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1. Strategies to Facilitate Translational Advances from Microbiome Surveys

Author:
Willis, Amy D.; Minot, Samuel S.
Source:
Trends in microbiology 2020 v.28 no.5 pp. 329-330
ISSN:
0966-842X
Subject:
human diseases,   etc   ; microbiome; surveys; therapeutics;     Show all 4 Subjects
Abstract:
... Manipulating the microbiome has enormous potential to treat important human diseases. Microbiome surveys are often used to identify potential therapeutic targets by finding associations between microbial elements and disease status. We argue that many reported associations between the microbiome and disease are incompatible with translational research because they are insufficiently specific. We e ...
DOI:
10.1016/j.tim.2020.02.002

2. N-Terminal Proteoforms in Human Disease

Author:
Bogaert, Annelies; Fernandez, Esperanza; Gevaert, Kris
Source:
Trends in biochemical sciences 2020 v.45 no.4 pp. 308-320
ISSN:
0968-0004
Subject:
human diseases,   etc   ; alternative splicing; genes; humans; therapeutics;     Show all 5 Subjects
Abstract:
... The collection of chemically different protein variants, or proteoforms, by far exceeds the number of protein-coding genes in the human genome. Major contributors are alternative splicing and protein modifications. In this review, we focus on those proteoforms that differ at their N termini with a molecular link to disease. We describe the main underlying mechanisms that give rise to such N-termin ...
DOI:
10.1016/j.tibs.2019.12.009

3. Defective Interfering Particles of Negative-Strand RNA Viruses

Author:
Ziegler, Christopher M.; Botten, Jason W.
Source:
Trends in microbiology 2020 v.28 no.7 pp. 554-565
ISSN:
0966-842X
Subject:
human diseases,   etc   ; Respiratory syncytial virus; disease severity; genome; influenza;     Show all 5 Subjects
Abstract:
... Viral defective interfering particles (DIPs) were intensely studied several decades ago but research waned leaving open many critical questions. New technologies and other advances led to a resurgence in DIP studies for negative-strand RNA viruses. While DIPs have long been recognized, their exact contribution to the outcome of acute or persistent viral infections has remained elusive. Recent stud ...
DOI:
10.1016/j.tim.2020.02.006

4. The role of monocytes/macrophages in Leishmania infection: A glance at the human response

Author:
Loría-Cervera, Elsy Nalleli; Andrade-Narvaez, Fernando
Source:
Acta tropica 2020 v.207 pp. 105456
ISSN:
0001-706X
Subject:
human diseases,   etc   ; Leishmania; Phlebotominae; humans; leishmaniasis; macrophages; mice; monocytes; parasites;     Show all 9 Subjects
Abstract:
... Leishmania are obligate intracellular parasites of mononuclear phagocytes transmitted by Phlebotomine sandflies. Monocytes are one of the main cell types recruited to the site of the bite having an important role in the defense against Leishmania parasites in the first hours of infection. In the tissue, macrophages play a pivotal role as both the primary replication sites and the major effector ce ...
DOI:
10.1016/j.actatropica.2020.105456

5. Highly responsive and rapid hydrogen peroxide-triggered degradation of polycaprolactone nanoparticles

Author:
Hsu, Peng-Hao; Arboleda, Carina; Stubelius, Alexandra; Li, Ling-Wei; Olejniczak, Jason; Almutairi, Adah
Source:
Biomaterials science 2020 v.8 no.9 pp. 2394-2397
ISSN:
2047-4849
Subject:
human diseases,   etc   ; depolymerization; hydrogen; hydrogen peroxide; lactones; nanoparticles; polymers;     Show all 7 Subjects
Abstract:
... We synthesized an oxidation-responsive polycaprolactone (O-PCL) bearing pendant arylboronic esters as H₂O₂-responsive motifs. H₂O₂ induces fast depolymerization of O-PCL within days. Nanoparticles formulated from O-PCL disintegrate and release payload in response to concentrations of H₂O₂ (50 μM) that are relevant to human disease. ...
DOI:
10.1039/c9bm02019e

