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1. In situ fixation and subsequent collection of cultured endothelial cells in a shear flow

Author:
Aldrich, Jessica L.; Long, David S.
Source:
MethodsX 2019 v.6 pp. 1164-1173
ISSN:
2215-0161
Subject:
endothelial cells,   etc   ; chromatin; dissociation;     Show all 3 Subjects
Abstract:
... In situ fixation of adherent cells is a necessary process for downstream assays. Current methods to dissociate adherent endothelial cells require the use of a cell scraper that may introduce variability in nuclear morphology. Also, a cell scraper is not an option for experiments using sealed flow chambers. HMEC-1 cells were sheared at 5 dyn/cm2 for 24 h and then fixed in situ, quenched, and dissoc ...
DOI:
10.1016/j.mex.2019.05.001

2. Correction to: Crosstalk between cancer cells and endothelial cells: implications for tumor progression and intervention

Author:
Choi, Hyojeong; Moon, Aree
Source:
Archives of pharmacal research 2018 v.41 no.9 pp. 941
ISSN:
0253-6269
Subject:
endothelial cells,   etc   ; neoplasm cells; neoplasms;     Show all 3 Subjects
Abstract:
... Unfortunately, there is an error in the original version of the article. The original published article contains an incomplete ‘Acknowledgements’ section. Please find the full ‘Acknowledgements’ section below. ...
DOI:
10.1007/s12272-018-1071-x

3. Isl1-expressing non-venous cell lineage contributes to cardiac lymphatic vessel development

Author:
Maruyama, Kazuaki; Miyagawa-Tomita, Sachiko; Mizukami, Kaoru; Matsuzaki, Fumio; Kurihara, Hiroki
Source:
Developmental biology 2019 v.452 no.2 pp. 134-143
ISSN:
0012-1606
Subject:
endothelial cells,   etc   ; heart; heart diseases; lymph; mesoderm; mice; pharynx;     Show all 7 Subjects
Abstract:
... The origin of the mammalian lymphatic vasculature has been studied for more than a century; however, details regarding organ-specific lymphatic development remain unknown. A recent study reported that cardiac lymphatic endothelial cells (LECs) stem from venous and non-venous origins in mice. Here, we identified Isl1-expressing progenitors as a potential non-venous origin of cardiac LECs. Genetic l ...
DOI:
10.1016/j.ydbio.2019.05.002

4. High density gold nanostructure composites for precise electrochemical detection of human embryonic stem cells in cell mixture

Author:
Suhito, Intan Rosalina; Kang, Ee-Seul; Kim, Da-Seul; Baek, Seungho; Park, Soon-Jung; Moon, Sung-Hwan; Luo, Zhengtang; Lee, Donghyun; Min, Junhong; Kim, Tae-Hyung
Source:
Colloids and surfaces 2019 v.180 pp. 384-392
ISSN:
0927-7765
Subject:
endothelial cells,   etc   ; biocompatibility; electrochemistry; embryonic stem cells; gold; humans; nanogold;     Show all 7 Subjects
Abstract:
... Precise detection of undifferentiated human pluripotent stem cells (hPSCs) and their entire subsequent elimination are incredibly important in preventing teratoma formations after transplantation. Recently, electrochemical sensing platforms have demonstrated immense potential as a new tool to detect remaining hPSCs in label-free and non-destructive manner. Nevertheless, one of the critical huddles ...
DOI:
10.1016/j.colsurfb.2019.04.059

5. Bioengineering human vascular networks: trends and directions in endothelial and perivascular cell sources

Author:
Wang, Kai; Lin, Ruei-Zeng; Melero-Martin, Juan M.
Source:
Cellular and molecular life sciences 2019 v.76 no.3 pp. 421-439
ISSN:
1420-682X
Subject:
endothelial cells,   etc   ; databases; humans; medicine; tissue engineering; wastes;     Show all 6 Subjects
Abstract:
... Tissue engineering holds great promise in regenerative medicine. However, the field of tissue engineering faces a myriad of difficulties. A major challenge is the necessity to integrate vascular networks into bioengineered constructs to enable physiological functions including adequate oxygenation, nutrient delivery, and removal of waste products. The last two decades have seen remarkable progress ...
DOI:
10.1007/s00018-018-2939-0

