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1. ZmSPL10/14/26 are required for epidermal hair cell fate specification on maize leaf

Author:
Kong, Dexin; Pan, Xuan; Jing, Yifeng; Zhao, Yongping; Duan, Yaping; Yang, Juan; Wang, Baobao; Liu, Yuting; Shen, Rongxin; Cao, Yingying; Wu, Hong; Wei, Hongbin; Wang, Haiyang
Source:
Thenew phytologist 2021 v.230 no.4 pp. 1533-1549
ISSN:
0028-646X
Subject:
gene expression; homeotic genes,   etc   ; corn;     Show all 3 Subject
Abstract:
... The epidermal hair and stomata are two types of specialized structures on the surface of plant leaves. On mature maize leaves, stomatal complexes and three types of hairs are distributed in a stereotyped pattern on the adaxial epidermis. However, the spatiotemporal relationship between epidermal hair and stomata development and the regulatory mechanisms governing their formation in maize remain la ...
DOI:
10.1111/nph.17293

2. Special Issue “Genetic Advances in Neuromuscular Disorders: From Gene Identification to Gene Therapy”

Author:
Arechavala-Gomeza, Virginia; Gonzalez-Quereda, Lidia
Source:
Genes 2021 v.12 no.2
ISSN:
2073-4425
Subject:
gene therapy; genes,   etc   ; muscular dystrophy;     Show all 3 Subject
Abstract:
... Since the gene responsible for Duchenne muscular dystrophy was first described in 1987 [...] ...
DOI:
10.3390/genes12020242

3. miR-302 family, miR-145 and miR-296 temporal expression profile along the cell cycle of human pluripotent stem cells

Author:
Rodríguez-Varela, María Soledad; Mucci, Sofía; Videla-Richardson, Guillermo Agustín; Isaja, Luciana; Sevlever, Gustavo Emilio; Scassa, María Elida; Romorini, Leonardo
Source:
Gene expression patterns 2021 v.40 pp. 119168
ISSN:
1567-133X
Subject:
gene expression; gene ontology,   etc   ; humans; interphase; microRNA;     Show all 5 Subjects
Abstract:
... Human pluripotent stem cells (hPSCs), like embryonic (hESCs) and induced pluripotent stem cells (hiPSCs), exhibit an unusual cell cycle structure characterized by a short G1 phase and cells being most of time in S phase. hPSCs are receptive to differentiation cues during their transition through G1 phase when lineage determination is decided. Although several MicroRNAs (miRNAs) have been shown to ...
DOI:
10.1016/j.gep.2021.119168

4. Cationic lipids for gene delivery: many players, one goal

Author:
Ponti, Federica; Campolungo, Matilde; Melchiori, Clara; Bono, Nina; Candiani, Gabriele
Source:
Chemistry and physics of lipids 2021 v.235 pp. 105032
ISSN:
0009-3084
Subject:
gene expression; genes,   etc   ; hydrophobicity; lipids; physics; transfection;     Show all 6 Subjects
Abstract:
... Lipid-based carriers represent the most widely used alternative to viral vectors for gene expression and gene silencing purposes. This class of non-viral vectors is particularly attractive for their ease of synthesis and chemical modifications to endow them with desirable properties. Despite combinatorial approaches have led to the generation of a large number of cationic lipids displaying differe ...
DOI:
10.1016/j.chemphyslip.2020.105032

5. Pluripotent stem cell-based gene therapy approach: human de novo synthesized chromosomes

Author:
Sinenko, Sergey A.; Ponomartsev, Sergey V.; Tomilin, Alexey N.
Source:
Cellular and molecular life sciences 2021 v.78 no.4 pp. 1207-1220
ISSN:
1420-682X
Subject:
gene therapy; genes,   etc   ; genetic disorders; humans;     Show all 4 Subjects
Abstract:
... A novel approach in gene therapy was introduced 20 years ago since artificial non-integrative chromosome-based vectors containing gene loci size inserts were engineered. To date, different human artificial chromosomes (HAC) were generated with the use of de novo construction or “top-down” engineering approaches. The HAC-based therapeutic approach includes ex vivo gene transferring and correction o ...
DOI:
10.1007/s00018-020-03653-1

