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1. Zinc, ω-3 polyunsaturated fatty acids and vitamin D: An essential combination for prevention and treatment of cancers

Author:
Story, Michael J.
Source:
Biochimie 2021 v.181 pp. 100-122
ISSN:
0300-9084
Subject:
drug therapy,   etc   ; vitamin D; zinc;     Show all 3 Subjects
Abstract:
... Zinc, ω-3 polyunsaturated fatty acids (PUFAs) and vitamin D are essential nutrients for health, maturation and general wellbeing. Extensive literature searches have revealed the widespread similarity in molecular biological properties of zinc, ω-3 PUFAs and vitamin D, and their similar anti-cancer properties, even though they have different modes of action. These three nutrients are separately ess ...
DOI:
10.1016/j.biochi.2020.11.019

2. Water-Soluble Heliomycin Derivatives to Target i-Motif DNA

Author:
Tikhomirov, Alexander S.; Abdelhamid, Mahmoud A. S.; Nadysev, Georgy Y.; Zatonsky, George V.; Bykov, Eugene E.; Chueh, Pin Ju; Waller, Zoë A. E.; Shchekotikhin, Andrey E.
Source:
Journal of natural products 2021 v.84 no.5 pp. 1617-1625
ISSN:
1520-6025
Subject:
drug therapy,   etc   ; DNA; antibiotics; ligands; water solubility;     Show all 5 Subjects
Abstract:
... Heliomycin (also known as resistomycin) is an antibiotic with a broad spectrum of biological activities. However, low aqueous solubility and poor knowledge of its chemical properties have limited the development of this natural product. Here, we present an original scheme for the introduction of aminoalkylamine residues at positions 3, 5, and 7 of heliomycin and, using this, have prepared a series ...
DOI:
10.1021/acs.jnatprod.1c00162

3. Honey and children: only a grandma’s panacea or a real useful tool?

Author:
Pecoraro, Luca; Flore, Alice Iride; Dalle Carbonare, Luca; Piacentini, Giorgio; Pietrobelli, Angelo
Source:
International journal of food sciences and nutrition 2021 v.72 no.3 pp. 300-307
ISSN:
1465-3478
Subject:
drug therapy,   etc   ; adults; honey; nutrition; pediatrics;     Show all 5 Subjects
Abstract:
... Honey is a natural product that has been used as medication since the ancient times for its nutritive and therapeutic value. Despite these properties, honey use has been limited in evidence-based medicine due to the lack of evidence in clinical settings, particularly in paediatric population. An increasing interest has grown towards honey during the last years. The aim of this article is to examin ...
DOI:
10.1080/09637486.2020.1811958

4. The effects of single-dose administration of two topical antiglaucoma medications, 0.005% latanoprost and 0.125% demecarium bromide, on intraocular pressure and iridocorneal angle parameters in nonglaucomatous companion rabbits

Author:
Li Puma, Margaret C.; Pederson, Samantha L.; Johnston, Matthew S.; Cleymaet, Allison M.; Crawford, Amanda C.; Dinger, Shelby C.; Li Puma, Lance C.; Freeman, Kate S.
Source:
Journal of exotic pet medicine 2021 v.37 pp. 32-38
ISSN:
1557-5063
Subject:
drug therapy,   etc   ; eyes; glaucoma; medicine; tomography; ultrasonics;     Show all 6 Subjects
Abstract:
... Glaucoma is a blinding, painful disease in mammals, including rabbits. This study aimed to determine effects on intraocular pressure (IOP) and iridocorneal angle (ICA) morphology of two antiglaucoma therapies, 0.005% latanoprost (latanoprost) and 0.125% demecarium bromide (demecarium) in companion rabbits. Twenty healthy rabbits of varying breeds and ages were used. All animals received a complete ...
DOI:
10.1053/j.jepm.2020.12.014

5. Knockdown of PC4 increases chemosensitivity of Oxaliplatin in triple negative breast cancer by suppressing mTOR pathway

