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1. Natural stereoisomeric flavonoids exhibit different disruptive effects and the mechanism of action on Aβ₄₂ protofibril

Author:
Zhan, Chendi; Lao, Zenghui; Tang, Yiming; Qiao, Qin; Wei, Guanghong
Source:
Chemical communications 2021 v.57 no.35 pp. 4267-4270
ISSN:
1364-548X
Subject:
epicatechin,   etc   ; mechanism of action; stereoisomers;     Show all 3 Subjects
Abstract:
... Our simulations reveal that two enantiomeric catechins display a better disruptive effect on Aβ₄₂ protofibril than their stereoisomer epicatechin. Unexpectedly, we find that catechins adopt both collapsed and extended states, while epicatechin populates only an extended state. Their different protofibril-disruptive effects are mostly attributed to the steric effect caused by the conformational dif ...
DOI:
10.1039/d1cc00404b

2. Controllable synthesis of iron-polyphenol colloidal nanoparticles with composition-dependent photothermal performance

Author:
Qin, Jing; Liang, Guohai; Cheng, Dong; Liu, Yining; Cheng, Xiaoran; Yang, Pengkun; Wu, Na; Zhao, Yongxi; Wei, Jing
Source:
Journal of colloid and interface science 2021 v.593 pp. 172-181
ISSN:
0021-9797
Subject:
epicatechin,   etc   ; epigallocatechin gallate; gallic acid; ligands; neoplasms; particle size; photothermotherapy; proanthocyanidins; tannins;     Show all 9 Subjects
Abstract:
... Iron-polyphenol nanoparticles are usually prepared with nontoxic plant polyphenols as a main building block, which are an emerging photothermal agent for photothermal therapy. However, till now, few works have been made on the controllable synthesis of iron-polyphenol nanoparticles with tunable composition, as well as investigation of the relationship between material composition and photothermal ...
DOI:
10.1016/j.jcis.2021.02.082

3. Rapid screening of unground cocoa beans based on their content of bioactive compounds by NIR spectroscopy

Author:
Hernández-Hernández, Carolina; Fernández-Cabanás, Víctor M.; Rodríguez-Gutiérrez, Guillermo; Fernández-Prior, África; Morales-Sillero, Ana
Source:
Food control 2021 pp. 108347
ISSN:
0956-7135
Subject:
epicatechin,   etc   ; bioactive compounds; cotyledons; fermentation; food safety; germplasm; hulls; lipid content; near-infrared spectroscopy; theobromine;     Show all 10 Subjects
Abstract:
... Near Infrared (NIR) spectroscopy was evaluated as a fast and easy method for identifying the most interesting cocoa genotypes according to chemical composition, including bioactive compound contents, in more than 80 samples of cocoa beans from the Mexican Germplasm Bank, which were harvested over three years. Clear differences in chemical composition were detected in fermented and dried samples am ...
DOI:
10.1016/j.foodcont.2021.108347

4. Epicatechin treatment generates resilience to chronic mild stress-induced depression in a murine model

Author:
Martínez-Damas, Mirna Guadalupe; Genis-Mendoza, Alma Delia; Pérez-de la Cruz, Verónica; Canela-Tellez, Gabriel Daniel; Jiménez-Estrada, Ismael; Sanchez, José Humberto Nicolini; Ramos-Chávez, Lucio Antonio; García, Silvia; Ramírez-Ramírez, Magally; Coral-Vázquez, Ramón Mauricio
Source:
Physiology & behavior 2021 pp. 113466
ISSN:
0031-9384
Subject:
epicatechin,   etc   ; adjuvants; animal models; anxiety; behavior; chocolate; exercise; kynurenine; males; metabolism; mice; sucrose; transaminases;     Show all 13 Subjects
Abstract:
... Several studies have proposed that cocoa products-enriched in flavonoids reduce anxiety and depressive symptoms. (-)–Epicatechin (Epi), a flavonoid present in high concentration in cocoa, has been associated with many dark chocolate effects and has been postulated as an exercise mimetic. Physical exercise is used as an adjuvant treatment for many depressive patients. This study aimed to evaluate t ...
DOI:
10.1016/j.physbeh.2021.113466

5. Relationship between bioactive compounds and sensory properties of dark chocolate produced from Brazilian hybrid cocoa

