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- Author:
- Wei Cao; Xiang Wang; Jiulong Li; Ming Yan; Chong Hyun Chang; Joshua Kim; Jinhong Jiang; Yu-Pei Liao; Shannon Tseng; Sydney Kusumoputro; Candice Lau; Marissa Huang; Pengli Han; Pengju Lu; Tian Xia
- Source:
- Journal of environmental sciences (China) 2022 v.111 pp. 429-441
- ISSN:
- 1001-0742
- Subject:
- epithelium, etc ; air pollution; cathepsin B; collagen; cytotoxicity; fibrosis; humans; inflammasomes; inflammation; lungs; macrophages; particulates; pulmonary fibrosis; China; Show all 14 Subjects
- Abstract:
- ... Airborne fine particulate matter (PM₂.₅) is known to cause respiratory inflammation such as chronic obstructive pulmonary disease and lung fibrosis. NLRP3 inflammasome activation has been implicated in these diseases; however, due to the complexity in PM₂.₅ compositions, it is difficult to differentiate the roles of the components in triggering this pathway. We collected eight real-life PM₂.₅ samp ...
- DOI:
- 10.1016/j.jes.2021.04.021
- https://doi.org/10.1016/j.jes.2021.04.021
- Author:
- Smija M. Kurian; Rafaella G. Naressi; Diogo Manoel; Ann-Sophie Barwich; Bettina Malnic; Luis R. Saraiva
- Source:
- Cell and tissue research 2021 v.383 no.1 pp. 445-456
- ISSN:
- 0302-766X
- Subject:
- antagonists; mammals; mucosa; odor compounds; odors; research
- Abstract:
- ... Noses are extremely sophisticated chemical detectors allowing animals to use scents to interpret and navigate their environments. Odor detection starts with the activation of odorant receptors (ORs), expressed in mature olfactory sensory neurons (OSNs) populating the olfactory mucosa. Different odorants, or different concentrations of the same odorant, activate unique ensembles of ORs. This mechan ...
- DOI:
- 10.1007/s00441-020-03327-1
- https://doi.org/10.1007/s00441-020-03327-1
- Author:
- W. Skronska-Wasek; S. Durlanik; J.P. Garnett; S. Pflanz
- Source:
- Molecular immunology 2021 v.132 pp. 142-149
- ISSN:
- 0161-5890
- Subject:
- epithelium, etc ; Haemophilus influenzae; gene expression regulation; humans; interleukin-6; interleukin-8; liquid-air interface; lungs; macrophages; neutralization; phenotype; secretion; Show all 12 Subjects
- Abstract:
- ... with apical and basolateral epithelial secretions inducing an M1-biased and M2-biased macrophage polarization, respectively. Conversely, in the presence of Nontypeable Haemophilus influenzae (NTHi), apical SN from NTHi-exposed SAEC induced CD36, CD163 and CD300e and supressed CD11c expression suggesting a switch towards an M2-biased macrophage polarization.Analysis of SN from polarized epithelium revealed ...
- DOI:
- 10.1016/j.molimm.2021.01.029
- https://doi.org/10.1016/j.molimm.2021.01.029
- Author:
- Zheng Zhao; Liang Li; Min Cheng; An‐Di Jing; Su‐Ning Liu; Shi‐Ming Zhu; Er‐Xia Du; Sheng Li; Yun‐Xia Luan; Chong‐Hua Ren
- Source:
- Insect science 2021 v.28 no.2 pp. 485-494
- ISSN:
- 1672-9609
- Subject:
- epithelium, etc ; Blattella germanica; Drosophila; central nervous system; chitin synthase; chitinase; ecdysis; embryogenesis; gene targeting; genes; head; hormone receptors; integument; models; transcription factors; Show all 15 Subjects
- Abstract:
- ... The transcription factor grainy head (Grh) functions in the protection of the epithelium against the external environment by generating strongly adhesive layers, and this function is conserved in vertebrates and invertebrates. In Drosophila, the top model for holometabolous insects, Grh is necessary during embryonic development, epidermal differentiation, central nervous system specification ...
