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You searched for: Subject "humoral immunity" Remove constraint Subject: "humoral immunity"
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1. Genetic diversity, population structure, linkage disequilibrium and GWAS for resistance to WSSV in Pacific white shrimp (Litopenaeus vannamei) using a 50K SNP chip

Author:
Thania Medrano-Mendoza; Baltasar F. García; Alejandra Caballero-Zamora; José M. Yáñez; Leobardo Montoya-Rodríguez; Juan C. Quintana-Casares; Marina Durán-Aguilar; Gabriel R. Campos-Montes
Source:
Aquaculture 2023 v.562 pp. 738835
ISSN:
0044-8486
Subject:
humoral immunity,   etc   ; DNA-directed RNA polymerase; Litopenaeus vannamei; White spot syndrome virus; aquaculture; arylsulfatase; chromosomes; death; genetic variance; genetic variation; genome-wide association study; genotyping; hepatopancreas; immune response; linkage disequilibrium; marker-assisted selection; necrotizing hepatopancreatitis; oxidoreductases; population structure; principal component analysis; quality control; Ecuador; Panama;     Show all 23 Subjects
Abstract:
... The objectives of this research were to assess the genetic diversity, population structure, linkage disequilibrium and perform a genome-wide association study (GWAS) to search for single nucleotide polymorphisms (SNPs) that associate with the resistance of Pacific white shrimp (Litopenaeus vannamei) to White Spot Syndrome Virus (WSSV). The line here analyzed was formerly founded with animals origi ...
DOI:
10.1016/j.aquaculture.2022.738835

2. Antibody interfaces revealed through structural mining

Author:
Yizhou Yin; Matthew G. Romei; Kannan Sankar; Lipika R. Pal; Kam Hon Hoi; Yanli Yang; Brandon Leonard; Gladys De Leon Boenig; Nikit Kumar; Marissa Matsumoto; Jian Payandeh; Seth F. Harris; John Moult; Greg A. Lazar
Source:
Computational and Structural Biotechnology Journal 2022 v.20 pp. 4952-4968
ISSN:
2001-0370
Subject:
humoral immunity,   etc   ; antibodies; biotechnology; disulfides; therapeutics;     Show all 5 Subjects
Abstract:
... Antibodies are fundamental effectors of humoral immunity, and have become a highly successful class of therapeutics. There is increasing evidence that antibodies utilize transient homotypic interactions to enhance function, and elucidation of such interactions can provide insights into their biology and new opportunities for their optimization as drugs. Yet the transitory nature of weak interactio ...
DOI:
10.1016/j.csbj.2022.08.048

3. Nfkbid-mediated humoral immunity during secondary toxoplasmosis

Author:
Imtiaz A. Khan; Magali Moretto
Source:
Trends in parasitology 2022 v.38 no.4 pp. 272-273
ISSN:
1471-4922
Subject:
humoral immunity,   etc   ; B-lymphocytes; Toxoplasma gondii; genetics; parasitology; toxoplasmosis;     Show all 6 Subjects
Abstract:
... Vaccine-mediated immunity to parasites has not been achieved. Immune C57BL/6 mice are susceptible to secondary Toxoplasma gondii infection. Using a forward genetics approach, Souza et al. identify Nfkbid as an important factor for the regulation of B cell immunity during secondary Toxoplasma infection and protection against rechallenge. ...
DOI:
10.1016/j.pt.2022.01.010

4. Breakthrough Infections: A Challenge towards Measles Elimination?

Author:
Clara Fappani; Maria Gori; Marta Canuti; Mara Terraneo; Daniela Colzani; Elisabetta Tanzi; Antonella Amendola; Silvia Bianchi
Source:
Microorganisms 2022 v.10 no.8 pp. -
ISSN:
2076-2607
Subject:
humoral immunity,   etc   ; antibodies; decline; live vaccines; measles; risk; vaccination; virus transmission;     Show all 8 Subjects
Abstract:
... Measles is one of the most contagious diseases known to man. Despite the existence of a safe and effective live attenuated vaccine, measles can appear in vaccinated individuals. Paradoxically, breakthrough cases increase as vaccination coverage in the general population rises. In measles endemic areas, breakthrough cases represent less than 10% of total infections, while in areas with high vaccina ...
DOI:
10.3390/microorganisms10081567