Author:
das Virgens, Ivia Araújo; Pires, Tassia Cavalcante; de Santana, Ligia Regina Radomille; Soares, Sérgio Eduardo; Maciel, Leonardo Fonseca; Ferreira, Adriana Cristina Reis; Biasoto, Aline Camarão Telles; Bispo, Eliete da Silva
Source:
International journal of food science & technology 2021 v.56 no.4 pp. 1905-1917
ISSN:
0950-5423
Subject:
epicatechin,   etc   ; astringency; bitterness; caffeine; catechin; chocolate; food science; hybrids; sensory evaluation; taste; technology; theobromine; Brazil;     Show all 13 Subjects
Abstract:
... This work evaluated the influence of bioactive compounds on the sensory profile and acceptability of dark chocolate produced from Brazilian hybrid cocoa. The results showed that higher contents of catechin, epicatechin, caffeine, total phenolic compounds and flavonoids contributed to higher intensity of bitterness, cocoa flavour, acid taste, and astringency, and negatively affected the acceptance ...
DOI:
10.1111/ijfs.14820

6. Solubility of catechin and epicatechin from Arachis Hypogea skins wastes by using supercritical carbon dioxide-ethanol and its optimization

Author:
Putra, Nicky Rahmana; Rizkiyah, Dwila Nur; Zaini, Ahmad Syami; Machmudah, Siti; Yunus, Mohd Azizi Che
Source:
Journal of food measurement & characterization 2021 v.15 no.2 pp. 2031-2038
ISSN:
2193-4126
Subject:
epicatechin,   etc   ; Arachis hypogaea; carbon; catechin; ethanol; measurement; peanuts; response surface methodology; solubility; supercritical fluid extraction; temperature;     Show all 11 Subjects
Abstract:
... This research aims to optimize a supercritical carbon dioxide extraction assisted by co-solvent ethanol for the recovery of catechin and epicatechin from peanut (Arachis Hypogea) skin. The second objective was to determine the solubility of catechin and epicatechin by semi-empirical models. The operating conditions were: pressure of 10 to 30 MPa; temperature of 313 to 343 K; and ethanol rate of 0. ...
DOI:
10.1007/s11694-020-00797-3

7. Phenolic Compounds from Leaves and Flowers of Hibiscus roseus: Potential Skin Cosmetic Applications of an Under-Investigated Species

Author:
dos Santos Nascimento, Luana Beatriz; Gori, Antonella; Raffaelli, Andrea; Ferrini, Francesco; Brunetti, Cecilia
Source:
Plants 2021 v.10 no.3
ISSN:
2223-7747
Subject:
epicatechin,   etc   ; Hibiscus; antioxidant activity; antioxidants; catechin; cosmetics; kaempferol; phloridzin; polyphenols; quercetin; Italy;     Show all 11 Subjects
Abstract:
... The use of plant extracts in skin-care cosmetics is a modern trend due to their richness in polyphenols that act as anti-aging molecules. Hibiscus roseus is a perennial species naturalized in Italy, with beautiful soft pink flowers; its phenolic composition and biological activities have not been studied yet. The aim of this study was to characterize and quantify the phenolics and to evaluate the ...
DOI:
10.3390/plants10030522

8. A novel antioxidant source: evaluation of in vitro bioaccessibility, antioxidant activity and polyphenol profile of phenolic extract from black radish peel wastes (Raphanus sativus L. var. niger) during simulated gastrointestinal digestion

Author:
Yücetepe, Aysun; Altin, Gokce; Özçelik, Beraat
Source:
International journal of food science & technology 2021 v.56 no.3 pp. 1376-1384
ISSN:
0950-5423
Subject:
epicatechin,   etc   ; antioxidant activity; antioxidants; bioavailability; ferulic acid; food additives; in vitro digestion; polyphenols; radishes; technology; wastes;     Show all 11 Subjects
Abstract:
... The aim of this study was to evaluate the potency of polyphenolic extract from black radish (Raphanus sativus L. var. niger) root peel waste (PEBRRP) as an antioxidant food additive. PEBRRP was found a powerful antioxidant extract, in which had 172.9 ± 11.5, 462.72 ± 3.05, and 796.51 ± 10.4 mg TE per g dw of total antioxidant capacity (TAC) by CUPRAC, DPPH, and FRAP assays, respectively. The total ...
DOI:
10.1111/ijfs.14494

