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1. Finding the sweet spot: a library of hydrogels with tunable degradation for tissue model development

Author:
Narendra Pandala; Michael A. LaScola; Zachary Hinton; La Shanda T. J. Korley; Erin Lavik
Source:
Journal of materials chemistry B 2022 v.10 no.13 pp. 2194-2203
ISSN:
2050-7518
Subject:
endothelial cells,   etc   ; biocompatible materials; cations; drugs; extracellular matrix; hydrogels;     Show all 6 Subjects
Abstract:
... In vitro models are valuable tools for applications including understanding cellular mechanisms and drug screening. Hydrogel biomaterials facilitate in vitro models by mimicking the extracellular matrix and in vivo microenvironment. However, it can be challenging for cells to form tissues in hydrogels that do not degrade. In contrast, if hydrogels degrade too much or too quickly, tissue models may ...
DOI:
10.1039/d1tb02436a

2. Identification of Histopathological Criteria for the Diagnosis of Canine Cutaneous Progressive Angiomatosis

Author:
Francesca Abramo; Marta Vascellari; Giada Colzi; Luca Pazzini; Francesco Albanese; Lara Olivieri; Claudia Zanardello; Claudia Salvadori; Giancarlo Avallone; Paola Roccabianca
Source:
Veterinary sciences 2022 v.9 no.7 pp. -
ISSN:
2306-7381
Subject:
endothelial cells,   etc   ; dogs; hemangiosarcoma; histopathology; necrosis; nerve tissue; prognosis;     Show all 7 Subjects
Abstract:
... The term angiomatosis is used to denote a group of well-known to poorly characterized proliferative vascular entities. In animals, cutaneous progressive angiomatosis (CPA) is a disorder with variable prognosis related to the extension and depth of infiltration of the surrounding tissues by vessels. CPA may share some microscopical features with other vascular proliferations such as low-grade well- ...
DOI:
10.3390/vetsci9070340

3. Albumin-mediated extracellular zinc speciation drives cellular zinc uptake

Author:
James P. C. Coverdale; Hugo A. van den Berg; Siavash Khazaipoul; Hannah E. Bridgewater; Alan J. Stewart; Claudia A. Blindauer
Source:
Chemical communications 2022 v.58 no.53 pp. 7384-7387
ISSN:
1364-548X
Subject:
endothelial cells,   etc   ; albumins; chemical communication; free fatty acids; models; zinc;     Show all 6 Subjects
Abstract:
... The role of the extracellular medium in influencing metal uptake into cells has not been described quantitatively. In a chemically-defined model system containing albumin, zinc influx into endothelial cells correlates with the extracellular free zinc concentration. Allosteric inhibition of zinc-binding to albumin by free fatty acids increased zinc flux. ...
DOI:
10.1039/d2cc02278h

4. ER-Stress and Senescence Coordinately Promote Endothelial Barrier Dysfunction in Diabetes-Induced Atherosclerosis

Author:
Sameen Fatima; Saira Ambreen; Akash Mathew; Ahmed Elwakiel; Anubhuti Gupta; Kunal Singh; Shruthi Krishnan; Rajiv Rana; Hamzah Khawaja; Dheerendra Gupta; Jayakumar Manoharan; Christian Besler; Ulrich Laufs; Shrey Kohli; Berend Isermann; Khurrum Shahzad
Source:
Nutrients 2022 v.14 no.14 pp. -
ISSN:
2072-6643
Subject:
endothelial cells,   etc   ; atherosclerosis; diabetes mellitus; glucose; mortality; permeability; unfolded protein response;     Show all 7 Subjects
Abstract:
... Diabetes mellitus is hallmarked by accelerated atherosclerosis, a major cause of mortality among patients with diabetes. Efficient therapies for diabetes-associated atherosclerosis are absent. Accelerated atherosclerosis in diabetic patients is associated with reduced endothelial thrombomodulin (TM) expression and impaired activated protein C (aPC) generation. Here, we directly compared the effect ...
DOI:
10.3390/nu14142786

