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1. Drug databases and their contributions to drug repurposing

Author:
Masoudi-Sobhanzadeh, Yosef; Omidi, Yadollah; Amanlou, Massoud; Masoudi-Nejad, Ali
Source:
Genomics 2020 v.112 no.2 pp. 1087-1095
ISSN:
0888-7543
Subject:
drug development; drugs,   etc   ; Internet; databases;     Show all 4 Subjects
Abstract:
... Drug repurposing is an interesting field in the drug discovery scope because of reducing time and cost. It is also considered as an appropriate method for finding medications for orphan and rare diseases. Hence, many researchers have proposed novel methods based on databases which contain different information. Thus, a suitable organization of data which facilitates the repurposing applications an ...
DOI:
10.1016/j.ygeno.2019.06.021

2. Hutchinson-Gilford progeria syndrome: Rejuvenating old drugs to fight accelerated ageing

Author:
Guilbert, Solenn M.; Cardoso, Déborah; Lévy, Nicolas; Muchir, Antoine; Nissan, Xavier
Source:
Methods 2020
ISSN:
1046-2023
Subject:
drugs,   etc   ; genetic disorders; therapeutics;     Show all 3 Subjects
Abstract:
... What if the next generation of successful treatments was hidden in the current pharmacopoeia? Identifying new indications for existing drugs, also called the drug repurposing or drug rediscovery process, is a highly efficient and low-cost strategy. First reported almost a century ago, drug repurposing has emerged as a valuable therapeutic option for diseases that do not have specific treatments an ...
DOI:
10.1016/j.ymeth.2020.04.005

3. Design and analysis of bridging studies with prior probabilities on the null and alternative hypotheses

Author:
Zeng, Donglin; Pan, Zhiying; Lin, D. Y.
Source:
Biometrics 2020 v.76 no.1 pp. 224-234
ISSN:
0006-341X
Subject:
drugs,   etc   ; biometry; pharmaceutical industry;     Show all 3 Subjects
Abstract:
... The pharmaceutical industry and regulatory agencies are increasingly interested in conducting bridging studies in order to bring an approved drug product from the original region (eg, United States or European Union) to a new region (eg, Asian‐Pacific countries). In this article, we provide a new methodology for the design and analysis of bridging studies by assuming prior knowledge on how the nul ...
DOI:
10.1111/biom.13175

4. Correction to: Synthesis, characterization and ampyrone drug release behavior of magnetite nanoparticle/2,3-dialdehyde cellulose-6-phosphate composite

Author:
Keshk, Sherif M. A. S.; El-Zahhar, Adel A.; Alsulami, Qana A.; Al-Sehemi, Abdullah G.; Jaremko, Mariusz; Bondock, Samir; Heinze, Thomas
Source:
Cellulose 2020 v.27 no.3 pp. 1619
ISSN:
0969-0239
Subject:
drugs,   etc   ; cellulose; magnetite; nanoparticles;     Show all 4 Subjects
Abstract:
... In the original publication of the article, one of the co-authors name was mistakenly missed out. It has been updated in this correction. ...
DOI:
10.1007/s10570-019-02911-1

5. In vitro effects of lonidamine and 6-aminonicotinamide against Echinococcus granulosussensu stricto and Echinococcus multilocularis

Author:
Xin, Qi; Yuan, Miaomiao; Li, Huanping; Song, Xiaoxia; Lu, Jun; Jing, Tao
Source:
Veterinary research 2020 v.51 no.1 pp. 29
ISSN:
1297-9716
Subject:
drug therapy; drugs,   etc   ; Echinococcus multilocularis; echinococcosis; larvae; zoonoses;     Show all 6 Subjects
Abstract:
... Echinococcosis is a zoonotic disease caused by cestode species of the genus Echinococcus, which demonstrates considerable medical and veterinary concerns. The development of novel drugs for echinococcosis treatment is urgently needed. In this study, we demonstrated that lonidamine (LND) and 6-aminonicotinamide (6-AN) exhibited considerable in vitro effects against both larval- and adult-stage of E ...
DOI:
10.1186/s13567-020-00744-6
PubMed:
32101153
PubMed Central:
PMC7045558

6. Intravesical Hydrogels as Drug Reservoirs

Author:
Qiu, Heping; Guo, Hui; Li, Di; Hou, Yuchuan; Kuang, Tairong; Ding, Jianxun
Source:
Trends in biotechnology 2020 v.38 no.6 pp. 579-583
ISSN:
0167-7799
Subject:
drug delivery systems; drugs,   etc   ; bladder; bladder diseases; hydrogels;     Show all 5 Subjects
Abstract:
... The complex environment in the bladder weakens the efficacy of intravesical therapy. Hydrogel-based drug delivery systems are poised to revolutionize the delivery of therapeutic agents to bladder lesion sites. This forum article highlights the prospective applications of hydrogels as drug reservoirs in treating chronic bladder diseases. ...
DOI:
10.1016/j.tibtech.2019.12.012

