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1. 1,6-epi-Cyclophellitol Cyclosulfamidate Is a Bona Fide Lysosomal α-Glucosidase Stabilizer for the Treatment of Pompe Disease

Author:
Ken Kok; Chi-Lin Kuo; Rebecca E. Katzy; Lindsey T. Lelieveld; Liang Wu; Véronique Roig-Zamboni; Gijsbert A. van der Marel; Jeroen D. C. Codée; Gerlind Sulzenbacher; Gideon J. Davies; Herman S. Overkleeft; Johannes M. F. G. Aerts; Marta Artola
Source:
Journal of the American Chemical Society 2022 v.144 no.32 pp. 14819-14827
ISSN:
1520-5126
Subject:
enzyme inhibitors,   etc   ; Danio rerio; ceramide glucosyltransferase; diabetes; humans; intestines; lysosomes; stabilizers; therapeutics;     Show all 9 Subjects
Abstract:
... α-Glucosidase inhibitors are potential therapeutics for the treatment of diabetes, viral infections, and Pompe disease. Herein, we report a 1,6-epi-cyclophellitol cyclosulfamidate as a new class of reversible α-glucosidase inhibitors that displays enzyme inhibitory activity by virtue of its conformational mimicry of the substrate when bound in the Michaelis complex. The α-d-glc-configured cyclophe ...
DOI:
10.1021/jacs.2c05666

2. Antioxidant and antihypertensive activity of Gouda cheese at different stages of ripening

Author:
Lucibel Álvarez Ramos; Daniel Arrieta Baez; Gloria Dávila Ortiz; Jorge Carlos Ruiz Ruiz; Víctor Manuel Toledo López
Source:
Food chemistry: X 2022 v.14 pp. 100284
ISSN:
2590-1575
Subject:
enzyme inhibitors,   etc   ; Gouda cheese; antihypertensive effect; antioxidants; dairy industry; food chemistry; functional foods; peptides; peptidyl-dipeptidase A; proteolysis; Mexico;     Show all 11 Subjects
Abstract:
... In Mexico, local ripened cheeses such as Chihuahua, Ranchero, and Cotija are produced, being consumed in great quantities together with imported cheeses. Proteolysis that takes place during ripening generates bioactive peptides; in this way the cheese acquires potential as a functional food. The ripening process of Gouda cheese was studied based on its bromatological and sensorial properties, bioa ...
DOI:
10.1016/j.fochx.2022.100284

3. γ‐Aminobutyric acid and oxalic acid contents and angiotensin‐converting enzyme inhibitory activity of spinach juices cofermented with Levilactobacillus brevis GABA100 and other lactic acid bacteria

Author:
Moon Joo Kim; Taehwan Lim; Jaecheol Kim; Geun Eog Ji; Haeseong Lee; Kiuk Lee; Ryun Hee Kim; Keum Taek Hwang
Source:
International journal of food science & technology 2022 v.57 no.10 pp. 6722-6729
ISSN:
0950-5423
Subject:
enzyme inhibitors,   etc   ; Lactobacillus acidophilus; Lactobacillus gasseri; Lactobacillus sakei; fermentation; food science; hypertension; juices; oxalic acid; peptides; peptidyl-dipeptidase A; spinach;     Show all 12 Subjects
Abstract:
... This study aimed to develop fermented spinach juice with enhanced γ‐aminobutyric acid (GABA) level and angiotensin‐converting enzyme (ACE) inhibitory activity and reduced oxalic acid level. We cofermented spinach juice with Levilactobacillus brevis GABA100 and oxalic acid‐degrading bacteria (Lactobacillus gasseri HHuMin D, Lactobacillus sakei RH1114, Lactobacillus acidophilus 19L5, or Limosilactob ...
DOI:
10.1111/ijfs.16030

