U.S. flag

An official website of the United States government

PubAg

Main content area

You searched for: Subject "gene expression" Remove constraint Subject: "gene expression"
Start Over

Search

122,692  Search Results

« Previous | 1 - 20 of 122,692 |
Number of results to display per page

Search Results

1. Soft repression: Subtle transcriptional regulation with global impact

Author:
Mitra, Anindita; Raicu, Ana‐Maria; Hickey, Stephanie L.; Pile, Lori A.; Arnosti, David N.
Source:
BioEssays 2021 v.43 no.2 pp. e2000231
ISSN:
0265-9247
Subject:
gene expression; gene expression regulation,   etc   ; transcription (genetics);     Show all 3 Subject
Abstract:
... Pleiotropically acting eukaryotic corepressors such as retinoblastoma and SIN3 have been found to physically interact with many widely expressed “housekeeping” genes. Evidence suggests that their roles at these loci are not to provide binary on/off switches, as is observed at many highly cell‐type specific genes, but rather to serve as governors, directly modulating expression within certain bound ...
DOI:
10.1002/bies.202000231

2. scDesign2: a transparent simulator that generates high-fidelity single-cell gene expression count data with gene correlations captured

Author:
Sun, Tianyi; Song, Dongyuan; Li, Wei Vivian; Li, Jingyi Jessica
Source:
Genome biology 2021 v.22 no.1 pp. 163
ISSN:
1474-760X
Subject:
gene expression,   etc   ; genes; transcriptomics;     Show all 3 Subjects
Abstract:
... A pressing challenge in single-cell transcriptomics is to benchmark experimental protocols and computational methods. A solution is to use computational simulators, but existing simulators cannot simultaneously achieve three goals: preserving genes, capturing gene correlations, and generating any number of cells with varying sequencing depths. To fill this gap, we propose scDesign2, a transparent ...
DOI:
10.1186/s13059-021-02367-2

3. The miRISC component AGO2 has multiple binding sites for Nup358 SUMO-interacting motif

Author:
Deshmukh, Prachi; Markande, Shubha; Fandade, Vikas; Ramtirtha, Yogendra; Madhusudhan, Mallur Srivatsan; Joseph, Jomon
Source:
Biochemical and biophysical research communications 2021 v.556 pp. 45-52
ISSN:
0006-291X
Subject:
gene expression,   etc   ; microRNA; research;     Show all 3 Subjects
Abstract:
... Micro-RNA mediated suppression of mRNA translation represents a major regulatory mode of post-transcriptional gene expression. Recently, the nucleoporin Nup358 was shown to interact with AGO protein, a key component of miRNA-induced silencing complex (miRISC), and facilitate the coupling of miRISC with target mRNA. Previous results suggested that SUMO-interacting motifs (SIMs) present on Nup358 me ...
DOI:
10.1016/j.bbrc.2021.03.140

4. Bioelectric signaling: Reprogrammable circuits underlying embryogenesis, regeneration, and cancer

Author:
Levin, Michael
Source:
Cell 2021 v.184 no.8 pp. 1971-1989
ISSN:
0092-8674
Subject:
gene expression,   etc   ; embryogenesis; medicine;     Show all 3 Subjects
Abstract:
... How are individual cell behaviors coordinated toward invariant large-scale anatomical outcomes in development and regeneration despite unpredictable perturbations? Endogenous distributions of membrane potentials, produced by ion channels and gap junctions, are present across all tissues. These bioelectrical networks process morphogenetic information that controls gene expression, enabling cell col ...
DOI:
10.1016/j.cell.2021.02.034

5. AUF1, an mRNA decay factor, has a discordant role in Cpeb1 expression

Author:
Oe, Souichi; Koike, Taro; Hirahara, Yukie; Tanaka, Susumu; Hayashi, Shinichi; Nakano, Yosuke; Kase, Masahiko; Noda, Yasuko; Yamada, Hisao; Kitada, Masaaki
Source:
Biochemical and biophysical research communications 2021 v.534 pp. 491-497
ISSN:
0006-291X
Subject:
gene expression,   etc   ; plasmids; research;     Show all 3 Subjects
Abstract:
... Cytoplasmic polyadenylation element binding protein 1 (CPEB1) regulates polyadenylation and subsequent translation of CPE-containing mRNAs involved in various physiological and pathological phenomena. Although the significance of CPEB1-mediated translational regulation has recently been reported, the detailed regulatory mechanism of Cpeb1 expression remains unclear. To elucidate the post-transcrip ...
DOI:
10.1016/j.bbrc.2020.11.054