- DOI:
- 10.1111/1744-7917.12780
- https://doi.org/10.1111/1744-7917.12780
- Author:
- Wen‐wei Luo; Bin‐Jun Chen; Yan‐mei Wang; Juan‐mei Yang; Xiang Liu; Ya‐sheng Yuan; Xi Lin; Fang‐lu Chi; Ping Chen; Dong‐dong Ren
- Source:
- FEBS journal 2021 v.288 no.3 pp. 1027-1040
- ISSN:
- 1742-464X
- Subject:
- epithelium, etc ; Drosophila; cell polarity; genes; mammals; mutation; nasopharynx; Show all 7 Subjects
- Abstract:
- ... Planar cell polarity (PCP) signalling specifies the orientation of epithelial cells and regulates directional beating of motile cilia of multiciliated epithelial cells. Clinically, defects in cilia function are associated with nasopharyngeal symptoms. The polarity of the nasopharyngeal epithelium is poorly understood. Here, we demonstrated PCP in the nasopharyngeal epithelium. Multiciliated cells ...
- DOI:
- 10.1111/febs.15425
- https://doi.org/10.1111/febs.15425
- Author:
- Yanlong Zhang; Yunjian Yu; Gang Li; Xinge Zhang; Zhongming Wu; Ling Lin
- Source:
- Biomacromolecules 2021 v.22 no.5 pp. 2020-2032
- ISSN:
- 1526-4602
- Subject:
- epithelium, etc ; Staphylococcus; antibiotics; bacteria; bioavailability; boric acid; boron; boronic acids; cell walls; cornea; encapsulation; fluorescence; inflammation; keratitis; mortality; permeability; topical application; vision; Show all 18 Subjects
- Abstract:
- ... A standardized regimen for addressing the adverse effects of bacterial keratitis on vision remains an intractable challenge due to poor epithelial penetration and a short corneal retention time. In this study, a new strategy is proposed to implement the direct transport of antibiotics to bacteria-infected corneas via topical administration of an epithelium-penetrable biodriven nanoplatform ...
- DOI:
- 10.1021/acs.biomac.1c00139
- https://doi.org/10.1021/acs.biomac.1c00139
7. Mycobacterium tuberculosis Infection Up-Regulates Sialyl Lewis X Expression in the Lung Epithelium
- Author:
- Rita Matos; Kaori L. Fonseca; Stefan Mereiter; Ana Raquel Maceiras; Joana Gomes; Cristina Vilaplana; Fátima Gartner; Pedro N. S. Rodrigues; Celso A. Reis; Margarida Saraiva; Ana Magalhães
- Source:
- Microorganisms 2021 v.9 no.1 pp. -
- ISSN:
- 2076-2607
- Subject:
- epithelium, etc ; Mycobacterium tuberculosis; bacteria; biochemical pathways; enzymes; epitopes; genes; glycosylation; homeostasis; infection; lungs; neutrophils; polysaccharides; shape; transcriptomics; tuberculosis; Show all 16 Subjects
- Abstract:
- ... biosynthetic pathway increases the host susceptibility to M. tuberculosis infection, by disrupting the neutrophil homeostasis and enhancing lung pathology. In the present study, we show an increased expression of the sialylated glycan structure Sialyl-Lewis X (SLeX) in the lung epithelium upon M. tuberculosis infection. This increase in SLeX glycan epitope is accompanied by an altered lung tissue ...
- DOI:
- 10.3390/microorganisms9010099
- https://doi.org/10.3390/microorganisms9010099
- Author:
- Yi-Lin Zhang; Wen Liu; Jian-Bang Xu; Qing Sun; Zhuo-Er Qiu; Lei Chen; Jiehong Huang; Yun-Xin Zhu; Wen-Liang Zhou
- Source:
- Molecular and cellular endocrinology 2021 v.526 pp. 111219
- ISSN:
- 0303-7207
- Subject:
- epithelium, etc ; Western blotting; bacterial infections; cystic fibrosis transmembrane conductance regulator; endocrinology; innate immunity; lipopolysaccharides; prostaglandins; rats; secretion; vagina; Show all 11 Subjects
- Abstract:
- ... Prostaglandin E₂ (PGE₂) is a principal lipid mediator mediating various biological processes including immune responses and fluid secretion. As the first line of host defense against infection, vaginal epithelium plays orchestrated roles in vaginal innate immunity. However, the effect of PGE₂ triggered by pro-inflammatory stimuli on vaginal epithelium remains elusive. This study aimed ...