4. Comparative Efficacy of Antihypertensive Drugs in Dogs: A Systematic Review

Author:
Hyeong-Il Choi; Joonyoung Kim; In-Sik Shin; Ha-Jung Kim
Source:
Topics in companion animal medicine 2022 v.50 pp. 100674
ISSN:
1938-9736
Subject:
angiotensin-converting enzyme inhibitors,   etc   ; calcium channel blockers; hyperadrenocorticism; hypertension; medicine; pets; risk reduction; systematic review; systolic blood pressure; telmisartan; therapeutics;     Show all 11 Subjects
Abstract:
... Systemic arterial hypertension is a health condition causing target organ damage (TOD) in dogs. Early and effective treatment is essential to prevent hypertensive emergencies and to reduce the risk of TOD. This study investigated the diseases underlying hypertension and compared the short-term efficacy of antihypertensive drugs in dogs. We evaluated the medical records of client-owned dogs treated ...
DOI:
10.1016/j.tcam.2022.100674

5. Bioavailability of Peptides Derived from the In Vitro Digestion of Human Milk Assessed by Caco-2 Cell Monolayers

Author:
Ningjian Liang; Bum Jin Kim; David C. Dallas
Source:
Journal of agricultural and food chemistry 2022 v.70 no.23 pp. 7077-7084
ISSN:
1520-5118
Subject:
angiotensin-converting enzyme inhibitors,   etc   ; antioxidant activity; bioavailability; blood flow; breast milk; digestion; food chemistry; human cell lines; humans; intestines; milk; peptides;     Show all 12 Subjects
Abstract:
... Human milk-protein-derived peptides exhibit an array of bioactivities. Certain bioactivities cannot be exerted unless the peptides are absorbed across the gastrointestinal lumen into the bloodstream. The purpose of study was to determine which peptides derived from in vitro digestion of human milk could cross human intestinal Caco-2 cell monolayers. Our results showed that the numbers of peptides ...
DOI:
10.1021/acs.jafc.2c01246
CHORUS:
10.1021/acs.jafc.2c01246

6. Characterization of Possible α-Glucosidase Inhibitors from Trigonella stellata Extract Using LC–MS and In Silico Molecular Docking

Author:
Ahlam Elwekeel; Dalia El Amir; Enas I. A. Mohamed; Elham Amin; Marwa H. A. Hassan; Mohamed A. Zaki
Source:
Plants 2022 v.11 no.2 pp. -
ISSN:
2223-7747
Subject:
enzyme inhibitors,   etc   ; Trigonella; acarbose; alkaloids; alpha-amylase; antioxidant activity; antioxidants; computer simulation; cytotoxicity; diterpenoids; drugs; gallic acid; glycemic effect; glycosides; metabolites; rutin;     Show all 16 Subjects
Abstract:
... The current study accentuates the significance of performing the multiplex approach of LC-HRESIMS, biological activity, and docking studies in drug discovery, taking into consideration a review of the literature. In this regard, the investigation of antioxidant and cytotoxic activities of Trigonella stellata collected from the Egyptian desert revealed a significant antioxidant capacity using DPPH ...
DOI:
10.3390/plants11020208

7. Identification and in silico study of a novel dipeptidyl peptidase IV inhibitory peptide derived from green seaweed Ulva spp. hydrolysates

Author:
Raúl E. Cian; Agustina E. Nardo; Antonela G. Garzón; María C. Añon; Silvina R. Drago
Source:
Lebensmittel-Wissenschaft + Technologie 2022 v.154 pp. 112738
ISSN:
0023-6438
Subject:
enzyme inhibitors,   etc   ; Ulva; Undaria pinnatifida; anion exchange; computer simulation; edible seaweed; energy; high performance liquid chromatography; hydrophobicity; macroalgae; peptides; purification methods; ultrafiltration;     Show all 13 Subjects
Abstract:
... A number of functional foods containing seaweed-derived peptides are currently commercialized. Some seaweed derived peptide-containing products include Wakame peptide® and Nori peptide S®. To develop functional foods with the addition of Ulva spp. peptides, the isolation and identification of dipeptidyl peptidase IV (DPP-IV) inhibitory peptides from hydrolysates of this seaweed was performed. Ulva ...
DOI:
10.1016/j.lwt.2021.112738

