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You searched for: Subject "human diseases" Remove constraint Subject: "human diseases"
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1. Acid shock protein Asr induces protein aggregation to promote E. coli O157:H7 entering viable but non-culturable state under high pressure carbon dioxide stress

Author:
Hanxu Pan; Dong Yang; Yongtao Wang; Lei Rao; Xiaojun Liao
Source:
Food microbiology 2023 v.109 pp. 104136
ISSN:
0740-0020
Subject:
human diseases,   etc   ; Escherichia coli O157; acid tolerance; carbon dioxide; culture media; electron transport chain; food microbiology; food safety; food spoilage; public health; reverse transcriptase polymerase chain reaction; risk; transcriptomics;     Show all 13 Subjects
Abstract:
... Under stressful conditions, bacteria can enter viable but non-culturable (VBNC) state to survive. VBNC cells lost ability to grow on routine culture medium but are still alive and may revive in suitable conditions. The revived cells can consume nutrients or produce toxins, leading to food spoilage or human illness, posing great risk to food safety and public health. Previously, we have reported th ...
DOI:
10.1016/j.fm.2022.104136

2. Editorial for the Special Issue “Epidemiology of Enterovirus Disease”

Author:
Antonio Piralla; Elena Pariani
Source:
Microorganisms 2022 v.10 no.6 pp. -
ISSN:
2076-2607
Subject:
human diseases,   etc   ; Enterovirus; enterovirus Infections; epidemiology;     Show all 4 Subjects
Abstract:
... Enteroviruses (Enterovirus genus, Picornaviridae family) are distributed worldwide and are among the most common causes of human disease globally [...] ...
DOI:
10.3390/microorganisms10061221

3. The Mediator kinase module: an interface between cell signaling and transcription

Author:
Olivia Luyties; Dylan J. Taatjes
Source:
Trends in biochemical sciences 2022 v.47 no.4 pp. 314-327
ISSN:
0968-0004
Subject:
human diseases,   etc   ; DNA-directed RNA polymerase; chromatin;     Show all 3 Subjects
Abstract:
... The Mediator complex controls RNA polymerase II (pol II) activity by coordinating the assembly of pol II regulatory factors at transcription start sites and by mediating interactions between enhancer-bound transcription factors (TFs) and the pol II enzyme. Mediator structure and function is completely altered upon binding the Mediator kinase module, a multi-subunit complex that contains CDK8 or it ...
DOI:
10.1016/j.tibs.2022.01.002

4. A Slow Dynamic RNA Switch Regulates Processing of microRNA-21

Author:
Matthew D. Shortridge; Greg L. Olsen; Wen Yang; Matthew J. Walker; Gabriele Varani
Source:
Journal of molecular biology 2022 v.434 no.16 pp. 167694
ISSN:
0022-2836
Subject:
human diseases,   etc   ; ligands; microRNA; molecular biology; peptides;     Show all 5 Subjects
Abstract:
... The microRNAs are non-coding RNAs which post-transcriptionally regulate the expression of many eukaryotic genes, and whose dysregulation is a driver of human disease. Here we report the discovery of a very slow (0.1 s⁻¹) conformational rearrangement at the Dicer cleavage site of pre-miR-21, which regulates the relative concentration of readily- and inefficiently-processed RNA structural states. We ...
DOI:
10.1016/j.jmb.2022.167694

5. Metabolic analysis as a driver for discovery, diagnosis, and therapy

Author:
Ralph J. DeBerardinis; Kayvan R. Keshari
Source:
Cell 2022 v.185 no.15 pp. 2678-2689
ISSN:
0092-8674
Subject:
human diseases,   etc   ; genomics; metabolism; metabolomics; organelles; phenotype; therapeutics;     Show all 7 Subjects
Abstract:
... Metabolic anomalies contribute to tissue dysfunction. Current metabolism research spans from organelles to populations, and new technologies can accommodate investigation across these scales. Here, we review recent advancements in metabolic analysis, including small-scale metabolomics techniques amenable to organelles and rare cell types, functional screening to explore how cells respond to metabo ...
DOI:
10.1016/j.cell.2022.06.029

6. Molecular physiology of manganese in insects

Author:
Cecilia Pankau; Robin L Cooper
Source:
Current opinion in insect science 2022 v.51 pp. 100886
ISSN:
2214-5745
Subject:
human diseases,   etc   ; ecology; homeostasis; insects; manganese; organelles; toxicity;     Show all 7 Subjects
Abstract:
... Manganese is an essential element for maintaining life. Overexposure to the metal, however, can be toxic to organisms. Given the significant function of manganese in insects, agriculture, and human disease, as well as in the healthy ecology of the planet, the biological activities of manganese in insects needs consideration. Because of the role of manganese as a cofactor for essential enzymes pres ...
DOI:
10.1016/j.cois.2022.100886

