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1. Circ_0000591 served as endogenous RNA for miR-326 to promote progression of cholangiocarcinoma via the TLR4/MyD88/IL6 axis

Author:
Fenqiang Xiao; Fei Xu; Hua Zhang; Xiaoming Shuai
Source:
Biochemical and biophysical research communications 2022 v.600 pp. 101-108
ISSN:
0006-291X
Subject:
hepatoma,   etc   ; carcinogenesis; liver; prognosis; research;     Show all 5 Subjects
Abstract:
... Cholangiocarcinoma (CCA) is the second most common liver malignancy with poor prognosis after hepatocellular carcinoma (HCC). Emerging evidences have proved that circular RNAs (circRNAs) are involved in the progression of multiple cancers, while their roles in tumorigenesis of CCA remains largely unclear. In the present study, we found circ_0000591 was upregulated in CCA cells and tissues. The hig ...
DOI:
10.1016/j.bbrc.2022.02.073

2. Evaluation of staging systems to predict prognosis in hepatocellular carcinoma patients treated with radioembolization

Author:
Ece Meram; Colin Longhurst; Baran Umut Vardar; Kerim Karaoglu; Paul F. Laeseke; Orhan S. Ozkan
Source:
Heliyon 2022 v.8 no.1 pp. e08770
ISSN:
2405-8440
Subject:
hepatoma,   etc   ; models; patients; prognosis; regression analysis; China;     Show all 6 Subjects
Abstract:
... To compare the prognostic accuracy of nine staging systems, some of which are well-known and some of which have only been more recently described, for patients with unresectable HCC treated with radioembolization (RE). Individual scores or classes for the following staging systems were recorded or calculated for patients (n = 89) with unresectable HCC who underwent RE at a single tertiary care cen ...
DOI:
10.1016/j.heliyon.2022.e08770

3. Dahuang Zhechong pills inhibit liver cancer growth in a mouse model by reversing Treg/Th1 balance

Author:
Tian-Tian CHEN; Sha-Li DU; Shi-Jun WANG; Li WU; Lu YIN
Source:
Chinese journal of natural medicines 2022 v.20 no.2 pp. 102-110
ISSN:
1875-5364
Subject:
hepatoma,   etc   ; carcinoma; hepatitis; immune response; mice; pharmacology; spleen;     Show all 7 Subjects
Abstract:
... The infiltration of immune cells into the hepatocellular carcinoma microenvironment is the main reason why hepatocellular carcinoma patients are prone to carcinoma recurrence and the disease are incurable. Notably, the infiltration of Treg cells is the main trigger. Dahuang Zhechong pill (DHZCP) is a traditional Chinese herbal compound successful in the treatment of hepatitis and hepatocellular ca ...
DOI:
10.1016/S1875-5364(22)60160-2

4. Screening Linear and Circular RNA Transcripts from Stress Granules

Author:
Shuai Chen; Jinyang Zhang; Fangqing Zhao
Source:
Genomics, proteomics & bioinformatics 2022 pp. -
ISSN:
1672-0229
Subject:
hepatoma,   etc   ; bioinformatics; circular RNA; genomics; humans; proteomics; ribonucleoproteins;     Show all 7 Subjects
Abstract:
... Stress granules (SGs) are cytoplasmic ribonucleoprotein assemblies formed under stress conditions and are related to various biological processes and human diseases. Previous studies have reported the regulatory role of some proteins and linear RNAs in SG assembly. However, the relationship between circular RNAs and SGs has not been discovered. Here, we screened both linear and circular RNAs in SG ...
DOI:
10.1016/j.gpb.2022.01.003

5. Synthesis and antitumor activity of benzophenone compound

Author:
Bei-Dou Zhou; Rong-Rong Wei; Jia-Li Li; Zi-Han Yu; Zhi-Min Weng; Zhi-Peng Ruan; Jian Lin; Yuan-Yuan Fang; Gui-Fen Xu; Dong-Bao Hu
Source:
Journal of Asian natural products research 2022 v.24 no.2 pp. 170-178
ISSN:
1477-2213
Subject:
hepatoma,   etc   ; antineoplastic activity; benzophenones; cisplatin; cytotoxicity; paclitaxel; research;     Show all 7 Subjects
Abstract:
... Seven benzophenone compounds were synthesized in one or two steps, then their antitumor activity was evaluated. The total yields ranged from 9% to 44%. Compounds 3c–5c exhibited obvious antitumor activity. Among them, compounds 3c and 4c exhibited excellent and broad-spectrum antitumor activity. Compound 3c exhibited much stronger inhibitory activities against fourteen cancer cells than cisplatin. ...
DOI:
10.1080/10286020.2021.1886090