Author:
Wang, Qing; Ma, Le; Chen, Long; Chen, Hongdan; Luo, Min; Yang, Wei; Liao, Fengying; Gong, Qiang; Wang, Yang; Yang, Zeyu; Wu, Jie; Zhang, Can; Zheng, Jiancheng; Han, Shiqian; Leng, Yu; Luo, Peng; Shi, Chunmeng
Source:
Biochemical and biophysical research communications 2021 v.544 pp. 65-72
ISSN:
0006-291X
Subject:
drug therapy,   etc   ; breast neoplasms; carcinogenesis; humans; research;     Show all 5 Subjects
Abstract:
... As a multifunctional nuclear protein, the human positive cofactor 4 (PC4) is highly expressed in various tumors including breast cancer and has potential roles in cancer development and progression. However, the functional signatures and molecular mechanisms of PC4 in triple negative breast cancer (TNBC) progression and chemotherapeutic response are still unknown. In this study, we found that PC4 ...
DOI:
10.1016/j.bbrc.2021.01.029

6. Gene silencing delivery systems for the treatment of pancreatic cancer: Where and what to target next?

Author:
Vetvicka, David; Sivak, Ladislav; Jogdeo, Chinmay M.; Kumar, Raj; Khan, Rubayat; Hang, Yu; Oupický, David
Source:
Journal of controlled release 2021 v.331 pp. 246-259
ISSN:
0168-3659
Subject:
drug therapy,   etc   ; death; genes; pancreatic neoplasms; patients;     Show all 5 Subjects
Abstract:
... Despite intensive research efforts and development of numerous new anticancer drugs and treatment strategies over the past decades, there has been only very limited improvement in overall patient survival and in effective treatment options for pancreatic cancer. Current chemotherapy improves survival in terms of months and death rates in pancreatic cancer patients are almost equivalent to incidenc ...
DOI:
10.1016/j.jconrel.2021.01.020

7. Chemotherapy‐induced diarrhoea in dogs and its management with smectite: Results of a monocentric open‐label randomized clinical trial

Author:
Fournier, Quentin; Serra, Juan‐Carlos; Williams, Claire; Bavcar, Spela
Source:
Veterinary and comparative oncology 2021 v.19 no.1 pp. 25-33
ISSN:
1476-5810
Subject:
drug therapy,   etc   ; clay; diarrhea; metronidazole; smectite;     Show all 5 Subjects
Abstract:
... Chemotherapy‐induced diarrhoea (CID) is a frequent chemotherapy adverse event in dogs. Yet, there is currently no consensus regarding its management. Smectite is a natural medical clay, widely used in the treatment of acute diarrhoea in humans. The objectives of this study were to assess the efficacy of smectite in the management of CID in dogs, and to collect epidemiological data on CID. For each ...
DOI:
10.1111/vco.12631

8. The Effects of Anti-obesity Pharmacotherapy Interventions on Psychosocial Factors Among Adolescents with Obesity: a Scoping Review

Author:
Dillard, Jackson R.; Newsome, Faith A.; Kelly, Aaron S.; Gross, Amy C.; Morgan-Daniel, Jane; Adkins, Lauren E.; Madem, Sweta S.; Cardel, Michelle I.
Source:
Current nutrition reports 2021 v.10 no.1 pp. 58-70
ISSN:
2161-3311
Subject:
drug therapy,   etc   ; adolescents; lifestyle; obesity; weight loss;     Show all 5 Subjects
Abstract:
... PURPOSE OF REVIEW: The purpose of this review was to investigate and synthesize psychosocial outcomes from pharmacotherapy experimental trials for weight loss among adolescents with obesity. RECENT FINDINGS: There is a paucity of research regarding pharmacological interventions for adolescents with obesity. These studies have typically reported reductions in weight, and side effects have been inco ...
DOI:
10.1007/s13668-021-00351-7