7. Navigating the cellular landscape in tissue: Recent advances in defining the pathogenesis of human disease

Author:
Helen Y. Chen; Umaimainthan Palendira; Carl G. Feng
Source:
Computational and Structural Biotechnology Journal 2022 v.20 pp. 5256-5263
ISSN:
2001-0370
Subject:
human diseases,   etc   ; biomarkers; biotechnology; humans; landscapes; pathogenesis; therapeutics;     Show all 7 Subjects
Abstract:
... Over the past decade, our understanding of human diseases has rapidly grown from the rise of single-cell spatial biology. While conventional tissue imaging has focused on visualizing morphological features, the development of multiplex tissue imaging from fluorescence-based methods to DNA- and mass cytometry-based methods has allowed visualization of over 60 markers on a single tissue section. The ...
DOI:
10.1016/j.csbj.2022.09.005

8. Using Mice to Model Human Disease: Understanding the Roles of Baseline Housing-Induced and Experimentally Imposed Stresses in Animal Welfare and Experimental Reproducibility

Author:
Bonnie L. Hylander; Elizabeth A. Repasky; Sandra Sexton
Source:
Animals 2022 v.12 no.3 pp. -
ISSN:
2076-2615
Subject:
human diseases,   etc   ; animal welfare; biomarkers; experimental design; obesity;     Show all 5 Subjects
Abstract:
... Mice are the most common animal used to study disease, but there are real concerns about the reproducibility of many of these experiments. This review discusses how several different sources of chronic stress can directly impact experimental outcomes. Mandated housing conditions induce an underappreciated level of chronic stress but are not usually considered or reported as part of the experimenta ...
DOI:
10.3390/ani12030371

9. High-throughput techniques enable advances in the roles of DNA and RNA secondary structures in transcriptional and post-transcriptional gene regulation

Author:
Ilias Georgakopoulos-Soares; Candace S. Y. Chan; Nadav Ahituv; Martin Hemberg
Source:
Genome biology 2022 v.23 no.1 pp. 159
ISSN:
1474-760X
Subject:
human diseases,   etc   ; DNA; RNA; gene expression; genes; transcription (genetics);     Show all 6 Subjects
Abstract:
... The most stable structure of DNA is the canonical right-handed double helix termed B DNA. However, certain environments and sequence motifs favor alternative conformations, termed non-canonical secondary structures. The roles of DNA and RNA secondary structures in transcriptional regulation remain incompletely understood. However, advances in high-throughput assays have enabled genome wide charact ...
DOI:
10.1186/s13059-022-02727-6

10. Advances in Animal Models and Cutting-Edge Research in Alternatives: Proceedings of the Second International Conference on 3Rs Research and Progress, Hyderabad, 2021

Author:
Akshay Sonawane; Bharadwaja Vadloori; Suresh Poosala; Helena Kandarova; Mandar Kulkarni; Adedamola Olayanju; Tuli Dey; Uday Saxena; Lena Smirnova; Yasunari Kanda; Jaganmohan Reddy; Subhadra Dravida; Saikat Biswas; Mathieu Vinken; Montip Gettayacamin; Arti Ahluwalia; Franco Mondini; Somshuvra Bhattacharya; Pushkar Kulkarni; Kirsten Rosenmay Jacobsen; Subrahmanyam Vangala; Ana Luiza Millás
Source:
ATLA. Alternatives to laboratory animals v.50 no.2 pp. 156-171
ISSN:
0261-1929
Subject:
human diseases,   etc   ; animal use alternatives; biotechnology; laboratories; laboratory animals; India;     Show all 6 Subjects
Abstract:
... The fact that animal models fail to replicate human disease faithfully is now being widely accepted by researchers across the globe. As a result, they are exploring the use of alternatives to animal models. The time has come to refine our experimental practices, reduce the numbers and eventually replace the animals used in research with human-derived and human-relevant 3-D disease models. Oncoseek ...
DOI:
10.1177/02611929221089216

11. Modelling Human Brucellosis Based on Infection Rate and Vaccination Coverage of Sheep and Goats

Author:
Georgios Dougas; Aristomenis Katsiolis; Maria Linou; Polychronis Kostoulas; Charalambos Billinis
Source:
Pathogens 2022 v.11 no.2 pp. -
ISSN:
2076-0817
Subject:
human diseases,   etc   ; brucellosis; flocks; humans; models; sheep; vaccination; vaccines; Greece;     Show all 9 Subjects
Abstract:
... In this study, the vaccination coverage, serological sampling and infection rate of sheep and goats were evaluated as predictors for the modeling of human brucellosis in Greece. The human brucellosis disease frequency per local regional unit (RU) varied significantly (RR90) among consecutive years. The notification rate was higher (p < 0.001) in the RUs with implementation of vaccination in sheep ...
DOI:
10.3390/pathogens11020167

