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You searched for: Subject "fibroblasts" Remove constraint Subject: "fibroblasts"
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1. Topical systems for the controlled release of antineoplastic Drugs: Oxidized Alginate-Gelatin Hydrogel/Unilamellar vesicles

Author:
Soledad Stagnoli; Cintia Garro; Ozlem Ertekin; Susanne Heid; Stefan Seyferth; Gastón Soria; N. Mariano Correa; Aldo Leal-Egaña; Aldo R. Boccaccini
Source:
Journal of colloid and interface science 2023 v.629 pp. 1066-1080
ISSN:
0021-9797
Subject:
fibroblasts,   etc   ; adenocarcinoma; biocompatibility; curcumin; cytotoxicity; drug carriers; drugs; epithelial cells; freeze drying; humans; hydrogels; melanoma; oxidation; rats; topical application; water solubility;     Show all 16 Subjects
Abstract:
... The efficacy of chemotherapeutic procedures relies on delivering proper concentrations of anti-cancer drugs in the tumor surroundings, so as to prevent potential side effects on healthy tissues. Novel drug carrier platforms should not just be able to deliver anticancer molecules, but also allow for adjustements in the way these drugs are administered to the patients. We developed a system for deli ...
DOI:
10.1016/j.jcis.2022.08.163

2. Neutralization of interleukin-11 attenuates silica particles-induced pulmonary inflammation and fibrosis in vivo

Author:
Jixuan Ma; Yujia Xie; Yiju Xu; Pei Gu; Yingdie Zhang; Lieyang Fan; Yun Zhou; Haijiao Wang; Ting Zhou; Jintong He; Dongming Wang; Weihong Chen
Source:
Journal of environmental sciences (China) 2023 v.126 pp. 772-783
ISSN:
1001-0742
Subject:
fibroblasts,   etc   ; antibodies; collagen; environmental exposure; epithelium; fibrosis; gelatinase A; glycoproteins; inflammation; interleukin-11; interleukin-6; lungs; mice; mitogen-activated protein kinase; necrosis; neoplasms; neutralization; silica; therapeutics; China;     Show all 20 Subjects
Abstract:
... Environmental exposure to crystalline silica particles can lead to silicosis, which is one of the most serious pulmonary interstitial fibrosis around the world. Unfortunately, the exact mechanism on silicosis is unclear, and the effective treatments are lacking to date. In this study, we aim to explore the molecular mechanism by which interleukin-11 (IL-11) affects silica particles-induced lung in ...
DOI:
10.1016/j.jes.2022.03.015

3. An Improved Method to Generate Human Induced Astrocytes

Author:
Janelle Drouin-Ouellet
Source:
Cellular reprogramming 2022 v.24 no.4 pp. 163-164
ISSN:
2152-4998
Subject:
fibroblasts,   etc   ; astrocytes; humans;     Show all 3 Subjects
Abstract:
... A major improvement in the generation of astrocytes directly from human fibroblasts will now facilitate the study of how aging impacts on astrocyte function and whether this contributes to neurodegenerative disorders. ...
DOI:
10.1089/cell.2022.0076

4. Two Sets of Compound Complex Driving for High Efficiency of Nonintegration Reprogramming of Human Fibroblasts

Author:
Xiangyi Lin; Cuiping Rong; Shouhai Wu
Source:
Cellular reprogramming 2022 v.24 no.2 pp. 71-79
ISSN:
2152-4998
Subject:
fibroblasts,   etc   ; humans; mice;     Show all 3 Subjects
Abstract:
... Currently, plentiful chemical-assisted methods have been applied for mouse induced pluripotent stem cells (iPSCs). It has been reported that small-molecule compounds can only reprogram mouse embryonic fibroblasts into mouse chemically induced pluripotent stem cells (mouse CiPSCs). However, human CiPSCs have not been reported. Therefore, it is still necessary to search for safer chemically assisted ...
DOI:
10.1089/cell.2021.0143

5. Visualizing scar development using scad assay - an Ex-situ skin scarring assay

Author:
Ramesh Pushkar; Ye Haifeng; Dasgupta Bikram; Machens Hans-Günther; Rinkevich Yuval
Source:
Journal of visualized experiments 2022 no.182 pp. e63808
ISSN:
1940-087X
Subject:
fibroblasts,   etc   ; fascia; mice;     Show all 3 Subjects
Abstract:
... The mammalian global response to sealing deep tissue wounds is through scar formation and tissue contraction, mediated by specialized fascia fibroblasts. Despite the clinical significance of scar formation and impaired wound healing, our understanding of fascia fibroblast dynamics in wound healing is cursory due to the lack of relevant assays that enable direct visualization of fibroblast choreogr ...
DOI:
10.3791/63808

