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You searched for: Subject "glycosylation" Remove constraint Subject: "glycosylation"
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1. Conjugated type A trichothecenes in oat-based products: Occurrence data and estimation of the related risk

Author:
Nela Prusova; Adam Behner; Zbynek Dzuman; Jana Hajslova; Milena Stranska
Source:
Food control 2023 v.143 pp. 109281
ISSN:
0956-7135
Subject:
glycosylation,   etc   ; HT-2 toxin; T-2 toxin; bioavailability; enzymatic hydrolysis; food safety; glycosides; mass spectrometry; risk; risk assessment; ultra-performance liquid chromatography;     Show all 11 Subjects
Abstract:
... Currently, increasing attention is being paid to conjugated mycotoxins in plant-based foods because of their assumed bioavailability and health risks. However, analytical standards for most mycotoxin glycosides are not available and risk assessment processes have not yet been completed because of the lack of occurrence data. Our study presents a method for efficient pre-concentration of type A tri ...
DOI:
10.1016/j.foodcont.2022.109281

2. Glycosylated peptide-calcium chelate: Characterization, calcium absorption promotion and prebiotic effect

Author:
Xiaoping Wu; Fangfang Wang; Xixi Cai; Shaoyun Wang
Source:
Food chemistry 2023 v.403 pp. 134335
ISSN:
0308-8146
Subject:
glycosylation,   etc   ; Maillard reaction; absorption; amino nitrogen; bioavailability; calcium; calcium deficiency; calcium phosphates; colonizing ability; crystallization; fermentation; food chemistry; gastrointestinal system; human cell lines; intestinal microorganisms; oxygen; prebiotics; xylooligosaccharides;     Show all 18 Subjects
Abstract:
... Finding functional preparations that could improve the bioavailability of calcium is one of the keys to solving calcium deficiency. In this study, glycosylated peptides-calcium chelate with calcium absorption promoting activity, named XOS-CSPHs-Ca-MR, was prepared from Crimson Sapper scales protein hydrolysates (CSPHs) and xylooligosaccharides (XOS) via Maillard reaction. Results showed that amino ...
DOI:
10.1016/j.foodchem.2022.134335

3. Molecular characterization, expression patterns, and subcellular localization of a classical and a novel nonclassical MHC class I α molecules from Japanese eel Anguilla japonica

Author:
Jianjun Feng; Xinwei Peng; Peng Lin; Yilei Wang; Ziping Zhang; Yuankai Xu; Pengyun Chen; Jingying Wu
Source:
Aquaculture and fisheries 2023 v.8 no.2 pp. 108-123
ISSN:
2468-550X
Subject:
glycosylation,   etc   ; Aeromonas hydrophila; Anguilla japonica; amino acid sequences; aquaculture; bacterial infections; cytoplasm; fish; humans; immune response; intestines; kidneys; liver; major histocompatibility complex; phylogeny; polyinosinic-polycytidylic acid; quantitative polymerase chain reaction; spleen;     Show all 18 Subjects
Abstract:
... Major histocompatibility complex (MHC) molecules play a critical role in the immune response of vertebrate animals by presenting foreign antigens to T lymphocytes. In this study, we first cloned and identified a classical and a novel nonclassical MHC I α molecules from Japanese eel (Anguilla japonica), named as AjMHC I-UBA and AjMHC I-L, respectively. The full-length cDNA of AjMHC I-UBA contains a ...
DOI:
10.1016/j.aaf.2021.08.005

4. Improving the viability of Lactobacillus plantarum LP90 by carboxymethylated dextran-whey protein conjugates: The relationship with glass transition temperature

Author:
Wen Li; Yunjiao Zhao; Yuan Zhao; Shunqin Li; Liyuan Yun; Zijian Zhi; Rui Liu; Tao Wu; Wenjie Sui; Min Zhang
Source:
Food hydrocolloids 2023 v.134 pp. 108102
ISSN:
0268-005X
Subject:
glycosylation,   etc   ; Lactobacillus plantarum; Maillard reaction; dextran; digestion; fluorescence emission spectroscopy; freeze drying; gastric juice; gastrointestinal system; glass transition temperature; hydrocolloids; infrared spectroscopy; microencapsulation; polyacrylamide gel electrophoresis; probiotics; storage quality; survival rate; viability; whey protein;     Show all 19 Subjects
Abstract:
... Microcapsules can provide better protection for probiotics during freeze-drying and gastrointestinal digestion. This study aims to investigate the effect of microencapsulation using the product of the Maillard reaction of whey protein and carboxymethylated dextran (CM. dex) on the viability of Lactobacillus plantarum LP90 (Lₚ) as related to freeze-drying, gastrointestinal tolerability and storage ...
DOI:
10.1016/j.foodhyd.2022.108102

