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1. Cell traction force in a confined microenvironment with double-sided micropost arrays

Author:
Hui, Jianan; Pang, Stella W.
Source:
RSC advances 2019 v.9 no.15 pp. 8575-8584
ISSN:
2046-2069
Subject:
extracellular matrix,   etc   ; cell movement; osteoblasts;     Show all 3 Subjects
Abstract:
... Three-dimensional (3D) cell migrations are regulated by force interactions between cells and a 3D extracellular matrix (ECM). Mapping the 3D traction force generated by cells on the surrounding ECM with controlled confinement and contact area will be useful in understanding cell migration. In this study, double-sided micropost arrays were fabricated. The cell traction force was mapped by micropost ...
DOI:
10.1039/c8ra10170a

2. Organization of the lophophore in the deep-sea brachiopod Pelagodiscus atlanticus and evolution of the lophophore in the Brachiozoa

Author:
Kuzmina, Tatyana V.; Temereva, Elena N.
Source:
Organisms, diversity, & evolution 2019 v.19 no.1 pp. 31-39
ISSN:
1439-6092
Subject:
extracellular matrix,   etc   ; evolution; histology; micro-computed tomography;     Show all 4 Subjects
Abstract:
... Molecular data indicate that brachiopods and phoronids form a clade Brachiozoa. In both groups, the lophophore consists of a brachial axis that bears a row of tentacles and does take different forms. Pelagodiscus atlanticus is a brachiopod with an unusual lophophore combining primitive (horseshoe-shaped brachial axis) and advanced (brachial axis forms two arms that are raised freely into the mantl ...
DOI:
10.1007/s13127-018-0388-0

3. Hyaluronan fragments produced during tissue injury: A signal amplifying the inflammatory response

Author:
Avenoso, Angela; Bruschetta, Giuseppe; D'Ascola, Angela; Scuruchi, Michele; Mandraffino, Giuseppe; Gullace, Rosa; Saitta, Antonino; Campo, Salvatore; Campo, Giuseppe M.
Source:
Archives of biochemistry and biophysics 2019 v.663 pp. 228-238
ISSN:
0003-9861
Subject:
extracellular matrix,   etc   ; depolymerization; homeostasis; hyaluronic acid; inflammation; molecular weight;     Show all 6 Subjects
Abstract:
... Inflammation is a complex mechanism that plays a key role during diseases. Dynamic features of the extracellular matrix (ECM), in particular, during phases of tissue inflammation, have long been appreciated, and a great deal of several investigations has focused on the effects of ECM derivatives on cell function. It has been well defined that during inflammatory and tissue injury, ECM components w ...
DOI:
10.1016/j.abb.2019.01.015

4. A nano-fibrous platform of copolymer patterned surfaces for controlled cell alignment

Author:
Zhang, Kai; Arranja, Alexandra; Chen, Hongyu; Mytnyk, Serhii; Wang, Yiming; Oldenhof, Sander; van Esch, Jan H.; Mendes, Eduardo
Source:
RSC advances 2018 v.8 no.39 pp. 21777-21785
ISSN:
2046-2069
Subject:
extracellular matrix,   etc   ; composite polymers; micelles; tissue engineering;     Show all 4 Subjects
Abstract:
... The last decade has witnessed great progress in understanding and manipulating self-assembly of block copolymers in solution. A wide variety of micellar structures can be created and many promising applications in bioscience have been reported. In particular, nano-fibrous micelles provide a great platform to mimic the filamentous structure of native extracellular matrix (ECM). However, the evaluat ...
DOI:
10.1039/c8ra03527j

