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1. On the irrationality of rational design of an HIV vaccine in light of protein intrinsic disorder

Author:
Uversky, Vladimir N.
Source:
Archives of virology 2021 v.166 no.5 pp. 1283-1296
ISSN:
0304-8608
Subject:
glycoproteins,   etc   ; glycosylation; humans; mutation; vaccine development; vaccines; virology;     Show all 7 Subjects
Abstract:
... The lack of progress in finding an efficient vaccine for a human immunodeficiency virus (HIV) is daunting. In fact, this search has spanned nearly four decades without much success. There are several objective reasons for such a failure, which include the highly glycosylated nature of HIV-1, the presence of neotopes, and high mutation rates. This article argues that the presence of highly flexible ...
DOI:
10.1007/s00705-021-04984-5

2. Functionalized polyoxometalate microspheres ensure selective adsorption of phosphoproteins and glycoproteins

Author:
Xu, Wang; Cao, Jian-Fang; Lin, Yan-Na; Shu, Yang; Wang, Jian-Hua
Source:
Chemical communications 2021 v.57 no.27 pp. 3367-3370
ISSN:
1364-548X
Subject:
glycoproteins,   etc   ; adsorption; boronic acids; hydrophilicity; microparticles; phosphates; phosphoproteins; polysaccharides;     Show all 8 Subjects
Abstract:
... Lacunary polyoxometalate (POM), [PW₉O₃₄]⁹⁻, grafts with a boronic acid group attached via an organosilane bridge assemble into microspheres, PW₉–Si–APBA. The oxygen-rich and hydrophilic surface of POM facilitates the binding of phosphate groups in phosphoproteins and glycans in glycoproteins. While the metal–oxo in POM provides π–π interactions with the phosphate groups of phosphoproteins, the bor ...
DOI:
10.1039/d1cc00325a

3. Mesoporous Graphitized Carbon Column for Efficient Isomeric Separation of Permethylated Glycans

Author:
Gautam, Sakshi; Banazadeh, Alireza; Cho, Byeong Gwan; Goli, Mona; Zhong, Jieqiang; Mechref, Yehia
Source:
Analytical chemistry 2021 v.93 no.12 pp. 5061-5070
ISSN:
1520-6882
Subject:
glycoproteins,   etc   ; analytical chemistry; carbon; glycosylation; liquid chromatography; polysaccharides; porous media;     Show all 7 Subjects
Abstract:
... Post-translational modifications are vital aspects of functional proteins. Therefore, it is critical to understand their roles in biological processes. Glycosylation is particularly challenging to study among these modifications due to the heterogeneity displayed by the glycans in terms of their isomers. Thus, researchers continue to strive for the development of efficient liquid chromatography te ...
DOI:
10.1021/acs.analchem.0c04395

4. Dimerization of ER-resident molecular chaperones mediated by ERp29

Author:
Nakao, Hitomi; Seko, Akira; Ito, Yukishige; Sakono, Masafumi
Source:
Biochemical and biophysical research communications 2021 v.536 pp. 52-58
ISSN:
0006-291X
Subject:
glycoproteins,   etc   ; calnexin; calreticulin; dimerization; endoplasmic reticulum; quality control; research;     Show all 7 Subjects
Abstract:
... The lectin chaperones calnexin (CNX) and calreticulin (CRT) localized in the endoplasmic reticulum play important roles in glycoprotein quality control. Although the interaction between these lectin chaperones and ERp57 is well known, it has been recently reported that endoplasmic reticulum protein 29 (ERp29), a member of PDI family, interacts with CNX and CRT. The biochemical function of ERp29 is ...
DOI:
10.1016/j.bbrc.2020.12.023