5. Autophagy at the interface of endothelial cell homeostasis and vascular disease

Author:
Eleonora Mameli; Andrea Martello; Andrea Caporali
Source:
FEBS journal 2022 v.289 no.11 pp. 2976-2991
ISSN:
1742-464X
Subject:
endothelial cells,   etc   ; autophagy; cell viability; energy; homeostasis; hypoxia; ischemia; organelles; phenotype; quality control;     Show all 10 Subjects
Abstract:
... Autophagy is an essential intracellular process for cellular quality control. It enables cell homeostasis through the selective degradation of harmful protein aggregates and damaged organelles. Autophagy is essential for recycling nutrients, generating energy to maintain cell viability in most tissues and during adverse conditions such as hypoxia/ischaemia. The progressive understanding of the mec ...
DOI:
10.1111/febs.15873

6. Historical and current perspectives on blood endothelial cell heterogeneity in the brain

Author:
Ryota L. Matsuoka; Luke D. Buck; Keerti P. Vajrala; Rachael E. Quick; Olivia A. Card
Source:
Cellular and molecular life sciences 2022 v.79 no.7 pp. 372
ISSN:
1420-682X
Subject:
endothelial cells,   etc   ; animals; blood; brain; dyes; molecular genetics; parenchyma (animal tissue); phenotype; phylogeny;     Show all 9 Subjects
Abstract:
... Dynamic brain activity requires timely communications between the brain parenchyma and circulating blood. Brain–blood communication is facilitated by intricate networks of brain vasculature, which display striking heterogeneity in structure and function. This vascular cell heterogeneity in the brain is fundamental to mediating diverse brain functions and has long been recognized. However, the mole ...
DOI:
10.1007/s00018-022-04403-1

7. Ectopic Expression of Plasmodium vivax vir Genes in P. falciparum Affects Cytoadhesion via Increased Expression of Specific var Genes

Author:
Torben Rehn; Pedro Lubiana; Thi Huyen Trang Nguyen; Eva Pansegrau; Marius Schmitt; Lisa Katharina Roth; Jana Brehmer; Thomas Roeder; Dániel Cadar; Nahla Galal Metwally; Iris Bruchhaus
Source:
Microorganisms 2022 v.10 no.6 pp. -
ISSN:
2076-2607
Subject:
endothelial cells,   etc   ; Plasmodium falciparum; Plasmodium vivax; erythrocyte membrane; genetically modified organisms; reticulocytes; spleen;     Show all 7 Subjects
Abstract:
... Plasmodium falciparum-infected erythrocytes (PfIEs) adhere to endothelial cell receptors (ECRs) of blood vessels mainly via PfEMP1 proteins to escape elimination via the spleen. Evidence suggests that P. vivax-infected reticulocytes (PvIRs) also bind to ECRs, presumably enabled by VIR proteins, as shown by inhibition experiments and studies with transgenic P. falciparum expressing vir genes. To te ...
DOI:
10.3390/microorganisms10061183

8. Contact-dependent signaling triggers tumor-like proliferation of CCM3 knockout endothelial cells in co-culture with wild-type cells

Author:
Matthias Rath; Konrad Schwefel; Matteo Malinverno; Dariush Skowronek; Alexandra Leopoldi; Robin A. Pilz; Doreen Biedenweg; Sander Bekeschus; Josef M. Penninger; Elisabetta Dejana; Ute Felbor
Source:
Cellular and molecular life sciences 2022 v.79 no.6 pp. 340
ISSN:
1420-682X
Subject:
endothelial cells,   etc   ; RNA; antineoplastic agents; chemokines; coculture; drug development; germ cells; humans; mutants; organoids;     Show all 10 Subjects
Abstract:
... Cerebral cavernous malformations (CCM) are low-flow vascular lesions prone to cause severe hemorrhage-associated neurological complications. Pathogenic germline variants in CCM1, CCM2, or CCM3 can be identified in nearly 100% of CCM patients with a positive family history. In line with the concept that tumor-like mechanisms are involved in CCM formation and growth, we here demonstrate an abnormall ...
DOI:
10.1007/s00018-022-04355-6