5. Expression of hLAMP‐1‐Positive Particles During Early Heart Development in the Chick

Author:
Abd‐Elhamid, T. H.; Conway, M. L.; Sinning, A. R.
Source:
Anatomia, histologia, embryologia 2017 v.46 no.5 pp. 413-422
ISSN:
0340-2096
Subject:
extracellular matrix,   etc   ; antibodies; chicks; heart;     Show all 4 Subjects
Abstract:
... Heart development requires coordinated activity of various factors, the disturbance of which can lead to congenital heart defects. Heart lectin‐associated matrix protein‐1 (hLAMP‐1) is a matrix protein expressed within Hensen's node at Hamburger–Hamilton (HH) stage 4, in the lateral mesoderm by HH stages 5–6 and enhanced within the left pre‐cardiac field at HH stage 7. At HH stages 15–16, hLAMP‐1 ...
DOI:
10.1111/ahe.12283

6. Cuticle itself as a central and dynamic player in shaping cuticle

Author:
Tajiri, Reiko
Source:
Current opinion in insect science 2017 v.19 pp. 30-35
ISSN:
2214-5745
Subject:
extracellular matrix,   etc   ; exoskeleton; insects; morphogenesis;     Show all 4 Subjects
Abstract:
... The wide variety of external morphologies has underlain the evolutionary success of insects. The insect exoskeleton, or cuticle, which covers the entire body and constitutes the external morphology, is extracellular matrix produced by the epidermis. How is cuticle shaped during development? Past studies have mainly focused on patterning, differentiation and morphogenesis of the epidermis. Recently ...
DOI:
10.1016/j.cois.2016.10.009

7. Granular hydrogels: emergent properties of jammed hydrogel microparticles and their applications in tissue repair and regeneration

Author:
Riley, Lindsay; Schirmer, Lucas; Segura, Tatiana
Source:
Current opinion in biotechnology 2019 v.60 pp. 1-8
ISSN:
0958-1669
Subject:
extracellular matrix,   etc   ; cell culture; humans; hydrogels; medicine; microparticles; porous media; tissue repair;     Show all 8 Subjects
Abstract:
... Granular hydrogels are emerging as a versatile and effective platform for tissue engineered constructs in regenerative medicine. The hydrogel microparticles (HMPs) that compose these materials exhibit particle jamming above a minimum packing fraction, which results in a bulk, yet dynamic, granular hydrogel scaffold. These injectable, microporous scaffolds possess self-assembling, shear-thinning, a ...
DOI:
10.1016/j.copbio.2018.11.001

8. Fgf- and Bmp-signaling regulate gill regeneration in Ambystoma mexicanum

Author:
Saito, Nanami; Nishimura, Koki; Makanae, Aki; Satoh, Akira
Source:
Developmental biology 2019 v.452 no.2 pp. 104-113
ISSN:
0012-1606
Subject:
extracellular matrix,   etc   ; Ambystoma mexicanum; amphibians; appendages; axons; ganglia; genes; gills; head; nerve tissue; phenotype; tail;     Show all 12 Subjects
Abstract:
... Gill regeneration has not been well studied compared to regeneration of other appendages, such as limb and tail regeneration. Here, we focused on axolotl gill regeneration and found that Fgf- and Bmp-signaling are involved in their gill regeneration mechanism. Axolotls have three pairs of gill rami, and each gill ramus has multiple gill filaments. The gills consist of mesenchyme rich in extracellu ...
DOI:
10.1016/j.ydbio.2019.04.011

9. Micro and ultrastructural changes monitoring during decellularization for the generation of a biocompatible liver

Author:
Ahmed, Ebtehal; Saleh, Tarek; Yu, Lina; Kwak, Ho-Hyun; Kim, Byeong-Moo; Park, Kyung-Mee; Lee, Yun-Suk; Kang, Byung-Jae; Choi, Ki-Young; Kang, Kyung-Sun; Woo, Heung Myong
Source:
Journal of bioscience and bioengineering 2019 v.128 no.2 pp. 218-225
ISSN:
1389-1723
Subject:
extracellular matrix,   etc   ; deoxyribonucleases; detergents; liver; monitoring; octoxynol; proteins; sodium dodecyl sulfate; trypsin; ultrastructure;     Show all 10 Subjects
Abstract:
... Decellularization of a whole organ is an attractive process that has been used to create 3D scaffolds structurally and micro-architecturally similar to the native one. Currently used decellularization protocols exhibit disrupted extracellular matrix (ECM) structure and denatured ECM proteins. Therefore, maintaining a balance between ECM preservation and cellular removal is a major challenge. The a ...
DOI:
10.1016/j.jbiosc.2019.02.007