6. Schema: metric learning enables interpretable synthesis of heterogeneous single-cell modalities

Author:
Singh, Rohit; Hie, Brian L.; Narayan, Ashwin; Berger, Bonnie
Source:
Genome biology 2021 v.22 no.1 pp. 131
ISSN:
1474-760X
Subject:
gene expression; gene expression regulation,   etc   ; chromatin; genome; peptides; selection pressure;     Show all 6 Subjects
Abstract:
... A complete understanding of biological processes requires synthesizing information across heterogeneous modalities, such as age, disease status, or gene expression. Technological advances in single-cell profiling have enabled researchers to assay multiple modalities simultaneously. We present Schema, which uses a principled metric learning strategy that identifies informative features in a modalit ...
DOI:
10.1186/s13059-021-02313-2

7. Analysis of differential gene expression by SRAP-cDNA in mantle tissue of Meretrix petechialis with different external shell color

Author:
Zheng, Junhong; Nie, Hongtao; Yan, Xiwu
Source:
Animal biotechnology 2021 v.32 no.1 pp. 31-37
ISSN:
1532-2378
Subject:
gene expression; gene expression regulation,   etc   ; Meretrix; animals; biotechnology; color; genome;     Show all 7 Subjects
Abstract:
... Gene expression of two shell colors in Meretrix petechialis were analyzed by sequence related amplified polymorphism-cDNA to screen the associated molecular markers. The two shell color genomes of M. petechialis were amplified using combinations of 30 primers; 11 pairs of primers showed differential fragments, and by recovery, cloning and sequencing, 18 different differential sequences were obtain ...
DOI:
10.1080/10495398.2019.1642907

8. Recent advances in tuning the expression and regulation of genes for constructing microbial cell factories

Author:
Jung, Seung-Woon; Yeom, Jinho; Park, Jong Seong; Yoo, Seung Min
Source:
Biotechnology advances 2021 v.50 pp. 107767
ISSN:
0734-9750
Subject:
gene expression,   etc   ; biotechnology; genes; genomics;     Show all 4 Subjects
Abstract:
... To overcome environmental problems caused by the use of fossil resources, microbial cell factories have become a promising technique for the sustainable and eco-friendly development of valuable products from renewable resources. Constructing microbial cell factories with high titers, yields, and productivity requires a balance between growth and production; to this end, tuning gene expression and ...
DOI:
10.1016/j.biotechadv.2021.107767

9. GAGA factor: a multifunctional pioneering chromatin protein

Author:
Chetverina, Darya; Erokhin, Maksim; Schedl, Paul
Source:
Cellular and molecular life sciences 2021 v.78 no.9 pp. 4125-4141
ISSN:
1420-682X
Subject:
gene expression,   etc   ; Drosophila; mitosis; nucleosomes;     Show all 4 Subjects
Abstract:
... The Drosophila GAGA factor (GAF) is a multifunctional protein implicated in nucleosome organization and remodeling, activation and repression of gene expression, long distance enhancer–promoter communication, higher order chromosome structure, and mitosis. This broad range of activities poses questions about how a single protein can perform so many seemingly different and unrelated functions. Curr ...
DOI:
10.1007/s00018-021-03776-z

10. ZmSPL10/14/26 are required for epidermal hair cell fate specification on maize leaf

Author:
Kong, Dexin; Pan, Xuan; Jing, Yifeng; Zhao, Yongping; Duan, Yaping; Yang, Juan; Wang, Baobao; Liu, Yuting; Shen, Rongxin; Cao, Yingying; Wu, Hong; Wei, Hongbin; Wang, Haiyang
Source:
Thenew phytologist 2021 v.230 no.4 pp. 1533-1549
ISSN:
0028-646X
Subject:
gene expression,   etc   ; corn; homeotic genes;     Show all 3 Subjects
Abstract:
... The epidermal hair and stomata are two types of specialized structures on the surface of plant leaves. On mature maize leaves, stomatal complexes and three types of hairs are distributed in a stereotyped pattern on the adaxial epidermis. However, the spatiotemporal relationship between epidermal hair and stomata development and the regulatory mechanisms governing their formation in maize remain la ...
DOI:
10.1111/nph.17293