7. Mechanism of a long-term controlled drug release system based on simple blended electrospun fibers

Author:
Wu, Jiaen; Zhang, Zixin; Gu, Jin’ge; Zhou, Weixian; Liang, Xiaoyu; Zhou, Guoqiang; Han, Charles C.; Xu, Shanshan; Liu, Ying
Source:
Journal of controlled release 2020 v.320 pp. 337-346
ISSN:
0168-3659
Subject:
drug delivery systems; drug development,   etc   ; antibiotics; ciprofloxacin; polymers;     Show all 5 Subjects
Abstract:
... Drug delivery systems based on electrospun fibers have been under development for many years. However, studies of controllable long-term drug release from electrospun membrane systems and the underlying release mechanisms have seldom been reported.In this study, electrospun membrane drug delivery systems consisting of the antibiotic ciprofloxacin hydrochloride and FDA-approved polymers are fabrica ...
DOI:
10.1016/j.jconrel.2020.01.020

8. An oroxylin A-loaded aggregation-induced emission active polymeric system greatly increased the antitumor efficacy against squamous cell carcinoma

Author:
Zhu, Yejin; Guo, Yongjian; Liu, Mengdi; Wei, Libin; Wang, Xiaotang
Source:
Journal of materials chemistry B 2020 v.8 no.10 pp. 2040-2047
ISSN:
2050-7518
Subject:
drug delivery systems; drugs,   etc   ; flavonoids; pharmacodynamics; polymers; squamous cell carcinoma;     Show all 6 Subjects
Abstract:
... Squamous cell carcinoma (SCC) is a usually responds poorly to treatment suffers from poor therapeutic benefits while oroxylin A (OA) is a promising flavonoid with high anticancer efficacy against various cancer types. Here in our study, in order to reveal the potential of OA based drug delivery systems (DDSs) in the treatment of SCC, we firstly revealed that OA had a certain pharmacodynamic effect ...
DOI:
10.1039/c9tb01818b

9. Identification of drug resistance associated ncRNAs based on comprehensive heterogeneous network

Author:
Huang, Yu-e; Zhou, Shunheng; Liu, Haizhou; Zhou, Xu; Yuan, Mengqin; Hou, Fei; Wang, Lihong; Jiang, Wei
Source:
Life sciences 2020 v.243 pp. 117256
ISSN:
0024-3205
Subject:
drug resistance; drug therapy,   etc   ; antineoplastic agents; microRNA; neoplasm cells; neoplasms;     Show all 6 Subjects
Abstract:
... Chemotherapy and molecularly targeted therapy are main strategies for treatment of cancers. However, long-term treatment makes cancer cells acquire resistance to anti-cancer drugs, which severely limits the effects of cancer treatment. NcRNAs, especially miRNAs and lncRNAs, have been reported to play key roles in drug resistance and could restore drug responses in resistant cells.We presented a ne ...
DOI:
10.1016/j.lfs.2020.117256

10. Natural polysaccharides for controlled delivery of oral therapeutics: a recent update

Author:
Layek, Buddhadev; Mandal, Sanchita
Source:
Carbohydrate polymers 2020 v.230 pp. 115617
ISSN:
0144-8617
Subject:
drug formulations; drugs,   etc   ; biocompatibility; biodegradability; polysaccharides; renewable resources; therapeutics;     Show all 7 Subjects
Abstract:
... Oral controlled release formulations have been at the center of pharmaceutical research over several decades due to their distinct advantages compared to conventional dosage forms where the entire drug payload is released and absorbed rapidly following administration. Natural polysaccharides are extensively being studied as release modifiers in oral controlled release dosage forms because of their ...
DOI:
10.1016/j.carbpol.2019.115617

11. The Journey to Discovering a Flatworm Target of Praziquantel: A Long TRP

Author:
Park, Sang-Kyu; Marchant, Jonathan S.
Source:
Trends in parasitology 2020 v.36 no.2 pp. 182-194
ISSN:
1471-4922
Subject:
drug therapy; drugs,   etc   ; Schistosoma; blood flukes; ion channels; praziquantel; schistosomiasis;     Show all 7 Subjects
Abstract:
... Infections caused by parasitic flatworms impose a considerable worldwide health burden. One of the most impactful is schistosomiasis, a disease caused by parasitic blood flukes. Treatment of schistosomiasis has relied on a single drug – praziquantel (PZQ) – for decades. The utility of PZQ as an essential medication is, however, intertwined with a stark gap in our knowledge as to how this drug work ...
DOI:
10.1016/j.pt.2019.11.002
PubMed:
31787521
PubMed Central:
PMC6937385

