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1. Laparoscopic access to the liver and application of laparoscopic microwave ablation in 2 dogs with liver neoplasia

Author:
Oramas, Alberto; Case, J. Brad; Toskich, Beau B.; Fox‐Alvarez, W. Alexander; Boston, Sarah E.; Giglio, Robson F.; Dark, Michael J.
Source:
Veterinary surgery 2019 v.48 no.S1 pp. O91
ISSN:
0161-3499
Subject:
hepatoma,   etc   ; dogs; hemangiosarcoma; histopathology; laparoscopy; liver; metastasis;     Show all 7 Subjects
Abstract:
... OBJECTIVE: To determine laparoscopic accessibility of liver lobes and access to the hilus and describe laparoscopic microwave ablation (LMWA) in 2 dogs with hepatic neoplasia. STUDY DESIGN: Experimental/descriptive case series. SAMPLE POPULATION: Six canine cadavers and 2 clinical dogs. METHODS: Cadavers in dorsal recumbency underwent laparoscopic assessment of the liver. A 17 gauge MWA probe was ...
DOI:
10.1111/vsu.13153

2. CXCL17 promotes cell metastasis and inhibits autophagy via the LKB1-AMPK pathway in hepatocellular carcinoma

Author:
Wang, Linpei; Li, Haitao; Zhen, Zuojun; Ma, Xiaoqiu; Yu, Waishi; Zeng, Huahuo; Li, Li
Source:
Gene 2019 v.690 pp. 129-136
ISSN:
0378-1119
Subject:
hepatoma,   etc   ; autophagy; biosynthesis; chemokines; enzymes; histology; liver; metastasis; phenotype;     Show all 9 Subjects
Abstract:
... As an innovative CXC chemokine, CXCL17 has a mysterious clinical significance and modulating influence on hepatocellular carcinoma (HCC). Our study examined the activity and mechanisms of CXCL17 on growth, autophagy, and metastasis of HCC. Upregulation of CXCL17 expression was observed in HCC, which is correlated with poorer histological stages and outcomes. Elevation of CXCL17 expression promoted ...
DOI:
10.1016/j.gene.2018.12.043

3. IL- 17A inhibits autophagic activity of HCC cells by inhibiting the degradation of Bcl2

Author:
Li, Sheng; Lin, Zhenwen; Zheng, Wang; Zheng, Lisheng; Chen, Xi; Yan, Zixing; Cheng, Zhuqin; Yan, Haiyi; Zheng, Cui; Guo, Peng
Source:
Biochemical and biophysical research communications 2019 v.509 no.1 pp. 194-200
ISSN:
0006-291X
Subject:
hepatoma,   etc   ; autophagy; dissociation; interleukin-17; prognosis; protective effect; starvation; viability;     Show all 8 Subjects
Abstract:
... Hepatocellular carcinoma (HCC) is associated with poor prognosis due to many unknowns about its inflammatory microenvironment. As a pivotal proinflammatory cytokine, IL-17A exerts a protective effect on the survival and function of HCC cells. It is widely accepted that IL-17A plays an important role in regulating autophagy. Bcl2, a key molecule promoting the survival of HCC cells, also plays an in ...
DOI:
10.1016/j.bbrc.2018.12.103

4. lncRNA HULC promotes the growth of hepatocellular carcinoma cells via stabilizing COX-2 protein

Author:
Xiong, Haojun; Li, Bo; He, Jintao; Zeng, Yijun; Zhang, Yan; He, Fengtian
Source:
Biochemical and biophysical research communications 2017
ISSN:
0006-291X
Subject:
hepatoma,   etc   ; carcinogenesis; neoplasm cells;     Show all 3 Subjects
Abstract:
... Highly upregulated in liver cancer (HULC), a lncRNA overexpressed in hepatocellular carcinoma (HCC), has been demonstrated to be involved in the carcinogenesis and progression of HCC. However, the mechanisms of HULC promoting the abnormal growth of HCC cells are still not well elucidated. In the present study, we for the first time demonstrated that HULC promoted the growth of HCC cells through el ...
DOI:
10.1016/j.bbrc.2017.06.103

