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1. Cytoskeleton Architecture Regulates Glycolysis Coupling Cellular Metabolism to Mechanical Cues

Author:
Fernie, Alisdair R.; Zhang, Youjun; Sampathkumar, Arun
Source:
Trends in biochemical sciences 2020 v.45 no.8 pp. 637-638
ISSN:
0968-0004
Subject:
extracellular matrix,   etc   ; actin; cell growth; cytoskeleton; glycolysis;     Show all 5 Subjects
Abstract:
... Energy-demanding processes, such as cell growth, migration, and differentiation, are tension modulated, begging the question whether metabolism and mechanical tension are tightly linked. A recent report by Park et al. shows that stiffness in the extracellular matrix (ECM) promotes reorganization of actin, resulting in enhanced glycolysis. ...
DOI:
10.1016/j.tibs.2020.04.003

2. The tissues and regulatory pattern of limb chondrogenesis

Author:
Fowler, Donald A.; Larsson, Hans C.E.
Source:
Developmental biology 2020 v.463 no.2 pp. 124-134
ISSN:
0012-1606
Subject:
extracellular matrix,   etc   ; cartilage; chondrogenesis; genes; physicochemical properties;     Show all 5 Subjects
Abstract:
... Initial limb chondrogenesis offers the first differentiated tissues that resemble the mature skeletal anatomy. It is a developmental progression of three tissues. The limb begins with undifferentiated mesenchyme—1, some of which differentiates into condensations—2, and this tissue then transforms into cartilage—3. Each tissue is identified by physical characteristics of cell density, shape, and ex ...
DOI:
10.1016/j.ydbio.2020.04.009

3. Decellularized ECM-derived bioinks: Prospects for the future

Author:
Kabirian, Fatemeh; Mozafari, Masoud
Source:
Methods 2020 v.171 pp. 108-118
ISSN:
1046-2023
Subject:
extracellular matrix,   etc   ; bioprinting; patients; tissue engineering; ultrastructure;     Show all 5 Subjects
Abstract:
... Decellularization aims to remove cells from tissue ultrastructure while preserving the mechanical and biological properties, which makes the decellularized extracellular matrix (dECM) an appropriate scaffold for tissue engineering applications. Three-dimensional (3D) bioprinting technology as a reproducible and accurate method can print the combination of ECM and autologous cells layer by layer to ...
DOI:
10.1016/j.ymeth.2019.04.019

4. Express Method for Determining the Relation between Polyethylene Biocorrosion by Chromobacterium violaceum Biofilms and Their Ability to Form Extracellular Matrix

Author:
Zhurina, M. V.; Gannesen, A. V.; Martyanov, S. V.; Plakunov, V. K.
Source:
Microbiology 2020 v.89 no.1 pp. 44-49
ISSN:
0026-2617
Subject:
extracellular matrix,   etc   ; Chromobacterium violaceum; biofilm; polyethylene;     Show all 4 Subjects
Abstract:
... An express method for measuring biocorrosion of the surface of polyethylene by mono- and multi-species microbial biofilms was developed. The method involves massive inoculation of polyethylene samples with pure microbial cultures or their mixtures, with subsequent incubation for 5‒7 days providing for the biofilm development. The damage to the surface of polyethylene was determined both by the opt ...
DOI:
10.1134/S0026261720010178

5. Correction: 3D cell printing of islet-laden pancreatic tissue-derived extracellular matrix bioink constructs for enhancing pancreatic functions

Author:
Kim, Jaewook; Shim, In Kyong; Hwang, Dong Gyu; Lee, Yu Na; Kim, Myungji; Kim, Hyeonji; Kim, Seok-Won; Lee, Song; Kim, Song Cheol; Cho, Dong-Woo; Jang, Jinah
Source:
Journal of materials chemistry B 2019 v.7 no.29 pp. 4592
ISSN:
2050-7518
Subject:
extracellular matrix,   etc   ; bioprinting; chemistry;     Show all 3 Subjects
Abstract:
... Correction for ‘3D cell printing of islet-laden pancreatic tissue-derived extracellular matrix bioink constructs for enhancing pancreatic functions’ by Jaewook Kim et al., J. Mater. Chem. B, 2019, 7, 1773–1781. ...
DOI:
10.1039/c9tb90097g