5. Synthesis and Glycosidation of Anomeric Halides: Evolution from Early Studies to Modern Methods of the 21st Century

Author:
Yashapal Singh; Scott A. Geringer; Alexei V. Demchenko
Source:
Chemical reviews 2022 v.122 no.13 pp. 11701-11758
ISSN:
1520-6890
Subject:
glycosylation,   etc   ; evolution; polysaccharides;     Show all 3 Subjects
Abstract:
... Advances in synthetic carbohydrate chemistry have dramatically improved access to common glycans. However, many novel methods still fail to adequately address challenges associated with chemical glycosylation and glycan synthesis. Since a challenge of glycosylation has remained, scientists have been frequently returning to the traditional glycosyl donors. This review is dedicated to glycosyl halid ...
DOI:
10.1021/acs.chemrev.2c00029

6. Stereoselective gem-C,B-Glycosylation via 1,2-Boronate Migration

Author:
Wei-Cheng Zhao; Rui-Peng Li; Chao Ma; Qi-Ying Liao; Miao Wang; Zhi-Tao He
Source:
Journal of the American Chemical Society 2022 v.144 no.6 pp. 2460-2467
ISSN:
1520-5126
Subject:
glycosylation,   etc   ; alkenes; stereoselectivity;     Show all 3 Subjects
Abstract:
... A novel protocol is established for the long-standing challenge of stereoselective geminal bisglycosylations of saccharides. The merger of PPh₃ as a traceless glycosidic leaving group and 1,2-boronate migration enables the simultaneous introduction of C–C and C–B bonds at the anomeric stereogenic center of furanoses and pyranoses. The power of this method is showcased by a set of site-selective mo ...
DOI:
10.1021/jacs.1c11842

7. Insights into the Activation of Alkyne-Installed Glycosyl Donors with Dual Acidic Metal Catalysts: Reaction Pathway, Influencing Factors, and Enlightenment for Glycosylation

Author:
Chenglin Cai; Xingchun Sun; Yingle Feng; Qi Zhang; Yonghai Chai
Source:
Organic letters 2022 v.24 no.34 pp. 6266-6271
ISSN:
1523-7052
Subject:
glycosylation,   etc   ; catalysts; sugars;     Show all 3 Subjects
Abstract:
... The activation of alkyne-installed glycosyl donors with dual acidic metal catalysts were studied. Lewis and/or π acidity-activated pathways were observed for alkynyl carbonate-, ester-, and ether-type donors, and π acidity-promoted reaction mode afforded higher efficiency and yields. The activation mode for a certain metal catalyst is determined by the nature of catalysts itself, protecting groups ...
DOI:
10.1021/acs.orglett.2c02338

8. Broadening the Scope of the Reverse Orthogonal Strategy for Oligosaccharide Synthesis

Author:
Scott A. Geringer; Gustavo A. Kashiwagi; Alexei V. Demchenko
Source:
Journal of organic chemistry 2022 v.87 no.15 pp. 9887-9895
ISSN:
1520-6904
Subject:
glycosylation,   etc   ; oligosaccharides; organic chemistry;     Show all 3 Subjects
Abstract:
... The reverse orthogonal strategy was invented in 2011 in an attempt to address drawbacks of other strategies for glycan assembly. Different from the classical orthogonal approach that relies on the orthogonality of leaving groups, the reverse strategy is based on orthogonal protecting groups that could be removed during the glycosylation step. This strategy remained largely unexplored due to only o ...
DOI:
10.1021/acs.joc.2c00905

9. GeCl₂·Dioxane–AgBF₄ Catalyzed Activation of Glycosyl Fluorides for Glycosylation

Author:
Qiuyu Zhu; Yu Tang; Biao Yu
Source:
Organic letters 2022 v.24 no.20 pp. 3626-3630
ISSN:
1523-7052
Subject:
glycosylation,   etc   ; ambient temperature; cations;     Show all 3 Subjects
Abstract:
... A catalytic glycosyl fluoride activation system using the GeCl₂·dioxane–AgBF₄ combination was developed, which involves a reversible activation of the anomeric C–F bond by a [Ge(II)–Cl]⁺ cation and a reversible chloride ion transfer between Ge(II) and glycosyl cations. This catalytic glycosylation system is easy to operate, proceeds at room temperature, and offers a broad scope of substrates. ...
DOI:
10.1021/acs.orglett.2c01146