5. Holo-Seq: single-cell sequencing of holo-transcriptome

Author:
Xiao, Zhengyun; Cheng, Guo; Jiao, Yang; Pan, Chen; Li, Ran; Jia, Danmei; Zhu, Jing; Wu, Chao; Zheng, Min; Jia, Junling
Source:
Genome biology 2018 v.19 no.1 pp. 163
ISSN:
1474-760X
Subject:
hepatoma,   etc   ; humans; messenger RNA; sequence analysis; transcriptome;     Show all 5 Subjects
Abstract:
... Current single-cell RNA-seq approaches are hindered by preamplification bias, loss of strand of origin information, and the inability to observe small-RNA and mRNA dual transcriptomes. Here, we introduce a single-cell holo-transcriptome sequencing (Holo-Seq) that overcomes all three hurdles. Holo-Seq has the same quantitative accuracy and uniform coverage with a complete strand of origin informati ...
DOI:
10.1186/s13059-018-1553-7

6. STIP1 is over-expressed in hepatocellular carcinoma and promotes the growth and migration of cancer cells

Author:
Luo, Xiaoling; Liu, Yuting; Ma, Shijie; Liu, Lei; Xie, Rui; Li, Miaomiao; Shen, Peng; Wang, Shaochuang
Source:
Gene 2018 v.662 pp. 110-117
ISSN:
0378-1119
Subject:
hepatoma,   etc   ; neoplasm cells; phosphoproteins; therapeutics; tissues;     Show all 5 Subjects
Abstract:
... Wnt/beta-catenin signaling is frequently activated in hepatocellular carcinoma (HCC). Better understanding the mechanism for its over-activation would help the therapy. In this study, we have shown that the stress-induced phosphoprotein 1 (STIP1) is up-regulated in the HCC tissues. Functional studies showed that STIP1 promoted the growth, colony formation and migration of cancer cells. However, kn ...
DOI:
10.1016/j.gene.2018.03.076

7. Knockout of NCOA5 impairs proliferation and migration of hepatocellular carcinoma cells by suppressing epithelial-to-mesenchymal transition

Author:
He, Jingcai; Zhang, Wan; Li, Aimin; Chen, Fengsheng; Luo, Rongcheng
Source:
Biochemical and biophysical research communications 2018 v.500 no.2 pp. 177-183
ISSN:
0006-291X
Subject:
hepatoma,   etc   ; epithelium; gene editing; microparticles; neoplasm cells;     Show all 5 Subjects
Abstract:
... Nuclear receptor coactivator 5 (NCOA5) plays important roles in the development of a variety of malignancies. However, the underlying mechanisms remain obscure. In this study, we successfully generated the NCOA5 knockout hepatocellular carcinoma (HCC) cells by CRISPR/Cas9 - mediated genome editing and found that knockout of NCOA5 inhibited the proliferation and tumor microsphere formation of HCC c ...
DOI:
10.1016/j.bbrc.2018.04.017

8. MiR-429 regulates the metastasis and EMT of HCC cells through targeting RAB23

Author:
Xue, Hongyan; Tian, Guo-Yan
Source:
Archives of biochemistry and biophysics 2018 v.637 pp. 48-55
ISSN:
0003-9861
Subject:
hepatoma,   etc   ; humans; metastasis; microRNA; signal transduction;     Show all 5 Subjects
Abstract:
... Accumulating documents have revealed that microRNAs (miRNAs) play critical roles in the development and progression of tumors. MiR-429 has been reported to be involved in regulating various cellular processes. However, its biological role and underlying mechanism in hepatocellular carcinoma (HCC) still need to be further studied. The present study aimed to investigate the function of miR-429 in th ...
DOI:
10.1016/j.abb.2017.11.011

9. miR-1260b promotes cell migration and invasion of hepatocellular carcinoma by targeting the regulator of G-protein signaling 22

