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1. Pharmacogenetics of Drugs Used in the Treatment of Cancers

Author:
Beata Franczyk; Jacek Rysz; Anna Gluba-Brzózka
Source:
Genes 2022 v.13 no.2 pp. -
ISSN:
2073-4425
Subject:
drug therapy,   etc   ; DNA; patients; pharmacogenomics; risk;     Show all 5 Subjects
Abstract:
... Pharmacogenomics is based on the understanding of the individual differences in drug use, the response to drug therapy (efficacy and toxicity), and the mechanisms underlying variable drug responses. The identification of DNA variants which markedly contribute to inter-individual variations in drug responses would improve the efficacy of treatments and decrease the rate of the adverse side effects ...
DOI:
10.3390/genes13020311

2. Synthesis and self-assembly of an acid/reduction co-triggered degradable amphiphilic copolyprodrug as a tumor-selective drug self-delivery system

Author:
Xinming Li; Peng Liu
Source:
Journal of materials chemistry B 2022 v.10 no.15 pp. 2926-2932
ISSN:
2050-7518
Subject:
drug therapy,   etc   ; condensation reactions; drugs; neoplasms; solubility;     Show all 5 Subjects
Abstract:
... Polyprodrugs with drugs as the structural units have been recognized as promising drug self-delivery systems (DSDSs) for tumor chemotherapy, especially ones in which the drug structural units are linked with both pH- and reduction-cleavable conjugations. However, stable DOX derivatives are released after the acid/reduction co-triggered degradation, exhibiting low antitumor efficacy due to their lo ...
DOI:
10.1039/d2tb00150k

3. Buccal Micronucleus Cytome Assay for the Evaluation of Cytogenetic Status of Healthcare Professionals Contacting with Anti-Cancer Drugs

Author:
K. I. Kirsanov; L. P. Sycheva; E. A. Lesovaya; E. M. Zhidkova; O. A. Vlasova; A. V. Osipova; E. S. Lylova; D. D. Grigorieva; E. M. Kulakova; L. G. Solenova; G. A. Belitsky; I. N. Mikhaylova; M. G. Yakubovskaya
Source:
Russian journal of genetics 2022 v.58 no.5 pp. 528-537
ISSN:
1022-7954
Subject:
drug therapy,   etc   ; apoptosis; exposure duration; health services; mutagens;     Show all 5 Subjects
Abstract:
... Healthcare professionals of chemotherapy departments are in a regular contact with anticancer drugs that have genotoxic properties. The analysis of the cytogenetic status of healthcare professionals (54 individuals) was for the first time carried out using a new promising noninvasive method, buccal micronucleus cytome assay with the calculation of integral indices. The effect was estimated with di ...
DOI:
10.1134/S1022795422050052

4. Doxorubicin induced aggregation of α-synuclein: Insights into the mechanism of drug induced Parkinsonism

Author:
Ankush Garg; Sharmistha Sinha
Source:
Colloids and surfaces 2022 v.212 pp. 112371
ISSN:
0927-7765
Subject:
drug therapy,   etc   ; L-dopa; Parkinson disease; doxorubicin; spectroscopy;     Show all 5 Subjects
Abstract:
... The aggregation of α-synuclein is a prominent feature of Parkinson’s disease. It is induced by factors such as genetic mutations and presence of metal salts leading to Parkinson’s like symptoms. Existing case studies show that patients undergoing cancer chemotherapeutics are also prone to developing Parkinson’s like symptoms. However, the underlying cause behind onset of these symptoms is not unde ...
DOI:
10.1016/j.colsurfb.2022.112371

5. Multicenter, randomized, double‐blinded, placebo‐controlled study of rabacfosadine in dogs with lymphoma

Author:
Kristen M. Weishaar; Zachary M. Wright; Mona P. Rosenberg; Gerald S. Post; Jennifer A. McDaniel; Craig A. Clifford; Brenda S. Phillips; Philip J. Bergman; Elissa K. Randall; Anne C. Avery; Douglas H. Thamm; Abigail A. Christman Hull; Cathy M. Gust; Ann R. Donoghue
Source:
Journal of veterinary internal medicine 2022 v.36 no.1 pp. 215-226
ISSN:
0891-6640
Subject:
drug therapy,   etc   ; appetite; diarrhea; lymphoma; placebos; veterinary medicine;     Show all 6 Subjects
Abstract:
... BACKGROUND: Rabacfosadine (RAB, Tanovea‐CA1) is a novel chemotherapy agent conditionally approved for the treatment of lymphoma in dogs. HYPOTHESIS/OBJECTIVES: To determine the efficacy and safety of RAB in dogs with lymphoma. ANIMALS: One hundred and fifty‐eight client‐owned dogs with naïve or relapsed multicentric lymphoma were prospectively enrolled from January to October 2019. METHODS: Dogs w ...
DOI:
10.1111/jvim.16341

