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1. Imbalance in the glutathione system in Opisthorchis felineus infected liver promotes hepatic fibrosis

Author:
Perina, Ekaterina A.; Ivanov, Vladimir V.; Pershina, Alexandra G.; Perekucha, Natalya A.; Dzyuman, Anna N.; Kaminskii, Ilya P.; Saltykova, Irina V.; Sazonov, Alexey E.; Ogorodova, Ludmila M.
Source:
Acta tropica 2019 v.192 pp. 41-48
ISSN:
0001-706X
Subject:
glutathione; glutathione peroxidase; glutathione transferase,   etc   ; Opisthorchis; acetylcysteine; animal models; collagen; liver; liver cirrhosis; liver flukes; opisthorchiasis; oxidation; oxidative stress;     Show all 13 Subjects
Abstract:
... Although data on oxidative stress during liver fluke infection have been previously presented, a comprehensive study of the glutathione system that plays a crucial role in scavenging of reactive oxygen species (ROS) and detoxification of primary and secondary oxidation products has not been addressed yet. In the present study, the hepatic glutathione system was investigated in a hamster model of e ...
DOI:
10.1016/j.actatropica.2019.01.017

2. Potential of Ablation Therapy during Hepatocellular Carcinoma

Author:
Li, Jia Rui; Malhotra, Anshoo; Bi, Jiangang
Source:
Nutrition and cancer 2019 v.71 no.5 pp. 881-885
ISSN:
1532-7914
Subject:
glutathione; glutathione peroxidase; glutathione transferase,   etc   ; catalase; diethylnitrosamine; fluorescent dyes; glutathione-disulfide reductase; hepatoma; laboratory animals; lipid peroxidation; liver; males; membrane fluidity; microvilli; rats; superoxide dismutase; therapeutics; viscosity;     Show all 18 Subjects
Abstract:
... Background: This study explored the potential of ablation therapy on membrane fluidity changes in diethylnitrosamine (DEN) induced hepatic cancer. Methods: Male Wistar rats were segregated into four groups viz., normal control, DEN treated, ablation therapy treated, and DEN ablation therapy treated. We assessed the viscosities as well as fluidity parameters in isolated brush border membranes using ...
DOI:
10.1080/01635581.2018.1531137

3. Ultrafine and monodispersed iridium nanoparticles supported on nitrogen-functionalized carbon: an efficient oxidase mimic for glutathione colorimetric detection

Author:
Huang, Mujia; Wang, Hua; He, Daiping; Jiang, Ping; Zhang, Yun
Source:
Chemical communications 2019 v.55 no.25 pp. 3634-3637
ISSN:
1364-548X
Subject:
glutathione,   etc   ; carbon; colorimetry; enzymes; iridium; nanoparticles; oxidation;     Show all 7 Subjects
Abstract:
... Ultrafine and monodispersed iridium nanoparticles supported on nitrogen-functionalized carbon materials (Ir/NC) were prepared and served as an efficient oxidase mimic for 3′,5,5′-tetramethylbenzidine (TMB) oxidation. Due to the inhibition effect of glutathione (GSH) on TMB oxidation, a sensitive colorimetric GSH detection approach was proposed. ...
DOI:
10.1039/c9cc00279k

4. Gold core-satellite nanostructure linked by oligonucleotides for detection of glutathione with LSPR scattering spectrum

Author:
Liu, Ying-Bo; Zhai, Ting-Ting; Liang, Yan-Yan; Wang, Yue-Bo; Xia, Xing-Hua
Source:
Talanta 2019 v.193 pp. 123-127
ISSN:
0039-9140
Subject:
glutathione,   etc   ; gold; mercury; nanogold; nanoparticles; oligonucleotides; wavelengths;     Show all 7 Subjects
Abstract:
... We demonstrated a sensitive method for detection of glutathione (GSH) based on LSPR scattering spectrum using gold core-satellite nanostructure linked by T-Hg2+-T base pair. The core-satellite assembly caused coupling between plasmonic nanoparticles, which inducing distinct change of LSPR peak wavelength. As the interaction between Hg2+ and GSH, the core-satellite nanostructure would be disassembl ...
DOI:
10.1016/j.talanta.2018.09.096

