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1. Construction of a microfluidic platform integrating online protein fractionation, denaturation, digestion, and peptide enrichment

Author:
Wei, Ze-Hui; Zhang, Xue; Zhao, Xue; Jiao, Ya-Jie; Huang, Yan-Ping; Liu, Zhao-Sheng
Source:
Talanta 2021 v.224 pp. 121810
ISSN:
0039-9140
Subject:
glycine (amino acid),   etc   ; allyl compounds; batch systems; betaine; enzymatic hydrolysis; fractionation; immobilized enzymes; microfluidic technology; peptides; post-translational modification; protein denaturation; proteomics; reversed-phase liquid chromatography; ubiquitin;     Show all 14 Subjects
Abstract:
... Microfluidic system with multi-functional integration of high-throughput protein/peptide separation ability has great potential for improving the identification capacity of biological samples in proteomics. In this paper, a sample treatment platform was constructed by integrating reversed phase chromatography, immobilized enzyme reactor (IMER) and imprinted monolith through a microfluidic chip to ...
DOI:
10.1016/j.talanta.2020.121810

2. Designing novel biocompatible oligopeptide-based ionic liquids for greener downstream processes

Author:
Morandeira, Lois; Martínez-Baltasar, Alberto; Sanromán, M Ángeles; Rodríguez, Ana; Deive, Francisco J.
Source:
Journal of cleaner production 2021 v.279 pp. 123356
ISSN:
0959-6526
Subject:
glycine (amino acid),   etc   ; Tetraselmis suecica; alpha-tocopherol; beta-carotene; biodegradability; biorefining; cations; chlorophyll; choline; dipeptides; industry; ionic liquids; microalgae; models; surfactants; tripeptides;     Show all 16 Subjects
Abstract:
... In this work, a new family of ILs is here firstly presented, built with the biocompatible and biodegradable choline cation and oligopeptide-based anion. The simplest tripeptide triglycine (Gly-Gly-Gly) was employed for conforming a new choline tripeptide (Ch3Pe) IL, which sets the foundations for novel families of ILs based on peptides. Aiming at exploring the applicability of the novel solvents, ...
DOI:
10.1016/j.jclepro.2020.123356

3. Evaluation of branched-chain amino acids in male Cobb MV × 500 broiler chickens by using Box-Behnken response surface design

Author:
Maynard, C.W.; Liu, S.Y.; Lee, J.T.; Caldas, J.V.; Diehl, J.J.E.; Rochell, S.J.; Kidd, M.T.
Source:
Animal feed science and technology 2021 v.271 pp. 114710
ISSN:
0377-8401
Subject:
glycine (amino acid),   etc   ; body weight; branched chain amino acids; breast meat; breasts; broiler chickens; carcass characteristics; data analysis; experimental design; experimental diets; feed conversion; feed intake; isoleucine; leucine; limiting amino acids; lysine; males; serine; valine;     Show all 19 Subjects
Abstract:
... Data pertaining to the branched-chain amino acids (BCAA) are of particular importance due to the positioning of valine (Val) and isoleucine (Ile) as limiting amino acids (AA) in conventional diets. Similarly, current research evaluating their potential interaction is sparse. Therefore, two experiments were conducted using Box-Behnken design (BBD) to determine performance and carcass responses to B ...
DOI:
10.1016/j.anifeedsci.2020.114710

4. Supplementation of glycine, prebiotic, and nucleotides in soybean meal-based diets for largemouth bass (Micropterus salmoides): Effects on production performance, whole-body nutrient composition and retention, and intestinal histopathology

Author:
Rossi, Waldemar; Allen, Kristy M.; Habte-Tsion, Habte-Michael; Meesala, Kala-Mallik
Source:
Aquaculture 2021 v.532 pp. 736031
ISSN:
0044-8486
Subject:
glycine (amino acid),   etc   ; Micropterus salmoides; additives; alkaline phosphatase; aquariums; aspartic acid; crude protein; enteritis; enterocytes; enzyme activity; experimental diets; feed conversion; fish; fish meal; glass; glutathione peroxidase; growth performance; histopathology; ingredients; isoleucine; lipid content; lipids; liver; malondialdehyde; nucleotides; nutrient content; nutrients; phenylalanine; plant-based diet; prebiotics; proline; recirculating aquaculture systems; soybean meal; soybeans; superoxide dismutase; valine; weight gain; wheat flour;     Show all 38 Subjects
Abstract:
... Aiming to optimize plant-based diets for largemouth bass (LMB; Micropterus salmoides), a 10-week feeding trial was conducted to evaluate effects of supplemental glycine, prebiotic, and nucleotides in soybean meal (SBM)-based diets formulated to contain 50% SBM, 40% crude protein, and 12% lipid. Four test diets were formulated by supplementing glycine at 2% (GLY), GroBiotic®-A at 2% (GBA), a nucleo ...
DOI:
10.1016/j.aquaculture.2020.736031