5. An evolutionarily conserved charged residue dictates the specificity of heterophilic interactions among nectins

Author:
Duraivelan, Kheerthana; Dash, Sagarika; Samanta, Dibyendu
Source:
Biochemical and biophysical research communications 2021 v.534 pp. 504-510
ISSN:
0006-291X
Subject:
glycoproteins,   etc   ; cell adhesion; computer simulation; immunoglobulins; morphogenesis; research;     Show all 6 Subjects
Abstract:
... Nectins are a family of four cell surface glycoproteins belonging to the immunoglobulin superfamily that mediate cell-cell adhesion and associated signalling pathways, thereby regulating several physiological processes including morphogenesis, growth and development of multicellular organisms. Nectins interact among themselves through their extracellular domains from the adjacent cells in both hom ...
DOI:
10.1016/j.bbrc.2020.11.052

6. The conserved arginine residue in all siglecs is essential for Siglec-7 binding to sialic acid

Author:
Yoshimura, Atsushi; Hatanaka, Rina; Tanaka, Hiroshi; Kitajima, Ken; Sato, Chihiro
Source:
Biochemical and biophysical research communications 2021 v.534 pp. 1069-1075
ISSN:
0006-291X
Subject:
glycoproteins,   etc   ; arginine; gangliosides; lectins; mutation; research; sialic acid;     Show all 7 Subjects
Abstract:
... Siglecs are sialic acid (Sia)-binding immunoglobulin-like lectins; the majority of Siglecs functions as transmembrane receptors on the immune cells via Sia residues. Recently, a new Sia binding site in Siglec-7, termed site 2, where arginine (R) 67 was critical, was identified by computational modeling and biochemical analyses, relative to the primary Sia binding site, termed site 1, containing cr ...
DOI:
10.1016/j.bbrc.2020.10.023

7. An Ultrastructural Study of the Extruded Polar Tube of Anncaliia algerae (Microsporidia)

Author:
Takvorian, Peter M.; Han, Bing; Cali, Ann; Rice, William J.; Gunther, Leslie; Macaluso, Frank; Weiss, Louis M.
Source:
Thejournal of eukaryotic microbiology 2020 v.67 no.1 pp. 28-44
ISSN:
1066-5234
Subject:
glycoproteins,   etc   ; Microsporidia; microscopy; pathogenicity; spores;     Show all 5 Subjects
Abstract:
... All microsporidia share a unique, extracellular spore stage, containing the infective sporoplasm and the apparatus for initiating infection. The polar filament/polar tube when exiting the spore transports the sporoplasm through it into a host cell. While universal, these structures and processes have been enigmatic. This study utilized several types of microscopy, describing and extending our unde ...
DOI:
10.1111/jeu.12751
PubMed:
31332877
PubMed Central:
PMC6944765

8. P-glycoprotein (ABCB1) is involved in vitamin K efflux

Author:
Margier, Marielle; Le May, Cédric; Antoine, Tiffany; Halimi, Charlotte; Nowicki, Marion; Lespine, Anne; Reboul, Emmanuelle
Source:
Food chemistry 2021 v.343 pp. 128510
ISSN:
0308-8146
Subject:
P-glycoproteins,   etc   ; absorption; cholesterol; females; food chemistry; males; metabolism; mice; vitamin K;     Show all 9 Subjects
Abstract:
... ABCB1 (P-glycoprotein/MDR1) is a multidrug efflux transporter that has previously been involved in cholesterol and vitamin D metabolism. Our aim was to explore whether ABCB1 is also involved in vitamin K efflux. Vitamin K apical efflux was significantly decreased in presence of ABCB1 inhibitor in Caco-2 cells (−20.4%; p < 0.05) and increased in Griptite cells overexpressing ABCB1 (+40.7%; p < 0.05 ...
DOI:
10.1016/j.foodchem.2020.128510

9. Bioinformatic analysis and genetic engineering approaches for recombinant biopharmaceutical glycoproteins production in microalgae

