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1. From Genes to Therapy in Autism Spectrum Disorder

Author:
Jacob A. S. Vorstman; Christine M. Freitag; Antonio M. Persico
Source:
Genes 2022 v.13 no.8 pp. -
ISSN:
2073-4425
Subject:
etiology,   etc   ; autism; therapeutics;     Show all 3 Subjects
Abstract:
... In recent years, findings from genetic and other biological studies are starting to reveal the role of various molecular mechanisms that contribute to the etiology of ASD [...] ...
DOI:
10.3390/genes13081377

2. Diagnosing and treating gastric impactions in horses

Author:
Amber H Mathie; Claire Dixon
Source:
In practice 2022 v.44 no.2 pp. 100-106
ISSN:
0263-841X
Subject:
etiology,   etc   ; Equidae; horses; stomach;     Show all 4 Subjects
Abstract:
... Background: Gastric impaction is an uncommon and potentially fatal condition in equids and is defined as a persistent accumulation of dry, firm ingesta within the stomach. Left untreated these impactions can progress to gastric rupture. However, gastric impactions present with non‐specific clinical signs of varying severity, making diagnosis challenging. While often diagnosed at referral practices ...
DOI:
10.1002/inpr.177

3. The cause of cancer: The unifying theory

Author:
Marie-Ange Majérus
Source:
Advances in cancer biology 2022 v.4 pp. 100034
ISSN:
2667-3940
Subject:
etiology,   etc   ; models; ova; risk; therapeutics;     Show all 5 Subjects
Abstract:
... Nowadays, still, the exact etiology of cancer remains to be uncovered. The understanding that cancer results from uncontrolled proliferation of cells does not provide a solution to curing cancer. Although several irreconciliable theories on the cause of cancer have been proposed, none explain the overall complexity of the disease. Yet, there is the remarkable discovery that the Egg Cell’s Genetic ...
DOI:
10.1016/j.adcanc.2022.100034

4. Notes méthodologiques sur l’approche holistique des consommations alimentaires : méthodes, concepts et mise en œuvre

Author:
Emmanuelle Kesse-Guyot; Moufidath Adjibade; Mathilde Touvier; Joséphine Brunin; Benjamin Allès; Julia Baudry; Blandine de Lauzon Guillain
Source:
Cahiers de nutrition et de diététique 2022 v.57 no.4 pp. 260-269
ISSN:
0007-9960
Subject:
etiology,   etc   ; epidemiology; food groups; risk;     Show all 4 Subjects
Abstract:
... In nutritional epidemiology, the traditional approach consists of estimating the association between single food/food group or nutrient and the risk of a health event, accounting for confounding factors. New methods have been developed to look at food as a whole through holistic approaches. Initially, two types of methods have been described: a priori methods based on dietary scores and a posterio ...
DOI:
10.1016/j.cnd.2022.01.004

5. Diet and food in attention-deficit hyperactivity disorder

Author:
Klaus W. Lange; Yukiko Nakamura; Andreas Reissmann
Source:
Journal of future foods 2022 v.2 no.2 pp. 112-118
ISSN:
2772-5669
Subject:
etiology,   etc   ; lifestyle; physical activity; sucrose;     Show all 4 Subjects
Abstract:
... Deficiencies of nutrients, including vitamins, minerals and polyunsaturated fatty acids, and surpluses of food items, such as sucrose and artificial food additives, have not convincingly been shown to be involved in the etiology of ADHD. At group level, there is no conclusive evidence supporting dietary interventions for the treatment of ADHD. The identification of a role of food compounds in ADHD ...
DOI:
10.1016/j.jfutfo.2022.03.008

6. Mesenchymal stem cell-mediated transfer of mitochondria: mechanisms and functional impact

Author:
Francesca Velarde; Sarah Ezquerra; Xavier Delbruyere; Andres Caicedo; Yessia Hidalgo; Maroun Khoury
Source:
Cellular and molecular life sciences 2022 v.79 no.3 pp. 177
ISSN:
1420-682X
Subject:
etiology,   etc   ; biomedical research; mitochondria; therapeutics;     Show all 4 Subjects
Abstract:
... There is a steadily growing interest in the use of mitochondria as therapeutic agents. The use of mitochondria derived from mesenchymal stem/stromal cells (MSCs) for therapeutic purposes represents an innovative approach to treat many diseases (immune deregulation, inflammation-related disorders, wound healing, ischemic events, and aging) with an increasing amount of promising evidence, ranging fr ...
DOI:
10.1007/s00018-022-04207-3