6. Covalent Biosensing Polymer Chain Reaction Enabling Periphery Blood Testing to Predict Tumor Invasiveness with a Platelet Procancerous Protein

Author:
Yaxin Zhang; Yunyan Zhang; Hao Li; Yi Cao; Shiyuan Han; Kai Zhang; Wenxing He
Source:
Analytical chemistry 2022 v.94 no.4 pp. 1983-1989
ISSN:
1520-6882
Subject:
hepatoma,   etc   ; analytical chemistry; catalytic activity; electrochemistry; enzyme activity; polymers;     Show all 6 Subjects
Abstract:
... Periphery blood testing is an attractive and relatively less invasive way of early cancer screening. In this work, based on the latest understanding of the pivotal role of platelets in promoting cancer invasion, a method for detecting a procancerous protein overexpressed both on platelets and in cancer cells is developed. As a kinase, the enzymatic activity, abundance, and self-phosphorylation of ...
DOI:
10.1021/acs.analchem.1c03349

7. Development of oral curcumin based on pH-responsive transmembrane peptide-cyclodextrin derivative nanoparticles for hepatoma

Author:
Tiantian Wei; Yin Zhang; Meng Lei; Yanru Qin; Zhongjie Wang; Zhimeng Chen; Liefeng Zhang; Yongqiang Zhu
Source:
Carbohydrate polymers 2022 v.277 pp. 118892
ISSN:
0144-8617
Subject:
hepatoma,   etc   ; apoptosis; curcumin; cyclodextrins; endocytosis; histology; lysosomes; pH; reticulin;     Show all 9 Subjects
Abstract:
... Herein, a pH-responsive cyclodextrin derivative (R6H4-CMβCD) with cell-penetrating ability was successfully synthesized, and curcumin-loaded nanoparticles (R6H4-CMβCD@CUR NPs, RCCNPs) were developed to improve its efficacy in hepatoma. RCCNPs could improve the cell uptake compared with CMβCD@CUR NPs (CCNPs) and were internalized into cells mainly through endocytosis mediated by reticulin and macro ...
DOI:
10.1016/j.carbpol.2021.118892

8. A New Stilbenoid from Caryopteris incana

Author:
Dekun Chen; Kai Zhang; Jianbing Tan; Sha Zhang; Kangping Xu; Wenxuan Wang; Fenghua Kang; Zhenxing Zou; Guishan Tan
Source:
Chemistry of natural compounds 2022 v.58 no.2 pp. 199-202
ISSN:
0009-3130
Subject:
hepatoma,   etc   ; Caryopteris incana; apigenin; caffeic acid; chemistry; cytotoxicity; humans; luteolin; quercetin;     Show all 9 Subjects
Abstract:
... A new stilbenoid, methyl 2,4-dihydroxy-6-(4-hydroxyphenethyl)-3-methylbenzoate (1), along with 11 known compounds, cirsimaritin (2), cirsiliol (3), quercetin (4), apigenin (5), acacetin (6), genkwanin (7), luteolin (8), caffeic acid (9), esculetin (10), alternariol (11), and alternariol-5-O-methyl ether (12), was isolated from the 70% EtOH extract of Caryopteris incana. The structures of these com ...
DOI:
10.1007/s10600-022-03640-x

9. Personalized circulating tumor DNA in patients with hepatocellular carcinoma: a pilot study

Author:
H. C. Pommergaard; C. W. Yde; L. B. Ahlborn; C. L. Andersen; T. V. Henriksen; J. P. Hasselby; A. A. Rostved; C. L. Sørensen; K. S. Rohrberg; F. C. Nielsen; A. Rasmussen
Source:
Molecular biology reports 2022 v.49 no.2 pp. 1609-1616
ISSN:
0301-4851
Subject:
hepatoma,   etc   ; DNA; blood sampling; liver; molecular biology; mutational analysis; patients; resection;     Show all 8 Subjects
Abstract:
... BACKGROUND: Mutational analysis of circulating tumor DNA (ctDNA) can potentially be used for early detection of recurrence after resection for hepatocellular carcinoma (HCC). Mutations from tumor may be identified in plasma as an early sign of recurrence. We conducted a pilot study investigating if somatic mutations could be detected in plasma in patients undergoing liver resection for HCC and in ...
DOI:
10.1007/s11033-021-06962-1