Author:
Liu, Xiaojuan; Xie, Xihui; Du, Hong; Sanganyado, Edmond; Wang, Wanna; Aslam, Muhammad; Chen, Jichen; Chen, Weizhou; Liang, Honghao
Source:
Algal research 2021 v.55 pp. 102276
ISSN:
2211-9264
Subject:
glycoproteins,   etc   ; bioinformatics; biopharmaceuticals; genome; glycosidases; glycosylation; glycosyltransferases; humans; microalgae; phylogeny; research;     Show all 11 Subjects
Abstract:
... In recent years, interest in the use of microalgae as cell factories to produce biopharmaceutical glycoproteins increased observably. Microalgae often produce biopharmaceutical glycoproteins through post-translational modification of proteins via N-glycosylation. The biophysical properties of biopharmaceutical glycoproteins such as folding, stability, and molecular recognition are influenced by th ...
DOI:
10.1016/j.algal.2021.102276

10. Molecular analysis of cryptosporidiosis cases in Western Australia in 2019 and 2020 supports the occurrence of two swimming pool associated outbreaks and reveals the emergence of a rare C. hominis IbA12G3 subtype

Author:
Braima, Kamil; Zahedi, Alireza; Egan, Siobhon; Austen, Jill; Xiao, Lihua; Feng, Yaoyu; Witham, Benjamin; Pingault, Nevada; Perera, Shalinie; Oskam, Charlotte; Reid, Simon; Ryan, Una
Source:
Infection, genetics, and evolution 2021 pp. 104859
ISSN:
1567-1348
Subject:
glycoproteins,   etc   ; DNA; Protozoa; chlorine; cryptosporidiosis; evolution; gastroenteritis; genes; genetic variation; loci; microsatellite repeats; parasites; Western Australia;     Show all 13 Subjects
Abstract:
... Cryptosporidium is an important protozoan parasite and due to its resistance to chlorine is a major cause of swimming pool-associated gastroenteritis outbreaks. The present study combined contact tracing and molecular techniques to analyse cryptosporidiosis cases and outbreaks in Western Australia in 2019 and 2020. In the 2019 outbreak, subtyping at the 60 kDa glycoprotein (gp60) gene identified 8 ...
DOI:
10.1016/j.meegid.2021.104859

11. Investigation of gill mucus cells of Lake Van fish (Alburnus tarichi) during reproductive migration

Author:
Alkan, Zehra; Oğuz, Ahmet R.
Source:
Fish physiology and biochemistry 2021 v.47 no.2 pp. 409-419
ISSN:
0920-1742
Subject:
glycoproteins,   etc   ; Alburnus tarichi; anadromous fish; biodiversity; freshwater; histochemistry; lakes; mucus; pH; physiology; salinity;     Show all 11 Subjects
Abstract:
... Lake Van is the largest lake in Turkey. It is one of the few soda lakes in the world. Its water is brackish and soda. The lake water has a salinity rate of 19‰ and a pH of 9.8. The salty-soda content of the lake greatly limits biodiversity. Since the Lake Van fish is anadromous, it migrates from the extreme conditions of Lake Van to the freshwater pouring into the lake to spawn. In the same way, o ...
DOI:
10.1007/s10695-020-00921-6

12. P-glycoprotein induction and its energetic costs in rainbow trout (Oncorhynchus mykiss)

Author:
Kennedy, Christopher J.
Source:
Fish physiology and biochemistry 2021 v.47 no.2 pp. 265-279
ISSN:
0920-1742
Subject:
P-glycoproteins,   etc   ; Oncorhynchus mykiss; clotrimazole; dose response; energy; fish; hepatocytes; intraperitoneal injection; rhodamines; toxicity; xenobiotics;     Show all 11 Subjects
Abstract:
... Biological organisms are constantly challenged by xenobiotics and have evolved mechanisms to reduce, neutralize, or repair toxic outcomes. The various chemical defenses all utilize energy, but their specific costs and impacts on energy budgets are currently unknown. In this study, the energetic costs associated with the induction and substrate transport of the efflux transporter P-glycoprotein (P- ...
DOI:
10.1007/s10695-020-00911-8

13. Identification and semi-relative quantification of intact glycoforms of human chorionic gonadotropin alpha and beta subunits by nano liquid chromatography-Orbitrap mass spectrometry