9. Current State and Promising Opportunities on Pharmaceutical Approaches in the Treatment of Polymicrobial Diseases

Author:
Sartini, Sartini; Permana, Andi Dian; Mitra, Saikat; Tareq, Abu Montakim; Salim, Emil; Ahmad, Islamudin; Harapan, Harapan; Emran, Talha Bin; Nainu, Firzan
Source:
Pathogens 2021 v.10 no.2
ISSN:
2076-0817
Subject:
drug therapy,   etc   ; biofilm; multiple drug resistance;     Show all 3 Subjects
Abstract:
... In recent years, the emergence of newly identified acute and chronic infectious disorders caused by diverse combinations of pathogens, termed polymicrobial diseases, has had catastrophic consequences for humans. Antimicrobial agents have been clinically proven to be effective in the pharmacological treatment of polymicrobial diseases. Unfortunately, an increasing trend in the emergence of multi-dr ...
DOI:
10.3390/pathogens10020245

10. MichiGAN: sampling from disentangled representations of single-cell data using generative adversarial networks

Author:
Yu, Hengshi; Welch, Joshua D.
Source:
Genome biology 2021 v.22 no.1 pp. 158
ISSN:
1474-760X
Subject:
drug therapy,   etc   ; data collection; gene expression; genome; sequence analysis; Michigan;     Show all 6 Subjects
Abstract:
... Deep generative models such as variational autoencoders (VAEs) and generative adversarial networks (GANs) generate and manipulate high-dimensional images. We systematically assess the complementary strengths and weaknesses of these models on single-cell gene expression data. We also develop MichiGAN, a novel neural network that combines the strengths of VAEs and GANs to sample from disentangled re ...
DOI:
10.1186/s13059-021-02373-4

11. Understanding the impact of age-related changes in the gut microbiome on chronic diseases and the prospect of elderly-specific dietary interventions

Author:
Pellanda, Paola; Ghosh, Tarini Shankar; O’Toole, Paul W
Source:
Current opinion in biotechnology 2021 v.70 pp. 48-55
ISSN:
0958-1669
Subject:
drug therapy,   etc   ; biotechnology; diet; intestinal microorganisms; lifestyle; microbiome; sarcopenia;     Show all 7 Subjects
Abstract:
... Ageing is associated with characteristic changes including a gradual decline of physiological functions, inflamm-aging, sarcopenia, and the associated onset of multiple diseases. Another factor potentially contributing to enhanced susceptibility to multiple diseases is aging-associated alteration in the gut microbiome. These alterations include a loss of commensals and gain of disease-associated p ...
DOI:
10.1016/j.copbio.2020.11.001

12. Small interfering RNA (siRNA) to target genes and molecular pathways in glioblastoma therapy: Current status with an emphasis on delivery systems

Author:
Mirzaei, Sepideh; Mahabady, Mahmood Khaksary; Zabolian, Amirhossein; Abbaspour, Alireza; Fallahzadeh, Peyman; Noori, Maedeh; Hashemi, Farid; Hushmandi, Kiavash; Daneshi, Salman; Kumar, Alan Prem; Aref, Amir Reza; Samarghandian, Saeed; Makvandi, Pooyan; Khan, Haroon; Hamblin, Michael R.; Ashrafizadeh, Milad; Zarrabi, Ali
Source:
Life sciences 2021 v.275 pp. 119368
ISSN:
0024-3205
Subject:
drug therapy,   etc   ; aggression; brain; disease progression; glioblastoma; immunotherapy; radiotherapy; surgery;     Show all 8 Subjects
Abstract:
... Glioblastoma multiforme (GBM) is one of the worst brain tumors arising from glial cells, causing many deaths annually. Surgery, chemotherapy, radiotherapy and immunotherapy are used for GBM treatment. However, GBM is still an incurable disease, and new approaches are required for its successful treatment. Because mutations and amplifications occurring in several genes are responsible for the progr ...
DOI:
10.1016/j.lfs.2021.119368