6. The Relationship between Malnutrition and Subjective Taste Change Experienced by Patients with Cancer Receiving Outpatient Chemotherapy Treatment

Author:
İlknur Özkan; Seçil Taylan; Nermin Eroğlu; Nurcan Kolaç
Source:
Nutrition and cancer 2022 v.74 no.5 pp. 1670-1679
ISSN:
1532-7914
Subject:
drug therapy,   etc   ; malnutrition; nutrition assessment; patients; risk; taste;     Show all 6 Subjects
Abstract:
... Taste changes and malnutrition are two important problems in patients with different types of cancer. This study was conducted to evaluate the relationship between malnutrition and subjective taste changes experienced by cancer patients receiving outpatient chemotherapy. The study used a cross-sectional design and was carried out with 1382 patients with cancer receiving outpatient chemotherapy. Of ...
DOI:
10.1080/01635581.2021.1957485

7. A sensitive and selective HPLC–MS3 method for therapeutic drug monitoring of meropenem and its validation by comparison with HPLC–MS2 methods

Author:
Haiwei Cao; Lei Yin; Haihuan Cao; Haiyang Guo; Wenbo Ren; Yanyan Li; Jing Huang
Source:
Journal of separation science 2022 v.45 no.10 pp. 1683-1692
ISSN:
1615-9306
Subject:
drug therapy,   etc   ; humans; meropenem; methanol; separation; tandem mass spectrometry;     Show all 6 Subjects
Abstract:
... Meropenem, a representative β‐lactam antibiotic, is widely used to treat complicated and serious infections. Therefore, it is of great significance to monitor the plasma drug concentration for individualized antimicrobial therapy. This study first describes the development and validation of high‐performance liquid chromatography–tandem mass spectrometry cubed method for monitoring meropenem in hum ...
DOI:
10.1002/jssc.202200064

8. Acid-Triggered H₂O₂ Self-Supplying Nanoplatform for ¹⁹F-MRI with Enhanced Chemo–Chemodynamic Therapy

Author:
Ruijuan Zhang; Qian Ma; Gaofei Hu; Leyu Wang
Source:
Analytical chemistry 2022 v.94 no.8 pp. 3727-3734
ISSN:
1520-6882
Subject:
drug therapy,   etc   ; analytical chemistry; drugs; magnetism; neoplasms; paclitaxel; toxicity;     Show all 7 Subjects
Abstract:
... The real-time tracking and efficacy evaluation of therapeutic nanoplatforms especially in deep-tissues is of great importance but faces challenges. Meanwhile, chemodynamic therapy (CDT), relying on Fenton reaction by converting H₂O₂ into toxic hydroxyl radicals (•OH), has drawn wide interests in the fabrication of nanozymes for tumor therapy, while endogenous H₂O₂ is usually insufficient for effec ...
DOI:
10.1021/acs.analchem.2c00023

9. Autoimagem corporal e comportamento alimentar de mulheres após cirurgia bariátrica

Author:
Jeane Lorena Lima Dias; Manuela Maria de Lima Carvalhal; Aline Leão Reis; Daniela Lopes Gomes
Source:
Revista brasileira de obesidade, nutrição e emagrecimento 2022 v.15 no.92 pp. 1-9
ISSN:
1981-9919
Subject:
drug therapy,   etc   ; bariatric surgery; body image; food preparation; relapse;     Show all 5 Subjects
Abstract:
... Individuals undergoing bariatric surgery may present inappropriate behaviors and eating habits, especially in the long term, in addition to the presence of psychological disorders, which are factors that may favor weight relapse. Objective: To describe eating behavior and perception of body self-image in women over 24 months after bariatric surgery. Materials and methods: Eating behavior and perce ...

10. Curing two predominant viruses occurring in Lentinula edodes by chemotherapy and mycelial fragmentation methods

Author:
Yijia Sun; Mengpei Guo; Jinjie Wang; Yinbing Bian; Zhangyi Xu
Source:
Journal of virological methods 2022 v.300 pp. 114370
ISSN:
0166-0934
Subject:
drug therapy,   etc   ; Lentinula edodes; fungi; germplasm; mycelium; mycoviruses; pigmentation;     Show all 7 Subjects
Abstract:
... Previous research has established that Lentinula edodes mycovirus HKB (LeV-HKB) and L. edodes partitivirus 1(LePV1) are major mycoviruses identified in L.edodes germplasm. In this paper, two different methods for curing these two dsRNA mycoviruses, ribavirin treatment and mycelial fragmentation, were evaluated for the first time. Mycelial fragmentation was found to resulted in LeV-HKB- and LePV1-c ...
DOI:
10.1016/j.jviromet.2021.114370

11. Effects of Fasting on Chemotherapy Treatment Response: A Systematic Review of Current Evidence and Suggestions for the Design of Future Clinical Trials

