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1. Anchoring red blood cell with tetrahedral DNA nanostructure: Electrochemical biosensor for the sensitive signage of circulating tumor DNA

Author:
Xinyue Zha; Weiwei Qin; Jiadi Chen; Mengting Chen; Qiyue Zhang; Kaiyu He; Yingju Liu; Weipeng Liu
Source:
Talanta 2023 v.251 pp. 123793
ISSN:
0039-9140
Subject:
erythrocytes,   etc   ; DNA; biocompatibility; biosensors; blood serum; detection limit; methylene blue; neoplasms; rapid methods;     Show all 9 Subjects
Abstract:
... Circulating tumor cells (CTCs), as a type of tumor, have attracted wide attention because of their characteristics of shedding from the primary tumor and spreading to other tissues and organs through peripheral blood. The circulating tumor DNA (ctDNA), the DNA released by CTCs and other tumor cells into the peripheral blood, was considered as a promising detection substance for clinical applicatio ...
DOI:
10.1016/j.talanta.2022.123793

2. Exposure to polystyrene nanoplastics induces an anxiolytic-like effect, changes in antipredator defensive response, and DNA damage in Swiss mice

Author:
Abraão Tiago Batista Guimarães; Ítalo Nascimento Freitas; Nabisab Mujawar Mubarak; Md. Mostafizur Rahman; Fernando Postalli Rodrigues; Aline Sueli de Lima Rodrigues; Damià Barceló; Abu Reza Md. Towfiqul Islam; Guilherme Malafaia
Source:
Journal of hazardous materials 2023 v.442 pp. 130004
ISSN:
0304-3894
Subject:
erythrocytes,   etc   ; DNA damage; Pantherophis guttatus; antioxidant activity; antipredatory behavior; biomarkers; brain; comet assay; dose response; ecotoxicology; glutathione; locomotion; males; mice; nanoplastics; polystyrenes; principal component analysis; risk; snakes; toxicity;     Show all 20 Subjects
Abstract:
... Although the in vivo toxicity of nanoplastics (NPs) has already been reported in different model systems, their effects on mammalian behavior are poorly understood. Thus, we aimed to evaluate whether exposure to polystyrene (PS) NPs (diameter: 23.03 ± 0.266 nm) alters the behavior (locomotor, anxiety-like and antipredator) of male Swiss mice, induces brain antioxidant activity, and erythrocyte DNA ...
DOI:
10.1016/j.jhazmat.2022.130004

3. Design of erythrocyte-derived carriers for bioimaging applications

Author:
Wing-Fu Lai; Dahong Zhang; Wing-Tak Wong
Source:
Trends in biotechnology 2022 pp. -
ISSN:
0167-7799
Subject:
erythrocytes,   etc   ; bioimaging; biotechnology; drugs;     Show all 4 Subjects
Abstract:
... Erythrocytes are physiological entities that have been exploited in both preclinical and clinical trials for the delivery of exogenous agents. Over the years, diverse erythrocyte-derived carriers (ECs) have been developed with related patents granted for industrial and commercial purposes. However, most ECs have only been exploited for drug delivery. Serious discussions regarding their application ...
DOI:
10.1016/j.tibtech.2022.07.010

4. Rosettes: a shield for Plasmodium falciparum against artemisinins?

Author:
Stephen J. Rogerson
Source:
Trends in parasitology 2022 v.38 no.3 pp. 193-194
ISSN:
1471-4922
Subject:
erythrocytes,   etc   ; Plasmodium falciparum; genes; parasitology;     Show all 4 Subjects
Abstract:
... Relative resistance of Plasmodium falciparum parasites to artesunate (AS) has been ascribed to mutations in the Kelch 13 gene. Lee et al. describe another potential contributor to resistance: the induction of increased rosetting by trophozoite-infected erythrocytes following short exposures to AS. Dissecting this phenomenon may lead to new insights into AS resistance. ...
DOI:
10.1016/j.pt.2021.12.009

