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Ken Kok; Chi-Lin Kuo; Rebecca E. Katzy; Lindsey T. Lelieveld; Liang Wu; Véronique Roig-Zamboni; Gijsbert A. van der Marel; Jeroen D. C. Codée; Gerlind Sulzenbacher; Gideon J. Davies; Herman S. Overkleeft; Johannes M. F. G. Aerts; Marta Artola
enzymeinhibitors, etc ; Danio rerio; ceramide glucosyltransferase; diabetes; humans; intestines; lysosomes; stabilizers; therapeutics; Show all 9 Subjects
Abstract:
... α-Glucosidase inhibitors are potential therapeutics for the treatment of diabetes, viral infections, and Pompe disease. Herein, we report a 1,6-epi-cyclophellitol cyclosulfamidate as a new class of reversible α-glucosidase inhibitors that displays enzyme inhibitory activity by virtue of its conformational mimicry of the substrate when bound in the Michaelis complex. The α-d-glc-configured cyclophe ...
... In Mexico, local ripened cheeses such as Chihuahua, Ranchero, and Cotija are produced, being consumed in great quantities together with imported cheeses. Proteolysis that takes place during ripening generates bioactive peptides; in this way the cheese acquires potential as a functional food. The ripening process of Gouda cheese was studied based on its bromatological and sensorial properties, bioa ...
... This study aimed to develop fermented spinach juice with enhanced γ‐aminobutyric acid (GABA) level and angiotensin‐converting enzyme (ACE) inhibitory activity and reduced oxalic acid level. We cofermented spinach juice with Levilactobacillus brevis GABA100 and oxalic acid‐degrading bacteria (Lactobacillus gasseri HHuMin D, Lactobacillus sakei RH1114, Lactobacillus acidophilus 19L5, or Limosilactob ...
... Systemic arterial hypertension is a health condition causing target organ damage (TOD) in dogs. Early and effective treatment is essential to prevent hypertensive emergencies and to reduce the risk of TOD. This study investigated the diseases underlying hypertension and compared the short-term efficacy of antihypertensive drugs in dogs. We evaluated the medical records of client-owned dogs treated ...
angiotensin-converting enzymeinhibitors, etc ; antioxidant activity; bioavailability; blood flow; breast milk; digestion; food chemistry; human cell lines; humans; intestines; milk; peptides; Show all 12 Subjects
Abstract:
... Human milk-protein-derived peptides exhibit an array of bioactivities. Certain bioactivities cannot be exerted unless the peptides are absorbed across the gastrointestinal lumen into the bloodstream. The purpose of study was to determine which peptides derived from in vitro digestion of human milk could cross human intestinal Caco-2 cell monolayers. Our results showed that the numbers of peptides ...
... The current study accentuates the significance of performing the multiplex approach of LC-HRESIMS, biological activity, and docking studies in drug discovery, taking into consideration a review of the literature. In this regard, the investigation of antioxidant and cytotoxic activities of Trigonella stellata collected from the Egyptian desert revealed a significant antioxidant capacity using DPPH ...
enzymeinhibitors, etc ; Ulva; Undaria pinnatifida; anion exchange; computer simulation; edible seaweed; energy; high performance liquid chromatography; hydrophobicity; macroalgae; peptides; purification methods; ultrafiltration; Show all 13 Subjects
Abstract:
... A number of functional foods containing seaweed-derived peptides are currently commercialized. Some seaweed derived peptide-containing products include Wakame peptide® and Nori peptide S®. To develop functional foods with the addition of Ulva spp. peptides, the isolation and identification of dipeptidyl peptidase IV (DPP-IV) inhibitory peptides from hydrolysates of this seaweed was performed. Ulva ...
enzymeinhibitors, etc ; Helicobacter pylori; antimicrobial properties; antioxidants; cell viability; constipation; defecation; fermentation; garlic; lactic acid; oral administration; peristalsis; probiotics; soy protein isolate; tofu; Show all 15 Subjects
Abstract:
... In this study, 3 lactic acid bacteria strains, Lactiplantibacillus plantarum X7021, X7022 and Limosilactobacillus fermentum S1L23, which were isolated from the brine of stinky tofu, were used to ferment black garlic stuff supplemented with 2% (w/v) soy protein isolate. The viable cell count of all strains could increase about 2 lg CFU/mL after 20 h of growth. The S-allyl-L-cysteine (SAC) content w ...
... To extend the application of celery (Apium graveolens L.) seeds, the antioxidant and enzymatic inhibitory activities of different fractions and their main flavones were investigated. The n-butanol fractions possessed the highest total phenolic content (TPC) and total flavonoid content (TFC) values. The n-butanol fractions from Northeast China samples exhibited the strongest free radical scavenging ...