5. Transcriptomic and physiological analyses of hepatopancreas reveal the key metabolic changes in response to dietary copper level in Pacific white shrimp Litopenaeus vannamei

Author:
Shi, Bo; Yuan, Ye; Jin, Min; Betancor, Mónica B.; Tocher, Douglas R.; Jiao, Lefei; Song, Dongying; Zhou, Qicun
Source:
Aquaculture 2021 v.532 pp. 736060
ISSN:
0044-8486
Subject:
glycine (amino acid),   etc   ; Litopenaeus vannamei; aspartic acid; copper; copper sulfate; diet; essential amino acids; gene expression; gene expression regulation; genes; growth and development; hepatopancreas; immune system; interleukin-17; isoleucine; leucine; lysine; metabolism; methionine; phagosomes; proline; serine; shrimp; signal transduction; tissues; transcriptome; transcriptomics; tyrosine; valine; weight gain;     Show all 30 Subjects
Abstract:
... All living organisms require copper for growth and development, but the gene expression profiles and molecular mechanisms underpinning dietary copper are poorly investigated. Therefore, the present study aimed to determine the potential metabolic changes in response to dietary copper based on analysis of hepatopancreas transcriptome in Litopenaeus vannamei. Three practical diets were formulated to ...
DOI:
10.1016/j.aquaculture.2020.736060

6. Integration of metabolomics and proteomics to highlight altered neural development related pathways in the adult offspring after maternal folic acid supplement

Author:
Liu, Liyan; Liu, Zhipeng; Li, Ying; Sun, Changhao
Source:
Clinical nutrition 2021 v.40 no.2 pp. 476-487
ISSN:
0261-5614
Subject:
glycine (amino acid),   etc   ; G-proteins; adults; arachidonic acid; blood sampling; blood serum; brain; diet; docosahexaenoic acid; early development; females; folic acid; gamma-aminobutyric acid; humans; ingestion; linoleic acid; lysophosphatidylcholine; memory; metabolism; metabolites; metabolomics; neurodevelopment; progeny; proteomics; rats; synapse; tandem mass spectrometry; tryptophan; ultra-performance liquid chromatography;     Show all 29 Subjects
Abstract:
... Maternal folic acid (FA) supplement (FolS) programs the early development of an offspring. The onset of complex diseases at a later stage of life has been evidently linked with maternal FA ingestion. However, little is known regarding the underlying molecule fingerprints of the offspring. Here, we analyze the influence of maternal FolS on the metabolism of the adult offspring rats using the integr ...
DOI:
10.1016/j.clnu.2020.05.042

7. Heat stress alters muscle protein and amino acid metabolism and accelerates liver gluconeogenesis for energy supply in broilers

Author:
Ma, Bingbing; Zhang, Lin; Li, Jiaolong; Xing, Tong; Jiang, Yun; Gao, Feng
Source:
Poultry science 2021 v.100 no.1 pp. 215-223
ISSN:
0032-5791
Subject:
glycine (amino acid),   etc   ; amino acid metabolism; average daily gain; blood serum; breast muscle; corticosterone; energy; enzymes; feed intake; gene expression; genes; gluconeogenesis; growth performance; heat stress; liver; lysine; messenger RNA; muscle protein; muscle tissues; muscular atrophy; ribosomal proteins; solutes; threonine; tyrosine;     Show all 24 Subjects
Abstract:
... Heat stress impairs growth performance and alters body protein and amino acid metabolism. This study was investigated to explore how body protein and amino acid metabolism changed under heat stress (HS) and the stress adaptation mechanism. A total of 144 broilers (28 d old) were divided into 3 treatment groups for 1 wk: HS group (32°C), normal control group (22°C), and pair-feeding group (22°C). W ...
DOI:
10.1016/j.psj.2020.09.090