9. Study of antioxidant activity and phenolic compounds of extracts obtained from different craft beer by-products

Author:
Petrón, M.J.; Andrés, A.I.; Esteban, G.; Timón, M.L.
Source:
Journal of cereal science 2021 v.98 pp. 103162
ISSN:
0733-5210
Subject:
epicatechin,   etc   ; acetates; antioxidant activity; beers; brewing; extracts; gallic acid; lees; malt; sampling; sinapic acid; spent grains;     Show all 12 Subjects
Abstract:
... This work deals with the study of the in vitro antioxidant potential of aqueous extracts obtained from brewer's spent grain (BSG) and lees (BL) from four brewing craft beers. The effect of type of malt (base malts with different percentage of roasted malt (BSG1: 0%, BSG2: 7,2%, BSG3: 11,8% and BSG4: 16%) and hop added during brewing (BL1-3: boil hopping, BL4: boil and dry hopping)) on the antioxid ...
DOI:
10.1016/j.jcs.2021.103162

10. Separation of epigallocatechin gallate and epicatechin gallate from tea polyphenols by macroporous resin and crystallization

Author:
Wang, Li; Huang, Xin; Jing, Huijuan; Ye, Xin; Jiang, Chao; Shao, Jiajia; Ma, Chaoyang; Wang, Hongxin
Source:
Analytical methods 2021 v.13 no.6 pp. 832-842
ISSN:
1759-9679
Subject:
epicatechin,   etc   ; adsorption; chromatography; cost effectiveness; crystallization; desorption; epigallocatechin gallate; ethanol; green tea; medicine; polyphenols; porous media;     Show all 12 Subjects
Abstract:
... Epigallocatechin gallate (EGCG) and epicatechin gallate (ECG) are the most abundant ester catechins of green tea polyphenols (GTPs) with numerous potential bioactivities, which have wide application prospects in the fields of medicine and functional foods. In this study, a new method using macroporous resin and crystallization was established to separate and purify EGCG and ECG. Two resins with hi ...
DOI:
10.1039/d0ay02118k

11. New compounds from the aerial parts of Calligonum mongolicum

Author:
Buyankhishig, Buyanmandakh; Murata, Toshihiro; Odonbayar, Batsukh; Batkhuu, Javzan; Sasaki, Kenroh
Source:
Phytochemistry letters 2021 v.41 pp. 147-151
ISSN:
1874-3900
Subject:
epicatechin,   etc   ; Calligonum; aerial parts; catechin; chemical structure; enzyme inhibition; monophenol monooxygenase; reproducibility; sampling; spectroscopy; stereochemistry;     Show all 11 Subjects
Abstract:
... Previously undescribed compounds, (R)-4-(4-hydroxyphenyl)-2-butanol 2-O-(6-O-galloyl)-β-D-glucopyranoside (1) and (E)-5-(4-hydroxyphenyl)pent-2-enoic acid (2), together with 20 known compounds (3-22) were isolated from the aerial parts of Calligonum mongolicum. Compound 3 was obtained from a natural source for the first time, and all of the compounds (1-22) were reported for the first time in this ...
DOI:
10.1016/j.phytol.2020.12.002

12. Catechins in green tea powder (matcha) are heat-stable scavengers of acrolein, a lipid peroxide-derived reactive carbonyl species

Author:
Sugimoto, Koichi; Matsuoka, Yasumasa; Sakai, Kyoko; Fujiya, Norika; Fujii, Hiroyuki; Mano, Jun'ichi
Source:
Food chemistry 2021 v.355 pp. 129403
ISSN:
0308-8146
Subject:
epicatechin,   etc   ; acrolein; aqueous solutions; cakes; catechin; dough; epigallocatechin gallate; food additives; food chemistry; green tea; heat stability; lipids;     Show all 12 Subjects
Abstract:
... Lipid peroxidation-derived reactive carbonyl species (RCS) such as acrolein and 4-hydroxynonenal pose health risks. We characterized the RCS-scavenging reactions of tea catechins in an aqueous solution and in baked cake. Acrolein’s reaction with each of the major tea catechins (epicatechin, epigallocatechin, epicatechin gallate, and epigallocatechin gallate) resulted in the formation of mono-, di- ...
DOI:
10.1016/j.foodchem.2021.129403

13. Untargeted metabolomics coupled with chemometrics approach for Xinyang Maojian green tea with cultivar, elevation and processing variations