10. MMP targeting in the battle for vision: Recent developments and future prospects in the treatment of diabetic retinopathy

Author:
Drankowska, Justyna; Kos, Michał; Kościuk, Andrzej; Marzęda, Paweł; Boguszewska-Czubara, Anna; Tylus, Magdalena; Święch-Zubilewicz, Anna
Source:
Life sciences 2019 v.229 pp. 149-156
ISSN:
0024-3205
Subject:
extracellular matrix,   etc   ; Alzheimer disease; atherosclerosis; blindness; diabetic retinopathy; disease course; enzyme inhibitors; metalloproteinases; neoplasms; therapeutics; vision;     Show all 11 Subjects
Abstract:
... Matrix metalloproteinases (MMPs) are enzymes capable of degrading nearly all types of extracellular matrix. They perform a wide range of roles in physiological processes, which is the reason for their strict regulation by numerous mechanisms including natural tissue inhibitors of metalloproteinases (TIMP). Research only started to shed light on more troublesome aspects of MMPs function, like cance ...
DOI:
10.1016/j.lfs.2019.05.038

11. Filopodia and focal adhesions: An integrated system driving branching morphogenesis in neuronal pathfinding and angiogenesis

Author:
Fischer, Robert S.; Lam, Pui-Ying; Huttenlocher, Anna; Waterman, Clare M.
Source:
Developmental biology 2019 v.451 no.1 pp. 86-95
ISSN:
0012-1606
Subject:
extracellular matrix,   etc   ; Danio rerio; actin; angiogenesis; focal adhesions; models; morphogenesis; neurites; organelles; pseudopodia; sprouting; vertebrates;     Show all 12 Subjects
Abstract:
... Single cell branching during development in vertebrates is typified by neuronal branching to form neurites and vascular branches formed by sprouting angiogenesis. Neurons and endothelial tip cells possess subcellular protrusions that share many common features from the morphological to the molecular level. Both systems utilize filopodia as their cellular protrusion organelles and depend on specifi ...
DOI:
10.1016/j.ydbio.2018.08.015

12. Tuning surface functionalization and collagen gel thickness to regulate cancer cell migration

Author:
Unnikandam Veettil, Shalini R.; Van Bruggen, Shawn M.; Hwang, Doh-Gyu; Bartlett, Michael D.; Schneider, Ian C.
Source:
Colloids and surfaces 2019 v.179 pp. 37-47
ISSN:
0927-7765
Subject:
extracellular matrix,   etc   ; cell movement; collagen; gels; modulus of elasticity; neoplasm cells; neoplasms;     Show all 7 Subjects
Abstract:
... Cancer cells have a tremendous ability to sense and respond to extracellular matrix (ECM) stiffness, modulating invasion. The magnitude of the sensed stiffness can either promote or inhibit the migration of cancer cells out of the primary tumor into surrounding tissue. Work has been done on examining the role of stiffness in tuning cancer cell migration by controlling elastic modulus in the bulk. ...
DOI:
10.1016/j.colsurfb.2019.03.031

13. Unique arrangement of bone matrix orthogonal to osteoblast alignment controlled by Tspan11-mediated focal adhesion assembly