5. Hemotropic mycoplasmas (hemoplasmas) in wild boars, hunting dogs, and hunters from two Brazilian regions

Author:
Asia Janelle Fernandes; Nelly Ossama Elshafie; Louise Bach Kmetiuk; Leila Sabrina Ullmann; Ana Pérola Drulla Brandão; Amanda Haisi; Renato van Wilpe Bach; Ivan Roque de Barros‐Filho; João Pessoa Araújo Junior; David Soeiro Barbosa; Alexander Welker Biondo; Andrea Pires dos Santos
Source:
Transboundary and emerging diseases 2022 v.69 no.2 pp. 908-912
ISSN:
1865-1674
Subject:
erythrocytes,   etc   ; Mycoplasma; humans; risk; Brazil;     Show all 5 Subjects
Abstract:
... Haemotropic mycoplasmas (haemoplasmas) are small pleomorphic bacteria infecting erythrocytes of several mammalian species, including human beings. No study to date has focused on the risk of bacteria exposure in hunting activities, particularly in natural environments of highly tick‐infested areas. Accordingly, the present study aimed to assess haemoplasma occurrence in the complex encompassing wi ...
DOI:
10.1111/tbed.14038

6. Erythrocyte (red blood cell) dataset in thalassemia case

Author:
Dyah Aruming Tyas; Tri Ratnaningsih; Agus Harjoko; Sri Hartati
Source:
Data in Brief 2022 v.41 pp. 107886
ISSN:
2352-3409
Subject:
erythrocytes,   etc   ; cameras; color; data collection; thalassemia;     Show all 5 Subjects
Abstract:
... Red blood cell (RBC) dataset was obtained from four thalassemia peripheral blood smears and a healthy peripheral blood smear. The dataset contains 7108 images of individual red blood cells for nine cell types. The first process is image acquisition, which is the process of retrieving microscopic image data from peripheral blood smears through a Olympus CX21 microscope using an Optilab advance plus ...
DOI:
10.1016/j.dib.2022.107886

7. Probing the Interaction Between Supercarrier RBC Membrane and Nanoparticles for Optimal Drug Delivery

Author:
Shuo Wang; Shuhao Ma; Rongxin Li; Xiaojing Qi; Keqin Han; Ling Guo; Xuejin Li
Source:
Journal of molecular biology 2022 pp. 167539
ISSN:
0022-2836
Subject:
erythrocytes,   etc   ; adhesion; blood flow; drugs; molecular biology;     Show all 5 Subjects
Abstract:
... Red blood cell (RBC) membrane-hitchhiking nanoparticles (NPs) have been an increasingly popular supercarrier for targeted drug delivery. However, the kinetic details of the shear-induced NP detachment process from RBC in blood flow remain unclear. Here, we perform detailed computational simulations of the traversal dynamics of an RBC-NP composite supercarrier with tunable properties. We show that ...
DOI:
10.1016/j.jmb.2022.167539

8. The effect of Iodixanol on the thermodynamic properties of blood components

Author:
Zoltán Ujfalusi; Elek Telek; Miklós Nyitrai; Péter Bogner; Tamás Rostás; Gabriella Hild; László Trif; Gábor Hild
Source:
Thermochimica acta 2022 v.710 pp. 179165
ISSN:
0040-6031
Subject:
erythrocytes,   etc   ; blood serum; humans; phase transition; temperature;     Show all 5 Subjects
Abstract:
... The effects of Iodixanol contrast medium were studied on human blood samples with differential scanning calorimetry (DSC). Measurements on anticoagulated and non-anticoagulated samples revealed that the components of the plasma and serum turned into a thermodynamically less stable state in the presence of Iodixanol. The thermal parameters of the main transition peak changed in the same way for bot ...
DOI:
10.1016/j.tca.2022.179165

9. The effect of flavonoids on the reduction of cupric ions, the copper-driven Fenton reaction and copper-triggered haemolysis