Author:
Wang, Huijun; Cao, Xueli; Yuan, Zhengfang; Guo, Guiyi
Source:
Food chemistry 2021 v.352 pp. 129359
ISSN:
0308-8146
Subject:
epicatechin,   etc   ; altitude; chemometrics; correlation; cultivars; epigallocatechin gallate; food chemistry; green tea; liquids; mass spectrometry; metabolites; metabolomics; theanine; umami;     Show all 14 Subjects
Abstract:
... The quality and flavor of green tea can be affected by various factors, which are closely related to the metabolite composition of tea. In this study, 66 Xinyang Maojian tea (XYMJ) samples produced by four cultivars, grown in different elevations and manufactured by different processing methods were analyzed by untargeted ultra-performance liquid chromatography-quadrupole time-of-flight mass spect ...
DOI:
10.1016/j.foodchem.2021.129359

14. Phenolic composition, antioxidant capacity and α-glucosidase inhibitory activity of raw and boiled Chilean Araucaria araucana kernels

Author:
Schmeda-Hirschmann, Guillermo; Antileo-Laurie, Javier; Theoduloz, Cristina; Jiménez-Aspee, Felipe; Avila, Felipe; Burgos-Edwards, Alberto; Olate-Olave, Verónica
Source:
Food chemistry 2021 v.350 pp. 129241
ISSN:
0308-8146
Subject:
epicatechin,   etc   ; Araucaria araucana; antioxidant activity; catechin; digestion; food chemistry; lipid peroxidation; models; oxidative stress; phenolic compounds; traditional foods; Argentina; Chile;     Show all 13 Subjects
Abstract:
... The Araucaria araucana kernels are a traditional food in southern Chile and Argentina. The aim of this work was to determine the composition of the phenolic-enriched extracts (PEEs) of the boiled kernels as well as their antioxidant capacity, inhibitory activity on metabolic syndrome-associated enzymes and effect on postprandial oxidative stress in a simulated gastric digestion model. The PEEs com ...
DOI:
10.1016/j.foodchem.2021.129241

15. Formation of A-type anthocyanin-epicatechin dimers by model reactions of anthocyanin extracts and epicatechin

Author:
Li, Wei; Yu, Jiahao; Zhang, Jian; Zhang, Lianfu
Source:
Lebensmittel-Wissenschaft + [i.e. und] Technologie 2021 v.146 pp. 111475
ISSN:
0023-6438
Subject:
epicatechin,   etc   ; Aronia melanocarpa; Lewis bases; Lonicera caerulea; Lycium ruthenicum; anthocyanins; cranberries; heat treatment; pH; proanthocyanidins; urinary tract;     Show all 11 Subjects
Abstract:
... A-type proanthocyanidins (PACs) with health benefits such as prevention of urinary-tract infections are less common in food. Anthocyanins can directly condense with epicatechins to give rise to A-type anthocyanin-epicatechin dimers linked by C4–C8 and C2–O–C7 bonds, analogues of A-type PACs. Cyanidin-3-glucoside, cyanidin-3-galactoside, and petunidin-3-rutinoside-(p-coumaroyl)-5-glucose are the ma ...
DOI:
10.1016/j.lwt.2021.111475

16. Isolation of Lactiplantibacillus sp. from Korean salted and fermented seafoods for effective fermentation of strawberry leaf extract: enhanced anti-inflammatory activity

Author:
Lee, Se-Won; Choi, Ui-Lim; Lim, Jeong-Muk; Lee, Seong-Hyeon; Mohan, Harshavardhan; Seralathan, Kamala-Kannan; Park, Yool-Jin; Oh, Byung-Taek
Source:
3 Biotech 2021 v.11 no.6 pp. 268
ISSN:
2190-572X
Subject:
epicatechin,   etc   ; anti-inflammatory activity; antioxidants; catechin; fermentation; interleukin-6; leaf extracts; nitric oxide; polyphenols; strawberries; toxicity testing; Korean Peninsula;     Show all 12 Subjects
Abstract:
... Berries are rich in bioactive phytochemicals and phenolic compounds. In the present study, strawberry leaves obtained from Nangsan-myeon, Jeollabuk-do, Korea in 2019 were fermented using Lactiplantibacillus plantarum B1-4 and studied for antioxidant and anti-inflammatory properties. Comparative testing of active ingredients in the raw and fermented extract showed an increase in total polyphenol co ...
DOI:
10.1007/s13205-021-02753-4

17. Characterization of epicathechin contents in the Ziziphus spina-christi L. root extracts using LC-MS analyses and their insecticidal potential

