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1. Interaction with ectopic cochlear crista sensory epithelium disrupts basal cochlear sensory epithelium development in Lmx1a mutant mice

Author:
Nichols, David H.; Bouma, Judith E.; Kopecky, Benjamin J.; Jahan, Israt; Beisel, Kirk W.; He, David Z. Z.; Liu, Huizhan; Fritzsch, Bernd
Source:
Cell and tissue research 2020 v.380 no.3 pp. 435-448
ISSN:
0302-766X
Subject:
epithelium,   etc   ; ears; mice; mutants; transcription factors;     Show all 5 Subjects
Abstract:
... The LIM homeodomain transcription factor Lmx1a shows a dynamic expression in the developing mouse ear that stabilizes in the non-sensory epithelium. Previous work showed that Lmx1a functional null mutants have an additional sensory hair cell patch in the posterior wall of a cochlear duct and have a mix of vestibular and cochlear hair cells in the basal cochlear sensory epithelium. In E13.5 mutants ...
DOI:
10.1007/s00441-019-03163-y

2. Functional domains of the FgfrL1 receptor

Author:
Gerber, Simon D.; Beauchamp, Philippe; Zhuang, Lei; Villiger, Peter M.; Trueb, Beat
Source:
Developmental biology 2020 v.461 no.1 pp. 43-54
ISSN:
0012-1606
Subject:
epithelium,   etc   ; diaphragm; kidneys; ligands; longevity; lungs; mice;     Show all 7 Subjects
Abstract:
... FgfrL1 is a novel growth factor receptor that is primarily expressed in musculoskeletal tissues and the kidney. FgfrL1-deficient mice have a malformed diaphragm and no kidneys. Such animals die immediately after birth because they are not able to inflate their lungs.The FgfrL1 molecule is composed of three extracellular Ig domains, a transmembrane helix and a short intracellular domain. To investi ...
DOI:
10.1016/j.ydbio.2020.01.003

3. Optic vesicle morphogenesis requires primary cilia

Author:
Fiore, Luciano; Takata, Nozomu; Acosta, Sandra; Ma, Wanshu; Pandit, Tanushree; Oxendine, Michael; Oliver, Guillermo
Source:
Developmental biology 2020 v.462 no.2 pp. 119-128
ISSN:
0012-1606
Subject:
epithelium,   etc   ; cilia; ectoderm; embryo (animal); genes; mice; morphogenesis; phenotype; retina;     Show all 9 Subjects
Abstract:
... Arl13b is a gene known to regulate ciliogenesis. Functional alterations in this gene's activity have been associated with Joubert syndrome. We found that in Arl13 null mouse embryos the orientation of the optic cup is inverted, such that the lens is abnormally surrounded by an inverted optic cup whose retina pigmented epithelium is oddly facing the surface ectoderm. Loss of Arl13b leads to the dis ...
DOI:
10.1016/j.ydbio.2020.02.016

4. The copulatory apparatus of the marine gastropod Haminella solitaria (Heterobranchia: Cephalaspidea) and its phylogenetic relevance

Author:
Lobo‐da‐Cunha, Alexandre; Alves, Ângela; Oliveira, Elsa; Wranik, Wolfgang; Malaquias, Manuel António E.
Source:
Invertebrate biology 2020 v.139 no.1 pp. e12281
ISSN:
1077-8306
Subject:
epithelium,   etc   ; Cephalaspidea; Navicula; hermaphroditism; histology; phylogeny; pouches; snails; spermatozoa; vacuoles;     Show all 10 Subjects
Abstract:
... The hermaphroditic marine snail species Haminella solitaria was formerly included in the genus Haminoea, but it was recently assigned to the genus Haminella. The copulatory apparatus in H. solitaria was investigated by light and transmission electron microscopy to obtain additional information about this apparatus in cephalaspidean gastropods and to evaluate the taxonomic relevance of its morphofu ...
DOI:
10.1111/ivb.12281