6. Evolving challenges to model human diseases for translational research

Author:
Beck, Amanda P.; Meyerholz, David K.
Source:
Cell and tissue research 2020 v.380 no.2 pp. 305-311
ISSN:
0302-766X
Subject:
human diseases,   etc   ; animal models; biomedical research; funding; landscapes; swine;     Show all 6 Subjects
Abstract:
... Animal models are a significant component of biomedical research and play an important role in translational studies. Traditionally, rodent models have been the mainstay and principal choice of researchers but in recent years, there have been significant changes in the landscape of animal modeling. For example, newer techniques have greatly expanded the use and successful application of large anim ...
DOI:
10.1007/s00441-019-03134-3

7. Outlining the Complex Pathway of Mammalian Fe-S Cluster Biogenesis

Author:
Maio, Nunziata; Rouault, Tracey A.
Source:
Trends in biochemical sciences 2020 v.45 no.5 pp. 411-426
ISSN:
0968-0004
Subject:
human diseases,   etc   ; apoproteins; biogenesis; genes; inheritance (genetics); mammals; mitochondria;     Show all 7 Subjects
Abstract:
... Iron–sulfur (Fe-S) clusters (ISCs) are ubiquitous cofactors essential to numerous fundamental cellular processes. Assembly of ISCs and their insertion into apoproteins involves the function of complex cellular machineries that operate in parallel in the mitochondrial and cytosolic/nuclear compartments of mammalian cells. The spectrum of diseases caused by inherited defects in genes that encode the ...
DOI:
10.1016/j.tibs.2020.02.001

8. Rapidly training African giant pouched rats (Cricetomys ansorgei) with multiple targets for scent detection

Author:
Webb, Elisabeth K.; Saccardo, Caterina Caneva; Poling, Alan; Cox, Christophe; Fast, Cynthia D.
Source:
Behavioural processes 2020 v.174 pp. 104085
ISSN:
0376-6357
Subject:
human diseases,   etc   ; Cricetomys; extinction; nonprofit corporations; odors; rats; tuberculosis; Tanzania;     Show all 8 Subjects
Abstract:
... Since 1997, APOPO, a non-profit organization based in Tanzania, has deployed African giant pouched rats (Cricetomys ansorgei) to detect landmines in post-conflict areas. More recent research suggests the pouched rats can also be trained to detect tuberculosis in human sputum samples. Despite proven success on both tasks, the potential impact of each rat is limited by the required training time and ...
DOI:
10.1016/j.beproc.2020.104085

9. Unveiling the Origin and Transmission of 2019-nCoV

Author:
Xu, Yifei
Source:
Trends in microbiology 2020 v.28 no.4 pp. 239-240
ISSN:
0966-842X
Subject:
human diseases,   etc   ; Coronavirinae; control methods; public health; China;     Show all 5 Subjects
Abstract:
... A novel coronavirus has caused thousands of human infections in China since December 2019, raising a global public health concern. Recent studies (Huang et al., Chan et al., and Zhou et al.) have provided timely insights into its origin and ability to spread among humans, informing infection prevention and control practices. ...
DOI:
10.1016/j.tim.2020.02.001
PubMed:
32155431
PubMed Central:
PMC7126210

10. Heuristic filter feature selection methods for medical datasets

Author:
Alirezanejad, Mehdi; Enayatifar, Rasul; Motameni, Homayun; Nematzadeh, Hossein
Source:
Genomics 2020 v.112 no.2 pp. 1173-1181
ISSN:
0888-7543
Subject:
human diseases,   etc   ; computer analysis; data collection; genes; human genetics;     Show all 5 Subjects
Abstract:
... Gene selection is the process of selecting the optimal feature subset in an arbitrary dataset. The significance of gene selection is in high dimensional datasets in which the number of samples and features are low and high respectively. The major goals of gene selection are increasing the accuracy, finding the minimal effective feature subset, and increasing the performance of evaluations. This pa ...
DOI:
10.1016/j.ygeno.2019.07.002