Author:
Al Matari, Amira; Goumenou, Anastasia; Combès, Audrey; Fournier, Thierry; Pichon, Valérie; Delaunay, Nathalie
Source:
Journal of chromatography 2021 v.1640 pp. 461945
ISSN:
0021-9673
Subject:
glycoproteins,   etc   ; drugs; glycosylation; human chorionic gonadotropin; liquid chromatography; mass spectrometry; quality control;     Show all 7 Subjects
Abstract:
... The human chorionic gonadotropin (hCG) protein belongs to a family of glycoprotein hormones called gonadotropins. It is a heterodimer made of two non-covalently linked subunits. The α-subunit structure, hCGα, has 2 N-glycosylation sites, while the beta subunit, hCGβ, has 2 N- and 4 O-glycosylation sites. This leads to numerous glycoforms. A method based on the analysis of hCG glycoforms at the int ...
DOI:
10.1016/j.chroma.2021.461945

14. Sensitive and selective detection of glycoprotein based on dual-signal and dual-recognition electrochemical sensing platform

Author:
Chai, Rong; Wang, Yuanyuan; Kan, Xianwen
Source:
Food chemistry 2021 v.340 pp. 127944
ISSN:
0308-8146
Subject:
glycoproteins,   etc   ; boric acid; detection limit; electrochemistry; environment; ferrocenes; food chemistry; molecular imprinting; ovalbumin; polymers; sensors (equipment);     Show all 11 Subjects
Abstract:
... Glycoproteins play extraordinary roles in biology and clinic. The specifically sensitive detection of glycoproteins by electrochemical methods is still a challenging task due to their poor electro-activity and sensitive nature to environment. In this work, ovalbumin (OVA), a model glycoprotein, was sensitively detected by a molecularly imprinted polymer (MIP) based electrochemical sensor, which wa ...
DOI:
10.1016/j.foodchem.2020.127944

15. Structures of HCMV Trimer reveal the basis for receptor recognition and cell entry

Author:
Kschonsak, Marc; Rougé, Lionel; Arthur, Christopher P.; Hoangdung, Ho; Patel, Nidhi; Kim, Ingrid; Johnson, Matthew C.; Kraft, Edward; Rohou, Alexis L.; Gill, Avinash; Martinez-Martin, Nadia; Payandeh, Jian; Ciferri, Claudio
Source:
Cell 2021 v.184 no.5 pp. 1232-1244.e16
ISSN:
0092-8674
Subject:
glycoproteins,   etc   ; Human betaherpesvirus 5; electron microscopy; human population; neutralization; platelet-derived growth factor receptor alpha; therapeutics;     Show all 7 Subjects
Abstract:
... Human cytomegalovirus (HCMV) infects the majority of the human population and represents the leading viral cause of congenital birth defects. HCMV utilizes the glycoproteins gHgLgO (Trimer) to bind to platelet-derived growth factor receptor alpha (PDGFRα) and transforming growth factor beta receptor 3 (TGFβR3) to gain entry into multiple cell types. This complex is targeted by potent neutralizing ...
DOI:
10.1016/j.cell.2021.01.036

16. Expression analysis of chick Frizzled receptors during spinal cord development

Author:
Alrefaei, Abdulmajeed Fahad; Münsterberg, Andrea E.; Wheeler, Grant N.
Source:
Gene expression patterns 2021 v.39 pp. 119167
ISSN:
1567-133X
Subject:
glycoproteins,   etc   ; Drosophila; chicks; electroporation; gene expression; genes; hybridization; neurogenesis; spinal cord; synaptogenesis;     Show all 10 Subjects
Abstract:
... Frizzleds (Fzds) are transmembrane receptors that can transduce signals dependent upon binding of Wnts, a large family of secreted glycoproteins homologous to the Drosophila wingless gene. FZDs are critical for a wide variety of normal and pathological developmental processes. In the nervous system, Wnts and Frizzleds play an important role in anterior-posterior patterning, cell fate decisions, pr ...
DOI:
10.1016/j.gep.2021.119167

