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1. Asperpenes D and E from the fungus Aspergillus sp. SCS-KFD66 isolated from a bivalve mollusk, Sanguinolaria chinensis

Author:
An, Chang-Liang; Kong, Fan-Dong; Li, Yan; Ma, Qing-Yun; Xie, Qing-Yi; Yuan, Jing-Zhe; Zhou, Li-Man; Dai, Hao-Fu; Yu, Zhi-Fang; Zhao, You-Xing
Source:
Journal of Asian natural products research 2021 v.23 no.2 pp. 117-122
ISSN:
1477-2213
Subject:
enzyme inhibitors,   etc   ; Aspergillus; Bivalvia; fungi; research; skeleton; spectroscopy;     Show all 7 Subjects
Abstract:
... Two new compounds named asperpenes D (1) and E (2) were isolated from the marine-derived fungus Aspergillus sp. SCS-KFD66. Their structures were determined on the basis of spectroscopic methods. Compound 2 represents the first natural product bearing a 2-substituted-5-oxo-4-phenyl-2,5-dihydrofuran-3-carboxylic acid skeleton. All the compounds were tested for enzyme inhibitory activity against AChE ...
DOI:
10.1080/10286020.2019.1709450

2. Correction: Suzuki coupling-based synthesis of VATPase inhibitor archazolid natural product derived fragments

Author:
Vincent, Cooper A.; Long, Evan T.; Jones, Holly C.; Young, Jeffrey C.; Spiegel, P. Clint; O’Neil, Gregory W.
Source:
RSC advances 2019 v.9 no.60 pp. 34963
ISSN:
2046-2069
Subject:
enzyme inhibitors
Abstract:
... Correction for ‘Suzuki coupling-based synthesis of VATPase inhibitor archazolid natural product derived fragments’ by Cooper T. Vincent et al., RSC Adv., 2019, 9, 32210–32218. ...
DOI:
10.1039/c9ra90080b

3. Comparative study on the structure, physicochemical, and functional properties of dietary fiber extracts from quinoa and wheat

Author:
Chen, Hong; Xiong, Min; Bai, Tingmei; Chen, Daiwen; Zhang, Qing; Lin, Derong; Liu, Yuntao; Liu, Aiping; Huang, Zhiqing; Qin, Wen
Source:
Lebensmittel-Wissenschaft + [i.e. und] Technologie 2021 v.149 pp. 111816
ISSN:
0023-6438
Subject:
enzyme inhibitors,   etc   ; alpha-amylase; antioxidants; comparative study; dietary fiber; polyphenols; polysaccharides; wheat;     Show all 8 Subjects
Abstract:
... Soluble and insoluble dietary fiber (SDF and IDF) were extracted from quinoa and wheat. Results showed that all the dietary fiber (DF) samples exhibited typical infrared spectrum characteristics of polysaccharides. Compared with wheat soluble dietary fiber (WHSDF), quinoa soluble dietary fiber (QUSDF) displayed a compact structure, higher reducing power and digestive enzyme inhibitory activity. WH ...
DOI:
10.1016/j.lwt.2021.111816

4. Evaluation of angiotensin-converting enzyme-inhibitory activity in abalone viscera fermented by Lactobacillus casei 001

Author:
Fujimura, Yushi; Shimura, Mariko; Nagai, Hiroshi; Hamada-Sato, Naoko
Source:
Journal of functional foods 2021 v.82 pp. 104474
ISSN:
1756-4646
Subject:
enzyme inhibitors,   etc   ; ; Lactobacillus casei; abalone; blood pressure; food industry; functional foods; lactic acid; peptidyl-dipeptidase A;     Show all 9 Subjects
Abstract:
... Abalone viscera are typically discarded in the food industry. This study evaluated the potential use of abalone viscera as a functional food. After fermentation by lactic acid bacteria, namely Lactobacillus casei 001, abalone viscera exhibited the ability to inhibit angiotensin-converting enzyme (ACE) and suppressed blood pressure increases in healthy mice and spontaneously hypertensive rats. Puri ...
DOI:
10.1016/j.jff.2021.104474

