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1. Discrimination of Pd-species by an ultra-fast, long wavelength and biocompatible fluorescent sensor: Its on-site kit assay, drug, and cancer/epithelial cell studies

Author:
Serkan Erdemir; Sait Malkondu; Mehmet Oguz
Source:
Talanta 2023 v.252 pp. 123847
ISSN:
0039-9140
Subject:
epithelial cells,   etc   ; biocompatibility; colorimetry; detection limit; drugs; fluorescence; fluorescent dyes; oxidation; palladium; soil; water pollution; wavelengths;     Show all 12 Subjects
Abstract:
... Extensive use of palladium in many catalysts and catalytic converters causes a high degree of pollution of water and soil resources. Therefore, there is an urgent need to develop rapid and sensitive palladium probes. Herein, a novel “turn-on” near-infrared (NIR) fluorescence and colorimetric probe for Pd has been designed on the basis of the deallylation of the probe, followed by the release of NI ...
DOI:
10.1016/j.talanta.2022.123847

2. Porphyra haitanensis polysaccharide (PH) attenuates cell hyperplasia via remodeling the cross-talk between Hippo/YAP and mTOR pathways

Author:
Chong Wang; Wanglei Lin; Zhihua Sun; Yiming Sun; Yanbo Wang; Linglin Fu
Source:
Food science and human wellness 2023 v.12 no.2 pp. 424-430
ISSN:
2213-4530
Subject:
epithelial cells,   etc   ; Fourier transform infrared spectroscopy; Porphyra; cell proliferation; food science; humans; hyperplasia; intestines; models; polysaccharides; rapamycin;     Show all 11 Subjects
Abstract:
... Porphyra polysaccharide is a special kind of nutrient showing multiple physiological functions including regulating cell proliferation, but the detailed mechanisms are not fully revealed, impairing its further development and applications. This work was to purify and characterize the Porphyra haitanensis polysaccharide (PH), investigate its physiological function, and demonstrate the underlying me ...
DOI:
10.1016/j.fshw.2022.07.044

3. Topical systems for the controlled release of antineoplastic Drugs: Oxidized Alginate-Gelatin Hydrogel/Unilamellar vesicles

Author:
Soledad Stagnoli; Cintia Garro; Ozlem Ertekin; Susanne Heid; Stefan Seyferth; Gastón Soria; N. Mariano Correa; Aldo Leal-Egaña; Aldo R. Boccaccini
Source:
Journal of colloid and interface science 2023 v.629 pp. 1066-1080
ISSN:
0021-9797
Subject:
epithelial cells,   etc   ; adenocarcinoma; biocompatibility; curcumin; cytotoxicity; drug carriers; drugs; fibroblasts; freeze drying; humans; hydrogels; melanoma; oxidation; rats; topical application; water solubility;     Show all 16 Subjects
Abstract:
... The efficacy of chemotherapeutic procedures relies on delivering proper concentrations of anti-cancer drugs in the tumor surroundings, so as to prevent potential side effects on healthy tissues. Novel drug carrier platforms should not just be able to deliver anticancer molecules, but also allow for adjustements in the way these drugs are administered to the patients. We developed a system for deli ...
DOI:
10.1016/j.jcis.2022.08.163

4. When is a neuron like an epithelial cell

Author:
Maxwell G. Heiman
Source:
Developmental biology 2022 v.489 pp. 161-164
ISSN:
0012-1606
Subject:
epithelial cells,   etc   ; epithelium; olfactory receptors;     Show all 3 Subjects
Abstract:
... Neurons and epithelia are viewed as fundamentally different cell types, yet some sensory neurons exhibit hallmarks of epithelial cells. For example, they use tight junctions to form a diffusion barrier continuous with the skin or other epithelia and they exhibit bona fide apical-basal polarity, with an outward-facing apical surface that is biochemically and functionally distinct from their inward- ...
DOI:
10.1016/j.ydbio.2022.06.012

5. Effect of the gene silencing of phosphorus transporters on phosphorus absorption across primary cultured duodenal epithelial cell monolayers of chick embryos