7. A systematic review of associations between genetic polymorphism and dyslexia in the Indian population

Author:
D R Rahul; R Joseph Ponniah
Source:
Journal of biosciences 2022 v.47 no.3 pp. 41
ISSN:
0973-7138
Subject:
etiology,   etc   ; genetic polymorphism; systematic review;     Show all 3 Subjects
Abstract:
... There is growing interest in understanding the genetic mechanisms underlying dyslexia. Accordingly, the literature on dyslexia is replete with shreds of evidence linking genes and their genetic markers with dyslexia among different populations. Even though genetic inquiries into dyslexia in the Asian population has gained interest in recent years, very little is known about the genes and their pol ...
DOI:
10.1007/s12038-022-00276-5

8. Nutritional and Metabolic Imbalance in Keratoconus

Author:
Romina Mayra Lasagni Vitar; Filippo Bonelli; Paolo Rama; Giulio Ferrari
Source:
Nutrients 2022 v.14 no.4 pp. -
ISSN:
2072-6643
Subject:
etiology,   etc   ; biomechanics; cornea; metabolites; pathophysiology; vision;     Show all 6 Subjects
Abstract:
... Keratoconus (KC) is a progressive corneal degeneration characterized by structural changes consisting of progressive thinning and steepening of the cornea. These alterations result in biomechanical weakening and, clinically, in vision loss. While the etiology of KC has been the object of study for over a century, no single agent has been found. Recent reviews suggest that KC is a multifactorial di ...
DOI:
10.3390/nu14040913

9. An idiographic approach to idiopathic environmental intolerance attributed to electromagnetic fields (IEI-EMF) part I. Environmental, psychosocial and clinical assessment of three individuals with severe IEI-EMF

Author:
Zsuzsanna Dömötör; Zsuzsanna Szabolcs; Márk Bérdi; Michael Witthöft; Ferenc Köteles; Renáta Szemerszky
Source:
Heliyon 2022 v.8 no.7 pp. e09987
ISSN:
2405-8440
Subject:
etiology,   etc   ; health status; paper; psychological stress;     Show all 4 Subjects
Abstract:
... IEI-EMF refers to an environmental illness whose primary feature is the occurrence of symptoms that are attributed to exposure to weak electromagnetic fields (EMFs). There is a growing evidence that this condition is characterized by marked individual differences thus a within-subject approach might add important information beyond the widely used nomothetic method. A mixed qualitative/quantitativ ...
DOI:
10.1016/j.heliyon.2022.e09987

10. A preliminary genetic association study of GAD1 and GABAB receptor genes in patients with treatment-resistant schizophrenia

Author:
Atsuhiro Miyazawa; Nobuhisa Kanahara; Masanobu Kogure; Ikuo Otsuka; Satoshi Okazaki; Yoshinori Watanabe; Fumiaki Yamasaki; Yusuke Nakata; Yasunori Oda; Akitoyo Hishimoto; Masaomi Iyo
Source:
Molecular biology reports 2022 v.49 no.3 pp. 2015-2024
ISSN:
0301-4851
Subject:
etiology,   etc   ; cognition; females; molecular biology; schizophrenia;     Show all 5 Subjects
Abstract:
... BACKGROUND: GABAergic system dysfunction has been implicated in the etiology of schizophrenia and of cognitive impairments in particular. Patients with treatment-resistant schizophrenia (TRS) generally suffer from profound cognitive impairments in addition to severe positive symptoms, suggesting that GABA system dysfunction could be involved more closely in patients with TRS. METHODS AND RESULTS: ...
DOI:
10.1007/s11033-021-07019-z

11. lncRNA-miRNA-mRNA Network in Primary Open Angle Glaucoma (POAG): In-Silico Trial

Author:
Amirhosein Maali; Seyed Ahmad Rasoulinejad
Source:
Russian journal of genetics 2022 v.58 no.6 pp. 730-735
ISSN:
1022-7954
Subject:
etiology,   etc   ; biomarkers; computer simulation; glaucoma; microRNA;     Show all 5 Subjects
Abstract:
... Primary open-angle glaucoma (POAG) is a type of glaucoma with a normal appearance of anterior chamber angle. The molecular etiology of POAG is unknown. This study aimed to investigate the possible role of non-coding RNAs in POAG. The down-regulation patterns were observed for 2495 probs, and 5548 probs were up-regulated. These 8043 up/down-regulated probs bind to 4984 different genes. In POAG pati ...
DOI:
10.1134/S1022795422060047

