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1. Effects of Desiccation on Metamorphic Climax in Bombina variegata: Changes in Levels and Patterns of Oxidative Stress Parameters

Author:
Petrović, Tamara G.; Kijanović, Ana; Kolarov Tomašević, Nataša; Gavrić, Jelena P.; Despotović, Svetlana G.; Gavrilović, Branka R.; Radovanović, Tijana B.; Vukov, Tanja; Faggio, Caterina; Prokić, Marko D.
Source:
Animals 2021 v.11 no.4
ISSN:
2076-2615
Subject:
glutathione; glutathione peroxidase; glutathione transferase,   etc   ; antioxidants; catalase; lipids; oxidative stress;     Show all 7 Subjects
Abstract:
... In this paper, we examined how the oxidative status (antioxidant system and oxidative damage) of Bombina variegata larvae changed during the metamorphic climax (Gosner stages: 42—beginning, 44—middle and 46—end) and compared the patterns and levels of oxidative stress parameters between individuals developing under constant water availability (control) and those developing under decreasing water a ...
DOI:
10.3390/ani11040953

2. A tris(benzyltriazolemethyl)amine-based cage as a CuAAC ligand tolerant to exogeneous bulky nucleophiles

Author:
Qiu, Gege; Nava, Paola; Martinez, Alexandre; Colomban, Cédric
Source:
Chemical communications 2021 v.57 no.18 pp. 2281-2284
ISSN:
1364-548X
Subject:
glutathione,   etc   ; Lewis bases; ligands;     Show all 3 Subjects
Abstract:
... The archetypal tris(benzyltriazolemethyl)amine (TBTA) ligand was equipped with a bowl-shaped cap in the cage Hm-TBTA. Hm-TBTA accelerates CuAAC reactions without suffering from product inhibition. Furthermore, this shielded ligand efficiently protects the copper center from deactivation by the Cuᴵ–chelator glutathione, opening the way to novel approaches for efficient CuAAC reactions in complex me ...
DOI:
10.1039/d0cc08005e

3. Synthesis of glutathione as a central aspect of PAH toxicity in liver cells: A comparison between phenanthrene, Benzo[b]Fluoranthene and their mixtures

Author:
Branco, Vasco; Matos, Beatriz; Mourato, Carolina; Diniz, Mário; Carvalho, Cristina; Martins, Marta
Source:
Ecotoxicology and environmental safety 2021 v.208 pp. 111637
ISSN:
0147-6513
Subject:
glutathione; glutathione peroxidase; glutathione synthase,   etc   ; ; cell viability; cysteine; cytotoxicity; ecotoxicology; glutathione transferase; glutathione-disulfide reductase; liver; phenanthrenes; risk assessment;     Show all 13 Subjects
Abstract:
... Polycyclic Aromatic Hydrocarbons (PAH) are a class of organic pollutants normally found as mixtures with effects often hard to predict, which poses a major challenge for risk assessment. In this study, we address the effects of Phenanthrene (Phe), benzo[b]fluoranthene (B[b]F) and their mixtures (2 Phe:1 B[b]F; 1 Phe: 1 B[b]F; 1 Phe: 2 B[b]F) over glutathione (GSH) synthesis and function in HepG2 c ...
DOI:
10.1016/j.ecoenv.2020.111637

4. Rapid ¹⁸F-labeling via Pd-catalyzed S-arylation in aqueous medium

Author:
Humpert, Swen; Omrane, Mohamed A.; Urusova, Elizaveta A.; Gremer, Lothar; Willbold, Dieter; Endepols, Heike; Krasikova, Raisa N.; Neumaier, Bernd; Zlatopolskiy, Boris D.
Source:
Chemical communications 2021 v.57 no.29 pp. 3547-3550
ISSN:
1364-548X
Subject:
glutathione,   etc   ; ; bovine serum albumin; radiolabeling;     Show all 4 Subjects
Abstract:
... We report radiolabeling of thiol-containing substrates via Pd-catalyzed S-arylation with 2-[¹⁸F]fluoro-5-iodopyridine, which is readily accessible using the “minimalist” radiofluorination method. The practicality of the procedure was confirmed by preparation of a novel PSMA-specific PET-tracer as well as labeling of glutathione, Aβ oligomer-binding RD2 peptide, bovine serum albumin and PSMA I&S. ...
DOI:
10.1039/d1cc00745a

