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You searched for: Subject "extracellular matrix" Remove constraint Subject: "extracellular matrix"
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1. Engineered strategies to enhance tumor penetration of drug-loaded nanoparticles

Author:
Mohammad Souri; M. Soltani; Farshad Moradi Kashkooli; Mohammad Kiani Shahvandi
Source:
Journal of controlled release 2022 v.341 pp. 227-246
ISSN:
0168-3659
Subject:
extracellular matrix,   etc   ; blood; nanocarriers; neoplasms;     Show all 4 Subjects
Abstract:
... Nanocarriers have been widely employed in preclinical studies and clinical trials for the delivery of anticancer drugs. The most important causes of failure in clinical translation of nanocarriers is their inefficient accumulation and penetration which arises from special characteristics of tumor microenvironment such as insufficient blood supply, dense extracellular matrix, and elevated interstit ...
DOI:
10.1016/j.jconrel.2021.11.024

2. Collagens from Marine Organisms towards Biomedical Applications

Author:
Azizur Rahman; Tiago H. Silva
Source:
Marine drugs 2022 v.20 no.3 pp. -
ISSN:
1660-3397
Subject:
extracellular matrix,   etc   ; collagen; structural proteins;     Show all 3 Subjects
Abstract:
... Collagen is the main fibrous structural protein in the extracellular matrix and connective tissue of animals [...] ...
DOI:
10.3390/md20030170

3. Reciprocal cell-ECM dynamics generate supracellular fluidity underlying spontaneous follicle patterning

Author:
Karl H. Palmquist; Sydney F. Tiemann; Farrah L. Ezzeddine; Sichen Yang; Charlotte R. Pfeifer; Anna Erzberger; Alan R. Rodrigues; Amy E. Shyer
Source:
Cell 2022 v.185 no.11 pp. 1960-1973.e11
ISSN:
0092-8674
Subject:
extracellular matrix,   etc   ; birds; collagen; dermis; embryogenesis;     Show all 5 Subjects
Abstract:
... During vertebrate embryogenesis, cell collectives engage in coordinated behavior to form tissue structures of increasing complexity. In the avian skin, assembly into follicles depends on intrinsic mechanical forces of the dermis, but how cell mechanics initiate pattern formation is not known. Here, we reconstitute the initiation of follicle patterning ex vivo using only freshly dissociated avian d ...
DOI:
10.1016/j.cell.2022.04.023

4. Hydrostatic pressure as a driver of cell and tissue morphogenesis

Author:
Mayank Chugh; Akankshi Munjal; Sean G. Megason
Source:
Seminars in cell & developmental biology 2022 v.131 pp. 134-145
ISSN:
1084-9521
Subject:
extracellular matrix,   etc   ; hydrostatic pressure; mechanochemistry; morphogenesis;     Show all 4 Subjects
Abstract:
... Morphogenesis, the process by which tissues develop into functional shapes, requires coordinated mechanical forces. Most current literature ascribes contractile forces derived from actomyosin networks as the major driver of tissue morphogenesis. Recent works from diverse species have shown that pressure derived from fluids can generate deformations necessary for tissue morphogenesis. In this revie ...
DOI:
10.1016/j.semcdb.2022.04.021

5. Biofilm formation in clinically relevant filamentous fungi: a therapeutic challenge

Author:
Maryam Roudbary; Roya Vahedi-Shahandashti; André Luis Souza dos Santos; Shahla Roudbar Mohammadi; Peyman Aslani; Cornelia Lass-Flörl; Célia F. Rodrigues
Source:
Critical reviews in microbiology 2022 v.48 no.2 pp. 197-221
ISSN:
1549-7828
Subject:
extracellular matrix,   etc   ; biofilm; immune system; therapeutics; yeasts;     Show all 5 Subjects
Abstract:
... Biofilms are highly-organized microbial communities attached to a biotic or an abiotic surface, surrounded by an extracellular matrix secreted by the biofilm-forming cells. The majority of fungal pathogens contribute to biofilm formation within tissues or biomedical devices, leading to serious and persistent infections. The clinical significance of biofilms relies on the increased resistance to co ...
DOI:
10.1080/1040841X.2021.1950121