6. Correction: Sustained delivery of anti-VEGF from injectable hydrogel systems provides a prolonged decrease of endothelial cell proliferation and angiogenesis in vitro

Author:
Fletcher, Nathan A.; Krebs, Melissa D.
Source:
RSC advances 2018 v.8 no.29 pp. 16043
ISSN:
2046-2069
Subject:
endothelial cells,   etc   ; angiogenesis; cell proliferation; hydrogels;     Show all 4 Subjects
Abstract:
... Correction for ‘Sustained delivery of anti-VEGF from injectable hydrogel systems provides a prolonged decrease of endothelial cell proliferation and angiogenesis in vitro’ by Nathan A. Fletcher et al., RSC Adv., 2018, 8, 8999–9005. ...
DOI:
10.1039/c8ra90033g

7. Nanoplasmonics-enhanced label-free imaging of endothelial cell monolayer integrity

Author:
Banville, Frederic A.; Moreau, Julien; Chabot, Kevin; Cattoni, Andrea; Fröhlich, Ulrike; Bryche, Jean-François; Collin, Stéphane; Charette, Paul G.; Grandbois, Michel; Canva, Michael
Source:
Biosensors & bioelectronics 2019 v.141 pp. 111478
ISSN:
0956-5663
Subject:
endothelial cells,   etc   ; biosensors; gold; image analysis; monitoring; nanogold; pharmacology; surface plasmon resonance; thrombin;     Show all 9 Subjects
Abstract:
... Surface plasmon resonance imaging (SPRI) is a powerful label-free imaging modality for the analysis of morphological dynamics in cell monolayers. However, classical plasmonic imaging systems have relatively poor spatial resolution along one axis due to the plasmon mode attenuation distance (tens of μm, typically), which significantly limits their ability to resolve subcellular structures. We addre ...
DOI:
10.1016/j.bios.2019.111478

8. Accelerated endothelialization and suppressed thrombus formation of acellular vascular grafts by modifying with neointima-inducing peptide: A time-dependent analysis of graft patency in rat-abdominal transplantation model

Author:
Mahara, Atsushi; Sakuma, Takahiro; Mihashi, Naoto; Moritan, Toshiyuki; Yamaoka, Tetsuji
Source:
Colloids and surfaces 2019 v.181 pp. 806-813
ISSN:
0927-7765
Subject:
endothelial cells,   etc   ; aorta; in vitro studies; integrins; ligands; miniature swine; models; peptides; rats; thrombosis;     Show all 10 Subjects
Abstract:
... Acellular blood vessels have clinical potential as tissue-engineered vascular grafts. However, neointima is hard to form on their luminal surface. We recently reported the integrin α4β1 ligand peptide (Arg-Glu-Asp-Val) conjugated with a repetitive Pro-Hyp-Gly sequence as luminal surface modifier. By using this peptide, excellent patency of tissue-engineered small-caliber long-bypass grafts in mini ...
DOI:
10.1016/j.colsurfb.2019.06.037

9. Application of a layered model for determination of the elasticity of biological systems

Author:
Rusaczonek, M.; Zapotoczny, B.; Szymonski, M.; Konior, J.
Source:
Micron 2019 v.124 pp. 102705
ISSN:
0968-4328
Subject:
endothelial cells,   etc   ; atomic force microscopy; disease models; fatty liver; liver; mice; physical properties; theoretical models;     Show all 8 Subjects
Abstract:
... Elasticity of biological systems is considered to be an important property that might be related to functional or pathological changes. Therefore, careful study and detailed understanding of cell and tissue elasticity is crucial for correct description of their functioning. Atomic Force Microscopy (AFM) is a powerful technique, which allows for determination of the physical properties, such as ela ...
DOI:
10.1016/j.micron.2019.102705