- DOI:
- 10.1016/j.mce.2021.111219
- https://doi.org/10.1016/j.mce.2021.111219
9. Transcriptomic Profiling of Human Pluripotent Stem Cell-derived Retinal Pigment Epithelium over Time
- Author:
- Grace E. Lidgerwood; Anne Senabouth; Casey J.A. Smith-Anttila; Vikkitharan Gnanasambandapillai; Dominik C. Kaczorowski; Daniela Amann-Zalcenstein; Erica L. Fletcher; Shalin H. Naik; Alex W. Hewitt; Joseph E. Powell; Alice Pébay
- Source:
- Genomics, proteomics & bioinformatics 2021 v.19 no.2 pp. 223-242
- ISSN:
- 1672-0229
- Subject:
- epithelium, etc ; antioxidants; bioinformatics; embryonic stem cells; gene ontology; genomics; humans; oxidative stress; patients; proteomics; sequence analysis; transcription (genetics); transcriptomics; Show all 13 Subjects
- Abstract:
- ... Human pluripotent stem cell (hPSC)-derived progenies are immature versions of cells, presenting a potential limitation to the accurate modelling of diseases associated with maturity or age. Hence, it is important to characterise how closely cells used in culture resemble their native counterparts. In order to select appropriate time points of retinal pigment epithelium (RPE) cultures that reflect ...
- DOI:
- 10.1016/j.gpb.2020.08.002
- https://doi.org/10.1016/j.gpb.2020.08.002
- Author:
- Masamichi Kurohmaru; Toshiyasu Matsui; Hitomi Igarashi; Shosaku Hattori; Yoshihiro Hayashi
- Source:
- Anatomia, histologia, embryologia 2021 v.50 no.2 pp. 417-421
- ISSN:
- 0340-2096
- Subject:
- seminiferous epithelium, etc ; Trimeresurus flavoviridis; actin; adults; immune response; light microscopy; snakes; spermatids; spermatocytes; spermatogenesis; spermatogonia; testicular development; Show all 12 Subjects
- Abstract:
- ... The postnatal testicular development and actin distribution in the seminiferous epithelium were examined by light microscopy, using the testes of the Habu (Trimeresurus flavoviridis; snake) from 0‐year‐old to 3‐year‐old. At 0‐year‐old (about 1 month after birth), the testis was quite small in size, and the seminiferous epithelium was composed of only Sertoli cells and large spermatogonia. Actin ...
- DOI:
- 10.1111/ahe.12628
- https://doi.org/10.1111/ahe.12628
11. Tucumã (Astrocaryum aculeatum) Prevents Oxidative and DNA Damage to Retinal Pigment Epithelium Cells
- Author:
- Beatriz da Silva Rosa Bonadiman; Cláudia Chaves; Charles Elias Assmann; Grazielle Castagna Cezimbra Weis; Audrei de Oliveira Alves; Amanda Leitão Gindri; Cláudio Chaves; Ivana Beatrice Mânica da Cruz; Ariane Zamoner; Margarete Dulce Bagatini
- Source:
- Journal of medicinal food 2021 v.24 no.10 pp. 1050-1057
- ISSN:
- 1557-7600
- Subject:
- epithelium, etc ; Astrocaryum aculeatum; DNA; DNA damage; antioxidant activity; apoptosis; caffeic acid; catechin; cell viability; cytotoxicity; eyes; flow cytometry; fruits; functional foods; gallic acid; human health; longevity; luteolin; macular degeneration; mass spectrometry; models; morbidity; mutagens; necrosis; oxidants; oxidative stress; quercetin; rutin; superoxide anion; traditional medicine; ultra-performance liquid chromatography; vision; Amazonia; Show all 33 Subjects
- Abstract:
- ... by riverside communities in traditional medicine to treat a number of ailments. These communities have recently shown to have increased longevity and reduced prevalence of age-related morbidity. Thus, the aim of this research was to chemically characterize and analyze the in vitro antioxidant effect and molecular damage prevention of the Tucumã ethanolic extract in retinal pigment epithelium (RPE) cells ...
- DOI:
- 10.1089/jmf.2020.0171
- https://doi.org/10.1089/jmf.2020.0171
12. Serotonin modulates Campylobacter jejuni physiology and invitro interaction with the gut epithelium
- Author:
- Joshua M. Lyte; Sandip Shrestha; Basanta R. Wagle; Rohana Liyanage; Diego A. Martinez; Annie M. Donoghue; Karrie M. Daniels; Mark Lyte
- Source:
- Poultry science 2021 v.100 no.3 pp. 100944
- ISSN:
- 0032-5791
- Subject:
- Campylobacter jejuni; adhesion; broiler chickens; cecum; cell lines; colon; epithelial cells; geographical distribution; host-pathogen relationships; ileum; liquid chromatography; mucosa; norepinephrine; pathogenicity; physiology; proteome; serosa; serotonin; tandem mass spectrometry
- Abstract:
- ... the physiology of C. jejuni and its interaction with the host gut epithelium. Considering the avian gut produces serotonin and serves as a major reservoir of C. jejuni, we sought to investigate whether serotonin can affect C. jejuni physiology and gut epithelial colonization in vitro. We first determined the biogeographical distribution of serotonin concentrations in the serosa, mucosa, as well as the luminal ...