9. How Shockwaves Open Tight Junctions of Blood–Brain Barrier: Comparison of Three Biomechanical Effects

Author:
Tong Wei; Mi Zhou; Lingzhi Gu; Yang Zhou; Ming Li
Source:
Journal of physical chemistry 2022 v.126 no.27 pp. 5094-5102
ISSN:
1520-5207
Subject:
endothelial cells,   etc   ; biomechanics; blood-brain barrier; brain damage; drugs; molecular dynamics; therapeutics; tight junctions;     Show all 8 Subjects
Abstract:
... Revealing how blast shockwaves open the tight junction of the blood–brain barrier (BBB) is very important for understanding blast-induced traumatic brain injury (bTBI) and shockwave-assisted drug delivery; however, the underlying mechanism remains unresolved. Here, we used multiscale molecular dynamics simulations to reveal the disruption mechanism of claudin-5 protein in a relatively complex BBB ...
DOI:
10.1021/acs.jpcb.2c02903

10. Is Mitochondrial Oxidative Stress a Viable Therapeutic Target in Preeclampsia?

Author:
Ramana Vaka; Evangeline Deer; Babbette LaMarca
Source:
Antioxidants 2022 v.11 no.2 pp. -
ISSN:
2076-3921
Subject:
endothelial cells,   etc   ; ascorbic acid; mitochondria; oxidative stress; pathogenesis; patients; pre-eclampsia; therapeutics; vitamin E;     Show all 9 Subjects
Abstract:
... Despite considerable research efforts over the past few decades, the pathology of preeclampsia (PE) remains poorly understood with no new FDA-approved treatments. There is a substantial amount of work being conducted by investigators around the world to identify targets to develop therapies for PE. Oxidative stress has been identified as one of the crucial players in pathogenesis of PE and has gar ...
DOI:
10.3390/antiox11020210

11. Substrate stiffening promotes VEGF-A functions via the PI3K/Akt/mTOR pathway

Author:
Amjad Husain; Arogya Khadka; Allen Ehrlicher; Magali Saint-Geniez; Ramaswamy Krishnan
Source:
Biochemical and biophysical research communications 2022 v.586 pp. 27-33
ISSN:
0006-291X
Subject:
endothelial cells,   etc   ; angiogenesis; epithelium; macular degeneration; research; secretion; therapeutics; vascular endothelial growth factor A;     Show all 8 Subjects
Abstract:
... While it is now well-established that substrate stiffness regulates vascular endothelial growth factor-A (VEGF-A) mediated signaling and functions, causal mechanisms remain poorly understood. Here, we report an underlying role for the PI3K/Akt/mTOR signaling pathway. This pathway is activated on stiffer substrates, is amplified by VEGF-A stimulation, and correlates with enhanced endothelial cell ( ...
DOI:
10.1016/j.bbrc.2021.11.030

12. Bacterial responsive hydrogels based on quaternized chitosan and GQDs-ε-PL for chemo-photothermal synergistic anti-infection in diabetic wounds

Author:
Cui Cheng; Haowei Zhong; Yuan Zhang; Xiaoran Gao; Jianmin Wang; Jingfeng Liu; Xiao Han
Source:
International journal of biological macromolecules 2022 v.210 pp. 377-393
ISSN:
0141-8130
Subject:
endothelial cells,   etc   ; adhesion; antibiotics; chitosan; crosslinking; drug therapy; fibroblasts; graphene; hydrogels; imines; pH; synergism; xenon;     Show all 13 Subjects
Abstract:
... Clinically, systemic antibiotic therapy and traditional dressings care are not satisfactory in treating chronic diabetic ulcers (DU). Therefore, we presented sprayable antibacterial hydrogel for effective treatment of DU by using antibacterial macromolecules (quaternized chitosan, QCS, Mn ≈ 1.5 × 10⁵), photothermal antibacterial nanoparticles (ε-poly-l-lysine grafted graphene quantum dots, GQDs-ε- ...
DOI:
10.1016/j.ijbiomac.2022.05.008

13. Allograft inflammatory factor-1 enhances inflammation and oxidative stress via the NF-κB pathway in diabetic kidney disease