Author:
Elaloui, Meriem; Hamdi, Soumaya Haouel; Ghazghazi, Hanen; Nasr, Rania Ben; Bouslih, Emna; Ammari, Youssef; Mediouni, Jouda; Laamouri, Abdelwahed
Source:
Plant biosystems 2021 v.155 no.4 pp. 685-690
ISSN:
1724-5575
Subject:
epicatechin,   etc   ; 2,2-diphenyl-1-picrylhydrazyl; Lasioderma serricorne; Ziziphus spina-christi; biopesticides; ethanol; insecticidal properties; liquid chromatography; mass spectrometry; solvents; toxicity;     Show all 11 Subjects
Abstract:
... The goal of this study was to assess the phenolic composition of the various Ziziphus spina-christi root extracts (aqueous, methanlic, ethanolic and acetonic). The highest amounts of total phenols (60.47 mg GEA/g DW) flavonoids (12.04 mg QE/g DW) and tannin (23.98 mg CE/g DW) were showed in the ethanol solvent. Epicatechin contents were detected, using Liquid Chromatography-mass spectrometry, at l ...
DOI:
10.1080/11263504.2020.1779837

18. Isolation and identification of putative precursors of the volatile sulfur compounds and their inhibition methods in heat-sterilized melon juices

Author:
Pan, Xin; Zhang, Wentao; Lao, Fei; Mi, Ruifang; Liao, Xiaojun; Luo, Dongsheng; Wu, Jihong
Source:
Food chemistry 2021 v.343 pp. 128459
ISSN:
0308-8146
Subject:
epicatechin,   etc   ; Lewis bases; degradation; dimethyl disulfide; dimethyl sulfide; food chemistry; juices; melons; methionine; off flavors; pH; separation; sulfur;     Show all 13 Subjects
Abstract:
... Volatile sulfur compounds, such as dimethyl sulfide, dimethyl disulfide and dimethyl trisulfide, cause the off-flavor in heat-sterilized juices and limit the commercial production of juices. In this study, we investigated the precursors for these volatile sulfur compounds and analyzed the potential inhibition methods. Upon separation of melon juice components using resin column, the dimethyl sulfi ...
DOI:
10.1016/j.foodchem.2020.128459

19. Influence of genetic background, growth latitude and bagging treatment on phenolic compounds in fruits of commercial cultivars and wild types of apples (Malus sp.)

Author:
Li, Yajing; Sun, Hongxia; Li, Jindong; Qin, Shu; Niu, Zimian; Qiao, Xiongwu; Yang, Baoru
Source:
European food research & technology 2021 v.247 no.5 pp. 1149-1165
ISSN:
1438-2377
Subject:
epicatechin,   etc   ; Malus domestica; altitude; apples; chlorogenic acid; cultivars; food research; fruits; genetic background; glycosides; latitude; procyanidins; quercetin; technology;     Show all 14 Subjects
Abstract:
... Phenolic compounds in apples 17 cultivars (Malus domestica Borkh.) and 3 wild forms (Malus sp.) were analyzed to study the impact of genetic background, growth site, and fruit bagging. The impact of altitude was studied in nine cultivars by analyzing fruits collected from orchards at three altitudes. Procyanidin B2 (71–628 μg/g fresh weight), (−)-epicatechin (35–357 μg/g), and chlorogenic acid (28 ...
DOI:
10.1007/s00217-021-03695-0

20. Phenolic profiles, bioaccessibility and antioxidant activity of plum (Prunus Salicina Lindl)

Author:
Yu, Jiawen; Li, Wu; You, Bangyan; Yang, Shiying; Xian, Wenyan; Deng, Yu; Huang, Wei; Yang, Ruili
Source:
Food research international 2021 v.143 pp. 110300
ISSN:
0963-9969
Subject:
epicatechin,   etc   ; Prunus salicina; antioxidant activity; antioxidants; bioavailability; catechin; correlation; digestion; food research; gastrointestinal system; human health; plums; procyanidins;     Show all 13 Subjects
Abstract:
... Plum (Prunus Salicina Lindl) is a rich source of phenolic compounds. However, the bound phenolics and its bioaccessibility and antioxidant activity remain unclear. Hence, the purpose of this study was to determine: 1) phenolic profiles of plum, including both free and bound phenolic fractions, 2) bioaccessibility of phenolic compounds in plum during simulated gastrointestinal digestions, 3) their ...
DOI:
10.1016/j.foodres.2021.110300