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1. Causality in medicine

Author:
Bach, Jean-François
Source:
Comptes rendus 2019 v.342 no.3-4 pp. 55-57
ISSN:
1631-0691
Subject:
human diseases,   etc   ; medicine; patients; therapeutics;     Show all 4 Subjects
Abstract:
... This article is the result of a symposium organized at the French Academy of Sciences on May 31, 2016, entitled: Do we need to know the causes to understand and intervene? Questions on causality in the biological and medical sciences, and published in French in a book entitled: Causality in the biological and medical sciences (EDP Sciences, 2017). ...
DOI:
10.1016/j.crvi.2019.03.001

2. Commitment Isn’t for Everyone

Author:
Josling, Gabrielle A.; Llinás, Manuel
Source:
Trends in parasitology 2019 v.35 no.6 pp. 381-383
ISSN:
1471-4922
Subject:
human diseases,   etc   ; Culicidae; gametocytes; malaria; parasites;     Show all 5 Subjects
Abstract:
... The majority of malaria parasites during human infection are asexual and are unable to be transmitted to mosquitoes. Only sexually differentiated parasites (gametocytes) can be successfully transmitted to complete the lifecycle. In a recent study by Bancells et al. (Nat. Microbiol. 2019;4:144–154), a new route of sexual conversion is identified that does not require a prior round of replication. ...
DOI:
10.1016/j.pt.2019.03.012

3. miRNA inhibition by proximity-enabled Dicer inactivation

Author:
Yan, Hao; Liang, Fu-Sen
Source:
Methods 2019
ISSN:
1046-2023
Subject:
human diseases,   etc   ; biogenesis; medicinal properties; microRNA; therapeutics;     Show all 5 Subjects
Abstract:
... microRNAs (miRNAs) are considered as master regulators of biological processes. Dysregulation of miRNA expression has been implicated in many human diseases. Driven by the key biological roles and the therapeutic potential, developing methods for miRNA regulation has become an intense research area. Due to favorable pharmacological properties, small molecule-based miRNA inhibition emerges as a pro ...
DOI:
10.1016/j.ymeth.2019.05.004

4. Pharmacologically evoked apnoeas. Receptors and nervous pathways involved

Author:
Szereda-Przestaszewska, Małgorzata; Kaczyńska, Katarzyna
Source:
Life sciences 2019 v.217 pp. 237-242
ISSN:
0024-3205
Subject:
human diseases,   etc   ; apnea; breathing; narcotics; serotonin receptors;     Show all 5 Subjects
Abstract:
... This review analyses the knowledge about the incidence of transient apnoeic spells, induced by substances which activate vagal chemically sensitive afferents. It considers the specificity and expression of appropriate receptors, and relevant research on pontomedullary circuits contributing to a cessation of respiration. Insight is gained into an excitatory drive of 5-HT1A serotonin receptors in ov ...
DOI:
10.1016/j.lfs.2018.12.021

5. Correction to: The role of proteomics in the age of immunotherapies

Author:
Hayes, Sarah A.; Clarke, Stephen; Pavlakis, Nick; Howell, Viive M.
Source:
Mammalian genome 2018 v.29 no.11-12 pp. 770
ISSN:
0938-8990
Subject:
human diseases,   etc   ; immunotherapy; proteome; proteomics;     Show all 4 Subjects
Abstract:
... Some parts of the Abstract, Introduction and Discussion included uncited text from the following previously published chapter. ...
DOI:
10.1007/s00335-018-9785-0

6. Correction to: Characterization of biomarkers in stroke based on ego-networks and pathways

Author:
Li, Haixia; Guo, Qian
Source:
Biotechnology letters 2018 v.40 no.9-10 pp. 1437
ISSN:
0141-5492
Subject:
human diseases,   etc   ; biomarkers; biotechnology; stroke;     Show all 4 Subjects
Abstract:
... In the original publication of the article, the second author name was published incorrectly. The corrected author name is given in this correction. ...
DOI:
10.1007/s10529-018-2590-8