6. Soft repression: Subtle transcriptional regulation with global impact

Author:
Mitra, Anindita; Raicu, Ana‐Maria; Hickey, Stephanie L.; Pile, Lori A.; Arnosti, David N.
Source:
BioEssays 2021 v.43 no.2 pp. e2000231
ISSN:
0265-9247
Subject:
gene expression; gene expression regulation,   etc   ; transcription (genetics);     Show all 3 Subject
Abstract:
... Pleiotropically acting eukaryotic corepressors such as retinoblastoma and SIN3 have been found to physically interact with many widely expressed “housekeeping” genes. Evidence suggests that their roles at these loci are not to provide binary on/off switches, as is observed at many highly cell‐type specific genes, but rather to serve as governors, directly modulating expression within certain bound ...
DOI:
10.1002/bies.202000231

7. The functional characteristics of optogenetic gene therapy for vision restoration

Author:
Lindner, Moritz; Gilhooley, Michael J.; Peirson, Stuart N.; Hughes, Steven; Hankins, Mark W.
Source:
Cellular and molecular life sciences 2021 v.78 no.4 pp. 1597-1613
ISSN:
1420-682X
Subject:
gene therapy; genes,   etc   ; mice; optogenetics; vision;     Show all 5 Subjects
Abstract:
... Optogenetic strategies to restore vision in patients blind from end-stage retinal degenerations aim to render remaining retinal neurons light-sensitive. We present an innovative combination of multi-electrode array recordings together with a complex pattern-generating light source as a toolset to determine the extent to which neural retinal responses to complex light stimuli can be restored follow ...
DOI:
10.1007/s00018-020-03597-6

8. Early cis-regulatory events in the formation of retinal horizontal cells

Author:
Schick, Estie; Gonzalez, Kevin C.; Dutta, Pooja; Hossain, Kazi; Ghinia Tegla, Miruna G.; Emerson, Mark M.
Source:
Developmental biology 2021 v.476 pp. 88-100
ISSN:
0012-1606
Subject:
genes,   etc   ; interneurons; retina;     Show all 3 Subjects
Abstract:
... During retinal development, multipotent and restricted progenitor cells generate all of the neuronal cells of the retina. Among these are horizontal cells, which are interneurons that modulate the light-induced signal from photoreceptors. This study utilizes the identification of novel cis-regulatory elements as a method to examine the gene regulatory networks that direct the development of horizo ...
DOI:
10.1016/j.ydbio.2021.03.016

9. Rapid strain-specific identification of two Lactobacillus rhamnosus strains using PCR based on gene family analysis

Author:
Zhang, Chenchen; Yu, Xingtong; Wang, Dai; Gui, Ya; Wang, Chunlei; Li, Qiming; Wang, Jiaqi; Yin, Boxing; Pan, Zhiming; Gu, Ruixia
Source:
Lebensmittel-Wissenschaft + [i.e. und] Technologie 2021 v.146 pp. 111395
ISSN:
0023-6438
Subject:
genes,   etc   ; Lactobacillus rhamnosus; probiotics;     Show all 3 Subjects
Abstract:
... Because the probiotic and growth characteristics of probiotics are strain-specific features, it is crucial to be able to distinguish the probiotic strains from the other strains in the same species. To rapidly identify Lactobacillus rhamnosus at the strain level through PCR, a method for searching for several strain-specific sequences in the genome of a strain was investigated. The whole genomes o ...
DOI:
10.1016/j.lwt.2021.111395

10. The miRISC component AGO2 has multiple binding sites for Nup358 SUMO-interacting motif

Author:
Deshmukh, Prachi; Markande, Shubha; Fandade, Vikas; Ramtirtha, Yogendra; Madhusudhan, Mallur Srivatsan; Joseph, Jomon
Source:
Biochemical and biophysical research communications 2021 v.556 pp. 45-52
ISSN:
0006-291X
Subject:
gene expression,   etc   ; microRNA; research;     Show all 3 Subjects
Abstract:
... Micro-RNA mediated suppression of mRNA translation represents a major regulatory mode of post-transcriptional gene expression. Recently, the nucleoporin Nup358 was shown to interact with AGO protein, a key component of miRNA-induced silencing complex (miRISC), and facilitate the coupling of miRISC with target mRNA. Previous results suggested that SUMO-interacting motifs (SIMs) present on Nup358 me ...
DOI:
10.1016/j.bbrc.2021.03.140