- Handle:
- 10113/7231344
- DOI:
- 10.1016/j.psj.2020.12.041
- https://doi.org/10.1016/j.psj.2020.12.041
- Author:
- Luke A. Durkin; Caroline E. Childs; Philip C. Calder
- Source:
- Foods 2021 v.10 no.1 pp. -
- ISSN:
- 2304-8158
- Subject:
- B-lymphocytes; G-protein coupled receptors; alpha-linolenic acid; anti-inflammatory activity; cell membranes; cytokines; docosahexaenoic acid; docosapentaenoic acid; dosage; eicosanoids; eicosapentaenoic acid; endothelial cells; enterocytes; foods; histology; humans; intestinal absorption; literature; macrophages; models; monocytes; omega-3 fatty acids; permeability; peroxisome proliferator-activated receptors; prostaglandin synthase; research
- Abstract:
- ... Epithelial cells (enterocytes) form part of the intestinal barrier, the largest human interface between the internal and external environments, and responsible for maintaining regulated intestinal absorption and immunological control. Under inflammatory conditions, the intestinal barrier and its component enterocytes become inflamed, leading to changes in barrier histology, permeability, and chemi ...
- DOI:
- 10.3390/foods10010199
- https://doi.org/10.3390/foods10010199
- Author:
- Franziska Dengler; Anika Kraetzig; Gotthold Gäbel
- Source:
- Nutrients 2021 v.13 no.2 pp. -
- ISSN:
- 2072-6643
- Subject:
- butyrates; colon; fermentation; hypoxia; intestinal mucosa; propionic acid; protective effect; swine
- Abstract:
- ... The large intestinal epithelium is confronted with the necessity to adapt quickly to varying levels of oxygenation. In contrast to other tissues, it meets this requirement successfully and remains unharmed during (limited) hypoxic periods. The large intestine is also the site of bacterial fermentation producing short-chain fatty acids (SCFA). Amongst these SCFA, butyrate has been reported ...
- DOI:
- 10.3390/nu13020305
- https://doi.org/10.3390/nu13020305
- Author:
- Y. Choi; M. Yoon
- Source:
- Domestic animal endocrinology 2021 v.74 pp. 106535
- ISSN:
- 0739-7240
- Subject:
- epithelium, etc ; Thoroughbred; Western blotting; antibodies; boars; cytoplasm; endocrinology; fluorescent antibody technique; genes; humans; nasal cavity; odorant receptors; olfactory receptors; pheromones; reverse transcriptase polymerase chain reaction; vomeronasal organ; Show all 16 Subjects
- Abstract:
- ... Androstenone is the first mammalian steroidal pheromone to be identified. Pheromones are chemicals that animals use to communicate within a species. Pheromone detections are related to vomeronasal organ (VNO) and olfactory epithelium (OE) in mammals. Olfactory Receptor Family 7 Subfamily D Member 4 (OR7D4) is an odorant receptor that responds to androstenone. Several studies indicated that spray ...
- DOI:
- 10.1016/j.domaniend.2020.106535
- https://doi.org/10.1016/j.domaniend.2020.106535
- Author:
- Agustina Pascual; Emiliano S. Vilardo; Catalina Taibo; Julia Sabio y García; Rolando Rivera Pomar
- Source:
- Development genes and evolution 2021 v.231 no.1-2 pp. 33-45
- ISSN:
- 0949-944X
- Subject:
- epithelium, etc ; Chagas disease; Rhodnius prolixus; chorion; early development; eggs; evolution; genes; insects; oocytes; oogenesis; Show all 11 Subjects
- Abstract:
- ... (BicC) during oogenesis and early development of R. prolixus. We show that R. prolixus BicC (Rp-BicC) gene is expressed in the germarium, with cytoplasmic distribution, as well as in the follicular epithelium of the developing oocytes. RNAi silencing of Rp-BicC resulted in sterile females that lay few, small, non-viable eggs. The ovaries are reduced in size and show a disarray of the follicular ...