12. The next decade of protein structure

Author:
Corinne A. Lutomski; Tarick J. El-Baba; Carol V. Robinson; Roland Riek; Sjors H.W. Scheres; Nieng Yan; Mohammed AlQuraishi; Lu Gan
Source:
Cell 2022 v.185 no.15 pp. 2617-2620
ISSN:
0092-8674
Subject:
human diseases,   etc   ; cells; fields; human health; protein structure; proteins; wills;     Show all 7 Subjects
Abstract:
... With recent dramatic advances in various techniques used for protein structure research, we asked researchers to comment on the next exciting questions for the field and about how these techniques will advance our knowledge not only about proteins but also about human health and diseases. ...
DOI:
10.1016/j.cell.2022.06.011

13. Present and pioneer methods of early detection of food borne pathogens

Author:
G. Vidyadharani; H. K. Vijaya Bhavadharani; P. Sathishnath; Shruti Ramanathan; P. Sariga; A. Sandhya; S. Subikshaa; Shobana Sugumar
Source:
Journal of food science and technology 2022 v.59 no.6 pp. 2087-2107
ISSN:
0022-1155
Subject:
human diseases,   etc   ; biosensors; death; economic impact; food safety; nucleic acids;     Show all 6 Subjects
Abstract:
... Food-borne pathogens are a severe threat to human illness and death world-wide. Researchers have reported more than 250 food-borne diseases. Most of these are infections caused by a wide variety of bacteria, viruses, and parasites. It has a significant economic impact also. Detection of pathogenic microbes is thus essential for food safety. Such identification techniques could meet the following p ...
DOI:
10.1007/s13197-021-05130-4

14. Structural Insights into Alphavirus Assembly Revealed by the Cryo-EM Structure of Getah Virus

Author:
Ming Wang; Zhenzhao Sun; Chenxi Cui; Shida Wang; Decheng Yang; Zhibin Shi; Xinyu Wei; Pengfei Wang; Weiyao Sun; Jing Zhu; Jiaqi Li; Bingchen Du; Zaisi Liu; Lili Wei; Chunguo Liu; Xijun He; Xiangxi Wang; Xinzheng Zhang; Jingfei Wang
Source:
Viruses 2022 v.14 no.2 pp. -
ISSN:
1999-4915
Subject:
human diseases,   etc   ; Getah virus; cattle; glycoproteins; membrane fusion; pathogenicity; viruses;     Show all 7 Subjects
Abstract:
... Getah virus (GETV) is a member of the alphavirus genus, and it infects a variety of animal species, including horses, pigs, cattle, and foxes. Human infection with this virus has also been reported. The structure of GETV has not yet been determined. In this study, we report the cryo-EM structure of GETV at a resolution of 3.5 Å. This structure reveals conformational polymorphism of the envelope gl ...
DOI:
10.3390/v14020327

15. A cross-disorder dosage sensitivity map of the human genome

Author:
Ryan L. Collins; Joseph T. Glessner; Eleonora Porcu; Maarja Lepamets; Rhonda Brandon; Christopher Lauricella; Lide Han; Theodore Morley; Lisa-Marie Niestroj; Jacob Ulirsch; Selin Everett; Daniel P. Howrigan; Philip M. Boone; Jack Fu; Konrad J. Karczewski; Georgios Kellaris; Chelsea Lowther; Diane Lucente; Kiana Mohajeri; Margit Nõukas; Xander Nuttle; Kaitlin E. Samocha; Mi Trinh; Farid Ullah; Urmo Võsa; Matthew E. Hurles; Swaroop Aradhya; Erica E. Davis; Hilary Finucane; James F. Gusella; Aura Janze; Nicholas Katsanis; Ludmila Matyakhina; Benjamin M. Neale; David Sanders; Stephanie Warren; Jennelle C. Hodge; Dennis Lal; Douglas M. Ruderfer; Jeanne Meck; Reedik Mägi; Tõnu Esko; Alexandre Reymond; Zoltán Kutalik; Hakon Hakonarson; Shamil Sunyaev; Harrison Brand; Michael E. Talkowski; Andres Metspalu; Mari Nelis; Lili Milani; Epi25 Consortium; Estonian Biobank Research Team
Source:
Cell 2022 v.185 no.16 pp. 3041-3055.e25
ISSN:
0092-8674
Subject:
human diseases,   etc   ; artificial intelligence; genes; haploinsufficiency; human population; humans; risk;     Show all 7 Subjects
Abstract:
... Rare copy-number variants (rCNVs) include deletions and duplications that occur infrequently in the global human population and can confer substantial risk for disease. In this study, we aimed to quantify the properties of haploinsufficiency (i.e., deletion intolerance) and triplosensitivity (i.e., duplication intolerance) throughout the human genome. We harmonized and meta-analyzed rCNVs from nea ...
DOI:
10.1016/j.cell.2022.06.036