5. Ligand fishing based on bioaffinity ultrafiltration for screening xanthine oxidase inhibitors from citrus plants

Author:
Dong, Xin; Wang, Bin; Cao, Jun; Zheng, Hui; Ye, Li‐Hong
Source:
Journal of separation science 2021 v.44 no.7 pp. 1353-1360
ISSN:
1615-9306
Subject:
enzyme inhibitors,   etc   ; ; Citrus; allopurinol; hesperidin; ligands; mass spectrometry; naringin; separation; ultrafiltration; xanthine oxidase;     Show all 11 Subjects
Abstract:
... Citrus plants are valuable medicinal plants with abundant flavonoids content in the parts of fruits and peels, which exhibit potential hypouricemic effect. In the present study, a ligand fishing assay was performed based on bio‐affinity ultrafiltration for rapidly screening and identifying xanthine oxidase inhibitors from citrus plants. Under the optimal experimental conditions, five potential lig ...
DOI:
10.1002/jssc.202000708

6. New protein tyrosine phosphatase inhibitors from fungus Aspergillus gorakhpurensis F07ZB1707

Author:
Ji, Yannan; Zhou, Qiqi; Liu, Guosheng; Zhu, Tianhui; Wang, Yufang; Fu, Yan; Li, Yeying; Li, Ruolan; Zhang, Xuexia; Dong, Mei; Sauriol, Françoise; Gu, Yucheng; Shi, Qingwen; Lu, Xinhua; Ni, Zhiyu
Source:
RSC advances 2021 v.11 no.17 pp. 10144-10153
ISSN:
2046-2069
Subject:
enzyme inhibitors,   etc   ; Aspergillus; cytotoxicity; fungi; neoplasm cells; protein-tyrosine-phosphatase; spectral analysis; xanthone;     Show all 8 Subjects
Abstract:
... Twelve new compounds, aspergorakhins A–L (1–12) coupled with one known xanthone leptosphaerin D (13), were isolated from the extract of soil-derived fungus Aspergillus gorakhpurensis F07ZB1707. Their structures were elucidated by spectroscopic data analysis including UV, IR, NMR, and HRESIMS. The absolute configurations of 5 and 8–11 were identified using ECD and OR calculations. All compounds wer ...
DOI:
10.1039/d1ra00788b

7. A Tumor-Agnostic NTRK (TRK) Inhibitor

Author:
Huang, Franklin W.; Feng, Felix Y.
Source:
Cell 2019 v.177 no.1 pp. 8
ISSN:
0092-8674
Subject:
enzyme inhibitors,   etc   ; genomics; neoplasms;     Show all 3 Subjects
Abstract:
... Larotrectinib is a small-molecule kinase inhibitor that targets NTRK fusions that occur in multiple types of cancer. Its FDA approval represents the first instance of a treatment indication being designated “tumor-agnostic” from the outset, being based on actionable genomic insights. To view this Bench to Bedside, open or download the PDF. ...
DOI:
10.1016/j.cell.2019.02.049

8. Gain and loss of antibiotic resistant genes in multidrug resistant bacteria: One Health perspective

Author:
Kim, Misung; Park, Jaeeun; Kang, Mingyeong; Yang, Jihye; Park, Woojun
Source:
The journal of microbiology 2021 v.59 no.6 pp. 535-545
ISSN:
1225-8873
Subject:
enzyme inhibitors,   etc   ; One Health initiative; antibiotic resistance; chromosomes; energy; horizontal gene transfer; multiple drug resistance; phage therapy; plasmids; wastewater treatment;     Show all 10 Subjects
Abstract:
... The emergence of multidrug resistance (MDR) has become a global health threat due to the increasing unnecessary use of antibiotics. Multidrug resistant bacteria occur mainly by accumulating resistance genes on mobile genetic elements (MGEs), made possible by horizontal gene transfer (HGT). Humans and animal guts along with natural and engineered environments such as wastewater treatment plants and ...
DOI:
10.1007/s12275-021-1085-9