17. ABCB1 polymorphism in clopidogrel-treated Montenegrin patients

Author:
Mugosa, Snezana; Todorovic, Zoran; Cukic, Jelena; Sahman-Zaimovic, Majda; Djordjevic, Natasa
Source:
Open life sciences 2021 v.16 no.1 pp. 142-149
ISSN:
2391-5412
Subject:
P-glycoproteins,   etc   ; bioavailability; drugs; frequency distribution; genotyping; quantitative polymerase chain reaction; sample size;     Show all 7 Subjects
Abstract:
... Clopidogrel is an antiplatelet drug that displays significant interindividual variability in treatment response. Its bioavailability depends on the function of P-glycoprotein (P-gp), which is coded by a highly polymorphic ABCB1 gene. Thus, the aim of this study was to investigate the effect of ABCB1 genetic polymorphism on clopidogrel efficacy and safety and to determine the frequency distribution ...
DOI:
10.1515/biol-2021-0017

18. Edible Bird’s Nest: Physicochemical Properties, Production, and Application of Bioactive Extracts and Glycopeptides

Author:
Daud, Nur‘Aliah; Mohamad Yusop, Salma; Babji, Abdul Salam; Lim, Seng Joe; Sarbini, Shahrul Razid; Hui Yan, Tan
Source:
Food reviews international 2021 v.37 no.2 pp. 177-196
ISSN:
1525-6103
Subject:
glycoproteins,   etc   ; beverages; bioavailability; dietary supplements; glycopeptides; health foods; hydrolysis; nutrient content;     Show all 8 Subjects
Abstract:
... Edible bird’s nest (EBN), the swiftlet’s nest, has been consumed for centuries as a tonic or health food. The information upon the usage and benefits of the EBN are largely based on historical and observational reports since its discovery, until some were proven scientifically at recent times. Studies have been conducted on the major components of the EBN, i.e. glycoprotein, in attempts to elucida ...
DOI:
10.1080/87559129.2019.1696359

19. Chemical and enzymatic synthesis of S-linked sugars and glycoconjugates

Author:
Qiao, Meng; Zhang, Lihui; Jiao, Ruoyu; Zhang, Shilin; Li, Bingzhi; Zhang, Xing
Source:
Tetrahedron 2021 v.81 pp. 131920
ISSN:
0040-4020
Subject:
glycoproteins,   etc   ; affinity chromatography; antibiotics; antineoplastic agents; bioactive properties; glycolipids; ligands; oligosaccharides; oxygen; polysaccharides; saponins; sulfur; synthesis;     Show all 13 Subjects
Abstract:
... S-Linked oligosaccharide/polysaccharide and glycoconjugates including glycolipid, glycoprotein, saponin and others, in which the glycosidic oxygen is replaced by a sulfur atom, have attracted considerable attention as probes in biological investigations, due to the higher metabolic stability compared to their natural saccharide counterparts. Furthermore, these resulting S-linked glycosides maintai ...
DOI:
10.1016/j.tet.2020.131920

20. Quantitation of Cell Membrane Permeability of Cyclic Peptides by Single-Cell Cytoplasm Mass Spectrometry

Author:
Kawai, Takayuki; Mihara, Yasuhiro; Morita, Makiko; Ohkubo, Masahiko; Asami, Taiji; Watanabe, Tomonobu M.
Source:
Analytical chemistry 2021 v.93 no.7 pp. 3370-3377
ISSN:
1520-6882
Subject:
P-glycoproteins,   etc   ; analytical chemistry; cyclosporine; cytoplasm; drug development; mass spectrometry; membrane permeability;     Show all 7 Subjects
Abstract:
... Cyclic peptides (CPs) have attracted attention as next-generation drugs because they possess both cell-permeable potential as small molecules and specific affinity similar to antibodies. As intracellular molecules are important targets of CPs, quantitation of the intracellular retention and transmembrane permeability of CPs is necessary for drug development. However, permeated CPs within cells can ...
DOI:
10.1021/acs.analchem.0c03901