10. Model systems for studying the blood-brain barrier: Applications and challenges

Author:
Jackson, Sadhana; Meeks, Caitlin; Vézina, Amélie; Robey, Robert W.; Tanner, Kandice; Gottesman, Michael M.
Source:
Biomaterials 2019 v.214 pp. 119217
ISSN:
0142-9612
Subject:
endothelial cells,   etc   ; animal models; blood-brain barrier; central nervous system; drugs; permeability; transporters;     Show all 7 Subjects
Abstract:
... The blood-brain barrier (BBB) poses a serious impediment to the delivery of effective therapies to the central nervous system (CNS). Over time, various model systems have been crafted and used to evaluate the complexities of the BBB, which includes an impermeable physical barrier and a series of energy-dependent efflux pumps. Models of the BBB have mainly sought to assess changes in endothelial ce ...
DOI:
10.1016/j.biomaterials.2019.05.028

11. Autologous endothelialized vein allografts in coronary artery bypass surgery – Long term results

Author:
Herrmann, Florian Ernst Martin; Lamm, Peter; Wellmann, Petra; Milz, Stefan; Hagl, Christian; Juchem, Gerd
Source:
Biomaterials 2019 v.212 pp. 87-97
ISSN:
0142-9612
Subject:
endothelial cells,   etc   ; allografting; angiography; collagen; coronary vessels; cryopreservation; death; immunohistochemistry; monocytes; necropsy; patients;     Show all 11 Subjects
Abstract:
... Lack of autologous graft material restricts the ability to treat patients requiring coronary artery bypass surgery (CABG). An off the shelf tissue engineered small diameter vascular graft is the holy grail of cardiovascular surgery.Allograft saphenous veins were harvested from organ donors, cryopreserved, deendothelialized and then seeded with autologous endothelial cells prior to implantation dur ...
DOI:
10.1016/j.biomaterials.2019.05.019

12. Anti-inflammatory activity of intravenous immunoglobulin through scavenging of heme

Author:
Wiatr, Marie; Merle, Nicolas S.; Boudhabhay, Idris; Poillerat, Victoria; Rossini, Sofia; Lecerf, Maxime; Kaveri, Srini V.; Lacroix-Desmazes, Sébastian; Roumenina, Lubka T.; Dimitrov, Jordan D.
Source:
Molecular immunology 2019 v.111 pp. 205-208
ISSN:
0161-5890
Subject:
endothelial cells,   etc   ; anti-inflammatory activity; complement; heme; humans; immunoglobulins; immunomodulators; intravenous injection; therapeutics;     Show all 9 Subjects
Abstract:
... Therapeutic intravenous immunoglobulin preparations (IVIg) are used for treatment of wide range of autoimmune and inflammatory diseases. Versatile mechanisms have been reported to contribute to the immunomodulatory effects of IVIg. Here we demonstrate that IVIg has a strong potential to inhibit pro-inflammatory effect of extracellular heme. Indeed, the presence of immunoglobulins reduced the poten ...
DOI:
10.1016/j.molimm.2019.04.020

13. Quantitative proteomic study of arsenic treated mouse liver sinusoidal endothelial cells using a reverse super-SILAC method

Author:
Li, Wenbo; Zhang, Jiyang; Lv, Yongzhuang; Sheibani, Nader
Source:
Biochemical and biophysical research communications 2019 v.514 no.2 pp. 475-481
ISSN:
0006-291X
Subject:
endothelial cells,   etc   ; arsenic; blood; drugs; liver; liver function; mice; proteins; proteomics; toxic substances; toxicity;     Show all 11 Subjects
Abstract:
... Liver sinusoidal endothelial cells are the border patrol in the liver. Their open transcellular fenestrations allow the transfer of small and dissolved substances from the blood into the liver parenchymal cells. Fenestrations are dynamic structures, and many drugs and diseases alter their size and number, thus making them an important target for modulation. There is an urgent need to understand ho ...
DOI:
10.1016/j.bbrc.2019.04.172