16. Antioxidant and Anti-Inflammatory Agents from the Sea: A Molecular Treasure for New Potential Drugs

Author:
Marzia Vasarri; Donatella Degl’Innocenti
Source:
Marine drugs 2022 v.20 no.2 pp. -
ISSN:
1660-3397
Subject:
human diseases,   etc   ; anti-inflammatory agents; antioxidants; human health; new drugs; therapeutics;     Show all 6 Subjects
Abstract:
... Nowadays, natural compounds are widely used worldwide for the treatment of human diseases and health disorders [...] ...
DOI:
10.3390/md20020132

17. Whole-slide imaging and a Fiji-based image analysis workflow of immunohistochemistry staining of pancreatic islets

Author:
Emma Jane Buckels; Jacqueline Mary Ross; Hui Hui Phua; Frank Harry Bloomfield; Anne Louise Jaquiery
Source:
MethodsX 2022 v.9 pp. 101856
ISSN:
2215-0161
Subject:
human diseases,   etc   ; automation; computer software; diabetes; image analysis; immunohistochemistry; microscopy; Fiji;     Show all 8 Subjects
Abstract:
... Quantification of cell populations in tissue sections is frequently examined in studies of human disease. However, traditional manual imaging of sections stained with immunohistochemistry is laborious, time-consuming, and often assesses fields of view rather than the whole tissue section. The analysis is usually manual or utilises expensive proprietary image analysis platforms. Whole-slide imaging ...
DOI:
10.1016/j.mex.2022.101856

18. Merging Established Mechanisms with New Insights: Condensates, Hubs, and the Regulation of RNA Polymerase II Transcription

Author:
Megan Palacio; Dylan J. Taatjes
Source:
Journal of molecular biology 2022 v.434 no.1 pp. 167216
ISSN:
0022-2836
Subject:
human diseases,   etc   ; DNA-directed RNA polymerase; RNA; metabolites; molecular biology; separation;     Show all 6 Subjects
Abstract:
... The regulation of RNA polymerase II (pol II) transcription requires a complex and context-specific array of proteins and protein complexes, as well as nucleic acids and metabolites. Every major physiological process requires coordinated transcription of specific sets of genes at the appropriate time, and a breakdown in this regulation is a hallmark of human disease. A proliferation of recent studi ...
DOI:
10.1016/j.jmb.2021.167216

19. Current Progress and Prospects in Rabbit Cloning

Author:
Wenbin Cao; Jinpeng Zhao; Pengxiang Qu; Enqi Liu
Source:
Cellular reprogramming 2022 v.24 no.2 pp. 63-70
ISSN:
2152-4998
Subject:
human diseases,   etc   ; biomedical research; bioreactors; genes; rabbits; somatic cells; stem cells; therapeutics;     Show all 8 Subjects
Abstract:
... Somatic cell nuclear transfer (SCNT) shows great value in the generation of transgenic animals, protection of endangered animals, and stem cell therapy. The combination of SCNT and gene editing has produced a variety of genetically modified animals for life science and medical research. Rabbits have unique advantages as transgenic bioreactors and human disease models; however, the low SCNT efficie ...
DOI:
10.1089/cell.2021.0090

20. Disease‐specific interactome alterations via epichaperomics: the case for Alzheimer’s disease

Author:
Stephen D. Ginsberg; Thomas A. Neubert; Sahil Sharma; Chander S. Digwal; Pengrong Yan; Calin Timbus; Tai Wang; Gabriela Chiosis
Source:
FEBS journal 2022 v.289 no.8 pp. 2047-2066
ISSN:
1742-464X
Subject:
human diseases,   etc   ; disease diagnosis; epigenetics; humans; phenotype; precision medicine; protein-protein interactions;     Show all 7 Subjects
Abstract:
... The increasingly appreciated prevalence of complicated stressor‐to‐phenotype associations in human disease requires a greater understanding of how specific stressors affect systems or interactome properties. Many currently untreatable diseases arise due to variations in, and through a combination of, multiple stressors of genetic, epigenetic, and environmental nature. Unfortunately, how such stres ...
DOI:
10.1111/febs.16031