‐host diversity, and fine‐tuned allocation of reinfections

Author:
Laura Pérez‐Lago; Johana Monteserin; Roxana Paul; Sandra R. Maus; Noemí Yokobori; Marta Herranz; Jon Sicilia; Fermín Acosta; Sandra Fajardo; Álvaro Chiner‐Oms; Mario Matteo; Norberto Simboli; Iñaki Comas; Patricia Muñoz; Beatriz López; Viviana Ritacco; Darío García de Viedma
Source:
Transboundary and emerging diseases 2022 v.69 no.2 pp. 327-336
ISSN:
1865-1674
Subject:
multiple drug resistance,   etc   ; patients; tuberculosis; Argentina;     Show all 4 Subjects
Abstract:
... Recurrent tuberculosis occurs due to exogenous reinfection or reactivation/persistence. We analysed 90 sequential MDR Mtb isolates obtained in Argentina from 27 patients with previously diagnosed MDR‐TB that recurred in 2018 (1–10 years, 2–10 isolates per patient). Three long‐term predominant strains were responsible for 63% of all MDR‐TB recurrences. Most of the remaining patients were infected b ...
DOI:
10.1111/tbed.13982

4. In Situ Hypoxia-Induced Supramolecular Perylene Diimide Radical Anions in Tumors for Photothermal Therapy with Improved Specificity

Author:
Hua Wang; Ke-Fei Xue; Yuchong Yang; Hao Hu; Jiang-Fei Xu; Xi Zhang
Source:
Journal of the American Chemical Society 2022 v.144 no.5 pp. 2360-2367
ISSN:
1520-5126
Subject:
drug resistance,   etc   ; absorption; hypoxia; metastasis; neoplasms; photothermotherapy;     Show all 6 Subjects
Abstract:
... Considering that hypoxia is closely associated with tumor proliferation, invasion, metastasis, and drug resistance, it is of great significance to overcome hypoxia in tumor treatment. Herein, we report a hypoxia-induced specific photothermal therapy (PTT) based on the photothermal agent of supramolecular perylene diimide radical anions. Hypoxic regions in various tumors display strong reductive ab ...
DOI:
10.1021/jacs.1c13067

5. Strategies employed in the design of antimicrobial peptides with enhanced proteolytic stability

Author:
Zhenheng Lai; Xiaojie Yuan; Hongyu Chen; Yunhui Zhu; Na Dong; Anshan Shan
Source:
Biotechnology advances 2022 v.59 pp. 107962
ISSN:
0734-9750
Subject:
multiple drug resistance,   etc   ; antimicrobial peptides; biotechnology; proteolysis;     Show all 4 Subjects
Abstract:
... Due to the alarming developing rate of multidrug-resistant bacterial pathogens, the development and modification of antimicrobial peptides (AMPs) are unprecedentedly active. Despite the fact that considerable efforts have been expended on the discovery and design strategies of AMPs, the clinical translation of peptide antibiotics remains inadequate. A large number of articles and reviews credited ...
DOI:
10.1016/j.biotechadv.2022.107962

6. Viral resistance burden and APOBEC editing correlate with virological response in heavily treatment-experienced people living with multi-drug resistant HIV

Author:
Daniele Armenia; Maria Mercedes Santoro; Maria Concetta Bellocchi; Luca Carioti; Laura Galli; Andrea Galli; Rossana Scutari; Eleonora Salsi; Cristina Mussini; Gaetana Sterrantino; Leonardo Calza; Barbara Rossetti; Maurizio Zazzi; Antonella Castagna; PRESTIGIO Registry Study Group
Source:
International journal of antimicrobial agents 2022 v.59 no.1 pp. 106492
ISSN:
0924-8579
Subject:
multiple drug resistance,   etc   ; DNA; RNA; people; therapeutics;     Show all 5 Subjects
Abstract:
... The impact of drug resistance mutational load and APOBEC editing in heavily treatment-experienced (HTE) people living with multidrug-resistant HIV has not been investigated.This study explored the HIV-DNA and HIV-RNA mutational load of drug resistance and APOBEC-related mutations through next-generation sequencing (NGS, Illumina MiSeq) in 20 failing HTE participants enrolled in the PRESTIGIO regis ...
DOI:
10.1016/j.ijantimicag.2021.106492