10. Imaging and Detection of Hepatocellular Carcinoma with a Hepatocyte-Specific Fluorescent Probe

Author:
Zihong Li; Jie Cheng; Ping Huang; Wenhui Song; Li Nong; Ling Huang; Weiying Lin
Source:
Analytical chemistry 2022 v.94 no.7 pp. 3386-3393
ISSN:
1520-6882
Subject:
hepatoma,   etc   ; analytical chemistry; cellular microenvironment; death; fluorescence; fluorescent dyes; hepatocytes; liver; viscosity;     Show all 9 Subjects
Abstract:
... Hepatocellular carcinoma is a highly invasive malignant tumor of the liver, which is the main cause of cancer-related death. The cancerization of hepatocytes may lead to the changes of cell microenvironment, active substances, and enzymes. Viscosity is one of the important parameters of cell microenvironment. Therefore, the study of the change in the viscosity of hepatocytes is very important for ...
DOI:
10.1021/acs.analchem.1c05540

11. Jianpi Huayu decoction inhibits the epithelial–mesenchymal transition of hepatocellular carcinoma cells by suppressing exosomal miR-23a-3p/Smad signaling

Author:
Chun-Feng Xie; Kun-Liang Feng; Ji-Nan Wang; Rui Luo; Chong-Kai Fang; Ying Zhang; Chuang-Peng Shen; Chong Zhong
Source:
Journal of ethnopharmacology 2022 pp. 115360
ISSN:
0378-8741
Subject:
hepatoma,   etc   ; blood serum; cell proliferation; exosomes; hepatectomy; models; quality control; traditional medicine;     Show all 8 Subjects
Abstract:
... Jianpi Huayu decoction (JHD) is a traditional Chinese medicinal preparation used to treat a variety of malignant tumors including HCC, although the underlying mechanism remains unknown. Exosomes in the tumor microenvironment mediate intercellular signaling among cancer cells, but precise contributions to hepatocellular carcinoma (HCC) progression are still elusive. In this work, the main objective ...
DOI:
10.1016/j.jep.2022.115360

12. Two new polycyclic polyprenylated acylphloroglucinols from Hypericum curvisepalum N. Robson

Author:
Zhong-Bo Zhou; Wen-Pan Shi; Hong Zeng; You-Yi Huang; Xian Wei; Ke Pan; Li-Ping Teng
Source:
Phytochemistry letters 2022 v.48 pp. 43-46
ISSN:
1874-3900
Subject:
hepatoma,   etc   ; Bacillus subtilis; Hypericum; circular dichroism spectroscopy; cytotoxicity; humans; phytochemicals; spectral analysis;     Show all 8 Subjects
Abstract:
... Phytochemical investigation of the whole plant of Hypericum curvisepalum led to the isolation of nine polycyclic polyprenylated acylphloroglucinols (1–9). Among them, curvisepalumiones A (1) and B (2) are two new compounds and their structures were elucidated based on extensive spectroscopic data analysis combined with Rh₂(OCOCF₃)₄-induced electronic circular dichroism experiment. Cytotoxic assay ...
DOI:
10.1016/j.phytol.2022.01.015

13. Berberisides A-D: three novel prenylated benzoic acid derivatives and a clerodane glycoside from Berberis tsarica aherndt.