7. Structural Ensemble Modulation upon Small-Molecule Binding to Disordered Proteins

Author:
Heller, Gabriella T.; Bonomi, Massimiliano; Vendruscolo, Michele
Source:
Journal of molecular biology 2018 v.430 no.16 pp. 2288-2292
ISSN:
0022-2836
Subject:
human diseases,   etc   ; models; proteins; therapeutics;     Show all 4 Subjects
Abstract:
... Over the past decade, there has been a growing interest in investigating whether disordered proteins can be targeted for clinical purposes using small molecules [1–8]. While small-molecule binding to disordered proteins can be seen as unorthodox, examples of this phenomenon have been reported. In order to rationalize these observations, a variety of models are emerging, sometimes in apparent contr ...
DOI:
10.1016/j.jmb.2018.03.015

8. Exploring human host–microbiome interactions in health and disease—how to not get lost in translation

Author:
Lebeer, Sarah; Spacova, Irina
Source:
Genome biology 2019 v.20 no.1 pp. 56
ISSN:
1474-760X
Subject:
human diseases,   etc   ; host-pathogen relationships; human health; humans;     Show all 4 Subjects
Abstract:
... A meeting report on the 7th Wellcome Trust conference on Exploring Human Host–Microbiome Interactions in Health and Disease, held at Hinxton, UK, 5–7 December 2018. ...
DOI:
10.1186/s13059-019-1669-4

9. Codon and Codon-Pair Usage Tables (CoCoPUTs): Facilitating Genetic Variation Analyses and Recombinant Gene Design

Author:
Alexaki, Aikaterini; Kames, Jacob; Holcomb, David D.; Athey, John; Santana-Quintero, Luis V.; Lam, Phuc Vihn Nguyen; Hamasaki-Katagiri, Nobuko; Osipova, Ekaterina; Simonyan, Vahan; Bar, Haim; Komar, Anton A.; Kimchi-Sarfaty, Chava
Source:
Journal of molecular biology 2019 v.431 no.13 pp. 2434-2441
ISSN:
0022-2836
Subject:
human diseases,   etc   ; codons; databases; genetic variation; genomics; pharmaceutical industry; statistics;     Show all 7 Subjects
Abstract:
... Usage of sequential codon-pairs is non-random and unique to each species. Codon-pair bias is related to but clearly distinct from individual codon usage bias. Codon-pair bias is thought to affect translational fidelity and efficiency and is presumed to be under the selective pressure. It was suggested that changes in codon-pair utilization may affect human disease more significantly than changes i ...
DOI:
10.1016/j.jmb.2019.04.021

10. Weighted matrix factorization on multi-relational data for LncRNA-disease association prediction

Author:
Wang, Yuehui; Yu, Guoxian; Wang, Jun; Fu, Guangyuan; Guo, Maozu; Domeniconi, Carlotta
Source:
Methods 2019
ISSN:
1046-2023
Subject:
human diseases,   etc   ; genes; models; non-coding RNA; prediction;     Show all 5 Subjects
Abstract:
... Influx evidences show that red long non-coding RNAs (lncRNAs) play important roles in various critical biological processes, and they afffect the development and progression of various human diseases. Therefore, it is necessary to precisely identify the lncRNA-disease associations. The identification precision can be improved by developing data integrative models. However, current models mainly ne ...
DOI:
10.1016/j.ymeth.2019.06.015

11. Dual Role of Ribosome-Binding Domain of NAC as a Potent Suppressor of Protein Aggregation and Aging-Related Proteinopathies