5. Engineering immunity via skin-directed drug delivery devices

Author:
Suryanarayana Polaka; Vaishali Makwana; Nupur Vasdev; Anjani Sheth; Kuldeep Rajpoot; Pinaki Sengupta; Rakesh Kumar Tekade
Source:
Journal of controlled release 2022 v.345 pp. 385-404
ISSN:
0168-3659
Subject:
humoral immunity,   etc   ; dendrimers; immunization; markets; niosomes; production costs; vaccine adjuvants; vaccines;     Show all 8 Subjects
Abstract:
... Extensive research is underway to discover a safe and effective vehicle to deliver the vaccines at the desired cutaneous site. These efforts majorly comprise the development of a fit-to-purpose vehicle for in-situ intracutaneous vaccine delivery for achieving the systemic cellular and humoral response to combat infectious diseases. Advancements in nanoscience, bioengineering, and skin science prov ...
DOI:
10.1016/j.jconrel.2022.03.013

6. Long lasting immunity in trichinellosis – insight from a small study group

Author:
N. Ilic; S. Vasilev; A. Gruden-Movsesijan; M. Gnjatovic; Lj. Sofronic-Milosavljevic; I. Mitic
Source:
Journal of helminthology 2022 v.96 pp. e35
ISSN:
1475-2697
Subject:
humoral immunity,   etc   ; Trichinella spiralis; chronic diseases; pain; parasites; trichinosis; villages; Serbia;     Show all 8 Subjects
Abstract:
... Trichinellosis in humans is most often caused by the parasite Trichinella spiralis. The clinical course of the disease is diverse and the symptoms can vary from mild to severe. Symptoms usually disappear within a few months, but encysted larvae in the muscles can cause myalgia and weakness that last for years. However, the existence of chronic trichinellosis as a disease is still debatable. This s ...
DOI:
10.1017/S0022149X22000268

7. Transcutaneous immunization via dissolving microneedles protects mice from lethal influenza H7N9 virus challenge

Author:
Siqi Liu; Guozhong Yang; Minghui Li; Fang Sun; Yufeng Li; Xiliang Wang; Yunhua Gao; Penghui Yang
Source:
Vaccine 2022 pp. -
ISSN:
0264-410X
Subject:
humoral immunity,   etc   ; antigens; avian influenza; immunization; mice; models; mortality; vaccines; viruses; China;     Show all 10 Subjects
Abstract:
... Avian influenza H7N9 virus has first emerged in 2013 and since then has spread in China in five seasonal waves. In humans, influenza H7N9 virus infection is associated with a high fatality rate; thus, an effective vaccine for this virus is needed. In the present study, we evaluated the usefulness of dissolving microneedles (MNs) loaded with influenza H7N9 vaccine in terms of the dissolution time, ...
DOI:
10.1016/j.vaccine.2022.09.008

8. Genotype VII.1.1-Based Newcastle Disease Virus Vaccines Afford Better Protection against Field Isolates in Commercial Broiler Chickens

Author:
Abdelmonem A. A. Dewidar; Walid H. Kilany; Azza A. El-Sawah; Salama A. S. Shany; Al-Hussien M. Dahshan; Islam Hisham; Magdy F. Elkady; Ahmed Ali
Source:
Animals 2022 v.12 no.13 pp. -
ISSN:
2076-2615
Subject:
humoral immunity,   etc   ; Avian orthoavulavirus 1; Newcastle disease; eyes; genotype; vaccination; virulence; viruses;     Show all 8 Subjects
Abstract:
... This study evaluated the efficacy of live and inactivated conventional GII LaSota and recombinant GVII Newcastle disease vaccines in commercial broilers. The experimental groups (G2–G7) were vaccinated on day 7 and day 21 of age with live vaccines from the same vaccine type “GII LaSota, GVII vaccine (A), GVII vaccine (B)” via eye drop; however, G3, G5, and G7 received a single dose from inactivate ...
DOI:
10.3390/ani12131696