14. Polydopamine-Based Interfacial Engineering of Extracellular Matrix Hydrogels for the Construction and Long-Term Maintenance of Living Three-Dimensional Tissues

Author:
Park, Sunghee E.; Georgescu, Andrei; Oh, Jeong Min; Kwon, Keon Woo; Huh, Dongeun
Source:
ACS applied materials & interfaces 2019 v.11 no.27 pp. 23919-23925
ISSN:
1944-8252
Subject:
endothelial cells,   etc   ; adhesion; coculture; extracellular matrix; fibroblasts; hydrogels; lungs; models; polymers; quantitative analysis;     Show all 10 Subjects
Abstract:
... Diverse biological processes in the body rely on the ability of cells to exert contractile forces on their extracellular matrix (ECM). In three-dimensional (3D) cell culture, however, this intrinsic cellular property can cause unregulated contraction of ECM hydrogel scaffolds, leading to a loss of surface anchorage and the resultant structural failure of in vitro tissue constructs. Despite advance ...
DOI:
10.1021/acsami.9b07912

15. BRAF, A gatekeeper controlling endothelial permeability

Author:
Declercq, Mathias; Treps, Lucas
Source:
TheFEBS journal 2019 v.286 no.12 pp. 2273-2276
ISSN:
1742-464X
Subject:
endothelial cells,   etc   ; actin; dimerization; mitogen-activated protein kinase; neoplasms; permeability; signal transduction;     Show all 7 Subjects
Abstract:
... The RAF/MEK/ERK signal transduction pathway is commonly deregulated in cancer and is activated by various stimuli regulating a variety of cell responses. In wild‐type endothelial cells, upon permeability stimuli, ROKα, RAF1, BRAF, and RAP1 become activated, inducing a cascade of reactions resulting in F‐actin remodeling and increased cell permeability. Here, Dorard et al. showed that BRAF ablated ...
DOI:
10.1111/febs.14861

16. Characterization of protective antigen CbpB as an adhesin and a plasminogen-binding protein of Erysipelothrix rhusiopathiae

Author:
Zhu, Weifeng; Cai, Chengzhi; Li, Jingtao; Zhang, Qiang; Huang, Jingjing; Jin, Meilin
Source:
Research in veterinary science 2019 v.124 pp. 352-356
ISSN:
0034-5288
Subject:
endothelial cells,   etc   ; Erysipelothrix rhusiopathiae; adhesins; adhesion; antigens; binding proteins; erysipelas; fibronectins; humans; plasminogen; swine; virulence;     Show all 12 Subjects
Abstract:
... Erysipelothrix rhusiopathiae is the causative agent of animal erysipelas and human erysipeloid. E. rhusiopathiae CbpB has been reported to be a protective antigen, but its pathogenic roles are not known. The aim of this study was to evaluate the ability of CbpB to act as an adhesin in E. rhusiopathiae adhesion to porcine endothelial cells as well as a host plasminogen- and fibronectin- binding pro ...
DOI:
10.1016/j.rvsc.2019.04.002

17. Expression pattern of miR-21, miR-25 and PTEN in peripheral blood mononuclear cells of patients with significant or insignificant coronary stenosis

