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... To study new methods to delay the umami taste attenuation of the conditioned pork, the ice temperature of pork, the content of nucleotides, lactic acid, pyruvate, glycogen, and activity of key endogenous enzymes were determined for the conditioned pork stored at 4 °C and ice temperature. The results indicated that the ice temperature of the pork ham bicipital muscle was −1.4 °C. The content of uma ...
glycolysis, etc ; bananas; carotenoids; cultivars; food chemistry; genome; genotype; health promotion; metabolites; metabolomics; pulp; tricarboxylic acid cycle; Show all 12 Subjects
Abstract:
... Banana fruits have attracted considerable attention for health-promoting effects attributed to ubiquitous functional metabolites. However, genotype-dependent accumulation patterns of carotenoids in banana remain largely unclear. Here, we performed a systematic metabolomic investigation of 18 banana cultivars of the AAA, AAB, or ABB genome groups. Our results indicate that the levels of soluble sug ...
... Chiral analysis of food components can provide important information for food quality, bioactivity and safety. Determination of enantiomeric ratios in food is a tedious task, due to the poor resolution and insufficient sensitivity for simultaneous discrimination and quantification of trace amounts of d-form metabolites. Herein, a high-throughput, high-sensitive and high-resolution method was devel ...
glycolysis, etc ; beta oxidation; body weight; climate; environment; exports; fatty acids; females; free fatty acids; glucose; glucose tolerance; heat; heat-shock protein 70; homeostasis; insulin resistance; lipolysis; liver; males; mitochondria; triacylglycerols; Show all 20 Subjects
Abstract:
... Global climate warming has drawn worldwide attention. However, the health impact of heat exposure is still controversial. This study aimed to explore the exact effects and sex differential vulnerability under intermittent heat exposure (IHE) patterns and tried to elucidate the potential mechanisms by which IHE modulated hepatic lipid and glucose homeostasis. Both female and male C57BL/6 N mice wer ...
... This study aims to explore the formation mechanism of ethyl acetate and organic acids in acid rice soup (rice-acid soup) inoculated with Kluyveromyces marxianus L1-1 through the complementary analysis of transcriptome and proteome. The quantity of K. marxianus L1-1 varied significantly in the fermentation process of rice-acid soup and the first and third days were the two key turning points in the ...
... The muscle quality of farmed fish has attracted widespread public attention. To understand a comprehensive molecular mechanism underlying the effects of artificial formula feed- (AF) and grass-feeding (GF) on muscle quality and growth of grass carp (Ctenopharyngodon idellus), muscular transcriptomics and proteomics of GF and AF C. idellus were characterized. A total of 834 DEGs (484 up-, 350 down- ...
... Aerobic glycolysis, or the Warburg effect, is regarded as a critical part of metabolic reprogramming and plays a crucial role in the occurrence and development of tumours. Ubiquitination and deubiquitination, essential post-translational modifications, have attracted increasing attention with regards to the regulation of metabolic reprogramming in cancer. However, the mechanism of ubiquitination i ...
glycolysis, etc ; apoptosis; cell proliferation; hepatoma; humans; Show all 5 Subjects
Abstract:
... Circular RNAs (circRNAs) have previously been confirmed to function as vital regulators in multiple human cancers, including hepatocellular carcinoma (HCC). This study aimed to clarify the role and underlying molecular mechanisms of circ-CFH in HCC. circ-CFH was overexpressed in HCC tissues and cells, and the downregulation of circ-CFH inhibited the development of HCC by repressing cell proliferat ...
glycolysis, etc ; Fourier transform infrared spectroscopy; wastes; Show all 3 Subjects
Abstract:
... The degradation of two poly(ethylene terephtalate) (PET) samples from urban and marine wastes (PET-u and PET-m, respectively) has been studied by comparing their properties with those of virgin PET (PET-v) and post-condensed PET for bottle fabrication (PET-ssp). FTIR spectroscopy, DSC analysis, WCA and MFI results have confirmed that all PET residues were degraded. Therefore, the chemical recyclin ...
glycolysis, etc ; brain; energy; exercise; systematic review; Show all 5 Subjects
Abstract:
... Background. Biological factors are ultimately responsible for the cessation of effort in short, maximal glycolytic efforts. However, how these factors are sensed by the brain and act in a loop or feedforward way to regulate the distribution of effort is still unclear. Methods: A systematic review of existing literature on short term glycolytic exercise has been performed on publicly available data ...
glycolysis, etc ; analytical chemistry; energy; fluorescent dyes; glucose; Show all 5 Subjects
Abstract:
... As a significant energy source for living systems, the aberrant cellular glucose uptake is seriously implicated in numerous metabolic diseases. Unfortunately, current shortage of robust tools leaves the limitation to understand its precise biology. Herein we presented a bioorthogonal light-up fluorescent probe consist of two reagents, Glu-HT-Me+AzGlu2, for rapidly responsive (within 25 min), highl ...