Author:
Yuting Fu; Xingzhi Wang; Lei Zhang; Yiqun Ren; Lirong Hao
Source:
Biochemical and biophysical research communications 2022 v.614 pp. 63-69
ISSN:
0006-291X
Subject:
endothelial cells,   etc   ; allografting; animal models; caudal vein; inflammation; kidney diseases; kidneys; oxidative stress; research; transfection;     Show all 10 Subjects
Abstract:
... Inflammation and glomerular endothelial dysfunction promote diabetic kidney disease (DKD) progression, but the mechanisms are not fully understood. Allograft inflammatory factor-1 (AIF-1) is a protein that regulates inflammatory reactions and immune responses. This study aimed to explore the mechanism of AIF-1 in a DKD animal model and mouse renal glomerular endothelial cells (MRGECs). We injected ...
DOI:
10.1016/j.bbrc.2022.04.089

14. Lymphatic endothelial cell fate specification in the mammalian embryo: An historical perspective

Author:
Guillermo Oliver
Source:
Developmental biology 2022 v.482 pp. 44-54
ISSN:
0012-1606
Subject:
endothelial cells,   etc   ; animal models; buds; cell specificity; early development; genes; mammalian embryo; mice; stem cells;     Show all 9 Subjects
Abstract:
... Development of the mammalian lymphatic vasculature is a stepwise process requiring the specification of lymphatic endothelial cell progenitors in the embryonic veins, and their subsequent budding to give rise to most of the mature lymphatic vasculature. In mice, formation of the lymphatic vascular network starts inside the cardinal vein at around E9.5 when a subpopulation of venous endothelial cel ...
DOI:
10.1016/j.ydbio.2021.12.005

15. The Immunological Role of Vascular and Lymphatic Endothelial Cells in Filarial Infections

Author:
Magdalena Elżbieta Wysmołek; Ewa Długosz; Marcin Wiśniewski
Source:
Animals 2022 v.12 no.4 pp. -
ISSN:
2076-2615
Subject:
endothelial cells,   etc   ; Nematoda; adhesion; blood; cell lines; cell proliferation; coculture; endothelium; immune response; mice; microfilariae; periodicity;     Show all 12 Subjects
Abstract:
... The embryonic stage of filarial nematodes, or microfilariae (Mf), shows daily and seasonal periodicity that requires their migration through blood vessels into the lungs, where they are sequestered when not circulating in the peripheral blood. Therefore, Mf and the host endothelium are likely in a permanent state of hide and seek. Interestingly, filarial nematodes co-cultured in media with a murin ...
DOI:
10.3390/ani12040426

16. Stable and direct coating of fibronectin-derived Leu-Asp-Val peptide on ePTFE using one-pot tyrosine oxidation for endothelial cell adhesion

Author:
Sachiro Kakinoki; Satoru Nishioka; Yuki Arichi; Tetsuji Yamaoka
Source:
Colloids and surfaces 2022 v.216 pp. 112576
ISSN:
0927-7765
Subject:
endothelial cells,   etc   ; adhesion; animal models; carotid arteries; cell adhesion; integrins; ligands; manufacturing; oxidation; peptides; polytetrafluoroethylene; tyrosine;     Show all 12 Subjects
Abstract:
... Expanded polytetrafluoroethylene (ePTFE) is widely used in clinical applications, such as in the manufacture of blood-contacting implantable devices, owing to its flexibility, biostability, and non-adhesiveness. Modification with peptides is an effective strategy to further improve the ePTFE function. However, the chemical stability of PTFE makes it difficult to modify with peptides. In this study ...
DOI:
10.1016/j.colsurfb.2022.112576

