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1. Rational pharmacotherapy, de-prescribing and green pharmacy

Author:
Bijl, Dick
Source:
Sustainable chemistry and pharmacy 2019 v.12 pp. 100127
ISSN:
2352-5541
Subject:
drug therapy; drugs,   etc   ; adverse effects; people; Netherlands;     Show all 5 Subjects
Abstract:
... In the Netherlands more than 11 million people use drugs for the most part intended for chronic use. The scientific basis for the enormous amounts of people that use so many drugs in the Netherlands is quite small. Of many drugs the efficacy is hardly proven and only a minority of people improve by using them. Furthermore, the natural course of many complaints and diseases is positive and needs no ...
DOI:
10.1016/j.scp.2019.01.004

2. An LDI-MSI approach for targeted and untargeted differentiation and assessment of pharmaceutical formulations

Author:
Falco, Luís Fernando Godoy; Melo, Carlos Fernando Odir Rodrigues; de Oliveira, Diogo Noin; Guerreiro, Tatiane Melina; Catharino, Rodrigo Ramos
Source:
Talanta 2019 v.197 pp. 92-97
ISSN:
0039-9140
Subject:
drug formulations; drugs,   etc   ; byproducts; desorption; ionization; screening;     Show all 6 Subjects
Abstract:
... Falsified, counterfeit and adulterated medicines are an endemic problem worldwide that results in both monetary and health-related losses. Developing fast and reliable methods that are able to present a timely result based on the drug's spectral profile is an effort that is sure to benefit those involved in the whole distribution chain. We propose herein a Laser Desorption/Ionization imaging-based ...
DOI:
10.1016/j.talanta.2018.12.044

3. Correction to: Current scenario and future strategies to fight artemisinin resistance

Author:
Pasupureddy, Rahul; Atul,; Seshadri, Sriram; Pande, Veena; Dixit, Rajnikant; Pandey, Kailash C.
Source:
Parasitology research 2019 v.118 no.1 pp. 385
ISSN:
0932-0113
Subject:
drug resistance; drug therapy,   etc   ; artemisinin; malaria;     Show all 4 Subjects
Abstract:
... Author Atul Yadav would like to present his name as Atul only to be the same with his previous publications. The original article has been corrected. ...
DOI:
10.1007/s00436-018-6175-1

4. Drug–Target Association Kinetics in Drug Discovery

Author:
IJzerman, Adriaan P.; Guo, Dong
Source:
Trends in biochemical sciences 2019
ISSN:
0968-0004
Subject:
drug design; drugs,   etc   ; dissociation; ligands; pharmacodynamics;     Show all 5 Subjects
Abstract:
... The important role of ligand–receptor binding kinetics in drug design and discovery is increasingly recognized by the drug research community. Over the past decade, accumulating evidence has shown that optimizing the ligand’s dissociation rate constant can lead to desirable duration of in vivo target occupancy and, hence, improved pharmacodynamic properties. However, the association rate constant ...
DOI:
10.1016/j.tibs.2019.04.004

5. Limitation of flow effect on passive sampling accuracy using POCIS with the PRC approach or o-DGT: A pilot-scale evaluation for pharmaceutical compounds

Author:
Buzier, Rémy; Guibal, Robin; Lissalde, Sophie; Guibaud, Gilles
Source:
Chemosphere 2019 v.222 pp. 628-636
ISSN:
0045-6535
Subject:
drugs,   etc   ; models; samplers; uncertainty;     Show all 4 Subjects
Abstract:
... Flow velocity is known to alter passive sampling accuracy. We investigated the POCIS (Polar Organic Chemical Integrative Sampler) with PRC (Performance Reference Compounds) approach and Diffusive Gradients in Thin Films samplers (o-DGT) to limit the effect of flow on the quantification accuracy of ten model pharmaceuticals compounds (0.16 ≤ log KOW ≤ 4.51). POCIS and o-DGT samplers were exposed fo ...
DOI:
10.1016/j.chemosphere.2019.01.181

6. Correction: The efficiency of cytosolic drug delivery using pH-responsive endosomolytic polymers does not correlate with activation of the NLRP3 inflammasome