6. Natural polypeptides-based electrically conductive biomaterials for tissue engineering

Author:
Vandghanooni, Somayeh; Eskandani, Morteza
Source:
International journal of biological macromolecules 2020 v.147 pp. 706-733
ISSN:
0141-8130
Subject:
extracellular matrix,   etc   ; biocompatible materials; biopolymers; electric field; polypeptides; tissue engineering;     Show all 6 Subjects
Abstract:
... Fabrication of an appropriate scaffold is the key fundamental step required for a successful tissue engineering (TE). The artificial scaffold as extracellular matrix in TE has noticeable role in the fate of cells in terms of their attachment, proliferation, differentiation, orientation and movement. In addition, chemical and electrical stimulations affect various behaviors of cells such as polarit ...
DOI:
10.1016/j.ijbiomac.2019.12.249

7. Elastin Biomaterials in Dermal Repair

Author:
Wen, Qingyun; Mithieux, Suzanne M.; Weiss, Anthony S.
Source:
Trends in biotechnology 2020 v.38 no.3 pp. 280-291
ISSN:
0167-7799
Subject:
extracellular matrix,   etc   ; biocompatible materials; dermis; tissue repair; tropoelastin;     Show all 5 Subjects
Abstract:
... Wound healing has historically relied on endogenous processes, but engineered materials are increasingly being used to assist tissue repair. Elastin is an essential functional component of the dermal extracellular matrix and is an important part of skin wound repair that encompasses an elastic dermis. Advances in modern technology have better elucidated the specific signaling factors and cells tha ...
DOI:
10.1016/j.tibtech.2019.08.005

8. Cell traction force in a confined microenvironment with double-sided micropost arrays

Author:
Hui, Jianan; Pang, Stella W.
Source:
RSC advances 2019 v.9 no.15 pp. 8575-8584
ISSN:
2046-2069
Subject:
extracellular matrix,   etc   ; cell movement; osteoblasts;     Show all 3 Subjects
Abstract:
... Three-dimensional (3D) cell migrations are regulated by force interactions between cells and a 3D extracellular matrix (ECM). Mapping the 3D traction force generated by cells on the surrounding ECM with controlled confinement and contact area will be useful in understanding cell migration. In this study, double-sided micropost arrays were fabricated. The cell traction force was mapped by micropost ...
DOI:
10.1039/c8ra10170a

9. Nanoengineered Osteoinductive Bioink for 3D Bioprinting Bone Tissue

Author:
Chimene, David; Miller, Logan; Cross, Lauren M.; Jaiswal, Manish K.; Singh, Irtisha; Gaharwar, Akhilesh K.
Source:
ACS applied materials & interfaces 2020 v.12 no.14 pp. 15976-15988
ISSN:
1944-8252
Subject:
extracellular matrix; extracellular matrix proteins,   etc   ; bioactive compounds; biodegradability; bioprinting; bones; encapsulation; humans; manufacturing; mechanical properties; medicine; mesenchymal stromal cells; mineralization; models; sequence analysis; transcriptome; transcriptomics;     Show all 17 Subjects
Abstract:
... Bioprinting is an emerging additive manufacturing approach to the fabrication of patient-specific, implantable three-dimensional (3D) constructs for regenerative medicine. However, developing cell-compatible bioinks with high printability, structural stability, biodegradability, and bioactive characteristics is still a primary challenge for translating 3D bioprinting technology to preclinical and ...
DOI:
10.1021/acsami.9b19037

10. Recent advances in biotechnology for heparin and heparan sulfate analysis

Author:
Qiao, Meng; Lin, Lei; Xia, Ke; Li, Jun; Zhang, Xing; Linhardt, Robert J.
Source:
Talanta 2020 v.219 pp. 121270
ISSN:
0039-9140
Subject:
extracellular matrix,   etc   ; anticoagulants; biotechnology; blood; glucosamine; hemorrhage; heparan sulfate; heparin; mammals; overdose; thrombocytopenia; uronic acids;     Show all 12 Subjects
Abstract:
... Heparan sulfate (HS) is a class of linear, sulfated, anionic polysaccharides, called glycosaminoglycans (GAGs), which present on the mammalian cell surfaces and extracellular matrix. HS GAGs display a wide range of critical biological functions, particularly in cell signaling. HS is composed of repeating units of 1 → 4 glucosidically linked uronic acid and glucosamine residues. Heparin, a pharmaco ...
DOI:
10.1016/j.talanta.2020.121270

11. Interfacial reinforcement in bioceramic/biopolymer composite bone scaffold: The role of coupling agent

Author:
Shuai, Cijun; Yu, Li; Feng, Pei; Gao, Chengde; Peng, Shuping
Source:
Colloids and surfaces 2020 v.193 pp. 111083
ISSN:
0927-7765
Subject:
extracellular matrix,   etc   ; biopolymers; chemical composition; mechanical properties; minerals; moieties; reaction mechanisms; silane;     Show all 8 Subjects
Abstract:
... The combination of biopolymer and bioceramic can mimic the chemical composition of the native bone extracellular matrix which is composed of inorganic minerals and organic collagenous. However, the poor interfacial compatibility between organic biopolymer and inorganic bioceramic restricts the full development of bioceramic/biopolymer composite scaffold for bone regeneration application. Coupling ...
DOI:
10.1016/j.colsurfb.2020.111083