11. Hes1 oscillation frequency correlates with activation of neural stem cells

Author:
Kaise, Takashi; Kageyama, Ryoichiro
Source:
Gene expression patterns 2021 v.40 pp. 119170
ISSN:
1567-133X
Subject:
genes,   etc   ; neurons; repressor proteins;     Show all 3 Subjects
Abstract:
... Quiescent neural stem cells (NSCs) are occasionally activated to undergo proliferation and subsequent neuronal differentiation. It was previously shown that the transcriptional repressor Hes1 is involved in both active and quiescent states of NSCs: when Hes1 expression oscillates, it periodically represses the proneural gene Ascl1, thereby driving Ascl1 oscillations, which regulate the active stat ...
DOI:
10.1016/j.gep.2021.119170

12. Molecular mechanisms involved in functional macroevolution of plant transcription factors

Author:
Romani, Facundo; Moreno, Javier E.
Source:
Thenew phytologist 2021 v.230 no.4 pp. 1345-1353
ISSN:
0028-646X
Subject:
genes,   etc   ; evolution; transcription (genetics);     Show all 3 Subjects
Abstract:
... Transcription factors (TFs) are key components of the transcriptional regulation machinery. In plants, they accompanied the evolution from unicellular aquatic algae to complex flowering plants that dominate the land environment. The adaptations of the body plan and physiological responses required changes in the biological functions of TFs. Some ancestral gene regulatory networks are highly conser ...
DOI:
10.1111/nph.17161

13. Bioelectric signaling: Reprogrammable circuits underlying embryogenesis, regeneration, and cancer

Author:
Levin, Michael
Source:
Cell 2021 v.184 no.8 pp. 1971-1989
ISSN:
0092-8674
Subject:
gene expression,   etc   ; embryogenesis; medicine;     Show all 3 Subjects
Abstract:
... How are individual cell behaviors coordinated toward invariant large-scale anatomical outcomes in development and regeneration despite unpredictable perturbations? Endogenous distributions of membrane potentials, produced by ion channels and gap junctions, are present across all tissues. These bioelectrical networks process morphogenetic information that controls gene expression, enabling cell col ...
DOI:
10.1016/j.cell.2021.02.034

14. Programming DNA cascade circuits on live cell membranes for accurate cancer cell recognition and gene silencing

Author:
Wang, Xiangnan; Liu, Lan; Wu, Han; Wu, Zhenkun; Tang, Li-Juan; Jiang, Jian-Hui
Source:
Chemical communications 2021 v.57 no.31 pp. 3816-3819
ISSN:
1364-548X
Subject:
genes,   etc   ; DNA; neoplasm cells;     Show all 3 Subjects
Abstract:
... A dual-aptamer based AND logic cascade circuit is activated on cell membranes in response to the receptor–aptamer binding, affording enhanced specificity for cell subtype recognition and gene silencing. ...
DOI:
10.1039/d1cc00481f

15. Approach for in vivo delivery of CRISPR/Cas system: a recent update and future prospect

Author:
Chuang, Yu-Fan; Phipps, Andrew J.; Lin, Fan-Li; Hecht, Valerie; Hewitt, Alex W.; Wang, Peng-Yuan; Liu, Guei-Sheung
Source:
Cellular and molecular life sciences 2021 v.78 no.6 pp. 2683-2708
ISSN:
1420-682X
Subject:
genes,   etc   ; genomics; humans;     Show all 3 Subjects
Abstract:
... The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) system provides a groundbreaking genetic technology that allows scientists to modify genes by targeting specific genomic sites. Due to the relative simplicity and versatility of the CRISPR/Cas system, it has been extensively applied in human genetic research as well as in agricultural applications, such ...
DOI:
10.1007/s00018-020-03725-2