5. Molecular Mobility-Mediated Regulation of E-Cadherin Adhesion

Author:
Biswas, Kabir H.
Source:
Trends in biochemical sciences 2020 v.45 no.2 pp. 163-173
ISSN:
0968-0004
Subject:
epithelium,   etc   ; adhesion; cadherins; cytoskeleton; endocytosis; gene expression; organogenesis; receptors;     Show all 8 Subjects
Abstract:
... Cells in epithelial tissues utilize homotypic E-cadherin interaction-mediated adhesions to both physically adhere to each other and sense the physical properties of their microenvironment, such as the presence of other cells in close vicinity or an alteration in the mechanical tension of the tissue. These position E-cadherin centrally in organogenesis and other processes, and its function is there ...
DOI:
10.1016/j.tibs.2019.10.012

6. Staphylococci in the human microbiome: the role of host and interbacterial interactions

Author:
Otto, Michael
Source:
Current opinion in microbiology 2020 v.53 pp. 71-77
ISSN:
1369-5274
Subject:
epithelium,   etc   ; Staphylococcus aureus; humans; microbiome; microorganisms; pathogenicity; staphylococcal infections;     Show all 7 Subjects
Abstract:
... Staphylococci are common commensals on human epithelial surfaces. Some species, most notably Staphylococcus aureus, have considerable pathogenic potential and can cause severe and sometimes fatal infections. Despite the long-known fact that staphylococcal infection arises from colonizing isolates, research on staphylococcal colonization has been limited, in particular regarding interactions with t ...
DOI:
10.1016/j.mib.2020.03.003

7. Early ear neuronal development, but not olfactory or lens development, can proceed without SOX2

Author:
Dvorakova, Martina; Macova, Iva; Bohuslavova, Romana; Anderova, Miroslava; Fritzsch, Bernd; Pavlinkova, Gabriela
Source:
Developmental biology 2020 v.457 no.1 pp. 43-56
ISSN:
0012-1606
Subject:
epithelium,   etc   ; brain; eyes; ganglia; inner ear; neurogenesis; neurons; stem cells;     Show all 8 Subjects
Abstract:
... SOX2 is essential for maintaining neurosensory stem cell properties, although its involvement in the early neurosensory development of cranial placodes remains unclear. To address this, we used Foxg1-Cre to conditionally delete Sox2 during eye, ear, and olfactory placode development. Foxg1-Cre mediated early deletion of Sox2 eradicates all olfactory placode development, and disrupts retinal develo ...
DOI:
10.1016/j.ydbio.2019.09.003
PubMed:
31526806
PubMed Central:
PMC6938654

8. Foxa1 and Foxa2 orchestrate development of the urethral tube and division of the embryonic cloaca through an autoregulatory loop with Shh

Author:
Gredler, Marissa L.; Patterson, Sara E.; Seifert, Ashley W.; Cohn, Martin J.
Source:
Developmental biology 2020 v.465 no.1 pp. 23-30
ISSN:
0012-1606
Subject:
epithelium,   etc   ; cell cycle; congenital abnormalities; female genitalia; fistula; genes; males; penis; urethra;     Show all 9 Subjects
Abstract:
... Congenital anomalies of external genitalia affect approximately 1 in 125 live male births. Development of the genital tubercle, the precursor of the penis and clitoris, is regulated by the urethral plate epithelium, an endodermal signaling center. Signaling activity of the urethral plate is mediated by Sonic hedgehog (SHH), which coordinates outgrowth and patterning of the genital tubercle by cont ...
DOI:
10.1016/j.ydbio.2020.06.009

9. Rab11 is essential for lgl mediated JNK–Dpp signaling in dorsal closure and epithelial morphogenesis in Drosophila

Author:
Nandy, Nabarun; Roy, Jagat Kumar
Source:
Developmental biology 2020 v.464 no.2 pp. 188-201
ISSN:
0012-1606
Subject:
epithelium,   etc   ; Drosophila; embryogenesis; imagos; morphogenesis; phenotype; signal transduction; thorax; tissue repair; tumor suppressor genes;     Show all 10 Subjects
Abstract:
... Dorsal closure during Drosophila embryogenesis provides a robust genetic platform to study the basic cellular mechanisms that govern epithelial wound healing and morphogenesis. As dorsal closure proceeds, the lateral epithelial tissue (LE) adjacent to the dorsal opening advance contra-laterally, with a simultaneous retraction of the amnioserosa. The process involves a fair degree of coordinated ce ...
DOI:
10.1016/j.ydbio.2020.06.005