8. Low crude protein diets for broiler chickens aged 8 to 21 days should have a 50% essential-to-total nitrogen ratio

Author:
Maia, Rosana C.; Albino, Luiz F.T.; Rostagno, Horácio S.; Xavier Junior, Maurílio L.; Kreuz, Bruna S.; Silva, Raully L.; Faria, Bruno D.; Calderano, Arele A.
Source:
Animal feed science and technology 2021 v.271 pp. 114709
ISSN:
0377-8401
Subject:
glycine (amino acid),   etc   ; alanine; albumins; blood; blood composition; body weight changes; broiler chickens; broiler feeding; crude protein; data analysis; excreta; experimental design; feed conversion; feed intake; globulins; glutamic acid; growth performance; low protein diet; males; models; nitrogen; nitrogen retention; uric acid;     Show all 23 Subjects
Abstract:
... The aim of this study was to evaluate the effects of essential-to-total nitrogen (eN-to-tN) ratios supplemented with nonessential amino acids (NEAAs) in low-protein diets on the performance, nitrogen retention and blood parameters of broiler chickens from 8 day to 21 day posthatch. A total of 300 male Cobb® 500 chickens were weighed and allocated to one of six dietary treatments with 10 replicate ...
DOI:
10.1016/j.anifeedsci.2020.114709

9. d-Aspartate N-methyltransferase catalyzes biosynthesis of N-methyl-d-aspartate (NMDA), a well-known selective agonist of the NMDA receptor, in mice

Author:
Shibata, Kimihiko; Imanishi, Daiki; Abe, Katsumasa; Suzuki, Masataka; Takahashi, Shouji; Kera, Yoshio
Source:
Biochimica et biophysica acta 2020 v.1868 no.12 pp. 140527
ISSN:
1570-9639
Subject:
glycine (amino acid),   etc   ; agonists; biosynthesis; catalytic activity; enzyme activity; glycine N-methyltransferase; mice; rats; tissues;     Show all 9 Subjects
Abstract:
... N-Methyl-d-aspartate (NMDA), which is a selective agonist for the NMDA receptor, has recently been shown to be present in various biological tissues. In mammals, the activity of d-aspartate N-methyltransferase (DDNMT), which produces NMDA from d-aspartate, has been detected only in homogenates prepared from rat tissues. Moreover, the enzymatic properties of DDNMT have been poorly studied and its m ...
DOI:
10.1016/j.bbapap.2020.140527

10. A novel quaternary ammonium salts derived from α-amino acids with large steric hindrance group and its application in asymmetric Mannich reaction

Author:
Tian, Zhengtao; Meng, Xiangyu; Luo, Yueyang; Cao, Shaokui; Zhao, Gang
Source:
Tetrahedron 2020 v.76 no.39 pp. 131484
ISSN:
0040-4020
Subject:
glycine (amino acid),   etc   ; ammonium salts; catalysts; chemical reactions; chemical structure; imines; quaternary ammonium compounds;     Show all 7 Subjects
Abstract:
... Quaternary ammonium salts derived from amino acids with large steric hindrance group have been designed and synthesized, which promoted the asymmetric Mannich reaction of glycine imines with N-Boc-aldimines in excellent yields with high enantio- and diastereo-control compared with known catalysts of this type reported by our group. ...
DOI:
10.1016/j.tet.2020.131484

11. Quantitative analysis of glycine related metabolic pathways for one-carbon synthetic biology

Author:
Hong, Yaeseong; Ren, Jie; Zhang, Xinyi; Wang, Wei; Zeng, An-Ping
Source:
Current opinion in biotechnology 2020 v.64 pp. 70-78
ISSN:
0958-1669
Subject:
glycine (amino acid),   etc   ; biochemical pathways; folic acid; metabolic engineering; metabolism; metabolites; quantitative analysis; synthetic biology;     Show all 8 Subjects
Abstract:
... Glycine is an essential one-carbon (C1) metabolite nested in a complex network of cellular metabolism. Glycine and its related metabolic pathways have important biochemical and biomedical implications and have thus been studied for a long time. However, quantitative and systems level knowledge about the interactions and regulations of the pathways are severely limited, especially for the purpose o ...
DOI:
10.1016/j.copbio.2019.10.001

12. Liposomal delivery of functional transmembrane ion channels into the cell membranes of target cells; a potential approach for the treatment of channelopathies

Author:
Ramadan, Shahenda; Tammam, Salma N.; Shetab Boushehri, Maryam A.; Breitinger, Hans-Georg; Breitinger, Ulrike; Mansour, Samar; Lamprecht, Alf
Source:
International journal of biological macromolecules 2020 v.153 pp. 1080-1089
ISSN:
0141-8130
Subject:
glycine (amino acid),   etc   ; cell membranes; cholesterol; fibroblasts; glycine receptors; human cell lines; ion channels; lecithins; models;     Show all 9 Subjects
Abstract:
... Defects in transmembrane ion channels underlie many disorders, commonly known as channelopathies. Current therapies are mostly symptomatic and do not treat the underlying cause. Here, we demonstrate the delivery of functional ion channels in protein form into the membrane of target cells using fusogenic proteoliposomes. The glycine receptor (GlyR) was adopted as a model channel. HEK293 cells were ...
DOI:
10.1016/j.ijbiomac.2019.10.238