Author:
Baljon, Jessalyn J.; Dandy, Aamina; Wang-Bishop, Lihong; Wehbe, Mohamed; Jacobson, Max E.; Wilson, John T.
Source:
Biomaterials science 2019 v.7 no.5 pp. 2200
ISSN:
2047-4849
Subject:
drugs,   etc   ; inflammasomes; polymers;     Show all 3 Subjects
Abstract:
... Correction for ‘The efficiency of cytosolic drug delivery using pH-responsive endosomolytic polymers does not correlate with activation of the NLRP3 inflammasome’ by Jessalyn J. Baljon et al., Biomater. Sci., 2019, DOI: 10.1039/c8bm01643g. ...
DOI:
10.1039/c9bm90022e

7. Toxic effects of magnetic nanoparticles on normal cells and organs

Author:
Jiang, Ziyu; Shan, Kuizhong; Song, Jie; Liu, Jingbing; Rajendran, Suresh; Pugazhendhi, Arivalagan; Jacob, Joe Antony; Chen, Baoan
Source:
Life sciences 2019 v.220 pp. 156-161
ISSN:
0024-3205
Subject:
drugs,   etc   ; magnetism; nanoparticles; toxicity;     Show all 4 Subjects
Abstract:
... Magnetic nanoparticles (MNPs) are promising candidates for drug delivery and treatment of various disorders. Toxicity evaluation is a critical point in the development of nanoformulations and therefore, draws considerable attention. Formulations involving individual or combinatorial nanoparticle suspensions might be used for targeted delivery and treatment. This might be a evaluated further for sa ...
DOI:
10.1016/j.lfs.2019.01.056

8. Click and release: bioorthogonal approaches to “on-demand” activation of prodrugs

Author:
Ji, Xingyue; Pan, Zhixiang; Yu, Bingchen; De La Cruz, Ladie Kimberly; Zheng, Yueqin; Ke, Bowen; Wang, Binghe
Source:
Chemical Society reviews 2019 v.48 no.4 pp. 1077-1094
ISSN:
1460-4744
Subject:
drugs,   etc   ; derivatization; moieties;     Show all 3 Subjects
Abstract:
... Prodrug approaches represent an excellent solution to certain pharmaceutical issues commonly encountered in the drug discovery and development process. Along this line, the chemistry needed for the bio-reversible derivatization of drug functional groups for on-demand release is critical. In recent years, “click and release” approaches have shown great promise in the design of prodrugs because of t ...
DOI:
10.1039/c8cs00395e

9. Recent breakthroughs in the stability testing of pharmaceutical compounds

Author:
Jamrógiewicz, Marzena; Pieńkowska, Krystyna
Source:
Trends in analytical chemistry 2019 v.111 pp. 118-127
ISSN:
0165-9936
Subject:
drugs,   etc   ; active ingredients; markets;     Show all 3 Subjects
Abstract:
... Pharmaceutical development is mostly focused on the research leading to approval of a new and viable active substance. However, there is a number of old generation compounds that are still being used in contemporary medicinal practice. So that new analytical developments should cover not only the safety of newly developed drug substances, which is obvious, but should also be directed into the sear ...
DOI:
10.1016/j.trac.2018.12.007

10. The paroxysmal depolarization shift in epilepsy research

Author:
Hotka, Matej; Kubista, Helmut
Source:
The international journal of biochemistry & cell biology 2019 v.107 pp. 77-81
ISSN:
1357-2725
Subject:
drug therapy,   etc   ; epilepsy; research;     Show all 3 Subjects
Abstract:
... Several shortcomings with currently available pharmacotherapy of epilepsy necessitate the search for new drug targets. Paroxysmal depolarization shifts (PDS) represent the cellular correlates of electrographic (e.g. interictal) spikes. While the ionic basis of PDS is understood in great detail, controversy exists regarding their proposed implication in epilepsy. To address this issue and to consid ...
DOI:
10.1016/j.biocel.2018.12.006

11. Current state of the polymeric delivery systems of fluoroquinolones – A review

Author:
Mulas, Karolina; Stefanowicz, Zdzisława; Oledzka, Ewa; Sobczak, Marcin
Source:
Journal of controlled release 2019 v.294 pp. 195-215
ISSN:
0168-3659
Subject:
drug carriers; drug therapy; drug toxicity,   etc   ; antibiotics; chemical bonding; drugs; fluoroquinolones; polymers;     Show all 8 Subjects
Abstract:
... Recently, growing interest in polymers (natural and synthetic) as drug carriers in controlled release formulations and drug targeting systems that may improve the efficacy of treatment and reduce the side effects of a drug therapy, has been observed. Special attention has been paid to improving the effectiveness of antibiotics, which constitute a very important, often life-saving group of drugs. I ...
DOI:
10.1016/j.jconrel.2018.12.021