10. ZEB and Snail expression indicates epithelial-mesenchymal transition in canine melanoma

Author:
Veloso, Emerson Soares; Gonçalves, Ivy Nayra Nascimento; Silveira, Tatiany Luiza; Espirito Santo, Juliane Taynar; Figueiredo, Larissa Vieira; Varaschin, Mary Suzan; Cassali, Geovanni Dantas; Del Puerto, Helen Lima; Ferreira, Enio
Source:
Research in veterinary science 2020 v.131 pp. 7-14
ISSN:
0034-5288
Subject:
epithelium,   etc   ; cadherins; cell adhesion; cell membranes; cytoplasm; dogs; melanoma; neoplasm cells; protein synthesis; transcription factors;     Show all 10 Subjects
Abstract:
... Melanoma progression is associated with the epithelial-mesenchymal transition (EMT) when tumor cells reduce E-cadherin and increase N-cadherin expression resulting in an escape from the microenvironment via loss of cellular adhesion and gain of motility. Transcription factor proteins Snail and ZEB trigger EMT by repression of epithelial markers and activation of mesenchymal properties. This study ...
DOI:
10.1016/j.rvsc.2020.04.007

11. Zebrafish can regenerate endoskeleton in larval pectoral fin but the regenerative ability declines

Author:
Yoshida, Keigo; Kawakami, Koichi; Abe, Gembu; Tamura, Koji
Source:
Developmental biology 2020 v.463 no.2 pp. 110-123
ISSN:
0012-1606
Subject:
epithelium,   etc   ; Danio rerio; adults; amputation; chondrocytes; ectoderm; genes; genetic markers; larvae; larval development; mammals; models;     Show all 12 Subjects
Abstract:
... We show for the first time endoskeletal regeneration in the developing pectoral fin of zebrafish. The developing pectoral fin contains an aggregation plate of differentiated chondrocytes (endochondral disc; primordium for endoskeletal components, proximal radials). The endochondral disc can be regenerated after amputation in the middle of the disc. The regenerated disc sufficiently forms endoskele ...
DOI:
10.1016/j.ydbio.2020.04.010

12. Exosome-associated SUMOylation mutant AAV demonstrates improved ocular gene transfer efficiency in vivo

Author:
Maurya, Shubham; Jayandharan, Giridhara R.
Source:
Virus research 2020 v.283 pp. 197966
ISSN:
0168-1702
Subject:
epithelium,   etc   ; Dependoparvovirus; capsid; exosomes; gene therapy; gene transfer; humans; mice; mutants; packaging; permeability; reporter genes; sumoylation;     Show all 13 Subjects
Abstract:
... Exosome associated Adeno-associated virus (AAV) vectors have emerged as a promising tool in gene therapy. Recently, we elucidated the role of SUMOylation post-translational modification in AAV2 capsid and demonstrated that capsid modifications at SUMOylation sites, enhance vector transduction. The present study was designed to study the combinatorial effect of exosome delivery of a SUMOylation sit ...
DOI:
10.1016/j.virusres.2020.197966
PubMed:
32302639
PubMed Central:
PMC7212041

13. Alternative pathways control actomyosin contractility in epitheliomuscle cells during morphogenesis and body contraction

Author:
Holz, Oliver; Apel, David; Hassel, Monika
Source:
Developmental biology 2020 v.463 no.1 pp. 88-98
ISSN:
0012-1606
Subject:
epithelium,   etc   ; Hydra; adults; ectoderm; morphogenesis; muscles; myosin; myosin light chain kinase; phosphorylation;     Show all 9 Subjects
Abstract:
... In adult Hydra, epitheliomuscle cells form the monolayered ecto- and endodermal epithelia. Their basal myonemes function as a longitudinal and circular muscle, respectively. Based on the observation that a Rho/Rock pathway, controlling the cell shape changes during detachment of Hydra buds, is not involved in body movement, at least two actomyosin compartments must exist in these cells: a basal on ...
DOI:
10.1016/j.ydbio.2020.04.001