5. A new substrate for glutathione reductase: Glutathione coated Ag2S quantum dots

Author:
Aydemir, Duygu; Hashemkhani, Mahshid; Durmusoglu, Emek G.; Acar, Havva Yagci; Ulusu, Nuriye Nuray
Source:
Talanta 2019 v.194 pp. 501-506
ISSN:
0039-9140
Subject:
glutathione; glutathione-disulfide reductase,   etc   ; antioxidants; cell proliferation; coatings; enzyme activity; luminescence; oxidation; oxidative stress; quantum dots;     Show all 10 Subjects
Abstract:
... Glutathione (GSH), a key player in various cellular processes including detoxification, anti-oxidant defense system and cell proliferation is also a potentially good coating material for luminescent quantum dots. GSH is oxidized to oxidized glutathione (GSSG) under oxidative stress and then reduced back by glutathione reductase (GR) enzyme to maintain the balance of GSH/GSSG ratio. In this frame, ...
DOI:
10.1016/j.talanta.2018.10.049

6. Enzymatic glutaredoxin-dependent method to determine glutathione and protein S-glutathionylation using fluorescent eosin-glutathione

Author:
Coppo, Lucia; Ogata, Fernando T.; Santhosh, Sebastin M.; Sventelius, Teodor; Holmgren, Arne
Source:
Analytical biochemistry 2019 v.568 pp. 24-30
ISSN:
0003-2697
Subject:
glutathione; glutathione-disulfide reductase,   etc   ; NADP (coenzyme); clinical trials; fluorescence; mammals; post-translational modification; proteins; thiols; tissues;     Show all 10 Subjects
Abstract:
... Glutathione is an abundant low-molecular-weight thiol, up to 10 mM in mammalian cells, and exists in three major forms: reduced sulphydryl (GSH), glutathione disulfide (GSSG) or bound to Cys residues in proteins (PSSG). The ratio GSH/GSSG has been used as an indicator of the cells redox level but this parameter can also be estimated by the quantification of PSSG. In fact, PSSGs have the advantage ...
DOI:
10.1016/j.ab.2018.12.021

7. Bioaccumulation and detoxication of microcystin-LR in three submerged macrophytes: The important role of glutathione biosynthesis

Author:
Cao, Qing; Wan, Xiang; Shu, Xiubo; Xie, Liqiang
Source:
Chemosphere 2019 v.225 pp. 935-942
ISSN:
0045-6535
Subject:
glutathione; glutathione transferase; glutathione-disulfide reductase,   etc   ; Ceratophyllum demersum; Cyanobacteria; Myriophyllum spicatum; Vallisneria; bioaccumulation; biosynthesis; biotransformation; eutrophication; macrophytes; malondialdehyde; microcystin-LR; surface water; toxicity;     Show all 16 Subjects
Abstract:
... Aquatic plants naturally come into direct contact with microcystins in eutrophic water bodies suffering from cyanobacteria blooms. In the present study, the bioaccumulation and detoxification of microcystin-LR (MC-LR) in three submerged macrophytes, Ceratophyllum demersum L., Vallisneria natans (Lour.) Hara and Myriophyllum spicatum L., were investigated. Our results showed that the average daily ...
DOI:
10.1016/j.chemosphere.2019.03.055

8. Red tide dinoflagellate Cochlodinium polykrikoides induces significant oxidative stress and DNA damage in the gill tissue of the red seabream Pagrus major