9. Optimization of the drying process of autumn fruits rich in antioxidants: a study focusing on rosehip (Rosa canina L.) and sea buckthorn (Elaeagnus rhamnoides (L.) A. Nelson) and their bioactive properties

Author:
Moldovan, Cadmiel; Babotă, Mihai; Mocan, Andrei; Menghini, Luigi; Cesa, Stefania; Gavan, Alexandru; Sisea, Cristian; Vodnar, Dan C.; Dias, Maria Inês; Pereira, Carla; Ferreira, Isabel C. F. R.; Crişan, Gianina; Barros, Lillian
Source:
Food & function 2021 v.12 no.9 pp. 3939-3953
ISSN:
2042-650X
Subject:
enzyme inhibitors,   etc   ; Elaeagnus; Hippophae rhamnoides; Rosa canina; air temperature; antioxidant activity; autumn; economic valuation; rose hips; Romania;     Show all 10 Subjects
Abstract:
... Nowadays, it is very important to identify the traditional uses of different plants and to create the context in which new cultural or economic value is given to local resources. In this study, two wild fruits traditionally harvested in autumn in Romania were selected to investigate the effects of drying conditions on the chemical compositions and bioactivities exerted by the extracts and to selec ...
DOI:
10.1039/d0fo02783a

10. Supercritical and ultrasound‐assisted extracts from Pleurotus pulmonarius mushroom: chemical profiles, antioxidative, and enzyme‐inhibitory properties

Author:
Milovanovic, Ivan; Zengin, Gokhan; Maksimovic, Svetolik; Tadic, Vanja
Source:
Journal of the science of food and agriculture 2021 v.101 no.6 pp. 2284-2293
ISSN:
0022-5142
Subject:
enzyme inhibitors,   etc   ; ; Pleurotus pulmonarius; agriculture; amylases; antioxidant activity; antioxidants; carbon dioxide; ergosterol; medicinal fungi; mushrooms; solvents; ultrasonic treatment;     Show all 13 Subjects
Abstract:
... BACKGROUND: This study provides an insight into the impact of ultrasound‐assisted extraction with water as solvent (UAEW) and extraction by supercritical carbon dioxide (SC‐CO₂) with 5% EtOH on antioxidant and enzyme inhibitory activity in regard to the chemical profile of the edible and medicinal mushroom, Pleurotus pulmonarius. RESULTS: Extraction efficiency was between 0.36% and 63.32%, dependi ...
DOI:
10.1002/jsfa.10849

11. Onosma gracilis (Trautv.) and O. oreodoxa (Boiss. & Heldr.): Phytochemistry, in silico docking, antioxidant and enzyme inhibitory activities

Author:
Baltaci, Nurnehir; Aydogdu, Nida; Sarikurkcu, Cengiz; Tepe, Bektas
Source:
South African journal of botany 2021
ISSN:
0254-6299
Subject:
enzyme inhibitors,   etc   ; Onosma; acetylcholinesterase; alpha-amylase; antioxidant activity; cholinesterase; chromatography; computer simulation; free radicals; hesperidin; methanol; rosmarinic acid;     Show all 12 Subjects
Abstract:
... In this study, it was aimed to determine the in vitro antioxidant and enzyme inhibitory activities of methanol (MeOH) extracts isolated from Onosma gracilis (Trautv.) and O. oreodoxa (Boiss. & Heldr.). O. oreodoxa was found to be richer in both phenolics and flavonoids than O. gracilis. The amounts of total phenolics and flavonoids in O. oreodoxa were 53.76 mg GAEs/g and 25.29 mg QEs/g, respective ...
DOI:
10.1016/j.sajb.2021.03.022

12. Host Cell Wall Damage during Pathogen Infection: Mechanisms of Perception and Role in Plant-Pathogen Interactions

Author:
Lorrai, Riccardo; Ferrari, Simone
Source:
Plants 2021 v.10 no.2
ISSN:
2223-7747
Subject:
enzyme inhibitors,   etc   ; cell walls; enzyme inhibition; enzymes; host-pathogen relationships; immune response; innate immunity; pathogen-associated molecular patterns; virulence;     Show all 9 Subjects
Abstract:
... The plant cell wall (CW) is a complex structure that acts as a mechanical barrier, restricting the access to most microbes. Phytopathogenic microorganisms can deploy an arsenal of CW-degrading enzymes (CWDEs) that are required for virulence. In turn, plants have evolved proteins able to inhibit the activity of specific microbial CWDEs, reducing CW damage and favoring the accumulation of CW-derived ...
DOI:
10.3390/plants10020399