13. Nanobodies as efficient drug-carriers: Progress and trends in chemotherapy

Author:
Panikar, Sandeep Surendra; Banu, Nehla; Haramati, Jesse; del Toro-Arreola, Susana; Riera Leal, Annie; Salas, Pedro
Source:
Journal of controlled release 2021 v.334 pp. 389-412
ISSN:
0168-3659
Subject:
drug therapy,   etc   ; antibodies; antigens; bacteriophages; drugs; nanocarriers; solubility; yeasts;     Show all 8 Subjects
Abstract:
... Nanobodies (Nb) have a promising future as a part of next generation chemodrug delivery systems. Nb, or VHH, are small (15 kDa) monomeric antibody fragments consisting of the antigen binding region of heavy chain antibodies. Heavy chain antibodies are naturally produced by camelids, however the structure of their VHH regions can be readily reproduced in industrial expression systems, such as bacte ...
DOI:
10.1016/j.jconrel.2021.05.004

14. Green synthesis and properties of arginine derived complexes for assorted drug delivery systems: A review

Author:
Patel, Dinal V.; Patel, Mehul N.; Dholakia, Mansi S.; Suhagia, B.N.
Source:
Sustainable chemistry and pharmacy 2021 v.21 pp. 100441
ISSN:
2352-5541
Subject:
drug therapy,   etc   ; active ingredients; arginine; drugs; green chemistry; researchers; toxicity;     Show all 7 Subjects
Abstract:
... In the current scenario, green technologies in chemistry and various fields create attention to every researcher. The green synthesis provides environmentally and eco-friendly raw materials and intermediate products, making a simple process without using harmful and toxic reactants. Amino acids are one of the reactants from which the intermediates or excipients can be made using the straightforwar ...
DOI:
10.1016/j.scp.2021.100441

15. Peripheral blood cell ratios as prognostic factors in canine diffuse large B‐cell lymphoma treated with CHOP protocol

Author:
Henriques, Joaquim; Felisberto, Ricardo; Constantino‐Casas, Fernando; Cabeçadas, José; Dobson, Jane
Source:
Veterinary and comparative oncology 2021 v.19 no.2 pp. 242-252
ISSN:
1476-5810
Subject:
drug therapy,   etc   ; B-cell lymphoma; anemia; blood; dogs; humans; models;     Show all 7 Subjects
Abstract:
... Diffuse large B‐cell lymphoma (DLBCL) is the most common haematopoietic tumour in dogs and recognized as clinical model for its human counterpart. Recently, neutrophil‐to‐lymphocyte (NLR) and lymphocyte‐to‐monocyte (LMR) ratios have been shown to predict time‐to‐progression (TTP) and lymphoma‐specific survival (LSS) in dogs with DLBCL treated with CHOP‐based chemotherapy. We retrospectively evalua ...
DOI:
10.1111/vco.12668

16. Anti-inflammatory and cytotoxic agents from Xylaria sp. SWUF09-62 fungus

Author:
Patjana, Theerawat; Jantaharn, Phongphan; Katrun, Praewpan; Mongkolthanaruk, Wiyada; Suwannasai, Nuttika; Senawong, Thanaset; Tontapha, Sarawut; Amornkitbumrung, Vittaya; McCloskey, Sirirath
Source:
Natural product research 2021 v.35 no.12 pp. 2010-2019
ISSN:
1478-6427
Subject:
drug therapy,   etc   ; Xylaria; cytotoxicity; fungi; nitric oxide; research;     Show all 6 Subjects
Abstract:
... The ongoing search for anti-cancer agents from microorganisms led to the isolation of four new compounds including 6-ethyl-8-hydroxy-4H-chromen-4-one (1), 6-ethyl-7,8-dihydroxy-4H-chromen-4-one (2), (3S)-3,4-dihydro-8-hydroxy-7-methoxy-3-methylisocoumarin (3) and (3S)-3,4-dihydro-5,7,8-trihydroxy-3-methylisocoumarin (4), together with eleven known compounds (5–15) from Xylaria sp. SWUF09-62 fungus ...
DOI:
10.1080/14786419.2019.1652292