Author:
Shen, Koning; Gamerdinger, Martin; Chan, Rebecca; Gense, Karina; Martin, Esther M.; Sachs, Nadine; Knight, Patrick D.; Schlömer, Renate; Calabrese, Antonio N.; Stewart, Katie L.; Leiendecker, Lukas; Baghel, Ankit; Radford, Sheena E.; Frydman, Judith; Deuerling, Elke
Source:
Molecular cell 2019 v.74 no.4 pp. 729-741.e7
ISSN:
1097-2765
Subject:
human diseases,   etc   ; biogenesis; eukaryotic cells; luciferase; models; mutants; protein synthesis;     Show all 7 Subjects
Abstract:
... The nascent polypeptide-associated complex (NAC) is a conserved ribosome-associated protein biogenesis factor. Whether NAC exerts chaperone activity and whether this function is restricted to de novo protein synthesis is unknown. Here, we demonstrate that NAC directly exerts chaperone activity toward structurally diverse model substrates including polyglutamine (PolyQ) proteins, firefly luciferase ...
DOI:
10.1016/j.molcel.2019.03.012

12. ATG8-Binding UIM Proteins Define a New Class of Autophagy Adaptors and Receptors

Author:
Marshall, Richard S.; Hua, Zhihua; Mali, Sujina; McLoughlin, Fionn; Vierstra, Richard D.
Source:
Cell 2019 v.177 no.3 pp. 766-781.e24
ISSN:
0092-8674
Subject:
human diseases,   etc   ; autophagy; humans; hydrophobicity; receptors; ubiquitin; yeasts;     Show all 7 Subjects
Abstract:
... During autophagy, vesicle dynamics and cargo recruitment are driven by numerous adaptors and receptors that become tethered to the phagophore through interactions with lipidated ATG8/LC3 decorating the expanding membrane. Most currently described ATG8-binding proteins exploit a well-defined ATG8-interacting motif (AIM, or LC3-interacting region [LIR]) that contacts a hydrophobic patch on ATG8 know ...
DOI:
10.1016/j.cell.2019.02.009

13. Animal models of fatigue in major depressive disorder

Author:
Stutz, Patrick V.; Golani, Lalit Kumar; Witkin, Jeffrey M.
Source:
Physiology & behavior 2019 v.199 pp. 300-305
ISSN:
0031-9384
Subject:
human diseases,   etc   ; animal models; behavior disorders; drugs; humans; mental depression;     Show all 6 Subjects
Abstract:
... Fatigue is common in a host of neurological and psychiatric disorders including depression and often continues unabated even after primary symptoms of disease are treated. Its high estimated prevalence combined with the lack of effective medicines has engaged the preclinical research community to search for fatigue models. The present review briefly summarizes the most common animal models that ha ...
DOI:
10.1016/j.physbeh.2018.11.042

14. PXE, a Mysterious Inborn Error Clarified

Author:
Borst, Piet; Váradi, András; van de Wetering, Koen
Source:
Trends in biochemical sciences 2019 v.44 no.2 pp. 125-140
ISSN:
0968-0004
Subject:
human diseases,   etc   ; animal physiology; biochemistry; calcification; inherited metabolic diseases;     Show all 5 Subjects
Abstract:
... Ever since Garrod deduced the existence of inborn errors in 1901, a vast array of metabolic diseases has been identified and characterized in molecular terms. In 2018 it is difficult to imagine that there is any uncharted backyard left in the metabolic disease landscape. Nevertheless, it took until 2013 to identify the cause of a relatively frequent inborn error, pseudoxanthoma elasticum (PXE), a ...
DOI:
10.1016/j.tibs.2018.10.005

15. Fluorogenic probes for disease-relevant enzymes

Author:
ZhangEqual contribution., Junji; Chai, Xianzhi; He, Xiao-Peng; Kim, Hae-Jo; Yoon, Juyoung; Tian, He
Source:
Chemical Society reviews 2019 v.48 no.2 pp. 683-722
ISSN:
1460-4744
Subject:
human diseases,   etc   ; amino acids; carbohydrates; enzymes; immunoassays; lipids; peptides; proteins;     Show all 8 Subjects
Abstract:
... Traditional biochemical methods for enzyme detection are mainly based on antibody-based immunoassays, which lack the ability to monitor the spatiotemporal distribution and, in particular, the in situ activity of enzymes in live cells and in vivo. In this review, we comprehensively summarize recent progress that has been made in the development of small-molecule as well as material-based fluorogeni ...
DOI:
10.1039/c7cs00907k

