An official website of the United States government
Here’s how you know
Official websites use .gov
A .gov website belongs to an official government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.
endothelialcells, etc ; biocompatible materials; cations; drugs; extracellular matrix; hydrogels; Show all 6 Subjects
Abstract:
... In vitro models are valuable tools for applications including understanding cellular mechanisms and drug screening. Hydrogel biomaterials facilitate in vitro models by mimicking the extracellular matrix and in vivo microenvironment. However, it can be challenging for cells to form tissues in hydrogels that do not degrade. In contrast, if hydrogels degrade too much or too quickly, tissue models may ...
endothelialcells, etc ; dogs; hemangiosarcoma; histopathology; necrosis; nerve tissue; prognosis; Show all 7 Subjects
Abstract:
... The term angiomatosis is used to denote a group of well-known to poorly characterized proliferative vascular entities. In animals, cutaneous progressive angiomatosis (CPA) is a disorder with variable prognosis related to the extension and depth of infiltration of the surrounding tissues by vessels. CPA may share some microscopical features with other vascular proliferations such as low-grade well- ...
endothelialcells, etc ; albumins; chemical communication; free fatty acids; models; zinc; Show all 6 Subjects
Abstract:
... The role of the extracellular medium in influencing metal uptake into cells has not been described quantitatively. In a chemically-defined model system containing albumin, zinc influx into endothelial cells correlates with the extracellular free zinc concentration. Allosteric inhibition of zinc-binding to albumin by free fatty acids increased zinc flux. ...
endothelialcells, etc ; atherosclerosis; diabetes mellitus; glucose; mortality; permeability; unfolded protein response; Show all 7 Subjects
Abstract:
... Diabetes mellitus is hallmarked by accelerated atherosclerosis, a major cause of mortality among patients with diabetes. Efficient therapies for diabetes-associated atherosclerosis are absent. Accelerated atherosclerosis in diabetic patients is associated with reduced endothelial thrombomodulin (TM) expression and impaired activated protein C (aPC) generation. Here, we directly compared the effect ...
endothelialcells, etc ; autophagy; cell viability; energy; homeostasis; hypoxia; ischemia; organelles; phenotype; quality control; Show all 10 Subjects
Abstract:
... Autophagy is an essential intracellular process for cellular quality control. It enables cell homeostasis through the selective degradation of harmful protein aggregates and damaged organelles. Autophagy is essential for recycling nutrients, generating energy to maintain cell viability in most tissues and during adverse conditions such as hypoxia/ischaemia. The progressive understanding of the mec ...
endothelialcells, etc ; animals; blood; brain; dyes; molecular genetics; parenchyma (animal tissue); phenotype; phylogeny; Show all 9 Subjects
Abstract:
... Dynamic brain activity requires timely communications between the brain parenchyma and circulating blood. Brain–blood communication is facilitated by intricate networks of brain vasculature, which display striking heterogeneity in structure and function. This vascular cell heterogeneity in the brain is fundamental to mediating diverse brain functions and has long been recognized. However, the mole ...
Torben Rehn; Pedro Lubiana; Thi Huyen Trang Nguyen; Eva Pansegrau; Marius Schmitt; Lisa Katharina Roth; Jana Brehmer; Thomas Roeder; Dániel Cadar; Nahla Galal Metwally; Iris Bruchhaus
endothelialcells, etc ; Plasmodium falciparum; Plasmodium vivax; erythrocyte membrane; genetically modified organisms; reticulocytes; spleen; Show all 7 Subjects
Abstract:
... Plasmodium falciparum-infected erythrocytes (PfIEs) adhere to endothelial cell receptors (ECRs) of blood vessels mainly via PfEMP1 proteins to escape elimination via the spleen. Evidence suggests that P. vivax-infected reticulocytes (PvIRs) also bind to ECRs, presumably enabled by VIR proteins, as shown by inhibition experiments and studies with transgenic P. falciparum expressing vir genes. To te ...
Matthias Rath; Konrad Schwefel; Matteo Malinverno; Dariush Skowronek; Alexandra Leopoldi; Robin A. Pilz; Doreen Biedenweg; Sander Bekeschus; Josef M. Penninger; Elisabetta Dejana; Ute Felbor
endothelialcells, etc ; RNA; antineoplastic agents; chemokines; coculture; drug development; germ cells; humans; mutants; organoids; Show all 10 Subjects
Abstract:
... Cerebral cavernous malformations (CCM) are low-flow vascular lesions prone to cause severe hemorrhage-associated neurological complications. Pathogenic germline variants in CCM1, CCM2, or CCM3 can be identified in nearly 100% of CCM patients with a positive family history. In line with the concept that tumor-like mechanisms are involved in CCM formation and growth, we here demonstrate an abnormall ...
endothelialcells, etc ; biomechanics; blood-brain barrier; brain damage; drugs; molecular dynamics; therapeutics; tight junctions; Show all 8 Subjects
Abstract:
... Revealing how blast shockwaves open the tight junction of the blood–brain barrier (BBB) is very important for understanding blast-induced traumatic brain injury (bTBI) and shockwave-assisted drug delivery; however, the underlying mechanism remains unresolved. Here, we used multiscale molecular dynamics simulations to reveal the disruption mechanism of claudin-5 protein in a relatively complex BBB ...