13. Biscuits from Fermented Roasted Buckwheat Flour - Phenolics Profile and Bioaccessible Angiotensin Converting Enzyme Inhibitory Activity

Author:
Wronkowska, Małgorzata; Honke, Joanna; Zieliński, Henryk; Wiczkowski, Wiesław
Source:
Acta Universitatis Cibiniensis 2020 v.24 no.2 pp. 205-214
ISSN:
2344-150X
Subject:
enzyme inhibitors,   etc   ; ; buckwheat; buckwheat flour; digestion; epicatechin; fermentation; kaempferol;     Show all 8 Subjects
Abstract:
... The bioaccessible angiotensin converting enzyme (ACE) inhibitory activity of biscuits formulated from roasted common buckwheat flour after fermentation by select bacteria was studied. The same content of total phenolic compounds was found in fermented flour and in biscuits obtained from them. Generally, fermentation of flour did not changes the ACE inhibitory activity, whereas baking process signi ...
DOI:
10.2478/aucft-2020-0019

14. 2-Mercaptobenzoxazoles: a class of carbonic anhydrase inhibitors with a novel binding mode to the enzyme active site

Author:
Bozdag, Murat; Supuran, Claudiu T.; Esposito, Davide; Angeli, Andrea; Carta, Fabrizio; Monti, Simona Maria; De Simone, Giuseppina; Alterio, Vincenzo
Source:
Chemical communications 2020 v.56 no.59 pp. 8297-8300
ISSN:
1364-548X
Subject:
enzyme inhibitors,   etc   ; active sites; carbonate dehydratase; chemical compounds; chemical reactions;     Show all 5 Subjects
Abstract:
... 2-Mercaptobenzoxazole is a widely used organic scaffold in medicinal chemistry. By means of kinetic and structural studies, we demonstrate that this molecule can effectively be used to inhibit hCAs showing a peculiar binding mode. The results reported here can pave the way for the development of selective CA inhibitors. ...
DOI:
10.1039/d0cc02857f

15. SnapShot: Jak-STAT Signaling II

Author:
Villarino, Alejandro V.; Gadina, Massimo; O’Shea, John J.; Kanno, Yuka
Source:
Cell 2020 v.181 no.7 pp. 1696
ISSN:
0092-8674
Subject:
enzyme inhibitors,   etc   ; drugs; immunosuppression; protein kinases; signal transduction;     Show all 5 Subjects
Abstract:
... The JAK-STAT pathway is an evolutionarily conserved signal transduction paradigm, providing mechanisms for rapid receptor-to-nucleus communication and transcription control. Discoveries in this field provided insights into primary immunodeficiencies, inherited autoimmune and autoinflammatory diseases, and hematologic and oncologic disorders, giving rise to a new class of drugs, JAK inhibitors (or ...
DOI:
10.1016/j.cell.2020.04.052

16. Characteristics of a XIP‐resistant xylanase from Neocallimastix sp. GMLF1 and its advantage in barley malt saccharification

Author:
Zhu, Dongdong; Liu, Xinyu; Xie, Xia; Yang, Sen; Lin, Hui; Chen, Hongge
Source:
International journal of food science & technology 2020 v.55 no.5 pp. 2152-2160
ISSN:
0950-5423
Subject:
enzyme inhibitors,   etc   ; Neocallimastix; malting barley; proteins; saccharification; xylanases;     Show all 6 Subjects
Abstract:
... The well‐studied xylanase inhibitor protein (XIP‐I) regularly inhibits fungi‐derived xylanases, yet some fungal xylanases are not inhibited by XIP‐I. Based on the sequence alignment with the known XIP‐I resistant NpXyn11A from Neocallimastix patriciarum, a new annotated xylanase from ruminal fungus Neocallimastix sp. GMLF1 was found, noted as Xyn1B, which shared 77.8% of sequence identity with NpX ...
DOI:
10.1111/ijfs.14341