7. Characterization of a Novel Carbapenem-Resistant Klebsiella michiganensis Strain Coharboring the blaSIM-1, blaOXA-1, blaCTX-M-14, qnrS, and aac(6′)-Ib-cr Genes

Author:
Jianfen Xu; Hui Ding; Yunan Zhao; Jiaoli Chen; Zhigang Zhao; Jiansheng Huang; Rongzhen Wu
Source:
Current microbiology 2022 v.79 no.8 pp. 228
ISSN:
0343-8651
Subject:
drug resistance,   etc   ; Klebsiella oxytoca; hospitals; microbiology; plasmids; China;     Show all 6 Subjects
Abstract:
... Carbapenem-resistant Klebsiella michiganensis (CRKM) and Klebsiella oxytoca (CRKO) strains have occasionally been reported to cause severe infections. However, SIM-producing K. michiganensis strains have never been described. In this study, we phenotypically and genetically characterized 6 CRKM and CRKO strains isolated over the past 10 years at a Chinese tertiary hospital. All six strains were po ...
DOI:
10.1007/s00284-022-02920-7

8. Engineered extracellular vesicles and their mimics in cardiovascular diseases

Author:
Jialin Lai; Chaobo Huang; Yuxuan Guo; Lang Rao
Source:
Journal of controlled release 2022 v.347 pp. 27-43
ISSN:
0168-3659
Subject:
drug resistance,   etc   ; bioavailability; death; lipids; therapeutics; traditional medicine;     Show all 6 Subjects
Abstract:
... Cardiovascular diseases (CVDs) are the leading cause of death worldwide. Current pharmacological interventions for the CVDs suffer from low bioavailability, low retention rate, poor targeting, drug resistance complicated side effects. Extracellular vesicles (EVs), which are lipid vesicles secreted by cells, play key roles in pathological processes of CVDs. Engineered EVs and EV mimics with superio ...
DOI:
10.1016/j.jconrel.2022.04.046

9. In vitro assessment of the antibacterial effects of the combinations of fosfomycin, colistin, trimethoprim and nitrofurantoin against multi‐drug–resistant Escherichia coli

Author:
W. Mohamed Abu El‐Wafa; A.M. Abouwarda
Source:
Letters in applied microbiology 2022 v.74 no.3 pp. 334-343
ISSN:
0266-8254
Subject:
multiple drug resistance,   etc   ; colistin; fosfomycin; microbiology; nitrofurantoin; trimethoprim;     Show all 6 Subjects
Abstract:
... MDR UPEC has become a global health challenge. Our study investigates the pairwise interactions among FOS, COL, NIT and TRI against 29 UPEC strains using the checkerboard method. The synergistic combinations are further evaluated for their bactericidal effects against the most resistant strain (MRS) using the time‐kill method. The results showed that 100% of these strains were resistant to TRI and ...
DOI:
10.1111/lam.13619

10. Multidrug-resistant enteric bacteria in Nigeria and potential use of bacteriophages as biocontrol

Author:
Greater Kayode Oyejobi; Waidi Folorunso Sule; Sunday Babatunde Akinde; Fazal Mehmood Khan; Faith Ogolla
Source:
Science of the total environment 2022 v.824 pp. 153842
ISSN:
0048-9697
Subject:
multiple drug resistance,   etc   ; biological control; environment; gastroenteritis; Nigeria;     Show all 5 Subjects
Abstract:
... Enteric bacterial pathogens have been implicated in many cases of gastroenteritis in Nigeria, a West African country. This situation is worsened by some reports of the high prevalence of multidrug-resistant enteric bacteria. To better prepare for situations in which even antibiotics of last resort would fail to treat infections caused by these pathogens, attention should be paid to alternative ant ...
DOI:
10.1016/j.scitotenv.2022.153842

11. Transmission-blocking drugs for malaria elimination

Author:
Lyn-Marié Birkholtz; Pietro Alano; Didier Leroy
Source:
Trends in parasitology 2022 v.38 no.5 pp. 390-403
ISSN:
1471-4922
Subject:
drug resistance,   etc   ; antimalarials; malaria; parasites; parasitology; risk reduction;     Show all 6 Subjects
Abstract:
... Preventing human-to-mosquito transmission of malaria parasites provides possible solutions to interrupt the malaria parasite life cycle for malaria elimination. The development of validated routine assays enabled the discovery of such transmission-blocking compounds. Currently, one development priority remains on combinations of dual-active compounds with equipotent activity against both the disea ...
DOI:
10.1016/j.pt.2022.01.011