Author:
Shin, Yun Kyung; Nam, Sang-Eun; Kim, Won Jin; Seo, Do Yeon; Kim, Youn-Jung; Rhee, Jae-Sung
Source:
Harmful algae 2019 v.86 pp. 37-45
ISSN:
1568-9883
Subject:
glutathione; glutathione peroxidase; glutathione-disulfide reductase,   etc   ; Cochlodinium; DNA damage; Pagrus major; algal blooms; antioxidant activity; aquaculture; catalase; fisheries; malondialdehyde; oxidative stress; poisonous algae; respiratory rate; superoxide dismutase; tissues;     Show all 17 Subjects
Abstract:
... The ichthyotoxic Cochlodinium polykrikoides is one of the most harmful bloom-forming dinoflagellates. In the present study, the economically important red seabream Pagrus major was exposed to sublethal concentrations of C. polykrikoides (i.e., 1,000 and 3,000 cells mL−1) for 24 h, and the antioxidant defense system and DNA damage dose-specific responses were analyzed during the exposure and additi ...
DOI:
10.1016/j.hal.2019.04.008

9. Cadmium-induced oxidative stress in Prussian carp (Carassius gibelio Bloch) hepatopancreas: ameliorating effect of melatonin

Author:
Drąg-Kozak, Ewa; Pawlica-Gosiewska, Dorota; Gawlik, Katarzyna; Socha, Magdalena; Gosiewski, Grzegorz; Łuszczek-Trojnar, Ewa; Solnica, Bogdan; Popek, Włodzimierz
Source:
Environmental science and pollution research international 2019 v.26 no.12 pp. 12264-12279
ISSN:
0944-1344
Subject:
glutathione; glutathione peroxidase; glutathione-disulfide reductase,   etc   ; Carassius gibelio; antioxidants; cadmium; copper; enzyme activity; exposure duration; females; fish; hepatopancreas; iron; melatonin; oxidative stress; superoxide dismutase; tissues; toxicity; zinc;     Show all 19 Subjects
Abstract:
... The oxidative status of the hepatopancreas of Prussian carp females (Carassius gibelio) co-exposed to sublethal cadmium in water and melatonin was studied. The activities of antioxidant enzymes such as glutathione reductase (GR), glutathione peroxidase (GPx), and superoxide dismutase (SOD) as well as the concentration of reduced glutathione (GSH) were measured in homogenates of the hepatopancreas. ...
DOI:
10.1007/s11356-019-04595-3

10. The effect of bagging on ascorbate in Pyrus fruit

Author:
Zhang, Hu Ping; Qin, An; Qi, Kai Jie; Tao, Shu Tian; Wu, Ju You; Huang, Xiao San; Zhang, Shao Ling
Source:
New Zealand journal of crop and horticultural science 2019 v.47 no.1 pp. 19-31
ISSN:
1175-8783
Subject:
glutathione; glutathione dehydrogenase (ascorbate); glutathione-disulfide reductase,   etc   ; Pyrus pyrifolia; ascorbate peroxidase; ascorbic acid; bags; biosynthesis; enzyme activity; flowering; fruits; galactose; gene expression; genes; monodehydroascorbate reductase (NADH);     Show all 15 Subjects
Abstract:
... Here, the L-ascorbic acid (AsA) content as well as activities of enzymes and genes in AsA biosynthesis were investigated in bagged and unbagged fruit of Pyrus pyrifolia ‘Cuiguan’ during on-tree development. The contents of AsA/dehydroascorbate (DHA) and glutathione (γ-glutamyl-L-cysteinylglycine, GSH)/oxidised glutathione (GSSG) couples, the enzyme activities of L-galactono-1,4-lactone dehydrogena ...
DOI:
10.1080/01140671.2018.1462209

11. Overexpression of GmNAC085 enhances drought tolerance in Arabidopsis by regulating glutathione biosynthesis, redox balance and glutathione-dependent detoxification of reactive oxygen species and methylglyoxal