17. A phenotypic approach to probing cellular outcomes using heterobivalent constructs

Author:
Bhadoria, Rohit; Ping, Kefeng; Lohk, Christer; Järving, Ivar; Starkov, Pavel
Source:
Chemical communications 2020 v.56 no.30 pp. 4216-4219
ISSN:
1364-548X
Subject:
enzyme inhibitors,   etc   ; cell viability; chemical compounds; chemical reactions; enzymes; phenotype;     Show all 6 Subjects
Abstract:
... Various conjugation techniques are used to affect the intracellular delivery of bioactive small molecules. However, the ability to track changes in the phenotype when applying these tools remains poorly studied. We addressed this issue by having prepared a focused library of heterobivalent constructs based on Rho kinase inhibitor HA-100. By comparing the induction of the phenotype of interest, cel ...
DOI:
10.1039/c9cc09595k

18. Reductive sp³–sp² Coupling Reactions Enable Late-Stage Modification of Pharmaceuticals

Author:
Mennie, Katrina M.; Vara, Brandon A.; Levi, Samuel M.
Source:
Organic letters 2020 v.22 no.2 pp. 556-559
ISSN:
1523-7052
Subject:
enzyme inhibitors,   etc   ; derivatization; drugs; enzymes; moieties; organic halogen compounds;     Show all 6 Subjects
Abstract:
... Late-stage derivatization of pharmaceutically relevant scaffolds relies on the availability of highly functional-group tolerant reactions. Reactions that increase the sp³ character of molecules enable the pursuit of more selective and well-tolerated pharmaceuticals. Herein, we report the use of sp³–sp² cross-electrophile reductive couplings to modify a generic ATP-competitive kinase inhibitor with ...
DOI:
10.1021/acs.orglett.9b04320

19. Identification of fungal enzymes involving 3-phenoxybenzoic acid degradation by using enzymes inhibitors and inducers

Author:
Zhao, Jiayuan; Chen, Xiaofeng; Jia, Dongying; Yao, Kai
Source:
MethodsX 2020 v.7 pp. 100772
ISSN:
2215-0161
Subject:
enzyme inhibitors,   etc   ; benzoic acids; chemical structure; fungal enzymes;     Show all 4 Subjects
Abstract:
... Pyrethroid residues in food and the environment can be bio-transformed into 3-phenoxybenzoic acid (3-PBA); It is more toxic than the parent compounds, and has been detected in milk, soil, and human urine. In this study, when incubated at 30 °C and 180 rpm for 48 h, mycelial pellets during logarithmic growth phase were obtained and washed 2 times by phosphate buffer. The cell debris solutions and f ...
DOI:
10.1016/j.mex.2019.100772
PubMed:
32140437
PubMed Central:
PMC7046809

20. Screening natural product extracts for potential enzyme inhibitors: protocols, and the standardisation of the usage of blanks in α-amylase, α-glucosidase and lipase assays

Author:
Lankatillake, Chintha; Luo, Shiqi; Flavel, Matthew; Lenon, George Binh; Gill, Harsharn; Huynh, Tien; Dias, Daniel Anthony
Source:
Plant methods 2021 v.17 no.1 pp. 3
ISSN:
1746-4811
Subject:
enzyme inhibitors,   etc   ; accuracy; alpha-amylase; assays; carboxylic ester hydrolases; color; diabetes; drugs; enzyme inhibition; literature; obesity; plant extracts; protocols; reproducibility; research; sampling; screening; standardization; variability;     Show all 19 Subjects
Abstract:
... BACKGROUND: Enzyme assays have widespread applications in drug discovery from plants to natural products. The appropriate use of blanks in enzyme assays is important for assay baseline-correction, and the correction of false signals associated with background matrix interferences. However, the blank-correction procedures reported in published literature are highly inconsistent. We investigated the ...
DOI:
10.1186/s13007-020-00702-5