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1. Purification and characterization of hypoglycemic peptides from traditional Chinese soy-fermented douchi

Author:
Songfeng Yu; Ling Liu; Tingting Bu; Jiexia Zheng; Wenjun Wang; Jianping Wu; Donghong Liu
Source:
Food & function 2022 v.13 no.6 pp. 3343-3352
ISSN:
2042-650X
Subject:
glucose; glucose transporters,   etc   ; douchi; gel chromatography; peptides; China;     Show all 6 Subjects
Abstract:
... Douchi is a popular soy-fermented food that originated in China with documented hypoglycemic effects. However, the responsible molecules and the mechanism underlying their beneficial effects remain unclear. Therefore, in this study, we aimed to identify the responsible peptide(s) in douchi. A peptide extract of douchi was isolated step-wise by the C₁₈ Sep-Pak technique, size exclusion chromatograp ...
DOI:
10.1039/d1fo03941e

2. Facile immobilization of glucose oxidase with Cu3(PO4)2·3H2O for glucose biosensing via smartphone

Author:
Yuhang Zhang; Yan Zhang; Chuankai Yang; Chunyun Ma; Miaorong Zhang; Jianguo Tang
Source:
Colloids and surfaces 2022 v.210 pp. 112259
ISSN:
0927-7765
Subject:
glucose; glucose oxidase,   etc   ; biomineralization; color; colorimetry; hybrids; mobile telephones;     Show all 7 Subjects
Abstract:
... A smartphone-based colorimetric platform for facile glucose detection was constructed below. First, glucose oxidase-Cu₃(PO₄)₂·3H₂O hybrid microflowers (GOx-HMFs) were facilely synthesized via biomineralization, which can react with glucose and 3,3′,5,5′-tetramethylbenzidine to generate colored product. Next, the color information of product was real-time collected and processed via smartphone to r ...
DOI:
10.1016/j.colsurfb.2021.112259

3. Glycopolymer Nanoparticles with On-Demand Glucose-Responsive Insulin Delivery and Low-Hypoglycemia Risks for Type 1 Diabetic Treatment

Author:
Yun Fu; Yuxin Sun; Meng Chen; Wenqian Xing; Yufang Xu; Xuhong Qian; Weiping Zhu
Source:
Biomacromolecules 2022 v.23 no.3 pp. 1251-1258
ISSN:
1526-4602
Subject:
blood glucose; glucose,   etc   ; glycemic control; hypoglycemia; insulin; polymers; polyols;     Show all 7 Subjects
Abstract:
... Diabetic patients with type 1 or advanced type 2 stages need timely and precise insulin injection to regulate the daily blood glucose levels (BGLs). Otherwise, risks of serious or even deadly diabetes-associated complications occur. To achieve prolonged glucose regulation and low hypoglycemia risks, a novel on-demand glucose-responsive glycopolymer system was constructed for insulin delivery, whic ...
DOI:
10.1021/acs.biomac.1c01496

4. Smart erythrocyte-hitchhiking insulin delivery system for prolonged automatic blood glucose control

Author:
Min Li; Xiaomin Xu; Rongying Shi; Yuai Li; Qing Lin; Tao Gong; Xun Sun; Zhirong Zhang; Ling Zhang
Source:
Biomaterials science 2022 v.10 no.10 pp. 2638-2649
ISSN:
2047-4849
Subject:
blood glucose; glucose; glucose oxidase,   etc   ; automation; biocompatible materials; blood flow; catalase; chitosan; erythrocytes; glucosamine; glycemic control; insulin;     Show all 12 Subjects
Abstract:
... Long and automatic control of blood glucose levels in diabetic patients could solve the problems caused by frequent insulin injections. Herein, we exploited the protection potential of erythrocytes by a “hitchhiking” strategy to significantly prolong the blood circulation time of a specifically-designed smart hitchhiking insulin delivery system (SHIDS). In the SHIDS, insulin, glucose oxidase, and ...
DOI:
10.1039/d2bm00280a