... Seaweeds have a long history of use as both food and medicine, especially in Asian cultures. Moreover, there is growing interest in the use of seaweed ingredients and bioactive compounds in pharmaceutical and nutraceutical products. One ailment that seaweed bioactive compounds may impact is hypertension caused by the enzyme Angiotensin Converting Enzyme 1 (ACE-1; EC 3.4.15.1), found within the Ren ...
enzymeinhibitors, etc ; Rosa canina; anthocyanins; antioxidant activity; endo-1,4-beta-glucanase; enzyme inhibition; gallic acid; glycemic effect; molecular weight; multivariate analysis; polygalacturonase; rose hips; ultrasonic treatment; ultrasonics; Show all 14 Subjects
Abstract:
... Two techniques, namely, optimized ultrasound-assisted extraction (UAE) and enzyme-assisted extraction (EAE), were used to promote the extraction of phenolic compounds from the pseudo-fruits of Rosa canina L. (RC). For UAE, an optimization process based on the design of experiment (DoE) principles was used for determining the dependence between three variables (i.e., time of extraction, ultrasound ...
enzymeinhibitors, etc ; Araceae; butanol; chemical constituents of plants; chromatography; computer simulation; diabetes; enzyme inhibition; flavones; gastrointestinal system; iridoid glycosides; mass spectrometry; phenolic acids; snakes; urease; China; India; Pakistan; Show all 18 Subjects
Abstract:
... Sauromatum guttatum has been traditionally used in the treatment of snakebite and tumors in India, Pakistan, and China. However, it lacks detailed phytochemical composition like other members of the family Araceae. Therefore, the aim of the present study was to investigate the phytochemical composition of crude methanolic extract and subsequent fractions from S. guttatum tubers and to determine th ...
enzymeinhibitors, etc ; Aspergillus; Bivalvia; fungi; research; skeleton; spectroscopy; Show all 7 Subjects
Abstract:
... Two new compounds named asperpenes D (1) and E (2) were isolated from the marine-derived fungus Aspergillus sp. SCS-KFD66. Their structures were determined on the basis of spectroscopic methods. Compound 2 represents the first natural product bearing a 2-substituted-5-oxo-4-phenyl-2,5-dihydrofuran-3-carboxylic acid skeleton. All the compounds were tested for enzyme inhibitory activity against AChE ...
enzymeinhibitors, etc ; X-ray diffraction; carbonates; fungi; stereochemistry; Show all 5 Subjects
Abstract:
... A new tetrahydroanthraquinone (TAQ), ocauxarthrol A (1), as well as six known analogs, chrysoqueen (2), auxarthrols B (3), E (4), H (5), A (6), and paradictyoarthrin A (7), were isolated from the plateau soil-derived fungus Auxarthron umbrinum SCSIO 40432. X-ray crystallographic analyses were utilized to confirm the presence of a carbonate group in ocauxarthrol A (1) and to reassign the stereochem ...
enzymeinhibitors, etc ; angiotensin I; cheeses; collagen; fish; proteolysis; Show all 6 Subjects
Abstract:
... The effects of Illicium verum-, Psidium guajava-, or Curcuma longa- and/or fish collagen cheese on the proteolytic activity with anti-ACE activity were investigated during 0, 14, and 28 days of ripening. Two groups of plant-based cheeses were prepared. The first group contained plain cheese (control), I. verum-, P. guajava-, or C. longa-cheese. The second group contained plain cheese + fish collag ...
... Essential oils have been shown to effectively control vectors and intermediate hosts of disease transmission. The essential oil from the leaves of the Vietnamese species Callicarpa macrophylla was investigated for chemical composition, and evaluated for the pesticidal activities of both the essential oil and its major components. The essential oils were obtained by hydrodistillation (Clevenger app ...
enzymeinhibitors, etc ; Oriental traditional medicine; Tussilago farfara; analytical chemistry; antioxidant activity; antioxidants; chemical composition; chemical constituents of plants; flora; flowers; histology; light microscopy; medicinal plants; phenolic compounds; Europe; India; Show all 16 Subjects
Abstract:
... Tussilago farfara L., a perennial species, is a medicinal herb used in traditional medicine, mainly for the treatment of respiratory tract-related pathology. In traditional Chinese medicine, flower buds are preferred; in Europe, the leaves are used; and in some parts of India, the whole plant is utilized. This preferential usage of the plant organs might be based on differences in the chemical com ...
enzymeinhibitors, etc ; Escherichia coli; Staphylococcus aureus; antibacterial properties; antioxidant activity; beef; chemical composition; chickens; digestion; food research; gastrointestinal system; peptides; peptidomics; pork; principal component analysis; probiotics; processed meat; product development; Show all 18 Subjects
Abstract:
... Plant-based meat alternatives (PMAs) is a new type of food that meets people's health needs, but the lack of awareness of its nutritional properties limits product development and promotion. Here, we compared the similarities and differences of the nutritional properties of PMAs and meat before and after in vitro simulation of gastrointestinal digestion by chemical composition analysis, peptidomic ...
... Pilosella hoppeana subsp. cilicica has been traditionally used for healing many diseases in folk medicine in Anatolia. However, there are, to date, no studies aimed to verify this local usage with scientific data. In the present study, phenolic content and biological activities such as the antioxidant, antimicrobial and enzyme inhibition activities of different extracts of this plant’s aerial part ...
enzymeinhibitors, etc ; 4-hydroxybenzoic acid; Draba; alpha-amylase; antioxidants; bioactive properties; chemical constituents of plants; chlorogenic acid; chromatography; cosmetics; flavonoids; leaf extracts; leaves; medicine; polyphenols; rosmarinic acid; seed extracts; spectral analysis; Show all 18 Subjects
Abstract:
... Plant polyphenols have always attracted the attention of researchers with their excellent biological activity potentials. In this study, roots, leaves and seeds of Draba cemileae (Karaer) were evaluated for their chemical compositions and biological activities. Spectrophotometric analysis showed that phenolics and flavonoids were present in high quantities in leaf and seed extracts (22.84 mg GAEs/ ...