Author:
Nakanishi, Yohei; Matsugaki, Aira; Kawahara, Kosuke; Ninomiya, Takafumi; Sawada, Hiroshi; Nakano, Takayoshi
Source:
Biomaterials 2019 v.209 pp. 103-110
ISSN:
0142-9612
Subject:
extracellular matrix,   etc   ; apatite; collagen; focal adhesions; gene expression regulation; integrins; isotropy; microarray technology; osteoblasts;     Show all 9 Subjects
Abstract:
... During tissue construction, cells coordinate extracellular matrix (ECM) assembly depending on the cellular arrangement. The traditional understanding of the relationship between the ECM and cells is limited to the orientation-matched interaction between them. Indeed, it is commonly accepted that the bone matrix (collagen/apatite) is formed along osteoblast orientation. Nonetheless, our recent find ...
DOI:
10.1016/j.biomaterials.2019.04.016

14. A 3D cell printed muscle construct with tissue-derived bioink for the treatment of volumetric muscle loss

Author:
Choi, Yeong-Jin; Jun, Young-Joon; Kim, Dong Yeon; Yi, Hee-Gyeong; Chae, Su-Hun; Kang, Junsu; Lee, Juyong; Gao, Ge; Kong, Jeong-Sik; Jang, Jinah; Chung, Wan Kyun; Rhie, Jong-Won; Cho, Dong-Woo
Source:
Biomaterials 2019 v.206 pp. 160-169
ISSN:
0142-9612
Subject:
extracellular matrix,   etc   ; animal models; biomimetics; bioprinting; cell viability; hypoxia; innervation; muscles;     Show all 8 Subjects
Abstract:
... Volumetric muscle loss (VML) is an irrecoverable injury associated with muscle loss greater than 20%. Although hydrogel-based 3D engineered muscles and the decellularized extracellular matrix (dECM) have been considered for VML treatment, they have shown limited efficacy. We established a novel VML treatment with dECM bioink using 3D cell printing technology. Volumetric muscle constructs composed ...
DOI:
10.1016/j.biomaterials.2019.03.036

15. In vitro and in vivo evaluation of an electrospun-aligned microfibrous implant for Annulus fibrosus repair

Author:
Gluais, Maude; Clouet, Johann; Fusellier, Marion; Decante, Cyrille; Moraru, Constantin; Dutilleul, Maeva; Veziers, Joëlle; Lesoeur, Julie; Dumas, Dominique; Abadie, Jérôme; Hamel, Antoine; Bord, Eric; Chew, Sing Yian; Guicheux, Jérôme; Le Visage, Catherine
Source:
Biomaterials 2019 v.205 pp. 81-93
ISSN:
0142-9612
Subject:
extracellular matrix,   etc   ; animal models; biodegradability; biomimetics; collagen; delamination; immunohistochemistry; in vivo studies; pain; sheep;     Show all 10 Subjects
Abstract:
... Annulus fibrosus (AF) impairment is associated with reherniation, discogenic pain, and disc degeneration after surgical partial discectomy. Due to a limited intrinsic healing capacity, defects in the AF persist over time and it is hence necessary to adopt an appropriate strategy to close and repair the damaged AF. In this study, a cell-free biodegradable scaffold made of polycaprolactone (PCL), el ...
DOI:
10.1016/j.biomaterials.2019.03.010

16. Phosphorylation mapping of Laminin β1-chain: Kinases in association with active sites

Author:
Verrou, Kleio-Maria; Galliou, Panagiota Angeliki; Papaioannou, Maria; Koliakos, Georgios
Source:
Journal of biosciences 2019 v.44 no.2 pp. 55
ISSN:
0250-5991
Subject:
extracellular matrix,   etc   ; active sites; cAMP-dependent protein kinase; cell adhesion; humans; laminin; phosphorylation; protein kinase C;     Show all 8 Subjects
Abstract:
... Laminins are a major constituent of the extracellular matrix (ECM). Laminin-111, the most extensively studied laminin isoform, consists of the α1, the β1 and the γ1 chain, and is involved in many cellular processes, like adhesion, migration and differentiation. Given the regulatory role of phosphorylation in protein function, it is important to identify the phosphorylation sites of human laminin β ...
DOI:
10.1007/s12038-019-9871-9