12. Pursuit of next-generation glycopeptides: a journey with vancomycin

Author:
Yash Acharya; Geetika Dhanda; Paramita Sarkar; Jayanta Haldar
Source:
Chemical communications 2022 v.58 no.12 pp. 1881-1897
ISSN:
1364-548X
Subject:
multiple drug resistance,   etc   ; biofilm; glycopeptides; pharmacokinetics; sugars; therapeutics; vancomycin;     Show all 7 Subjects
Abstract:
... Vancomycin, a blockbuster antibiotic of the glycopeptide class, has been a life-saving therapeutic against multidrug-resistant Gram-positive infections. The emergence of glycopeptide resistance has however enunciated the need to develop credible alternatives with potent activity against vancomycin-resistant bacteria. Medicinal chemistry has responded to this challenge through various strategies, o ...
DOI:
10.1039/d1cc06635h

13. Regulation of miR-30b in cancer development, apoptosis, and drug resistance

Author:
Zhen-Jie Fu; Yan Chen; Yu-Qin Xu; Mei-Ai Lin; Hang Wen; Yi-Tao Chen; Pei-Lei Pan
Source:
Open life sciences 2022 v.17 no.1 pp. 102-106
ISSN:
2391-5412
Subject:
drug resistance,   etc   ; antineoplastic agents; apoptosis; carcinogenesis; chromosomes; genes; neoplasms;     Show all 7 Subjects
Abstract:
... miR-30b, which is encoded by the gene located on chromosome 8q24.22, plays an important role in a variety of diseases. In most types of tumors, miR-30b significantly inhibits the proliferation, migration, and invasion of cancer cells through the regulation of target genes. Moreover, miR-30b can inhibit the PI3K/AKT signaling pathway through the regulation of EGFR, AKT, Derlin-1, GNA13, SIX1, and o ...
DOI:
10.1515/biol-2022-0017

14. Role of nanomaterials in deactivating multiple drug resistance efflux pumps – A review

Author:
Nibedita Dey; C. Kamatchi; A.S. Vickram; K. Anbarasu; S. Thanigaivel; Jeyanthi Palanivelu; Arivalagan Pugazhendhi; Vinoth Kumar Ponnusamy
Source:
Environmental research 2022 v.204 pp. 111968
ISSN:
0013-9351
Subject:
multiple drug resistance,   etc   ; antibiotics; lifestyle; medicine; pathogens; research; synergism;     Show all 7 Subjects
Abstract:
... The changes in lifestyle and living conditions have affected not only humans but also microorganisms. As man invents new drugs and therapies, pathogens alter themselves to survive and thrive. Multiple drug resistance (MDR) is the talk of the town for decades now. Many generations of medications have been termed useless as MDR rises among the infectious population. The surge in nanotechnology has b ...
DOI:
10.1016/j.envres.2021.111968

15. Biochemical, structural, and functional studies reveal that MAB_4324c from Mycobacterium abscessus is an active tandem repeat N‐acetyltransferase

Author:
Husam M. A. B. Alsarraf; Kien Lam Ung; Matt D. Johansen; Juliette Dimon; Vincent Olieric; Laurent Kremer; Mickaël Blaise
Source:
FEBS letters 2022 v.596 no.12 pp. 1516-1532
ISSN:
0014-5793
Subject:
drug resistance,   etc   ; Mycobacterium abscessus; acetyltransferases; crystal structure; macrophages; polyamines; virulence;     Show all 7 Subjects
Abstract:
... Mycobacterium abscessus is a pathogenic non‐tuberculous mycobacterium that possesses an intrinsic drug resistance profile. Several N‐acetyltransferases mediate drug resistance and/or participate in M. abscessus virulence. Mining the M. abscessus genome has revealed genes encoding additional N‐acetyltransferases whose functions remain uncharacterized, among them MAB_4324c. Here, we showed that the ...
DOI:
10.1002/1873-3468.14360