endothelialcells, etc ; ascorbic acid; mitochondria; oxidative stress; pathogenesis; patients; pre-eclampsia; therapeutics; vitamin E; Show all 9 Subjects
Abstract:
... Despite considerable research efforts over the past few decades, the pathology of preeclampsia (PE) remains poorly understood with no new FDA-approved treatments. There is a substantial amount of work being conducted by investigators around the world to identify targets to develop therapies for PE. Oxidative stress has been identified as one of the crucial players in pathogenesis of PE and has gar ...
endothelialcells, etc ; angiogenesis; epithelium; macular degeneration; research; secretion; therapeutics; vascular endothelial growth factor A; Show all 8 Subjects
Abstract:
... While it is now well-established that substrate stiffness regulates vascular endothelial growth factor-A (VEGF-A) mediated signaling and functions, causal mechanisms remain poorly understood. Here, we report an underlying role for the PI3K/Akt/mTOR signaling pathway. This pathway is activated on stiffer substrates, is amplified by VEGF-A stimulation, and correlates with enhanced endothelial cell ( ...
endothelialcells, etc ; adhesion; antibiotics; chitosan; crosslinking; drug therapy; fibroblasts; graphene; hydrogels; imines; pH; synergism; xenon; Show all 13 Subjects
Abstract:
... Clinically, systemic antibiotic therapy and traditional dressings care are not satisfactory in treating chronic diabetic ulcers (DU). Therefore, we presented sprayable antibacterial hydrogel for effective treatment of DU by using antibacterial macromolecules (quaternized chitosan, QCS, Mn ≈ 1.5 × 10⁵), photothermal antibacterial nanoparticles (ε-poly-l-lysine grafted graphene quantum dots, GQDs-ε- ...
endothelialcells, etc ; allografting; animal models; caudal vein; inflammation; kidney diseases; kidneys; oxidative stress; research; transfection; Show all 10 Subjects
Abstract:
... Inflammation and glomerular endothelial dysfunction promote diabetic kidney disease (DKD) progression, but the mechanisms are not fully understood. Allograft inflammatory factor-1 (AIF-1) is a protein that regulates inflammatory reactions and immune responses. This study aimed to explore the mechanism of AIF-1 in a DKD animal model and mouse renal glomerular endothelial cells (MRGECs). We injected ...
endothelialcells, etc ; animal models; buds; cell specificity; early development; genes; mammalian embryo; mice; stem cells; Show all 9 Subjects
Abstract:
... Development of the mammalian lymphatic vasculature is a stepwise process requiring the specification of lymphatic endothelial cell progenitors in the embryonic veins, and their subsequent budding to give rise to most of the mature lymphatic vasculature. In mice, formation of the lymphatic vascular network starts inside the cardinal vein at around E9.5 when a subpopulation of venous endothelial cel ...
... The embryonic stage of filarial nematodes, or microfilariae (Mf), shows daily and seasonal periodicity that requires their migration through blood vessels into the lungs, where they are sequestered when not circulating in the peripheral blood. Therefore, Mf and the host endothelium are likely in a permanent state of hide and seek. Interestingly, filarial nematodes co-cultured in media with a murin ...
... Expanded polytetrafluoroethylene (ePTFE) is widely used in clinical applications, such as in the manufacture of blood-contacting implantable devices, owing to its flexibility, biostability, and non-adhesiveness. Modification with peptides is an effective strategy to further improve the ePTFE function. However, the chemical stability of PTFE makes it difficult to modify with peptides. In this study ...
... The response of malignant glioma to immunotherapy remains gloomy due to its discrete immunological environment and poor brain penetration of immunotherapeutic agents. Here, we disclose that ApoE peptide-mediated systemic nanodelivery of granzyme B (GrB) and CpG ODN co-stimulates enhanced immunotherapy of murine malignant LCPN glioma model. ApoE peptide-functionalized polymersomes encapsulating GrB ...
Marie Cadé; Javier Muñoz-Garcia; Antoine Babuty; Louis Paré; Denis Cochonneau; Karim Fekir; Mathias Chatelais; Marie-Françoise Heymann; Anna Lokajczyk; Catherine Boisson-Vidal; Dominique Heymann
... Hemophilia A is an inherited X-linked recessive bleeding disorder caused by deficient activity of blood coagulation factor VIII (FVIII). In addition, hemophilia patients show associated diseases including osteopenia, altered inflammation and vascular fragility which may represent the consequence of recurrent bleeding or may be related to the direct FVIII deficiency. Nowadays, recombinant FVIII is ...
... Skeletal muscle atrophy caused by various conditions including aging, nerve damage, and steroid administration, is a serious health problem worldwide. We recently reported that neuron-derived neurotrophic factor (NDNF) functions as a muscle-derived secreted factor, also known as myokine, which exerts protective actions on endothelial cell and cardiomyocyte function. Here, we investigated whether N ...
endothelialcells, etc ; cell movement; cell proliferation; complement; immunohistochemistry; monocytes; neuroglia; neutrophils; oxidative stress; pregnancy; protein synthesis; research; Show all 12 Subjects
Abstract:
... CD93, also known as complement component C1q receptor, is expressed on the surface of different cellular types such as monocytes, neutrophils, platelets, microglia, and endothelial cells, and it plays a pivotal role in cell proliferation, cell migration, and formation of capillary-like structures. These processes are strictly regulated, and many fetal and maternal players are involved during place ...