17. ApoE-mediated systemic nanodelivery of granzyme B and CpG for enhanced glioma immunotherapy

Author:
Jingjing Wei; Di Wu; Yu Shao; Beibei Guo; Jingjing Jiang; Jian Chen; Jinping Zhang; Fenghua Meng; Zhiyuan Zhong
Source:
Journal of controlled release 2022 v.347 pp. 68-77
ISSN:
0168-3659
Subject:
endothelial cells,   etc   ; brain; cell death; cytokines; cytotoxicity; glioma; immunotherapy; macrophages; mice; models; neoplasm progression; oligodeoxyribonucleotides; phenotype;     Show all 13 Subjects
Abstract:
... The response of malignant glioma to immunotherapy remains gloomy due to its discrete immunological environment and poor brain penetration of immunotherapeutic agents. Here, we disclose that ApoE peptide-mediated systemic nanodelivery of granzyme B (GrB) and CpG ODN co-stimulates enhanced immunotherapy of murine malignant LCPN glioma model. ApoE peptide-functionalized polymersomes encapsulating GrB ...
DOI:
10.1016/j.jconrel.2022.04.048

18. FVIII regulates the molecular profile of endothelial cells: functional impact on the blood barrier and macrophage behavior

Author:
Marie Cadé; Javier Muñoz-Garcia; Antoine Babuty; Louis Paré; Denis Cochonneau; Karim Fekir; Mathias Chatelais; Marie-Françoise Heymann; Anna Lokajczyk; Catherine Boisson-Vidal; Dominique Heymann
Source:
Cellular and molecular life sciences 2022 v.79 no.3 pp. 145
ISSN:
1420-682X
Subject:
endothelial cells,   etc   ; adhesion; cell adhesion; endothelium; extracellular matrix; hemophilia; humans; inflammation; macrophages; monocytes; osteopenia; permeability; thrombin; transcriptomics;     Show all 14 Subjects
Abstract:
... Hemophilia A is an inherited X-linked recessive bleeding disorder caused by deficient activity of blood coagulation factor VIII (FVIII). In addition, hemophilia patients show associated diseases including osteopenia, altered inflammation and vascular fragility which may represent the consequence of recurrent bleeding or may be related to the direct FVIII deficiency. Nowadays, recombinant FVIII is ...
DOI:
10.1007/s00018-022-04178-5

19. Neuron-derived neurotrophic factor protects against dexamethasone-induced skeletal muscle atrophy

Author:
Yuta Ozaki; Koji Ohashi; Naoya Otaka; Hayato Ogawa; Hiroshi Kawanishi; Tomonobu Takikawa; Lixin Fang; Minako Tatsumi; Mikito Takefuji; Takashi Enomoto; Mohamed Darwish; Yoko Iijima; Takatoshi Iijima; Toyoaki Murohara; Noriyuki Ouchi
Source:
Biochemical and biophysical research communications 2022 v.593 pp. 5-12
ISSN:
0006-291X
Subject:
endothelial cells,   etc   ; Adenoviridae; cardiomyocytes; dexamethasone; muscles; muscular atrophy; myotubes; nerve tissue; phosphorylation; research; skeletal muscle; therapeutics; ubiquitin;     Show all 13 Subjects
Abstract:
... Skeletal muscle atrophy caused by various conditions including aging, nerve damage, and steroid administration, is a serious health problem worldwide. We recently reported that neuron-derived neurotrophic factor (NDNF) functions as a muscle-derived secreted factor, also known as myokine, which exerts protective actions on endothelial cell and cardiomyocyte function. Here, we investigated whether N ...
DOI:
10.1016/j.bbrc.2022.01.028

20. CD93 a potential player in cytotrophoblast and endothelial cell migration

Author:
Sonia Fantone; Giovanni Tossetta; Nicoletta Di Simone; Chiara Tersigni; Giovanni Scambia; Fabio Marcheggiani; Stefano R. Giannubilo; Daniela Marzioni
Source:
Cell and tissue research 2022 v.387 no.1 pp. 123-130
ISSN:
0302-766X
Subject:
endothelial cells,   etc   ; cell movement; cell proliferation; complement; immunohistochemistry; monocytes; neuroglia; neutrophils; oxidative stress; pregnancy; protein synthesis; research;     Show all 12 Subjects
Abstract:
... CD93, also known as complement component C1q receptor, is expressed on the surface of different cellular types such as monocytes, neutrophils, platelets, microglia, and endothelial cells, and it plays a pivotal role in cell proliferation, cell migration, and formation of capillary-like structures. These processes are strictly regulated, and many fetal and maternal players are involved during place ...
DOI:
10.1007/s00441-021-03543-3