Author:
Ting-ting LI; Na LU; Yu-xin SHAO; Li-yang ZHANG; Lin LU; Zong-ping LIU; Xu-gang LUO; Xiu-dong LIAO
Source:
Journal of integrative agriculture 2022 v.21 no.7 pp. 2076-2085
ISSN:
2095-3119
Subject:
epithelial cells,   etc   ; absorption; agriculture; chicks; epithelium; genes; phosphorus; symporters;     Show all 8 Subjects
Abstract:
... The aim of the study was to investigate whether phosphorus (P) transporters, type IIb sodium-dependent phosphate cotransporter (NaP-IIb) and inorganic phosphate transporter 2 (PiT2), were directly involved in P absorption across primary cultured duodenal epithelial cell monolayers of chick embryos. The siRNAs against NaP-IIb or PiT2 were designed, synthesized and transfected into primary cultured ...
DOI:
10.1016/S2095-3119(21)63771-1

6. Porcine and Chicken Intestinal Epithelial Cell Models for Screening Phytogenic Feed Additives—Chances and Limitations in Use as Alternatives to Feeding Trials

Author:
Hannah Marks; Łukasz Grześkowiak; Beatriz Martinez-Vallespin; Heiko Dietz; Jürgen Zentek
Source:
Microorganisms 2022 v.10 no.3 pp. -
ISSN:
2076-2607
Subject:
epithelial cells,   etc   ; cell lines; chickens; coculture; farms; models; organoids; swine;     Show all 8 Subjects
Abstract:
... Numerous bioactive plant additives have shown various positive effects in pigs and chickens. The demand for feed additives of natural origin has increased rapidly in recent years to support the health of farm animals and thus minimize the need for antibiotics and other drugs. Although only in vivo experiments can fully represent their effect on the organism, the establishment of reliable in vitro ...
DOI:
10.3390/microorganisms10030629

7. Asymmetric organelle positioning during epithelial polarization of C. elegans intestinal cells

Author:
James N. Brandt; Laura Voss; Fiona M. Rambo; Katelyn Nicholson; Jackson R. Thein; Lydia Fairchild; Laurence Seabrook; Danielia Lewis; Lali Guevara-Hernandez; Matthew L. White; Luca Sax; Victoria Eichten; Logan Harper; Greg J. Hermann
Source:
Developmental biology 2022 v.481 pp. 75-94
ISSN:
0012-1606
Subject:
epithelial cells,   etc   ; adenosinetriphosphatase; asymmetry; cortex; endosomes; epithelium; intestines; lipids; lysosomes;     Show all 9 Subjects
Abstract:
... While the epithelial cell cortex displays profound asymmetries in protein distribution and morphology along the apico-basal axis, the extent to which the cytoplasm is similarly polarized within epithelial cells remains relatively unexplored. We show that cytoplasmic organelles within C. elegans embryonic intestinal cells develop extensive apico-basal polarity at the time they establish cortical as ...
DOI:
10.1016/j.ydbio.2021.09.007

8. Streptococcus pyogenes NAD+-Glycohydrolase Reduces Skeletal Muscle βNAD+ Levels Independently of Streptolysin O

Author:
Eric R. McIndoo; Emily Price; Cheri L. Lamb; Christopher S. Dayton; Clifford R. Bayer; Dennis L. Stevens; Amy E. Bryant; Sarah E. Hobdey
Source:
Microorganisms 2022 v.10 no.7 pp. -
ISSN:
2076-2607
Subject:
epithelial cells,   etc   ; Streptococcus pyogenes; fascia; humans; muscles; necrosis; skeletal muscle; streptolysin;     Show all 8 Subjects
Abstract:
... Necrotizing soft tissue infections caused by Streptococcus pyogenes (group A streptococcus [GAS]) are characterized by rapid and extensive necrosis of fascia and muscle. Molecular epidemiological studies have demonstrated a positive correlation between GAS isolates that cause invasive infections and the production of S. pyogenes NAD+-glycohydrolase (SPN), an NADase secreted by GAS, but the effect ...
DOI:
10.3390/microorganisms10071476