5. Antioxidant activity of Far Eastern bivalves in their natural habitat

Author:
Istomina, Aleksandra; Yelovskaya, Olesya; Chelomin, Viktor; Karpenko, Alexander; Zvyagintsev, Aleksandr
Source:
Marine environmental research 2021 v.169 pp. 105383
ISSN:
0141-1136
Subject:
glutathione; glutathione peroxidase; glutathione-disulfide reductase,   etc   ; Bivalvia; antioxidant activity; catalase; habitats; longevity; research; superoxide dismutase;     Show all 10 Subjects
Abstract:
... The activities of the key antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GP) and glutathione reductase (GR) as well as levels of reduced glutathione (GSH) and integral antioxidant activity (IAA), were studied in the digestive glands and gills of 14 bivalve species. Species and tissue differences of the antioxidant (AO) systems of the investigated mollusks w ...
DOI:
10.1016/j.marenvres.2021.105383

6. Adaptive epigenetic response of glutathione (GSH)-related genes against lead (Pb)-induced toxicity, in individuals chronically exposed to the metal

Author:
Devóz, Paula Pícoli; Reis, Mariana Bisarro dos; Gomes, Willian Robert; Maraslis, Flora Troina; Ribeiro, Diego Luis; Antunes, Lusânia Maria Greggi; Batista, Bruno Lemos; Grotto, Denise; Reis, Rui Manuel; Barbosa Jr., Fernando; Barcelos, Gustavo Rafael Mazzaron
Source:
Chemosphere 2021 v.269 pp. 128758
ISSN:
0045-6535
Subject:
glutathione; glutathione peroxidase; glutathione transferase,   etc   ; biomarkers; blood; epigenetics; high-throughput nucleotide sequencing; lead; males; metabolism; methylation; oxidative stress; toxicity;     Show all 13 Subjects
Abstract:
... It is well known that one of the most outstanding adverse effects related to lead (Pb) exposure is oxidative stress; moreover, recent findings suggest that disturbances of the redox status of cells are associated with epigenetic responses, and metabolism of glutathione (GSH) plays an important role in this process. This study aimed to assess Pb exposure on % methylation of GSH-related genes’ promo ...
DOI:
10.1016/j.chemosphere.2020.128758

7. Effect of ozone treatment on glutathione (GSH) status in selected berry fruit

Author:
Piechowiak, Tomasz
Source:
Phytochemistry 2021 v.187 pp. 112767
ISSN:
0031-9422
Subject:
glutathione; glutathione peroxidase; glutathione synthase,   etc   ; Vaccinium corymbosum; biosynthesis; black currants; blackberries; energy; fruits; glutathione-disulfide reductase; hydrogen peroxide; mitochondria; ozonation; ozone; plant biochemistry; raspberries; strawberries;     Show all 17 Subjects
Abstract:
... The major aim of this study was to investigate the effect of one-time ozone elicitation on glutathione metabolism in selected berry fruit. Raspberry, highbush blueberry, strawberry, blackberry and blackcurrant fruit was ozonated with an ozone concentration of 15 ppm for 30 min. Research showed that ozonation process causes clear and positive changes in the metabolism of glutathione in berries. Aft ...
DOI:
10.1016/j.phytochem.2021.112767

8. Simultaneous sensing of cysteine/homocysteine and glutathione with a fluorescent probe based on a single atom replacement strategy

Author:
Yao, Jingfeng; Yin, Guoxing; Yu, Ting; Li, Haitao; Yin, Peng
Source:
Analytical methods 2021 v.13 no.11 pp. 1358-1363
ISSN:
1759-9679
Subject:
glutathione,   etc   ; cysteine; fluorescence; fluorescent dyes; homocysteine;     Show all 5 Subjects
Abstract:
... In recent years, there have been many reports of fluorescent probes for multi-channel detection of Cys, Hcy and GSH. Particularly, reports of fluorescent probes using NBD (7-nitro-1,2,3-benzoxadiazole) or SNBD (7-nitro-1,2,3-benzothiadiazole) moieties as fluorophores are particularly common. Unfortunately, their 4-sulfhydryl derivatives exhibited negligible fluorescence, which makes them incapable ...
DOI:
10.1039/d0ay02206c