17. Pediatric and Adolescent Oncofertility in Male Patients—From Alpha to Omega

Author:
Bîcă, Ovidiu; Sârbu, Ioan; Ciongradi, Carmen Iulia
Source:
Genes 2021 v.12 no.5
ISSN:
2073-4425
Subject:
drug therapy,   etc   ; adolescents; adults; childhood; conception; genes; guidelines; males;     Show all 8 Subjects
Abstract:
... This article reviews the latest information about preserving reproductive potential that can offer enhanced prospects for future conception in the pediatric male population with cancer, whose fertility is threatened because of the gonadotoxic effects of chemotherapy and radiation. An estimated 400,000 children and adolescents aged 0–19 years will be diagnosed with cancer each year. Fertility is co ...
DOI:
10.3390/genes12050701

18. Applications of Catechins in the Treatment of Bacterial Infections

Author:
Wu, Meishan; Brown, Angela C.
Source:
Pathogens 2021 v.10 no.5
ISSN:
2076-0817
Subject:
drug therapy,   etc   ; absorption; beverages; bioavailability; catechin; drugs; nanobiotechnology; tea;     Show all 8 Subjects
Abstract:
... Tea is the second most commonly consumed beverage worldwide. Along with its aromatic and delicate flavors that make it an enjoyable beverage, studies report numerous health advantages in tea consumption, including applications in antimicrobial therapy. The antimicrobial properties of tea are related to catechin and its derivatives, which are natural flavonoids that are abundant in tea. Increasing ...
DOI:
10.3390/pathogens10050546

19. Waste-minimising measures to achieve sustainable supply and use of medication

Author:
Smale, Elisabeth M.; Egberts, Toine C.G.; Heerdink, Eibert R.; van den Bemt, Bart J.F.; Bekker, Charlotte L.
Source:
Sustainable chemistry and pharmacy 2021 v.20 pp. 100400
ISSN:
2352-5541
Subject:
drug therapy,   etc   ; green chemistry; health services; shelf life; stakeholders; wastes;     Show all 6 Subjects
Abstract:
... Medication waste has a high impact on the healthcare budget and detrimental effects on the environment. Therefore, preventing medication from remaining unused through the pharmaceutical chain forms an interesting approach to achieve sustainable supply and use of medication. This scoping review focusses on how stakeholders involved can prevent the waste of potentially viable medication.Manufacturer ...
DOI:
10.1016/j.scp.2021.100400

20. Sensitivity to Immune Checkpoint Blockade in Advanced Non-Small Cell Lung Cancer Patients with EGFR Exon 20 Insertion Mutations

Author:
Metro, Giulio; Baglivo, Sara; Bellezza, Guido; Mandarano, Martina; Gili, Alessio; Marchetti, Giovanni; Toraldo, Marco; Molica, Carmen; Reda, Maria Sole; Tofanetti, Francesca Romana; Siggillino, Annamaria; Prosperi, Enrico; Giglietti, Antonella; Di Girolamo, Bruna; Garaffa, Miriam; Marasciulo, Francesca; Minotti, Vincenzo; Gunnellini, Marco; Guida, Annalisa; Sassi, Monica; Sidoni, Angelo; Roila, Fausto; Ludovini, Vienna
Source:
Genes 2021 v.12 no.5
ISSN:
2073-4425
Subject:
drug therapy,   etc   ; exons; immunotherapy; lung neoplasms; multivariate analysis; mutation;     Show all 6 Subjects
Abstract:
... Besides platinum-based chemotherapy, no established treatment option exists for advanced non-small-cell lung cancer (NSCLC) patients with EGFR exon 20 (Ex20ins) insertion mutations. We sought to determine the clinical outcome of patients with this EGFR mutation subtype in the immunotherapy era. Thirty NSCLCs with EGFR Ex20ins mutations were identified, of whom 15 had received immune checkpoint blo ...
DOI:
10.3390/genes12050679