14. Cytotoxic effects in transformed and non-transformed human breast cell lines after exposure to silver nanoparticles in combination with selected aluminium compounds, parabens or phthalates

Author:
Roszak, J.; Smok-Pieniążek, A.; Spryszyńska, S.; Kowalczyk, K.; Domeradzka-Gajda, K.; Świercz, R.; Grobelny, J.; Tomaszewska, E.; Ranoszek-Soliwoda, K.; Celichowski, G.; Cieślak, M.; Puchowicz, D.; Stępnik, M.
Source:
Journal of hazardous materials 2020 v.392 pp. 122442
ISSN:
0304-3894
Subject:
epithelium,   etc   ; aluminum chloride; breasts; cell cycle; cytotoxicity; humans; nanosilver; oxidative stress; phthalates; physicochemical properties; synergism; viability;     Show all 12 Subjects
Abstract:
... This study was undertaken to assess cytotoxic effects of selected aluminium compounds, parabens and phthalates in combination with silver nanoparticles (AgNP, 15 and 45 nm by STEM, Ag15 and Ag45, respectively) on cell lines of the human breast epithelium, normal (MCF-10A) and transformed (MDA-MB-231 and MCF-7).Combination indices were the most spectacular at effective concentrations (ED) inducing ...
DOI:
10.1016/j.jhazmat.2020.122442

15. Formation and contraction of multicellular actomyosin cables facilitate lens placode invagination

Author:
Houssin, Nathalie S.; Martin, Jessica B.; Coppola, Vincenzo; Yoon, Sung Ok; Plageman, Timothy F.
Source:
Developmental biology 2020 v.462 no.1 pp. 36-49
ISSN:
0012-1606
Subject:
epithelium,   etc   ; actin; chicks; cytoskeleton; deformation; embryo (animal); enzymes; fluorescence microscopy; guanine; immunohistochemistry; mice; morphogenesis; myosin;     Show all 13 Subjects
Abstract:
... Embryonic morphogenesis relies on the intrinsic ability of cells, often through remodeling the cytoskeleton, to shape epithelial tissues during development. Epithelial invagination is an example of morphogenesis that depends on this remodeling but the cellular mechanisms driving arrangement of cytoskeletal elements needed for tissue deformation remain incompletely characterized. To elucidate these ...
DOI:
10.1016/j.ydbio.2020.02.014
PubMed:
32113830
PubMed Central:
PMC7225080

16. Epstein-Barr virus-infected plasma cells in periodontitis lesions

Author:
Olivieri, Charles V.; Raybaud, Hélène; Tonoyan, Lilit; Abid, Sarah; Marsault, Robert; Chevalier, Marlène; Doglio, Alain; Vincent-Bugnas, Séverine
Source:
Microbial pathogenesis 2020 v.143 pp. 104128
ISSN:
0882-4010
Subject:
epithelium,   etc   ; Human gammaherpesvirus 4; T-lymphocytes; models; pathogens; patients; periodontitis; plasma cells; saliva; therapeutics; virus replication;     Show all 11 Subjects
Abstract:
... Growing evidence supports that the Epstein-Barr virus (EBV) is a putative periodontal pathogen, but little is known regarding EBV behavior in periodontitis. Here, EBV infection was monitored in saliva and periodontal pocket (PP), at baseline and 3 months after periodontal non-surgical therapy (p-NST) in 20 patients diagnosed with periodontitis. After the treatment, the patients with the improved p ...
DOI:
10.1016/j.micpath.2020.104128