Author:
Zhao-Yue Dong; Qing-Hong Zeng; Lin Wei; Xin Guo; Yan Sun; Fan-Cheng Meng; Guo-Wei Wang; Xiao-Zhong Lan; Zhi-Hua Liao; Min Chen
Source:
Natural product research 2022 v.36 no.8 pp. 1996-2001
ISSN:
1478-6427
Subject:
hepatoma,   etc   ; Berberis; benzoic acid; breast neoplasms; cytotoxicity; glycosides; lung neoplasms; neoplasm cells; research;     Show all 9 Subjects
Abstract:
... Three undescribed prenylated benzoic acid derivatives berberisides A-C (1-3) and a new clerodane glycoside berberiside D (4) were isolated from Berberis tsarica Aherndt. Their structures were elucidated on the basis of extensive NMR and HR-ESI-MS analysis. The in vitro cytotoxic activities of all isolates were studied against lung carcinoma A549, hepatocellular carcinoma HepG2 and breast carcinoma ...
DOI:
10.1080/14786419.2020.1839460

14. Prolonged blood circulation outperforms active targeting for nanocarriers-mediated enhanced hepatocellular carcinoma therapy in vivo

Author:
Yue-Qing Wang; Cong Huang; Peng-Ju Ye; Jin-Rong Long; Cheng-Hu Xu; Ying Liu; Xiao-Li Ling; Shao-Yang Lv; Dong-Xiu He; Hua Wei; Cui-Yun Yu
Source:
Journal of controlled release 2022 v.347 pp. 400-413
ISSN:
0168-3659
Subject:
hepatoma,   etc   ; biomimetics; biosafety; blood; blood circulation; chemical bonding; dialysis; drugs; ligands; macrophages; nanocarriers;     Show all 11 Subjects
Abstract:
... Successful hepatocellular carcinoma (HCC) therapy in vivo remains a significant challenge due to the down-regulated expression of the receptors on the surface of tumor cells for compromised active targeting efficiency and cellular uptake of nanoparticles (NPs)-based drug delivery systems (DDSs) and “accelerated blood clearance” and premature unpackaging of NPs in vivo induced by the poly(ethylene ...
DOI:
10.1016/j.jconrel.2022.05.024

15. The nature compound dehydrocrenatidine exerts potent antihepatocellular carcinoma by destroying mitochondrial complexes in vitro and in vivo

Author:
Zi‐Lin Hou; Feng‐Ying Han; Li‐Li Lou; Wen‐Yu Zhao; Xiao‐Xiao Huang; Guo‐Dong Yao; Shao‐Jiang Song
Source:
Phytotherapy research 2022 v.36 no.3 pp. 1353-1371
ISSN:
0951-418X
Subject:
hepatoma,   etc   ; Picrasma quassioides; alkaloids; apoptosis; carcinoma; mitochondria; oxidative phosphorylation; phytotherapy; research; synergism; toxicity;     Show all 11 Subjects
Abstract:
... Cumulative evidence indicates that mitochondria dysfunction plays an important role in tumour treatment. Given the limited efficacy and toxicity of current mitochondria‐targeted drugs, research into effective mitochondria‐targeted anticancer agents remains an irresistible general trend. In this study, it was found that dehydrocrenatidine (DEC), a β‐carbolin alkaloid isolated from Picrasma quassiod ...
DOI:
10.1002/ptr.7398

16. Crosstalk of LncRNA HOTAIR and SP1-mediated repression of PDK1 contributes to β-Elemene-inhibited proliferation of hepatocellular carcinoma cells

Author:
JingJing Wu; XiaoJuan Tang; Yao Shi; ChangJu Ma; Hongyu Zhang; Junhong Zhang; Yue Lu; Jianan Wei; Li Li; Ling Han
Source:
Journal of ethnopharmacology 2022 v.283 pp. 114456
ISSN:
0378-8741
Subject:
hepatoma,   etc   ; Curcuma; cell growth; cell proliferation; flow cytometry; liver; plasmids; prognosis; traditional medicine; transfection;     Show all 10 Subjects
Abstract:
... Hepatocellular carcinoma (HCC) is a liver malignancy which lacks effective treatment and has a poor prognosis. β-Elemene refers to a natural Curcuma wenyujin-derived single molecular entity, which exhibits various biological activities, and is especially well-known for it's antitumor properties.LncRNA HOTAIR, SP1, and PDK1 have displayed oncogenic roles in many tumors, participating in the initiat ...
DOI:
10.1016/j.jep.2021.114456

17. Cytotoxic and anti-tumor effects of 3,4-seco-lupane triterpenoids from the leaves of Eleutherococcus sessiliflorus against hepatocellular carcinoma