11. Optimal control of false discovery criteria in the two‐group model

Author:
Heller, Ruth; Rosset, Saharon
Source:
Journal of the Royal Statistical Society 2021 v.83 no.1 pp. 133-155
ISSN:
1369-7412
Subject:
gene expression,   etc   ; algorithms; models; probability;     Show all 4 Subjects
Abstract:
... The highly influential two‐group model in testing a large number of statistical hypotheses assumes that the test statistics are drawn independently from a mixture of a high probability null distribution and a low probability alternative. Optimal control of the marginal false discovery rate (mFDR), in the sense that it provides maximal power (expected true discoveries) subject to mFDR control, is k ...
DOI:
10.1111/rssb.12403

12. Statistical methods for mediation analysis in the era of high-throughput genomics: Current successes and future challenges

Author:
Zeng, Ping; Shao, Zhonghe; Zhou, Xiang
Source:
Computational and Structural Biotechnology Journal 2021 v.19 pp. 3209-3224
ISSN:
2001-0370
Subject:
gene expression,   etc   ; biotechnology; genomics; methylation;     Show all 4 Subjects
Abstract:
... Mediation analysis investigates the intermediate mechanism through which an exposure exerts its influence on the outcome of interest. Mediation analysis is becoming increasingly popular in high-throughput genomics studies where a common goal is to identify molecular-level traits, such as gene expression or methylation, which actively mediate the genetic or environmental effects on the outcome. Med ...
DOI:
10.1016/j.csbj.2021.05.042

13. Caviunin glycoside (CAFG) from Dalbergia sissoo attenuates osteoarthritis by modulating chondrogenic and matrix regulating proteins

Author:
Kothari, Priyanka; Tripathi, Ashish Kumar; Girme, Aboli; Rai, Divya; Singh, Ruchi; Sinha, Shradha; Choudhary, Dharmendra; Nagar, Geet Kumar; Maurya, Rakesh; Hingorani, Lal; Trivedi, Ritu
Source:
Journal of ethnopharmacology 2022 v.282 pp. 114315
ISSN:
0378-8741
Subject:
gene expression,   etc   ; Dalbergia sissoo; active ingredients; analgesics; apoptosis; blood serum; bone resorption; cartilage; chondrocytes; glycosides; inflammation; isoflavonoids; medicinal plants; micro-computed tomography; models; osteoarthritis; proteoglycans; therapeutics; toluidine blue; traditional medicine;     Show all 20 Subjects
Abstract:
... Dalbergia sissoo DC. (Indian rosewood or Sheesham) is a traditional medicinal plant, reported since time immemorial for its analgesic, anti-nociceptive, anti-inflammatory, and immuno-modulatory properties. D. sissoo DC (DS). is being used traditionally to cure joint inflammation and joint pain.To study the potential of DS leaves and its derived novel compound CAFG to treat the clinical symptoms of ...
DOI:
10.1016/j.jep.2021.114315

14. A benchmark for RNA-seq deconvolution analysis under dynamic testing environments

Author:
Jin, Haijing; Liu, Zhandong
Source:
Genome biology 2021 v.22 no.1 pp. 102
ISSN:
1474-760X
Subject:
gene expression,   etc   ; genome; sequence analysis; simulation models;     Show all 4 Subjects
Abstract:
... BACKGROUND: Deconvolution analyses have been widely used to track compositional alterations of cell types in gene expression data. Although a large number of novel methods have been developed, due to a lack of understanding of the effects of modeling assumptions and tuning parameters, it is challenging for researchers to select an optimal deconvolution method suitable for the targeted biological c ...
DOI:
10.1186/s13059-021-02290-6

15. In vivo nuclear RNA structurome reveals RNA-structure regulation of mRNA processing in plants

Author:
Liu, Zhenshan; Liu, Qi; Yang, Xiaofei; Zhang, Yueying; Norris, Matthew; Chen, Xiaoxi; Cheema, Jitender; Zhang, Huakun; Ding, Yiliang
Source:
Genome biology 2021 v.22 no.1 pp. 11
ISSN:
1474-760X
Subject:
gene expression,   etc   ; Arabidopsis; acylation; genome; landscapes;     Show all 5 Subjects
Abstract:
... BACKGROUND: mRNA processing is critical for gene expression. A challenge in regulating mRNA processing is how to recognize the actual mRNA processing sites, such as splice and polyadenylation sites, when the sequence content is insufficient for this purpose. Previous studies suggested that RNA structure affects mRNA processing. However, the regulatory role of RNA structure in mRNA processing remai ...
DOI:
10.1186/s13059-020-02236-4

16. Combining single-molecule sequencing and next-generation sequencing to provide insight into the complex response of Iris halophila Pall. to Pb exposure