9. Getting to the (germinal) center of humoral immune responses to SARS-CoV-2

Author:
Stuart G. Tangye; Deborah L. Burnett; Rowena A. Bull
Source:
Cell 2022 v.185 no.6 pp. 945-948
ISSN:
0092-8674
Subject:
humoral immunity,   etc   ; Severe acute respiratory syndrome coronavirus 2; cells; lymph nodes; vaccination;     Show all 5 Subjects
Abstract:
... Long-term protection against SARS-CoV-2 requires effective and durable immunity. In this issue of Cell, two papers closely examine germinal centers, the physiological birthplace of adaptive immunity, to quantify the specificity, breadth, magnitude, and persistence of systemic and local humoral immune responses following natural infection with, or vaccination against, SARS-CoV-2. ...
DOI:
10.1016/j.cell.2022.02.018

10. CD40 signaling-mediated delay in terminal differentiation of B cells enables alternate fate choices during early divisions

Author:
Devi Prasad Vijayashankar; Tushar Vaidya
Source:
Molecular immunology 2022 v.144 pp. 1-15
ISSN:
0161-5890
Subject:
humoral immunity,   etc   ; cell differentiation; disease control; lipopolysaccharides; lymph nodes; memory; vaccine development;     Show all 7 Subjects
Abstract:
... Memory B cells and differentiated plasma cells combine to confer sustained humoral immunity. Nonetheless, we are yet to understand how B cells decide between these fates. Although pan-T cell help augments plasma cell differentiation, signaling via CD40 alone is considered to be inhibitory. Here, we examine the capacity of CD40 signaling to interfere with lipopolysaccharide-induced differentiation. ...
DOI:
10.1016/j.molimm.2022.01.012

11. Differential antibody responses in sows and finishing pigs naturally infected with African swine fever virus under field conditions

Author:
Hung Q. Luong; Huong TL. Lai; Luc D. Do; Bo X. Ha; Giap V. Nguyen; Hiep LX. Vu
Source:
Virus research 2022 v.307 pp. 198621
ISSN:
0168-1702
Subject:
humoral immunity,   etc   ; African swine fever virus; antibodies; blood serum; lectins; research; virulence; viruses;     Show all 8 Subjects
Abstract:
... Antibody profile of pigs naturally infected with a virulent African swine fever virus (ASFV) strain under field conditions was studied. Twenty-three serum samples were collected from pigs surviving a natural ASFV infection: 17 samples from finishing pigs (∼7 months old) and 6 samples from sows (between 12 and 36 months old). Additionally, 24 serum samples were collected from ASFV-naïve pigs to ser ...
DOI:
10.1016/j.virusres.2021.198621

12. Review of use of inactivated poliovirus vaccine in campaigns to control type 2 circulating vaccine derived poliovirus (cVDPV) outbreaks

Author:
Concepcion F. Estivariz; Stephanie D. Kovacs; Ondrej Mach
Source:
Vaccine 2022 pp. -
ISSN:
0264-410X
Subject:
humoral immunity,   etc   ; Enterovirus C; immunization; intestines; mucosal immunity; risk; risk reduction; serotypes; vaccines;     Show all 9 Subjects
Abstract:
... Delivering inactivated poliovirus vaccine (IPV) with oral poliovirus vaccine (OPV) in campaigns has been explored to accelerate the control of type 2 circulating vaccine-derived poliovirus (cVDPV) outbreaks. A review of scientific literature suggests that among populations with high prevalence of OPV failure, a booster with IPV after at least two doses of OPV may close remaining humoral and mucosa ...
DOI:
10.1016/j.vaccine.2022.03.027

13. Assessment of humoral immune response to two mRNA SARS‐CoV‐2 vaccines (Moderna and Pfizer) in healthcare workers fully vaccinated with and without a history of previous infection