Author:
Haohao Wang; Wenliu Yu; Danfeng Zhang; Yan Zhao; Chen Chen; Hongyan Zhu; Enbo Cai; Zhaowei Yan
Source:
Natural product research 2022 v.36 no.4 pp. 1062-1066
ISSN:
1478-6427
Subject:
hepatoma,   etc   ; Eleutherococcus sessiliflorus; Western blotting; apoptosis; cytotoxicity; ethanol; fluorescence; human cell lines; research; triterpenoids;     Show all 10 Subjects
Abstract:
... A rich of 3,4-seco-lupane triterpenoids (3,4-SLT), including chiisanoside (CSS), divaroside (DVS), sessiloside-A1 (SSA), chiisanogenin (CSG), sessiligenin (SSG), were isolated from the ethanol extract of the leaves of Eleutherococcus sessiliflorus (LES). The present study was performed to explore the cytotoxic and anti-tumor effects of the isolated five ones, as well as potential molecular mechani ...
DOI:
10.1080/14786419.2020.1844698

18. Dihydroartemisinin reduced lipid droplet deposition by YAP1 to promote the anti-PD-1 effect in hepatocellular carcinoma

Author:
Liyuan Hao; Yinglin Guo; Qing Peng; Zhiqin Zhang; Jingmin Ji; Yiwei Liu; Yu Xue; Caige Li; Kangning Zheng; Xinli Shi
Source:
Phytomedicine 2022 v.96 pp. 153913
ISSN:
0944-7113
Subject:
hepatoma,   etc   ; Western blotting; antimalarials; droplets; drug therapy; electron microscopy; immunohistochemistry; liver; medicine; protein synthesis;     Show all 10 Subjects
Abstract:
... Anti-PD-1 was used to treat for many cancers, but the overall response rate of monoclonal antibodies blocking the inhibitory PD-1/PD-L1 was less than 20%. Lipid droplet (LD) deposition reduced chemotherapy efficacy, but whether LD deposition affects anti-PD-1 treatment and its mechanism remains unclear. Dihydroartemisinin (DHA) was FDA proved antimalarial medicine, but its working mechanism on LD ...
DOI:
10.1016/j.phymed.2021.153913

19. Expression of glycosaminoglycans in cirrhotic liver and hepatocellular carcinoma—a pilot study including etiology

Author:
Gábor Tóth; Domonkos Pál; Simon Sugár; Ilona Kovalszky; Katalin Dezső; Gitta Schlosser; László Drahos; Lilla Turiák
Source:
Analytical and bioanalytical chemistry 2022 v.414 no.13 pp. 3837-3846
ISSN:
1618-2642
Subject:
hepatoma,   etc   ; analytical chemistry; chondroitin sulfate; etiology; heparan sulfate; hepatitis B; humans; liver; mortality; viruses;     Show all 10 Subjects
Abstract:
... Chronic liver diseases have both high incidence and mortality rates; therefore, a deeper understanding of the underlying molecular mechanisms is essential. We have determined the content and sulfation pattern of chondroitin sulfate (CS) and heparan sulfate (HS) in human hepatocellular carcinoma and cirrhotic liver tissues, considering the etiology of the diseases. A variety of pathological conditi ...
DOI:
10.1007/s00216-022-04025-3

20. Hepatitis B virus-associated hepatocellular carcinoma with Smc5/6 complex deficiency is susceptible to PARP inhibitors

Author:
Kazuyoshi Funato; Motoyuki Otsuka; Kazuma Sekiba; Yu Miyakawa; Takahiro Seimiya; Chikako Shibata; Takahiro Kishikawa; Mitsuhiro Fujishiro
Source:
Biochemical and biophysical research communications 2022 v.607 pp. 89-95
ISSN:
0006-291X
Subject:
hepatoma,   etc   ; DNA; DNA damage; DNA repair; chromosomes; hepatitis B; homologous recombination; regulatory proteins; research;     Show all 9 Subjects
Abstract:
... DNA repair processes represent attractive synthetic lethal targets because many cancers exhibit impaired DNA repair pathways, which leads to dependence on specific repair proteins. The finding that poly (ADP-ribose) polymerase (PARP)-1 inhibitors are highly effective against cancers with deficient homologous recombination highlights the potential of this approach. In hepatitis B viral (HBV) infect ...
DOI:
10.1016/j.bbrc.2022.03.137