17. The Microbiome Sets the Stage for Cholera

Author:
Sokol, Nicholas S.; Newton, Irene L.G.
Source:
Trends in microbiology 2020 v.28 no.6 pp. 430-432
ISSN:
0966-842X
Subject:
epithelium,   etc   ; Drosophila; Vibrio cholerae; cholera; microbial communities; microbiome; models; pathogens; type VI secretion system;     Show all 9 Subjects
Abstract:
... Interactions between the eukaryotic host, microbiome members, and invading pathogens help to shape disease outcomes. Using the Drosophila model, Fast et al. identified that Vibrio cholerae acts to inhibit epithelial renewal through complex interactions between the type VI secretion system of V. cholerae and the microbial community of the fly. ...
DOI:
10.1016/j.tim.2020.03.002

18. Regenerative Metaplastic Clones in COPD Lung Drive Inflammation and Fibrosis

Author:
Rao, Wei; Wang, Shan; Duleba, Marcin; Niroula, Suchan; Goller, Kristina; Xie, Jingzhong; Mahalingam, Rajasekaran; Neupane, Rahul; Liew, Audrey-Ann; Vincent, Matthew; Okuda, Kenichi; O’Neal, Wanda K.; Boucher, Richard C.; Dickey, Burton F.; Wechsler, Michael E.; Ibrahim, Omar; Engelhardt, John F.; Mertens, Tinne C.J.; Wang, Wei; Jyothula, Soma S.K.; Crum, Christopher P.; Karmouty-Quintana, Harry; Parekh, Kalpaj R.; Metersky, Mark L.; McKeon, Frank D.; Xian, Wa
Source:
Cell 2020 v.181 no.4 pp. 848-864.e18
ISSN:
0092-8674
Subject:
epithelium,   etc   ; bronchitis; clones; fibrosis; hypersecretion; inflammation; lungs; metaplasia; mice; monitoring; mucus; patients; pulmonary emphysema; stem cells;     Show all 14 Subjects
Abstract:
... Chronic obstructive pulmonary disease (COPD) is a progressive condition of chronic bronchitis, small airway obstruction, and emphysema that represents a leading cause of death worldwide. While inflammation, fibrosis, mucus hypersecretion, and metaplastic epithelial lesions are hallmarks of this disease, their origins and dependent relationships remain unclear. Here we apply single-cell cloning tec ...
DOI:
10.1016/j.cell.2020.03.047

19. Revealing new leads for the impact of galacto-oligosaccharides on gut commensals and gut health benefits through text mining

Author:
Sijbers, A.M.; Schoemaker, R.J.W.; Nauta, A.; Alkema, W.
Source:
Beneficial microbes 2020 v.11 no.3 pp. 283-302
ISSN:
1876-2891
Subject:
epithelium,   etc   ; Bifidobacterium; DNA fingerprinting; constipation; databases; digestive system; ecosystems; galactooligosaccharides; humans; metagenomics; ribosomal DNA;     Show all 11 Subjects
Abstract:
... Galacto-oligosaccharides (GOS) are linked to various health benefits, such as the relief of symptoms of constipation. Part of the beneficial effects of GOS are thought to be the consequence of their bifidogenic effect, stimulating the growth of several Bifidobacterium species in vivo. However, GOS may exert additional effects by directly stimulating other bacterial species or by effects that bifid ...
DOI:
10.3920/BM2019.0105

20. An easy-to-prepare microshotgun for efficient transmembrane delivery by powering nanoparticles

Author:
Liang, Zhongping; Yu, Hang; Lai, Jianfeng; Wen, Lu; Chen, Gang
Source:
Journal of controlled release 2020 v.321 pp. 119-131
ISSN:
0168-3659
Subject:
epithelium,   etc   ; blood; cytotoxicity; equipment; histology; inner ear; magnetic fields; middle ear; nanoparticles; pathogens;     Show all 10 Subjects
Abstract:
... Biological barriers are the first line of defense against pathogen invasions, but they can also present as critical obstacles to drug delivery. Despite a variety of strategies have been developed recently to overcome them, significant efforts are still needed to achieve safer and more effective drug delivery. Herein, we constructed a metal-free, “slim waist” shaped microshotgun delivery device, wh ...
DOI:
10.1016/j.jconrel.2020.02.016