Author:
Nguyen, Kien Huu; Mostofa, Mohammad Golam; Watanabe, Yasuko; Tran, Cuong Duy; Rahman, Md. Mezanur; Tran, Lam-Son Phan
Source:
Environmental and experimental botany 2019 v.161 pp. 242-254
ISSN:
0098-8472
Subject:
glutathione; glutathione peroxidase; glutathione transferase,   etc   ; Arabidopsis thaliana; abiotic stress; adverse effects; aldehydes; biosynthesis; drought; drought tolerance; enzyme activity; gene overexpression; genes; glutathione-disulfide reductase; growth retardation; leaves; messenger RNA; oxidative stress; soybeans; toxicity; transcription factors; transgenic plants;     Show all 22 Subjects
Abstract:
... Glutathione (GSH)-dependent detoxification mechanisms are crucial for protecting plants from the adverse effects of abiotic stresses, including drought. Plant tolerance to drought is regulated by a set of transcription factors that are considered as an integral part of signaling networks in plants. Recently, there have been excellent appreciations on the drought tolerance roles of NAC (NAM, ATAF1/ ...
DOI:
10.1016/j.envexpbot.2018.12.021

12. Developing chemically modified redox-responsive proteins as smart therapeutics

Author:
TangQ. Tang and J. X. Wang contributed equally., Qiao; Wang, Jianxue; Jiang, Ying; Zhang, Meining; Chang, Jin; Xu, Qiaobing; Mao, Lanqun; Wang, Ming
Source:
Chemical communications 2019 v.55 no.35 pp. 5163-5166
ISSN:
1364-548X
Subject:
glutathione,   etc   ; aqueous solutions; chemical reactions; ligands; neoplasms; proteins; ribonucleases; therapeutics;     Show all 8 Subjects
Abstract:
... The conditional control of protein function in response to the physiological changes of diseased cells is essential to develop smart protein therapeutics. Herein, we report a redox-responsive chemical modification of a protein by conjugating an intracellular glutathione (GSH)-cleavable ligand, NSA, onto a protein residue. We demonstrated that the NSA conjugation of Ribonuclease A (RNase A) enabled ...
DOI:
10.1039/c9cc00519f

13. The protective role of virgin coconut oil on the alloxan-induced oxidative stress in the liver, kidneys and heart of diabetic rats

Author:
Đurašević, Siniša; Jasnić, Nebojša; Prokić, Marko; Grigorov, Ilijana; Martinović, Vesna; Đorđević, Jelena; Pavlović, Slađan
Source:
Food & function 2019 v.10 no.4 pp. 2114-2124
ISSN:
2042-650X
Subject:
glutathione; glutathione peroxidase; glutathione transferase,   etc   ; alloxan; animal disease models; catalase; coconut oil; diabetes; discriminant analysis; enzyme activity; glutathione-disulfide reductase; heart; kidneys; liver; moieties; oxidative stress; protective effect; rats; sulfhydryl groups; superoxide dismutase; tissues;     Show all 21 Subjects
Abstract:
... The aim of this study was to investigate the potential protective effect of virgin coconut oil (VCO) on oxidative stress parameters in the liver, kidneys and heart of alloxan-induced (150 mg kg⁻¹ i.p.⁻¹) diabetes in rats. Our results showed that daily supplementation of VCO (20% of food) for 16 weeks significantly (p < 0.05) ameliorates some deleterious effects caused by alloxan. VCO reduced the d ...
DOI:
10.1039/c9fo00107g