11. PattRec: An easy-to-use CNV detection tool optimized for targeted NGS assays with diagnostic purposes

Author:
Roca, Iria; González-Castro, Lorena; Maynou, Joan; Palacios, Lourdes; Fernández, Helena; Couce, Mª Luz; Fernández-Marmiesse, Ana
Source:
Genomics 2020 v.112 no.2 pp. 1245-1256
ISSN:
0888-7543
Subject:
human diseases,   etc   ; bioinformatics; computer software; databases; high-throughput nucleotide sequencing;     Show all 5 Subjects
Abstract:
... Genetic laboratories use custom-commercial targeted next-generation sequencing (tg-NGS) assays to identify disease-causing variants. Although the high coverage achieved with these tests allows for the detection of copy number variants (CNVs), which account for an important proportion of the genetic burden in human diseases, an easy-to-use tool for automatic CNV detection is still lacking. This art ...
DOI:
10.1016/j.ygeno.2019.07.011

12. Polymicrobial interactions involving fungi and their importance for the environment and in human disease

Author:
Azzam, Seham Z.; Cayme, Ginelle J.; Martinez, Luis R.
Source:
Microbial pathogenesis 2020 v.140 pp. 103942
ISSN:
0882-4010
Subject:
human diseases,   etc   ; antibiotic resistance; drought; etiological agents; fungi; hosts; humans;     Show all 7 Subjects
Abstract:
... Understanding polymicrobial interactions involving fungi in the environment and the human mycobiome is necessary to address environmental and medically related problems such as drought or antimicrobial resistance. The diversity of these interactions highlights the complexity of fungi, considering how some interactions can be antagonistic, while others synergistic. Over the years, an increase in st ...
DOI:
10.1016/j.micpath.2019.103942
PubMed:
31881258
PubMed Central:
PMC7105396

13. Ancient Echinostome Eggs Discovered in Archaeological Strata Specimens from a Baekje Capital Ruins of South Korea

Author:
Seo, Min; Shim, Sang-Yuck; Lee, Hwa Young; Kim, Yongjun; Hong, Jong Ha; Kim, Ji Eun; Chai, Jong-Yil; Shin, Dong Hoon
Source:
TheJournal of parasitology 2020 v.106 no.1 pp. 184-187
ISSN:
0022-3395
Subject:
human diseases,   etc   ; Koreans; archaeology; echinostomiasis; eggs; indigenous species; South Korea;     Show all 7 Subjects
Abstract:
... Echinostomiasis is prevalent in southeastern as well as northeastern Asian countries. This endemicity notwithstanding, no echinostome egg has as yet been reported by paleoparasitological studies conducted in Asian countries. Recently we analyzed geological-strata specimens retrieved from the ancient capital city of the Baekje Kingdom to uncover clues to the possible prevalence of echinostomiasis a ...
DOI:
10.1645/19-55

14. Weighted matrix factorization on multi-relational data for LncRNA-disease association prediction

Author:
Wang, Yuehui; Yu, Guoxian; Wang, Jun; Fu, Guangyuan; Guo, Maozu; Domeniconi, Carlotta
Source:
Methods 2020 v.173 pp. 32-43
ISSN:
1046-2023
Subject:
human diseases,   etc   ; genes; models; non-coding RNA; prediction;     Show all 5 Subjects
Abstract:
... Influx evidences show that red long non-coding RNAs (lncRNAs) play important roles in various critical biological processes, and they afffect the development and progression of various human diseases. Therefore, it is necessary to precisely identify the lncRNA-disease associations. The identification precision can be improved by developing data integrative models. However, current models mainly ne ...
DOI:
10.1016/j.ymeth.2019.06.015

15. Staphylococcus sciuri peritonitis in a patient on peritoneal dialysis

Author:
Meservey, Amber; Sullivan, Alexander; Wu, Christine; Lantos, Paul M.
Source:
Zoonoses and public health 2020 v.67 no.1 pp. 93-95
ISSN:
1863-1959
Subject:
human diseases,   etc   ; Staphylococcus sciuri; animals; dialysis; flora; patients; peritonitis;     Show all 7 Subjects
Abstract:
... Staphylococcus sciuri is an occasional cause of human infection that has been described in the flora of numerous animal species and in environmental specimens. Here, we report a rare case of S. sciuri peritonitis in a dialysis patient who had exposure to peridomestic animals. ...
DOI:
10.1111/zph.12664

