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genomics, etc ; fumarates; oxidoreductases; phylogeny; succinic acid; Show all 5 Subjects
Abstract:
... Succinate dehydrogenases (SDHs) and fumarate reductases (FRDs) catalyse the interconversion of succinate and fumarate, a reaction highly conserved in all domains of life. The current classification of SDH/FRDs is based on the structure of the membrane anchor subunits and their cofactors. It is, however, unknown whether this classification would hold in the context of evolution. In this work, a lar ...
genomics, etc ; DNA methylation; audiometry; computer software; elderly; genes; models; speech; China; Show all 9 Subjects
Abstract:
... To explore the differences in DNA methylation associated with age-related hearing loss in a study of 57 twin pairs from China. Monozygotic twins were identified through the Qingdao Twin Registration system. The median age of participants was > 50 years. Their hearing thresholds were measured using a multilevel pure-tone audiometry assessment. The pure-tone audiometry was calculated at low frequenc ...
genomics, etc ; DNA; RNA; Vesiculovirus; chickens; cytosol; humans; immunology; nuclear matrix; ribonucleoproteins; Show all 10 Subjects
Abstract:
... In mammals, heterogeneous ribonucleoprotein U (hnRNPU), also named as nuclear matrix protein-nuclear scaffold attachment factor (SAFA), was originally identified as a DNA/RNA interactor protein. It has been reported that human hnRNPU facilitates IFN-β generation after vesicular stomatitis virus (VSV) infection. Nevertheless, the role of chicken hnRNPU (chhnRNPU) in IFN-β regulation as well as in i ...
... A novel strain, Nitratireductor sp. GZWM139 capable of efficient removal of SMX was isolated from mariculture sewage, and Nitratireductor was reported to conduct the removal of antibiotics for the first time. Strain GZWM139 exhibited desirable adaptations to environmental factors with SMX removal efficiencies more than 90 % at temperatures of 28–38 °C, pH values of 4.5–8.5, salinities of 20–30 ‰, ...
... The aerobic, lincomycin-degrading bacterial strain Conexibacter sp. LD01, belonging to the phylum Actinobacteria, was isolated from activated sludge. Both second- and third-generation sequencing technologies were applied to uncover the genomic characterization and high-quality genome with 99.2% completeness and 2.2% contamination was obtained. The biodegradation kinetics of lincomycin fit well wit ...
genomics, etc ; DNA; Holothuria scabra; aquaculture; dimorphism; females; loop-mediated isothermal amplification; males; phenotype; rapid methods; reproduction; South East Asia; Show all 12 Subjects
Abstract:
... As one of the most economically significant sea cucumber species, Holothuria scabra are naturally distributed in the Indo-West Pacific region and are widely cultural in Southeast Asia. The appearances of female and male H. scabra have no obvious phenotypic dimorphism. Thus, identification of sex-specific markers and establishment of sex detection methods are beneficial to artificially induced repr ...
genomics, etc ; CRISPR-Cas systems; Larimichthys crocea; aquaculture; chorion; disease resistance; genes; genetic improvement; green fluorescent protein; meat quality; mutants; plasmids; survival rate; China; Show all 14 Subjects
Abstract:
... The large yellow croaker (Larimichthys crocea) is an economically important marine species with the highest annual production among the farmed marine fishes in China. However, the aquaculture industry of this species is suffering from severe problems that include weakened disease resistance, decreased growth rate, and reduced meat quality due to frequent inbreeding. Genome editing, which has a hug ...
... Vibrio parahaemolyticus is a major seafood-borne zoonotic pathogen causing gastroenteritis in humans. Although antibiotics are the most effective chemical agents for V. parahaemolyticus, their abuse has caused the emergence of multidrug-resistant strains, affecting seafood safety. Here, we have isolated and characterized the V. parahaemolyticus bacteriophage VPG01 as an eco-friendly sustainable al ...
genomics, etc ; Clarias macrocephalus; DNA; aquaculture; body weight; catfish; cost effectiveness; genes; genetic improvement; genetic variance; genome-wide association study; genotyping; heritability; marker-assisted selection; parentage; phenotype; prediction; technology; variance; zinc finger motif; Show all 20 Subjects
Abstract:
... Next-generation sequencing (NGS) enables cost-effective exploration of genome-wide single nucleotide polymorphisms (SNPs). This new technology has made enormous contributions in various fields including genetic improvement. This study was conducted to identify SNPs that associated with growth traits (body weight, standard length, and total length) of bighead catfish (Clarias macrocephalus Günther, ...