Author:
Nariman-saleh-fam, Ziba; Vahed, Sepideh Zununi; Aghaee-Bakhtiari, Seyed Hamid; Daraei, Abdolreza; Saadatian, Zahra; Kafil, Hossein Samadi; Yousefi, Bahman; Eyvazi, Shirin; Khaheshi, Isa; Parsa, Saeed Alipour; Moravej, Ali; Mousavi, Negar; Bastami, Milad; Mansoori, Yaser
Source:
Gene 2019 v.698 pp. 170-178
ISSN:
0378-1119
Subject:
endothelial cells,   etc   ; atherosclerosis; cell adhesion; coronary artery disease; gene expression; microRNA; mononuclear leukocytes; patients;     Show all 8 Subjects
Abstract:
... Coronary artery disease (CAD) is primarily caused by atherosclerosis, which is a series of chronic inflammatory processes leading to the initiation and progression of vascular endothelial cell injury enhancing plaque formation. As critical components of the immune system, peripheral blood mononuclear cells (PBMCs) actively cross-talk with pathophysiological conditions induced by endothelial cell i ...
DOI:
10.1016/j.gene.2019.02.074

18. H2 relaxin ameliorates angiotensin II-induced endothelial dysfunction through inhibition of excessive mitochondrial fission

Author:
Gao, Lei; Liu, Yue; Wang, Ying; Chen, Wenjia; Yang, Kelaier; Li, Jiawen; Lv, Bo; Zhang, Xin; Chi, Jinyu; Liu, Na; Yin, Xinhua; Zhang, Xiaohui
Source:
Biochemical and biophysical research communications 2019 v.512 no.4 pp. 799-805
ISSN:
0006-291X
Subject:
endothelial cells,   etc   ; angiotensin II; cardiovascular diseases; endothelial nitric oxide synthase; humans; mitochondria; protective effect; relaxin;     Show all 8 Subjects
Abstract:
... The physiological function of endothelial cells plays an important role in maintaining normal cardiovascular function. Endothelial dysfunction induced by AngII (angiotensin II) is the pathological mechanism of occurrence and development of cardiovascular diseases. Human recombinant relaxin-2 (H2 relaxin), which has protective effect on cardiovascular functions, ameliorates damage to endothelial ce ...
DOI:
10.1016/j.bbrc.2019.03.112

19. Talin-2 regulates integrin functions in exosomes

Author:
Soe, Zay Yar; Prajuabjinda, Onmanee; Myint, Phyoe Kyawe; Gaowa, Arong; Kawamoto, Eiji; Park, Eun Jeong; Shimaoka, Motomu
Source:
Biochemical and biophysical research communications 2019 v.512 no.3 pp. 429-434
ISSN:
0006-291X
Subject:
endothelial cells,   etc   ; T-lymphocytes; cell adhesion; exosomes; integrins; intercellular adhesion molecule-1; ligands; talin;     Show all 8 Subjects
Abstract:
... Integrins on exosomes have been shown to mediate binding to recipient cells, potentially playing important roles in controlling exosomal internalization and organ distributions. Although the ability of cellular integrins to mediate cell adhesion is known to be regulated by the cytoplasmic adaptor protein talin, whether the activity of exosomal integrins is similarly regulated by talin remains to b ...
DOI:
10.1016/j.bbrc.2019.03.027

20. Complex roles of necroptosis in cancer

Author:
Zhu, Fang; Zhang, Wei; Yang, Tao; He, Su-dan
Source:
Journal of Zhejiang University 2019 v.20 no.5 pp. 399-413
ISSN:
1673-1581
Subject:
endothelial cells,   etc   ; carcinogenesis; immune response; metastasis; necroptosis; neoplasm cells; neoplasms; phosphotransferases (kinases);     Show all 8 Subjects
Abstract:
... Necroptosis is a tightly regulated form of necrosis that requires the activation of receptor-interacting protein (RIP) kinases RIPK1 and RIPK3, as well as the RIPK3 substrate mixed lineage kinase domain-like protein (MLKL). Because of membrane rupture, necroptotic cells release damage-associated molecular patterns (DAMPs) that evoke immune responses. Necroptosis is emerging as an important cellula ...
DOI:
10.1631/jzus.B1900160