8. Improvement of S-allyl-L-cysteine content, probiotic properties and constipation prevention effect of black garlic by the lactic acid bacteria fermentation

Author:
Kum-Song Ro; Ying Chen; Lei Du; Lixin Wang; Li Zhao; Jingli Xie; Dongzhi Wei
Source:
Process biochemistry 2022 v.115 pp. 110-117
ISSN:
1359-5113
Subject:
enzyme inhibitors,   etc   ; Helicobacter pylori; antimicrobial properties; antioxidants; cell viability; constipation; defecation; fermentation; garlic; lactic acid; oral administration; peristalsis; probiotics; soy protein isolate; tofu;     Show all 15 Subjects
Abstract:
... In this study, 3 lactic acid bacteria strains, Lactiplantibacillus plantarum X7021, X7022 and Limosilactobacillus fermentum S1L23, which were isolated from the brine of stinky tofu, were used to ferment black garlic stuff supplemented with 2% (w/v) soy protein isolate. The viable cell count of all strains could increase about 2 lg CFU/mL after 20 h of growth. The S-allyl-L-cysteine (SAC) content w ...
DOI:
10.1016/j.procbio.2022.02.009

9. Antioxidant Capacities and Enzymatic Inhibitory Effects of Different Solvent Fractions and Major Flavones from Celery Seeds Produced in Different Geographic Areas in China

Author:
Chao Zhang; Jing Yu; Qiang Tu; Fu Yan; Zhao Hu; Youming Zhang; Chun Song
Source:
Antioxidants 2022 v.11 no.8 pp. -
ISSN:
2076-3921
Subject:
enzyme inhibitors,   etc   ; Apium graveolens; EDTA (chelating agent); antioxidant activity; antioxidants; apigenin; butanol; celery; enzymes; free radicals; glycosides; hyperglycemia; methylene chloride; seeds; solvents; China;     Show all 16 Subjects
Abstract:
... To extend the application of celery (Apium graveolens L.) seeds, the antioxidant and enzymatic inhibitory activities of different fractions and their main flavones were investigated. The n-butanol fractions possessed the highest total phenolic content (TPC) and total flavonoid content (TFC) values. The n-butanol fractions from Northeast China samples exhibited the strongest free radical scavenging ...
DOI:
10.3390/antiox11081542

10. Angiotensin-I-Converting Enzyme Inhibitory Activity of Protein Hydrolysates Generated from the Macroalga Laminaria digitata (Hudson) JV Lamouroux 1813

Author:
Diane Purcell; Michael A. Packer; Maria Hayes
Source:
Foods 2022 v.11 no.12 pp. -
ISSN:
2304-8158
Subject:
enzyme inhibitors,   etc   ; Laminaria digitata; aldosterone; blood; cell walls; dietary supplements; drugs; enzymatic hydrolysis; filtration; hydrolysates; hydrolysis; hypertension; macroalgae; medicine; peptides; peptidyl-dipeptidase A; protein content; proteolysis; vasoconstriction;     Show all 19 Subjects
Abstract:
... Seaweeds have a long history of use as both food and medicine, especially in Asian cultures. Moreover, there is growing interest in the use of seaweed ingredients and bioactive compounds in pharmaceutical and nutraceutical products. One ailment that seaweed bioactive compounds may impact is hypertension caused by the enzyme Angiotensin Converting Enzyme 1 (ACE-1; EC 3.4.15.1), found within the Ren ...
DOI:
10.3390/foods11121792

11. Optimized Ultrasound-Assisted Enzymatic Extraction of Phenolic Compounds from Rosa canina L. Pseudo-Fruits (Rosehip) and Their Biological Activity