Author:
Li, Xiaoying; Song, Hongxia; Liu, Zhirong; Bi, Yunsheng
Source:
Biotechnology letters 2018 v.40 no.1 pp. 57-62
ISSN:
0141-5492
Subject:
hepatoma,   etc   ; G-proteins; carcinogenesis; cell movement; tissues;     Show all 5 Subjects
Abstract:
... OBJECTIVES: To investigate whether miR-1260b can regulate migration and invasion of hepatocellular carcinoma (HCC) by targeting RGS22. RESULTS: miR-1260b was up-regulated in HCC tissues compared with their corresponding non-cancerous tissues. Over-expression of miR-1260b increased migration and invasion of HepG2 and SMMC-7721 cells associated with HCC. Regulator of G-protein signaling 22 (RGS22) w ...
DOI:
10.1007/s10529-017-2455-6

10. Poly(lactobionamidoethyl methacrylate)-based amphiphiles with ultrasound-labile components in manufacture of drug delivery nanoparticulates for augmented cytotoxic efficacy to hepatocellular carcinoma

Author:
Wang, Jingyun; Xia, Ying; Liu, Huiying; Xia, Jing; Qian, Ming; Zhang, Liuwei; Chen, Lili; Chen, Qixian
Source:
Journal of colloid and interface science 2019 v.551 pp. 1-9
ISSN:
0021-9797
Subject:
hepatoma,   etc   ; cytotoxicity; doxorubicin; drug delivery systems; drug therapy; hydrophilicity; hydrophobicity; manufacturing; receptors; surfactants; ultrasonic treatment;     Show all 11 Subjects
Abstract:
... Ultrasound-responsive chemistry was exploited in manufacture of drug delivery nanoparticulates for pursuit of on-demand ultrasound-stimulated drug release function. In principle, the ultrasound-labile oxyl-alkylhydroxylamine (-oa-) linkage was tailored between the segments of amphiphiles. Consequently, the hydrophobic chemotherapeutic doxorubicin could be readily assembled with the hydrophobic seg ...
DOI:
10.1016/j.jcis.2019.05.008

11. Effect of extract from ginseng rust rot on the inhibition of human hepatocellular carcinoma cells in vitro

Author:
Hu, Jing; Jiao, Jie; Wang, Ying; Gao, Mingyan; Lu, Zhengcheng; Yang, Fan; Hu, Cuihua; Song, Zhengxun; Chen, Yujuan; Wang, Zuobin
Source:
Micron 2019 v.124 pp. 102710
ISSN:
0968-4328
Subject:
hepatoma,   etc   ; Panax; actin; apoptosis; death; drug development; hepatocytes; humans; neoplasm cells; survival rate; traditional medicine;     Show all 11 Subjects
Abstract:
... Hepatocellular carcinoma (HCC) is one of major leading causes of cancer death worldwide. As a traditional medicine, the anti-cancer function of ginseng is being growingly recognized and investigated. However, the effect of ginseng rust rot on human HCC is unknown yet. In this study, the HCC cells were treated with different parts of mountain cultivated ginseng rust rot and compared with human norm ...
DOI:
10.1016/j.micron.2019.102710

12. The Oncogenic Action of NRF2 Depends on De-glycation by Fructosamine-3-Kinase

Author:
Sanghvi, Viraj R.; Leibold, Josef; Mina, Marco; Mohan, Prathibha; Berishaj, Marjan; Li, Zhuoning; Miele, Matthew M.; Lailler, Nathalie; Zhao, Chunying; de Stanchina, Elisa; Viale, Agnes; Akkari, Leila; Lowe, Scott W.; Ciriello, Giovanni; Hendrickson, Ronald C.; Wendel, Hans-Guido
Source:
Cell 2019 v.178 no.4 pp. 807-819.e21
ISSN:
0092-8674
Subject:
hepatoma,   etc   ; cysteine; enzymes; glycation; heat shock proteins; histones; mass spectrometry; phenotype; therapeutics; transcription factors; transcriptional activation;     Show all 11 Subjects
Abstract:
... The NRF2 transcription factor controls a cell stress program that is implicated in cancer and there is great interest in targeting NRF2 for therapy. We show that NRF2 activity depends on Fructosamine-3-kinase (FN3K)—a kinase that triggers protein de-glycation. In its absence, NRF2 is extensively glycated, unstable, and defective at binding to small MAF proteins and transcriptional activation. More ...
DOI:
10.1016/j.cell.2019.07.031