Author:
Esther Heyde Selke Costa; Jenifer Faria Krüger; Carolina Q. Camargo; Vinícius Basso Preti; Elaine Hillesheim; Estela I. Rabito
Source:
Nutrition and cancer 2022 v.74 no.4 pp. 1213-1221
ISSN:
1532-7914
Subject:
drug therapy,   etc   ; adults; fasting; nutrition; risk; systematic review; toxicity;     Show all 7 Subjects
Abstract:
... Fasting associated with chemotherapy could improve the efficacy of anticancer treatments without increasing their adverse effects. We conducted a systematic review following the PRISMA Statement to summarize the evidence on the effects of fasting on treatment response of adults undergoing chemotherapy and make suggestions for the design of future clinical trials The search was performed on CENTRAL ...
DOI:
10.1080/01635581.2021.1938147

12. Lingguizhugan decoction dynamically regulates MAPKs and AKT signaling pathways to retrogress the pathological progression of cardiac hypertrophy to heart failure

Author:
Yao Chen; Lin Li; Cunyu Hu; Xin Zhao; Peng Zhang; Yanxu Chang; Ye Shang; Yafen Pang; Weiqiang Qian; Xianzhe Qiu; Hongxia Zhang; Deqin Zhang; Shukun Zhang; Yuhong Li
Source:
Phytomedicine 2022 v.98 pp. 153951
ISSN:
0944-7113
Subject:
drug therapy,   etc   ; heart failure; hypertrophy; morbidity; mortality; pharmacology; transcriptomics;     Show all 7 Subjects
Abstract:
... Heart failure (HF) is a grave health concern, with high morbidity and mortality, calling for the urgent need for new and alternative pharmacotherapies. Lingguizhugan decoction (LD) is a classic Chinese formula clinically used to treat HF. However, the underlying mechanisms involved are not fully elucidated. Based on that, this study aims to investigate the effects and underlying mechanisms of LD o ...
DOI:
10.1016/j.phymed.2022.153951

13. Recent advancements in techniques for analyzing modern, atypical antidepressants in complex biological matrices and their application in biomedical studies

Author:
Anna Roszkowska; Alina Plenis; Piotr Kowalski; Tomasz Bączek; Ilona Olędzka
Source:
Trends in analytical chemistry 2022 v.152 pp. 116609
ISSN:
0165-9936
Subject:
drug therapy,   etc   ; analytical chemistry; forensic sciences; medicine; microextraction; toxicology;     Show all 6 Subjects
Abstract:
... Significant advances in the pharmacological management of depression have been made since the introduction of the first-generation of antidepressants in the 1950s. Currently, treatment options for depression include pharmacotherapy with newer generations of drugs, such as atypical ADs. However, since ADs belong to a group of psychotropic drugs, some of their constituent compounds can be used illeg ...
DOI:
10.1016/j.trac.2022.116609

14. Role of Glutamine in the Management of Oral Mucositis in Patients with Cancer: A Meta-Analysis of Randomized Controlled Trials

Author:
Gang Tang; Wang Huang; Linyu Zhang; Zhengqiang Wei
Source:
Nutrition and cancer 2022 v.74 no.2 pp. 482-495
ISSN:
1532-7914
Subject:
drug therapy,   etc   ; analgesics; glutamine; meta-analysis; nutrition; radiotherapy; risk;     Show all 7 Subjects
Abstract:
... As the effectiveness of glutamine supplementation for oral mucositis (OM) in patients with cancer remains controversial, a comprehensive summary and analysis of available evidence is necessary. The aim of the present meta-analysis was to evaluate the benefits of glutamine supplementation on OM and OM-related adverse reactions in patients with cancer receiving chemotherapy (CT) and/or radiotherapy ...
DOI:
10.1080/01635581.2021.1889623

15. Targeted nanomedicine in cisplatin-based cancer therapeutics

Author:
Yu Han; Panyue Wen; Junjie Li; Kazunori Kataoka
Source:
Journal of controlled release 2022 v.345 pp. 709-720
ISSN:
0168-3659
Subject:
drug therapy,   etc   ; DNA repair; cisplatin; immunotherapy; nanomedicine; neoplasms; toxicity;     Show all 7 Subjects
Abstract:
... Since its license in 1978, cisplatin has proved to be one of the most successful chemotherapeutic agents in the world. However, two acute challenges facing cisplatin, resistance and toxicity, have resulted in a bottleneck of clinical application. Targeted nanomedicine shows great promise in delivering cisplatin for maximizing efficacy while minimizing off-target toxicity. This article surveyed the ...
DOI:
10.1016/j.jconrel.2022.03.049