Author:
Alexandru Nicolescu; Mihai Babotă; Leilei Zhang; Claudiu I. Bunea; Laura Gavrilaș; Dan C. Vodnar; Andrei Mocan; Gianina Crișan; Gabriele Rocchetti
Source:
Antioxidants 2022 v.11 no.6 pp. -
ISSN:
2076-3921
Subject:
enzyme inhibitors,   etc   ; Rosa canina; anthocyanins; antioxidant activity; endo-1,4-beta-glucanase; enzyme inhibition; gallic acid; glycemic effect; molecular weight; multivariate analysis; polygalacturonase; rose hips; ultrasonic treatment; ultrasonics;     Show all 14 Subjects
Abstract:
... Two techniques, namely, optimized ultrasound-assisted extraction (UAE) and enzyme-assisted extraction (EAE), were used to promote the extraction of phenolic compounds from the pseudo-fruits of Rosa canina L. (RC). For UAE, an optimization process based on the design of experiment (DoE) principles was used for determining the dependence between three variables (i.e., time of extraction, ultrasound ...
DOI:
10.3390/antiox11061123

12. Tandem high resolution mass spectrometry based phytochemical composition of Sauromatum guttatum tubers and its enzyme inhibitory potential with molecular docking

Author:
Kashif Bashir; Sadia Naz; Hafiz Majid Rasheed; Umar Farooq; Abdul Jabbar Shah; Erin P. McCauley; Phillip Crews; Taous Khan
Source:
Journal of chromatography 2022 v.1672 pp. 463055
ISSN:
0021-9673
Subject:
enzyme inhibitors,   etc   ; Araceae; butanol; chemical constituents of plants; chromatography; computer simulation; diabetes; enzyme inhibition; flavones; gastrointestinal system; iridoid glycosides; mass spectrometry; phenolic acids; snakes; urease; China; India; Pakistan;     Show all 18 Subjects
Abstract:
... Sauromatum guttatum has been traditionally used in the treatment of snakebite and tumors in India, Pakistan, and China. However, it lacks detailed phytochemical composition like other members of the family Araceae. Therefore, the aim of the present study was to investigate the phytochemical composition of crude methanolic extract and subsequent fractions from S. guttatum tubers and to determine th ...
DOI:
10.1016/j.chroma.2022.463055

13. Asperpenes D and E from the fungus Aspergillus sp. SCS-KFD66 isolated from a bivalve mollusk, Sanguinolaria chinensis

Author:
Chang-Liang An; Fan-Dong Kong; Yan Li; Qing-Yun Ma; Qing-Yi Xie; Jing-Zhe Yuan; Li-Man Zhou; Hao-Fu Dai; Zhi-Fang Yu; You-Xing Zhao
Source:
Journal of Asian natural products research 2021 v.23 no.2 pp. 117-122
ISSN:
1477-2213
Subject:
enzyme inhibitors,   etc   ; Aspergillus; Bivalvia; fungi; research; skeleton; spectroscopy;     Show all 7 Subjects
Abstract:
... Two new compounds named asperpenes D (1) and E (2) were isolated from the marine-derived fungus Aspergillus sp. SCS-KFD66. Their structures were determined on the basis of spectroscopic methods. Compound 2 represents the first natural product bearing a 2-substituted-5-oxo-4-phenyl-2,5-dihydrofuran-3-carboxylic acid skeleton. All the compounds were tested for enzyme inhibitory activity against AChE ...
DOI:
10.1080/10286020.2019.1709450