9. Light-driven hydrogen production with CdSe quantum dots and a cobalt glutathione catalyst

Author:
Burke, Rebeckah; Chakraborty, Saikat; McClelland, Kevin P.; Jelušić, Jana; Matson, Ellen M.; Bren, Kara L.; Krauss, Todd D.
Source:
Chemical communications 2021 v.57 no.16 pp. 2053-2056
ISSN:
1364-548X
Subject:
glutathione,   etc   ; catalysts; cobalt; hydrogen; hydrogen production; photocatalysis;     Show all 6 Subjects
Abstract:
... A photocatalytic hydrogen (H₂) production system is reported using glutathione (GSH)-capped CdSe QDs with a cobalt precatalyst, yielding 130 000 mol H₂ per mol cobalt over 48 hours. Analysis of the reaction mixtures after catalysis indicates that the active catalyst is a labile complex of cobalt and GSH formed in situ. ...
DOI:
10.1039/d0cc07364d

10. A multiple-strain probiotic product provides a better enzymatic antioxidant response in individuals with constipation in a double-blind randomized controlled trial

Author:
Araújo, Ananda de M.; Botelho, Patrícia B.; Ribeiro, Dalila Juliana S.; Magalhães, Kelly G.; Nakano, Eduardo Y.; Arruda, Sandra F.
Source:
Nutrition 2021 v.89 pp. 111225
ISSN:
0899-9007
Subject:
glutathione peroxidase; glutathione transferase,   etc   ; antioxidant activity; biomarkers; constipation; defecation; dysbiosis; erythrocytes; intestines; malondialdehyde; nutrition; placebos; probiotics;     Show all 13 Subjects
Abstract:
... Probiotics may have beneficial effects on intestinal dysbiosis. However, the effects of probiotics on redox and inflammatory responses in intestinal constipation remain unknown. The aim of this study was to investigate the effect of a multiple-strain probiotic on the redox and inflammatory responses in individuals with intestinal constipation.A randomized, double-blind, placebo controlled clinical ...
DOI:
10.1016/j.nut.2021.111225

11. Pyroxasulfone-Resistant Annual Ryegrass (Lolium rigidum) Has Enhanced Capacity for Glutathione Transferase-Mediated Pyroxasulfone Conjugation

Author:
Goggin, Danica E.; Cawthray, Gregory R.; Flematti, Gavin R.; Bringans, Scott D.; Lim, Hitormi; Beckie, Hugh J.; Busi, Roberto
Source:
Journal of agricultural and food chemistry 2021 v.69 no.23 pp. 6414-6422
ISSN:
1520-5118
Subject:
glutathione; glutathione transferase,   etc   ; ; Amaranthus tuberculatus; Brachypodium distachyon; Lolium rigidum; coleoptiles; crops; food chemistry; pyroxasulfone; wheat;     Show all 11 Subjects
Abstract:
... The herbicide pyroxasulfone was widely introduced in 2012, and cases of evolved resistance in weeds such as annual ryegrass (Lolium rigidum Gaud.) and tall waterhemp [Amaranthus tuberculatus (Moq.) Sauer] have started to emerge. Pyroxasulfone is detoxified by tolerant crops, and by annual ryegrass that has been recurrently selected with pyroxasulfone, in a pathway that is hypothesized to involve g ...
DOI:
10.1021/acs.jafc.0c07458

12. The effects of Nigella sativa seeds and thymoquinone on aflatoxin phase-2 detoxification through glutathione and glutathione-S-transferase alpha-3, and the relationship between aflatoxin B1-DNA adducts in broilers

Author:
Ates, Mehmet Burak; Ortatatli, Mustafa
Source:
Toxicon 2021 v.193 pp. 86-92
ISSN:
0041-0101
Subject:
glutathione; glutathione transferase,   etc   ; Nigella sativa; aflatoxins; antioxidants; biomarkers; biotransformation; hepatocytes; immunohistochemistry; metabolites; thymoquinone;     Show all 11 Subjects
Abstract:
... The primary pathway of the detoxification of aflatoxin (AF) metabolites occurring at the end of phase-1 biotransformation is glutathione (GSH) conjugation via glutathione-S-transferase (GST) enzyme in phase-2. In this study, the activity of Nigella sativa seeds (NS) and thymoquinone (TQ) on phase-2 detoxification pathways of AF was investigated in light of GSH, GST alpha-3 (GSTA3), and AFB₁-DNA ad ...
DOI:
10.1016/j.toxicon.2021.01.020