13. Simultaneous knockdown of YAP and TAZ increases apoptosis of hepatocellular carcinoma cells under hypoxic condition

Author:
Yan, Bin; Li, Tianyi; Shen, Ling; Zhou, Zhijie; Liu, Xueni; Wang, Xiaoliang; Sun, Xing
Source:
Biochemical and biophysical research communications 2019 v.515 no.2 pp. 275-281
ISSN:
0006-291X
Subject:
hepatoma,   etc   ; apoptosis; cell viability; digestive system; hypoxia; neoplasm cells; normoxia; signal transduction; survival rate;     Show all 9 Subjects
Abstract:
... Hepatocellular carcinoma (HCC) is one of the common malignant tumors of the digestive system and its five-year survival rate is low. Hypoxia is an important feature of HCC, which can promote cell death resistance. However, the key regulator of HCC cell survival remains elusive in the hypoxic condition. Emerging researches have showed that the Hippo signaling pathway is involved in the initiation a ...
DOI:
10.1016/j.bbrc.2019.05.143

14. MTA2 promotes HCC progression through repressing FRMD6, a key upstream component of hippo signaling pathway

Author:
Guan, Chengjian; Chang, Zhenyu; Gu, Xinjin; Liu, Rong
Source:
Biochemical and biophysical research communications 2019 v.515 no.1 pp. 112-118
ISSN:
0006-291X
Subject:
hepatoma,   etc   ; genes; humans; liver; metastasis; mortality; patients; signal transduction; transcription (genetics);     Show all 9 Subjects
Abstract:
... Discerning oncogenic drivers from passengers remains a major effort in understanding of the essence of the initiation and development of hepatocellular carcinoma (HCC), the most common primary liver malignancy and the third leading cause of cancer mortality worldwide. Here we report that MTA2, Metastasis Associated 1 Family Member 2, is significantly up-regulated in HCC. We show that high level of ...
DOI:
10.1016/j.bbrc.2019.05.025

15. Regulation of the Intracellular ROS Level Is Critical for the Antiproliferative Effect of Quercetin in the Hepatocellular Carcinoma Cell Line HepG2

Author:
Jeon, Ji-Sook; Kwon, Sora; Ban, Kiwon; Kwon Hong, Young-; Ahn, Curie; Sung, Jung-Suk; Choi, Inho
Source:
Nutrition and cancer 2019 v.71 no.5 pp. 861-869
ISSN:
1532-7914
Subject:
hepatoma,   etc   ; apoptosis; cell cycle checkpoints; human cell lines; hydrogen peroxide; neoplasm cells; quercetin; small interfering RNA;     Show all 8 Subjects
Abstract:
... Quercetin, an antioxidant flavonoid, has been known that it can induce the cell cycle arrest and apoptosis of hepatocellular carcinoma (HCC) cells by the stabilization or induction of p53. Here, we found that quercetin reduced the proliferation of HepG2 cells significantly, but not Huh7 cells. Interestingly, quercetin down-regulated the intracellular ROS level in HepG2 cells, but not Huh7 cells. F ...
DOI:
10.1080/01635581.2018.1559929

16. Eschatological scrutiny of unprofessional usage of molecular docking; how unreliability in computational methods arises from amateurish mistakes

Author:
Bagheri, Milad; Ghasemshirazi, Saeid; Abiri, Ardavan
Source:
Biocatalysis and agricultural biotechnology 2019 v.20 pp. 101224
ISSN:
1878-8181
Subject:
hepatoma,   etc   ; agricultural biotechnology; apoptosis; astaxanthin; biocatalysis; computational methodology; computer simulation; cost effectiveness; drug design; ligands; proteins;     Show all 11 Subjects
Abstract:
... The impact of computational methods in drug design and discovery is prevailing in both academic and industrial scales. Molecular docking is one of the favorite tools for assessment of the interactions between a ligand and its congener macromolecule. In silico approaches and especially molecular docking are gaining much attention in recent years due to their cost-effective nature. In this letter to ...
DOI:
10.1016/j.bcab.2019.101224