6. Recent advances in 3D hydrogel culture systems for mesenchymal stem cell-based therapy and cell behavior regulation

Author:
Xinqiang Hu; Zengzilu Xia; Kaiyong Cai
Source:
Journal of materials chemistry B 2022 v.10 no.10 pp. 1486-1507
ISSN:
2050-7518
Subject:
extracellular matrix,   etc   ; biocompatible materials; hydrogels; medicine; therapeutics;     Show all 5 Subjects
Abstract:
... Mesenchymal stem cells (MSCs) have been increasingly recognized as a resource for disease treatment and regenerative medicine. Meanwhile, the unique chemical and physical properties of hydrogels provide innate advantages to achieve high quality MSCs on a large scale. Tremendous kinds of biomaterials have been employed to form hydrogels providing a controllable microenvironment for culturing MSCs. ...
DOI:
10.1039/d1tb02537f

7. Fibroblasts Close a Void in Free Space by a Purse-String Mechanism

Author:
Avelino Dos Santos Da Costa; Ramesh Subbiah; Seung Ja Oh; Hyuntae Jeong; Jung-Im Na; Kwideok Park; In-Suk Choi; Jennifer H. Shin
Source:
ACS applied materials & interfaces 2022 v.14 no.36 pp. 40522-40534
ISSN:
1944-8252
Subject:
extracellular matrix,   etc   ; actin; epithelium; fibroblasts; medicine; morphogenesis; myosin;     Show all 7 Subjects
Abstract:
... The mechanism by which stromal cells fill voids in injured tissue remains a fundamental question in regenerative medicine. While it is well-established that fibroblasts fill voids by depositing extracellular matrix (ECM) proteins as they migrate toward the wound site, little is known about their ability to adopt an epithelial-like purse-string behavior. To investigate fibroblast behavior during ga ...
DOI:
10.1021/acsami.2c07952

8. The interna of the rhizocephalan Peltogaster reticulata: Comparative morphology and ultrastructure

Author:
Aleksei A. Miroliubov; Anastasia D. Lianguzova; Stanislav A. Ilyutkin; Natalia A. Arbuzova; Nikita E. Lapshin; Ekaterina P. Laskova
Source:
Arthropod structure & development 2022 v.70 pp. 101190
ISSN:
1467-8039
Subject:
extracellular matrix,   etc   ; arthropods; endoparasites; integument; lifestyle; parasitism; ultrastructure;     Show all 7 Subjects
Abstract:
... Specialized morphology of diverse parasitic crustaceans reflects their adaptations to an endoparasitic lifestyle. Rhizocephalan barnacles are one of the most highly modified obligatory parasites of other crustaceans. Comprehension of the functional morphology of rhizocephalans could elucidate the main evolutionary trends not only inside parasitic barnacles, but in parasitism as a whole. Despite th ...
DOI:
10.1016/j.asd.2022.101190

9. Confocal and super-resolution imaging of polarized intracellular trafficking and secretion of basement membrane proteins during Drosophila oogenesis

Author:
Shah Hemin P.; Devergne Olivier
Source:
Journal of visualized experiments 2022 no.183 pp. e63778
ISSN:
1940-087X
Subject:
extracellular matrix,   etc   ; Drosophila; basement membrane; morphogenesis; oogenesis; secretion;     Show all 6 Subjects
Abstract:
... The basement membrane (BM) - a specialized sheet of extracellular matrix present at the basal side of epithelial cells - is critical for the establishment and maintenance of epithelial tissue morphology and organ morphogenesis. Moreover, the BM is essential for tissue modeling, serving as a signaling platform, and providing external forces to shape tissues and organs. Despite the many important ro ...
DOI:
10.3791/63778

10. Disease-specific glycosaminoglycan patterns in the extracellular matrix of human lung and brain

Author:
Maria Ennemoser; Alexandra Pum; Andreas Kungl
Source:
Carbohydrate research 2022 v.511 pp. 108480
ISSN:
0008-6215
Subject:
extracellular matrix,   etc   ; brain; cytokines; glycosaminoglycans; humans; lungs; proteoglycans; research;     Show all 8 Subjects
Abstract:
... A wide variety of diseases throughout the mammalian organism is characterized by abnormal deposition of various components of the extracellular matrix (ECM), including the heterogeneous family of glycosaminoglycans (GAGs), which contribute considerably to the ECM architecture as part of the so-called proteoglycans. The GAG's unique sulfation pattern, derived from highly dynamic and specific modifi ...
DOI:
10.1016/j.carres.2021.108480