... The doubling of the plant genome causes obvious morphological and physiological changes, and DNA 5-methylcytosine (5mCs) modification is a key epigenetic component that helps neopolyploids overcome challenges and acquire advantages. In the study of autotetraploid grape, we found that leaf thickness, photosynthetic and antioxidant capacity increased and anthocyanin coloring decreased in autotetrapl ...
genomics, etc ; Larimichthys crocea; Porcine epidemic diarrhea virus; RNA; Severe acute respiratory syndrome coronavirus 2; Transmissible gastroenteritis virus; cold chain; color; culture media; decontamination; fish; food safety; irradiation; nonthermal processing; pH; quantitative polymerase chain reaction; risk reduction; total volatile basic nitrogen; transmission electron microscopy; viruses; Show all 20 Subjects
Abstract:
... The detection of infectious SARS-CoV-2 in food and food packaging associated with the cold chain has raised concerns about the possible transmission pathway of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in foods transported through cold-chain logistics and the need for novel decontamination strategies. In this study, the effect of electron beam (E-beam) irradiation on the inactiv ...
... Technological advances have enabled the rapid generation of health and genomic data, though rarely do these technologies account for the values and priorities of marginalized communities. In this commentary, we conceptualize a blockchain genomics data framework built out of the concept of Indigenous Data Sovereignty. ...
... Short tandem repeats (STRs) play a crucial role in genetic diseases. However, classic disease models such as inbred mice lack such genome wide data in public domain. The examination of STR alleles present in the protein coding regions (are known as protein tandem repeats or PTR) can provide additional functional layer of phenotype regulars. Motivated with this, we analysed the whole genome sequenc ...
... Anorexia nervosa (AN) is a complex disorder with a strong genetic component. Comorbidities are frequent and there is substantial overlap with other disorders. The lack of understanding of the molecular and neuroanatomical causes has made it difficult to develop effective treatments and it is often difficult to treat in clinical practice. Recent advances in genetics have changed our understanding o ...
... Recent studies suggest that transcript isoforms significantly overlap (approximately 60%) between brain tissue and Epstein–Barr virus-transformed lymphoblastoid cell lines (LCLs). Interestingly, 14 cohesion-related genes with variants that cause Cornelia de Lange Syndrome (CdLS) are highly expressed in the brain and LCLs. In this context, we first performed RNA sequencing of LCLs from 22 solved (w ...
... Plants produce a remarkable diversity of structurally and functionally diverse natural chemicals that serve as adaptive compounds throughout their life cycles. However, unlocking this metabolic diversity is significantly impeded by the size, complexity, and abundant repetitive elements of typical plant genomes. As genome sequencing becomes routine, we anticipate that links between metabolic divers ...
... BACKGROUND: Missing data are a common problem in large-scale datasets and its appropriate handling is crucial for data analyses. Missingness can be categorized as (1) missing completely at random (MCAR), (2) missing at random (MAR), and (3) missing not at random (MNAR). Different missingness mechanisms require different imputation strategies. Multiple imputation, an approach for averaging outcomes ...
... Detecting large genomic inversions has long been challenging. In a new study, Porubsky et al. resolve these complex rearrangements in 41 individuals and discover wide regions that undergo recurrent inversions, some of which even toggle back and forth (Porubsky et al., 2022). Many of these regions are associated with genomic disorders. ...
... Knowledge of the higher-level phylogenetic relationships of birds has grown substantially during the past two decades due to the application of genomic data. However, the nomenclature of higher-level taxa has not become more stable, due to the lack of regulation of taxon names above the level of superfamily by the ICZN, and the usage of rank-based nomenclature, which is not tied to clades in a phy ...