Author:
Zuzana Lomozová; Marcel Hrubša; Palma Federica Conte; Eugenia Papastefanaki; Monika Moravcová; Maria Carmen Catapano; Ilaria Proietti Silvestri; Jana Karlíčková; Radim Kučera; Kateřina Macáková; Přemysl Mladěnka
Source:
Food chemistry 2022 v.394 pp. 133461
ISSN:
0308-8146
Subject:
erythrocytes,   etc   ; antioxidants; flavones; food chemistry; hemolysis; models;     Show all 6 Subjects
Abstract:
... Flavonoids are considered beneficial, but they may exhibit pro-oxidative effects likely due to metal reducing properties. For the first time, 24 structurally related flavonoids were compared for copper reduction, and modulation of the copper-triggered Fenton reaction and lysis of erythrocytes. The vast majority of flavonoids reduced cupric ions; their behaviour ranged from progressive gradual redu ...
DOI:
10.1016/j.foodchem.2022.133461

10. Three‐dimensional architecture of Cyrilia lignieresi gametocyte‐stage development inside red blood cells

Author:
Maíra Turiel‐Silva; Camila Wendt; Edilene O. Silva; Ana Paula Drummond Rodrigues; Wanderley de Souza; Kildare Miranda; José A. P. Diniz
Source:
journal of eukaryotic microbiology 2022 v.69 no.3 pp. e12894
ISSN:
1066-5234
Subject:
erythrocytes,   etc   ; Haemogregarinidae; Protozoa; cytoplasm; fish; microbiology; parasites; tomography;     Show all 8 Subjects
Abstract:
... The Haemogregarinidae family (Apicomplexa: Adeleina) comprises hemoprotozoa that infect mammals, birds, amphibians, fish, and reptiles. Some morphological characteristics of the Cyrilia lignieresi have been described previously, but the parasite–erythrocyte relationship is still poorly understood. In order to understand the structural architecture of C. lignieresi‐infected red blood cells, electro ...
DOI:
10.1111/jeu.12894

11. Methods: A new protocol for in vitro red blood cell glycation

Author:
Marcus V. Batista da Silva; Analía I. Alet; Horacio V. Castellini; Bibiana D. Riquelme
Source:
Comparative biochemistry and physiology 2022 v.264 pp. 111109
ISSN:
1095-6433
Subject:
erythrocytes,   etc   ; diabetes; glucose; glycation; glycohemoglobin; hyperglycemia; models; temperature; viscoelasticity;     Show all 9 Subjects
Abstract:
... During diabetes, the characteristic hyperglycemia can induce red blood cell glycation. Several researchers have proposed different protocols to perform an in vitro model to study this phenomenon. In this article, some of the most important in vitro glycation protocols available in the bibliography were compared to each other. The incubation parameters as the suspension medium, glucose concentratio ...
DOI:
10.1016/j.cbpa.2021.111109

12. Ice Recrystallization Inhibition Is Insufficient to Explain Cryopreservation Abilities of Antifreeze Proteins

Author:
Yuling Sun; Daria Maltseva; Jie Liu; Theordore Hooker; Volker Mailänder; Hans Ramløv; Arthur L. DeVries; Mischa Bonn; Konrad Meister
Source:
Biomacromolecules 2022 v.23 no.3 pp. 1214-1220
ISSN:
1526-4602
Subject:
erythrocytes,   etc   ; cold storage; cryopreservation; cryoprotectants; crystallization; glycoproteins; humans; ice;     Show all 8 Subjects
Abstract:
... Antifreeze proteins (AFPs) and glycoproteins (AFGPs) are exemplary at modifying ice crystal growth and at inhibiting ice recrystallization (IRI) in frozen solutions. These properties make them highly attractive for cold storage and cryopreservation applications of biological tissue, food, and other water-based materials. The specific requirements for optimal cryostorage remain unknown, but high IR ...
DOI:
10.1021/acs.biomac.1c01477