13. NBCZone: Universal three-dimensional construction of eleven amino acids near the catalytic nucleophile and base in the superfamily of (chymo)trypsin-like serine fold proteases

Author:
Denesyuk, Alexander I.; Johnson, Mark S.; Salo-Ahen, Outi M.H.; Uversky, Vladimir N.; Denessiouk, Konstantin
Source:
International journal of biological macromolecules 2020 v.153 pp. 399-411
ISSN:
0141-8130
Subject:
glycine (amino acid),   etc   ; catalytic activity; cysteine proteinases; disulfide bonds; eukaryotic cells; prokaryotic cells; serine; viruses;     Show all 8 Subjects
Abstract:
... (Chymo)trypsin-like serine fold proteases belong to the serine/cysteine proteases found in eukaryotes, prokaryotes, and viruses. Their catalytic activity is carried out using a triad of amino acids, a nucleophile, a base, and an acid. For this superfamily of proteases, we propose the existence of a universal 3D structure comprising 11 amino acids near the catalytic nucleophile and base – Nucleophi ...
DOI:
10.1016/j.ijbiomac.2020.03.025
PubMed:
32151723
PubMed Central:
PMC7124590

14. Photoluminescence, TGA/DSC and photocatalytic activity studies of Dy³⁺ doped SrY₂O₄ nanophosphors

Author:
Ghorpade, Santosh P.; Kottam, Nagaraju; Melavanki, Raveendra; Patil, N. R.
Source:
RSC advances 2020 v.10 no.36 pp. 21049-21056
ISSN:
2046-2069
Subject:
glycine (amino acid),   etc   ; combustion; differential scanning calorimetry; dysprosium; energy; fuels; photocatalysis; photoluminescence; thermal properties; thermogravimetry;     Show all 10 Subjects
Abstract:
... Dy³⁺:SrY₂O₄ nanophosphors were prepared via a solution combustion method using glycine as an organic fuel. The structural, optical, and thermal properties of the nanophosphors were studied. Strain and crystal size were calculated via W–H analysis. The direct energy band gap is nearly 4.9 eV and photocatalytic studies reveal that Rh-B degradation of almost 50% can be achieved. ...
DOI:
10.1039/d0ra03094e

15. Optimized bioleaching of copper by indigenous cyanogenic bacteria isolated from the landfill of e-waste

Author:
Arab, Bahareh; Hassanpour, Fatemeh; Arshadi, Mahdokht; Yaghmaei, Soheila; Hamedi, Javad
Source:
Journal of environmental management 2020 v.261 pp. 110124
ISSN:
0301-4797
Subject:
glycine (amino acid),   etc   ; bacteria; bioleaching; copper; cyanides; electronic wastes; landfills; pH; soil; temperature; Iran;     Show all 11 Subjects
Abstract:
... In this study, indigenous cyanogenic bacterial strains were isolated on nutrient, minimal salt, and soil extract media at various culture conditions from two distinct landfills of e-waste, Iran. Based on their cyanide formation profiles, five most potent isolates were selected for optimization and to this end, the influence of the most effective factors on cyanide production including pH, glycine ...
DOI:
10.1016/j.jenvman.2020.110124

16. Bumped Kinase Inhibitors as therapy for apicomplexan parasitic diseases: lessons learned

Author:
Choi, Ryan; Hulverson, Matthew A.; Huang, Wenlin; Vidadala, Rama S.R.; Whitman, Grant R.; Barrett, Lynn K.; Schaefer, Deborah A.; Betzer, Dana P.; Riggs, Michael W.; Doggett, J. Stone; Hemphill, Andrew; Ortega-Mora, Luis Miguel; McCloskey, Molly C.; Arnold, Samuel L.M.; Hackman, Robert C.; Marsh, Kennan C.; Lynch, James J.; Freiberg, Gail M.; Leroy, Bruce E.; Kempf, Dale J.; Choy, Robert K.M.; de Hostos, Eugenio L.; Maly, Dustin J.; Fan, Erkang; Ojo, Kayode K.; Van Voorhis, Wesley C.
Source:
International journal for parasitology 2020 v.50 no.5 pp. 413-422
ISSN:
0020-7519
Subject:
glycine (amino acid),   etc   ; Miozoa; enzyme inhibitors; parasitoses; pharmacology; protein kinases; therapeutics;     Show all 7 Subjects
Abstract:
... Bumped Kinase Inhibitors, targeting Calcium-dependent Protein Kinase 1 in apicomplexan parasites with a glycine gatekeeper, are promising new therapeutics for apicomplexan diseases. Here we will review advances, as well as challenges and lessons learned regarding efficacy, safety, and pharmacology that have shaped our selection of pre-clinical candidates. ...
DOI:
10.1016/j.ijpara.2020.01.006