14. Ocauxarthrol A from Auxarthron umbrinum SCSIO 40432 and configurational reassignment of chrysoqueen and auxarthrols

Author:
Hui-Xin Xu; Ting Yang; Li-Ping Zhang; Wei Liu; Hai-Bo Zhang; Qing-Bo Zhang; Chang-Sheng Zhang; Wen-Jun Zhang
Source:
Tetrahedron letters 2021 v.66 pp. 152842
ISSN:
0040-4039
Subject:
enzyme inhibitors,   etc   ; X-ray diffraction; carbonates; fungi; stereochemistry;     Show all 5 Subjects
Abstract:
... A new tetrahydroanthraquinone (TAQ), ocauxarthrol A (1), as well as six known analogs, chrysoqueen (2), auxarthrols B (3), E (4), H (5), A (6), and paradictyoarthrin A (7), were isolated from the plateau soil-derived fungus Auxarthron umbrinum SCSIO 40432. X-ray crystallographic analyses were utilized to confirm the presence of a carbonate group in ocauxarthrol A (1) and to reassign the stereochem ...
DOI:
10.1016/j.tetlet.2021.152842

15. Effects of medicinal plants extract enriched cheese with fish collagen on proteolysis and in vitro angiotensin-I converting enzyme inhibitory activity

Author:
Amal Bakr Shori; Yeoh Shin Yong; Ahmad Salihin Baba
Source:
Lebensmittel-Wissenschaft + Technologie 2022 v.159 pp. 113218
ISSN:
0023-6438
Subject:
enzyme inhibitors,   etc   ; angiotensin I; cheeses; collagen; fish; proteolysis;     Show all 6 Subjects
Abstract:
... The effects of Illicium verum-, Psidium guajava-, or Curcuma longa- and/or fish collagen cheese on the proteolytic activity with anti-ACE activity were investigated during 0, 14, and 28 days of ripening. Two groups of plant-based cheeses were prepared. The first group contained plain cheese (control), I. verum-, P. guajava-, or C. longa-cheese. The second group contained plain cheese + fish collag ...
DOI:
10.1016/j.lwt.2022.113218

16. Strong Larvicidal and Molluscicidal Activities of the (E)-β-caryophyllene-rich Chemotype of Callicarpa macrophylla Vah Leaf Essential Oil Growing Wild in Vietnam

Author:
Nguyen Huy Hung; Van The Pham; Prabodh Satyal; Ngo Gia Huy; Vo Van Hoa; Tran Thu Hien; Pham Minh Quan; William N. Setzer
Source:
Journal of essential oil-bearing plants 2022 v.25 no.3 pp. 666-680
ISSN:
0976-5026
Subject:
enzyme inhibitors,   etc   ; Aedes aegypti; Aedes albopictus; Callicarpa macrophylla; Diplonychus rusticus; Pomacea canaliculata; acetylcholinesterase; chemical composition; chemotypes; disease transmission; essential oils; hydrodistillation; larvae; larvicides; leaves; mortality; nontarget organisms; toxicity; Vietnam;     Show all 19 Subjects
Abstract:
... Essential oils have been shown to effectively control vectors and intermediate hosts of disease transmission. The essential oil from the leaves of the Vietnamese species Callicarpa macrophylla was investigated for chemical composition, and evaluated for the pesticidal activities of both the essential oil and its major components. The essential oils were obtained by hydrodistillation (Clevenger app ...
DOI:
10.1080/0972060X.2022.2104135

17. A Comparative Analysis of the Anatomy, Phenolic Profile, and Antioxidant Capacity of Tussilago farfara L. Vegetative Organs

Author:
Viviane Beatrice Bota; Andreea-Adriana Neamtu; Neli-Kinga Olah; Elisabeta Chișe; Ramona Flavia Burtescu; Flavia Roxana Pripon Furtuna; Alexandru-Sabin Nicula; Carmen Neamtu; Adrian-Marius Maghiar; Lăcrămioara-Carmen Ivănescu; Maria-Magdalena Zamfirache; Endre Mathe; Violeta Turcuș
Source:
Plants 2022 v.11 no.13 pp. -
ISSN:
2223-7747
Subject:
enzyme inhibitors,   etc   ; Oriental traditional medicine; Tussilago farfara; analytical chemistry; antioxidant activity; antioxidants; chemical composition; chemical constituents of plants; flora; flowers; histology; light microscopy; medicinal plants; phenolic compounds; Europe; India;     Show all 16 Subjects
Abstract:
... Tussilago farfara L., a perennial species, is a medicinal herb used in traditional medicine, mainly for the treatment of respiratory tract-related pathology. In traditional Chinese medicine, flower buds are preferred; in Europe, the leaves are used; and in some parts of India, the whole plant is utilized. This preferential usage of the plant organs might be based on differences in the chemical com ...
DOI:
10.3390/plants11131663