12. Evaluation of cross pinning for stabilization of distal third femoral fractures in dogs

Author:
G.S.C. Bose; M. Raghunath; N.V.V. Harikrishna; N. Lakshmi Rani
Source:
Indian journal of veterinary surgery 2022 v.43 no.1 pp. 21-23
ISSN:
0973-9726
Subject:
etiology,   etc   ; bandages; body weight; femur; surgery;     Show all 5 Subjects
Abstract:
... The present study included six dogs with different age, breed, body weight and etiological factors with distal third extraarticular femoral fractures, which were stabilized using K wires by cross pinning method. Postoperatively, the limbs were externally supported by Robert Jones bandage. Complete weight bearing on the operated limb while standing and walking was seen by 10ᵗʰ postoperative day in ...
DOI:
10.5958/0973-9726.2022.00006.7

13. ARNSHL gene identification: past, present and future

Author:
Ayesha Imtiaz
Source:
Molecular genetics and genomics 2022 v.297 no.5 pp. 1185-1193
ISSN:
1617-4615
Subject:
etiology,   etc   ; deafness; genes; genomics; genotyping; homozygosity; mice;     Show all 7 Subjects
Abstract:
... Autosomal recessive non-syndromic hearing loss (ARNSHL) is the most common hereditary deafness. It is genetically highly heterogeneous and about 89 gene loci and 76 gene’s mutations have been implicated in the etiology of ARNSHL. Molecular basis of ARNSHL remains unresolved in 60% of cases and gene mutations are unknown for 23 of 89 reported loci. Techniques used to identify reported ARNSHL gene m ...
DOI:
10.1007/s00438-022-01926-x

14. Efficacy of Teduglutide for Parenteral Support Reduction in Patients with Short Bowel Syndrome: A Systematic Review and Meta-Analysis

Author:
Fabio Bioletto; Chiara D’Eusebio; Fabio Dario Merlo; Umberto Aimasso; Marta Ossola; Marianna Pellegrini; Valentina Ponzo; Alessia Chiarotto; Antonella De Francesco; Ezio Ghigo; Simona Bo
Source:
Nutrients 2022 v.14 no.4 pp. -
ISSN:
2072-6643
Subject:
etiology,   etc   ; adults; colon; meta-analysis; systematic review;     Show all 5 Subjects
Abstract:
... Teduglutide has been described as an effective treatment for parenteral support (PS) reduction in patients with short bowel syndrome (SBS). However, a quantitative summary of the available evidence is still lacking. PubMed/Medline, EMBASE, Cochrane library, OVID, and CINAHL databases were systematically searched up to July 2021 for studies reporting the rate of response (defined as a ≥20% reductio ...
DOI:
10.3390/nu14040796

15. Identification of Novel Gene Variants for Autism Spectrum Disorders in the Lebanese Population Using Whole-Exome Sequencing

Author:
Perla Gerges; Tania Bitar; Frederic Laumonnier; Sylviane Marouillat; Georges Nemer; Christian R. Andres; Walid Hleihel
Source:
Genes 2022 v.13 no.2 pp. -
ISSN:
2073-4425
Subject:
etiology,   etc   ; autism; genes; mutation; neurodevelopment; pathophysiology; Lebanon;     Show all 7 Subjects
Abstract:
... In our previous study, in which array CGH was used on 19 Lebanese ASD subjects and their parents, we identified rare copy number variants (CNVs) in 14 subjects. The five remaining subjects did not show any CNVs related to autism spectrum disorders (ASD). In the present complementary study, we applied whole-exome sequencing (WES), which allows the identification of rare genetic variations such as s ...
DOI:
10.3390/genes13020186

16. Where Do We Stand in the Behavioral Pathogenesis of Inflammatory Bowel Disease? The Western Dietary Pattern and Microbiota—A Narrative Review