6. Developmental analysis of reconstructed embryos of second‐generation cloned transgenic goats

Author:
Shaozheng Song; Rui Lu; Yong Cheng; Ting Zhang; Leying Gu; Kangying Yu; Mingming Zhou; Dan Li
Source:
Reproduction in domestic animals 2022 v.57 no.5 pp. 473-480
ISSN:
0936-6768
Subject:
fibroblasts,   etc   ; pregnancy rate; somatic cells;     Show all 3 Subjects
Abstract:
... To improve the efficiency of the production of transgenic cloned goats by somatic cell nuclear transfer (SCNT), the development of reconstructed embryos of first‐generation (G1) and second‐generation (G2) cloned transgenic goats was compared and analysed. Primary transgenic foetal fibroblasts were used as donor cells for G1 somatic cell nuclear transfer (SCNT). When the G1 transgenic embryos devel ...
DOI:
10.1111/rda.14083

7. Defective perlecan-associated basement membrane regeneration and altered modulation of transforming growth factor beta in corneal fibrosis

Author:
Steven E. Wilson
Source:
Cellular and molecular life sciences 2022 v.79 no.3 pp. 144
ISSN:
1420-682X
Subject:
fibroblasts,   etc   ; basement membrane; collagen; cornea; fibrosis;     Show all 5 Subjects
Abstract:
... In the cornea, the epithelial basement membrane (EBM) and corneal endothelial Descemet’s basement membrane (DBM) critically regulate the localization, availability and, therefore, the functions of transforming growth factor (TGF)β1, TGFβ2, and platelet-derived growth factors (PDGF) that modulate myofibroblast development. Defective regeneration of the EBM, and notably diminished perlecan incorpora ...
DOI:
10.1007/s00018-022-04184-7

8. Evaluation of wet nanocellulose membranes produced by different bacterial strains for healing full-thickness skin defects

Author:
Haibin Yuan; Lin Chen; Feng F. Hong
Source:
Carbohydrate polymers 2022 v.285 pp. 119218
ISSN:
0144-8617
Subject:
fibroblasts,   etc   ; biocompatibility; biocompatible materials; cellulose; experimental design;     Show all 5 Subjects
Abstract:
... Bacterial nanocellulose (BNC) is an excellent candidate biomaterial for wound dressing applications, although its preparation should consider the differences in wound healing resulting from BNC biosynthesized by different bacterial strains. This study design aimed to characterize the BNC produced by three different bacterial strains and compare their effectiveness for wound healing applications. T ...
DOI:
10.1016/j.carbpol.2022.119218

9. Neurovascular signals in amyotrophic lateral sclerosis

Author:
Stefano Sorrentino; Alessandro Polini; Valentina Arima; Alessandro Romano; Angelo Quattrini; Giuseppe Gigli; Pamela Mozetic; Lorenzo Moroni
Source:
Current opinion in biotechnology 2022 v.74 pp. 75-83
ISSN:
0958-1669
Subject:
fibroblasts,   etc   ; amyotrophic lateral sclerosis; biotechnology; homeostasis; neurons; pathogenesis;     Show all 6 Subjects
Abstract:
... The neurovascular system (NVS) is a complex anatomic-functional unit that synergically works to maintain organs/tissues homeostasis of the entire body. NVS alterations have recently emerged as a common distinct feature in the pathogenesis of several neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). Despite their undeniable involvement, neurovascular signalling pathways rem ...
DOI:
10.1016/j.copbio.2021.10.021

10. Recent developments in antibacterial or antibiofilm compound coating for biliary stents

Author:
Tao Wu; Yan Yang; He Su; Yuanhui Gu; Quanming Ma; Yan Zhang
Source:
Colloids and surfaces 2022 v.219 pp. 112837
ISSN:
0927-7765
Subject:
fibroblasts,   etc   ; antibacterial properties; biodegradability; cholestasis; three-dimensional printing;     Show all 5 Subjects
Abstract:
... Cholestasis of the indwelling biliary stents usually leads to stone recurrence after endoscopic retrograde cholangio pancreatoraphy (ERCP). Biliary stents, including metallic and none-degradable plastic stents are widely used in clinical settings due to their many excellent properties. However, conventional biliary stents still suffer from poor antibacterial activity and anti-bile-adhesion, which ...
DOI:
10.1016/j.colsurfb.2022.112837

11. Specific locations and amounts of denatured collagen and collagen-specific chaperone HSP47 in the oviducts and uteri of old cows as compared with those of heifers