18. Peptidomics comparison of plant-based meat alternatives and processed meat after in vitro digestion

Author:
Zhuqing Xing; Jiaying Li; Yating Zhang; Ang Gao; Heran Xie; Zifan Gao; Xuan Chu; Yumeng Cai; Chunkai Gu
Source:
Food research international 2022 v.158 pp. 111462
ISSN:
0963-9969
Subject:
enzyme inhibitors,   etc   ; Escherichia coli; Staphylococcus aureus; antibacterial properties; antioxidant activity; beef; chemical composition; chickens; digestion; food research; gastrointestinal system; peptides; peptidomics; pork; principal component analysis; probiotics; processed meat; product development;     Show all 18 Subjects
Abstract:
... Plant-based meat alternatives (PMAs) is a new type of food that meets people's health needs, but the lack of awareness of its nutritional properties limits product development and promotion. Here, we compared the similarities and differences of the nutritional properties of PMAs and meat before and after in vitro simulation of gastrointestinal digestion by chemical composition analysis, peptidomic ...
DOI:
10.1016/j.foodres.2022.111462

19. Chemical profile, antioxidant, antimicrobial, and enzyme inhibition activities of Pilosella hoppeana subsp. cilicica

Author:
Tuba Acet
Source:
Plant biosystems 2022 v.156 no.2 pp. 553-559
ISSN:
1724-5575
Subject:
enzyme inhibitors,   etc   ; Enterococcus faecium; Listeria innocua; Pilosella; Proteus vulgaris; Staphylococcus epidermidis; Turkey (country); Yersinia pseudotuberculosis; aerial parts; alpha-amylase; antimicrobial properties; antioxidants; apigenin; chlorogenic acid; enzyme inhibition; luteolin; methanol; traditional medicine;     Show all 18 Subjects
Abstract:
... Pilosella hoppeana subsp. cilicica has been traditionally used for healing many diseases in folk medicine in Anatolia. However, there are, to date, no studies aimed to verify this local usage with scientific data. In the present study, phenolic content and biological activities such as the antioxidant, antimicrobial and enzyme inhibition activities of different extracts of this plant’s aerial part ...
DOI:
10.1080/11263504.2021.1894257

20. Draba cemileae (Karaer): Phytochemical composition, antioxidant and enzyme inhibitory activity

Author:
Mustafa Cuce; Ersin Demir; Arzuhan Sihoglu Tepe; Cengiz Sarikurkcu
Source:
South African journal of botany 2022 v.145 pp. 170-176
ISSN:
0254-6299
Subject:
enzyme inhibitors,   etc   ; 4-hydroxybenzoic acid; Draba; alpha-amylase; antioxidants; bioactive properties; chemical constituents of plants; chlorogenic acid; chromatography; cosmetics; flavonoids; leaf extracts; leaves; medicine; polyphenols; rosmarinic acid; seed extracts; spectral analysis;     Show all 18 Subjects
Abstract:
... Plant polyphenols have always attracted the attention of researchers with their excellent biological activity potentials. In this study, roots, leaves and seeds of Draba cemileae (Karaer) were evaluated for their chemical compositions and biological activities. Spectrophotometric analysis showed that phenolics and flavonoids were present in high quantities in leaf and seed extracts (22.84 mg GAEs/ ...
DOI:
10.1016/j.sajb.2021.07.028