17. A new coumarin from Juglans mandshurica Maxim induce apoptosis in hepatocarcinoma cells

Author:
Lou, Li-Li; Zhao, Peng; Cheng, Zhuo-Yang; Guo, Rui; Yao, Guo-Dong; Wang, Xiao-Bo; Huang, Xiao-Xiao; Song, Shao-Jiang
Source:
Natural product research 2019 v.33 no.12 pp. 1791-1793
ISSN:
1478-6427
Subject:
hepatoma,   etc   ; Juglans mandshurica; apoptosis; bark; chemical structure; coumarin; cytotoxicity; humans; inhibitory concentration 50; spectral analysis; staining;     Show all 11 Subjects
Abstract:
... In this study, a new coumarin, juglansoside C (1) was isolated from the bark of Juglans mandshurica. Its chemical structure was identified by comprehensive spectroscopic analyses. The in vitro cytotoxicity assay showed that 1 exhibited moderate cytotoxicity against human hepatocellular carcinoma Hep3B cells with an IC₅₀ value of 70.9 μM. Furthermore, Annexin V-FITC/PI staining assay indicated that ...
DOI:
10.1080/14786419.2018.1434646

18. Pretumor microenvironment of hepatocellular carcinoma: Cancerization or anticancerization?

Author:
Li, Genliang; Ni, Anni; Yu, Mengyao
Source:
Gene 2019 v.701 pp. 46-54
ISSN:
0378-1119
Subject:
hepatoma,   etc   ; alternative splicing; genes; immunity; liver; metastasis; mice; neoplasm cells; sequence analysis; subcutaneous injection; transcriptome;     Show all 11 Subjects
Abstract:
... Tumor microenvironment (TM) has been deeply concerned. However, the pretumor microenvironment (PTM) was poorly understood. The purpose in this study was to explore the possible pathophysiological features of PTM before hepatocellular carcinoma (HCC) appearance.Mouse livers with no swelling but with tumors present elsewhere in the body after subcutaneous injection of H22 in the fore underarm were c ...
DOI:
10.1016/j.gene.2019.03.034

19. Detection of Total Aflatoxins in Groundnut and Soybean Samples in Yemen Using Enzyme-Linked Immunosorbent Assay

Author:
Ahmed Abdullah Murshed, Safwan; Bacha, Nafees; Alharazi, Talal
Source:
Journal of food quality 2019 v.2019
ISSN:
1745-4557
Subject:
hepatoma,   etc   ; aflatoxins; carcinogenicity; enzyme-linked immunosorbent assay; mutagens; peanuts; public health; soybeans; Yemen;     Show all 9 Subjects
Abstract:
... Aflatoxins are fungal toxins that have mutagenic and carcinogenic effects, especially hepatocellular carcinoma effect. This work aimed to investigate the presence of aflatoxins in groundnuts and soybeans that are consumed in Yemen. The samples were collected from three different regions in Yemen (Sana’a, al-Hodeida, and Aden), and they were divided into two groups. The concentration of total aflat ...
DOI:
10.1155/2019/1614502

20. Prognostic biomarker AASS suppresses proliferation, migration and predicts a good survival of hepatocellular carcinoma in vivo and in vitro

Author:
Xue, Feng; Shi, Chunchao; Yang, Lixue; Li, Chenqi; Liu, Yang; Sun, Yanfu; Ge, Ruiliang
Source:
Life sciences 2019
ISSN:
0024-3205
Subject:
hepatoma,   etc   ; biomarkers; data collection; embolism; enzymes; genes; graphs; in vitro studies; metabolism; prognosis; therapeutics; tissues;     Show all 12 Subjects
Abstract:
... Hepatocellular carcinoma (HCC) is one of the most heterogeneous cancers worldwide, finding novel validate prognostic biomarker is the aim of this work.Expression of AASS (aminoadipate-semialdehyde synthase) was assayed in three independent cohorts, and the diagnostic and prognostic values of this gene was also evaluated. Clinical indicators significantly associated with AASS were also analyzed. In ...
DOI:
10.1016/j.lfs.2019.05.080