Author:
Raihana Nasrin Ferdousy; Hiroya Kadokawa
Source:
Reproduction, fertility, and development 2022 v.34 no.8 pp. 619-632
ISSN:
1031-3613
Subject:
fibroblasts,   etc   ; collagen; fibrosis; fluorescence; heat shock proteins; immunohistochemistry;     Show all 6 Subjects
Abstract:
... Collagen, the most abundant extra-cellular matrix in oviducts and uteri, performs critical roles in pregnancies. We hypothesised that the locations and amounts of both denatured collagen and the collagen-specific molecular chaperone 47-kDa heat shock protein (HSP47) in the oviducts and uteri of old cows are different compared with those of young heifers because of repeated pregnancies. Since detec ...
DOI:
10.1071/RD21130

12. Fibroblasts Close a Void in Free Space by a Purse-String Mechanism

Author:
Avelino Dos Santos Da Costa; Ramesh Subbiah; Seung Ja Oh; Hyuntae Jeong; Jung-Im Na; Kwideok Park; In-Suk Choi; Jennifer H. Shin
Source:
ACS applied materials & interfaces 2022 v.14 no.36 pp. 40522-40534
ISSN:
1944-8252
Subject:
fibroblasts,   etc   ; actin; epithelium; extracellular matrix; medicine; morphogenesis; myosin;     Show all 7 Subjects
Abstract:
... The mechanism by which stromal cells fill voids in injured tissue remains a fundamental question in regenerative medicine. While it is well-established that fibroblasts fill voids by depositing extracellular matrix (ECM) proteins as they migrate toward the wound site, little is known about their ability to adopt an epithelial-like purse-string behavior. To investigate fibroblast behavior during ga ...
DOI:
10.1021/acsami.2c07952

13. Spatiotemporal Activation of Protein O-GlcNAcylation in Living Cells

Author:
Jiahui He; Zhiya Fan; Yinping Tian; Weiwei Yang; Yichao Zhou; Qiang Zhu; Wanjun Zhang; Weijie Qin; Wen Yi
Source:
Journal of the American Chemical Society 2022 v.144 no.10 pp. 4289-4293
ISSN:
1520-5126
Subject:
fibroblasts,   etc   ; N-acetylglucosamine; cell physiology; cytosol; glycoproteins; lysine; proteomics;     Show all 7 Subjects
Abstract:
... O-linked N-acetylglucosamine (O-GlcNAc) is a prevalent protein modification that plays fundamental roles in both cell physiology and pathology. O-GlcNAc is catalyzed solely by O-GlcNAc transferase (OGT). The study of protein O-GlcNAc function is limited by the lack of tools to control OGT activity with spatiotemporal resolution in cells. Here, we report light control of OGT activity in cells by re ...
DOI:
10.1021/jacs.1c11041

14. A graphene-Ag based near-infrared defined accurate anti-scarring strategy for ocular glaucoma surgery

Author:
Yanan Wang; Zikang Xu; Wenchi Li; Wei Wei; Mengqi Qin; Qun Li; Xuexia Liu; Xu Zhang; Xiaolei Wang
Source:
Biomaterials science 2022 v.10 no.5 pp. 1281-1291
ISSN:
2047-4849
Subject:
fibroblasts,   etc   ; biocompatibility; biocompatible materials; fibrosis; filtration; glaucoma; irradiation; surgery;     Show all 8 Subjects
Abstract:
... Excessive fibrosis is the major factor in the failure of glaucoma filtration surgery. So far, the dominant approach for inhibiting fibrosis is the use of an antimetabolite drug, but the complications it causes, such as filtering bleb leakage, bacterial endophthalmitis and ocular hypotony, are also inevitable. Herein, a multifunctional anti-scarring platform (PVA@rGO-Ag/5-Fu) integrated with outsta ...
DOI:
10.1039/d1bm01614h

15. Isolation of Nannocystis species from Iran and exploring their natural products

Author:
Azam Moradi; Mohammad Yaghoubi-Avini; Joachim Wink
Source:
Archives of microbiology 2022 v.204 no.2 pp. 123
ISSN:
0302-8933
Subject:
fibroblasts,   etc   ; cell lines; cytotoxicity; new species; secondary metabolites; Iran;     Show all 6 Subjects
Abstract:
... Several different techniques were employed for the isolation of Nannocystis from various sources. A polyphasic approach was used for identification. Twelve strains of N. pusilla, N. exedens, and N. konarekensis with distinctive distribution between climates were identified. The bioactivity was examined against a panel of eight bacteria, two yeasts, and one fungus; cytotoxicity was tested on the L9 ...
DOI:
10.1007/s00203-021-02738-0