16. Degradable Bactericide Constructed Using a Charge-Reversal Surfactant against Plant Pathogenic Bacteria

Author:
Lingda Zeng; Jiang-Fei Xu; Xi Zhang
Source:
ACS applied materials & interfaces 2022 v.14 no.8 pp. 10134-10141
ISSN:
1944-8252
Subject:
drug resistance,   etc   ; antibacterial properties; food security; humans; hydrolysis; surfactants; toxicity;     Show all 7 Subjects
Abstract:
... Plant bacterial diseases are serious problems in agriculture, posing threats to global food security and the agricultural economy. Here, a degradable agricultural bactericide AMC-10 constructed using a charge-reversal surfactant, from being positively charged to negatively charged, was designed and synthesized. AMC-10 possessed high bactericidal activity toward plant pathogenic bacteria, consequen ...
DOI:
10.1021/acsami.1c24588

17. ccelerated cycling PCR: A novel tool for rapid, sensitive and specific detection of single-nucleotide mutation within 30 min

Author:
Zhixian Luan; Yan Zhao; Yanling Wang; Cuiping Ma; Chao Shi
Source:
Journal of microbiological methods 2022 pp. 106527
ISSN:
0167-7012
Subject:
drug resistance,   etc   ; DNA; Helicobacter pylori; genotype; genotyping; mutation; rapid methods;     Show all 7 Subjects
Abstract:
... Rapid detection of single-nucleotide mutations (SNMs) has played a vital role for point-of-care testing. We herein first introduced accelerated thermal cycling into conventional allele-specific qPCR (AS-qPCR), named accelerated cycling PCR (AC-PCR) to achieve rapid and sensitive detection of SNM. It could simultaneously detect 10 copies of H. pylori DNA and identify its clarithromycin-resistance g ...
DOI:
10.1016/j.mimet.2022.106527

18. Antibiofilm Activity of β-Lactam/β-Lactamase Inhibitor Combination against Multidrug-Resistant Salmonella Typhimurium

Author:
Nana Nguefang Laure; Juhee Ahn
Source:
Pathogens 2022 v.11 no.3 pp. -
ISSN:
2076-0817
Subject:
multiple drug resistance,   etc   ; Salmonella Typhimurium; ampicillin; antimicrobial properties; biofilm; ceftriaxone; sulbactam;     Show all 7 Subjects
Abstract:
... This study was designed to assess the effect of β-lactam/β-lactamase inhibitor combinations on the inhibition of biofilm formation of Salmonella Typhimurium. The anti-planktonic and anti-biofilm activities of ampicillin (AMP), ceftriaxone (CEF), and combination treatments of antibiotics and sulbactam (AMP + SUL and CEF + SUL) were evaluated against antibiotic-sensitive S. Typhimurium ATCC 19585 (S ...
DOI:
10.3390/pathogens11030349

19. Benefits and challenges of antibody drug conjugates as novel form of chemotherapy

Author:
Syeda Warisul Fatima; Sunil K. Khare
Source:
Journal of controlled release 2022 v.341 pp. 555-565
ISSN:
0168-3659
Subject:
drug resistance,   etc   ; cancer therapy; cytotoxicity; drug therapy; drugs; immunotherapy; moieties; pharmacokinetics;     Show all 8 Subjects
Abstract:
... Antibody drug conjugates (ADCs) are an emerging therapeutic modality for targeted cancer treatment. They represent the unique amalgamation of chemotherapy and immunotherapy. ADCs comprise of monoclonal antibodies linked with drugs (payloads) through a chemical linker designed to deliver the cytotoxic moiety to the cancer cells. The present paper is a review of recent clinical advances of each comp ...
DOI:
10.1016/j.jconrel.2021.12.013

20. CDCP1: A promising diagnostic biomarker and therapeutic target for human cancer

Author:
Xiao Qi; Jing Gao; Zihao Li; Guangxin Zhang; Jialin Li; Yilin Fu; Mingjun Cai; Hongda Wang; Ti Tong
Source:
Life sciences 2022 v.301 pp. 120600
ISSN:
0024-3205
Subject:
drug resistance,   etc   ; biomarkers; carcinogenesis; digestive system; humans; prognosis; therapeutics; transmembrane proteins;     Show all 8 Subjects
Abstract:
... CUB domain-containing protein 1 (CDCP1), as an emerging transmembrane protein, is overexpressed in a variety of malignant tumors including respiratory tumors, digestive system cancers, hematological malignancies and urogenital cancers. Several cancer-related proteins have been reported to interact with CDCP1. It acts as a crucial hub in multiple classical signaling pathways of tumorigenesis and pr ...
DOI:
10.1016/j.lfs.2022.120600