9. Dynamic synthesis and transport of fluorescent substances from moulting scorpions

Author:
Songryong Li; Cholman Kim; Shaozhi Zong; Yuqing Liu; Jongguk Kang; Cholmin Pak; Zhijian Cao; Yingliang Wu
Source:
Journal of photochemistry and photobiology 2022 v.234 pp. 112511
ISSN:
1011-1344
Subject:
epithelial cells,   etc   ; Scorpiones; abdomen; ecdysis; evolution; exoskeleton; fluorescence; photobiology; photochemistry; ultraviolet radiation;     Show all 10 Subjects
Abstract:
... Scorpion fluorescence under ultraviolet light is a well-known phenomenon, and its change is also a known biological feature during the scorpion moulting process. However, the synthesis and transport of fluorescent substances during the moulting stage remain unclear. In this study, in-depth investigations on the global fluorescence changes from the exoskeleton, fluorescence layer, coelomic fluid, a ...
DOI:
10.1016/j.jphotobiol.2022.112511

10. Inhibition of immunoproteasome attenuates NLRP3 inflammasome formation in tumor necrosis factor α-stimulated intestinal epithelial cell

Author:
Boran Yoon; Yewon Yun; Kyung Bo Kim; Dong-Eun Kim
Source:
Biochemical and biophysical research communications 2022 v.624 pp. 157-163
ISSN:
0006-291X
Subject:
epithelial cells,   etc   ; caspase-1; inflammasomes; inflammation; inflammatory bowel disease; permeability; research; secretion; therapeutics;     Show all 9 Subjects
Abstract:
... Excessive release of inflammatory cytokines has been considered as a major cause of chronic inflammation, resulting in intestinal barrier disruption that leads to inflammatory bowel disease (IBD). Tumor necrosis factor α (TNFα) is one of the well-known inflammatory cytokines that activates formation of NLRP3 inflammasome, thus resulting in excessive secretion of inflammatory cytokines causing IBD. ...
DOI:
10.1016/j.bbrc.2022.07.120

11. Zebrafish corneal wound healing: from abrasion to wound closure imaging analysis

Author:
Ikkala Kaisa; Raatikainen Sini; Michon Frederic
Source:
Journal of visualized experiments 2022 no.181 pp. e63605
ISSN:
1940-087X
Subject:
epithelial cells,   etc   ; Danio rerio; cornea; drugs; epithelium; fish; group behavior; models; stress response;     Show all 9 Subjects
Abstract:
... As the transparent surface of the eye, the cornea is instrumental for clear sight. Due to its location, this tissue is prone to environmental insults. Indeed, the eye injuries most frequently encountered clinically are those to the cornea. While corneal wound healing has been extensively studied in small mammals (i.e., mice, rats, and rabbits), corneal physiology studies have neglected other speci ...
DOI:
10.3791/63605

12. Developmental regulation of epithelial cell cuboidal-to-squamous transition in Drosophila follicle cells

Author:
Dongyu Jia; Allison Jevitt; Yi-Chun Huang; Belen Ramos; Wu-Min Deng
Source:
Developmental biology 2022 v.491 pp. 113-125
ISSN:
0012-1606
Subject:
epithelial cells,   etc   ; Drosophila; RNA; ecdysone; eggs; epithelium; gene expression; oogenesis; organogenesis; transcription factors;     Show all 10 Subjects
Abstract:
... Epithelial cells form continuous membranous structures for organ formation, and these cells are classified into three major morphological categories: cuboidal, columnar, and squamous. It is crucial that cells transition between these shapes during the morphogenetic events of organogenesis, yet this process remains poorly understood. All three epithelial cell shapes can be found in the follicular e ...
DOI:
10.1016/j.ydbio.2022.09.001