5. Comparison of preoperative to postoperative blood glucose in puppies undergoing elective surgical neutering

Author:
J.M. Fudge; I. Lee; B. Page; U. Jeffery
Source:
veterinary journal 2022 v.281 pp. 105811
ISSN:
1090-0233
Subject:
blood glucose; glucose,   etc   ; blood; blood proteins; fasting; hypoglycemia; juveniles; puppies;     Show all 8 Subjects
Abstract:
... The objective of this study was to determine if overnight fasting is associated with hypoglycemia in puppies undergoing elective surgical neutering. One hundred seventy-one apparently healthy puppies between the age of 2 and 6 months presented for elective surgical neutering. Owners were instructed to withhold food from puppies after midnight the night before surgery; water was to be freely availa ...
DOI:
10.1016/j.tvjl.2022.105811

6. Neuronatin gene expression levels affect foetal growth and development by regulating glucose transport in porcine placenta

Author:
Pingping Xing; Linjun Hong; Guanhao Yan; Baohua Tan; Jiaxin Qiao; Shanshan Wang; Zicong Li; Jie Yang; Enqin Zheng; Gengyuan Cai; Zhenfang Wu; Ting Gu
Source:
Gene 2022 v.809 pp. 146051
ISSN:
0378-1119
Subject:
glucose; glucose transporters,   etc   ; calcium; fetus; genes; growth and development; pregnancy; trophoblast;     Show all 8 Subjects
Abstract:
... Imprinted genes play important regulatory roles in the growth and development of placentas and foetuses during pregnancy. In a previous study, we found that the imprinted gene Neuronatin (NNAT) is involved in foetal development; NNAT expression was significantly lower in the placentas of piglets that died neonatally compared to the placentas of surviving piglets. However, the function and mechanis ...
DOI:
10.1016/j.gene.2021.146051

7. Review of present method of glucose from human blood and body fluids assessment

Author:
Klara Fiedorova; Martin Augustynek; Jan Kubicek; Petr Kudrna; Daniele Bibbo
Source:
Biosensors & bioelectronics 2022 v.211 pp. 114348
ISSN:
0956-5663
Subject:
blood glucose; glucose,   etc   ; biosensors; blood; diabetes mellitus; humans; insulin; markets; surveys;     Show all 9 Subjects
Abstract:
... the work has been aimed to create an overview of available and used methods and ways to determine the concentration of glucose in body fluids, especially from a technical point of view. It also provides an overview of the clinical features of these methods. The survey found that today's market offers a large number of options and approaches to the issue. There are accurate reference laboratory met ...
DOI:
10.1016/j.bios.2022.114348

8. The impact of weight cycling on health outcomes in animal models: A systematic review and meta‐analysis

Author:
Senthil Thillainadesan; Søren Madsen; David E. James; Samantha L. Hocking
Source:
Obesity reviews 2022 v.23 no.5 pp. e13416
ISSN:
1467-7881
Subject:
glucose; glucose tolerance,   etc   ; humans; meta-analysis; obesity; systematic review; weight loss;     Show all 7 Subjects
Abstract:
... The pattern of weight loss and regain, termed “weight cycling,” is common in overweight individuals. It is unclear whether the well‐established benefits of weight loss persist following weight regain or whether weight cycling is harmful. Human studies of weight cycling have conflicting results reflecting limitations of the observational designs of these studies. By controlling the macronutrient co ...
DOI:
10.1111/obr.13416

9. Association between hepatic iron overload assessed by magnetic resonance imaging and glucose intolerance states in the general population

Author:
Muhammad Naeem; Sabine Schipf; Robin Bülow; Nicole Werner; Marcus Dörr; Markus M. Lerch; Jens-Peter Kühn; Wolfgang Rathmann; Matthias Nauck; Marcello Ricardo Paulista Markus; Giovanni Targher; Till Ittermann; Henry Völzke
Source:
Nutrition, metabolism, and cardiovascular diseases 2022 pp. -
ISSN:
0939-4753
Subject:
blood glucose; glucose; glucose tolerance,   etc   ; biomarkers; iron; iron overload; lipid content; magnetism; noninsulin-dependent diabetes mellitus; nutrition; regression analysis; relative risk;     Show all 12 Subjects
Abstract:
... While there is evidence that iron overload disorders are associated with type 2 diabetes, the relationship between hepatic iron overload and prediabetes remains unclear. We aimed to investigate the association between hepatic iron overload, as assessed by magnetic resonance imaging (MRI), and different glucose intolerance states in the population-based Study. We included data from 1622 individuals ...
DOI:
10.1016/j.numecd.2022.02.013