13. Programming Integrative Multienzyme Systems and Ionic Strength For Recyclable Synthesis of Glutathione

Author:
Cui, Xiangwei; Wang, Zeyuan; Li, Zonglin; Zhang, Xing; Li, Zhimin
Source:
Journal of agricultural and food chemistry 2021 v.69 no.13 pp. 3887-3894
ISSN:
1520-5118
Subject:
glutathione; glutathione synthase,   etc   ; biocatalysis; catalysts; food chemistry; gene duplication; ionic strength; polyphosphate kinase;     Show all 8 Subjects
Abstract:
... In the enzymatic cascade catalysis, it is a big challenge to construct a stable and reusable catalyst with targeted enzymes. The artificial multienzyme reactor has attracted great attention due to its potential for facilitating the performance of enzyme catalysis. In this study, we set up a reliable system that could assemble polyphosphate kinase (PPK) with bifunctional glutathione synthetase (Gsh ...
DOI:
10.1021/acs.jafc.1c00158

14. Role of ferritinophagy in cystine deprivation-induced cell death in glioblastoma cells

Author:
Hayashima, Kazuki; Kimura, Ikuo; Katoh, Hironori
Source:
Biochemical and biophysical research communications 2021 v.539 pp. 56-63
ISSN:
0006-291X
Subject:
glutathione; phospholipid-hydroperoxide glutathione peroxidase,   etc   ; ammonium sulfate; cystine; ferritin; ferroptosis; glioblastoma; glutamine; lipid peroxidation; lysosomes; research;     Show all 11 Subjects
Abstract:
... Ferroptosis is a form of cell death caused by iron-dependent lipid peroxidation. Cancer cells increase cystine uptake for the synthesis of glutathione (GSH), which is used by glutathione peroxidase 4 to reduce lipid peroxides. Here, we report that cystine deprivation in glioblastoma cells, but not inhibition of GSH synthesis by l-buthionine sulfoximine (BSO), induces ferroptosis. We found that cys ...
DOI:
10.1016/j.bbrc.2020.12.075

15. Non-enzymatic antioxidant responses of Mytilus galloprovincialis: Insights into the physiological role against metal-induced oxidative stress

Author:
Santovito, Gianfranco; Trentin, Erika; Gobbi, Ilaria; Bisaccia, Paola; Tallandini, Laura; Irato, Paola
Source:
Comparative biochemistry and physiology 2021 v.240 pp. 108909
ISSN:
1532-0456
Subject:
glutathione; glutathione-disulfide reductase,   etc   ; Mytilus galloprovincialis; antioxidants; cadmium; malondialdehyde; metallothionein; oxidative stress;     Show all 8 Subjects
Abstract:
... The exposure to metals is known to generate oxidative stress in living organisms, which can result in the induction of protective antioxidant defences, both enzymatic and non-enzymatic. This work aims to obtain new data on the existing links among several non-enzymatic components of the antioxidant system, that are physiologically related to both metal sequestration and defense against metal-induc ...
DOI:
10.1016/j.cbpc.2020.108909

16. Protective efficacy of phenoxyacetyl oxazolidine derivatives as safeners against nicosulfuron toxicity in maize

Author:
Zhang, Yuan‐Yuan; Gao, Shuang; Hoang, Minh‐Tu; Wang, Zi‐Wei; Ma, Xin; Zhai, Yue; Li, Na; Zhao, Li‐Xia; Fu, Ying; Ye, Fei
Source:
Pest management science 2021 v.77 no.1 pp. 177-183
ISSN:
1526-498X
Subject:
glutathione; glutathione transferase,   etc   ; ; acetolactate synthase; corn; crop damage; herbicide safeners; nicosulfuron; toxicity;     Show all 9 Subjects
Abstract:
... BACKGROUND: Herbicide safeners mitigate crop damage without reducing herbicide efficacy. Here, the protective effects of phenoxyacetyl oxazolidine derivatives as potential safeners were evaluated with a view toward reducing injury caused by sulfonylurea herbicide nicosulfuron to sensitive maize varieties. RESULTS: Growth indices demonstrated that the bioactivity of compound 9 (N‐phenoxyacety‐2‐met ...
DOI:
10.1002/ps.6005

17. Ecotoxicological evaluation of water from the Sorocaba River using an integrated analysis of biochemical and morphological biomarkers in bullfrog tadpoles, Lithobates catesbeianus ()