13. Alternative translation and retrotranslocation of cytosolic C3 that detects cytoinvasive bacteria

Author:
Mariann Kremlitzka; Lucie Colineau; Alicja A. Nowacka; Frida C. Mohlin; Katarzyna Wozniak; Anna M. Blom; Ben C. King
Source:
Cellular and molecular life sciences 2022 v.79 no.6 pp. 291
ISSN:
1420-682X
Subject:
epithelial cells,   etc   ; Staphylococcus aureus; blood serum; complement; cytosol; endoplasmic reticulum; glycosylation; signal peptide; vacuoles;     Show all 9 Subjects
Abstract:
... Complement C3 was originally regarded as a serum effector protein, although recent data has emerged suggesting that intracellular C3 can also regulate basic cellular processes. Despite the growing interest in intracellular C3 functions, the mechanism behind its generation has not been demonstrated. In this study we show that C3 can be expressed from an alternative translational start site, resulti ...
DOI:
10.1007/s00018-022-04308-z

14. Self‐organization of apical membrane protein sorting in epithelial cells

Author:
Daniel S. Levic; Michel Bagnat
Source:
FEBS journal 2022 v.289 no.3 pp. 659-670
ISSN:
1742-464X
Subject:
epithelial cells,   etc   ; asymmetry; cell physiology; epithelium; homeostasis; membrane proteins; oligomerization; pH; plasma membrane; separation;     Show all 10 Subjects
Abstract:
... Polarized epithelial cells are characterized by the asymmetric distribution of proteins between apical and basolateral domains of the plasma membrane. This asymmetry is highly conserved and is fundamental to epithelial cell physiology, development, and homeostasis. How proteins are segregated for apical or basolateral delivery, a process known as sorting, has been the subject of considerable inves ...
DOI:
10.1111/febs.15882

15. Amphiphilic silicones to mitigate lens epithelial cell growth on intraocular lenses

Author:
Alec C. Marmo; J. Jesus Rodriguez Cruz; Jackson H. Pickett; Lucas R. Lott; Dustin S. Theibert; Heather L. Chandler; Melissa A. Grunlan
Source:
Journal of materials chemistry B 2022 v.10 no.16 pp. 3064-3072
ISSN:
2050-7518
Subject:
epithelial cells,   etc   ; actin; air; biphenyl; cell growth; crosslinking; hydrophilicity; muscles; patients; silicone; surfactants; transmittance;     Show all 12 Subjects
Abstract:
... Silicone intraocular lenses (IOLs) that resist lens epithelial cell (LEC) growth would greatly improve patient outcomes. Herein, amphiphilic surface modifying additives (SMAs) were incorporated into an IOL-type diphenyl silicone to reduce LEC growth without compromising opto-mechanical properties. The SMAs were poly(ethylene oxide)-silane amphiphiles (PEO-SAs) [H-Si-ODMSₘ-block-PEO₈-OCH₃], compris ...
DOI:
10.1039/d2tb00213b

16. Genome-nanosurface interaction of titania nanotube arrays: evaluation of telomere, telomerase and NF-κB activities on an epithelial cell model

Author:
Rabiatul Basria S. M. N. Mydin; Srimala Sreekantan; Darius Widera; Khairul Arifah Saharudin; Roshasnorlyza Hazan; Mustafa Fadzil Farid Wajidi
Source:
RSC advances 2022 v.12 no.4 pp. 2237-2245
ISSN:
2046-2069
Subject:
epithelial cells,   etc   ; genome; inflammation; models; nanomedicine; nanotubes; phenotype; protein content; telomerase; telomeres; titanium dioxide;     Show all 11 Subjects
Abstract:
... Titanium dioxide nanotube arrays (TNAs) provide a promising platform for medical implants and nanomedicine applications. The present cell–TNA study has provided profound understanding on protection of genome integrity via telomere, telomerase and NF-κB activities using an epithelial cell model. It has been revealed in this study that cell–TNA interaction triggers the telomere shortening activity a ...
DOI:
10.1039/d1ra05325f