Author:
Laura Serrano; Sonia Algarate; Beatriz Herrero‐Cortina; Jessica Bueno; María T. González‐Barriga; María Ducons; Jesica Montero‐Marco; Beatriz Acha; Ana Taboada; Pilar Sanz‐Burillo; Cristina Yuste; Rafael Benito; RIPOVAC Study Group
Source:
Journal of applied microbiology 2022 v.133 no.3 pp. 1969-1974
ISSN:
1364-5072
Subject:
humoral immunity,   etc   ; Severe acute respiratory syndrome coronavirus 2; antibodies; health services; microbiology; vaccination; Spain;     Show all 7 Subjects
Abstract:
... AIMS: Presence of anti‐S1 region of SARS‐CoV‐2 spike protein was analysed, at two and eight months, in 477 immunocompetent healthcare workers in Zaragoza, Spain, vaccinated with mRNA‐1273 (Moderna) or BNT162b2 (Pfizer). METHODS AND RESULTS: Antibody analysis was performed with Alinity i System (Abbott). At 2 months, 100% of vaccinated had anti‐S1 IgG (mean = 13,285 AU ml⁻¹). This value was signifi ...
DOI:
10.1111/jam.15699

14. The effect of the E484K mutation of SARS-CoV-2 on the neutralizing activity of antibodies from BNT162b2 vaccinated individuals

Author:
Yoshifumi Uwamino; Takashi Yokoyama; Takako Shimura; Tomoyasu Nishimura; Yasunori Sato; Masatoshi Wakui; Kenjiro Kosaki; Naoki Hasegawa; Mitsuru Murata
Source:
Vaccine 2022 v.40 no.13 pp. 1928-1931
ISSN:
0264-410X
Subject:
humoral immunity,   etc   ; Severe acute respiratory syndrome coronavirus 2; antibodies; blood serum; mutation; neutralization; vaccines;     Show all 7 Subjects
Abstract:
... The reduced vaccine efficacy against the SARS-CoV-2 variant lineage B. 1.351 (beta variant) containing the E484K and N501Y mutations is well known. The E484K mutation in SARS-CoV-2 is thought to be responsible for weakened humoral immunity. Vaccine efficacy against the R.1 lineage, which contains the E484K mutation but not the N501Y mutation, is uncertain. Serum samples were collected from 100 hea ...
DOI:
10.1016/j.vaccine.2022.02.047

15. Partial in vivo protection against Peruvian spider Loxosceles laeta venom by immunization with a multiepitopic protein (rMEPLox)

Author:
Ruth L. Quispe; Michael L. Jaramillo; Frank Torres-Huaco; Cesar Bonilla; Jacqueline Isasi; Clara Guerra-Duarte; Carlos Chávez-Olórtegui
Source:
Toxicon 2022 v.215 pp. 1-5
ISSN:
0041-0101
Subject:
humoral immunity,   etc   ; Loxosceles; antivenoms; epitopes; hyaluronoglucosaminidase; metalloproteinases; mice; public health; spiders; vaccination; venoms; Peru;     Show all 12 Subjects
Abstract:
... Loxoscelism is a serious public health problem in Peru, with approximately 2500 accidents reported per year. To envision alternatives to cope with this health problem, the neutralizing humoral immune response against the lethal effects of Peruvian spider Loxosceles laeta venom was evaluated in a mouse model by immunization with a non-toxic multiepitopic protein (rMEPLox). This immunogen contains e ...
DOI:
10.1016/j.toxicon.2022.05.044

16. Robust humoral immune response against rabies virus in rabbits and guinea pigs immunized with plasmid DNA vectors encoding rabies virus glycoproteins – An approach to the production of polyclonal antibody reagents

Author:
Dmitriy V. Volokhov; Vyacheslav Furtak; Cynthia Allen; Gayle Pulle; Michelle D. Zajac; Yotam Levin; Efrat Kochba; Susan M. Moore
Source:
Molecular and cellular probes 2022 v.64 pp. 101833
ISSN:
0890-8508
Subject:
humoral immunity,   etc   ; Rabies lyssavirus; fluorescence; glycoproteins; immunization; plasmids; polyclonal antibodies; rabbits; rabies; viruses; Guinea;     Show all 11 Subjects
Abstract:
... DNA-based immunization has been previously shown to be an efficient approach to induce robust immunity against infectious diseases in animals and humans. The advantages of DNA vaccines are simplicity of their construction and production, low cost, high stability, and ability to elicit a full spectrum of immune responses to target antigens. The goals of this study were (i) to assess the antibody im ...
DOI:
10.1016/j.mcp.2022.101833