- DOI:
- 10.1007/s00427-021-00673-0
- https://doi.org/10.1007/s00427-021-00673-0
- Author:
- Shruti Ahlawat; Pramod Kumar; Hari Mohan; Sandeep Goyal; Krishna Kant Sharma
- Source:
- Critical reviews in microbiology 2021 v.47 no.2 pp. 254-273
- ISSN:
- 1549-7828
- Subject:
- cell proliferation; dietary supplements; disease control; etiology; health services; humans; hygiene; hypersensitivity; immune system; industrialization; intestinal microorganisms; intestinal mucosa; lifestyle; metabolism; mucosal immunity; pathogenesis; ulcerative colitis
- Abstract:
- ... inflammatory disorders of gut, mediated by complex interrelations among genetic, environmental, and internal factors. IBD has debateable aetiology, however in recent years, exploring the central role of a tri-directional relationship between gut microbiota, mucosal immune system, and intestinal epithelium in pathogenesis is getting the most attention. Increasing incidences and early onset explains ...
- DOI:
- 10.1080/1040841X.2021.1876631
- https://doi.org/10.1080/1040841X.2021.1876631
- Author:
- Adivitiya; Manish Singh Kaushik; Soura Chakraborty; Shobi Veleri; Suneel Kateriya
- Source:
- Biology 2021 v.10 no.2 pp. -
- ISSN:
- 2079-7737
- Subject:
- COVID-19 infection; Severe acute respiratory syndrome coronavirus 2; lung function; lungs; mucus; nasopharynx; pandemic; pathogens; pathophysiology; respiratory mucosa; rheology; transcription (genetics)
- Abstract:
- ... on the pathophysiology arising due to collapsed respiratory epithelium integrity such as abnormal ciliary movement, cilia loss and dysfunction, ciliated cell destruction, and changes in mucus rheology. The review includes protein interaction networks of coronavirus infection-manifested implications on the molecular machinery that regulates mucociliary clearance. We also provide an insight into the alteration ...
- DOI:
- 10.3390/biology10020095
- https://doi.org/10.3390/biology10020095
- Author:
- Jun He; Hongmei Xie; Daiwen Chen; Bing Yu; Zhiqing Huang; Xiangbing Mao; Ping Zheng; Yuheng Luo; Jie Yu; Junqiu Luo; Hui Yan
- Source:
- European journal of nutrition 2021 v.60 no.2 pp. 715-727
- ISSN:
- 1436-6207
- Subject:
- Bacteroides; Lactobacillus; Proteobacteria; acetates; apoptosis; butyrates; cecum; dietary fiber; epithelial cells; genes; glucagon-like peptide 2; histone deacetylase; ileum; ingestion; interleukin-6; intestinal microorganisms; inulin; secretion; swine; villi
- Abstract:
- ... levels of GPR43, GLP-2, and ZO-1, but decreased the expression levels of histone deacetylase 1 (HDAC1) and TNFα in the ileum and cecum mucosa (P < 0.05). Moreover, INU also elevated the expression levels of GPR109A and angiopoietin-4 (ANG-4) in the cecum mucosa (P < 0.05). CONCLUSIONS: This study indicated how the intestinal microbiome and epithelium adapt to inulin ingestion, and furthered our ...
- DOI:
- 10.1007/s00394-020-02284-3
- https://doi.org/10.1007/s00394-020-02284-3
- Author:
- Gabriel Miranda Moreira; Gleidson Luz Aguiar; Javier Andrés Moreno Meneses; Matheus Henrique da Luz; Maria Gabriela Borges Bahia Monteiro; Lorena Lara; Márcio Machado Ladeira; José Camisão de Souza; Marcio de Souza Duarte; Mateus Pies Gionbelli
- Source:
- Livestock science 2021 v.248 pp. 104496
- ISSN:
- 1871-1413
- Subject:
- rumen epithelium, etc ; 3-hydroxybutyric acid; beef; blood glucose; blood serum; cannulas; diet; energy; fetal development; gene expression; gestation period; glucose; heart; heart rate; inflammation; metabolism; physiological state; pregnancy; respiratory rate; urea; zebu; Show all 21 Subjects
- Abstract:
- ... The present study aimed to investigate metabolic and physiological changes induced by pregnancy, as well as the expression of key genes linked to the absorptive and proliferative activity of the ruminal epithelium towards the end of the gestational period in zebu beef heifers. Twelve ruminally cannulated Zebu beef heifers were randomly assigned into two experimental treatments: a pregnant group ...
- DOI:
- 10.1016/j.livsci.2021.104496
- https://doi.org/10.1016/j.livsci.2021.104496