Author:
Liu, Qingquan; Zhang, Yongxia; Wang, Yinjie; Gu, Chunsun; Huang, Suzhen; Dhankher, Om Parkash; Yuan, Haiyan
Source:
Industrial crops and products 2021 v.168 pp. 113623
ISSN:
0926-6690
Subject:
gene expression regulation,   etc   ; databases; metabolism; phytoremediation; transcriptome;     Show all 5 Subjects
Abstract:
... Iris halophila Pall., a Pb accumulator with high ecological and industrial values, has enormous application potential for the phytoremediation of Pb-contaminated soil. However, the lack of full-length transcriptome information obstructs understanding of the molecular regulatory network of I. halophila response to Pb. To construct the full-length transcript database and identify the molecular mecha ...
DOI:
10.1016/j.indcrop.2021.113623

17. Non-coding RNAs role in intracranial aneurysm: General principles with focus on inflammation

Author:
Rikhtegar, Reza; Mosimann, Pascal J.; Rothaupt, Jan; Mirza-Aghazadeh-Attari, Mohammad; Hallaj, Shahin; Yousefi, Mehdi; Amiri, Atefeh; Farashi, Ebrahim; Kheyrollahiyan, Atefeh; Dolati, Sanam
Source:
Life sciences 2021 v.278 pp. 119617
ISSN:
0024-3205
Subject:
gene expression,   etc   ; aneurysm; brain; inflammation; pathogenesis; pathophysiology;     Show all 6 Subjects
Abstract:
... Intracranial aneurysm (IA) is one of the most challenging vascular lesions in the brain for clinicians. It was reported that 1%–6% of the world's population is affected by IAs. Owing to serious complications arising from these lesions, much attention has been paid to better understand their pathophysiology. Non-coding RNAs including short non-coding RNAs and long non-coding RNAs, have critical rol ...
DOI:
10.1016/j.lfs.2021.119617

18. Alternatively spliced isoforms of AUF1 regulate a miRNA–mRNA interaction differentially through their YGG motif

Author:
Sänger, Lennart; Bender, Julian; Rostowski, Katja; Golbik, Ralph; Lilie, Hauke; Schmidt, Carla; Behrens, Sven-Erik; Friedrich, Susann
Source:
RNA biology 2021 v.18 no.6 pp. 843-853
ISSN:
1555-8584
Subject:
gene expression,   etc   ; alternative splicing; hybridization; microRNA;     Show all 4 Subjects
Abstract:
... Proper base-pairing of a miRNA with its target mRNA is a key step in miRNA-mediated mRNA repression. RNA remodelling by RNA-binding proteins (RBPs) can improve access of miRNAs to their target mRNAs. The largest isoform p45 of the RBP AUF1 has previously been shown to remodel viral or AU-rich RNA elements. Here, we show that AUF1 is capable of directly promoting the binding of the miRNA let-7b to ...
DOI:
10.1080/15476286.2020.1822637

19. miR-302 family, miR-145 and miR-296 temporal expression profile along the cell cycle of human pluripotent stem cells

Author:
Rodríguez-Varela, María Soledad; Mucci, Sofía; Videla-Richardson, Guillermo Agustín; Isaja, Luciana; Sevlever, Gustavo Emilio; Scassa, María Elida; Romorini, Leonardo
Source:
Gene expression patterns 2021 v.40 pp. 119168
ISSN:
1567-133X
Subject:
gene expression,   etc   ; gene ontology; humans; interphase; microRNA;     Show all 5 Subjects
Abstract:
... Human pluripotent stem cells (hPSCs), like embryonic (hESCs) and induced pluripotent stem cells (hiPSCs), exhibit an unusual cell cycle structure characterized by a short G1 phase and cells being most of time in S phase. hPSCs are receptive to differentiation cues during their transition through G1 phase when lineage determination is decided. Although several MicroRNAs (miRNAs) have been shown to ...
DOI:
10.1016/j.gep.2021.119168

20. One stem cell program to rule them all?

Author:
Wiggans, Mallory; Pearson, Bret J.
Source:
TheFEBS journal 2021 v.288 no.11 pp. 3394-3406
ISSN:
1742-464X
Subject:
gene expression,   etc   ; evolution; genes; genomics; stem cells;     Show all 5 Subjects
Abstract:
... Many species of animals have stem cells that they maintain throughout their lives, which suggests that stem cells are an ancestral feature of all animals. From this, we take the viewpoint that cells with the biological properties of ‘stemness’—self‐renewal and multipotency—may share ancestral genetic circuitry. However, in practice is it very difficult to identify and compare stemness gene signatu ...
DOI:
10.1111/febs.15598