11. Finding the sweet spot: a library of hydrogels with tunable degradation for tissue model development

Author:
Narendra Pandala; Michael A. LaScola; Zachary Hinton; La Shanda T. J. Korley; Erin Lavik
Source:
Journal of materials chemistry B 2022 v.10 no.13 pp. 2194-2203
ISSN:
2050-7518
Subject:
extracellular matrix,   etc   ; biocompatible materials; cations; drugs; endothelial cells; hydrogels;     Show all 6 Subjects
Abstract:
... In vitro models are valuable tools for applications including understanding cellular mechanisms and drug screening. Hydrogel biomaterials facilitate in vitro models by mimicking the extracellular matrix and in vivo microenvironment. However, it can be challenging for cells to form tissues in hydrogels that do not degrade. In contrast, if hydrogels degrade too much or too quickly, tissue models may ...
DOI:
10.1039/d1tb02436a

12. Fibrous Structure and Stiffness of Designer Protein Hydrogels Synergize to Regulate Endothelial Differentiation of Bone Marrow Mesenchymal Stem Cells

Author:
Kai-Kai Tian; Sheng-Chen Huang; Xiao-Xia Xia; Zhi-Gang Qian
Source:
Biomacromolecules 2022 v.23 no.4 pp. 1777-1788
ISSN:
1526-4602
Subject:
extracellular matrix,   etc   ; actin; bone marrow; cell proliferation; hydrogels; medicine;     Show all 6 Subjects
Abstract:
... Matrix stiffness and fibrous structure provided by the native extracellular matrix have been increasingly appreciated as important cues in regulating cell behaviors. Recapitulating these physical cues for cell fate regulation remains a challenge due to the inherent difficulties in making mimetic hydrogels with well-defined compositions, tunable stiffness, and structures. Here, we present two serie ...
DOI:
10.1021/acs.biomac.2c00032

13. Fungal biofilms: insights for the food industry

Author:
Alciléia CV Miranda; Graziela F Leães; Marina V Copetti
Source:
Current opinion in food science 2022 v.46 pp. 100846
ISSN:
2214-7993
Subject:
extracellular matrix,   etc   ; biofilm; enzymes; food industry; food spoilage; spoilage;     Show all 6 Subjects
Abstract:
... Microscopical fungi, both molds and yeasts, play a relevant role in the food industry. Despite having beneficial applications in the biotechnological area and being an alternative in industrial enzyme production, fungi also present a potential for food deterioration. These microorganisms are excellent candidates for biofilm formation, producing an extracellular matrix capable of conferring resista ...
DOI:
10.1016/j.cofs.2022.100846

14. Phenotypic heterogeneity, stability and plasticity in tumor‐promoting carcinoma‐associated fibroblasts

Author:
Yoshihiro Mezawa; Akira Orimo
Source:
FEBS journal 2022 v.289 no.9 pp. 2429-2447
ISSN:
1742-464X
Subject:
extracellular matrix,   etc   ; disease progression; fibroblasts; metastasis; neoplasms; phenotype; therapeutics;     Show all 7 Subjects
Abstract:
... Reciprocal interactions between cancer cells and stromal cells in the tumor microenvironment (TME) are essential for full‐blown tumor development. Carcinoma‐associated fibroblasts (CAFs) are a key component of the TME together with a wide variety of stromal cell types including vascular, inflammatory, and immune cells in the extracellular matrix. CAFs not only promote tumor growth, invasion, and m ...
DOI:
10.1111/febs.15851

15. Role of MMP-2 and CD147 in kidney fibrosis

Author:
Zhengyuan Cheng; Xiaojuan Zhang; Yu Zhang; Li Li; Pingsheng Chen
Source:
Open life sciences 2022 v.17 no.1 pp. 1182-1190
ISSN:
2391-5412
Subject:
extracellular matrix,   etc   ; endocytosis; fibrosis; gelatinase A; hypoxia; kidneys; pathophysiology;     Show all 7 Subjects
Abstract:
... Matrix metalloproteinase-2 (MMP-2) and cluster of differentiation 147 (CD147) both play important roles in the development of kidney fibrosis, and CD147 can induce the production and activation of MMP-2. In the early stage of kidney fibrosis, MMP-2 promotes extracellular matrix (ECM) production and accelerates the development of kidney fibrosis, while in the advanced stage, MMP-2 activity decrease ...
DOI:
10.1515/biol-2022-0482