Author:
Iwona Krela-Kaźmierczak; Oliwia Zakerska-Banaszak; Marzena Skrzypczak-Zielińska; Liliana Łykowska-Szuber; Aleksandra Szymczak-Tomczak; Agnieszka Zawada; Anna Maria Rychter; Alicja Ewa Ratajczak; Kinga Skoracka; Dorota Skrzypczak; Emilia Marcinkowska; Ryszard Słomski; Agnieszka Dobrowolska
Source:
Nutrients 2022 v.14 no.12 pp. -
ISSN:
2072-6643
Subject:
etiology,   etc   ; eating habits; microorganisms; pathogenesis; ulcerative colitis;     Show all 5 Subjects
Abstract:
... Despite the increasing knowledge with regard to IBD (inflammatory bowel disease), including ulcerative colitis (UC) and Crohn’s disease (CD), the etiology of these conditions is still not fully understood. Apart from immunological, environmental and nutritional factors, which have already been well documented, it is worthwhile to look at the possible impact of genetic factors, as well as the compo ...
DOI:
10.3390/nu14122520

17. Gene–Environment Correlation over Time: A Longitudinal Analysis of Polygenic Risk Scores for Schizophrenia and Major Depression in Three British Cohorts Studies

Author:
Sandra Machlitt-Northen; Robert Keers; Patricia B. Munroe; David M. Howard; Michael Pluess
Source:
Genes 2022 v.13 no.7 pp. -
ISSN:
2073-4425
Subject:
etiology,   etc   ; adulthood; childhood; longitudinal studies; mental depression; schizophrenia;     Show all 6 Subjects
Abstract:
... Research suggests that both genetic and environmental risk factors are involved in the aetiology of schizophrenia (SCZ) and major depressive disorder (MDD). Importantly, environmental and genetic risk factors are often related as evidenced in gene–environment correlation (rGE), which describes the observation that genetic and environmental factors are associated with each other. It is understood t ...
DOI:
10.3390/genes13071136

18. LncRNA functional annotation with improved false discovery rate achieved by disease associations

Author:
Yongheng Wang; Jincheng Zhai; Xianglu Wu; Enoch Appiah Adu-Gyamfi; Lingping Yang; Taihang Liu; Meijiao Wang; Yubin Ding; Feng Zhu; Yingxiong Wang; Jing Tang
Source:
Computational and Structural Biotechnology Journal 2022 v.20 pp. 322-332
ISSN:
2001-0370
Subject:
etiology,   etc   ; biotechnology; genes; journals; methodology; non-coding RNA;     Show all 6 Subjects
Abstract:
... The long non‐coding RNAs (lncRNAs) play critical roles in various biological processes and are associated with many diseases. Functional annotation of lncRNAs in diseases attracts great attention in understanding their etiology. However, the traditional co-expression-based analysis usually produces a significant number of false positive function assignments. It is thus crucial to develop a new app ...
DOI:
10.1016/j.csbj.2021.12.016

19. Additional stains and immunohistochemistry: what else can the pathologist tell us?

Author:
Simon Priestnall; Alejandro Suárez‐Bonnet
Source:
In practice 2022 v.44 no.7 pp. 385-393
ISSN:
0263-841X
Subject:
etiology,   etc   ; breads; butter; cytoplasm; eosin; histopathology; immunohistochemistry; necrosis;     Show all 8 Subjects
Abstract:
... Background: For the veterinary pathologist, the ‘bread and butter’ of our work is the tissue slide stained with haematoxylin and eosin (H&E). This has long become globally recognised as the ‘standard’ stain, with haematoxylin highlighting the nuclei of cells dark blue and eosin staining the cytoplasm pink. With experience, the pathologist can recognise and interpret many subtle changes in intensit ...
DOI:
10.1002/inpr.90

20. An idiographic approach to Idiopathic Environmental Intolerance attributed to Electromagnetic Fields (IEI-EMF) Part II. Ecological momentary assessment of three individuals with severe IEI-EMF

Author:
Zsuzsanna Dömötör; Gábor Ruzsa; György Thuróczy; Péter P. Necz; Steven Nordin; Ferenc Köteles; Renáta Szemerszky
Source:
Heliyon 2022 v.8 no.5 pp. e09421
ISSN:
2405-8440
Subject:
etiology,   etc   ; electrocardiography; emotions; radio waves; time series analysis;     Show all 5 Subjects
Abstract:
... IEI-EMF refers to a self-reported sensitivity characterized by attribution of non-specific physical symptoms to exposure to weak EMFs. The majority of empirical results do not support the existence of a causal relationship between EMF and IEI-EMF. However, this conclusion was drawn from environmental and experimental studies that are not without methodological limitations. In the current study, as ...
DOI:
10.1016/j.heliyon.2022.e09421