14. Biocompatible N-acetyl cysteine reduces graphene oxide and persists at the surface as a green radical scavenger

Author:
Palmieri, Valentina; Dalchiele, Enrique A.; Perini, Giordano; Motta, Alessandro; De Spirito, Marco; Zanoni, Robertino; Marrani, Andrea Giacomo; Papi, Massimiliano
Source:
Chemical communications 2019 v.55 no.29 pp. 4186-4189
ISSN:
1364-548X
Subject:
glutathione,   etc   ; ambient temperature; cysteine; graphene oxide; oxidation; spectroscopy;     Show all 6 Subjects
Abstract:
... We demonstrate that N-acetyl cysteine (NAC) reduces graphene oxide (GO) at room temperature. This represents a new green method to produce reduced GO (rGO). NAC adheres to the rGO surface as demonstrated by several spectroscopy techniques and avoids GO-mediated oxidation of glutathione. This method offers new opportunities for the production of green biocompatible rGO and NAC-based therapies. ...
DOI:
10.1039/c9cc00429g

15. Limited oxidative stress in common carp (Cyprinus carpio, L., 1758) exposed to a sublethal tertiary (Cu, Cd and Zn) metal mixture

Author:
Pillet, M.; Castaldo, G.; De Weggheleire, S.; Bervoets, L.; Blust, R.; De Boeck, G.
Source:
Comparative biochemistry and physiology 2019 v.218 pp. 70-80
ISSN:
1532-0456
Subject:
glutathione; glutathione peroxidase; glutathione transferase,   etc   ; Cyprinus carpio; antioxidant activity; apoptosis; cadmium; caspase-9; catalase; copper; defense mechanisms; ecosystems; enzyme activity; free radicals; genes; gills; glutathione-disulfide reductase; liver; malondialdehyde; oxidative stress; pollution; risk; superoxide dismutase; transcription (genetics); xanthine oxidase; zinc;     Show all 26 Subjects
Abstract:
... Analyzing effects of metal mixtures is important to obtain a realistic understanding of the impact of mixed stress in natural ecosystems. The impact of a one-week exposure to a sublethal metal mixture containing copper (4.8 μg/L), cadmium (2.9 μg/L) and zinc (206.8 μg/L) was evaluated in the common carp (Cyprinus carpio). To explore whether this exposure induced oxidative stress or whether defense ...
DOI:
10.1016/j.cbpc.2019.01.003

16. Alcesefoliside protects against oxidative brain injury in rats

Author:
Simeonova, Rumyana; Vitcheva, Vessela; Kondeva-Burdina, Magdalena; Popov, Georgi; Shkondrov, Aleksandar; Manov, Vassil; Krasteva, Ilina
Source:
Revista Brasileira de Farmacognosia 2019 v.29 no.2 pp. 221-227
ISSN:
0102-695X
Subject:
glutathione; glutathione peroxidase; glutathione transferase,   etc   ; Astragalus monspessulanus; acetylcholinesterase; antioxidants; ascorbic acid; biomarkers; brain; brain damage; carbon tetrachloride; catalase; glutathione-disulfide reductase; histopathology; laboratory animals; lipid peroxidation; males; malondialdehyde; microsomes; neuroprotective effect; oxidative stress; rats; silymarin; sulfates; superoxide dismutase; toxicity;     Show all 26 Subjects
Abstract:
... This study investigated the possible antioxidant and neuroprotective effects of alcesefoliside, isolated from Astragalus monspessulanus L., Fabaceae, against carbon tetrachloride (CCl4)-induced brain injury in Wistar rats. Iron sulphate/ascorbic acid lipid peroxidation was induced in rat brain microsomes and pre-incubated with alcesefoliside and silybin. Male rats were treated in vivo with alcesef ...
DOI:
10.1016/j.bjp.2018.10.002

17. Design, Synthesis, and Cellular Uptake of Oligonucleotides Bearing Glutathione-Labile Protecting Groups

Author:
Saneyoshi, Hisao; Ohta, Takayuki; Hiyoshi, Yuki; Saneyoshi, Takeo; Ono, Akira
Source:
Organic letters 2019 v.21 no.4 pp. 862-866
ISSN:
1523-7052
Subject:
glutathione,   etc   ; chemical reactions; intracellular fluids; models; moieties; oligonucleotides; organic compounds;     Show all 7 Subjects
Abstract:
... Glutathione-labile protecting groups for phosphodiester moieties in oligonucleotides were designed, synthesized, and incorporated into oligonucleotides. The protecting groups on the phosphodiester moieties were cleaved in a buffer containing 10 mM glutathione, which was used as a model of intracellular fluid. Cellular uptake of oligonucleotides bearing glutathione-labile protecting groups was stro ...
DOI:
10.1021/acs.orglett.8b03501