13. Housebreaking Plasmodium parasites leave their fingerprints at the door

Author:
Lara Bardtke; Ian A. Cockburn
Source:
Trends in parasitology 2022 pp. -
ISSN:
1471-4922
Subject:
erythrocytes,   etc   ; Plasmodium falciparum; malaria; merozoites; parasitology; phagocytosis; vaccine development;     Show all 7 Subjects
Abstract:
... Protective antibodies against Plasmodium falciparum merozoite antigens, including EBA-175, can inhibit erythrocyte invasion. New data from Musasia et al. indicate that these antibodies can also trigger antibody-dependent phagocytosis of ring-infected and uninfected erythrocytes and that this correlates with protection from malaria. This provides a new pathway for vaccine design. ...
DOI:
10.1016/j.pt.2022.09.005

14. In vitro effect of high glucose concentrations on erythrocyte morphology assessed by scanning electron microscopy

Author:
Alejandra Loyola-Leyva; Luz E. Alcántara-Quintana; Yolanda Terán-Figueroa; Francisco Javier González
Source:
Micron 2022 v.154 pp. 103179
ISSN:
0968-4328
Subject:
erythrocytes,   etc   ; cell viability; diabetes; glucose; tetrazolium; time series analysis;     Show all 6 Subjects
Abstract:
... To evaluate the in vitro effect of different glucose concentrations and the time series in erythrocyte cell viability and morphology parameters.Different glucose concentrations were assessed, from a normal physiological glucose concentration (5 mM) to a diabetes scenario (100 mM). Cell viability was obtained by the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) assay. The eryt ...
DOI:
10.1016/j.micron.2021.103179

15. Chimeric mutants of staphylococcal hemolysin, which act as both one‐component and two‐component hemolysin, created by grafting the stem domain

Author:
Nouran Ghanem; Natsuki Kanagami; Takashi Matsui; Kein Takeda; Jun Kaneko; Yasuyuki Shiraishi; Christian A. Choe; Tomomi Uchikubo‐Kamo; Mikako Shirouzu; Tsubasa Hashimoto; Tomohisa Ogawa; Tomoaki Matsuura; Po‐Ssu Huang; Takeshi Yokoyama; Yoshikazu Tanaka
Source:
FEBS journal 2022 v.289 no.12 pp. 3505-3520
ISSN:
1742-464X
Subject:
erythrocytes,   etc   ; Staphylococcus aureus; cell membranes; electron microscopy; hemolysins; transmembrane proteins;     Show all 6 Subjects
Abstract:
... Staphylococcus aureus expresses several hemolytic pore‐forming toxins (PFTs), which are all commonly composed of three domains: cap, rim and stem. PFTs are expressed as soluble monomers and assemble to form a transmembrane β‐barrel pore in the erythrocyte cell membrane. The stem domain undergoes dramatic conformational changes to form a pore. Staphylococcal PFTs are classified into two groups: one ...
DOI:
10.1111/febs.16354

16. Determination of red blood cell adhesion to vascular endothelial cells: A critical role for blood plasma

Author:
Gregory Barshtein; Orly Zelig; Alexander Gural; Dan Arbell; Saul Yedgar
Source:
Colloids and surfaces 2022 v.210 pp. 112226
ISSN:
0927-7765
Subject:
erythrocytes,   etc   ; adhesion; blood plasma; cell adhesion; humans; pathophysiology; shear stress;     Show all 7 Subjects
Abstract:
... Red blood cell (RBC) adhesion to vascular endothelial cells (EC) is considered a potent effector of circulatory disorders, and its enhancement is implicated in the pathophysiology of numerous conditions, mainly hemoglobinopathies. The actual RBC/EC interaction is determined by both cellular and plasmatic factors, and the differentiation between them is essential for understanding its physiological ...
DOI:
10.1016/j.colsurfb.2021.112226