12. Analytical and preparative separation of phosphorothioated oligonucleotides: columns and ion-pair reagents

Author:
Enmark, Martin; Bagge, Joakim; Samuelsson, Jörgen; Thunberg, Linda; Örnskov, Eivor; Leek, Hanna; Limé, Fredrik; Fornstedt, Torgny
Source:
Analytical and bioanalytical chemistry 2020 v.412 no.2 pp. 299-309
ISSN:
1618-2642
Subject:
drug development; drugs,   etc   ; diastereomers; oligonucleotides; pharmaceutical industry; triethylamine;     Show all 6 Subjects
Abstract:
... Oligonucleotide drugs represent an emerging area in the pharmaceutical industry. Solid-phase synthesis generates many structurally closely related impurities, making efficient separation systems for purification and analysis a key challenge during pharmaceutical drug development. To increase the fundamental understanding of the important preparative separation step, mass-overloaded injections of a ...
DOI:
10.1007/s00216-019-02236-9
PubMed:
31814048
PubMed Central:
PMC6992550

13. Clinical outcomes of teicoplanin use in the OPAT setting

Author:
Dabrowski, Hannah; Wickham, Helena; De, Surjo; Underwood, Jonathan; Morris-Jones, Stephen; Logan, Sarah; Marks, Michael; Pollara, Gabriele
Source:
International journal of antimicrobial agents 2020 v.55 no.3 pp. 105888
ISSN:
0924-8579
Subject:
drug therapy,   etc   ; Enterococcus; ceftriaxone; patients;     Show all 4 Subjects
Abstract:
... Teicoplanin possesses several convenient properties for use in the delivery of outpatient parenteral antimicrobial therapy (OPAT) services. However, its use is not widespread and data on its efficacy in the OPAT setting are limited. Here we present a case series of patients undergoing OPAT care being treated by either teicoplanin-based (n = 107) or ceftriaxone-based (n = 191) antibiotic regimens. ...
DOI:
10.1016/j.ijantimicag.2020.105888
PubMed:
31923571
PubMed Central:
PMC7068648

14. Ball milling: an efficient and green approach for asymmetric organic syntheses

Author:
Egorov, Ilya N.; Santra, Sougata; Kopchuk, Dmitry S.; Kovalev, Igor S.; Zyryanov, Grigory V.; Majee, Adinath; Ranu, Brindaban C.; Rusinov, Vladimir L.; Chupakhin, Oleg N.
Source:
Green chemistry 2020 v.22 no.2 pp. 302-315
ISSN:
1463-9270
Subject:
drugs,   etc   ; green chemistry; mechanochemistry; milling;     Show all 4 Subjects
Abstract:
... Mechanochemical approaches in an organic synthesis have received increased interest because of their wide applications in green methodologies. Ball milling has been fruitfully utilized in the synthesis of various (elemental) organic scaffolds, including common drugs or drug candidates. However, the utilization of ball milling in asymmetric organic synthesis has not been adequately investigated. Th ...
DOI:
10.1039/c9gc03414e

15. Surface engineering of nanoparticles with ligands for targeted delivery to osteosarcoma

Author:
Huang, Xin; Wu, Wei; Yang, Wenbo; Qing, Xiangcheng; Shao, Zengwu
Source:
Colloids and surfaces 2020 v.190 pp. 110891
ISSN:
0927-7765
Subject:
drug delivery systems; drug therapy; multiple drug resistance,   etc   ; adolescents; adverse effects; ligands; nanomedicine; nanoparticles; osteosarcoma; permeability;     Show all 10 Subjects
Abstract:
... Osteosarcoma is one of the most common malignant bone tumors which affect adolescents. Neoadjuvant chemotherapy followed by operation has become recommended for osteosarcoma treatment. Whereas, the effects of conventional chemotherapy are unsatisfactory because of multidrug resistance, fast clearance rate, nontargeted delivery, side effects and so on. Accordingly, Nanoparticle-mediated targeted dr ...
DOI:
10.1016/j.colsurfb.2020.110891