17. Extensive involvement of CD40 and CD154 costimulators in multiple T cell-mediated responses in a perciform fish Larimichthys crocea

Author:
Ning Su; Chun-yu Jin; Chong-bin Hu; Tong Shao; Jian-fei Ji; Lu-lu Qin; Dong-Dong Fan; Ai-fu Lin; Li-xin Xiang; Jian-zhong Shao
Source:
Developmental and comparative immunology 2022 v.134 pp. 104460
ISSN:
0145-305X
Subject:
humoral immunity,   etc   ; Aeromonas hydrophila; Larimichthys crocea; antibodies; antigens; evolution; fish; fluorescent antibody technique; transcription (genetics);     Show all 9 Subjects
Abstract:
... CD40 and CD154 are well-characterized costimulatory molecules involved in adaptive humoral immunity in humans and other mammals. These two costimulatory molecules were found to be originated from teleost fish during vertebrate evolution. However, the functionality of fish CD40 and CD154 remains to be explored. In this study, we identified the CD40 and CD154 homologs (LcCD40 and LcCD154) from large ...
DOI:
10.1016/j.dci.2022.104460

18. Dynamics of HIV-1/HTLV-I Co-Infection Model with Humoral Immunity and Cellular Infection

Author:
Noura H. AlShamrani; Matuka A. Alshaikh; Ahmed M. Elaiw; Khalid Hattaf
Source:
Viruses 2022 v.14 no.8 pp. -
ISSN:
1999-4915
Subject:
humoral immunity,   etc   ; HIV infections; Human immunodeficiency virus 1; biomedical research; immune system; mixed infection; models;     Show all 7 Subjects
Abstract:
... Human immunodeficiency virus type 1 (HIV-1) and human T-lymphotropic virus type I (HTLV-I) are two retroviruses which infect the same target, CD4+ T cells. This type of cell is considered the main component of the immune system. Since both viruses have the same means of transmission between individuals, HIV-1-infected patients are more exposed to the chance of co-infection with HTLV-I, and vice ve ...
DOI:
10.3390/v14081719

19. Onset of the humoral immune response of layer chicks vaccinated in ovo with strain F Mycoplasma gallisepticum vaccine and evidence of male-biased mortality

Author:
K.E.C. Elliott; S.L. Branton; J.D. Evans; C.L. Magee; E.D. Peebles
Source:
Poultry science 2022 v.101 no.4 pp. 101761
ISSN:
0032-5791
Subject:
humoral immunity,   etc   ; Mycoplasma gallisepticum; antibodies; antibody detection; antibody formation; blood; blood sampling; males; mortality; vaccination; vaccines;     Show all 11 Subjects
Abstract:
... Previous trials in which layers were in ovo-vaccinated against strain F Mycoplasma gallisepticum (FMG) showed that nearly 50% of the birds produced IgM antibody against FMG at 6 wk of age (WOA). Standard FMG vaccination application at 9 or 10 woa, result in this percentage at approximately 15 woa. This study investigated when FMG in ovo-vaccinated birds initiate a humoral immune response prior to ...
DOI:
10.1016/j.psj.2022.101761
CHORUS:
10.1016/j.psj.2022.101761

20. Recent advancements in nanoparticle-mediated approaches for restoration of multiple sclerosis

Author:
Niloufar Rahiman; Marzieh Mohammadi; Seyedeh Hoda Alavizadeh; Leila Arabi; Ali Badiee; Mahmoud Reza Jaafari
Source:
Journal of controlled release 2022 v.343 pp. 620-644
ISSN:
0168-3659
Subject:
humoral immunity,   etc   ; autoimmune diseases; cell-mediated immunity; cytokines; disease control; immunopathology; laboratory animals; prognosis; sclerosis; therapeutics;     Show all 10 Subjects
Abstract:
... Multiple Sclerosis (MS) is an autoimmune disease with complicated immunopathology which necessitates considering multifactorial aspects for its management. Nano-sized pharmaceutical carriers named nanoparticles (NPs) can support impressive management of disease not only in early detection and prognosis level but also in a therapeutic manner. The most prominent initiator of MS is the domination of ...
DOI:
10.1016/j.jconrel.2022.02.009