glycolysis, etc ; byproducts; homeostasis; reactive oxygen species; therapeutics; Show all 5 Subjects
Abstract:
... Reactive oxygen species (ROS) are not just a by‐product of cellular metabolic processes but act as signalling molecules that regulate both physiological and pathophysiological processes. A close connection exists in cells between redox homeostasis and cellular metabolism. In this review, we describe how intracellular redox state and glycolytic intermediary metabolism are closely coupled. On the on ...
glycolysis, etc ; T-lymphocytes; carbon; glycogen; memory; phosphorylase; phosphorylation; Show all 7 Subjects
Abstract:
... Zhang et al. (2022) show that TCR signaling promotes the phosphorylation and activation of glycogen phosphorylase B (PYGB) in CD8⁺ memory T (Tmem) cells. PYGB-dependent glycogen mobilization provides a carbon source to support glycolysis and early Tmem cell recall responses. ...
Jia-Xuan Yan; Qihao Wu; Eric J. N. Helfrich; Marc G. Chevrette; Doug R. Braun; Heino Heyman; Gene E. Ananiev; Scott R. Rajski; Cameron R. Currie; Jon Clardy; Tim S. Bugni
glycolysis, etc ; Bacillus (bacteria); antibacterial properties; biochemical pathways; bioinformatics; Show all 5 Subjects
Abstract:
... Chemical investigations of a marine sponge-associated Bacillus revealed six new imidazolium-containing compounds, bacillimidazoles A–F (1–6). Previous reports of related imidazolium-containing natural products are rare. Initially unveiled by timsTOF (trapped ion mobility spectrometry) MS data, extensive HRMS and 1D and 2D NMR analyses enabled the structural elucidation of 1–6. In addition, a plaus ...
glycolysis, etc ; acidification; brain; evolution; glioma; nanosilver; pH; resection; Show all 8 Subjects
Abstract:
... Glioma is one of the most common intracranial malignant tumors worldwide. Since the glioma is invasive and lacks a clear boundary with normal brain tissue, the neurosurgeon can only determine the extent of surgical resection based on empirical experience. Thus, accurately demarcating its boundaries has become a major challenge for surgeons. Owing to the high glycolysis metabolism of glioma cells, ...
glycolysis, etc ; apoptosis; cell proliferation; chemistry; microRNA; stomach neoplasms; therapeutics; Show all 7 Subjects
Abstract:
... Recent researches indicate the key role of circRNA in gastric cancer (GC) progression. However, the role of circ_0026359 in GC progression remains unclear. This study aims to analyze the role of circ_0026359 in GC development and the underlying mechanism. The results showed that compared with controls, GC tissues and cells displayed high circ_0026359 and HOXA9 expression, and low miR-140-3p expres ...
glycolysis, etc ; dephosphorylation; humans; hypoxia; macrophages; microRNA; oxygen; phosphorylation; threonine; Show all 9 Subjects
Abstract:
... Human macrophages infiltrating hypoxic regions alter their metabolism, because oxygen becomes limited. Increased glycolysis is one of the most common cellular adaptations to hypoxia and mostly is regulated via hypoxia-inducible factor (HIF) and RAC-alpha serine/threonine–protein kinase (Akt) signaling, which gets activated under reduced oxygen content. We noticed that micro RNA (miR)-193a-3p enhan ...
glycolysis, etc ; Corynebacterium glutamicum; Pseudomonas stutzeri; biopharmaceuticals; biotechnology; guidelines; metabolites; Show all 7 Subjects
Abstract:
... Ectoine is a high-value protective and stabilizing agent with different applications in biopharmaceuticals, biotechnology, and fine chemicals. Here, efficient production of ectoine in Corynebacterium glutamicum was achieved by combination of metabolic engineering and plug-in repressor library strategy. First, the ectBAC cluster from Pseudomonas stutzeri was introduced into strain K02, and the tite ...
glycolysis, etc ; catalysts; death; glycation; glycosylation; lysine; micelles; pathogenesis; synaptic transmission; Show all 9 Subjects
Abstract:
... Parkinson’s disease (PD) is one of the most prevalent neurodegenerative disorders affecting the worldwide population. One of its hallmarks is the intraneuronal accumulation of insoluble Lewy bodies (LBs), which cause the death of dopaminergic neurons. α-Synuclein (αS) is the main component of these LBs and in them, it commonly contains non-enzymatic post-translational modifications, such as those ...
glycolysis, etc ; central nervous system; energy; glucose; glycogen; lactic acid; pathophysiology; Show all 7 Subjects
Abstract:
... Lactate was initially thought of as a fatigue substance. In recent years, however, lactate not only functions as an energy carrier and contributes to ATP production, but also its role as a signal transmitter has been attracting attention due to the identification of lactate receptors. Lactate is synthesized from glucose and glycogen through the glycolytic system. The central nervous system is a ma ...