17. Enhanced production of L-methionine in engineered Escherichia coli with efficient supply of one carbon unit

Author:
Tang, Xiao-Ling; Du, Xu-Yuan; Chen, Lu-Jia; Liu, Zhi-Qiang; Zheng, Yu-Guo
Source:
Biotechnology letters 2020 v.42 no.3 pp. 429-436
ISSN:
0141-5492
Subject:
glycine (amino acid),   etc   ; Escherichia coli; biosynthesis; carbon; enzymes; homocysteine; liquid state fermentation;     Show all 7 Subjects
Abstract:
... OBJECTIVE: L-methionine is an important sulfur-containing amino acid essential for humans and animals. Its biosynthesis pathway is complex and highly regulated. This study aims to explore the bottleneck limiting the improvement of L-methionine productivity and apply efficient strategies to increase L-methionine production in engineered E. coli. RESULTS: The enzyme O-succinylhomoserine sulfhydrylas ...
DOI:
10.1007/s10529-019-02786-z

18. Role of glycine on sulfuric acid-ammonia clusters formation: Transporter or participator

Author:
Li, Danfeng; Chen, Dongping; Liu, Fengyi; Wang, Wenliang
Source:
Journal of environmental sciences (China) 2020 v.89 pp. 125-135
ISSN:
1001-0742
Subject:
glycine (amino acid),   etc   ; ammonia; density functional theory; evaporation; hydrogen bonding; sulfuric acid; temperature;     Show all 7 Subjects
Abstract:
... Glycine (Gly) is ubiquitous in the atmosphere and plays a vital role in new particle formation (NPF). However, the potential mechanism of its on sulfuric acid (SA) - ammonia (A) clusters formation under various atmospheric conditions is still ambiguous. Herein, a (Gly)ₓ·(SA)y·(A)z (z ≤ x + y ≤ 3) multicomponent system was investigated by using density functional theory (DFT) combined with Atmosphe ...
DOI:
10.1016/j.jes.2019.10.009

19. Aspect Ratio Control of Layered Double Hydroxide Nanosheets and Their Application for High Oxygen Barrier Coating in Flexible Food Packaging

Author:
Yu, Jingfang; Buffet, Jean-Charles; O’Hare, Dermot
Source:
ACS applied materials & interfaces 2020 v.12 no.9 pp. 10973-10982
ISSN:
1944-8252
Subject:
glycine (amino acid),   etc   ; coatings; dispersions; food packaging; nanosheets; oxygen; packaging films; polymers;     Show all 8 Subjects
Abstract:
... We report a method to rationally control the aspect ratio of layered double hydroxide for use as a barrier coating for food packaging films. The reconstruction of a Mg₂Al-layered double oxide (LDO) in concentrated aqueous glycine solutions produces dispersions of Mg₂Al-LDH nanosheets. The nanosheet thickness decreases and diameter increases with increasing reconstruction time from 16 to 96 h. We o ...
DOI:
10.1021/acsami.9b21986

20. Visible-Light-Induced Charge Transfer Enables Cₛₚ₃–H Functionalization of Glycine Derivatives: Access to 1,3-Oxazolidines

Author:
Yang, Xiaorong; Zhu, Yin; Xie, Zhixiang; Li, Ying; Zhang, Yuan
Source:
Organic letters 2020 v.22 no.4 pp. 1638-1643
ISSN:
1523-7052
Subject:
glycine (amino acid),   etc   ; catalysts; chemical structure; cycloaddition reactions; organoiodine compounds; oxides; redox reactions; styrene;     Show all 8 Subjects
Abstract:
... A photoredox catalyst free, visible-light-induced aerobic oxidative [2 + 3] cycloaddition reaction between glycine derivatives and styrene oxides has been disclosed that provides an efficient approach for the rapid synthesis of 1,3-oxazolidines under mild conditions. This photoinduced process is enabled by the formation of an electron donor–acceptor complex between glycine derivatives and benzyl i ...
DOI:
10.1021/acs.orglett.0c00234