17. The 3′UTR of the α6 integrin message regulates localization of α6β4 integrin heterodimers

Author:
Woychek, Alexandra; Kligys, Kristina; Hopkinson, Susan B.; Jones, Jonathan C.R.
Source:
Biochemical and biophysical research communications 2019 v.513 no.1 pp. 8-14
ISSN:
0006-291X
Subject:
extracellular matrix,   etc   ; 3' untranslated regions; Adenoviridae; adhesion; cell lines; epithelial cells; humans; integrins; keratinocytes; lungs;     Show all 10 Subjects
Abstract:
... The α6β4 integrin heterodimer is an essential component of hemidesmosomes (HDs) and HD-related structures, which adhere epithelial cells to the underlying extracellular matrix. In this study, we focused on the importance of the α6 integrin 3′ untranslated region (UTR) in α6β4 integrin localization. To do so, A549 cells (a type II lung alveolar cell line) and immortalized human epidermal keratinocy ...
DOI:
10.1016/j.bbrc.2019.03.116

18. Fabrication and characterization of collagen-heparin-polypyrrole composite conductive film for neural scaffold

Author:
Su, Dandan; Zhou, Juan; Ahmed, Kamel S.; Ma, Qiaoqiao; Lv, Guozhong; Chen, Jinghua
Source:
International journal of biological macromolecules 2019 v.129 pp. 895-903
ISSN:
0141-8130
Subject:
extracellular matrix,   etc   ; biocompatibility; catalytic activity; collagen; crosslinking; electrical properties; heparin; hydrogen bonding; nerve regeneration; neurons; pyrroles;     Show all 11 Subjects
Abstract:
... In this work, a conductive film consisted of polypyrrole-heparin-collagen (PHC film) was fabricated as a potential neural scaffold. Heparin was initially modified with pyrrole, which was further polymerized with pyrrole monomer under the catalysis of ferric trichloride. Then collagen was added and crosslinked through amide bond, as well as physical interaction with pyrrole through hydrogen bond. I ...
DOI:
10.1016/j.ijbiomac.2019.02.087

19. Relaxin and extracellular matrix remodeling: Mechanisms and signaling pathways

Author:
Ng, Hooi Hooi; Shen, Matthew; Samuel, Chrishan S.; Schlossmann, Jens; Bennett, Robert G.
Source:
Molecular and cellular endocrinology 2019 v.487 pp. 59-65
ISSN:
0303-7207
Subject:
extracellular matrix,   etc   ; agonists; collagen; fibrosis; inflammation; peptide receptors; relaxin; signal transduction;     Show all 8 Subjects
Abstract:
... Fibrosis is associated with accumulation of excess fibrillar collagen, leading to tissue dysfunction. Numerous processes, including inflammation, myofibroblast activation, and endothelial-to-mesenchymal transition, play a role in the establishment and progression of fibrosis. Relaxin is a peptide hormone with well-known antifibrotic properties that result from its action on numerous cellular targe ...
DOI:
10.1016/j.mce.2019.01.015

20. Electroconductive materials as biomimetic platforms for tissue regeneration

Author:
Hosoyama, Katsuhiro; Ahumada, Manuel; Goel, Keshav; Ruel, Marc; Suuronen, Erik J.; Alarcon, Emilio I.
Source:
Biotechnology advances 2019 v.37 no.3 pp. 444-458
ISSN:
0734-9750
Subject:
extracellular matrix,   etc   ; biocompatible materials; biomimetics; cell proliferation; muscles; neurons; tissue repair; tissues;     Show all 8 Subjects
Abstract:
... In many diseases, tissue regeneration is compromised and/or insufficient to restore tissue/organ function. Therefore, novel regenerative therapies are being developed to enhance resident and transplanted cell proliferation and functional differentiation. Numerous biomaterials engineered to include nanocomponents have emerged as promising candidates to fulfil the need of mimicking the properties of ...
DOI:
10.1016/j.biotechadv.2019.02.011