10. Mucopedia 101: capturing and assigning mucin-domain glycoproteins

Author:
Abigail E. Reeves; Mia L. Huang
Source:
Trends in microbiology 2022 pp. -
ISSN:
0966-842X
Subject:
glycosylation,   etc   ; microbiology; mucins; prediction;     Show all 4 Subjects
Abstract:
... Glycoproteins bearing mucin domains serve important biological functions, yet they are understudied due to their dense glycosylation. Malaker et al. describe a new tool that will advance the capture, identification, and prediction of new members of the ‘mucinome’. ...
DOI:
10.1016/j.tim.2022.09.004

11. Total Synthesis of an All-1,2-cis-Linked Repeating Unit from the Acinetobacter baumannii D78 Capsular Polysaccharide

Author:
Dancan K. Njeri; Justin R. Ragains
Source:
Organic letters 2022 v.24 no.19 pp. 3461-3465
ISSN:
1523-7052
Subject:
glycosylation,   etc   ; Acinetobacter baumannii; polysaccharides;     Show all 3 Subjects
Abstract:
... Chemical synthetic efforts have resulted in the preparation of the assigned tetrasaccharide repeating subunit from the Acinetobacter baumannii KL4-associated capsular polysaccharide. A convergent synthetic strategy hinging on a 1,2-cis-selective [2+2] glycosylation to generate the fully protected tetrasaccharide was key to the success of this synthesis. ...
DOI:
10.1021/acs.orglett.2c01034

12. General Strategy for the Synthesis of Rare Sugars via Ru(II)-Catalyzed and Boron-Mediated Selective Epimerization of 1,2-trans-Diols to 1,2-cis-Diols

Author:
Xiaolei Li; Jicheng Wu; Weiping Tang
Source:
Journal of the American Chemical Society 2022 v.144 no.8 pp. 3727-3736
ISSN:
1520-5126
Subject:
glycosylation,   etc   ; glycoconjugates; glycosides; humans; polysaccharides;     Show all 5 Subjects
Abstract:
... Human glycans are primarily composed of nine common sugar building blocks. On the other hand, several hundred monosaccharides have been discovered in bacteria and most of them are not readily available. The ability to access these rare sugars and the corresponding glycoconjugates can facilitate the studies of various fundamentally important biological processes in bacteria, including interactions ...
DOI:
10.1021/jacs.1c13399

13. One-pot expeditious synthesis of glycosylated esters through activation of carboxylic acids using trichloroacetonitrile

Author:
Mangal S. Yadav; Manoj K. Jaiswal; Sunil Kumar; Sumit K. Singh; Faisal J. Ansari; Vinod K. Tiwari
Source:
Carbohydrate research 2022 v.521 pp. 108674
ISSN:
0008-6215
Subject:
glycosylation,   etc   ; carboxylic acids; research; sugars;     Show all 4 Subjects
Abstract:
... Acetimidates, a valuable intermediate has been well explored as versatile synthon in a number of organic transformations particularly as suitable donors in glycosylation reactions. Herein, we explored acetimidates to furnish high-to-excellent yield of diverse glycosylated esters under one-pot mild reaction condition. The commercially available trichloroacetonitrile is implemented for the activatio ...
DOI:
10.1016/j.carres.2022.108674

14. Balancing O‐GlcNAc and O‐fucose in plants

Author:
Krishna Vasant Mutanwad; Doris Lucyshyn
Source:
FEBS journal 2022 v.289 no.11 pp. 3086-3092
ISSN:
1742-464X
Subject:
glycosylation,   etc   ; animals; eukaryotic cells; glycosidases;     Show all 4 Subjects
Abstract:
... O‐linked modification of nuclear and cytosolic proteins with monosaccharides is essential in all eukaryotes. While many aspects of this post‐translational modification are highly conserved, there are striking differences between plants and the animal kingdom. In animals, dynamic cycling of O‐GlcNAc is established by two essential single copy enzymes, the O‐GlcNAc transferase OGT and O‐GlcNAc hydro ...
DOI:
10.1111/febs.16038

15. Enzymatic transglycosylation by the Ping Pong bi bi mechanism: Selectivity for transglycosylation versus primary and secondary hydrolysis

Author:
Josiane Proença Fagundes; Fernando Augusto Pedersen Voll; Nadia Krieger; David Alexander Mitchell
Source:
Biochemical engineering journal 2022 v.182 pp. 108440
ISSN:
1369-703X
Subject:
glycosylation,   etc   ; enzymes; hydrolysis; models; oligosaccharides;     Show all 5 Subjects
Abstract:
... There has been a recent surge of interest in producing oligosaccharides by transglycosylation. In enzyme-catalyzed transglycosylations that follow the Ping Pong bi bi mechanism, there are three competing reactions: the transglycosylation itself, primary hydrolysis (i.e. of the initial donor molecule) and secondary hydrolysis (i.e. of the transglycosylation product). In kinetically controlled trans ...
DOI:
10.1016/j.bej.2022.108440