16. Fabrication of a novel drug-resin combination device for controlled release of dextromethorphan hydrobromide

Author:
Liu, Haofan; Hu, Liandong; Singh, Rahul Pratap; Dave, Brijesh; Chen, Jiawei; Yu, Jiaojiao
Source:
Colloids and surfaces 2020 v.189 pp. 110833
ISSN:
0927-7765
Subject:
drug delivery systems; drug formulations; drugs,   etc   ; experimental design; pharmacokinetics; rabbits; sodium chloride;     Show all 7 Subjects
Abstract:
... The implimentation of newer technologies in drug delivery system have always been the focus of pharmaceutical scientists with advancement of technologies. In this investigation, a novel controlled-release drug-resin combination device (DRC) was designed using dental resin to control the release of dextromethorphan hydrobromide (DH). The influence of different factors on in-vitro drug release were ...
DOI:
10.1016/j.colsurfb.2020.110833

17. A novel whole blood based method for lymphocyte transformation test in drug allergies

Author:
Ayaz, Furkan; Arikoglu, Tugba; Demirhan, Ali; Kuyucu, Semanur
Source:
Journal of immunological methods 2020 v.479 pp. 112745
ISSN:
0022-1759
Subject:
drug hypersensitivity; drug therapy; drugs,   etc   ; antibiotics; ficoll; in vitro studies; lymphocyte proliferation; mononuclear leukocytes; patients; thymidine;     Show all 10 Subjects
Abstract:
... Drug allergies pose a great deal of danger for the patients. It hinders effective treatment procedures in hospitalized patients. Moreover, it complicates the symptoms due to the allergic reactions of the immune system. Allergic reactions may arise against any medication including antibiotics and chemotherapeutics. Therefore, it is crucial to assess the sensitization pattern of the patients to culp ...
DOI:
10.1016/j.jim.2020.112745

18. Itraconazole vs. posaconazole for antifungal prophylaxis in patients with acute myeloid leukemia undergoing intensive chemotherapy: A retrospective study

Author:
Copley, Melissa S.; Waldron, Madeline; Athans, Vasilios; Welch, Sarah C.; Brizendine, Kyle D.; Cober, Eric; Siebenaller, Caitlin
Source:
International journal of antimicrobial agents 2020 v.55 no.3 pp. 105886
ISSN:
0924-8579
Subject:
drug interactions; drug therapy; drugs,   etc   ; diagnostic techniques; disease control; fungi; itraconazole; myeloid leukemia; patients; retrospective studies;     Show all 10 Subjects
Abstract:
... The objective of this study was to compare itraconazole with posaconazole for antifungal prophylaxis in acute myeloid leukemia (AML) patients undergoing intensive chemotherapy.Adult patients with AML received either itraconazole or posaconazole for antifungal prophylaxis while undergoing intensive chemotherapy. The primary endpoint was incidence of prophylaxis failure (change in antifungal agent d ...
DOI:
10.1016/j.ijantimicag.2020.105886

19. Scientific and Regulatory Approach to Botanical Drug Development: A U.S. FDA Perspective

Author:
Wu, Charles; Lee, Su-Lin; Taylor, Cassandra; Li, Jing; Chan, Yen-Ming; Agarwal, Rajiv; Temple, Robert; Throckmorton, Douglas; Tyner, Katherine
Source:
Journal of natural products 2020 v.83 no.2 pp. 552-562
ISSN:
1520-6025
Subject:
Food and Drug Administration; drug development; drugs,   etc   ; herbs; industry; raw materials; therapeutics; United States;     Show all 8 Subjects
Abstract:
... The United States FDA has received over 800 botanical investigational new drug applications (IND) and pre-IND meeting requests (PIND) in the years preceding 2018. The current data show that indications for submitted INDs cover nearly every review division of the FDA. Despite increasing global interest in the investigation of botanical mixtures as drug products, only two botanical new drug applicat ...
DOI:
10.1021/acs.jnatprod.9b00949

20. Focused ultrasound-triggered chemo-gene therapy with multifunctional nanocomplex for enhancing therapeutic efficacy

Author:
Han, Hyounkoo; Kim, Doyeon; Jang, Yongho; Seo, Minkyu; Kim, Kwangmeyung; Lee, Jong Bum; Kim, Hyuncheol
Source:
Journal of controlled release 2020 v.322 pp. 346-356
ISSN:
0168-3659
Subject:
drug delivery systems; drug therapy; drugs,   etc   ; cancer therapy; extracellular matrix; microbubbles; nanomedicine; nanoparticles; neoplasms; permeability; small interfering RNA; ultrasonics;     Show all 12 Subjects
Abstract:
... Nanotechnology-based combination therapies, especially chemo-gene therapy, have been spotlighted as promising alternatives for cancer therapy. However, only a small amount of systemically administered nanomedicines reach the tumor site by the enhanced permeability and retention (EPR) effect, resulting in the limited therapeutic efficacy. Furthermore, the design of ideal drug delivery system for ch ...
DOI:
10.1016/j.jconrel.2020.03.041