12. Biofilm Matrixome: Extracellular Components in Structured Microbial Communities

Author:
Karygianni, L.; Ren, Z.; Koo, H.; Thurnheer, T.
Source:
Trends in microbiology 2020 v.28 no.8 pp. 668-681
ISSN:
0966-842X
Subject:
extracellular matrix,   etc   ; biochemical compounds; biofilm; human diseases; infectious diseases; lifestyle; microbial communities; physicochemical properties; polymers; virulence;     Show all 10 Subjects
Abstract:
... Biofilms consist of microbial communities embedded in a 3D extracellular matrix. The matrix is composed of a complex array of extracellular polymeric substances (EPS) that contribute to the unique attributes of biofilm lifestyle and virulence. This ensemble of chemically and functionally diverse biomolecules is termed the ‘matrixome’. The composition and mechanisms of EPS matrix formation, and its ...
DOI:
10.1016/j.tim.2020.03.016

13. The role of flow in bacterial biofilm morphology and wetting properties

Author:
Recupido, Federica; Toscano, Giuseppe; Tatè, Rosarita; Petala, Maria; Caserta, Sergio; Karapantsios, Thodoris D.; Guido, Stefano
Source:
Colloids and surfaces 2020 v.192 pp. 111047
ISSN:
0927-7765
Subject:
extracellular matrix,   etc   ; Pseudomonas fluorescens; bacterial communities; biofilm; contact angle; glass; laminar flow; mass transfer;     Show all 8 Subjects
Abstract:
... Biofilms are bacterial communities embedded in an extracellular matrix, able to adhere to surfaces. Different experimental set-ups are widely used for in vitro biofilm cultivation; however, a well-defined comparison among different culture conditions, especially suited to interfacial characterization, is still lacking in the literature. The main objective of this work is to study the role of flow ...
DOI:
10.1016/j.colsurfb.2020.111047

14. MMPs and ADAMs/ADAMTS inhibition therapy of abdominal aortic aneurysm

Author:
Li, Yongqi; Wang, Weicheng; Li, Lei; Khalil, Raouf A.
Source:
Life sciences 2020 v.253 pp. 117659
ISSN:
0024-3205
Subject:
extracellular matrix,   etc   ; aneurysm; apoptosis; inflammation; innate immunity; metalloproteinases; mortality; myocytes; oxidative stress; smooth muscle; therapeutics;     Show all 11 Subjects
Abstract:
... Abdominal aortic aneurysm (AAA) is a chronic vascular degenerative disease featured by progressive dilation and remodeling of the vascular wall, which may lead to aortic rupture and high mortality. The occurrence and development of AAA involve multiple mechanisms, including extracellular matrix degradation, chronic inflammation, oxidative stress, apoptosis of vascular smooth muscle cells and innat ...
DOI:
10.1016/j.lfs.2020.117659

15. Effect of cell-extracellular matrix interaction on myogenic characteristics and artificial skeletal muscle tissue

Author:
Ding, Ran; Horie, Masanobu; Nagasaka, Sumire; Ohsumi, Saki; Shimizu, Kazunori; Honda, Hiroyuki; Nagamori, Eiji; Fujita, Hideaki; Kawamoto, Takuo
Source:
Journal of bioscience and bioengineering 2020 v.130 no.1 pp. 98-105
ISSN:
1389-1723
Subject:
extracellular matrix,   etc   ; biological models; cell fusion; cell movement; integrins; mice; myoblasts; myotubes; skeletal muscle;     Show all 9 Subjects
Abstract:
... Although various types of artificial skeletal muscle tissue have been reported, the contractile forces generated by tissue-engineered artificial skeletal muscles remain to be improved for biological model and clinical applications. In this study, we investigated the effects of extracellular matrix (ECM) and supplementation of a small molecule, which has been reported to enhance α7β1 integrin expre ...
DOI:
10.1016/j.jbiosc.2020.02.008