17. Evolving perspectives on rosetting in malaria

Author:
Wenn-Chyau Lee; Bruce Russell; Laurent Rénia
Source:
Trends in parasitology 2022 v.38 no.10 pp. 882-889
ISSN:
1471-4922
Subject:
erythrocytes,   etc   ; Plasmodium falciparum; drug development; drug resistance; humans; malaria; parasitology;     Show all 7 Subjects
Abstract:
... The ability of the intraerythrocytic Plasmodium spp. to form spontaneous rosettes with uninfected red blood cells (URBCs) has been observed in the medically important malaria parasites. Since the discovery of rosettes in the late 1980s, different formation mechanisms and pathobiological roles have been postulated for rosetting; most of which have focused on Plasmodium falciparum. Recent breakthrou ...
DOI:
10.1016/j.pt.2022.08.001

18. Genotoxic Effect of Unused and Banned Pesticides on the Body of Cattle Kept on the Territory of South Kazakhstan

Author:
A. A. Kornilova; R. Zh. Zhapbasov; A. M. Zhomartov; A. K. Sibataev; D. A. Begimbetova; B. O. Bekmanov
Source:
Contemporary problems of ecology 2022 v.15 no.2 pp. 180-187
ISSN:
1995-4255
Subject:
erythrocytes,   etc   ; cattle; ecology; farms; genomics; genotoxicity; metabolites; mutagens; polyploidy; Kazakhstan;     Show all 10 Subjects
Abstract:
... On the territory of South Kazakhstan (Almaty region) there are old abandoned warehouses with prohibited and unused pesticides, the active substances and metabolites of which pollute natural water sources and pastures of farm animals located nearby. The analysis of blood samples of 50 heads of cattle from five monitoring points of the Almaty region was carried out for the presence of micronuclei in ...
DOI:
10.1134/S1995425522020044

19. Identification of Exported Plasmodium falciparum Proteins That Bind to the Erythrocyte Cytoskeleton

Author:
Bikash Shakya; Geoffrey Kimiti Kilili; Ling Wang; Ernesto S. Nakayasu; Douglas J. LaCount
Source:
Microorganisms 2022 v.10 no.7 pp. -
ISSN:
2076-2607
Subject:
erythrocytes,   etc   ; Plasmodium falciparum; cytoskeleton; erythrocyte membrane; exports; mass spectrometry; parasites;     Show all 7 Subjects
Abstract:
... Plasmodium proteins are exported to the erythrocyte cytoplasm to create an environment that supports parasite replication. Although hundreds of proteins are predicted to be exported through Plasmodium export element (PEXEL)-dependent and -independent mechanisms, the functions of exported proteins are largely uncharacterized. In this study, we used a biochemical screening approach to identify putat ...
DOI:
10.3390/microorganisms10071438

20. The combined effects of nucleotide-binding domain-like receptor protein 3 polymorphisms and levels of blood lead on developmental delays in preschool children

Author:
Yu-Mei Hsueh; Wei-Jen Chen; Chi-Jung Chung; Ru-Lan Hsieh; Hsi-Hsien Chen; Ya-Li Huang; Horng-Sheng Shiue; Ming-I Lin; Shu-Chi Mu; Ying-Chin Lin
Source:
Journal of hazardous materials 2022 v.424 pp. 127317
ISSN:
0304-3894
Subject:
erythrocytes,   etc   ; arsenic; cadmium; confidence interval; genotype; inflammasomes; lead; odds ratio;     Show all 8 Subjects
Abstract:
... Nucleotide-binding domain-like receptors protein 3 (NLRP3) inflammasomes are associated with neuroinflammation and multiple NLRP3 genes regulate NLRP3 expression. Our study aimed to investigate the association of NLRP3 polymorphisms with developmental delay in preschool children. We also explored whether NLRP3 polymorphisms modified the effects of total urinary arsenic and blood cadmium and lead t ...
DOI:
10.1016/j.jhazmat.2021.127317