12. A platform direct compression formulation for low dose sustained-release tablets enabled by a dual particle engineering approach

Author:
Sun, Wei-Jhe; Chen, Hongbo; Aburub, Aktham; Sun, Changquan Calvin
Source:
Powder technology 2019 v.342 pp. 856-863
ISSN:
0032-5910
Subject:
drugs,   etc   ; copper nanoparticles; powders;     Show all 3 Subjects
Abstract:
... Content uniformity (CU) is a well-recognized challenge for low-dose direct compression (DC) tablet formulations. Using a dual particle engineering approach that involves a) forming a segregation-resistant drug-carrier composite to improve CU and b) nanocoating HPMC to enhance flowability, we have developed a platform DC formulation for preparing low-dose drug sustained-release (SR) tablets with ex ...
DOI:
10.1016/j.powtec.2018.10.054

13. Interlaboratory comparison about feasibility of insoluble particulate matter test for injections with reduced test volume in light obscuration method

Author:
Harazono, Akira; Shibata, Hiroko; Kiyoshi, Masato; Muto, Takashi; Fukuda, Jun; Torisu, Tetsuo; Saitoh, Satoshi; Nishimura, Hirotaka; Uchiyama, Susumu; Ishii-Watabe, Akiko
Source:
Biologicals 2019 v.57 pp. 46-49
ISSN:
1045-1056
Subject:
drugs,   etc   ; monitoring; particulates; polystyrenes;     Show all 4 Subjects
Abstract:
... Insoluble particulate matter test for injections in pharmacopoeia is mandatory for parenteral drug products. In this test using light obscuration, four measurements of at least 5-mL are required. Since therapeutic protein injections of low dosage volumes are getting more popular, reduction of test volumes is desired. In this collaborative study, the impact of lower measurement volume on the accura ...
DOI:
10.1016/j.biologicals.2018.12.003

14. Exploring the trans-membrane dynamic mechanisms of single polyamidoamine nano-drugs via a “force tracing” technique

Author:
Zhou, Siyuan; Yang, Boyu; Chen, Yang; Zhang, Qingrong; Cai, Mingjun; Xu, Haijiao; Yang, Guocheng; Wang, Hongda; Shan, Yuping
Source:
RSC advances 2018 v.8 no.16 pp. 8626-8630
ISSN:
2046-2069
Subject:
drug therapy; drugs,   etc   ; nanomaterials;     Show all 3 Subject
Abstract:
... Considerable technological success has been achieved in the drug delivery of nano-drugs for chemotherapy, but the main obstacles in understanding the drug delivery dynamic mechanisms for nano-drug applications stem from technical limitations. In this paper, we explored the trans-membrane dynamic processes of polyamidoamine nano-drugs via a “force tracing” technique. ...
DOI:
10.1039/c8ra00134k

15. Drugs/lamellae interface influences the inner structure of double-loaded liposomes for inhaled anti-TB therapy: An in-depth small-angle neutron scattering investigation

Author:
Truzzi, Eleonora; Meneghetti, Fiorella; Mori, Matteo; Costantino, Luca; Iannuccelli, Valentina; Maretti, Eleonora; Domenici, Fabio; Castellano, Carlo; Rogers, Sarah; Capocefalo, Angela; Leo, Eliana
Source:
Journal of colloid and interface science 2019 v.541 pp. 399-406
ISSN:
0021-9797
Subject:
drug carriers; drugs,   etc   ; breathing; encapsulation; isoniazid; neutron diffraction; rifampicin;     Show all 7 Subjects
Abstract:
... With the aim of developing new drug carriers for inhalation therapy, we report here an in depth investigation of the structure of multilamellar liposomes loaded with two well-established anti-tubercular (anti-TB) drugs, isoniazid (INH) and rifampicin (RIF), by means of small-angle neutron-scattering (SANS) analysis. Unloaded, single drug-loaded and co-loaded liposomes were prepared using different ...
DOI:
10.1016/j.jcis.2019.01.094