17. SMYD3 regulates the abnormal proliferation of non-small-cell lung cancer cells via the H3K4me3/ANO1 axis

Author:
Dian Zhong; Zhiqiang Zhan; Jinqiang Zhang; Yujuan Liu; Zhisheng He
Source:
Journal of biosciences 2022 v.47 no.3 pp. 53
ISSN:
0973-7138
Subject:
epithelial cells,   etc   ; cell proliferation; gene expression; histones; humans; lung neoplasms; lysine; methyltransferases; promoter regions;     Show all 9 Subjects
Abstract:
... Non-small-cell lung cancer (NSCLC) is the most prevalent type of lung cancer. This study evaluated the mechanism of histone methyltransferase SET and MYND domain-containing 3 (SMYD3) in the abnormal proliferation of NSCLC cells. The human bronchial epithelial cell (HBEC) line (16HBE) and NSCLC cell lines (H1299, A549, H460, and H1650) were collected. A549 and H1650 cells were transfected with si-S ...
DOI:
10.1007/s12038-022-00299-y

18. Establishment of bovine 3D enteroid-derived 2D monolayers

Author:
Kate M. Sutton; Brigid Orr; Jayne Hope; Stina R. Jensen; Lonneke Vervelde
Source:
BMC veterinary research 2022 v.53 no.1 pp. 15
ISSN:
1297-9716
Subject:
epithelial cells,   etc   ; cadherins; cattle; cost effectiveness; electrical resistance; epithelium; ileum; models; tight junctions; veterinary medicine;     Show all 10 Subjects
Abstract:
... Three-dimensional (3D) intestinal enteroids are powerful in vitro models for studying intestinal biology. However, due to their closed structure direct access to the apical surface is impeded, limiting high-throughput applications of exogenous compounds and pathogens. In this study, we describe a method for generating confluent 2D enteroids from single-cell suspensions of enzymatically-dissociated ...
DOI:
10.1186/s13567-022-01033-0

19. Drug Discovery Strategies for Inherited Retinal Degenerations

Author:
Arupratan Das; Yoshikazu Imanishi
Source:
Biology 2022 v.11 no.9 pp. -
ISSN:
2079-7737
Subject:
epithelial cells,   etc   ; death; drugs; ganglia; humans; mitophagy; neurons; organoids; phenotype; photoreceptors; phototransduction; retinal degeneration; therapeutics;     Show all 13 Subjects
Abstract:
... Inherited retinal degeneration is a group of blinding disorders afflicting more than 1 in 4000 worldwide. These disorders frequently cause the death of photoreceptor cells or retinal ganglion cells. In a subset of these disorders, photoreceptor cell death is a secondary consequence of retinal pigment epithelial cell dysfunction or degeneration. This manuscript reviews current efforts in identifyin ...
DOI:
10.3390/biology11091338

20. Epithelial-Mesenchymal Plasticity Induced by Discontinuous Exposure to TGFβ1 Promotes Tumour Growth

Author:
Mafalda Santos; Marta Ferreira; Patrícia Oliveira; Nuno Mendes; Ana André; André F. Vieira; Joana B. Nunes; Joana Carvalho; Sara Rocha; Mafalda Azevedo; Daniel Ferreira; Inês Reis; João Vinagre; Joana Paredes; Alireza Heravi-Moussavi; Jorge Lima; Valdemar Máximo; Angela Burleigh; Calvin Roskelley; Fátima Carneiro; David Huntsman; Carla Oliveira
Source:
Biology 2022 v.11 no.7 pp. -
ISSN:
2079-7737
Subject:
epithelial cells,   etc   ; RNA; epithelium; fluorescent antibody technique; models; neoplasm progression; neoplasms; phenotype; plasticity; transcriptomics; xenotransplantation;     Show all 11 Subjects
Abstract:
... Transitions between epithelial and mesenchymal cellular states (EMT/MET) contribute to cancer progression. We hypothesize that EMT followed by MET promotes cell population heterogeneity, favouring tumour growth. We developed an EMT model by on and off exposure of epithelial EpH4 cells (E-cells) to TGFβ1 that mimics phenotypic EMT (M-cells) and MET. We aimed at understanding whether phenotypic MET ...
DOI:
10.3390/biology11071046