16. The role of Piezo proteins and cellular mechanosensing in tuning the fate of transplanted stem cells

Author:
Barzegari, Abolfazl; Omidi, Yadollah; Ostadrahimi, Alireza; Gueguen, Virginie; Meddahi-Pellé, Anne; Nouri, Mohammad; Pavon-Djavid, Graciela
Source:
Cell and tissue research 2020 v.381 no.1 pp. 1-12
ISSN:
0302-766X
Subject:
extracellular matrix,   etc   ; cell transplantation; forces; humans; ion channels; mechanotransduction; shear stress; stem cells;     Show all 8 Subjects
Abstract:
... Differentiation of stem cells can be modulated by a combination of internal and external signals, including mechanical cues from the surrounding microenvironment. Although numerous chemical and biological agents have been recognized in regulating stem cells’ fate, little is known about their potential to directly sense the mechanical signals to choose differentiation into a specific lineage. The s ...
DOI:
10.1007/s00441-020-03191-z

17. Bilayer pifithrin-α loaded extracellular matrix/PLGA scaffolds for enhanced vascularized bone formation

Author:
Xie, Xiaobo; Wang, Wanshun; Cheng, Jing; Liang, Haifeng; Lin, Zefeng; Zhang, Tao; Lu, Yao; Li, Qi
Source:
Colloids and surfaces 2020 v.190 pp. 110903
ISSN:
0927-7765
Subject:
extracellular matrix,   etc   ; bioactive properties; biocompatibility; bone formation; bones; composite materials; intestines; mineralization; nanofibers; tissue engineering;     Show all 10 Subjects
Abstract:
... Small intestinal submucosa extracellular matrix (SIS-ECM) composite materials are catching eyes in tissue engineering but have been rarely studied in bone repair. In this study, we developed the unique bilayer bone scaffolds by assembling decellularized SIS-ECM and poly(lactic-co-glycolic acid) (PLGA) nanofibers through the electrospinning technique. To strengthen the bioactivity of the scaffolds, ...
DOI:
10.1016/j.colsurfb.2020.110903

18. A brick in the wall: Discovering a novel mineral component of the biofilm extracellular matrix

Author:
Keren-Paz, Alona; Kolodkin-Gal, Ilana
Source:
New biotechnology 2020 v.56 pp. 9-15
ISSN:
1871-6784
Subject:
extracellular matrix,   etc   ; Bacillus subtilis; Gram-negative bacteria; Mycobacterium smegmatis; antibiotics; bacterial communities; biofilm; calcite; phylogeny; solutes;     Show all 10 Subjects
Abstract:
... Multicellular bacterial communities, known as biofilms, have been thought to be held together solely by a self-produced organic extracellular matrix (ECM). However, new evidence for a missed mineral constituent of ECM in both Gram-positive and Gram-negative bacterial species, is accumulating. Study of two phylogenetically distinct bacteria, Bacillus subtilis and Mycobacterium smegmatis, identified ...
DOI:
10.1016/j.nbt.2019.11.002

19. ATDC5 cells as a model of cartilage extracellular matrix neosynthesis, maturation and assembly

Author:
Wilhelm, Dafné; Kempf, Hervé; Bianchi, Arnaud; Vincourt, Jean-Baptiste
Source:
Journal of proteomics 2020 v.219 pp. 103718
ISSN:
1874-3919
Subject:
extracellular matrix,   etc   ; biosynthesis; cartilage; cell lines; chondrogenesis; collagen; models; post-translational modification; proteome;     Show all 9 Subjects
Abstract:
... Fibrillar collagens and proteoglycans (PGs) are quantitatively the major constituents of extracellular matrices (ECM). They carry numerous crucial post-translational modifications (PTMs) that tune the resulting biomechanical properties of the corresponding tissues. The mechanisms determining these PTMs remain largely unknown, notably because available established cell lines do not recapitulate muc ...
DOI:
10.1016/j.jprot.2020.103718

20. Hyaluronic acid: A review on its biology, aspects of drug delivery, route of administrations and a special emphasis on its approved marketed products and recent clinical studies

Author:
Vasvani, Shyam; Kulkarni, Pratik; Rawtani, Deepak
Source:
International journal of biological macromolecules 2020 v.151 pp. 1012-1029
ISSN:
0141-8130
Subject:
extracellular matrix,   etc   ; biocompatibility; biodegradability; clinical trials; drugs; encapsulation; gels; hyaluronic acid; mucoadhesion; nanocarriers; polymers; tissue repair;     Show all 12 Subjects
Abstract:
... Hyaluronic acid (HA) is a large non-sulphated glycosaminoglycan that is an important component of extracellular matrix (ECM) and a biodegradable polymer. Due to a variation in its molecular weight, HA derivatives can be utilized to make different formulations like fillers, creams, gels and drops. HA based drug research has seen a recent surge largely due to some properties like mucoadhesion, bioco ...
DOI:
10.1016/j.ijbiomac.2019.11.066