16. Light-triggered release of photocaged therapeutics - Where are we now?

Author:
Silva, Joana M.; Silva, Eduardo; Reis, Rui L.
Source:
Journal of controlled release 2019 v.298 pp. 154-176
ISSN:
0168-3659
Subject:
drug delivery systems; drugs,   etc   ; bioavailability; engineering; moieties; patients;     Show all 6 Subjects
Abstract:
... The current available therapeutics face several challenges such as the development of ideal drug delivery systems towards the goal of personalized treatments for patients benefit. The application of light as an exogenous activation mechanism has shown promising outcomes, owning to the spatiotemporal confinement of the treatment in the vicinity of the diseased tissue, which offers many intriguing p ...
DOI:
10.1016/j.jconrel.2019.02.006

17. Clarifying the Link between Toxin–Antitoxin Modules and Bacterial Persistence

Author:
Ronneau, Séverin; Helaine, Sophie
Source:
Journal of molecular biology 2019
ISSN:
0022-2836
Subject:
drugs; multiple drug resistance,   etc   ; antibiotics; bacteria; bacterial infections; phenotype; toxins;     Show all 7 Subjects
Abstract:
... While most of a bacterial population is killed upon antibiotic exposure, a fraction transiently exhibits a multidrug-tolerant phenotype termed antibiotic persistence. This phenomenon enables the bacteria to escape killing by drugs and is presumed to be, at least partly, responsible for the recalcitrance of many bacterial infections. For this reason, understanding mechanisms allowing a fraction of ...
DOI:
10.1016/j.jmb.2019.03.019

18. Potentiation of a neuronal nicotinic receptor via pseudo-agonist site

Author:
Mazzaferro, Simone; Bermudez, Isabel; Sine, Steven M.
Source:
Cellular and molecular life sciences 2019 v.76 no.6 pp. 1151-1167
ISSN:
1420-682X
Subject:
drug design; drugs,   etc   ; agonists; monitoring; mutation; neurons; nicotinic receptors;     Show all 7 Subjects
Abstract:
... Neuronal nicotinic receptors containing α4 and β2 subunits assemble in two pentameric stoichiometries, (α4)₃(β2)₂ and (α4)₂(β2)₃, each with distinct pharmacological signatures; (α4)₃(β2)₂ receptors are strongly potentiated by the drug NS9283, whereas (α4)₂(β2)₃ receptors are unaffected. Despite this stoichiometry-selective pharmacology, the molecular identity of the target for NS9283 remains elusi ...
DOI:
10.1007/s00018-018-2993-7

19. Silk fibroin coaxial bead-on-string fiber materials and their drug release behaviors in different pH

Author:
Xi, Huanjie; Zhao, Huijing
Source:
Journal of materials science 2019 v.54 no.5 pp. 4246-4258
ISSN:
0022-2461
Subject:
drug delivery systems; drugs,   etc   ; fibroins; neoplasms; pH; silk;     Show all 6 Subjects
Abstract:
... Inspired by the different pH between normal tissue and tumor tissue, pH-responsive drug release materials need to be designed to achieve drug-controlled release. Electrospinning is a simple and efficient method to fabricate drug loading and releasing materials. However, burst release of electrospun smooth fibers was often observed in drug delivery process, which is very harmful to the human body. ...
DOI:
10.1007/s10853-018-3137-z

20. Repeated administration of methylphenidate produces reinforcement and downregulates 5-HT-1A receptor expression in the nucleus accumbens

Author:
Salman, Tabinda; Nawaz, Shazia; Waraich, Rizwana S.; Haleem, Darakhshan J.
Source:
Life sciences 2019 v.218 pp. 139-146
ISSN:
0024-3205
Subject:
drug abuse; drugs,   etc   ; cognition; memory; patients; prefrontal cortex; rats; serotonin;     Show all 8 Subjects
Abstract:
... Methylphenidate (MPD) widely prescribed for the treatment of attention deficit hyperactivity disorder (ADHD), is a psychostimulant and can produce addiction in patients treated with it. In view of growing increase in the use of drug by general population as a cognitive enhancer, the present study is designed to investigate reinforcing and cognition enhancing effects of MPD in rats. Associated chan ...
DOI:
10.1016/j.lfs.2018.12.046