10. Performance enhancement strategies for surface plasmon resonance sensors in direct glucose detection using pristine and modified UiO-66: effects of morphology, immobilization technique, and signal amplification

Author:
Gilang Gumilar; Joel Henzie; Brian Yuliarto; Aep Patah; Nugraha Nugraha; Muhammad Iqbal; Mohammed A. Amin; Md. Shariar A. Hossain; Yusuke Yamauchi; Yusuf Valentino Kaneti
Source:
Journal of materials chemistry A 2022 v.10 no.12 pp. 6662-6678
ISSN:
2050-7496
Subject:
blood glucose; glucose; glucose oxidase,   etc   ; adsorption; blood serum; concanavalin A; detection limit; diabetes; humans; hydrogen; insulin; porous media; surface plasmon resonance;     Show all 13 Subjects
Abstract:
... Diabetes is a dangerous disease caused by the inability of the body to produce and use insulin properly, resulting in an increase in the blood glucose level. The most advanced technology for glucose detection is the surface plasmon resonance (SPR)-based sensor. However, this technology has a slight drawback due to the small size of glucose. As a porous material, Zr-based UiO-66 MOF has good adsorp ...
DOI:
10.1039/d1ta08741j

11. Influence of enzyme immobilization and skin-sensor interface on non-invasive glucose determination from interstitial fluid obtained by magnetohydrodynamic extraction

Author:
Emily Kemp; Tommi Palomäki; Ida A. Ruuth; Zhanna A. Boeva; Teemu A. Nurminen; Risto T. Vänskä; Laura K. Zschaechner; Alejandro García Pérez; Tuuli A. Hakala; Melissa Wardale; Edward Haeggström; Johan Bobacka
Source:
Biosensors & bioelectronics 2022 v.206 pp. 114123
ISSN:
0956-5663
Subject:
glucose; glucose oxidase,   etc   ; biosensors; chitosan; hydrogels; immobilized enzymes; mass transfer; nanofibers; swine;     Show all 9 Subjects
Abstract:
... We integrated a magnetohydrodynamic fluid extractor with an amperometric glucose biosensor to develop a wearable device for non-invasive glucose monitoring. Reproducible fluid extraction through the skin and efficient transport of the extracted fluid to the biosensor surface are prerequisites for non-invasive glucose monitoring. We optimized the enzyme immobilization and the interface layer betwee ...
DOI:
10.1016/j.bios.2022.114123

12. A detailed review on the phytochemical profiles and anti-diabetic mechanisms of Momordicacharantia

Author:
Sunday Faith Oyelere; Oluwatobi Hezekiah Ajayi; Titilayo Eunice Ayoade; George Bueno Santana Pereira; Bolaji Charles Dayo Owoyemi; Ajibola Olaoluwa Ilesanmi; Olalekan Amos Akinyemi
Source:
Heliyon 2022 v.8 no.4 pp. e09253
ISSN:
2405-8440
Subject:
glucose; glucose-6-phosphatase,   etc   ; absorption; catabolism; diabetes mellitus; insulin; insulin resistance; mortality; phytochemicals;     Show all 9 Subjects
Abstract:
... Diabetes mellitus is the most well-known endocrine dilemma suffered by hundreds of million people globally, with an annual mortality of more than one million people. This high mortality rate highlights the need for in-depth study of anti-diabetic agents. This review explores the phytochemical contents and anti-diabetic mechanisms of M. charantia (cucurbitaceae). Studies show that M. charantia cont ...
DOI:
10.1016/j.heliyon.2022.e09253

13. A platinum nanourchin-based multi-enzymatic platform to disrupt mitochondrial function assisted by modulating the intracellular H2O2 homeostasis

Author:
Jiansen Huang; Yongcan Li; Lei Zhang; Jie Wang; Zhigang Xu; Yuejun Kang; Peng Xue
Source:
Biomaterials 2022 v.286 pp. 121572
ISSN:
0142-9612
Subject:
glucose; glucose oxidase,   etc   ; biocompatible materials; catalase; homeostasis; manganese; mitochondria; neoplasms; platinum; starvation; therapeutics;     Show all 11 Subjects
Abstract:
... Endogenous H₂O₂ sacrifices for diversified therapeutic reactions against tumor. However, the treatment outcome is not always satisfactory owing to the unsustainable H₂O₂ supply from tumor microenvironment (TME). Herein, a platinum (Pt) nanourchin-based multi-enzymatic platform (referred to PGMA) is established by surface conjugation of glucose oxidase (GOx) capped with manganese carbonyl (MnCO) an ...
DOI:
10.1016/j.biomaterials.2022.121572