18. An electroanalysis strategy for glutathione in cells based on the displacement reaction route using melamine-copper nanocomposites synthesized by the controlled supermolecular self-assembly

Author:
Hua, Yue; Liu, Min; Li, Shuai; Liu, Fengjuan; Cai, Yuanyuan; Liu, Huan; Wan, Yuqi; Lv, Xiaoxia; Wang, Hua
Source:
Biosensors & bioelectronics 2019 v.124-125 pp. 89-95
ISSN:
0956-5663
Subject:
glutathione,   etc   ; biosensors; electrochemistry; electrodes; food analysis; nanocomposites; yeasts;     Show all 7 Subjects
Abstract:
... An electroanalysis strategy has been developed for probing glutathione (GSH) separately in hela and yeast cells based on the displacement reaction route using melamine-copper (MA-Cu) nanocomposites. Herein, MA-Cu nanocomposites were initially synthesized by the controlled supermolecular self-assembly process showing various morphological structures depending on the MA-to-Cu ratios used. It was dis ...
DOI:
10.1016/j.bios.2018.10.022

19. Response of the antioxidant enzymes of rats following oral administration of metal-oxide nanoparticles (Al2O3, CuO, TiO2)

Author:
Canli, Esin G.; Ila, Hasan B.; Canli, Mustafa
Source:
Environmental science and pollution research international 2019 v.26 no.1 pp. 938-945
ISSN:
0944-1344
Subject:
glutathione; glutathione peroxidase; glutathione transferase,   etc   ; Rattus norvegicus; aluminum; aluminum oxide; antioxidants; catalase; copper; copper nanoparticles; cupric oxide; ecotoxicology; enzyme activity; females; glutathione-disulfide reductase; liver; oral administration; rats; superoxide dismutase; titanium; titanium dioxide; transmission electron microscopes; transmission electron microscopy;     Show all 23 Subjects
Abstract:
... Metal-oxide nanoparticles (NPs), as a new emerging technological compound, promise a wide range of usage areas and consequently have the potential to cause environmental toxicology. In the present work, aluminum (Al₂O₃), copper (CuO), and titanium (TiO₂) nanoparticles (NPs) were administered via oral gavage to mature female rats (Rattus norvegicus var. albinos) for 14 days with a dose series of 0 ...
DOI:
10.1007/s11356-018-3592-8

20. Tools for non-invasive sampling of metal accumulation and its effects in Mediterranean pond turtle populations inhabiting mining areas

Author:
Ortiz-Santaliestra, Manuel E.; Rodríguez, Antonio; Pareja-Carrera, Jennifer; Mateo, Rafael; Martinez-Haro, Mónica
Source:
Chemosphere 2019 v.231 pp. 194-206
ISSN:
0045-6535
Subject:
glutathione; glutathione peroxidase,   etc   ; Emydidae; Mauremys; antioxidants; bioaccumulation; blood; feces; lead; longevity; mercury; mining; monitoring; oxidative stress; pollution; toxicity; turtles;     Show all 17 Subjects
Abstract:
... Among reptiles, freshwater turtle species have high potential for metal accumulation because of their long lifespan or their aquatic and terrestrial habits. In order to monitor metal bioaccumulation, determine potential toxic effects, and investigate tools for non-invasive metal sampling in reptiles, we studied lead (Pb) and mercury (Hg) accumulation in Mediterranean pond turtles (Mauremys leprosa ...
DOI:
10.1016/j.chemosphere.2019.05.082