16. Buffet-style Cu(II) for enhance disulfiram-based cancer therapy

Author:
Liping Zhao; Xiaoxia Wang; Han Lou; Mingxia Jiang; Xinghan Wu; Jiamin Qin; Jingqi Zhang; Xiuwen Guan; Wentong Li; Weifen Zhang; Jinlong Ma
Source:
Journal of colloid and interface science 2022 v.624 pp. 734-746
ISSN:
0021-9797
Subject:
drug therapy,   etc   ; cancer therapy; disulfiram; folic acid; irradiation; neoplasms; photothermotherapy;     Show all 7 Subjects
Abstract:
... Studies have shown that disulfiram (DSF) can combine with Cu²⁺ to form bis(N, N-diethyldithiocarbamate) copper(II) complex (CuET) as antitumor drugs. However, there is insufficient endogenous Cu²⁺ dose to eradicate cancer cells selectively. Inspired by the buffet, we use Cu²⁺ doped hollow zeolitic imidazolate framework nanoparticles (HZIFCᵤ) as the carrier and equipped with DSF and indocyanine gre ...
DOI:
10.1016/j.jcis.2022.06.009

17. Dietary Supplements in Chemotherapy-Induced Peripheral Neuropathy: A New Hope?

Author:
Katarzyna Szklener; Sebastian Szklener; Adam Michalski; Klaudia Żak; Weronika Kuryło; Konrad Rejdak; Sławomir Mańdziuk
Source:
Nutrients 2022 v.14 no.3 pp. -
ISSN:
2072-6643
Subject:
drug therapy,   etc   ; curcumin; peripheral nervous system diseases; quality of life;     Show all 4 Subjects
Abstract:
... Chemotherapy-induced peripheral neuropathy (CIPN) is one of the main and most prevalent side effects of chemotherapy, significantly affecting the quality of life of patients and the course of chemotherapeutic treatment. Nevertheless, despite its prevalence, the management of the CIPN is considered particularly challenging, with this condition often being perceived as very difficult or even impossi ...
DOI:
10.3390/nu14030625

18. Impact of an outpatient telestroke clinic on management of rural stroke patients

Author:
Carlos Garcia‐Esperon; Beng Lim Alvin Chew; Fiona Minett; Joseph Cheah; Jennifer Rutherford; Bradley Wilsmore; Mark W. Parsons; Christopher R. Levi; Neil J. Spratt
Source:
Australian journal of rural health 2022 v.30 no.3 pp. 337-342
ISSN:
1038-5282
Subject:
drug therapy,   etc   ; clinical trials; hospitals; males; rural health; stroke; Australia;     Show all 7 Subjects
Abstract:
... OBJECTIVE: Report on feasibility, use and effects on investigations and treatment of a neurologist‐supported stroke clinic in rural Australia. DESIGN: Data were collected prospectively for consecutive patients referred to atelehealth stroke clinic from November 2018 to August 2021. SETTINGS, PARTICIPANTS AND INTERVENTIONS: Patients attended the local hospital, with a rural stroke care coordinator, ...
DOI:
10.1111/ajr.12849

19. Nanomaterials in cancer: Reviewing the combination of hyperthermia and triggered chemotherapy

Author:
Tiago P. Ribeiro; J. Agostinho Moreira; Fernando J. Monteiro; Marta S. Laranjeira
Source:
Journal of controlled release 2022 v.347 pp. 89-103
ISSN:
0168-3659
Subject:
drug therapy,   etc   ; cancer therapy; drugs; energy conversion; fever; heat; neoplasms;     Show all 7 Subjects
Abstract:
... Nanoparticle mediated hyperthermia has been explored as a method to increase cancer treatment efficacy by heating tumours inside-out. With that purpose, nanoparticles have been designed and their properties tailored to respond to external stimuli and convert the supplied energy into heat, therefore inducing damage to tumour cells. Moreover, the combination of hyperthermia with chemotherapy has bee ...
DOI:
10.1016/j.jconrel.2022.04.045

20. Non-stereotactic radiotherapy in older cancer patients

Author:
Silvana Parisi; Sara Lillo; Alberto Cacciola; Gianluca Ferini; Vito Valenti; Anna Viola; Anna Santacaterina; Angelo Platania; Anna Brogna; Consuelo Tamburella; Stefano Pergolizzi
Source:
Heliyon 2022 v.8 no.6 pp. e09593
ISSN:
2405-8440
Subject:
drug therapy,   etc   ; fractionation; immunotherapy; irradiation; patient compliance; radiotherapy; surgery; toxicity;     Show all 8 Subjects
Abstract:
... Old or very old oncological patients represent a heterogeneous and frail population due to concomitant comorbidities. Whether radiotherapy alone or in combination with novel cancer drugs may provide a clear benefit in this setting of patients is still a matter of debate. The aim of our review is to analyze the evaluation process and the different therapeutic possibilities in older cancer patients, ...
DOI:
10.1016/j.heliyon.2022.e09593