14. Glycolysis and gluconeogenesis are involved of glucose metabolism adaptation during fasting and re-feeding in black carp (Mylopharyngodon piceus)

Author:
Yafan Dai; Yubang Shen; Jiamin Guo; Hao Yang; Feng Chen; Wei Zhang; Wenhui Wu; Xiaoyan Xu; Jiale Li
Source:
Aquaculture and fisheries 2022 pp. -
ISSN:
2468-550X
Subject:
blood glucose; glucose; glucose transporters,   etc   ; Mylopharyngodon piceus; aquaculture; carboxy-lyases; fish; gene expression; glucagon; glucocorticoids; glucokinase; gluconeogenesis; glucose-6-phosphatase; glycogen; glycolysis; hexokinase; homeostasis; hunger; insulin; liver; muscles; nutritional status; pyruvate kinase; refeeding;     Show all 24 Subjects
Abstract:
... Both in nature and in aquaculture, fish may experience periods of food scarcity or hunger. The metabolic regulation of fish when nutritional state changes is a complex process that involves many factors. To study glucose metabolism adaptability during fasting and re-feeding in the black carp (Mylopharyngodon piceus), we measured changes in some biochemical indicators related to glucose metabolism. ...
DOI:
10.1016/j.aaf.2022.04.003

15. Milled flaxseed-added diets ameliorated hepatic inflammation by reducing gene expression of TLR4/NF-κB pathway and altered gut microbiota in STZ-induced type 1 diabetic mice

Author:
Hui Xia; Xiangling Shi; Beijia Zhou; Jing Sui; Chao Yang; Hechun Liu; Ligang Yang; Shaokang Wang; Guiju Sun
Source:
Food science and human wellness 2022 v.11 no.1 pp. 32-40
ISSN:
2213-4530
Subject:
blood glucose; glucose tolerance; glucose tolerance tests,   etc   ; diabetes; diet; food science; gene expression; glycogen; humans; inflammation; intestinal microorganisms; linseed; liver; liver neoplasms; necrosis; streptozotocin;     Show all 16 Subjects
Abstract:
... Flaxseed has displayed the potential beneficial as functional foods. However, most studies focused on effects of flaxseed extracts or ingredients in flaxseed. Besides, few studies showed that flaxseed extracts contributed to anti-type 1 diabetes (T1D), yet the underlying mechanism is still unknown. In the present study, 16.7% of milled flaxseed (MF)-added diet was given to diabetic mice induced by ...
DOI:
10.1016/j.fshw.2021.07.004

16. Enzyme-Based Mesoporous Nanomotors with Near-Infrared Optical Brakes

Author:
Mengli Liu; Liang Chen; Zaiwang Zhao; Minchao Liu; Tiancong Zhao; Yuzhu Ma; Qiaoyu Zhou; Yasseen S. Ibrahim; Ahmed A. Elzatahry; Xiaomin Li; Dongyuan Zhao
Source:
Journal of the American Chemical Society 2022 v.144 no.9 pp. 3892-3901
ISSN:
1520-5126
Subject:
glucose; glucose oxidase,   etc   ; biofuels; catalase; catalytic activity; drugs; irradiation; nanospheres; organosilicon compounds; porous media;     Show all 10 Subjects
Abstract:
... As one of the most important parameters of the nanomotors’ motion, precise speed control of enzyme-based nanomotors is highly desirable in many bioapplications. However, owing to the stable physiological environment, it is still very difficult to in situ manipulate the motion of the enzyme-based nanomotors. Herein, inspired by the brakes on vehicles, the near-infrared (NIR) “optical brakes” are in ...
DOI:
10.1021/jacs.1c11749