16. Identification of side-reaction products generated during the ammonia-catalyzed release of N-glycans

Author:
Chia Yen Liew; Jien-Lian Chen; Shang-Ting Tsai; Chi-Kung Ni
Source:
Carbohydrate research 2022 v.522 pp. 108686
ISSN:
0008-6215
Subject:
glycosylation,   etc   ; N-acetylglucosamine; isomers; research;     Show all 4 Subjects
Abstract:
... N-linked glycosylation is one of the most important post translational modification of proteins. Various analytical techniques are used for the structural identification of the N-glycans released from proteins through various enzymatic and chemical methods. Although very few side-reaction products are generated during the enzymatic release of N-glycans, this method is expensive and suitable only f ...
DOI:
10.1016/j.carres.2022.108686

17. Lfng and Dll3 cooperate to modulate protein interactions in cis and coordinate oscillatory Notch pathway activation in the segmentation clock

Author:
Matthew S. Bochter; Dustin Servello; Shinako Kakuda; Rachel D'Amico; Meaghan F. Ebetino; Robert S. Haltiwanger; Susan E. Cole
Source:
Developmental biology 2022 v.487 pp. 42-56
ISSN:
0012-1606
Subject:
glycosylation,   etc   ; epistasis; ligands; mammals; mesoderm; mutants;     Show all 6 Subjects
Abstract:
... In mammalian development, oscillatory activation of Notch signaling is required for segmentation clock function during somitogenesis. Notch activity oscillations are synchronized between neighboring cells in the presomitic mesoderm (PSM) and have a period that matches the rate of somite formation. Normal clock function requires cyclic expression of the Lunatic fringe (LFNG) glycosyltransferase, as ...
DOI:
10.1016/j.ydbio.2022.04.004

18. Scalable total synthesis of natural vanillin-derived glucoside ω-esters

Author:
David L. Avetyan; Andrey Shatskiy; Markus D. Kärkäs; Elena V. Stepanova
Source:
Carbohydrate research 2022 v.522 pp. 108683
ISSN:
0008-6215
Subject:
glycosylation,   etc   ; derivatization; glucosides; research; toxicity; vanillin;     Show all 6 Subjects
Abstract:
... The first total synthesis of vanilloloside, calleryanin, and a series of naturally occurring ω-esters of vanilloloside was realized through direct glycosylation of vanillin-based aglycones or late-stage derivatization of vanilloloside. All aglycones and their fragments were synthesized from vanillin as the sole aromatic precursor. Subsequently, these intermediates were used to construct various va ...
DOI:
10.1016/j.carres.2022.108683

19. Comprehensive site- and structure-specific characterization of N-glycosylation in model plant Arabidopsis using mass-spectrometry-based N-glycoproteomics

Author:
Shanshan Qin; Suideng Qin; Zhixin Tian
Source:
Journal of chromatography 2022 v.1198 pp. 123234
ISSN:
1570-0232
Subject:
glycosylation,   etc   ; Arabidopsis; bioprocessing; databases; glycoproteins; glycoproteomics;     Show all 6 Subjects
Abstract:
... The N-glycosylation is an important bioprocess in plant. Monosaccharide composition-level characterization at the intact N-glycopeptides has been extensively reported, yet structure-specific study to resolve multiple sequence structures of a single composition is still lacking. Here, we present a comprehensive structure-specific identification of intact N-glycopeptides of Arabidopsis with both HIL ...
DOI:
10.1016/j.jchromb.2022.123234

20. Synthesis and Azobenzene Isomerization Investigation of Photoswitchable Glycomacrocycles

Author:
Jinbiao Jiao; Stéphane Maisonneuve; Juan Xie
Source:
Journal of organic chemistry 2022 v.87 no.13 pp. 8534-8543
ISSN:
1520-6904
Subject:
glycosylation,   etc   ; acidity; organic chemistry; photoisomerization; stereoselectivity;     Show all 5 Subjects
Abstract:
... Macrocyclic glycoazobenzenes, as an emerging class of photoswitchable chiral macrocyclic compounds, have shown interesting properties since their discovery in 2017. We have recently employed the azobenzene-ester-linked glycosyl donor–acceptor pairs to study the influence of photoisomerization on intramolecular glycosylation. To continue the investigation on the stereoselectivity aspect of glycosyl ...
DOI:
10.1021/acs.joc.2c00652