16. Establishing or Exaggerating Causality for the Gut Microbiome: Lessons from Human Microbiota-Associated Rodents

Author:
Walter, Jens; Armet, Anissa M.; Finlay, B. Brett; Shanahan, Fergus
Source:
Cell 2020 v.180 no.2 pp. 221-232
ISSN:
0092-8674
Subject:
human diseases,   etc   ; humans; intestinal microorganisms; microbiome; phenotype; rodents; systematic review;     Show all 7 Subjects
Abstract:
... Human diseases are increasingly linked with an altered or “dysbiotic” gut microbiota, but whether such changes are causal, consequential, or bystanders to disease is, for the most part, unresolved. Human microbiota-associated (HMA) rodents have become a cornerstone of microbiome science for addressing causal relationships between altered microbiomes and host pathology. In a systematic review, we f ...
DOI:
10.1016/j.cell.2019.12.025

17. Comparative effects of oncogenic mutations G12C, G12V, G13D, and Q61H on local conformations and dynamics of K-Ras

Author:
Vatansever, Sezen; Erman, Burak; Gümüş, Zeynep H.
Source:
Computational and Structural Biotechnology Journal 2020 v.18 pp. 1000-1011
ISSN:
2001-0370
Subject:
human diseases,   etc   ; molecular dynamics; mutants; mutation; neoplasms; patients;     Show all 6 Subjects
Abstract:
... K-Ras is the most frequently mutated protein in human cancers. However, until very recently, its oncogenic mutants were viewed as undruggable. To develop inhibitors that directly target oncogenic K-Ras mutants, we need to understand both their mutant-specific and pan-mutant dynamics and conformations. Recently, we have investigated how the most frequently observed K-Ras mutation in cancer patients ...
DOI:
10.1016/j.csbj.2020.04.003
PubMed:
32373288
PubMed Central:
PMC7191603

18. Causality in medicine

Author:
Bach, Jean-François
Source:
Comptes rendus 2019 v.342 no.3-4 pp. 55-57
ISSN:
1631-0691
Subject:
human diseases,   etc   ; medicine; patients; therapeutics;     Show all 4 Subjects
Abstract:
... This article is the result of a symposium organized at the French Academy of Sciences on May 31, 2016, entitled: Do we need to know the causes to understand and intervene? Questions on causality in the biological and medical sciences, and published in French in a book entitled: Causality in the biological and medical sciences (EDP Sciences, 2017). ...
DOI:
10.1016/j.crvi.2019.03.001

19. Intein-mediated recombinant expression of monomeric B22Asp desB30 insulin

Author:
Zhang, Minmin; Zhang, Yunlong; Wu, Bingnan; Peng, Yanhao; Simair, Altaf Ahmed; Siegel, Geoffery W.; Lu, Changrui; Chen, Ting
Source:
BMC biotechnology 2020 v.20 no.1 pp. 3
ISSN:
1472-6750
Subject:
human diseases,   etc   ; Escherichia coli; bacteria; chitin; diabetes; hyperglycemia; insulin; manufacturing; pH; post-translational modification; resins; trypsin;     Show all 12 Subjects
Abstract:
... BACKGROUND: Insulin controls hyperglycemia caused by diabetes, and virtually all treatments require exogenous insulin. However, the product’s extensive post-translational modifications have hindered the manufacture of recombinant insulin. RESULT: Here we report a novel production method for a monomeric B22Asp desB30 insulin analog (B22D desB30 insulin). Its precursor, DPIP, is fused to an N-termin ...
DOI:
10.1186/s12896-020-0598-3
PubMed:
31918694
PubMed Central:
PMC6953245

20. mRNA and microRNA selection for breast cancer molecular subtype stratification using meta-heuristic based algorithms

Author:
MotieGhader, Habib; Masoudi-Sobhanzadeh, Yosef; Ashtiani, Saman Hosseini; Masoudi-Nejad, Ali
Source:
Genomics 2020 v.112 no.5 pp. 3207-3217
ISSN:
0888-7543
Subject:
human diseases,   etc   ; algorithms; biomarkers; breast neoplasms; computational methodology; messenger RNA; microRNA; patients;     Show all 8 Subjects
Abstract:
... Cancer subtype stratification, which may help to make a better decision in treating cancerous patients, is one of the most crucial and challenging problems in cancer studies. To this end, various computational methods such as Feature selection, which enhances the accuracy of the classification and is an NP-Hard problem, have been proposed. However, the performance of the applied methods is still l ...
DOI:
10.1016/j.ygeno.2020.06.014