Author:
Fernandes, Isabela Ferreira; Utsunomiya, Heidi Samantha Moraes; de Lacerda Valverde, Bruno Serra; Ferraz, João Victor Cassiel; Fujiwara, Gabriel Hiroshi; Gutierres, Davi Marques; de Oliveira, Classius; Belussi, Lilian Franco; Fernandes, Marisa Narciso; Carvalho, Cleoni dos Santos
Source:
Chemosphere 2021 v.275 pp. 130000
ISSN:
0045-6535
Subject:
glutathione; glutathione peroxidase; glutathione transferase,   etc   ; Lithobates catesbeianus; biomarkers; bullfrogs; catalase; ecotoxicology; kidneys; liver; melanin; muscles; river water; rivers; summer; superoxide dismutase; winter;     Show all 17 Subjects
Abstract:
... Lithobates catesbeianus tadpoles were exposed for 96 h to water from two sites of the Sorocaba River (summer and winter), Ibiúna (PI) and Itupararanga reservoir (PIR) that contained metals. In the liver, in PI, the glutathione peroxidase (GPx) decreased, and the glutathione S-transferase (GST) and carbonyl proteins (PCO) increased. In PIR, the glutathione reduced (GSH) increased, while there was a ...
DOI:
10.1016/j.chemosphere.2021.130000

18. Histological and chemical damage induced by microcystin-LR and microcystin-RR on land snail Helix aspersa tissues after acute exposure

Author:
Zaidi, H.; Amrani, A.; Sedrati, F.; Maaref, H.; Leghrib, F.; Benamara, M.; Amara, H.; Wang, Zhi; Nasri, H.
Source:
Comparative biochemistry and physiology 2021 v.245 pp. 109031
ISSN:
1532-0456
Subject:
glutathione; glutathione peroxidase; glutathione transferase,   etc   ; ; Helix aspersa; acute exposure; antioxidants; biomarkers; catalase; hepatopancreas; histology; intestines; kidneys; microcystin-LR; oxidative stress; physiology; snails; superoxide dismutase; toxicity;     Show all 19 Subjects
Abstract:
... Microcystins (MCs) are the most common cyanotoxins with more than 200 variants. Among these cyanotoxins, microcystin-LR (MC-LR) and microcystin-RR (MC-RR) are the most studied congeners due to their high toxicity and frequent occurrence in surface waters. MC-LR has been detected in more than 75% of natural cyanobacteria bloom, along with other toxic and less toxic congeners. Accumulation of severa ...
DOI:
10.1016/j.cbpc.2021.109031

19. Manilkara hexandra (Roxb.) Dubard Ameliorates Acetic Acid-induced Rat Gastric Ulcer

Author:
Garabadu, Debapriya; Singh, Sonia; Gautam, Tancha
Source:
Journal of dietary supplements 2021 v.18 no.3 pp. 278-292
ISSN:
1939-022X
Subject:
glutathione; glutathione peroxidase; glutathione-disulfide reductase,   etc   ; ; Manilkara; acetic acid; antagonists; bark extracts; catalase; lipid peroxidation; males; mechanism of action; quercetin; rats; stomach; stomach ulcers; superoxide dismutase; therapeutics; trigonelline;     Show all 19 Subjects
Abstract:
... Manilkara hexandra (Roxb; Family:sapotaceae) is reported to exert preventive effect in several experimental ulcer models. However, there is no report of M. hexandra on gastric ulcer healing property. Thus, the present study was designed to evaluate the gastric ulcer healing activity of methanolic stem bark extract of M. hexandra (MH) and to derive a plausible molecular level of mechanism of action ...
DOI:
10.1080/19390211.2020.1770393

20. Acute toxicity and sublethal effects of sodium laureth sulfate on oxidative stress enzymes in benthic oligochaete worm, Tubifex tubifex

Author:
Bhattacharya, Ritwick; Chatterjee, Arnab; Chatterjee, Soumendranath; Saha, Nimai Chandra
Source:
Comparative biochemistry and physiology 2021 v.243 pp. 108998
ISSN:
1532-0456
Subject:
glutathione; glutathione peroxidase; glutathione transferase,   etc   ; ; Tubifex tubifex; acute toxicity; anionic surfactants; autotomy; biomarkers; catalase; lethal concentration 50; malondialdehyde; mucus; oxidative stress; secretion; sodium; sulfates; superoxide dismutase;     Show all 18 Subjects
Abstract:
... The present study was performed to determine the acute toxicity of sodium laureth sulfate (SLES) and its sublethal effects on oxidative stress enzymes in benthic oligochaete worm Tubifex tubifex. The results showed that 96 h median lethal concentration (LC₅₀) value of SLES for Tubifex tubifex is 21.68 mg/l. Moreover exposed worms showed abnormal behaviours including incremented erratic movement, m ...
DOI:
10.1016/j.cbpc.2021.108998