16. Atomic force microscopy indentation for nanomechanical characterization of live pathological cardiovascular/heart tissue and cells

Author:
Juan C. Benech; Gerardo Romanelli
Source:
Micron 2022 v.158 pp. 103287
ISSN:
0968-4328
Subject:
extracellular matrix,   etc   ; animals; atomic force microscopy; early development; heart;     Show all 5 Subjects
Abstract:
... Cardiovascular/heart tissue and cells are subjected to dynamic forces from very early development, without pause, for the entire life of the animal or person and are characterized by being very sensitive to the mechanical properties of the surrounding tissue. Most cardiovascular diseases are characterized by important modifications that occur at the level of extracellular matrix (ECM) components t ...
DOI:
10.1016/j.micron.2022.103287

17. Elastin in healthy and diseased lung

Author:
Howard J Vindin; Brian GG Oliver; Anthony S Weiss
Source:
Current opinion in biotechnology 2022 v.74 pp. 15-20
ISSN:
0958-1669
Subject:
extracellular matrix,   etc   ; biotechnology; elastin; etiology; lungs; respiratory tract diseases;     Show all 6 Subjects
Abstract:
... Elastic fibers are an essential part of the pulmonary extracellular matrix (ECM). Intact elastin is required for normal function and its damage contributes profoundly to the etiology and pathology of lung disease. This highlights the need for novel lung-specific imaging methodology that enables high-resolution 3D visualization of the ECM. We consider elastin’s involvement in chronic respiratory di ...
DOI:
10.1016/j.copbio.2021.10.025

18. The Dual Role of Mesenchymal Stromal Cells and Their Extracellular Vesicles in Carcinogenesis

Author:
Zarema Gilazieva; Aleksei Ponomarev; Albert Rizvanov; Valeriya Solovyeva
Source:
Biology 2022 v.11 no.6 pp. -
ISSN:
2079-7737
Subject:
extracellular matrix,   etc   ; angiogenesis; apoptosis; carcinogenesis; cell cycle; neoplasm progression; neoplasms;     Show all 7 Subjects
Abstract:
... Mesenchymal stem cells (MSCs) are a major component of the tumor microenvironment (TME) and play an important role in tumor progression. MSCs remodel the extracellular matrix, participate in the epithelial–mesenchymal transition, promote the spread of metastases, and inhibit antitumor immune responses in the TME; however, there are also data pertaining to the antitumor effects of MSCs. MSCs activa ...
DOI:
10.3390/biology11060813

19. New insights into glial scar formation after spinal cord injury

Author:
Amanda Phuong Tran; Philippa Mary Warren; Jerry Silver
Source:
Cell and tissue research 2022 v.387 no.3 pp. 319-336
ISSN:
0302-766X
Subject:
extracellular matrix,   etc   ; animal injuries; astrocytes; neurons; research; sensation; stroke; therapeutics;     Show all 8 Subjects
Abstract:
... Severe spinal cord injury causes permanent loss of function and sensation throughout the body. The trauma causes a multifaceted torrent of pathophysiological processes which ultimately act to form a complex structure, permanently remodeling the cellular architecture and extracellular matrix. This structure is traditionally termed the glial/fibrotic scar. Similar cellular formations occur following ...
DOI:
10.1007/s00441-021-03477-w

20. On the way back from 3D to 2D: Chitosan promotes adhesion and development of neuronal networks onto culture supports

Author:
Donatella Di Lisa; Lorenzo Muzzi; Sara Pepe; Elena Dellacasa; Monica Frega; Anna Fassio; Sergio Martinoia; Laura Pastorino
Source:
Carbohydrate polymers 2022 v.297 pp. 120049
ISSN:
0144-8617
Subject:
extracellular matrix,   etc   ; adhesion; biopolymers; chitosan; electrophysiology; humans; neurites; rats; synaptogenesis;     Show all 9 Subjects
Abstract:
... Most in vitro functional and morphological studies for developing nervous system have been performed using traditional monolayer cultures onto supports modified by extracellular matrix components or synthetic biopolymers. These biomolecules act as adhesion factors essential for neuronal growth and differentiation. In this study, the use of chitosan as adhesion factor was investigated. Primary rat ...
DOI:
10.1016/j.carbpol.2022.120049