17. Glycaemia dynamics in gestational diabetes mellitus

Author:
Paola Valero; Rodrigo Salas; Fabián Pardo; Marcelo Cornejo; Gonzalo Fuentes; Sofía Vega; Adriana Grismaldo; Jan-Luuk Hillebrands; Eline M. van der Beek; Harry van Goor; Luis Sobrevia
Source:
Biochimica et biophysica acta 2022 v.1866 no.7 pp. 130134
ISSN:
0304-4165
Subject:
blood glucose; glucose,   etc   ; fetus; gestational diabetes; hyperglycemia; hypoglycemia; neonates; pregnancy outcome; time series analysis;     Show all 9 Subjects
Abstract:
... Pregnant women may develop gestational diabetes mellitus (GDM), a disease of pregnancy characterised by maternal and fetal hyperglycaemia with hazardous consequences to the mother, the fetus, and the newborn. Maternal hyperglycaemia in GDM results in fetoplacental endothelial dysfunction. GDM-harmful effects result from chronic and short periods of hyperglycaemia. Thus, it is determinant to keep g ...
DOI:
10.1016/j.bbagen.2022.130134

18. H₂O₂ Self-Supplementing and GSH-Depleting Nanoreactors Based on MoO₃–ₓ@Fe₃O₄-GOD-PVP for Photothermally Reinforced Nanocatalytic Cancer Therapy at the Second Near-Infrared Biowindow

Author:
Fan Wu; Changgao Huang; Baohong Sun; Zhihui Zhu; Wenquan Cheng; Yanjun Chen; Chenhao Liao; Ruping Xu; Mihai’ernisaguli Maimaititu’ersun; Ninglin Zhou; Feng Han; Zheng Cai; Huijun Jiang
Source:
ACS sustainable chemistry & engineering 2022 v.10 no.19 pp. 6346-6357
ISSN:
2168-0485
Subject:
glucose; glucose oxidase,   etc   ; absorption; cancer therapy; catalytic activity; fever; glutathione; green chemistry; neoplasms; polyvinylpyrrolidone;     Show all 10 Subjects
Abstract:
... Nanocatalytic therapy is an emerging strategy for combating various malignant tumors, which is limited by acid/H₂O₂ deficiency and overexpressed glutathione (GSH). Herein, the versatile MoO₃–ₓ@Fe₃O₄-GOD-PVP (MFGP) nanoreactors were developed to overcome the limitations of nanocatalytic therapy. First, MoO₃–ₓ nanoflakes were loaded with Fe₃O₄ nanozymes via electrostatic self-assembly and then decor ...
DOI:
10.1021/acssuschemeng.2c00964

19. Lactate dehydrogenase regulates basal glucose uptake in adipocytes

Author:
Tomomi Minemura; Atsunori Fukuhara; Michio Otsuki; Iichiro Shimomura
Source:
Biochemical and biophysical research communications 2022 v.607 pp. 20-27
ISSN:
0006-291X
Subject:
blood glucose; glucose,   etc   ; adipocytes; adipose tissue; glycolysis; lactate dehydrogenase; protein degradation; research; tissue weight;     Show all 9 Subjects
Abstract:
... Plasma glucose levels are homeostatically regulated within strict boundaries and are maintained through a balance between peripheral glucose uptake and hepatic glucose production. However, little is known about the regulatory mechanism of glucose uptake in adipocytes during fasting. Under fasting conditions, the expression levels of 8 glycolytic enzymes were significantly reduced in adipose tissue ...
DOI:
10.1016/j.bbrc.2022.03.113

20. MXene nanoflakes decorating ZnO tetrapods for enhanced performance of skin-attachable stretchable enzymatic electrochemical glucose sensor

Author:
Valerii Myndrul; Emerson Coy; Nataliya Babayevska; Veronika Zahorodna; Vitalii Balitskyi; Ivan Baginskiy; Oleksiy Gogotsi; Mikhael Bechelany; Maria Teresa Giardi; Igor Iatsunskyi
Source:
Biosensors & bioelectronics 2022 v.207 pp. 114141
ISSN:
0956-5663
Subject:
blood glucose; glucose,   etc   ; biosensors; blood; detection limit; electrical conductivity; electrochemistry; humans; physical activity; sweat;     Show all 10 Subjects
Abstract:
... Continuous painless glucose monitoring is the greatest desire of more than 422 million diabetics worldwide. Therefore, new non-invasive and convenient approaches to glucose monitoring are more in demand than other tests for microanalytical diagnostic tools. Besides, blood glucose detection can be replaced by continuous glucose monitoring of other human biological fluids (e.g. sweat) collected non- ...
DOI:
10.1016/j.bios.2022.114141