16. Phenotypic heterogeneity, stability and plasticity in tumor‐promoting carcinoma‐associated fibroblasts

Author:
Yoshihiro Mezawa; Akira Orimo
Source:
FEBS journal 2022 v.289 no.9 pp. 2429-2447
ISSN:
1742-464X
Subject:
fibroblasts,   etc   ; disease progression; extracellular matrix; metastasis; neoplasms; phenotype; therapeutics;     Show all 7 Subjects
Abstract:
... Reciprocal interactions between cancer cells and stromal cells in the tumor microenvironment (TME) are essential for full‐blown tumor development. Carcinoma‐associated fibroblasts (CAFs) are a key component of the TME together with a wide variety of stromal cell types including vascular, inflammatory, and immune cells in the extracellular matrix. CAFs not only promote tumor growth, invasion, and m ...
DOI:
10.1111/febs.15851

17. Thiolated hyaluronic acid/silk fibroin dual-network hydrogel incorporated with bioglass nanoparticles for wound healing

Author:
Yifeng Yu; Bin Yang; Danlei Tian; Jiaoyan Liu; Aixi Yu; Ying Wan
Source:
Carbohydrate polymers 2022 v.288 pp. 119334
ISSN:
0144-8617
Subject:
fibroblasts,   etc   ; cell culture; fibroins; glass; hyaluronic acid; hydrogels; mice;     Show all 7 Subjects
Abstract:
... Thiolated hyaluronic acid(THA) conjugates were synthesized and the selected THA was combined with silk fibroin(SF) and bioactive glass nanoparticles to build a novel type of composite hydrogel with dual-network structure. The optimally achieved gels showed greatly enhanced strength and stiffness compared to the gels built from either THA or SF while having well-defined elasticity and injectability ...
DOI:
10.1016/j.carbpol.2022.119334

18. Bovine collagen oligopeptides accelerate wound healing by promoting fibroblast migration via PI3K/Akt/mTOR signaling pathway

Author:
Lei Bao; Xiaxia Cai; Mingyuan Zhang; Yang Xiao; Jin Jin; Tong Qin; Yong Li
Source:
Journal of functional foods 2022 v.90 pp. 104981
ISSN:
1756-4646
Subject:
fibroblasts,   etc   ; apoptosis; cattle; collagen; hydroxyproline; metabolism; models; oligopeptides; prealbumin;     Show all 9 Subjects
Abstract:
... Bovine collagen oligopeptides (BCOP) are small molecule oligopeptides isolated from bovine collagen, which have been proved to modulate the collagen metabolism. However, the effects of BCOP on wound healing is rarely known by public. This study aims to evaluate the beneficial effects of BCOP on wound healing by using an excisional wound model established in mice. Moreover, the role of the PI3K/Akt ...
DOI:
10.1016/j.jff.2022.104981

19. Continuous live cell imaging using dark field microscopy

Author:
Yang Zeng; Rui Cao; Jie Zhu; Wei Zhao; Dan Sun; Ce Zhang
Source:
Analytical methods 2022 v.14 no.16 pp. 1634-1637
ISSN:
1759-9679
Subject:
fibroblasts,   etc   ; fluorescence microscopy; fluorescent dyes; hepatoma; light intensity; phototoxicity;     Show all 6 Subjects
Abstract:
... The optical observation of live cell behavior is critical for biological and biomedical studies. The development of techniques for long-term cell and tissue imaging is, however, hindered by phototoxicity induced by excited fluorophores. We, herein, propose a methodology to capture live cell behavior using dark field microscopy (DM). Since the light intensity of DM is merely ∼0.1% of bright-field m ...
DOI:
10.1039/d2ay00043a

20. Design and characterization of fibroblast activation protein targeted pan-cancer imaging agent for fluorescence-guided surgery of solid tumors

Author:
Ramesh Mukkamala; Spencer D. Lindeman; Kate A. Kragness; Imrul Shahriar; Madduri Srinivasarao; Philip S. Low
Source:
Journal of materials chemistry B 2022 v.10 no.12 pp. 2038-2046
ISSN:
2050-7518
Subject:
fibroblasts,   etc   ; chemistry; fluorescence; fluorescent dyes; humans; neoplasms; patients; surgery;     Show all 8 Subjects
Abstract:
... Tumor-targeted fluorescent dyes have been shown to significantly improve a surgeon's ability to locate and resect occult malignant lesions, thereby enhancing a patient's chances of long term survival. Although several tumor-targeted fluorescent dyes have been developed for imaging specific subsets of human cancers, no tumor-targeted dye has been designed that can image all cancer types. Based on o ...
DOI:
10.1039/d1tb02651h