16. Bacteriophage therapy as an alternative treatment for human infections. A comprehensive review

Author:
Kakasis, Athanasios; Panitsa, Gerasimia
Source:
International journal of antimicrobial agents 2019 v.53 no.1 pp. 16-21
ISSN:
0924-8579
Subject:
human diseases,   etc   ; antibiotic resistance; bacteria; bacteriophages; penicillins; phage therapy; USSR;     Show all 7 Subjects
Abstract:
... Bacteriophages, or phages, are viruses that infect bacteria. They were discovered around a century ago and have been used ever since for therapeutic purposes, particularly in former Soviet Union countries. Their use in Western countries was abandoned after the discovery and broad use of penicillin. The rising problem of antimicrobial resistance has revived interest in bacteriophage therapy. The ai ...
DOI:
10.1016/j.ijantimicag.2018.09.004

17. The trypan blue cellular debris assay: a novel low-cost method for the rapid quantification of cell death

Author:
Lebeau, Paul F.; Chen, Jack; Byun, Jae Hyun; Platko, Khrystyna; Austin, Richard C.
Source:
MethodsX 2019 v.6 pp. 1174-1180
ISSN:
2215-0161
Subject:
human diseases,   etc   ; cell death; cost effectiveness; lactate dehydrogenase; staining;     Show all 5 Subjects
Abstract:
... Cell death is a common driver of human disease and is frequently studied in a variety of in vitro settings. There currently exists a range of commercially available assays to examine cell death, however, most are costly and require assay-specific experimental conditions that may not be suitable for many cell types. Here, we show that cellular debris occurring as a result of cell death can be used ...
DOI:
10.1016/j.mex.2019.05.010

18. Deciphering the Sharp Decrease in H7N9 Human Infections

Author:
Zhang, Xu; Luo, Tingting; Shen, Yongyi
Source:
Trends in microbiology 2018 v.26 no.12 pp. 971-973
ISSN:
0966-842X
Subject:
human diseases,   etc   ; chickens; poultry diseases; vaccines; viruses;     Show all 5 Subjects
Abstract:
... The H7N9 virus has caused five waves of human infections since 2013. However, human infections have almost disappeared in the past year. In a recent study, Shi et al. revealed that the usage of a bivalent H5/H7 vaccine successfully prevented chicken infections, and thus prevented, and nearly eliminated, human infections. ...
DOI:
10.1016/j.tim.2018.10.002

19. Correction: The potential of paper-based diagnostics to meet the ASSURED criteria

Author:
Smith, Suzanne; Korvink, Jan G.; Mager, Dario; Land, Kevin
Source:
RSC advances 2018 v.8 no.66 pp. 37841
ISSN:
2046-2069
Subject:
human diseases,   etc   ; diagnostic techniques; paper; quality control;     Show all 4 Subjects
Abstract:
... Correction for ‘The potential of paper-based diagnostics to meet the ASSURED criteria’ by Suzanne Smith et al., RSC Adv., 2018, 8, 34012–34034. ...
DOI:
10.1039/c8ra90082e

20. SnapShot: Biology of Genetic Ataxias

Author:
Eidhof, Ilse; van de Warrenburg, Bart P.; Schenck, Annette
Source:
Cell 2018 v.175 no.3 pp. 890
ISSN:
0092-8674
Subject:
human diseases,   etc   ; ataxia (disorder); cerebellum; genetic disorders;     Show all 4 Subjects
Abstract:
... Genetic ataxias are a clinically important group of disabling, mostly neurodegenerative, diseases of the cerebellum. This SnapShot shows that the vast majority of established monogenic causes of dominant and recessive ataxias can be captured by a limited number of affected cellular components and biological processes in the cerebellum. To view this SnapShot, open or download the PDF. ...
DOI:
10.1016/j.cell.2018.10.017