16. AUF1, an mRNA decay factor, has a discordant role in Cpeb1 expression

Author:
Oe, Souichi; Koike, Taro; Hirahara, Yukie; Tanaka, Susumu; Hayashi, Shinichi; Nakano, Yosuke; Kase, Masahiko; Noda, Yasuko; Yamada, Hisao; Kitada, Masaaki
Source:
Biochemical and biophysical research communications 2021 v.534 pp. 491-497
ISSN:
0006-291X
Subject:
gene expression,   etc   ; plasmids; research;     Show all 3 Subjects
Abstract:
... Cytoplasmic polyadenylation element binding protein 1 (CPEB1) regulates polyadenylation and subsequent translation of CPE-containing mRNAs involved in various physiological and pathological phenomena. Although the significance of CPEB1-mediated translational regulation has recently been reported, the detailed regulatory mechanism of Cpeb1 expression remains unclear. To elucidate the post-transcrip ...
DOI:
10.1016/j.bbrc.2020.11.054

17. Speculating on the Roles of Nuclear Speckles: How RNA‐Protein Nuclear Assemblies Affect Gene Expression

Author:
Hasenson, Sarah E.; Shav‐Tal, Yaron
Source:
BioEssays 2020 v.42 no.10 pp. e2000104
ISSN:
0265-9247
Subject:
gene expression; genes,   etc   ; genomics;     Show all 3 Subject
Abstract:
... Nuclear speckles are eukaryotic nuclear bodies enriched in splicing factors. Their exact purpose has been a matter of debate. The different proposed roles of nuclear speckles are reviewed and an additional layer of function is put forward, suggesting that by accumulating splicing factors within them, nuclear speckles can buffer the nucleoplasmic levels of splicing factors available for splicing an ...
DOI:
10.1002/bies.202000104

18. A Novel Eukaryote‐Like CRISPR Activation Tool in Bacteria: Features and Capabilities

Author:
Liu, Yang; Wang, Baojun
Source:
BioEssays 2020 v.42 no.6 pp. e1900252
ISSN:
0265-9247
Subject:
gene activation; genes,   etc   ; biotechnology;     Show all 3 Subject
Abstract:
... CRISPR (clustered regularly interspaced short palindromic repeats) activation (CRISPRa) in bacteria is an attractive method for programmable gene activation. Recently, a eukaryote‐like, σ⁵⁴‐dependent CRISPRa system has been reported. It exhibits high dynamic ranges and permits flexible target site selection. Here, an overview of the existing strategies of CRISPRa in bacteria is presented, and the ...
DOI:
10.1002/bies.201900252

19. Analysis of the proteolytic system of Streptococcus thermophilus strains CS5, CS9, CS18 and CS20

Author:
Hu, Tong; Cui, Yanhua; Qu, Xiaojun
Source:
International dairy journal 2021 v.118 pp. 105025
ISSN:
0958-6946
Subject:
gene expression; genes,   etc   ; Streptococcus thermophilus; fermentation; milk; proteolysis; transcription factors;     Show all 7 Subjects
Abstract:
... Streptococcus thermophilus is a common milk starter, and the ability to hydrolyse proteins is an important property. The proteolytic systems of S. thermophilus strains CS5, CS9, CS18 and CS20 have been investigated according to their genomes. The growth and proteolytic abilities of these strains have been analysed in combination with gene expressions of both the proteolytic system and the two-comp ...
DOI:
10.1016/j.idairyj.2021.105025

20. Conditional gene knockdowns in sea urchins using caged morpholinos

Author:
Bardhan, Anirban; Deiters, Alexander; Ettensohn, Charles A.
Source:
Developmental biology 2021 v.475 pp. 21-29
ISSN:
0012-1606
Subject:
gene expression; genes,   etc   ; ; Danio rerio; Echinoidea; embryogenesis; oligonucleotides;     Show all 7 Subjects
Abstract:
... Echinoderms are important experimental models for analyzing embryonic development, but a lack of spatial and temporal control over gene perturbations has hindered developmental studies using these animals. Morpholino antisense oligonucleotides (MOs) have been used successfully by the echinoderm research community for almost two decades, and MOs remain the most widely used tool for acute gene knock ...
DOI:
10.1016/j.ydbio.2021.02.014